metricas
covid
Buscar en
Clínica e Investigación en Arteriosclerosis (English Edition)
Toda la web
Inicio Clínica e Investigación en Arteriosclerosis (English Edition) Morbid obesity and dyslipidaemia: The impact of bariatric surgery
Journal Information

Statistics

Follow this link to access the full text of the article

Review article
Morbid obesity and dyslipidaemia: The impact of bariatric surgery
Obesidad mórbida y dislipemia: impacto de la cirugía bariátrica
Elisenda Climenta,b, David Benaigesa,b,c, Albert Godaya,b,c, Montserrat Villatoroa, Helena Juliàa, José M. Ramónc,d, Juana A. Floresa,b,c, Juan Pedro-Boteta,b,c,
Corresponding author
86620@parcdesalutmar.cat

Corresponding author.
a Servicio de Endocrinología y Nutrición, Hospital del Mar, Barcelona, Spain
b Departamento de Medicina, Universitat Autònoma de Barcelona, Campus Universitari Mar, Barcelona, Spain
c Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Barcelona, Spain
d Servicio de Cirugía General, Hospital del Mar, Barcelona, Spain
Read
1325
Times
was read the article
197
Total PDF
1128
Total HTML
Share statistics
 array:22 [
  "pii" => "S2529912320300188"
  "issn" => "25299123"
  "doi" => "10.1016/j.artere.2019.11.007"
  "estado" => "S300"
  "fechaPublicacion" => "2020-03-01"
  "aid" => "513"
  "copyrightAnyo" => "2020"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "rev"
  "cita" => "Clin Investig Arterioscler. 2020;32:79-86"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0214916819301421"
      "issn" => "02149168"
      "doi" => "10.1016/j.arteri.2019.11.001"
      "estado" => "S300"
      "fechaPublicacion" => "2020-03-01"
      "aid" => "513"
      "copyright" => "Sociedad Española de Arteriosclerosis"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "rev"
      "cita" => "Clin Invest Arterioscl. 2020;32:79-86"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Revisi&#243;n</span>"
        "titulo" => "Obesidad m&#243;rbida y dislipemia&#58; impacto de la cirug&#237;a bari&#225;trica"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "79"
            "paginaFinal" => "86"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Morbid obesity and dyslipidaemia&#58; The impact of bariatric surgery"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1625
                "Ancho" => 2167
                "Tamanyo" => 187805
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Tipos de t&#233;cnicas de cirug&#237;a bari&#225;trica&#46; Adaptado de Pories WJ&#46; Bariatric surgery&#58; Risks and rewards&#46; J Clin Endocrinol Metab&#46; 2008&#59;93&#58;S89-96&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Elisenda Climent, David Benaiges, Albert Goday, Montserrat Villatoro, Helena Juli&#224;, Jose M&#46; Ram&#243;n, Juana A&#46; Flores, Juan Pedro-Botet"
            "autores" => array:8 [
              0 => array:2 [
                "nombre" => "Elisenda"
                "apellidos" => "Climent"
              ]
              1 => array:2 [
                "nombre" => "David"
                "apellidos" => "Benaiges"
              ]
              2 => array:2 [
                "nombre" => "Albert"
                "apellidos" => "Goday"
              ]
              3 => array:2 [
                "nombre" => "Montserrat"
                "apellidos" => "Villatoro"
              ]
              4 => array:2 [
                "nombre" => "Helena"
                "apellidos" => "Juli&#224;"
              ]
              5 => array:2 [
                "nombre" => "Jose M&#46;"
                "apellidos" => "Ram&#243;n"
              ]
              6 => array:2 [
                "nombre" => "Juana A&#46;"
                "apellidos" => "Flores"
              ]
              7 => array:2 [
                "nombre" => "Juan"
                "apellidos" => "Pedro-Botet"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2529912320300188"
          "doi" => "10.1016/j.artere.2019.11.007"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529912320300188?idApp=UINPBA00004N"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0214916819301421?idApp=UINPBA00004N"
      "url" => "/02149168/0000003200000002/v1_202003120633/S0214916819301421/v1_202003120633/es/main.assets"
    ]
  ]
  "itemAnterior" => array:17 [
    "pii" => "S2529912320300206"
    "issn" => "25299123"
    "doi" => "10.1016/j.artere.2020.03.002"
    "estado" => "S300"
    "fechaPublicacion" => "2020-03-01"
    "aid" => "502"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "rev"
    "cita" => "Clin Investig Arterioscler. 2020;32:70-8"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Review article</span>"
      "titulo" => "Alterations on a key nephrogenic&#47;cardiogenic gene expression linked to hypertension development"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "70"
          "paginaFinal" => "78"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Alteraciones en la expresi&#243;n de un gen clave en el desarrollo renal y card&#237;aco vinculada con el desarrollo de la hipertensi&#243;n arterial"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1846
              "Ancho" => 2167
              "Tamanyo" => 279578
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Graphical overview&#46; &#40;A&#41; Small increases in ON levels produce an increase in the expressions of Hsp70&#44; WT-1&#44; and VDR&#46; &#40;B&#41; In turn&#44; WT-1&#44; as a transcription factor&#44; regulates the expression of the principal isoform of the NO synthase&#44; producing a positive feedback&#46; &#40;C&#41; Also&#44; WT-1 positively regulates Hsp70 and VDR&#46; &#40;D&#41; WT-1 stabilizes Bcl-2 and the mitochondrial membrane&#44; preventing the release of cytochrome C&#46; In this way&#44; cell death is avoided&#46; &#40;E&#41; Renal remodeling&#44; oxidative stress&#44; the activation of the RAAS and the decrease of vitamin D&#44; produce the release of ROS&#44; which increases the risk of hypertension&#46; &#40;F&#41; VDR and WT-1 inhibit renin&#44; thus inhibiting the RAAS system&#44; and hypertension&#46; &#40;G&#41; WT-1 is not only crucial for kidney development but also to prevent kidney damage and high blood pressure&#46; The continuous arrows indicate positive regulation&#44; while the discontinuous lines indicate inhibition&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Luciana Mazzei, Ra&#250;l Sanz, Walter Manucha"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Luciana"
              "apellidos" => "Mazzei"
            ]
            1 => array:2 [
              "nombre" => "Ra&#250;l"
              "apellidos" => "Sanz"
            ]
            2 => array:2 [
              "nombre" => "Walter"
              "apellidos" => "Manucha"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529912320300206?idApp=UINPBA00004N"
    "url" => "/25299123/0000003200000002/v1_202003210823/S2529912320300206/v1_202003210823/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Review article</span>"
    "titulo" => "Morbid obesity and dyslipidaemia&#58; The impact of bariatric surgery"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "79"
        "paginaFinal" => "86"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Elisenda Climent, David Benaiges, Albert Goday, Montserrat Villatoro, Helena Juli&#224;, Jos&#233; M&#46; Ram&#243;n, Juana A&#46; Flores, Juan Pedro-Botet"
        "autores" => array:8 [
          0 => array:3 [
            "nombre" => "Elisenda"
            "apellidos" => "Climent"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "David"
            "apellidos" => "Benaiges"
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Albert"
            "apellidos" => "Goday"
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Montserrat"
            "apellidos" => "Villatoro"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Helena"
            "apellidos" => "Juli&#224;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Jos&#233; M&#46;"
            "apellidos" => "Ram&#243;n"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Juana A&#46;"
            "apellidos" => "Flores"
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          7 => array:4 [
            "nombre" => "Juan"
            "apellidos" => "Pedro-Botet"
            "email" => array:1 [
              0 => "86620@parcdesalutmar.cat"
            ]
            "referencia" => array:4 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              3 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Servicio de Endocrinolog&#237;a y Nutrici&#243;n&#44; Hospital del Mar&#44; Barcelona&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Departamento de Medicina&#44; Universitat Aut&#242;noma de Barcelona&#44; Campus Universitari Mar&#44; Barcelona&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Institut Hospital del Mar d&#8217;Investigacions M&#232;diques &#40;IMIM&#41;&#44; Barcelona&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Servicio de Cirug&#237;a General&#44; Hospital del Mar&#44; Barcelona&#44; Spain"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Obesidad m&#243;rbida y dislipemia&#58; impacto de la cirug&#237;a bari&#225;trica"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1625
            "Ancho" => 2167
            "Tamanyo" => 184874
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Types of bariatric surgical techniques&#46; Adapted from Pories WJ&#46; Bariatric surgery&#58; Risks and rewards&#46; J Clin Endocrinol Metab&#46; 2008&#59;93&#58;S89-96&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Definition and epidemiology of obesity</span><p id="par0005" class="elsevierStylePara elsevierViewall">Obesity is a chronic metabolic disease with a multifactorial origin&#46; It is defined as excess weight due to the accumulation of body fat&#46; It is classified according to the body mass index &#40;BMI&#41; of each individual&#44; and severe obesity is considered to exist when the BMI is above 40&#8239;kg&#47;m<span class="elsevierStyleSup">2</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">It has become exponentially more prevalent in recent years&#44; and it is now a public health problem of the first order&#46; It is estimated that up to 1&#46;6 billion people in the world are overweight and 400 million are obese&#44; with the resulting increase in cardiovascular morbimortality&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Two recent cross-sectional studies in Spain have reflected similar rates of obesity&#46; Thus the ENRICA<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> study in a population above 18 years old found a prevalence of obesity close to 23&#37;&#44; and the ENPE<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> study of a non-institutionalised population aged from 25 to 64 years old found a frequency of obesity of approximately 22&#37;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Obesity often has associated comorbidities&#44; such as type 2 diabetes mellitus &#40;DM2&#41;&#44; arterial hypertension&#44; dyslipidemia and the syndrome of apnoea obstructing sleep&#46; All of these factors would justify the increase in cardiovascular risk&#44; leading to higher rates of mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Likewise&#44; in recent years a clear association has been found between obesity and the risk of certain neoplasms&#44; including those of the colon and rectum&#44; the breast in post-menopausal women&#44; as well as the endometrium&#44; kidneys&#44; oesophagus and pancreas&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Obesity-associated lipid profile alterations</span><p id="par0025" class="elsevierStylePara elsevierViewall">Dyslipidemia caused by obesity is characterised by quantitative and qualitative lipoprotein alterations&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> The lipid profile alterations found in patients with a high BMI are similar to those found in insulin-resistant patients with DM2&#46; The reduced capacity of insulin to inhibit the production of glucose by the liver&#44; as well as favouring the use of glucose by the muscles&#44; leads to a state of hyperglycemia and hyperinsulinemia&#46; Nor is insulin able to inhibit lipolysis of the triglycerides by the lipase lipoprotein in the adipose tissue&#44; so that the flow of adipocyte-free fatty acids to the liver increases&#44; leading to an increase in visceral fat&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The increase in fatty acids&#44; chiefly in the liver and muscles&#44; with a reduction in the peripheral absorption of the same&#44; leads to an increase in the hepatic synthesis of very low density lipoproteins &#40;VLDL&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Finally&#44; the state of hyperinsulinemia and hyperglycemia also stimulates lipogenesis <span class="elsevierStyleItalic">de novo</span> due to the activation of SREBP-1 protein&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">All of these physiopathological changes give rise to the characteristic lipid profile of patients with obesity&#44; consistent with a reduction in high density cholesterol lipoproteins &#40;HDL&#41;&#44; hypertriglyceridemia and an increase in the number of small dense low density lipoprotein &#40;LDL&#41; particles&#44; known as atherogenic dyslipidemia &#40;AD&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Cardiovascular risk associated with atherogenic dyslipidemia</span><p id="par0040" class="elsevierStylePara elsevierViewall">LDL cholesterol is not only a cardiovascular risk factor&#44; as it is also considered to be a causal factor of atherosclerosis&#46; This is why it is the main therapeutic target in cardiovascular risk prevention guides&#46; These mainly centre their recommendations on LDL cholesterol targets<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> or treatment using statins&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> which are considered to be the first line of treatment for patients with hypercholesterolemia&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Nevertheless&#44; it seems that patients con obesity&#44; even with LDL cholesterol levels at therapeutic target levels&#44; have a residual cardiovascular risk of from 65&#37; to 80&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> This residual risk can be explained&#44; at least in part&#44; by the characteristic AD of this group of patients&#46; On the other hand&#44; small dense particles of LDL&#44; which are also components of AD&#44; play an important role in the onset and progression of atherosclerosis&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In spite of the close association between obesity and this atherogenic profile&#44; AD is often under-diagnosed&#44; under-treated and therefore under-controlled&#46; In the lipid units in our area&#44; of a total of 1649 patients&#44; 36&#46;6&#37; had high levels of triglycerides and 36&#46;1&#37; had low levels of HDL cholesterol&#44; while 18&#37; had both alterations&#46; However&#44; only 16&#37; of the patients achieved the therapeutic objectives&#44; and the predictive factors for success were weight and glycemic profile normalisation&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> This would be explained in part by the prioritisation of the therapeutic targets for LDL cholesterol in preventing cardiovascular risk while regarding the AD profile as secondary&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Bariatric surgery</span><p id="par0055" class="elsevierStylePara elsevierViewall">Bariatric surgery &#40;BS&#41; is considered to be the most effective treatment for patients with morbid obesity&#44; as it brings about a weight loss that may surpass 30&#37;&#44; and which is maintained over the long term&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> This percentage is far higher than is the case for the results of medical treatment that emphasises lifestyle changes&#44; achieving a weight loss of from 5&#37; to 10&#37;&#44; although normally there is a gradual gain in weight over one to two years&#46; In the LOOK AHEAD<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> study&#44; which analysed the effect of a therapeutic strategy centring on lifestyle modification&#44; only 34&#46;5&#37; of the intervention group lost 10&#37; of weight in the first year&#44; and only 42&#46;4&#37; of those who had a satisfactory initial response kept this weight loss 4 years later&#46; On the other hand&#44; pharmacological treatment for obesity achieved weight losses of from 4&#37; to 11&#37;&#59; these figures are lower than those for BS&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">It has to be said that the role of BS goes beyond the said weight loss&#46; It has also been shown to bring about an improvement or remission in different comorbidities after surgery&#46; A meta-analysis by Buchwald et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> in 2004 included data from 136 studies with a total of 22&#44;094 patients&#46; 72&#46;6&#37; of the patients were women&#44; with an average age of 39 years old &#40;16&#8211;64 years old&#41; and an average BMI of 46&#46;9&#8239;kg&#47;m<span class="elsevierStyleSup">2</span> &#40;32&#46;3&#8211;68&#46;8&#8239;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#46; A significant weight loss was observed in the patients with obesity who were subjected to BS&#44; with improvement or resolution of 86&#37; and 70&#37; in DM2 and dyslipidemia&#44; respectively &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">All of these beneficial effects of BS led to a reduction in mortality of almost 30&#37; at 10 years&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> possibly because of a reduction in cardiovascular risk&#46;</p><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Bariatric surgery techniques</span><p id="par0070" class="elsevierStylePara elsevierViewall">The surgical techniques used in the field of BS may be classified as malabsorptive&#44; restrictive and mixed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Malabsorptive techniques such as the biliopancreatic diversion reduce intestinal length and therefore reduce nutrient absorption&#46; Although these techniques give greater weight loss over the long term&#44; they are now used less often due to the risk of nutritional deficits&#44; and because of the higher rate of morbimortality associated with the procedure&#46; On the other hand&#44; use of purely restrictive techniques such as an adjustable gastric band or ringed vertical gastroplasty is limited because of their results in terms of weight loss or the remission of comorbidities&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">The most widely used techniques now are laparoscopic Roux-en-Y gastric bypass &#40;LRYGB&#41; and laparoscopic tubular gastrectomy &#40;LTG&#41;&#44; due to their short-term results in terms of weight loss and resolution of the comorbidities associated with obesity&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> LRYGB is a mixed technique that combines partial exclusion of the stomach by means of gastroplasty with a bypass of the duodenum with the proximal jejunum&#44; with the resulting effect of malabsorption&#46; For many years this has been considered to be the technique of choice due to its good results&#44; with a better balance between efficacy and adverse effects&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> It also seems that its efficacy is determined by other mechanisms which go beyond the weight loss observed after this surgical procedure&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Different alterations have been observed in the gastrointestinal hormones associated with satiety and ingestion after LRYGB&#46; On the one hand&#44; there is an increase in hormones with an incretin effect&#44; such as the peptide similar to type 1 glucagon &#40;GLP-1&#41; and the YY &#40;PYY&#41; peptide over the short term after surgery&#44; and their levels remain high over the long term&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> Among other functions&#44; the incretin hormones favour insulin secretion and delay gastric emptying&#44; contributing positively to weight loss and improved carbon hydrate metabolism&#46; Other hormones are modified after del LRYGB&#44; as described in detail in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">The concentration of biliary acids also increases after LRYGB&#44;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> and on the other hand&#44; alterations have been described&#44; mainly in animal models&#44; in the intestinal microbiota after this procedure&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">LTG is a technique that was performed for the first time in 1988 as a variant of the biliopancreatic diversion with a duodenal switch&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> Subsequently&#44; at the beginning of the 21st century its use was based on first step surgery before using a malabsorptive technique in patients with extreme obesity &#40;BMI&#8239;&#62;&#8239;50&#8239;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> A second operation was unnecessary for the majority of patients&#44; given the good weight loss results&#46; LTG therefore became an operation that was definitive in many cases&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> LTG consists of a subtotal vertical gastrectomy with preservation of the pylorus&#44; including a longitudinal resection of the <span class="elsevierStyleItalic">fundus</span>&#44; the gastric body and antrum&#46; The resection compromises approximately 80&#37; of the stomach&#44; with a gastric remnant of &#62;100&#8239;ml&#46; It is considered to be the simplest surgical technique in comparison with others&#44; such as LRYGB&#44; as it requires less anastomosis and has a lower rate of complications&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Although LTG is a restrictive technique&#44; it has obtained better results than other restrictive techniques&#44; similar to LRYGB in terms of weight loss and the short-term remission of certain comorbidities&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> This may be attributed to different mechanisms that go beyond the restrictive component&#46; Some of the factors described&#44; in a similar way to LRYGB&#44; are associated with modifications to intestinal motility&#44; hormonal mechanisms and alterations in the biliary acids or intestinal microbiota&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">LTG is now considered to be far more than a restrictive technique&#44; and it overtook LRYGB in 2014 to become the most widely used technique in the world&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> In Spain&#44; LTG has progressed from representing 0&#46;8&#37; of all cases of BS to become the second most widely used&#44; at 39&#46;6&#37;&#44; and it is only surpassed by LRYGB&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> Nevertheless&#44; although the medium to long-term results for LRYGB are well-known&#44; this is not the case for LTG&#44; as it is a relatively new technique&#44; so that it has yet to be confirmed whether these techniques are equivalent by longer clinical follow-up studies&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">The effects of bariatric surgery on the evolution of the lipid profile</span><p id="par0105" class="elsevierStylePara elsevierViewall">BS is universally acknowledged to be better than conservative medical treatment in terms of weight loss and the remission of several comorbidities&#44; with the resulting reduction in cardiovascular risk&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">In the case of dyslipidemia&#44; the meta-analysis by Buchwald et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> found an improvement or resolution of 70&#37;&#44; with similar results to those of previous studies that evaluated the overall remission of dyslipidemia&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">31&#44;32</span></a> This gives rise to certain limitations&#44; as firstly there is no unanimous agreement on the definition of the remission of dyslipidemia&#44; so that the results of different studies are not always comparable&#46; Secondly&#44; the fact that dyslipidemia is evaluated as a whole means that the evolution of different lipid fractions is not taken into account&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">On the other hand&#44; and as was pointed out above&#44; the characteristic lipid alteration in patients with obesity is composed of reduced levels of HDL cholesterol and hypertriglyceridemia&#46; The evaluation of this atherogenic profile after BS is indispensible&#44; as it may explain the reduction in residual cardiovascular risk shown by these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a> Thus previous studies have observed a fall of from 30&#37; to 63&#37; and an increase of from 12&#37; to 39&#37; in triglycerides and HDL cholesterol&#44; respectively&#44; after BS&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">34&#44;35</span></a> Similarly&#44; a study by our group evaluated the remission of AD one year after LRYGB and LTG&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> AD was present in 81 of 356 patients &#40;22&#46;8&#37;&#41;&#44; and in 74&#46;1&#37; remission occurred by 3 months and 90&#46;1&#37; at 6 months&#44; reaching 96&#46;3&#37;&#8239;at 12 months after the surgical procedure&#46; Likewise&#44; HDL cholesterol rose 6 months after BS in both groups &#40;with and without AD&#41;&#44; with a significantly greater increase in the atherogenic profile group &#40;47&#46;6&#8239;&#177;&#8239;31&#46;6 versus 24&#46;1&#8239;&#177;&#8239;23&#46;2&#37;&#44; respectively&#59; <span class="elsevierStyleItalic">P</span>&#8239;&#60;&#8239;&#46;001&#41;&#46; There was also an evident improvement in triglycerides in the first three months after surgery in both groups&#44; with a significantly greater reduction in the group with AD during the entire follow-up period &#40;49&#46;3&#8239;&#177;&#8239;21&#46;3 versus 21&#46;2&#8239;&#177;&#8239;53&#46;0&#37;&#44; respectively&#59; <span class="elsevierStyleItalic">P</span>&#8239;&#60;&#8239;&#46;001&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Differences between LRYGB and LTG in terms of lipid profile evolution</span><p id="par0120" class="elsevierStylePara elsevierViewall">Regarding the different techniques of BS&#44; in the majority of studies LRYGB and LTG obtained comparable results in terms of weight loss and the remission of several associated diseases over the short to medium term&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">37&#8211;40</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">It seems that the difference between both surgical procedures may lie in their effect on the lipid profile&#46; Thus&#44; in studies with a short follow-up period LRYGB has been said to be superior to LTG in how it improves concentrations of total cholesterol and LDL cholesterol&#46;<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">41&#44;42</span></a> However&#44; the short-term results for triglycerides and HDL are contradictory&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">43&#44;44</span></a> One study by our group<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a> with a one-year follow-up included 51 patients treated by LRYGB and 51 treated by LTG&#46; The results concluded that the mixed technique improved all of the lipid fractions&#44; while the restrictive technique&#44; although it had no effect on LDL cholesterol levels&#44; had the same or more effect as the malabsorptive techniques in increasing HDL cholesterol&#46; On the contrary&#44; the study by Vix et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">46</span></a> which included 45 patients in the LRYGB group and 55 in the LTG group&#44; with a one-year follow-up&#44; found that the first group performed better in reducing total and LDL cholesterol and raising HDL cholesterol&#44; with no differences between the techniques respecting triglyceridemia&#46; Given the heterogeneous results of comparing lipid profile evolution after LRYGB or LTG over the short term&#44; our group decided to compare the different studies published to date in a meta-analysis&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">47</span></a> A total of 17 papers were included &#40;4 randomised clinical trials&#44; 6 cohort studies and 7 control cases&#41;&#46; Hypercholesterolemia remission was greater after LRYGB than it was after LTG &#40;relative risk&#58; 1&#46;43&#59; CI&#8239;95&#37;&#58; 1&#46;27&#8211;1&#46;61&#41;&#44; and no differences were found between the two surgical techniques in hypertriglyceridemia evolution &#40;relative risk&#58; 1&#46;11&#59; CI&#8239;95&#37;&#58; 1&#46;00&#8211;1&#46;23&#41; or low HDL cholesterol &#40;relative risk&#58; 0&#46;96&#59; CI&#8239;95&#37;&#58; 0&#46;02&#8211;57&#46;28&#41;&#46; The change in the concentration of different lipid fractions was also evaluated&#46; LRYGB was superior to LTG in terms of the reduction in total cholesterol &#40;average difference&#58; 19&#46;77&#8239;mg&#47;dl&#59; CI&#8239;95&#37;&#58; 11&#46;84&#8211;27&#46;69&#41;&#46; A greater fall was also detected in LDL cholesterol after LRYGB in comparison with LTG &#40;average difference&#58; 19&#46;29&#8239;mg&#47;dl&#59; CI&#8239;95&#37;&#58; 11&#46;93&#8211;26&#46;64&#41;&#46; On the other hand both surgical techniques were similar in terms of their results for triglycerides &#40;average difference&#58; &#8722;1&#46;19&#8239;mg&#47;dl&#59; CI&#8239;95&#37;&#58; &#8722;10&#46;99 to 8&#46;60&#41;&#44; as well as the rise in HDL cholesterol concentration &#40;average difference&#58; &#46;47&#8239;mg&#47;dl&#44; CI&#8239;95&#37;&#58; &#8722;1&#46;43 to 2&#46;37&#41;&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Furthermore&#44; very few studies compare LRYGB to LTG over 5 years in terms of lipid profile evolution&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">48&#44;49</span></a> The majority evaluated the overall remission of dyslipidemia&#44; as did Zhang et al&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">50</span></a> They found a remission of 92&#46;3&#37; and 84&#46;6&#37; at 5 years after LRYGB and LTG&#44; respectively&#44; although the differences were not significant&#46; Other studies evaluated changes in the concentrations of different lipid fractions after BS&#46; Thus the recently published randomised clinical trial SLEEVEPASS<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">51</span></a> &#40;119 patients treated by LRYGB and 121 by LTG&#41; found lower levels of LDL cholesterol LDL 5 years after LRYGB in comparison with LTG &#40;96&#46;5&#8239;mg&#47;dl versus 104&#46;3&#8239;mg&#47;dl&#59; <span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;02&#41;&#46; Likewise&#44; the SM-BOSS<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">52</span></a> study &#40;with 110 patients operated using LRYGB and 107 using LTG&#41;&#44; and following the same line&#44; also found a greater reduction in LDL cholesterol after the mixed technique in comparison with the restrictive technique &#40;101&#46;1&#8239;mg&#47;dl versus 116&#46;1&#8239;mg&#47;dl&#59; <span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;008&#41;&#46; However&#44; neither study found differences between the techniques respecting other lipid fractions&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Finally&#44; a recent study by our group<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">53</span></a> compared the results 5 years after LRYGB and LTG&#46; This evaluated the change in concentration as well as the remission of hypercholesterolemia&#44; hypertriglyceridemia and low HDL cholesterol&#46; 151 of the 259 patients &#40;58&#46;3&#37;&#41; completed 5 years of follow-up&#44; of whom 103 &#40;68&#46;2&#37;&#41; had received LRYGB and 48 &#40;31&#46;8&#37;&#41; LTG&#46; Hypercholesterolemia remission &#40;26&#47;58 &#91;44&#46;8&#37;&#93; versus 6&#47;26 &#91;23&#46;1&#37;&#93;&#59; <span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;047&#41; as well as high LDL cholesterol &#40;30&#47;49 &#91;61&#46;2&#37;&#93; versus 6&#47;23 &#91;26&#46;1&#37;&#93;&#59; <span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;005&#41; at 5 years were all greater after LRYGB than they were after LTG&#46; Nevertheless&#44; the number of patients who achieved normal levels of HDL cholesterol at 5 years after surgery was similar in both techniques &#40;39&#47;47 &#91;83&#46;0&#37;&#93; and 18&#47;23 &#91;78&#46;3&#37;&#93; after LRYGB and LTG&#44; respectively&#59; <span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;633&#41;&#46; Hypertriglyceridemia remission at 5 years was greater after LRYGB than it was after LTG &#40;23&#47;25 &#91;92&#46;0&#37;&#93; versus 10&#47;15 &#91;66&#46;7&#37;&#93;&#59; <span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;041&#41;&#46; However&#44; LTG showed a higher rate of relapse during follow-up&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Factors associated with the remission of lipid profile alterations</span><p id="par0140" class="elsevierStylePara elsevierViewall">Finally&#44; little is known about the factors associated with changes in the lipid profile after BS&#46; Regarding this&#44; and with a follow-up of one year&#44; a study by our group<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a> found that at a younger age&#44; concentrations of total cholesterol and LRYGB were associated with improvement in total cholesterol&#46; The same factors &#40;except age&#41; were found to be associated with a reduction in LDL cholesterol levels&#46; Regarding HDL cholesterol&#44; a rise in its levels after BS was associated with an older age&#44; initial levels of HDL cholesterol and the LTG procedure&#46; A reduction in triglyceride levels was associated with basal triglyceride levels and HbA1c&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Another study by our group that was cited above<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">53</span></a> evaluated factors associated with the remission of different lipid profile alterations at 5 years&#46; Thus the factors associated with the remission of hypercholesterolemia were male sex&#44; LRYGB and the absence of initial treatment with statins&#46; The absence of initial treatment with fibrates and the percentage of weight loss after 60 months were associated with the remission of hypertriglyceridemia&#44; and this was the only factor associated with the remission of low HDL cholesterol&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conclusions</span><p id="par0150" class="elsevierStylePara elsevierViewall">A range of associated comorbidities are present in patients with obesity&#46; They include AD&#44; which causes the high residual cardiovascular risk in these patients&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">On the other hand&#44; BS has been shown to be the most effective treatment for obesity&#44; and LRYGB and LTG are now the most widely used techniques&#46; Both procedures have given similar results in terms of weight loss and the remission of several comorbidities&#46; Nevertheless&#44; for the lipid profile it seems that LRYGB is superior to LTG regarding the evolution of plasma concentrations of total and LDL cholesterol&#46; However&#44; the results for HDL cholesterol and triglycerides are contradictory&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Further randomised studies with a longer clinical follow-up are therefore required&#44; to confirm the preliminary results obtained and thereby underline any possible differences between both surgical procedures regarding the evolution of the lipid profile&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Financing</span><p id="par0165" class="elsevierStylePara elsevierViewall">This study received no specific support from agencies in the public sector&#44; the commercial sector or not-for-profit organisations&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conflict of interests</span><p id="par0170" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:13 [
        0 => array:3 [
          "identificador" => "xres1320692"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1218390"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres1320691"
          "titulo" => "Resumen"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0010"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1218391"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Definition and epidemiology of obesity"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Obesity-associated lipid profile alterations"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Cardiovascular risk associated with atherogenic dyslipidemia"
        ]
        7 => array:3 [
          "identificador" => "sec0020"
          "titulo" => "Bariatric surgery"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Bariatric surgery techniques"
            ]
            1 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "The effects of bariatric surgery on the evolution of the lipid profile"
            ]
            2 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Differences between LRYGB and LTG in terms of lipid profile evolution"
            ]
          ]
        ]
        8 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Factors associated with the remission of lipid profile alterations"
        ]
        9 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Conclusions"
        ]
        10 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Financing"
        ]
        11 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Conflict of interests"
        ]
        12 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2019-07-17"
    "fechaAceptado" => "2019-11-11"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1218390"
          "palabras" => array:4 [
            0 => "Laparoscopic Roux-en-Y gastric bypass"
            1 => "Bariatric surgery"
            2 => "Dyslipidemia"
            3 => "Laparoscopic sleeve gastrectomy"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1218391"
          "palabras" => array:4 [
            0 => "Bypass g&#225;strico laparosc&#243;pico en Y de Roux"
            1 => "Cirug&#237;a bari&#225;trica"
            2 => "Dislipemia"
            3 => "Gastrectom&#237;a tubular laparosc&#243;pica"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Obesity prevalence has presented an exponential increase in the last decades&#44; becoming a first order public health issue&#46; Dyslipidemia of obesity&#44; characterised by low levels of high density lipoprotein &#40;HDL&#41; cholesterol&#44; hypertriglyceridemia and small and dense low-density lipoprotein &#40;LDL&#41; particles&#44; is partly responsible for the high residual cardiovascular risk of this clinical situation&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">On the other hand&#44; bariatric surgery &#40;BS&#41; is the most effective treatment for obesity&#44; obtaining a greater weight loss than achieved with conventional medical therapy and favouring the improvement or remission of associated comorbidities&#46; The most commonly used BS techniques nowadays are laparoscopic Roux-en-Y gastric bypass &#40;LRYGB&#41; and laparoscopic sleeve gastrectomy &#40;LSG&#41;&#46; Both of these procedures have obtained similar results in terms of weight loss and comorbidity remission such as type 2 diabetes mellitus or hypertension&#46;</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">A differential feature between both techniques could be the different impact on the lipoprotein profile&#46; In this respect&#44; previous studies with short and mid-term follow-up have proved LRYGB to be superior to LSG in total and LDL cholesterol reduction&#46; Results regarding triglycerides and HDL cholesterol are contradictory&#46; Therefore&#44; we consider of interest to review the effects of BS at short and mid-term follow-up on lipoprotein profile&#44; as well as the remission rates of the different lipid abnormalities and the possible related factors&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">La prevalencia de la obesidad ha aumentado de manera exponencial en las &#250;ltimas d&#233;cadas&#44; convirti&#233;ndose en un problema de salud p&#250;blica de primer orden&#46; La dislipemia de la obesidad&#44; caracterizada por niveles bajos de colesterol de las lipoprote&#237;nas de alta densidad &#40;HDL&#41;&#44; hipertrigliceridemia y part&#237;culas peque&#241;as y densas de lipoprote&#237;nas de baja densidad &#40;LDL&#41;&#44; es responsable en parte del elevado riesgo cardiovascular residual de esta situaci&#243;n cl&#237;nica&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Por otro lado&#44; la cirug&#237;a bari&#225;trica &#40;CB&#41; es el tratamiento m&#225;s eficaz para la obesidad&#44; obteniendo una mayor p&#233;rdida ponderal que con el tratamiento m&#233;dico convencional y favoreciendo la mejor&#237;a o remisi&#243;n de las comorbilidades asociadas&#46; Las t&#233;cnicas de CB m&#225;s utilizadas en la actualidad son el bypass g&#225;strico laparosc&#243;pico en Y de Roux &#40;BGYRL&#41; y la gastrectom&#237;a tubular laparosc&#243;pica &#40;GTL&#41;&#46; &#201;stas han obtenido resultados similares tanto en cuanto a la p&#233;rdida de peso como a la remisi&#243;n de ciertas comorbilidades como la diabetes mellitus tipo 2 o la hipertensi&#243;n arterial&#46;</p><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Un rasgo diferencial entre ambas t&#233;cnicas podr&#237;a ser el diferente impacto sobre el perfil lipoproteico&#46; As&#237;&#44; estudios previos con seguimiento a corto y medio plazo han objetivado una superioridad del BGYRL frente a la GTL en la reducci&#243;n del colesterol total y LDL&#46; Existen resultados discordantes en cuanto a la evoluci&#243;n del colesterol HDL y los triglic&#233;ridos&#46; Por todo ello&#44; hemos considerado de inter&#233;s revisar los efectos de la CB a corto y medio plazo en el perfil lipoproteico&#44; as&#237; como las tasas de remisi&#243;n de las diferentes alteraciones lip&#237;dicas y los posibles factores relacionados&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Climent E&#44; Benaiges D&#44; Goday A&#44; Villatoro M&#44; Juli&#224; H&#44; Ram&#243;n JM&#44; et al&#46; Obesidad m&#243;rbida y dislipemia&#58; impacto de la cirug&#237;a bari&#225;trica&#46; An Pediatr &#40;Barc&#41;&#46; 2020&#46; <span class="elsevierStyleInterRef" id="intr0005" href="https://doi.org/10.1016/j.arteri.2019.11.001">https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;arteri&#46;2019&#46;11&#46;001</span></p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1625
            "Ancho" => 2167
            "Tamanyo" => 184874
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Types of bariatric surgical techniques&#46; Adapted from Pories WJ&#46; Bariatric surgery&#58; Risks and rewards&#46; J Clin Endocrinol Metab&#46; 2008&#59;93&#58;S89-96&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">DM2&#58; type II diabetes mellitus&#59; AHT&#58; arterial hypertension&#59; PEWL&#58; percentage of excess weight loss&#59; SOSA&#58; syndrome of obstructive sleep apnoea&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Source&#58; Buchwald et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Adjustable gastric band&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vertical ring gastroplasty&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Roux-en-Y gastric bypass&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Biliopancreatic diversion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Percentage of PEWL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Remission of DM2 &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">97&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Remission of AHT &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">81&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Remission of SOSA &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">94&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">95&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Improvement in dyslipidemia &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">71&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">99&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2263608.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Main findings of the meta-analysis by Buchwald et al&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">LRYGB&#58; laparoscopic Roux-en-Y gastric bypass&#59; GIP&#58; gastric inhibitor peptide&#59; GLP-1&#58; glucagon-like peptide type 1&#59; PYY&#58; YY peptide&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Adapted from Ramos Lev&#237; AM&#44; Rubio Herrera MA&#46; Cirug&#237;a metab&#243;lica&#46; In&#58; Bellido D&#44; et al&#46; Sobrepeso y obesidad&#46; Sociedad Espa&#241;ola para el estudio de la obesidad&#46; Madrid&#59; 2015&#46; pp&#46; 603&#8211;620&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Hormone&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Origin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Normal action&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Secretion after LRYGB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ghrelin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gastric <span class="elsevierStyleItalic">fundus</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Orexigenic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8595; &#40;heterogeneous results&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8593; GH&#44; cortisol&#44; epinephrine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8595; adiponectin&#44; glucose sensitivity&#44; insulin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GLP-1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">L cells&#44; distal ileum and colon&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8593; insulin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8593; &#40;results of the majority of studies agree&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8595; glucagon&#44; gastric emptying&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8593; satiety&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GIP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">K cells duodenum and jejunum&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8593; insulin&#44; glucagon&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8593; &#40;heterogeneous results&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8595; lipolysis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Oxyntomodulin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">L cells&#44; distal intestine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Slows gastric emptying&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8593; &#40;similar to GLP-1&#8239;&#43;&#8239;PYY&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8595; pancreatic exocrine secretion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8595; ingestion and weight&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PYY&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">L cells&#44; terminal ileum and colon&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8595; hunger&#8239;&#43;&#8239;ingestion &#40;hypothalamic action&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8593;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Amilin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pancreatic beta cells&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Slows gastric emptying&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8595;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8595; glucagon&#8239;&#43;&#8239;ingestion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Synergic effect with leptin &#8239;&#43;&#8239;PYY&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Insulin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pancreatic beta cells&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anabolic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8595; &#40;but improves sensitivity&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Carbohydrates metabolism&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glucagon&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pancreatic alpha cells&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Catabolic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8593; &#40;transitory and paradoxical&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hyperglycemiant effect&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Leptin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Adipose tissue&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8595; hunger&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8595; &#40;but improves sensitivity&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Adiponectin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Adipose tissue&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8593; insulin sensitivity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8593;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2263609.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Summary of the main actions of the hormones which are altered after LRYGB&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:53 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathophysiology of obesity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Ravussin"
                            1 => "B&#46;A&#46; Swinburn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0140-6736(92)91480-v"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1992"
                        "volumen" => "340"
                        "paginaInicial" => "404"
                        "paginaFinal" => "408"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1353565"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increasing trend in the prevalence of morbid obesity in Spain&#58; from 1&#46;8 to 6&#46;1 per thousand in 14 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46;J&#46; Basterra-Gortari"
                            1 => "J&#46;J&#46; Beunza"
                            2 => "M&#46; Bes-Rastrollo"
                            3 => "E&#46; Toledo"
                            4 => "M&#46; Garc&#237;a-L&#243;pez"
                            5 => "M&#46;A&#46; Mart&#237;nez-Gonz&#225;lez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.recesp.2010.06.010"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Esp Cardiol"
                        "fecha" => "2011"
                        "volumen" => "64"
                        "paginaInicial" => "424"
                        "paginaFinal" => "426"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21411209"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of general and abdominal obesity in the adult population of Spain&#44; 2008-2010&#58; the ENRICA study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;L&#46; Guti&#233;rrez-Fisac"
                            1 => "P&#46; Guallar-Castill&#243;n"
                            2 => "L&#46;M&#46; Le&#243;n-Mu&#241;oz"
                            3 => "A&#46; Graciani"
                            4 => "J&#46;R&#46; Banegas"
                            5 => "F&#46; Rodr&#237;guez-Artalejo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1467-789X.2011.00964.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Obes Rev"
                        "fecha" => "2012"
                        "volumen" => "13"
                        "paginaInicial" => "388"
                        "paginaFinal" => "392"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22151906"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of general obesity and abdominal obesity in the Spanish adult population &#40;aged 25-64 years&#41; 2014-2015&#58; the ENPE study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Aranceta-Bartrina"
                            1 => "C&#46; P&#233;rez-Rodrigo"
                            2 => "G&#46; Alberdi-Aresti"
                            3 => "N&#46; Ramos-Carrera"
                            4 => "S&#46; L&#225;zaro-Masedo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.rec.2016.02.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Esp Cardiol"
                        "fecha" => "2016"
                        "volumen" => "69"
                        "paginaInicial" => "579"
                        "paginaFinal" => "587"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27133458"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obesity&#44; metabolic syndrome&#44; and cardiovascular disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46;M&#46; Grundy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jc.2004-0372"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2004"
                        "volumen" => "89"
                        "paginaInicial" => "2595"
                        "paginaFinal" => "2600"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15181029"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obesity as a risk factor in cancer&#58; A national consensus of the Spanish Society for the Study of Obesity and the Spanish Society of Medical Oncology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Goday"
                            1 => "I&#46; Barneto"
                            2 => "J&#46;M&#46; Garc&#237;a-Almeida"
                            3 => "A&#46; Blasco"
                            4 => "A&#46; Lecube"
                            5 => "C&#46; Gr&#225;valos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s12094-015-1306-y"
                      "Revista" => array:7 [
                        "tituloSerie" => "Clin Transl Oncol"
                        "fecha" => "2015"
                        "volumen" => "17"
                        "paginaInicial" => "763"
                        "paginaFinal" => "771"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26036853"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0735109714015587"
                          "estado" => "S300"
                          "issn" => "07351097"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obesity and dyslipidemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46; Franssen"
                            1 => "H&#46; Monajemi"
                            2 => "E&#46;S&#46;G&#46; Stroes"
                            3 => "J&#46;J&#46;P&#46; Kastelein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.mcna.2011.06.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Clin North Am"
                        "fecha" => "2011"
                        "volumen" => "95"
                        "paginaInicial" => "893"
                        "paginaFinal" => "902"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21855698"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human fat cell lipolysis&#58; biochemistry&#44; regulation and clinical role"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; Arner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.beem.2005.07.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Best Pract Res Clin Endocrinol Metab"
                        "fecha" => "2005"
                        "volumen" => "19"
                        "paginaInicial" => "471"
                        "paginaFinal" => "482"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16311212"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metabolic syndrome&#58; focus on dyslipidemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46;N&#46; Ginsberg"
                            1 => "Y&#46;-L&#46; Zhang"
                            2 => "A&#46; Hernandez-Ono"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/oby.2006.281"
                      "Revista" => array:8 [
                        "tituloSerie" => "Obesity"
                        "fecha" => "2006"
                        "volumen" => "14"
                        "numero" => "2 Suppl"
                        "paginaInicial" => "41S"
                        "paginaFinal" => "49S"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16642962"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S016752731736850X"
                          "estado" => "S300"
                          "issn" => "01675273"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Small LDL&#44; atherogenic dyslipidemia&#44; and the metabolic syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46;M&#46; Grundy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.cir.95.1.1"
                      "Revista" => array:7 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1997"
                        "volumen" => "95"
                        "paginaInicial" => "1"
                        "paginaFinal" => "4"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8994405"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1885585717304280"
                          "estado" => "S300"
                          "issn" => "18855857"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "2016 European guidelines on cardiovascular disease prevention in clinical practice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;F&#46; Piepoli"
                            1 => "A&#46;W&#46; Hoes"
                            2 => "S&#46; Agewall"
                            3 => "C&#46; Albus"
                            4 => "C&#46; Brotons"
                            5 => "A&#46;L&#46; Catapano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/eurheartj/ehw106"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2016"
                        "volumen" => "37"
                        "paginaInicial" => "2315"
                        "paginaFinal" => "2381"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27222591"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "2013 ACC&#47;AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46;J&#46; Stone"
                            1 => "J&#46;G&#46; Robinson"
                            2 => "A&#46;H&#46; Lichtenstein"
                            3 => "C&#46;N&#46; Bairey Merz"
                            4 => "C&#46;B&#46; Blum"
                            5 => "R&#46;H&#46; Eckel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2013.11.002"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2014"
                        "volumen" => "63"
                        "paginaInicial" => "2889"
                        "paginaFinal" => "2934"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24239923"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0190962218303256"
                          "estado" => "S300"
                          "issn" => "01909622"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The residual risk reduction initiative&#58; a call to action to reduce residual vascular risk in dyslipidaemic patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;-C&#46; Fruchart"
                            1 => "F&#46;M&#46; Sacks"
                            2 => "M&#46;P&#46; Hermans"
                            3 => "G&#46; Assmann"
                            4 => "W&#46;V&#46; Brown"
                            5 => "R&#46; Ceska"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Diabetes Vasc Dis Res"
                        "fecha" => "2008"
                        "volumen" => "5"
                        "paginaInicial" => "319"
                        "paginaFinal" => "335"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Atherogenic modified LDL in diabetes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "I&#46;A&#46; Sobenin"
                            1 => "V&#46;V&#46; Tertov"
                            2 => "A&#46;N&#46; Orekhov"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2337/diab.45.3.s35"
                      "Revista" => array:7 [
                        "tituloSerie" => "Diabetes"
                        "fecha" => "1996"
                        "volumen" => "45"
                        "numero" => "Suppl&#46; 3"
                        "paginaInicial" => "S35"
                        "paginaFinal" => "9"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8674887"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dislipemia aterog&#233;nica&#58; prevalencia y control en las unidades de l&#237;pidos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Pedro-Botet"
                            1 => "J&#46;A&#46; Flores-Le Roux"
                            2 => "J&#46;M&#46; Mostaza"
                            3 => "X&#46; Pint&#243;"
                            4 => "J&#46;J&#46; de la Cruz"
                            5 => "J&#46;R&#46; Banegas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.rce.2014.06.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Cl&#237;n Esp"
                        "fecha" => "2014"
                        "volumen" => "214"
                        "paginaInicial" => "491"
                        "paginaFinal" => "498"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25016414"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lifestyle&#44; diabetes&#44; and cardiovascular risk factors 10 years after bariatric surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Sj&#246;str&#246;m"
                            1 => "A&#46;-K&#46; Lindroos"
                            2 => "M&#46; Peltonen"
                            3 => "J&#46; Torgerson"
                            4 => "C&#46; Bouchard"
                            5 => "B&#46; Carlsson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa035622"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2004"
                        "volumen" => "351"
                        "paginaInicial" => "2683"
                        "paginaFinal" => "2693"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15616203"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Eight-year weight losses with an intensive lifestyle intervention&#58; the look AHEAD study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Look AHEAD Research Group"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/oby.20662"
                      "Revista" => array:6 [
                        "tituloSerie" => "Obesity"
                        "fecha" => "2014"
                        "volumen" => "22"
                        "paginaInicial" => "5"
                        "paginaFinal" => "13"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24307184"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bariatric surgery&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Buchwald"
                            1 => "Y&#46; Avidor"
                            2 => "E&#46; Braunwald"
                            3 => "M&#46;D&#46; Jensen"
                            4 => "W&#46; Pories"
                            5 => "K&#46; Fahrbach"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.292.14.1724"
                      "Revista" => array:7 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2004"
                        "volumen" => "292"
                        "paginaInicial" => "1724"
                        "paginaFinal" => "1737"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15479938"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1885585717300713"
                          "estado" => "S300"
                          "issn" => "18855857"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Laparoscopic gastric bypass versus laparoscopic sleeve gastrectomy as a definitive surgical procedure for morbid obesity&#46; Mid-term results"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Vidal"
                            1 => "J&#46;M&#46; Ram&#243;n"
                            2 => "A&#46; Goday"
                            3 => "D&#46; Benaiges"
                            4 => "L&#46; Trillo"
                            5 => "A&#46; Parri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11695-012-0828-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Obes Surg"
                        "fecha" => "2013"
                        "volumen" => "23"
                        "paginaInicial" => "292"
                        "paginaFinal" => "299"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23196992"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanism underlying the weight Loss and complications of Roux-en-Y gastric bypass&#46; Review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Abdeen"
                            1 => "C&#46; le Roux"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11695-015-1945-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Obes Surg"
                        "fecha" => "2016"
                        "volumen" => "26"
                        "paginaInicial" => "410"
                        "paginaFinal" => "421"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26530712"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "GLP-1 response to a mixed meal&#58; what happens 10 years after Roux-en-Y gastric bypass &#40;RYGB&#41;&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;S&#46; Dar"
                            1 => "W&#46;H&#46; Chapman"
                            2 => "J&#46;R&#46; Pender"
                            3 => "A&#46;J&#46; Drake 3rd"
                            4 => "K&#46; O&#8217;Brien"
                            5 => "R&#46;J&#46; Tanenberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11695-012-0624-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Obes Surg"
                        "fecha" => "2012"
                        "volumen" => "22"
                        "paginaInicial" => "1077"
                        "paginaFinal" => "1083"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22419108"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic control"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;J&#46; Pournaras"
                            1 => "C&#46; Glicksman"
                            2 => "R&#46;P&#46; Vincent"
                            3 => "S&#46; Kuganolipava"
                            4 => "J&#46; Alaghband-Zadeh"
                            5 => "D&#46; Mahon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/en.2011-2145"
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocrinology"
                        "fecha" => "2012"
                        "volumen" => "153"
                        "paginaInicial" => "3613"
                        "paginaFinal" => "3619"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22673227"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss&#58; links with metabolic and low-grade inflammation markers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;-P&#46; Furet"
                            1 => "L&#46;-C&#46; Kong"
                            2 => "J&#46; Tap"
                            3 => "C&#46; Poitou"
                            4 => "A&#46; Basdevant"
                            5 => "J&#46;L&#46; Bouillot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2337/db10-0253"
                      "Revista" => array:7 [
                        "tituloSerie" => "Diabetes"
                        "fecha" => "2010"
                        "volumen" => "59"
                        "paginaInicial" => "3049"
                        "paginaFinal" => "3057"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20876719"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1885585715002340"
                          "estado" => "S300"
                          "issn" => "18855857"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biliopancreatic diversion with duodenal switch"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Marceau"
                            1 => "F&#46;S&#46; Hould"
                            2 => "S&#46; Simard"
                            3 => "S&#46; Lebel"
                            4 => "R&#46;A&#46; Bourque"
                            5 => "M&#46; Potvin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s002689900498"
                      "Revista" => array:7 [
                        "tituloSerie" => "World J Surg"
                        "fecha" => "1998"
                        "volumen" => "22"
                        "paginaInicial" => "947"
                        "paginaFinal" => "954"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9717420"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1885585715003552"
                          "estado" => "S300"
                          "issn" => "18855857"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early experience with two-stage laparoscopic Roux-en-Y gastric bypass as an alternative in the super-super obese patient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;P&#46; Regan"
                            1 => "W&#46;B&#46; Inabnet"
                            2 => "M&#46; Gagner"
                            3 => "A&#46; Pomp"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1381/096089203322618669"
                      "Revista" => array:6 [
                        "tituloSerie" => "Obes Surg"
                        "fecha" => "2003"
                        "volumen" => "13"
                        "paginaInicial" => "861"
                        "paginaFinal" => "864"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14738671"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Laparoscopic sleeve gastrectomy as an isolated bariatric procedure&#58; intermediate-term results from a large series in three Austrian centers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;X&#46; Felberbauer"
                            1 => "F&#46; Langer"
                            2 => "S&#46; Shakeri-Manesch"
                            3 => "E&#46; Schmaldienst"
                            4 => "M&#46; Kees"
                            5 => "S&#46; Kriwanek"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11695-008-9483-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Obes Surg"
                        "fecha" => "2008"
                        "volumen" => "18"
                        "paginaInicial" => "814"
                        "paginaFinal" => "818"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18392898"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bariatric surgery versus intensive medical therapy for diabetes-3-year outcomes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;R&#46; Schauer"
                            1 => "D&#46;L&#46; Bhatt"
                            2 => "J&#46;P&#46; Kirwan"
                            3 => "K&#46; Wolski"
                            4 => "S&#46;A&#46; Breathauer"
                            5 => "S&#46;D&#46; Navaneethan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa1401329"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2014"
                        "volumen" => "370"
                        "paginaInicial" => "2002"
                        "paginaFinal" => "2013"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24679060"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metabolic and hormonal changes after laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy&#58; a randomized&#44; prospective trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Peterli"
                            1 => "R&#46;E&#46; Steinert"
                            2 => "B&#46; Woelnerhanssen"
                            3 => "T&#46; Peters"
                            4 => "C&#46; Christoffel-Courtin"
                            5 => "M&#46; Gass"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11695-012-0622-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Obes Surg"
                        "fecha" => "2012"
                        "volumen" => "22"
                        "paginaInicial" => "740"
                        "paginaFinal" => "748"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22354457"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bariatric surgery and endoluminal procedures&#58; IFSO worldwide survey 2014"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Angrisani"
                            1 => "A&#46; Santonicola"
                            2 => "P&#46; Iovino"
                            3 => "A&#46; Vitiello"
                            4 => "N&#46; Zundel"
                            5 => "H&#46; Buchwald"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11695-017-2666-x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Obes Surg"
                        "fecha" => "2017"
                        "volumen" => "27"
                        "paginaInicial" => "2279"
                        "paginaFinal" => "2289"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28405878"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trends in bariatric surgery in Spain in the twenty-first century&#58; baseline results and 1-month follow up of the RICIBA&#44; a national registry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Lecube"
                            1 => "A&#46; de Hollanda"
                            2 => "A&#46; Cala&#241;as"
                            3 => "N&#46; Vilarrasa"
                            4 => "M&#46;A&#46; Rubio"
                            5 => "I&#46; Breton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11695-015-2001-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Obes Surg"
                        "fecha" => "2016"
                        "volumen" => "26"
                        "paginaInicial" => "1836"
                        "paginaFinal" => "1842"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26661106"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Type 2 diabetes mellitus and the metabolic syndrome following sleeve gastrectomy in severely obese subjects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Vidal"
                            1 => "A&#46; Ibarzabal"
                            2 => "F&#46; Romero"
                            3 => "S&#46; Delgado"
                            4 => "D&#46; Mombl&#225;n"
                            5 => "L&#46; Flores"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11695-008-9547-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Obes Surg"
                        "fecha" => "2008"
                        "volumen" => "18"
                        "paginaInicial" => "1077"
                        "paginaFinal" => "1082"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18521701"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A systematic review and meta-analysis of the effect of gastric bypass surgery on plasma lipid levels"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46;A&#46; Carswell"
                            1 => "A&#46;P&#46; Belgaumkar"
                            2 => "S&#46;A&#46; Amiel"
                            3 => "A&#46;G&#46; Patel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11695-015-1829-x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Obes Surg"
                        "fecha" => "2016"
                        "volumen" => "26"
                        "paginaInicial" => "843"
                        "paginaFinal" => "855"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26210195"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dislipidemia aterog&#233;nica y riesgo residual&#46; Estado de la cuesti&#243;n en 2014"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Mill&#225;n N&#250;&#241;ez-Cort&#233;s"
                            1 => "J&#46; Pedro-Botet Montoya"
                            2 => "X&#46; Pint&#243; Sala"
                            3 => "Residual risk reduction initiative y grupo de trabajo sobre dislipemia aterog&#233;nica"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cl&#237;n Invest Arterioscler"
                        "fecha" => "2014"
                        "volumen" => "26"
                        "paginaInicial" => "287"
                        "paginaFinal" => "292"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of weight loss&#44; induced by gastric bypass surgery&#44; on HDL remodeling in obese women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46;F&#46; Asztalos"
                            1 => "M&#46;M&#46; Swarbrick"
                            2 => "E&#46;J&#46; Schaefer"
                            3 => "G&#46;E&#46; Dallal"
                            4 => "K&#46;V&#46; Horvath"
                            5 => "M&#46; Ai"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1194/jlr.P900015"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Lipid Res"
                        "fecha" => "2010"
                        "volumen" => "51"
                        "paginaInicial" => "2405"
                        "paginaFinal" => "2412"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20631298"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of bariatric surgery on inflammatory&#44; functional and structural markers of coronary atherosclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Habib"
                            1 => "J&#46;D&#46; Scrocco"
                            2 => "M&#46; Terek"
                            3 => "V&#46; Vanek"
                            4 => "J&#46;R&#46; Mikolich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2009.06.042"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2009"
                        "volumen" => "104"
                        "paginaInicial" => "1251"
                        "paginaFinal" => "1255"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19840571"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Atherogenic dyslipidemia remission 1 year after bariatric surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Climent"
                            1 => "D&#46; Benaiges"
                            2 => "J&#46; Pedro-Botet"
                            3 => "J&#46;A&#46; Flores-Le Roux"
                            4 => "J&#46;M&#46; Ram&#243;n"
                            5 => "M&#46; Villatoro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11695-016-2504-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Obes Surg"
                        "fecha" => "2016"
                        "volumen" => "27"
                        "paginaInicial" => "1548"
                        "paginaFinal" => "1553"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27988827"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Weight loss outcomes in laparoscopic vertical sleeve gastrectomy &#40;LVSG&#41; versus laparoscopic Roux-en-Y gastric bypass &#40;LRYGB&#41; procedures&#58; A meta-analysis and systematic review of randomized controlled trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Osland"
                            1 => "R&#46;M&#46; Yunus"
                            2 => "S&#46; Khan"
                            3 => "B&#46; Memon"
                            4 => "M&#46;A&#46; Memon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/SLE.0000000000000374"
                      "Revista" => array:6 [
                        "tituloSerie" => "Surg Laparosc Endosc Percutan Tech"
                        "fecha" => "2017"
                        "volumen" => "27"
                        "paginaInicial" => "8"
                        "paginaFinal" => "18"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28145963"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of sleeve gastrectomy on type 2 diabetes as an alternative treatment modality to Roux-en-Y gastric bypass&#58; systemic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;-M&#46; Cho"
                            1 => "H&#46;J&#46; Kim"
                            2 => "E&#46; Lo Menzo"
                            3 => "S&#46; Park"
                            4 => "S&#46; Szomstein"
                            5 => "R&#46;J&#46; Rosenthal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.soard.2015.03.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Surg Obes Relat Dis"
                        "fecha" => "2015"
                        "volumen" => "11"
                        "paginaInicial" => "1273"
                        "paginaFinal" => "1280"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26071847"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Laparoscopic sleeve gastrectomy versus laparoscopic Roux-en-Y gastric bypass for morbid obesity and related comorbidities&#58; a meta-analysis of 21 studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Zhang"
                            1 => "J&#46; Wang"
                            2 => "W&#46; Ju"
                            3 => "Z&#46; Cao"
                            4 => "X&#46; Xu"
                            5 => "D&#46; Liu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11695-014-1385-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Obes Surg"
                        "fecha" => "2015"
                        "volumen" => "25"
                        "paginaInicial" => "19"
                        "paginaFinal" => "26"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25092167"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term and midterm outcomes of laparoscopic sleeve gastrectomy versus Roux-en-Y gastric bypass&#58; a systematic review and meta-analysis of comparative studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Shoar"
                            1 => "A&#46;A&#46; Saber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.soard.2016.08.011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Surg Obes Relat Dis"
                        "fecha" => "2017"
                        "volumen" => "13"
                        "paginaInicial" => "170"
                        "paginaFinal" => "180"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27720197"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S188558571730066X"
                          "estado" => "S300"
                          "issn" => "18855857"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Resolution of hyperlipidemia after laparoscopic Roux-en-Y gastric bypass"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "N&#46;T&#46; Nguyen"
                            1 => "E&#46; Varela"
                            2 => "A&#46; Sabio"
                            3 => "C&#46;-L&#46; Tran"
                            4 => "M&#46; Stamos"
                            5 => "S&#46;E&#46; Wilson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jamcollsurg.2006.03.019"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Coll Surg"
                        "fecha" => "2006"
                        "volumen" => "203"
                        "paginaInicial" => "24"
                        "paginaFinal" => "29"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16798484"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1521694212000022"
                          "estado" => "S300"
                          "issn" => "15216942"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cholesterol metabolism after bariatric surgery in grade 3 obesity&#58; differences between malabsorptive and restrictive procedures"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Benetti"
                            1 => "M&#46; Del Puppo"
                            2 => "A&#46; Crosignani"
                            3 => "A&#46; Veronelli"
                            4 => "E&#46; Masci"
                            5 => "F&#46; Frig&#232;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2337/dc12-1737"
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes Care"
                        "fecha" => "2013"
                        "volumen" => "36"
                        "paginaInicial" => "1443"
                        "paginaFinal" => "1447"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23275360"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Laparoscopic Roux-en-Y gastric bypass versus laparoscopic sleeve gastrectomy&#58; a case-control study and 3 years of follow-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46; Boza"
                            1 => "C&#46; Gamboa"
                            2 => "J&#46; Salinas"
                            3 => "P&#46; Achurra"
                            4 => "A&#46; Vega"
                            5 => "G&#46; P&#233;rez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.soard.2011.08.023"
                      "Revista" => array:6 [
                        "tituloSerie" => "Surg Obes Relat Dis"
                        "fecha" => "2012"
                        "volumen" => "8"
                        "paginaInicial" => "243"
                        "paginaFinal" => "249"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22285881"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Excess weight loss and cardiometabolic parameter reduction diminished among hispanics undergoing bariatric surgery&#58; outcomes in more than 2&#44;000 consecutive hispanic patients at a single institution"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "O&#46;K&#46; Serrano"
                            1 => "Y&#46; Zhang"
                            2 => "L&#46; Cumella"
                            3 => "E&#46; Kintzer"
                            4 => "N&#46; Ng"
                            5 => "E&#46; Sandoval"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jamcollsurg.2015.10.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Surg"
                        "fecha" => "2016"
                        "volumen" => "222"
                        "paginaInicial" => "166"
                        "paginaFinal" => "173"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26704717"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of restrictive &#40;sleeve gastrectomy&#41; vs hybrid bariatric surgery &#40;Roux-en-Y gastric bypass&#41; on lipid profile"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Benaiges"
                            1 => "J&#46;A&#46; Flores-Le-Roux"
                            2 => "J&#46; Pedro-Botet"
                            3 => "J&#46;M&#46; Ram&#243;n"
                            4 => "A&#46; Parri"
                            5 => "M&#46; Villatoro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11695-012-0662-8"
                      "Revista" => array:7 [
                        "tituloSerie" => "Obes Surg"
                        "fecha" => "2012"
                        "volumen" => "22"
                        "paginaInicial" => "1268"
                        "paginaFinal" => "1275"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22544352"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1885585717302049"
                          "estado" => "S300"
                          "issn" => "18855857"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evolution of glycolipid profile after sleeve gastrectomy vs&#46; Roux-en-Y gastric bypass&#58; results of a prospective randomized clinical trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Vix"
                            1 => "M&#46; Diana"
                            2 => "K&#46;-H&#46; Liu"
                            3 => "A&#46; D&#8217;Urso"
                            4 => "D&#46; Mutter"
                            5 => "H&#46;S&#46; Wu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11695-012-0827-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Obes Surg"
                        "fecha" => "2013"
                        "volumen" => "23"
                        "paginaInicial" => "613"
                        "paginaFinal" => "621"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23207829"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Laparoscopic Roux-en-Y gastric bypass vs&#46; laparoscopic sleeve gastrectomy for morbid obesity&#58; a systematic review and meta-analysis of lipid effects at one year post-surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Climent"
                            1 => "D&#46; Benaiges"
                            2 => "J&#46; Pedro-Botet"
                            3 => "A&#46; Goday"
                            4 => "I&#46; Sol&#224;"
                            5 => "J&#46;M&#46; Ram&#243;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.23736/S0391-1977.17.02627-X"
                      "Revista" => array:7 [
                        "tituloSerie" => "Minerva Endocrinol"
                        "fecha" => "2018"
                        "volumen" => "43"
                        "paginaInicial" => "87"
                        "paginaFinal" => "100"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28206728"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0167527316300092"
                          "estado" => "S300"
                          "issn" => "01675273"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Medium-term results of laparoscopic sleeve gastrectomy&#58; a matched comparison with gastric bypass"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "W&#46;-J&#46; Lee"
                            1 => "E&#46;-H&#46; Pok"
                            2 => "A&#46; Almulaifi"
                            3 => "J&#46;J&#46; Tsou"
                            4 => "K&#46;-H&#46; Ser"
                            5 => "Y&#46;-C&#46; Lee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Obes Surg"
                        "fecha" => "2015"
                        "volumen" => "25"
                        "paginaInicial" => "1431"
                        "paginaFinal" => "1438"
                        "itemHostRev" => array:3 [
                          "pii" => "S1885585713002880"
                          "estado" => "S300"
                          "issn" => "18855857"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bariatric surgery versus intensive medical therapy for diabetes-5-year outcomes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;R&#46; Schauer"
                            1 => "D&#46;L&#46; Bhatt"
                            2 => "J&#46;P&#46; Kirwan"
                            3 => "K&#46; Wolski"
                            4 => "A&#46; Aminian"
                            5 => "S&#46;A&#46; Brethauer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa1600869"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2017"
                        "volumen" => "376"
                        "paginaInicial" => "641"
                        "paginaFinal" => "651"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28199805"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A randomized clinical trial of laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy for the treatment of morbid obesity in China&#58; a 5-year outcome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Zhang"
                            1 => "H&#46; Zhao"
                            2 => "Z&#46; Cao"
                            3 => "X&#46; Sun"
                            4 => "C&#46; Zhang"
                            5 => "W&#46; Cai"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11695-014-1258-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Obes Surg"
                        "fecha" => "2014"
                        "volumen" => "24"
                        "paginaInicial" => "1617"
                        "paginaFinal" => "1624"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24827405"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of laparoscopic sleeve gastrectomy vs laparoscopic Roux-en-Y gastric bypass on weight loss at 5 years among patients with morbid obesity&#58; the SLEEVEPASS randomized clinical trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Salminen"
                            1 => "M&#46; Helmi&#246;"
                            2 => "J&#46; Ovaska"
                            3 => "A&#46; Juuti"
                            4 => "M&#46; Leivonen"
                            5 => "P&#46; Peromaa-Haavisto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.2017.20313"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2018"
                        "volumen" => "319"
                        "paginaInicial" => "241"
                        "paginaFinal" => "254"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29340676"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of laparoscopic sleeve gastrectomy vs laparoscopic Roux-en-Y gastric bypass on weight loss in patients with morbid obesity&#58; the SM-BOSS randomized clinical trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Peterli"
                            1 => "B&#46;K&#46; W&#246;lnerhanssen"
                            2 => "T&#46; Peters"
                            3 => "D&#46; Vetter"
                            4 => "D&#46; Kr&#246;ll"
                            5 => "Y&#46; B&#243;rbely"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.2017.20897"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2018"
                        "volumen" => "319"
                        "paginaInicial" => "255"
                        "paginaFinal" => "265"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29340679"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Changes in the lipid profile 5 years after bariatric surgery&#58; Laparoscopic Roux-en-Y gastric bypass versus laparoscopic sleeve gastrectomy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E&#46; Climent"
                            1 => "D&#46; Benaiges"
                            2 => "A&#46; Flores-Le Roux Juana"
                            3 => "M&#46; Ram&#243;n Jose"
                            4 => "J&#46; Pedro-Botet"
                            5 => "A&#46; Goday"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.soard.2018.05.006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Surg Obes Relat Dis"
                        "fecha" => "2018"
                        "volumen" => "14"
                        "paginaInicial" => "1099"
                        "paginaFinal" => "1105"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29941302"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/25299123/0000003200000002/v1_202003210823/S2529912320300188/v1_202003210823/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "66561"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Reviews"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/25299123/0000003200000002/v1_202003210823/S2529912320300188/v1_202003210823/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529912320300188?idApp=UINPBA00004N"
]
Article information
ISSN: 25299123
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 4 1 5
2024 October 23 5 28
2024 September 49 9 58
2024 August 43 11 54
2024 July 17 8 25
2024 June 23 9 32
2024 May 30 5 35
2024 April 41 12 53
2024 March 44 7 51
2024 February 84 10 94
2024 January 72 9 81
2023 December 64 3 67
2023 November 38 6 44
2023 October 47 3 50
2023 September 35 1 36
2023 August 34 5 39
2023 July 53 3 56
2023 June 48 3 51
2023 May 53 4 57
2023 April 45 2 47
2023 March 53 4 57
2023 February 44 6 50
2023 January 22 4 26
2022 December 21 4 25
2022 November 20 4 24
2022 October 18 9 27
2022 September 14 9 23
2022 August 21 8 29
2022 July 7 5 12
2022 June 8 5 13
2022 May 12 8 20
2022 April 11 7 18
2022 March 20 5 25
2022 February 10 3 13
Show all

Follow this link to access the full text of the article

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos