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Inicio Clínica e Investigación en Ginecología y Obstetricia Influencia de la edad gestacional en la contractilidad de los vasos coriónicos ...
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Vol. 29. Issue 7.
Pages 240-244 (January 2002)
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Vol. 29. Issue 7.
Pages 240-244 (January 2002)
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Influencia de la edad gestacional en la contractilidad de los vasos coriónicos humanos in vitro
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A. Abadb, L. Estaña, F.J. Morales Olivasa, V. Serrab
a Departamento de Farmacología. Facultad de Medicina. Universidad de Valencia. Valencia. España
b Departamento de Pediatría, Obstetricia y Ginecología. Universidad de Valencia. Valencia. España
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Resumen

Los vásos placentarios humanos carecen de inervación autónoma y, por lo tanto, la resistencia vascular debe ser controlada por factores humorales y mecanismos anteriores autocrinos o paracrinos.

Estos factores pueden variar en las diferentes etapas de la gestación; asimismo, la respuesta de los vasos placentarios puede ser diferente según la edad gestacional. Se conocen diversas sustancias que, originadas en el feto, la madre o el cordón umbilical, pueden afectar al tono vascular fetoplacentario de forma directa o indirecta.

Investigamos si la edad gestacional modifica la respuesta vascular in vitrode los vasos placentarios a unagente vasoconstrictor como el cloruro potásico (ClK).

Summary

Human placentary vessels lack autonomic nervous system, and thus vascular resistance must be controlled by humoral factors and also autocrine and para-crine mechanisms.

These factors may vary at different stages of pregnancy, thus, the response of the placentary vessels may be different depending on gestational age. Various substances originating in the foetus, the mother or the umbilical cord are known, which may affect the foetal-placentary tone in a direct or indirect manner.

We investigate if it is gestational age which modifies in vitro response of the placentary vessels, or a vasoconstrictor such as potassium chloride.

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Copyright © 2002. Elsevier España, S.L.. Todos los derechos reservados
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