Tratamiento del hirsutismo con flutamida a dosis de 250 mg/día: estudio clínico prospectivo a un año | Clínica e Investigación en Ginecología y Obstetricia

Article information

Resumen

Se estudia a 27 mujeres afectadas de hirsutismo durante un año, con tratamiento de flutamida, 250 mg/día. Se analiza la puntuación de FerrimanGallway antes del tratamiento y al cabo de un año. Se valoran también antes del tratamiento y al cabo de unaño las determinaciones hormonales y los análisis generales.

Los resultados fueron mejoría clínica en 21 casos (81,48%). Dos casos (7,40%) abandonaron el tratamiento y otros dos no mejoraron(7,40%).

La puntuación de FerrimanGallway pasó de 17,74 a 9,33, muy significativa, p < 0,001.

Los efectos secundarios, corregidos, ocurrieron en 6 casos (22,22%), y no hubo toxicidad hepática. No existieron diferencias en las transaminasas.

Como conclusión, la flutamida es efectiva en el tratamiento del hirsutismo, y es mejor tolerada a dosis bajas.

Summary

We studied 27 women with hirsutism, treated for one year with a daily dose of 250 mg flutamide. The Ferriman-Gallway score was measured before and at the end of the treatment year. Hormonal levels and general analysis were also measured before and at one year.

The results were: clinical improvement in 21 cases (81.48%). Two patients abandoned treatment (7.40%), and 2 patients did not improve (7.40%).

The Ferriman-Gallway score improved, changing from 17.74 to 9.33, p < 0.001, which was significant. Side-effects, were found in 6 cases (22.2%), there was no hepatotoxicity. No differences were found in the transaminases.

We conclude that flutamide is effective in the treatment of hirsutism, and well tolerated at lower doses.

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