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class="elsevierStyleItalic">versus</span> 6 hours" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig5" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 1234 "Ancho" => 2004 "Tamanyo" => 131140 ] ] "descripcion" => array:1 [ "en" => "<p id="spara50" class="elsevierStyleSimplePara elsevierViewall">Association between the two interventions and residual gastric volume (mL), logarithm of residual gastric volume (mL), and pH for patients with hypothyroidism.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Renzo Feitosa Ruiz, Jose Jukemura, Paulo Roberto Arruda Alves, Marcos Eduardo Lera dos Santos" 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remission rates of irritable bowel syndrome: a controlled clinical trial meta-analysis" "tieneTextoCompleto" => true "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Yan Xiong, Lulu Liu, Xuchun Zhou, Youfei Wen, Ruonan Wang" "autores" => array:5 [ 0 => array:3 [ "nombre" => "Yan" "apellidos" => "Xiong" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] ] ] 1 => array:3 [ "nombre" => "Lulu" "apellidos" => "Liu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] ] ] 2 => array:4 [ "nombre" => "Xuchun" "apellidos" => "Zhou" "email" => array:1 [ 0 => "chqxchzh@163.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] 3 => array:3 [ "nombre" => "Youfei" "apellidos" => "Wen" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "Ruonan" "apellidos" => "Wang" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">II</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Department of Gastroenterology, the First Affiliated Hospital of Chongqing Medical University, People's Republic of China" "etiqueta" => "I" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Hainan Medical College, People's Republic of China" "etiqueta" => "II" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1346 "Ancho" => 653 "Tamanyo" => 135018 ] ] "descripcion" => array:1 [ "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Risk-of-bias summary.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">Irritable bowel syndrome (IBS) is a functional gastrointestinal disease with variable incidence rate in countries across the globe. Incomplete statistics suggest that the worldwide incidence of IBS ranges from 7% to 15% with this increasing to as much as 20% in some populations in China (<a class="elsevierStyleCrossRef" href="#bib1">1</a>). IBS is characterized by recurrent abdominal pain and changes in bowel movements. Its influence on the quality of life cannot be ignored but clinical interventions remain largely ineffective (<a class="elsevierStyleCrossRef" href="#bib2">2</a>). Studies have shown that IBS is a complex syndrome caused by long-term interactions between various psychosomatic factors, neuroendocrine factors, immunity, drugs, and infection, among others (<a class="elsevierStyleCrossRef" href="#bib3">3</a>,<a class="elsevierStyleCrossRef" href="#bib4">4</a>). <span class="elsevierStyleItalic">Helicobacter pylori</span>, an important gastroenterological pathogen has an infection rate of up to 50% in Chinese populations (<a class="elsevierStyleCrossRef" href="#bib5">5</a>), and has been linked to a variety of digestive tract diseases. However, the belief that the <span class="elsevierStyleItalic">H. pylori</span> infection rate in IBS patients is higher than that of the healthy population is still controversial. This study was designed to evaluate meta-data from several clinical studies to identify any evidence supporting the positive relationship between anti-<span class="elsevierStyleItalic">H. pylori</span> therapy and improved clinical remission rates for IBS.</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">MATERIAL AND METHODS</span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">Inclusion and exclusion criteria</span><p id="para20" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Inclusion criteria:</span> The following study criteria were used: (1) Study design: clinical controlled trial; (2) Study content: discussion of any differences in the effective remission rates of IBS patients with or without anti-<span class="elsevierStyleItalic">H. pylori</span> treatment; the specific sample size and effective remission rates for both the experimental and control groups must have been accurately recorded; (3) Study subjects: IBS patients who meet the Rome II, III, or IV diagnostic criteria and an <span class="elsevierStyleItalic">H. pylori-positive</span> result based on either a <span class="elsevierStyleSup">13</span>C, <span class="elsevierStyleSup">14</span>C urea breath test (UBT) or rapid urease test (RUT); (4) Study results: the strategy used for the evaluation of the effective remission rate for IBS must be similar between studies. Expected effect: abdominal pain, diarrhea, constipation, and other symptoms almost completely disappeared; Effective outcomes: abdominal pain, diarrhea, constipation and other symptoms are significantly reduced but still exist; Invalid: abdominal pain, diarrhea, constipation, and other symptoms were not reduced or patients experienced increased severity. Total effective rate = (number of obvious effect cases+number of effective cases)/number of total cases × 100%.</p></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle50">Exclusion criteria</span><p id="para30" class="elsevierStylePara elsevierViewall">The following exclusion criteria were used: (1) Non-clinical data or repeated publications including reviews and animal studies; (2) Unavailable text, incomplete data, lack of control group data or incalculable data; (3) Articles using previously published data.</p></span><span id="cesec50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle60">Retrieval strategies</span><p id="para40" class="elsevierStylePara elsevierViewall">PubMed, Embase, the Cochrane Central Register of Controlled Trials, CNKI, CBM, Wanfang and VIP databases were searched using various search terms, including “<span class="elsevierStyleItalic">helicobacter pylori</span>,” “<span class="elsevierStyleItalic">H. pylori</span>,” “<span class="elsevierStyleItalic">Campylobacter pylori</span>,” “irritable bowel syndrome,” “Irritable Bowel Syndromes,” “Syndrome, Irritable Bowel,” “Syndromes, Irritable Bowel,” “Colon, Irritable,” “Irritable Colon,” “Colitis, Mucous,” “Colitides, Mucous," “Mucous Colitides,” and “Mucous Colitis.” PubMed database retrieval strategy: ((((((((((((Irritable Bowel Syndromes[Title/Abstract]) OR Syndrome, Irritable Bowel[Title/Abstract]) OR Syndromes, Irritable Bowel[Title/Abstract]) OR Colon, Irritable[Title/Abstract]) OR Irritable Colon[Title/Abstract]) OR Colitis, Mucous[Title/Abstract]) OR Colitides, Mucous[Title/Abstract]) OR Mucous Colitides[Title/Abstract]) OR Mucous Colitis[Title/Abstract])) OR irritable bowel syndrome[Mesh])) AND ((((Campylobacter pylori[Title/Abstract]) OR H.pylori[Title/Abstract])) OR helicobacter pylori[Mesh]). The search results were reviewed independently by two researchers and were evaluated by a third person if there were any objections or doubts. The search period covered nearly 15 years and ended in September 2019.</p></span><span id="cesec60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">Data extraction</span><p id="para50" class="elsevierStylePara elsevierViewall">In total, 170 studies from various databases were initially identified, and 90 of these were then excluded as duplicates. After screening the titles and abstracts of the remaining 80 studies, 64 were excluded as they included non-clinical data, or there was no access to the full text. The full texts of the remaining studies were then screened resulting in the exclusion of an additional six studies that did not provide any data on the association between anti-<span class="elsevierStyleItalic">H. pylori</span> treatment and IBS clinical remission rates or because they were systematic reviews/meta-analyses. This left us with ten studies (<a class="elsevierStyleCrossRefs" href="#bib6">6–15</a>) that were eligible for meta-analysis, this criteria is summarized in <a class="elsevierStyleCrossRef" href="#fig1">Fig. 1</a>. We extracted the first author's name, year of publication, IBS Rome diagnostic criteria, diagnostic criteria for <span class="elsevierStyleItalic">H. pylori</span> infection, the number of patients in the experimental and control groups, and the effective clinical remission rate for each group. These data are summarized in <a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>.</p><elsevierMultimedia ident="fig1"></elsevierMultimedia><elsevierMultimedia ident="tbl1"></elsevierMultimedia></span><span id="cesec70" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">Quality evaluation and Risk-of-bias assessments</span><p id="para60" class="elsevierStylePara elsevierViewall">The Newcastle-Ottawa Scale (NOS) was used to evaluate the data quality in all ten of the included studies, all ten studies showed a score ≥6 points (<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>). At the same time, two researchers (YX, LL) independently evaluated the quality of the included studies using the Cochrane risk-of-bias criteria. Every quality item was classified into unclear risk, low risk, or high risk. Any disagreements were resolved through discussion or consultation between the two independent researchers, and seven criteria were used to assess bias. <a class="elsevierStyleCrossRef" href="#fig2">Figure 2</a> summarizes the quality of the included literature and showed that all ten studies are relatively reliable.</p><elsevierMultimedia ident="fig2"></elsevierMultimedia></span><span id="cesec80" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">Statistical analysis</span><p id="para70" class="elsevierStylePara elsevierViewall">RevMan 5.3.5 and Stata 15.1 software were used to perform the meta-analysis. First, the I<span class="elsevierStyleSup">2</span> test was used to evaluate the heterogeneity between the studies. I<span class="elsevierStyleSup">2</span>>50% indicated that the studies were significantly different, and I<span class="elsevierStyleSup">2</span><50% indicated less heterogeneity. Second, a random-effects model was used to pool the odds ratios (ORs) for each evaluation using a 95% confidence interval (CIs). The combined OR values and 95% CIs were calculated and visualized using a Forrest plot. If <span class="elsevierStyleItalic">p</span><0.05, the difference was considered significant. Then a funnel plot was used to calculate the insecurity factor, and the publication bias was quantitatively evaluated using RevMan 5.3.5 and Stata 15.1 software. Finally, the stability of the evaluation results was evaluated using a sensitivity analysis.</p></span></span><span id="cesec90" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle100">RESULTS</span><span id="cesec100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle110">Combined effect analysis</span><p id="para80" class="elsevierStylePara elsevierViewall">A random-effects model was used to determine whether there was a significant difference in the effective remission rates for IBS patients with or without anti-<span class="elsevierStyleItalic">H. pylori</span> treatment. As shown in <a class="elsevierStyleCrossRef" href="#fig3">Figure 3</a>, the I<span class="elsevierStyleSup">2</span> value was 32% suggesting a low degree of heterogeneity. The combined OR was 2.87 (95% CI: 1.74-4.72), <span class="elsevierStyleItalic">p</span><0.0001, suggesting that anti-<span class="elsevierStyleItalic">H. pylori</span> treatment can effectively improve the clinical remission rates of IBS patients.</p><elsevierMultimedia ident="fig3"></elsevierMultimedia></span><span id="cesec110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle120">Publication bias analysis</span><p id="para90" class="elsevierStylePara elsevierViewall">The publication bias was roughly evaluated using a funnel plot analysis. The graphs on both sides of the funnel plot were symmetrical, suggesting that publication bias had little impact on the results. To plot the scatter plot, the OR value was used as the abscissa and the SE(log [OR]) value as the ordinate (<a class="elsevierStyleCrossRef" href="#fig4">Fig. 4</a>). The results showed that the effect value was relatively concentrated in the middle and upper parts of the graph, with a roughly symmetrical shape, indicating that publication bias was less likely to be the cause of any differences. The Begg's method was used to quantitatively evaluate publication bias (<a class="elsevierStyleCrossRef" href="#fig5">Fig. 5</a>), and produced a Z value of 1.25, Pr>∣Z∣=0.210>0.05, suggesting that there was no real publication bias in this study.</p><elsevierMultimedia ident="fig4"></elsevierMultimedia><elsevierMultimedia ident="fig5"></elsevierMultimedia></span><span id="cesec120" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle130">Sensitivity analysis</span><p id="para100" class="elsevierStylePara elsevierViewall">Sensitivity analysis was performed using a fixed-effects and random-effects model, which re-estimated the results by omitting one study to determine the effect of each individual study on the overall result (<a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>). This evaluation showed that the results of this study were relatively stable.</p><elsevierMultimedia ident="tbl2"></elsevierMultimedia></span></span><span id="cesec130" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle140">DISCUSSION</span><p id="para110" class="elsevierStylePara elsevierViewall">A total of ten studies were included in this review, and all ten evaluated the effective remission rates of the clinical symptoms (abdominal pain, diarrhea, constipation,) in IBS patients who were receiving anti-<span class="elsevierStyleItalic">H. pylori</span> treatment and those who were not. Seven studies demonstrated a positive effect and three reported a negative result. The findings of the meta-analysis showed that anti-<span class="elsevierStyleItalic">H. pylori</span> treatment could effectively improve the clinical remission rates of IBS patients.</p><p id="para120" class="elsevierStylePara elsevierViewall">As one of the most common pathogenic bacteria in the digestive system, <span class="elsevierStyleItalic">H. pylori</span> infections have been shown to be closely related with the development of chronic gastritis, gastric ulcers, and gastric cancer. Various antigens and toxins produced by <span class="elsevierStyleItalic">H. pylori</span> can cause cellular vacuolization, mitochondrial dysfunction, and endoplasmic reticulum-mediated stress, all of which lead to the generation of oxidative stress, which is recognized by the immune system and activates the transcriptional upregulation of pro-inflammatory cytokines and chemokines triggering a series of inflammatory responses (<a class="elsevierStyleCrossRef" href="#bib16">16</a>,<a class="elsevierStyleCrossRef" href="#bib17">17</a>). <span class="elsevierStyleItalic">H. pylori</span> can also activate the immune system via the brain-gut axis and via the regulation of gastrointestinal hormones, resulting in increased secretion of gastrin, cholecystokinin, and other gastrointestinal hormones, and increased activity of intestinal smooth muscle cells. This leads to a series of intestinal symptoms including diarrhea and abdominal pain (<a class="elsevierStyleCrossRef" href="#bib18">18</a>,<a class="elsevierStyleCrossRef" href="#bib19">19</a>). Several studies have shown that anti-<span class="elsevierStyleItalic">H. pylori</span> treatment can result in a change in intestinal flora often significantly decreasing the abundance of <span class="elsevierStyleItalic">Escherichia coli,</span> while increasing that of <span class="elsevierStyleItalic">Klebsiella</span> and other Enterobacteriaceae (<a class="elsevierStyleCrossRef" href="#bib20">20</a>,<a class="elsevierStyleCrossRef" href="#bib21">21</a>). But whether such changes aggravate or improve the clinical symptoms for IBS has not been evaluated.</p><p id="para130" class="elsevierStylePara elsevierViewall">IBS is a functional gastrointestinal disease with unclear pathogenesis. Some studies have shown that IBS patients may have low-grade inflammation and organ damage (<a class="elsevierStyleCrossRef" href="#bib22">22</a>,<a class="elsevierStyleCrossRef" href="#bib23">23</a>). Some animal studies have found that intestinal microecology imbalances and disordered intestinal flora can induce Kupffer cell proliferation and TNF-α and INF-γ expression, which may result in liver cell damage (<a class="elsevierStyleCrossRef" href="#bib24">24</a>,<a class="elsevierStyleCrossRef" href="#bib25">25</a>).</p><p id="para140" class="elsevierStylePara elsevierViewall">Studies have confirmed that the occurrence of IBS can be linked to increased activation of the gut-brain axis, high visceral sensitivity, intestinal flora changes, and increased immune activation. It is worth noting that intestinal flora changes may vary between regions and these changes are primarily characterized by significant decreases in <span class="elsevierStyleItalic">Bifidobacterium</span> and <span class="elsevierStyleItalic">Lactobacillus</span> in Chinese patients and a decrease in <span class="elsevierStyleItalic">Bifidobacteria</span> and an increase in <span class="elsevierStyleItalic">Bacteroides</span> in European patients (<a class="elsevierStyleCrossRef" href="#bib26">26</a>,<a class="elsevierStyleCrossRef" href="#bib27">27</a>). Small intestine bacterial overgrowth (SIBO) is a condition characterized by the translocation of the distal intestinal flora to the small intestine in response to a variety of factors; this results in the overgrowth of anaerobic bacteria, which is responsible for the manifestation of a series of clinical symptoms. Because of the overlap in clinical symptoms between SIBO and IBS, SIBO is currently under investigation as one of the potential pathogenic routes to IBS. In the meta-analysis, more than one-third of the IBS patients were found to be positive for SIBO; this is a significantly higher incidence than that observed in healthy individuals. Female sex, higher age, and IBS-induced diarrhea were all associated with SIBO in individuals with IBS (<a class="elsevierStyleCrossRef" href="#bib28">28</a>). SIBO can alter the intestinal microenvironment by altering the inflammatory responses, regulating the immune system, intestinal mucosal permeability, and gas production, thereby validating the partial overlap between SIBO and IBS. Our study also demonstrated that antibiotic therapy can partially alleviate the clinical manifestations of IBS; this finding is in agreement with other literature, which suggests that antibiotic therapy can significantly improve the clinical symptoms of IBS patients with SIBO (<a class="elsevierStyleCrossRefs" href="#bib29">29–31</a>). In addition, several papers have demonstrated a link between SIBO and <span class="elsevierStyleItalic">H. pylori</span> infection. Patients with <span class="elsevierStyleItalic">H. pylori</span> are more likely to test positive for SIBO (<a class="elsevierStyleCrossRef" href="#bib32">32</a>). Further, <span class="elsevierStyleItalic">H. pylori</span> eradication therapy can effectively relieve the clinical symptoms of patients with SIBO (<a class="elsevierStyleCrossRef" href="#bib33">33</a>), which also suggests there is some correlation between <span class="elsevierStyleItalic">H. pylori</span> infection, and SIBO and IBS. Anti-<span class="elsevierStyleItalic">H. pylori</span> treatment may relieve the clinical symptoms of IBS by ameliorating SIBO. However, this aspect was not included in the original studies, suggesting a need for additional studies that use bacterial culture to objectively demonstrate these interactions. The intestinal mucosal immune system of IBS patients is characterized by a significant increase in the levels of lymphocytes (T cells) and mast cells, resulting in an increased release of trypsin and histamine leading to abdominal pain (<a class="elsevierStyleCrossRef" href="#bib34">34</a>,<a class="elsevierStyleCrossRef" href="#bib35">35</a>). Colon biopsies of post-infection IBS patients show that intestinal endocrine cells (ECs) increase more than five times in number, while lamina propria T cells (CD3, CD4 and CD8) double in number. Meanwhile, resident macrophage (CD68) populations are reduced by half and activated macrophage populations increase significantly. Activated macrophages produce many pro-inflammatory cytokines, including IL-1, which further stimulate intestinal ECs to produce excessive 5-HT, which may activate 5-HT mediated vagal afferent nuclei and increase the sensitivity of the emotional and autonomic neural networks in the brain. The vagus nerve is an important part of the microbiome-gut-brain axis that conveys the sensory and microbial information from the gut to the brain. The activation of inflammatory cells, the increase in pro-inflammatory factors, and the activation of the vagus nerve can lead to the development of diarrhea and visceral hypersensitivity (<a class="elsevierStyleCrossRef" href="#bib36">36</a>). All these factors can affect the nature and duration of intestinal inflammation. Different individuals need different recovery times to restore their original balance, and eventually, some people will develop IBS (<a class="elsevierStyleCrossRef" href="#bib37">37</a>,<a class="elsevierStyleCrossRef" href="#bib38">38</a>).</p><p id="para150" class="elsevierStylePara elsevierViewall">Current studies suggest that IBS may be associated with <span class="elsevierStyleItalic">H. pylori</span> infection (<a class="elsevierStyleCrossRef" href="#bib39">39</a>,<a class="elsevierStyleCrossRef" href="#bib40">40</a>). A meta-analysis by L MR et al. (<a class="elsevierStyleCrossRef" href="#bib41">41</a>) suggested that <span class="elsevierStyleItalic">H. pylori</span> infection rates in IBS patients were significantly higher than expected in a healthy population. However, a similar meta-analysis by Ng et al. (<a class="elsevierStyleCrossRef" href="#bib42">42</a>) showed that there was no clear evidence to support an association between IBS and <span class="elsevierStyleItalic">H. pylori</span>; however this may be attributed to the smaller sample size in this study. Our results suggest that anti-<span class="elsevierStyleItalic">H. pylori</span> treatment could reduce IBS symptoms, and this may be mediated by the effects of anti-<span class="elsevierStyleItalic">H. pylori</span> treatments on gastrointestinal pH and flora changes, thereby promoting the recovery of the intestinal mucosal immune system and the gut-brain axis and restoring the regulation of the gastrointestinal hormone system (<a class="elsevierStyleCrossRef" href="#bib32">32</a>). The specific mechanism underlying these effects is not yet clear, and further experiments are needed.</p><p id="para160" class="elsevierStylePara elsevierViewall">A key limitation of this is study the subjective outcome evaluation of the included literature, which fails to specify the detailed amelioration of clinical symptoms, such as abdominal pain, diarrhea, and constipation. Therefore, more accurate scales need to be used to effectively quantify the clinical outcomes. The development of these tools would facilitate stronger evidence-based conclusions in the future. It is necessary to point out the fact that the lack of <span class="elsevierStyleItalic">H. pylori</span> eradication in the experimental group is not the result of ineffective anti-<span class="elsevierStyleItalic">H. pylori</span> treatment but rather owing to the fact that the treatment was aimed at preventing infection instead of eradicating the bacteria. This qualification should be more apparent in clinical trials and the effect of a preventative treatment should be evaluated in additional clinical trials. In addition, because of the limited sample size, the clinical remission rate could not be compared between different subgroups of IBS, suggesting that these findings should be validated in larger populations.</p></span><span id="cesec140" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle150">AUTHOR CONTRIBUTIONS</span><p id="para170" class="elsevierStylePara elsevierViewall">Xiong Y, Zhou X contributed to study design. Xiong Y contributed in literature search, analysys and draft writing. Xiong Y, Liu L, Zhou X, Wang R, Wen Y contributed in literature screening. Xion Y, Liu L, Zhou X contributed in data extraction</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:2 [ "identificador" => "xpalclavsec1580129" "titulo" => "KEYWORDS" ] 1 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 2 => array:3 [ "identificador" => "cesec20" "titulo" => "MATERIAL AND METHODS" "secciones" => array:6 [ 0 => array:2 [ "identificador" => "cesec30" "titulo" => "Inclusion and exclusion criteria" ] 1 => array:2 [ "identificador" => "cesec40" "titulo" => "Exclusion criteria" ] 2 => array:2 [ "identificador" => "cesec50" "titulo" => "Retrieval strategies" ] 3 => array:2 [ "identificador" => "cesec60" "titulo" => "Data extraction" ] 4 => array:2 [ "identificador" => "cesec70" "titulo" => "Quality evaluation and Risk-of-bias assessments" ] 5 => array:2 [ "identificador" => "cesec80" "titulo" => "Statistical analysis" ] ] ] 3 => array:3 [ "identificador" => "cesec90" "titulo" => "RESULTS" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "cesec100" "titulo" => "Combined effect analysis" ] 1 => array:2 [ "identificador" => "cesec110" "titulo" => "Publication bias analysis" ] 2 => array:2 [ "identificador" => "cesec120" "titulo" => "Sensitivity analysis" ] ] ] 4 => array:2 [ "identificador" => "cesec130" "titulo" => "DISCUSSION" ] 5 => array:2 [ "identificador" => "cesec140" "titulo" => "AUTHOR CONTRIBUTIONS" ] 6 => array:2 [ "identificador" => "xack638123" "titulo" => "ACKNOWLEDGMENTS" ] 7 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-03-31" "fechaAceptado" => "2020-07-10" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1580129" "palabras" => array:4 [ 0 => "Irritable Bowel Syndrome" 1 => "<span class="elsevierStyleItalic">Helicobacter Pylori</span> Infection" 2 => "IBS treatment" 3 => "Meta-analysis" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:1 [ "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><p id="spara80" class="elsevierStyleSimplePara elsevierViewall">Here we used a meta-analysis of several clinical trials to determine whether anti-<span class="elsevierStyleItalic">Helicobacter pylori</span> therapy has any positive effect on IBS patients. Here we compared the effective clinical remission rates between IBS patients treated with anti-<span class="elsevierStyleItalic">H. pylori</span> therapy and those who were not. This data would provide more clinical evidence regarding the efficacy of novel treatments and intervention points for IBS patients.</p><p id="spara90" class="elsevierStyleSimplePara elsevierViewall">Relevant studies were identified using keyword searches on various electronic databases, including PubMed, Embase, the Cochrane Central Register of Controlled Trials, CNKI, and CBM. Keywords included “<span class="elsevierStyleItalic">helicobacter pylori</span>” and “irritable bowel syndrome” among others. The literature was screened using relatively strict inclusion and exclusion criteria and RevMan 5.3.5 and Stata 15.1 software were used for meta-analysis and to assess publication bias and sensitivity.</p><p id="spara100" class="elsevierStyleSimplePara elsevierViewall">A total of ten studies met all of the inclusion criteria; these included 655 IBS patients with <span class="elsevierStyleItalic">H. pylori</span> infection, of these, 385 patients were in the experimental group and 270 patients were in the control group. A random-effects model was used to pool the odds ratios (ORs) with a 95% confidence interval (CIs) and the combined OR was 2.87 (95% CI: 1.74-4.72), <span class="elsevierStyleItalic">p</span><0.0001. These findings suggest that anti-<span class="elsevierStyleItalic">H. pylori</span> therapy can effectively improve the remission rates of <span class="elsevierStyleItalic">H. pylori-</span>positive IBS patients.</p><p id="spara110" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">H. pylori</span> infection is known to correlate with the incidence of IBS. Anti-<span class="elsevierStyleItalic">H. pylori</span> treatment can effectively improve the clinical remission rates of IBS patients. Whether this means that IBS patients should be actively treated with anti-<span class="elsevierStyleItalic">H. pylori</span> compounds as a novel strategy to improve the remission rates needs to be evaluated <span class="elsevierStyleItalic">in vivo</span>.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara" id="cenpara10">Errata</p> <p class="elsevierStyleNotepara" id="cenpara20">CLINICS 2021;76:e1857err</p> <p class="elsevierStyleNotepara" id="cenpara30">Erratum for: doi: <span class="elsevierStyleInterRef" id="interrefs10" href="https://doi.org/10.6061/clinics/2020/e1857">https://doi.org/10.6061/clinics/2020/e1857</span>, published in 2020.</p> <p class="elsevierStyleNotepara" id="cenpara40">Replace the corresponding author: Yan Xiong</p> <p class="elsevierStyleNotepara" id="cenpara50">For: Xuchun Zhou*</p> <p class="elsevierStyleNotepara" id="cenpara60">No potential conflict of interest was reported.</p>" ] ] "multimedia" => array:7 [ 0 => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1194 "Ancho" => 1253 "Tamanyo" => 86072 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Flow chart depicting data selection and inclusion criteria used.</p>" ] ] 1 => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1346 "Ancho" => 653 "Tamanyo" => 135018 ] ] "descripcion" => array:1 [ "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Risk-of-bias summary.</p>" ] ] 2 => array:7 [ "identificador" => "fig3" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 600 "Ancho" => 1753 "Tamanyo" => 117159 ] ] "descripcion" => array:1 [ "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Forest plot.</p>" ] ] 3 => array:7 [ "identificador" => "fig4" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 634 "Ancho" => 977 "Tamanyo" => 19851 ] ] "descripcion" => array:1 [ "en" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">Funnel plot.</p>" ] ] 4 => array:7 [ "identificador" => "fig5" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 616 "Ancho" => 976 "Tamanyo" => 32329 ] ] "descripcion" => array:1 [ "en" => "<p id="spara50" class="elsevierStyleSimplePara elsevierViewall">Begg's funnel plot.</p>" ] ] 5 => array:7 [ "identificador" => "tbl1" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="5" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">IBS patients with Hp infection</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Year \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Author \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">IBS Diagnostic criteria \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Hp detection method \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Number in experimental groups \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Number in control group \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">The number of cases effectively alleviated in the experimental group \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Number of cases of effective remission in the control group \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Statistical significance \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">NOS \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2016 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Xiong F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Rome III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">UBT+RUT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">54 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2006 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yu DH \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Rome II \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">UBT+RUT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">no \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2015 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lu SM \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Rome III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">UBT+RUT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2018 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Qu TS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Rome III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">UBT+RUT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">41 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">37 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Shi J \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Rome III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">UBT+RUT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">no \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Li XQ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Rome III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">UBT+RUT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2019 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yang LQ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Rome IV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">UBT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">84 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">49 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2017 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yang Y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Rome III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">UBT+RUT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">no \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2011 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yuan ZP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Rome III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">UBT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2010 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Han H \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Rome III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">UBT+RUT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara60" class="elsevierStyleSimplePara elsevierViewall">Basic information describing the studies included in the meta-analysis.</p>" ] ] 6 => array:7 [ "identificador" => "tbl2" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Sensitivity analysis \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Number of articles \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Z value \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"><span class="elsevierStyleItalic">p</span>-value \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">OR value(95%CI) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Random-effects model \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.0001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.87 (1.74,4.72) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fixed-effects model \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.00001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.86 (1.95,4.20) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Random-effects model without the XIONG et al. study \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.00001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.29 (1.97,5.49) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fixed-effects model without the XIONG et al. study \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.00001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.37 (2.19,5.17) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara70" class="elsevierStyleSimplePara elsevierViewall">Sensitivity analysis.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:42 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of epidemiological investigation of irritable bowel syndrome in China" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ XQ Li \n \t\t\t\t\t\t\t\t """ 1 => """ M Chang \n \t\t\t\t\t\t\t\t """ 2 => """ D Xu \n \t\t\t\t\t\t\t\t """ 3 => """ XC Fang \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Chin J Gastroenterol Hepatol" "fecha" => "2013" "volumen" => "22" "numero" => "8" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2013&filename=WCBX201308007&v=PbadWf99Cc9WJtIJvcda35t5%25mmd2FpITkglBr2UKIBXg9QfMhqI1kfiN98qNnkNe0V7A" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Irritable bowel syndrome: the clinical approach" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ A Adriani \n \t\t\t\t\t\t\t\t """ 1 => """ DG Ribaldone \n \t\t\t\t\t\t\t\t """ 2 => """ M Astegiano \n \t\t\t\t\t\t\t\t """ 3 => """ M Durazzo \n \t\t\t\t\t\t\t\t """ 4 => """ GM Saracco \n \t\t\t\t\t\t\t\t """ 5 => """ R Pellicano \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.23736/S0031-0808.18.03541-3" "Revista" => array:7 [ "tituloSerie" => "Panminerva Med" "fecha" => "2018" "volumen" => "60" "numero" => "4" "paginaInicial" => "213" "paginaFinal" => "222" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30257542" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.23736/S0031-0808.18.03541-3" "WWW" => array:1 [ "link" => "https://doi.org/10.23736/S0031-0808.18.03541-3" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Functional gastrointestinal disorders: History, pathophysiology, clinical features and Rome IV" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ DA Drossman \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Gastroenterology" "fecha" => "2016" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of inflammation in irritable bowel syndrome (IBS)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ QX Ng \n \t\t\t\t\t\t\t\t """ 1 => """ AYS Soh \n \t\t\t\t\t\t\t\t """ 2 => """ W Loke \n \t\t\t\t\t\t\t\t """ 3 => """ DY Lim \n \t\t\t\t\t\t\t\t """ 4 => """ WS Yeo \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.2147/JIR.S174982" "Revista" => array:6 [ "tituloSerie" => "J Inflamm Res" "fecha" => "2018" "volumen" => "11" "paginaInicial" => "345" "paginaFinal" => "349" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30288077" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.2147/JIR.S174982" "WWW" => array:1 [ "link" => "https://doi.org/10.2147/JIR.S174982" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fifth Chinese National Consensus Report on the management of Helicobacter pylori infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ WZ Liu \n \t\t\t\t\t\t\t\t """ 1 => """ Y Xie \n \t\t\t\t\t\t\t\t """ 2 => """ H Lu \n \t\t\t\t\t\t\t\t """ 3 => """ H Cheng \n \t\t\t\t\t\t\t\t """ 4 => """ ZR Zeng \n \t\t\t\t\t\t\t\t """ 5 => """ LY Zhou \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Helicobacter" "fecha" => "2018" "volumen" => "23" "numero" => "2" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1111/hel.12475" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lack of Association Found between Helicobacter pylori Infection and Diarrhea-Predominant Irritable Bowel Syndrome: A Multicenter Retrospective Study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ F Xiong \n \t\t\t\t\t\t\t\t """ 1 => """ M Xiong \n \t\t\t\t\t\t\t\t """ 2 => """ Z Ma \n \t\t\t\t\t\t\t\t """ 3 => """ S Huang \n \t\t\t\t\t\t\t\t """ 4 => """ A Li \n \t\t\t\t\t\t\t\t """ 5 => """ S Liu \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Gastroenterol Res Pract" "fecha" => "2016" "volumen" => "2016" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1155/2016/3059201" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis on the Relationship between Irritable Bowel Syndrome,Its Subtypes and Helicobacter Pylori Infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ SM Lu \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Medical Recapitulate" "fecha" => "2015" "volumen" => "21" "numero" => "9" "paginaInicial" => "1695" "paginaFinal" => "1696" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2015&filename=YXZS201509064&v=sNhUYZFcDQ7E3iZ36UR4m%25mmd2B20UMK2B4JVJafolpj2Nc92whaKkoxM7y7mNzlxfam4" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The relationship between irritable bowel syndrome and helicobacter pylori infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ H Han \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Journal of practical medicine" "fecha" => "2010" "volumen" => "26" "numero" => "6" "paginaInicial" => "990" "paginaFinal" => "991" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2010&filename=SYYZ201006052&v=kDVk8mcUyhDYVqXmsAJ5%25mmd2F054xbD6K68ewYZzGUMS6GTN6O3Bh5r3VP90UGgzN9%25mmd2Fw" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Study about the Correlation of Irritable Bowel Syndrome and Helicobacter Pylori" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ DH Yu \n \t\t\t\t\t\t\t\t """ 1 => """ KD Li \n \t\t\t\t\t\t\t\t """ 2 => """ NF Gao \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JPMT" "fecha" => "2006" "volumen" => "13" "numero" => "4" "paginaInicial" => "0653" "paginaFinal" => "0655" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2006&filename=SYYJ200604147&v=BJwTM9pdB%25mmd2Bp%25mmd2BrPLKjNxZHXsSvUsd%25mmd2B%25mmd2BtoWWbMqitkmaYQFEPI8Y%25mmd2B0PKSZhHHpX1uP" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of Helicobacter pylori Eradication in Diarrhea-predominant Irritable Bowel Syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ Y Yang \n \t\t\t\t\t\t\t\t """ 1 => """ L Chen \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chin J Gastroenterol" "fecha" => "2017" "volumen" => "22" "numero" => "8" "paginaInicial" => "482" "paginaFinal" => "485" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The clinical effect of helicobacter pylori eradication in irritable bowel syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ ZP Yuan \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "CHINESE AND FOREIGN MEDICAL RESEARCH" "fecha" => "2011" "volumen" => "9" "numero" => "31" "paginaInicial" => "104" "paginaFinal" => "105" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2017&filename=WIEC201708009&v=vtwokdr7nX%25mmd2F7gKRywKZza0ofKLDNklD9EGfz%25mmd2FeTiy9sDZBy8xErEKZom80ndHsTi" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of berberine hydrochloride quadruple therapy on irritable bowel syndrome with diarrhea" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ LQ Yang \n \t\t\t\t\t\t\t\t """ 1 => """ PH Chen \n \t\t\t\t\t\t\t\t """ 2 => """ JL Li \n \t\t\t\t\t\t\t\t """ 3 => """ HY Liu \n \t\t\t\t\t\t\t\t """ 4 => """ SJ Zhou \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Shenzhen Journal of Integrated Traditional Chinese and Western Medicine" "fecha" => "2019" "volumen" => "29" "numero" => "10" "paginaInicial" => "0148" "paginaFinal" => "0149" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2011&filename=YJZY201131083&v=TKDTjcaIHGkx04u5wrzUQFfp0nb9QQxacHGotFOLF%25mmd2F5OSF1i1nPUcPZJqnCdud6C" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Influences of Helicobacter pylori infection on irritable bowel syndrome and its typing" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ TS Qu \n \t\t\t\t\t\t\t\t """ 1 => """ FC Wang \n \t\t\t\t\t\t\t\t """ 2 => """ YY Cai \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chinese Journal of Clinical Research" "fecha" => "2018" "volumen" => "31" "numero" => "5" "paginaInicial" => "0634" "paginaFinal" => "0636" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2019&filename=SZZX201910069&v=JKA74hKr1%25mmd2BdhaUikzC2WSdpQmRL2NGDaAMH9lJuypcZKqiUKWZgMu2ppRT6ykVz7" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The relationship between Helicobacter pylori infection and irritable bowel syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ XQ Li \n \t\t\t\t\t\t\t\t """ 1 => """ YS Wu \n \t\t\t\t\t\t\t\t """ 2 => """ LJ Pan \n \t\t\t\t\t\t\t\t """ 3 => """ ZQ Tan \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chin J Gastroenterol Hepatol" "fecha" => "2012" "volumen" => "21" "numero" => "8" "paginaInicial" => "0706" "paginaFinal" => "0707" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2018&filename=ZGCK201805015&v=QFDGGSgl424XKYbjqb1EUbdDQPSZ6Twq4gADnAaUVlQlrCKRugZXTlzRa%25mmd2FwEDgo3" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Study on the correlation between Helicobacter pylori infection and D-irritable bowel syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ J Shi \n \t\t\t\t\t\t\t\t """ 1 => """ XY Zhao \n \t\t\t\t\t\t\t\t """ 2 => """ X Jiao \n \t\t\t\t\t\t\t\t """ 3 => """ J Wang \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chinese General Practice" "fecha" => "2012" "volumen" => "15" "numero" => "6B" "paginaInicial" => "1912" "paginaFinal" => "1913" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2012&filename=WCBX201208008&v=kqxl%25mmd2FIyEuuU2Ia3ayuasage%25mmd2FYDdf72wZ1Jcp3blbeVVLMZ7ffqfqaLxJ7Hc%25mmd2BqlgO" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammasome activation and regulation during Helicobacter pylori pathogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ S Kumar \n \t\t\t\t\t\t\t\t """ 1 => """ M Dhiman \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "MicrobPatho" "fecha" => "2018" "volumen" => "125" "paginaInicial" => "468" "paginaFinal" => "474" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathogenesis and clinical management of Helicobacter pylori gastric infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => """ BB de Brito \n \t\t\t\t\t\t\t\t """ 1 => """ FAF da Silva \n \t\t\t\t\t\t\t\t """ 2 => """ AS Soares \n \t\t\t\t\t\t\t\t """ 3 => """ VA Pereira \n \t\t\t\t\t\t\t\t """ 4 => """ MLC Santos \n \t\t\t\t\t\t\t\t """ 5 => """ MM Sampaio \n \t\t\t\t\t\t\t\t """ 6 => """ PHM Neves \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.3748/wjg.v25.i37.5578" "Revista" => array:7 [ "tituloSerie" => "World J Gastroenterol" "fecha" => "2019" "volumen" => "25" "numero" => "37" "paginaInicial" => "5578" "paginaFinal" => "5589" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31602159" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.3748/wjg.v25.i37.5578" "WWW" => array:1 [ "link" => "https://doi.org/10.3748/wjg.v25.i37.5578" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Influence of Helicobacter pylori Infection on Gastrointestinal Hormone and Colon Motility of Rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ N Cui \n \t\t\t\t\t\t\t\t """ 1 => """ H Luo \n \t\t\t\t\t\t\t\t """ 2 => """ H Xia \n \t\t\t\t\t\t\t\t """ 3 => """ W Chen \n \t\t\t\t\t\t\t\t """ 4 => """ G Yu \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.amjms.2016.02.031" "Revista" => array:7 [ "tituloSerie" => "Am J Med Sci" "fecha" => "2016" "volumen" => "351" "numero" => "5" "paginaInicial" => "520" "paginaFinal" => "524" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27140712" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.amjms.2016.02.031" "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.amjms.2016.02.031" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brain-gut axis in the pathogenesis of Helicobacter pylori infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ J Budzyński \n \t\t\t\t\t\t\t\t """ 1 => """ M Kłopocka \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.3748/wjg.v20.i18.5212" "Revista" => array:7 [ "tituloSerie" => "World J Gastroenterol" "fecha" => "2014" "volumen" => "20" "numero" => "18" "paginaInicial" => "5212" "paginaFinal" => "5225" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24833851" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.3748/wjg.v20.i18.5212" "WWW" => array:1 [ "link" => "https://doi.org/10.3748/wjg.v20.i18.5212" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of Clostridium butyricum on fecal flora in Helicobacter pylori eradication therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ I Shimbo \n \t\t\t\t\t\t\t\t """ 1 => """ T Yamaguchi \n \t\t\t\t\t\t\t\t """ 2 => """ T Odaka \n \t\t\t\t\t\t\t\t """ 3 => """ K Nakajima \n \t\t\t\t\t\t\t\t """ 4 => """ A Koide \n \t\t\t\t\t\t\t\t """ 5 => """ H Koyama \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.3748/wjg.v11.i47.7520" "Revista" => array:7 [ "tituloSerie" => "World J Gastroenterol" "fecha" => "2005" "volumen" => "11" "numero" => "47" "paginaInicial" => "7520" "paginaFinal" => "7524" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16437727" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.3748/wjg.v11.i47.7520" "WWW" => array:1 [ "link" => "https://doi.org/10.3748/wjg.v11.i47.7520" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Influence of anti-Helicobacter triple-therapy with metronidazole, omeprazole and clarithromycin on intestinal microflora" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ A Bühling \n \t\t\t\t\t\t\t\t """ 1 => """ D Radun \n \t\t\t\t\t\t\t\t """ 2 => """ WA Müller \n \t\t\t\t\t\t\t\t """ 3 => """ P Malfertheiner \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1046/j.1365-2036.2001.01033.x" "Revista" => array:7 [ "tituloSerie" => "Aliment Pharmacol Ther" "fecha" => "2001" "volumen" => "15" "numero" => "9" "paginaInicial" => "1445" "paginaFinal" => "1452" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11552917" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1046/j.1365-2036.2001.01033.x" "WWW" => array:1 [ "link" => "https://doi.org/10.1046/j.1365-2036.2001.01033.x" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical Features and Expression of Cytokine in Post-infectious Irritable Bowel Syndrome Patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ YH D \n \t\t\t\t\t\t\t\t """ 1 => """ D LC, L \n \t\t\t\t\t\t\t\t """ 2 => """ YL P \n \t\t\t\t\t\t\t\t """ 3 => """ XC Z \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Journal of Sun Yat-sen University(Medical Sciences)" "fecha" => "2017" "volumen" => "38" "numero" => "2" "paginaInicial" => "260" "paginaFinal" => "266" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2012&filename=QKYX201217007&v=I01%25mmd2B0rVlDer1FZSV%25mmd2BvZHYZ1uMSD52B4DnpiyZ7cuqmiIKfCIWMOUonaukAxBRltS" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dynamic Changes of IL-17, occludin, and ZO-1 in Mice with Post-infectious Irritable Bowel Syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ YL Peng \n \t\t\t\t\t\t\t\t """ 1 => """ YH Dai \n \t\t\t\t\t\t\t\t """ 2 => """ Q He \n \t\t\t\t\t\t\t\t """ 3 => """ XC Zhou \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Journal of Sun Yat-sen University (Medical Sciences)" "fecha" => "2018" "volumen" => "39" "numero" => "3" "paginaInicial" => "341" "paginaFinal" => "348" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gastrointestinal symptoms - an illness burden that affects daily work in patients with IBS" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ Å Faresjö \n \t\t\t\t\t\t\t\t """ 1 => """ S Walter \n \t\t\t\t\t\t\t\t """ 2 => """ AK Norlin \n \t\t\t\t\t\t\t\t """ 3 => """ T Faresjö \n \t\t\t\t\t\t\t\t """ 4 => """ MP Jones \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1186/s12955-019-1174-1" "Revista" => array:6 [ "tituloSerie" => "Health Qual Life Outcomes" "fecha" => "2019" "volumen" => "17" "numero" => "1" "paginaInicial" => "113" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31262316" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1186/s12955-019-1174-1" "WWW" => array:1 [ "link" => "https://doi.org/10.1186/s12955-019-1174-1" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fecal Microbiota of Diarrhea-Predominant Irritable Bowel Syndrome Patients Causes Hepatic Inflammation of Germ-Free Rats and Berberine Reverses It Partially" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ Q Jia \n \t\t\t\t\t\t\t\t """ 1 => """ L Zhang \n \t\t\t\t\t\t\t\t """ 2 => """ J Zhang \n \t\t\t\t\t\t\t\t """ 3 => """ F Pei \n \t\t\t\t\t\t\t\t """ 4 => """ S Zhu \n \t\t\t\t\t\t\t\t """ 5 => """ Q Sun \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "BioMed Res Int" "fecha" => "2019" "volumen" => "2019" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "From the intestinal flora to the microbiome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ JJ Sebastián Domingo \n \t\t\t\t\t\t\t\t """ 1 => """ C Sánchez Sánchez \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.17235/reed.2017.4947/2017" "Revista" => array:7 [ "tituloSerie" => "REV ESP ENFERM DIG" "fecha" => "2018" "volumen" => "110" "numero" => "1" "paginaInicial" => "51" "paginaFinal" => "56" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29271225" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alterations of gut microbiota in patients with irritable bowel syndrome: A systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ X Zhuang \n \t\t\t\t\t\t\t\t """ 1 => """ L Xiong \n \t\t\t\t\t\t\t\t """ 2 => """ L Li \n \t\t\t\t\t\t\t\t """ 3 => """ M Li \n \t\t\t\t\t\t\t\t """ 4 => """ M Chen \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1111/jgh.13471" "Revista" => array:7 [ "tituloSerie" => "J Gastroenterol Hepatol" "fecha" => "2017" "volumen" => "32" "numero" => "1" "paginaInicial" => "28" "paginaFinal" => "38" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27300149" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1111/jgh.13471" "WWW" => array:1 [ "link" => "https://doi.org/10.1111/jgh.13471" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence and Predictors of Small Intestinal Bacterial Overgrowth in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ B Chen \n \t\t\t\t\t\t\t\t """ 1 => """ JJ Kim \n \t\t\t\t\t\t\t\t """ 2 => """ Y Zhang \n \t\t\t\t\t\t\t\t """ 3 => """ L Du \n \t\t\t\t\t\t\t\t """ 4 => """ N Dai \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1007/s00535-018-1476-9" "Revista" => array:7 [ "tituloSerie" => "J Gastroenterol" "fecha" => "2018" "volumen" => "53" "numero" => "7" "paginaInicial" => "807" "paginaFinal" => "818" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29761234" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1007/s00535-018-1476-9" "WWW" => array:1 [ "link" => "https://doi.org/10.1007/s00535-018-1476-9" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rifaximin Treatment for Small Intestinal Bacterial Overgrowth in Children With Irritable Bowel Syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ E Scarpellini \n \t\t\t\t\t\t\t\t """ 1 => """ V Giorgio \n \t\t\t\t\t\t\t\t """ 2 => """ M Gabrielli \n \t\t\t\t\t\t\t\t """ 3 => """ S Filoni \n \t\t\t\t\t\t\t\t """ 4 => """ G Vitale \n \t\t\t\t\t\t\t\t """ 5 => """ A Tortora \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Eur Rev Med Pharmacol Sci" "fecha" => "2013" "volumen" => "17" "numero" => "10" "paginaInicial" => "1314" "paginaFinal" => "1320" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23740443" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Results of small intestinal bacterial overgrowth testing in irritable bowel syndrome patients: clinical profiles and effects of antibiotic trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ M Majewski \n \t\t\t\t\t\t\t\t """ 1 => """ RW McCallum \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Adv Med Sci" "fecha" => "2007" "volumen" => "52" "paginaInicial" => "139" "paginaFinal" => "142" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18217406" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Breath test for differential diagnosis between small intestinal bacterial overgrowth and irritable bowel disease: an observation on non-absorbable antibiotics" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ I Esposito \n \t\t\t\t\t\t\t\t """ 1 => """ A de Leone \n \t\t\t\t\t\t\t\t """ 2 => """ G di Gregorio \n \t\t\t\t\t\t\t\t """ 3 => """ S Giaquinto \n \t\t\t\t\t\t\t\t """ 4 => """ L de Magistris \n \t\t\t\t\t\t\t\t """ 5 => """ A Ferrieri \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.3748/wjg.v13.45.6016" "Revista" => array:7 [ "tituloSerie" => "World J Gastroenterol" "fecha" => "2007" "volumen" => "13" "numero" => "45" "paginaInicial" => "6016" "paginaFinal" => "6021" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18023092" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.3748/wjg.v13.45.6016" "WWW" => array:1 [ "link" => "https://doi.org/10.3748/wjg.v13.45.6016" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Functional 13C-urea and glucose hydrogen/methane breath tests reveal significant association of small intestinal bacterial overgrowth in individuals with active Helicobacter pylori infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ D Enko \n \t\t\t\t\t\t\t\t """ 1 => """ G Kriegshäuser \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clinl Biochem" "fecha" => "2017" "volumen" => "50" "paginaInicial" => "46" "paginaFinal" => "49" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.clinbiochem.2016.08.017" ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Therapeutic efficacy of amoxicillin and rifaximin in patients with small intestinal bacterial overgrowth and Helicobacter pylori infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ P Konrad \n \t\t\t\t\t\t\t\t """ 1 => """ J Chojnacki \n \t\t\t\t\t\t\t\t """ 2 => """ A Gąsiorowska \n \t\t\t\t\t\t\t\t """ 3 => """ C Rudnicki \n \t\t\t\t\t\t\t\t """ 4 => """ A Kaczka \n \t\t\t\t\t\t\t\t """ 5 => """ C Chojnacki \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5114/pg.2018.74228" "Revista" => array:7 [ "tituloSerie" => "Prz Gastroenterol" "fecha" => "2018" "volumen" => "13" "numero" => "3" "paginaInicial" => "213" "paginaFinal" => "217" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30302165" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Activation of the mucosal immune system in irritable bowel syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ VS Chadwick \n \t\t\t\t\t\t\t\t """ 1 => """ W Chen \n \t\t\t\t\t\t\t\t """ 2 => """ D Shu \n \t\t\t\t\t\t\t\t """ 3 => """ B Paulus \n \t\t\t\t\t\t\t\t """ 4 => """ P Bethwaite \n \t\t\t\t\t\t\t\t """ 5 => """ A Tie \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1053/gast.2002.33579" "Revista" => array:7 [ "tituloSerie" => "Gastroenterology" "fecha" => "2002" "volumen" => "122" "numero" => "7" "paginaInicial" => "1778" "paginaFinal" => "1783" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12055584" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1053/gast.2002.33579" "WWW" => array:1 [ "link" => "https://doi.org/10.1053/gast.2002.33579" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ G Barbara \n \t\t\t\t\t\t\t\t """ 1 => """ V Stanghellini \n \t\t\t\t\t\t\t\t """ 2 => """ R De Giorgio \n \t\t\t\t\t\t\t\t """ 3 => """ C Cremon \n \t\t\t\t\t\t\t\t """ 4 => """ GS Cottrell \n \t\t\t\t\t\t\t\t """ 5 => """ D Santini \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1053/j.gastro.2003.11.055" "Revista" => array:7 [ "tituloSerie" => "Gastroenterology" "fecha" => "2004" "volumen" => "126" "numero" => "3" "paginaInicial" => "693" "paginaFinal" => "702" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14988823" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1053/j.gastro.2003.11.055" "WWW" => array:1 [ "link" => "https://doi.org/10.1053/j.gastro.2003.11.055" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The brain-gut-microbiome axis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ CR Martin \n \t\t\t\t\t\t\t\t """ 1 => """ V Osadchiy \n \t\t\t\t\t\t\t\t """ 2 => """ A Kalani \n \t\t\t\t\t\t\t\t """ 3 => """ EA Mayer \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.jcmgh.2018.04.003" "Revista" => array:7 [ "tituloSerie" => "Cell Mol Gastroenterol Hepatol" "fecha" => "2018" "volumen" => "6" "numero" => "2" "paginaInicial" => "133" "paginaFinal" => "148" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30023410" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.jcmgh.2018.04.003" "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.jcmgh.2018.04.003" ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased rectal mucosal enteroendocrine cells, T-lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ RC Spiller \n \t\t\t\t\t\t\t\t """ 1 => """ D Jenkins \n \t\t\t\t\t\t\t\t """ 2 => """ JP Thornley \n \t\t\t\t\t\t\t\t """ 3 => """ JM Hebden \n \t\t\t\t\t\t\t\t """ 4 => """ T Wright \n \t\t\t\t\t\t\t\t """ 5 => """ M Skinner \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1136/gut.47.6.804" "Revista" => array:7 [ "tituloSerie" => "Gut" "fecha" => "2000" "volumen" => "47" "numero" => "6" "paginaInicial" => "804" "paginaFinal" => "811" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11076879" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1136/gut.47.6.804" "WWW" => array:1 [ "link" => "https://doi.org/10.1136/gut.47.6.804" ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CD4+ T cell down-regulation in human intestinal mucosa: evidence for intestinal tolerance to luminal bacterial antigens" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ UY Khoo \n \t\t\t\t\t\t\t\t """ 1 => """ IE Proctor \n \t\t\t\t\t\t\t\t """ 2 => """ AJ Macpherson \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Immunol" "fecha" => "1997" "volumen" => "158" "numero" => "8" "paginaInicial" => "3626" "paginaFinal" => "3634" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9103424" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of different probiotic protocols in irritable bowel syndrome: A network meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ D Liang \n \t\t\t\t\t\t\t\t """ 1 => """ N Longgui \n \t\t\t\t\t\t\t\t """ 2 => """ X Guoqiang \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Medicine" "fecha" => "2019" "volumen" => "98" "numero" => "27" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1097/MD.0000000000016068" ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characteristic dysbiosis of gut microbiota of Chinese patients with diarrhea-predominant irritable bowel syndrome by an insight into the pan-microbiome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ Z Wang \n \t\t\t\t\t\t\t\t """ 1 => """ CM Xu \n \t\t\t\t\t\t\t\t """ 2 => """ YX Liu \n \t\t\t\t\t\t\t\t """ 3 => """ XQ Wang \n \t\t\t\t\t\t\t\t """ 4 => """ L Zhang \n \t\t\t\t\t\t\t\t """ 5 => """ M Li \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1097/CM9.0000000000000192" "Revista" => array:7 [ "tituloSerie" => "Chin Med J" "fecha" => "2019" "volumen" => "132" "numero" => "8" "paginaInicial" => "889" "paginaFinal" => "904" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30958430" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1097/CM9.0000000000000192" "WWW" => array:1 [ "link" => "https://doi.org/10.1097/CM9.0000000000000192" ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Meta-analysis on relationship between Helicobacter pylori infection and irritable bowel syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ MR Li \n \t\t\t\t\t\t\t\t """ 1 => """ MJ Zhang \n \t\t\t\t\t\t\t\t """ 2 => """ W Song \n \t\t\t\t\t\t\t\t """ 3 => """ HH Zhu \n \t\t\t\t\t\t\t\t """ 4 => """ XD Zhang \n \t\t\t\t\t\t\t\t """ 5 => """ NN Zhang \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chin J Dis Control Prev" "fecha" => "2014" "volumen" => "18" "numero" => "10" "paginaInicial" => "976" "paginaFinal" => "979" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2017&filename=ZSYK201702016&v=%25mmd2FVrvys0s%25mmd2FBEY9QQFHNHC%25mmd2Fyje%25mmd2BpMgnYtPXUcvCaNGV8muS4QQhYwSQOHWxe%25mmd2BrMAhi" ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is there an association between Helicobacter pylori infection and irritable bowel syndrome? A meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ QX Ng \n \t\t\t\t\t\t\t\t """ 1 => """ NX Foo \n \t\t\t\t\t\t\t\t """ 2 => """ W Loke \n \t\t\t\t\t\t\t\t """ 3 => """ YQ Koh \n \t\t\t\t\t\t\t\t """ 4 => """ VJM Seah \n \t\t\t\t\t\t\t\t """ 5 => """ AYS Soh \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.3748/wjg.v25.i37.5702" "Revista" => array:7 [ "tituloSerie" => "World J Gastroenterol" "fecha" => "2019" "volumen" => "25" "numero" => "37" "paginaInicial" => "5702" "paginaFinal" => "5710" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31602169" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.3748/wjg.v25.i37.5702" "WWW" => array:1 [ "link" => "https://doi.org/10.3748/wjg.v25.i37.5702" ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack638123" "titulo" => "ACKNOWLEDGMENTS" "texto" => "<p id="para180" class="elsevierStylePara elsevierViewall">We would like to acknowledge the funding received from the Medical Research Project of the Chongqing Health and Family Planning Commission (No. 2016MSXM002) and the TCM Science and Technology Project of the Chongqing Health and Family Planning Commission (No. ZY201802081).</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/18075932/000000750000000C/v1_202211290815/S1807593222003568/v1_202211290815/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/18075932/000000750000000C/v1_202211290815/S1807593222003568/v1_202211290815/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222003568?idApp=UINPBA00004N" ]
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