High level of Pan Lysine Lactylation (Pan-Kla) is found in pancreatic cancer tissues.

H3K18la levels are increased in pancreatic cancer tissues.

H3K18la is related to the severity and prognosis of pancreatic cancer.

Hormone measurement in FNA washout fluid is an accessible method for improving accuracy.

Thyroglobulin (TG) dosage can enhance the accuracy of detecting well-differentiated thyroid carcinomas.

Calcitonin dosage complements cytology in detecting medullary thyroid carcinoma cervical metastasis.

Post-thyroidectoby bed dosages help to determine non-thyroid/parathyroid lesions.

The main cause of hilar obstruction was cholangiocarcinoma (32.9 %) followed by lymph node metastasis (23.2 %).

Technical success was achieved in 91.5 %, clinical success in 60 %.

A significant correlation between clinical success rate was found when at least 50 % of viable parenchyma was drained (p = 0.016; OR = 4.15, 95 % CI 1.4–12.5).

Considering liver sectors, higher clinical success rates were found when at least 2 sectors were drained (p < 0.001; OR = 8.50, 95 % CI 2.7–26.7).

Correlation between unilateral versus bilateral drainage and clinical success was not statistically significant.

Analyzing complaints is essential for identifying areas for improvement.

79 % of the complaints were related to communication issues with the patient.

Improving communication with the patient will help reduce the number of complaints filed.

Using a web application simplifies the management of complaints in primary care.

Most surgeons underestimate the positional and numerical variations of the Facial Nerve.

About 50% of the Marginal Nerves of the Mandible have more than one subdivision.

Just over half of the branches of the Mandibular Marginal Nerve are found below the lower border of the mandible.

The great anatomical variation of the Mandibular Marginal Nerve is responsible for the majority of postoperative motor sequelae.

Harvesting abdominal fat for mFAt knee injection is a safe procedure.

Minor events, such as ecchymosis, mild abdominal discomfort, and mild discomfort at the infiltrated knee are common.

The procedure can be done under local anesthesia, without sedation after single-time preparation.

Despite the efficacy of reconstructive surgeries and Montgomery T-tube, clinical and neurological instability significantly impact outcomes and prolong tracheostomy use.

Treatment for post-intubation tracheal or laryngotracheal stenosis requires a multidisciplinary and personalized approach.

Dysphagia is a significant factor linked to poorer clinical outcomes and extended tracheostomy use.

Photodynamic Therapy (PDT) significantly increased HPV clearance rates in cervical HPV-infected patients.

PDT treatment augmented CD3+ and CD4+ T-cell levels, with sustained elevation observed up to 6 months post-treatment.

A higher CD4+/CD8+ ratio was noted in the PDT group, indicating an enhanced cellular immune response.

Pro-inflammatory cytokines IL-6, IL-8, and TNF-α levels decreased post-PDT, suggesting reduced inflammation.

The total effective rate of treatment in the observation group was higher than that in the control group.

The middle ear resonance frequency of the children in the observation group was higher than that of the control group at weeks 4, 8 and 12 of treatment, and the air-conduction hearing threshold was lower than that of the control group.

The total effective rate of the observation group after 12 weeks of treatment was 92.11 %, which was significantly higher than that of the control group (73.68 %).

The T-ETDQ score of the observation group was lower than that of the control group after treatment.

According to imaging findings of CEUS, TLN was associated with enhanced concentric performance in the arterial phase and heterogeneous enhancement pattern in lymph nodes.

Peak Intensity (PI) of lesions was higher in MLN patients.

Increased age-enhanced concentric performance in the arterial phase, increased PI, and serum PCT above 5.39 ng/mL were independent risk factors for MLN.

The prediction model of serum PCT combined with CEUS had a higher diagnostic value for MLN.

LCA has the ability to suppress the growth, movement, and invasion of glioma cells.

It can also counteract resistance to TMZ drugs.

This opens up new possibilities for identifying clinical drugs to treat glioma patients who are resistant to TMZ.

Eight-section brocade exercises enhance exercise endurance and lung function of COPD patients.

Eight-section brocade exercises improve the physical function of COPD patients.

Eight-section brocade exercises improve patient emotions, nursing efficiency, and satisfaction.

Comparison of the invasive capabilities.

Comparison of the metastatic capabilities.

Effect of CST1 and AKT mRNA in gastric cancer.

Effect of CST1 and AKT protein in gastric cancer.

GpS ameliorates Sev-induced cognitive deficits in rats.

GpS ameliorates Sev-induced neuronal cell damage in rats.

GpS promotes activation of the PI3K/AKT/mTOR pathway.

PI3K/AKT/mTOR pathway inhibitor reduces the amelioration of cognitive deficits in Sev-anesthetized rats by high-dose GpS.

PI3K/AKT/mTOR pathway inhibitor impairs the ameliorative effect of high-dose GpS on neuronal cell damage in Sev-anesthetized rats.

Perioperative Neurocognitive Disorders (PND) can occur in patients submitted to elective surgical procedures under general or regional anesthesia, especially the elderly.

Circadian rhythm disruptions have harmful effects on cognition and may also play a role in the development of PND.

Melatonin 10 mg administered in the perioperative period of TURP surgery for elderly patients hasn't shown any protective effect against postoperative cognitive decline, mainly because the patients have shown a significant improvement in cognitive functions after the surgery.

SARCCalf is better than SARC-F in screening the risk of sarcopenia in PLHIV.

Low CD4+ count, the presence of opportunistic infections, and AIDS status are associated with the risk of sarcopenia in PLHIV, regardless of the tool used.

Lung granulomas have been associated with mycobacteria and fungal infections.

The largest cohort of pulmonary granulomatous lesions in Brazil was studied.

FFPE specimens are a valuable source of material for molecular methods.

Molecular methods contribute to the fast diagnosis of all mycobacteria species.

The findings of the study indicate that Centchroman led to a notable reduction in fibroadenoma size, with a significant proportion of patients experiencing more than 50 % regression in their fibroadenomas.

Patients experienced significant relief from breast pain (mastalgia), showcasing the efficacy of Centchroman in alleviating associated physical discomfort.

Centchroman led to a significant improvement in anxiety and depression scores, highlighting its positive impact on the psychological health and overall well-being of patients.

Electrographic seizures did not have predictive value for adverse neurodevelopmental outcomes at 12‒24 months of age.

The incidence of neurodevelopmental impairment or death was significantly higher in the clinical seizure group.

Only cord blood pH and abnormal brain MRI findings were consistently associated with long-term neurodevelopmental outcomes in a multivariate analysis.

Antithrombotics are the cornerstone for acute Pulmonary Embolism (APE) treatment.

Patients hospitalized with APE in Brazil had a high prevalence of bleeding.

The major bleeding increased the one-year mortality rate.

The bleeding predictive scores assessed showed limited accuracy in identifying high bleeding-risk patients.

Restless legs syndrome is associated with lower information processing speed.

Obstructive sleep apnea is not associated with lower information processing speed.

Managing sleep disorders is critical for improving cognition in multiple sclerosis.

Renal Doppler marker variations within the initial 24 h in sepsis patients.

RRI reduction after 24h of ICU treatment can be used for early detection of SA-AKI.

Critical ultrasound for dynamic monitoring of renal perfusion.

Adverse effects of lenalidomide for Newly Diagnosed Multiple Myeloma (NDMM) cannot be ignored.

Lower-dose PLD administered with dexamethasone and subcutaneous bortezomib is associated with a good durable response.

Lenalidomide is retained as maintenance or salvage therapy if the DVD regimen fails.

After cataract surgery, the prevalence rate of Descemet membrane Detachment was significantly higher in the group with keratome incisions (63.2 %) compared to that with femtolaser incisions (22.2 %).

OSVE and multiple-choice tests can be used interchangeably in the context of formative assessment.

OSVE and multiple-choice tests as effective tools to enhance intern training and monitoring.

OSVE holds promise as a transformative tool, capable of ensuring the continuity and integrity of clinical skills assessment in medical education.

Question – Extension of the biliopancreatic loop increases l-cell activity after surgery bariatric?

Findings – l-cell activity increased independent of extension of the biliopancreatic limb.

Meaning – The additional beneficial effects of long BPL may be due to more rapid delivery of food and bile salts to more distal portions of the intestine.

We identified a distinctive pattern of serum metabolic signatures in juvenile idiopathic arthritis patients under methotrexate therapy.

Methotrexate use is associated with a more efficient mitochondrial function.

A decreased mitochondrial metabolism was observed in polyarticular and systemic JIA subtypes, with a decrease of several acylcarnitines’ concentrations.

Incidence of frailty in elderly patients varies widely among different tools.

FP and FS could be employed as tools for predicting frail conditions.

Different tools had low consistency in predicting frail conditions.

Guidelines recommended pulmonary rehabilitation in COPD.

Self-driven pulmonary rehabilitation is an undertreatment for COPD patients in China.

Chinese patients with COPD have worse clinical conditions.

Treatment with pulmonary rehabilitation at institutes improves clinical outcomes.

Chinese COPD patients are required to be treated as per proper guidelines.

Respiratory symptoms of PACS are associated with high serum Myl9 levels.

Patients who have had COVID-19 can be divided into two groups according to their serum Myl9 levels.

The neutrophil count is correlated with the Myl9 level at 6 months after infection.

circLOC375190 reduction ameliorates neuronal autophagy and apoptosis in tMCAO mice.

circLOC375190 knockdown improves OGD/R-mediated neuronal autophagy and apoptosis.

circLOC375190 affects OGD/R-mediated neuronal apoptosis and autophagy by adsorbing miR-93-5p.

circLOC375190 affects OGD/R-mediated neuronal apoptosis and autophagy by regulating the miR-93-5p/MKNK2 axis.

circLOC375190 affects AIS autophagy by regulating the mTORC1/TFEB axis.

hsa_circ_0000105 modulates malignancy of NPC cells.

hsa_circ_0000105 influences the malignant behavior of NPC via downstream miR-541-3p.

hsa_circ_0000105 positively regulates S100A11 to accelerate the malignant behavior of NPC.

hsa_circ_0000105 inhibits NPC tumor growth in vivo.

Dry eye is more frequent in the urban than in the rural population.

Dry eye is associated with dyslipidemia, visual display terminal, and ocular surface problems.

Dry eye is more frequent in women and the associated factors are associated with antiallergics, chronic pelvic pain, and fibromyalgia.

Dry eye in the elderly has distinct clinical associated factors.

Stem cell therapy is a promising alternative in the spinal cord injury arsenal.

Challenges in stem cell treatment in SCI: phase uncertainty and cell type controversy.

Umbilical cord mononuclear cells may enhance recovery via multiple mechanisms.

Umbilical cord mononuclear cells can promote histological improvement after SCI.

Construction of a personalized risk prediction model for in-hospital mortality in patients with acute myocardial infarction undergoing Percutaneous Coronary Intervention (PCI).

Identification of risk factors associated with in-hospital mortality in AMI patients who underwent PCI.

Development of a nomogram prediction model for in-hospital mortality in AMI patients after emergency PCI.

Evaluation of the nomogram model's effectiveness through c-index, internal validation, Hosmer-Lemeshow test, and calibration curve analysis.

NHANES data from 1999 to 2006 show a positive link between serum CRP levels and low muscle mass risk in US adults.

An inverse J-shaped pattern emerges, indicating a non-linear association between CRP levels and low muscle mass risk, with critical points at 0.273 mg/dL for the overall population, 0.172 mg/dL for males, and 0.296 mg/dL for females.

This nationally representative study underscores the crucial role of inflammation in muscle function and advocates for future research and clinical strategies to address inflammation's impact on muscle mass and function.

Correlation between pathologic complete response and endoluminal complete response.

Half of pathologic complete responses do not achieve an endoluminal complete response.

Gross findings do not perfectly reflect microscopic findings.

ADSCs increased the viability (significantly less necrosis) of a TRAM flap in rats.

Vessel formation in the ischemic segment of the flap was also enhanced by the ADSCs.

Fluorescence microscopy indicated no differentiation of ADSCs into endothelial cells.

Educational value of health expeditions assessed via surveys.

No significant clinical or empathy gains observed.

80 % reported positive career influence from participation.

60 % intend to work within the public health system.

Practical experiences deemed crucial for shaping careers.

Risk factors for depression in peritoneal dialysis patients identified.

Nomogram predicts depression risk in peritoneal dialysis patients.

Gender, income, and comorbidities influence depression risk in dialysis.

Low hemoglobin and uric acid levels are linked to higher depression risk.

Developed nomogram shows strong clinical applicability and accuracy.

The use of LARCs reduces unplanned pregnancies.

Single-visit placements of LARCs increase access and uptake.

Train and allowed nurses on the placement of LARCs is important to women access and uptake.

Expand the knowledge of non-contraceptive benefits of LARCs is important among providers and users.

The original variant was responsible for most of the cases that evolved with death, omicron seems to be responsible for milder symptoms when compared to delta.

Children between 1‒6-months of age account for most of the cases, which concerns since there is no vaccination coverage.

Receptors have chemotactic property cells and are characterized as inflammatory markers.

Monocyte subtypes can play an important role in the Chronic Venous Disease scenario.

Receptors that act by recruiting monocytes include CCR2, CCR5, and CX3CR1.

Chronic Venous Insufficiency changes the monocyte phenotype.

The chemokine receptors might be changed by the Chronic Venous Insufficiency.

Multi-omics study is promising to improve the sensitivity and specificity of screening for NSCLC.

The risk score of Metabonomics, radiomics and multi-omics had different levels of performance in different risk groups.

Multi-omics model is more effective in the non-invasive diagnosis of pulmonary malignant nodules.

miR-519d-3p affects the antitumor effect of 5-FU on CRC cells.

miR-519d-3p could regulate PFKFB3 and could have a significant effect on CRC.

PFKFB3 attenuated 5-FU sensitivity in CRC cells and enhanced glycolysis.

History of venous thromboembolism, d-Dimer as well as ETP, APTT coagulation indices, and Wells score were significantly higher in the AECOPD with PE group, and ttpeak, ALB and TP were lower.

Wells score had a positive correlation with ETP and APTT and a negative correlation with ttpeak, which were all independent risk factors for PE in AECOPD.

Wells score, ETP, APTT and ttpeak had the efficacy of predicting PE by ROC curve analysis.

Power Doppler as a Predictor: In hand ultrasound of women with early rheumatoid arthritis, Power Doppler was a significant predictor of therapeutic failures.

Important Power Doppler Scores: The total Power Doppler score, wrist Power Doppler score, and metacarpophalangeal Power Doppler score were the most critical predictors of therapeutic failures.

Clinical Implications of Power Doppler: The use of Power Doppler can help clinicians identify the risk of therapeutic failures in women with early rheumatoid arthritis, allowing for early intervention and treatment adjustments to improve patient outcomes.

Pembrolizumab is effective for GTN multi-drug resistant treatment.

Pembrolizumab seems also effective for PSTT/ETT treatment.

Pembrolizumab efficacy is similar in cases of resistance or GTN relapse.

Fibroids are tumors that can cause important symptoms that reduce women's quality of life.

The gold standard treatment for symptomatic fibroids is hysterectomy.

Myomectomy is the treatment of choice for women with reproductive desire.

Magnetic resonance-guided focused ultrasound for uterine fibroids is a minimally invasive treatment alternative for symptomatic women.

Magnetic resonance-guided focused ultrasound for uterine fibroids proves to be a good alternative to improve the symptoms and quality of life of symptomatic women.

Adding Lymphocyte to Monocyte Ratio (LMR) to CHA2DS2-VASc score improves its reclassification ability and is comparable with the ABC score in predicting stroke.

Adding a systemic inflammation score (using LMR, albumin and fibrinogen) to CHA2DS2-VASc score improves its predictive and reclassification ability and is comparable with the ABC score in predicting death.

Because traditional inflammatory biomarkers are more readily available and less expensive, they may be used to improve decision support for AF.

High levels of HMGB1 in AOSC bile are associated with the risk of septic shock.

AOSC bile HMGB1 is significantly correlated with blood CRP.

Elevated HMGB1 in AOSC bile increases the risk of postoperative complications.

Abnormal Uterine Bleeding (AUB) is the leading cause of seeking gynecological care, with data showing that 3 in 10 Brazilian women have this condition, with intermenstrual bleeding standing out.

According to the International Federation of Gynecology and Obstetrics (FIGO), cycles lasting less than 24 days or more than 38 days, with menstrual flow lasting eight days or more and blood loss reported by the woman as intense, are considered abnormal.

The main causes of AUB are summarized in the mnemonic PALM-COEIN, dividing them into structural and non-structural causes.

Diagnosing the etiology of AUB is essential to establish specific treatments, directed at the cause, which can be clinical or surgical, aiming not only to control the amount of blood loss, but also to improve the quality of life of women with AUB.

In general, the first line of treatment for AUB is medication, with surgical treatment being intended for failure or contraindication to clinical treatment or in cases of significant hemodynamic instability.

Uterine fibroids adversely impact maternal and neonatal outcomes.

UAD parameters and PAPP-A levels do not markedly associate with the fibroid size.

UAD and PAPP-A play functional roles in determining the outcomes of pregnancies carrying fibroids.

Normal ranges of fetal weight as a function of gestational age was created.

New parameter, days before birth, was incorporated for normal ranges of fetal weight.

Parameter days before birth is useful for estimating fetal weight at scheduled birth.

A comprehensive systematic review was conducted, to provide healthcare workers with a vital resource in the treatment of eyelid malposition, our search spanned electronic databases, clinical trials registries, and relevant journals.

The study includes 15 selected trials evaluating 709 patients (855 eyelids), with an assessment of trial quality using the Cochrane Risk-of-Bias tool (RoB V2).

Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder.

With correct screening and diagnosis, treatment must be offered to improve prognosis.

Adequate treatment in a healthcare setting must be known.

The Early Start Denver Model (ESDM) showed improvements in the cognitive, verbal, and social aspects.

Time occasionally can improve some scores independently of the group.

Ethnopharmacological knowledge is passed down through generations by women in the community, who use plants especially for sexual and postpartum care.

Knowledge was low mainly about contraceptive methods of high effectiveness.

The acceptance of the chosen contraceptive method by deaf women was satisfactory.

There are no intervention studies to improve contraceptive use among deaf women.

Mitochondria regulate cellular functions, and mtDNA mutations can affect metabolism.

mtDNA mutations are promising biomarkers for cancer detection and tumor progression.

These mutations might influence therapy response, drug resistance, and patient outcomes.

Tools and models advance precision oncology and mitochondrial-targeted treatments.

• NMES+ can improve the aerobic capacity of individuals in functional decline.

• NMES+ appears to improve physical functional capacity in general.

• More RCTs are needed to better evaluate the evidence found.

Sexual dysfunction is a common side effect of antidepressants, especially in women.

Identifying effective pharmacological treatments for Antidepressant-Induced Sexual Dysfunction (AISD) is crucial for enhancing patient quality of life.

Bupropion at a dose of 150 mg has shown greater effectiveness in treating AISD in women.

The meta-analysis found no direct correlation between improvements in sexual function and reductions in depressive symptoms.

Colorectal cancer is one of the most common neoplasms and a leading cause of cancer-related mortality worldwide.

The treatment of colorectal neoplasia has evolved significantly over the past few decades due to advances in minimally invasive techniques.

Although conventional surgery remains the gold standard for rectal tumors, ESD, TEM, and TAMIS emerged as effective and less invasive therapies for benign tumors and early cancers without nodal metastases, allowing lower morbidity.

ESD and TES are safe and effective treatment options for early-stage rectal tumors.

Molecular and IHC markers aid in objective classification and outcome prediction of PT.

Surgery is the gold standard for PT, but margin extent lacks consensus.

Local recurrence is key in PT prognosis, with margin status as the main risk factor.

Adjuvant radiotherapy lowers recurrence in borderline/malignant PTs with close margins.

Errors during patient care are a huge source of ethical, financial, and even mental problems affecting patients, physicians, and healthcare organizations.

Open disclosure is a process for ensuring that open, honest, empathic and timely discussions occur between patients and/or their support person(s) and healthcare staff following a patient safety incident.

Physicians may avoid or hide errors or blame other health professionals.

Adopting an effective disclosure system, increases the possibility of an agreement between the parties involved, meaning significant savings in financial resources.

Patients want some attitudes from their doctors: an explicit statement that an error occurred and an apology.