This is the first time to verify the targeting regulation of miR-96-5p on LDB2.

MiR-96-5p/LDB2 regulates cellular behaviors through ERK1/2 signaling pathway in lung cancer H1299 cell.

Lnc-ZFAS1 is highly expressed in osteosarcoma.

Lnc-ZFAS1 could promote cell proliferation, migration, invasion and EMT in vitro.

Lnc-ZFAS1 acted sponger of miR-520b and miR-520e to promote RHOC.

The downregulation of miR-653-5p is involved in the progression of LP.

MSCs-derived exosomal miR-653-5p suppressed the malignant behaviors of LP cells.

The role of MSCs-derived exosomal miR-653-5p in LP relied on BZW2.

• Prevalence of dysarthria in SPG4 is greater than previously considered.

• The dysarthria in SPG4 is mild or moderate.

• The subsystems of speech more affected are articulatory and phonation.

Desmoid Tumors in Familial Adenomatous Polyposis are a huge problem in these patients, the ability to prevent desmoid development is limited.

Some clinical and surgical variables were identified as unfavorable and associated with a greater risk.

This variable may be useful during the decision-making process.

It can take days to get the result of blood culture.

CBC and CRP are readily available exams and could be used to predict blood culture.

ML algorithms based on CBC and CRP couldn't predict neonatal blood culture positivity.

This study provides evidence that CoronaVac, an inactivated virus vaccine against SARS-CoV-2, is safe and has a moderate immunogenicity in AAV.

The authors identified that immunogenicity is negatively influenced by glucocorticoids.

A mild antibody decay occurs in 6-months with a good response with a booster dose, although lower than health controls.

LGBT+ people can face several inequalities in access to healthcare.

LGBT+ people performed fewer preventive exams than their non-LGBT+ peers.

The worst access score was found in black LGBT+ over 50 years old.

Liver abscess patients with diabetes mellitus have featured presentations.

Liver abscess patients with diabetes mellitus have featured changes after therapy.

Liver abscess patients with diabetes mellitus cannot have a better therapeutic effect.

Malignant hilar biliary stricture had a high technical success rate but suboptimal clinical success rate.

At multivariable logistic-regression analyses, Bismuth IV strictures were related to higher clinical failure rates when compared to other strictures levels.

There was a trend towards higher failure rates with increased levels of pre-drainage bilirubin level, although not statistically significant.

miR-96-5p and 182-5p are associated with FOXO3a dysregulation and cancer.

FOXO3a and miRNAs represent molecular markers in Brazilian breast cancer patients.

cIMT is associated with diabetes.

Subclinical hypothyroidism was not associated with cIMT.

No additive effect over cIMT was detected in patients with both diseases.

The proportion of Pap smears remained at a high level (>89%) from 2003 to 2015 in São Paulo.

The offer of exams was expanded, more significantly for mammography and PSA, especially among the less educated group.

Were identified inequalities in access to cancer screening due to education, being more expressive for mammography and PSA tests.

What Is New?

Short-term (7-day) DAPT with intensive rosuvastatin can quickly and effectively relieve the clinical symptoms for patients with mild-to-moderate AIS within 21-day.

Short-term (7-day) DAPT with intensive rosuvastatin significantly can reduce recurrent ischemic stroke for patients with mild-to-moderate AIS within 90-day.

Short-term (7-day) DAPT with intensive rosuvastatin rarely increased bleeding events, statin-induced liver injury, or statin-associated myopathy in patients with mild-to-moderate AIS.

What are the clinical implications?

Short-term (7-day) DAPT with intensive rosuvastatin might be a good alternative therapy regimen for mild-to-moderate AIS.

The frequencies of abnormal emotional SDQ scores from adolescents with chronic diseases were significantly lower than those of healthy controls during the COVID-19 pandemic.

The frequencies of abnormal hyperactivity and inattention SDQ scores from adolescents with chronic diseases were significantly lower than those of healthy controls.

Abnormal emotional scores from adolescents with chronic diseases were as independently associated with female sex, poor sleep quality, and intrafamilial violence during the pandemic.

Abnormal hyperactivity and inattention SDQ scores from patients were inversely associated with total PedsQL score, changes in medical appointments during the pandemic, and reliable COVID-19 information remained.

What does interfere with the virtual task of driving?

Older adults require a longer adaptation time to the driving simulator.

Main predictors of braking time are age e muscle strength.

The exponential growth of telehealth services during the COVID-19 pandemic led to the implementation of a telemedicine care service in a tertiary university pediatric hospital. It brought the need to develop a training aimed at remote care within the pediatric emergency.

This descriptive prospective study with 40 pediatric resident physicians describes an innovative proposal for training in telemedicine.

The preliminary results were encouraging, demonstrating the program's potential in training future pediatricians.

Amygdala is involved in the control of cardiorespiratory functioning.

KCC2, α1-Na+/K+-ATPase and GFAP changes were observed in the amygdala after SE.

The changes in chloride regulation may contribute to SUDEP.

Pneumonectomy for benign disease is a high-risk procedure performed for a variety of indications.

Patients with benign conditions would be expected to have superior long-term survival in comparison with those with malignancy.

Morbidity is often significant, with a meticulous operative technique and detailed patient management, which can be similar to a pneumonectomy performed for malignancy.

Pneumonectomy for a benign disease should continue to be considered a treatment option for carefully selected patients.

HIV viral resistance in pregnancy.

Adverse perinatal outcomes in pregnant women living with HIV.

Perinatally acquired HIV can increase the risk of viral suppression failure.

Proximal humeral fractures can progress to humeral head osteonecrosis

It's controversial if the Hertel classification can predict humeral head osteonecrosis.

Proximal Humeral Fractures can be fixed through the anterolateral approach.

Objective: to correlate the Hertel's predictors with the humeral head osteonecrosis.

Hertel's criteria were not able to predict the risk for humeral head osteonecrosis.

The overall prevalence humeral head osteonecrosis was 17.9%.

The aim is to explore NSE and SCC in patients with lung cancer before and after radiotherapy.

Total of 82 patients with lung cancer were selected as the study group.

NSE and SCC levels can preliminarily evaluate the effect of radiotherapy.

High KCNK9 expression level is correlated with colon cancer patients' poor survival.

KCNK9 promotes proliferation, migration, invasion, EMT, and Wnt signaling pathway.

KCNK9 mediates the inhibitory effects of genistein on colon cancer liver metastasis.

BMMSC-CM therapy on rats with DFUs enhanced the wound healing process.

It accelerated wound closure and promoted cell proliferation and angiogenesis.

It enhancd cell autophagy and reduced cell pyroptosis in ulcers.

The number of total CTCs and MCTCs had a strong correlation with Tumor-Node-Metastasis (TNM) stages (p < 0.05), Progression-Free Survival (PFS), and Overall Survival (OS).

The patients with > 7 CTCs or > 5 MCTCs per 5 mL blood had poorer PFS.

The PFS of the patients with chemotherapy combined targeted therapy had shorter PFS than that of the patients with chemoradiotherapy.

The patients with > 4 CTC counts change between pre-treatment and post-treatment had shorter PFS survival rates and overall rates (p < 0.05).

Prenatal androgen exposure reduced the desire for motherhood in 46, XY women.

46, XY DSD people who changed from female to male gender presented similar sexual parameters as those assigned as males.

Among females, virilized genitalia at birth did not affect sexuality once the surgical treatment is completed.

Fertility desire is shared among 46, XY DSD people, regardless of gender.

• Evaluation of disagreement between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases.

• 30% of the adolescents with chronic diseases had major discrepancies between clinical diagnosis of death and autopsy findings, mainly caused by infections.

• Pneumonia, pulmonary abscess, as well as isolation of yeast and virus were identified at autopsy findings in the groups with major discrepancies.

There is a high prevalence of depressive symptoms in patients with Crohn's disease.

Depressive symptoms are related to the active disease.

According to the Montreal classification, the penetraing behavior of Crohn's disease, was less related a rates of depression than inflammatory behavior disease.

Prone position in intubated patients with COVID-19 improves gas exchange.

Elderly and severe comorbidities increase mortality risk after prone sessions for ARDS-COVID-19.

ARDS-COVID-19 better respond when prone is applied early in patients with good health status.

Prediction scores can be used to support clinical decisions and resource allocation.

The authors used data from 3,022 hospitalized patients with COVID-19, of whom 1054 died.

The final scores included age, comorbidities, and baseline laboratory data.

Accuracy was 75% for ICU admission and 77% for death in the validation sample.

Our scores were more accurate than the previous NEWS-2 and 4C Mortality Scores.

VTE COVID-19 patients were sicker, their hospital stay was longer, and they were more likely to die.

VTE incidence is still considerable in COVID-19 patients even under pharmacological prophylaxis.

Prophylaxis and treatment compliance are essential to achieve a low VTE incidence.

The retrospective study included 73 cGBM patients, which was the largest patient cohort in east Asia to date.

OLIG2 expression level was high in more than half cGBM patients (42/73, 57.5%).

OLIG2 expression level could be used as an independent prognostic factor for cGBM patients.

β-catenin protects cardiomyocytes against H2O2-induced apoptosis.

CIL56 restored apoptotic cell death in H2O2-treated cardiomyocytes, reversing the effects of β-catenin.

The β-catenin/YAP axis may be a target for the treatment of acute MI.

Unilateral transtibial amputees and functional deficits.

Concurrent training proved to be effective.

Paralympic athletes should review their physical training.

Hirschsprung's disease is a congenital disorder characterized by intestinal sub-occlusion and the absence of neurons in the enteric nervous system, with involvement of varying segments of the large intestine.

The treatment is only surgical, for this reason the diagnosis must have a good accuracy.

This research demonstrates a simplified method to perform the diagnosis with 93% of accuracy.

The use of this method brings benefits to the patient, the pathologist, and the service.

Decreased phenylephrine-induced vascular reactivity.

Increased production of NO.

Increased in H2O2 production.

Pregnant women with severe pulmonary hypertension have a higher risk of mortality.

Pulmonary artery systolic pressure is associated with maternal mortality.

Screening before pregnancy and multidisciplinary monitoring are crucial.

Laser engraved stent has easy deployment & has better follow-up outcomes.

Success of coil embolism would be higher for braided stent-assisted embolization.

Braided stent should be preferred for the posterior circulation aneurysm.

Neobaicalein ameliorates isoflurane-induced cognitive impairment in neonatal mice.

Neobaicalein reduces isoflurane treatment-induced inflammation.

Neobaicalein reduces isoflurane-induced apoptosis of hippocampal neurons through the p-CREB1 pathway.

Extended criteria donor organs in heart-lung transplant do not worsen mortality.

Advanced donor age and P/F ratio remain predictive of mortality.

Extended criteria donor organ use is safe in appropriately chosen patients.

miRNA-122 in cerebral infarction.

miRNA-122 may be involved in the pathological process of ACI.

miRNA-122 related to the degree of neurological impairment and short-term prognosis in patients with ACI.

Decision support systems that can predict the diagnosis of malignancy for pleural effusion will help physicians in patient management.

Advances in computer-aided diagnostic analysis of CT images and obtaining a pre-diagnosis of pleural fluid may reduce the need for interventional procedures by guiding physicians about which patients may have malignancy.

Image-based decision support systems enable early diagnosis and treatment by saving cost and time in patient management.

The present results support the potential of TPPU to be a multi-functional therapeutic approach for oral ulcers by targeting soluble epoxide hydrolase.

To provide a new idea for the treatment and prevention of clinical oral ulcers.

Analyzing predictors of survival in patients with ovarian carcinoma is crucial.

Independent estimators of mortality in ovarian carcinoma, are more precise by identifying histopathologic tumor grade, FIGO, and NACT.

The aforementioned predictors also involve the number of therapeutic cycles, type of surgery, and chemotherapy response.

Poor chemotherapy response increases the hazard ratio for mortality.

Significant predictors of survival in ovarian carcinoma are the absence of recurrent disease and lymphovascular space invasion.

FKBP10 proteins are highly expressed in lung adenocarcinoma, including brain metastasis tissue.

FKBP10 is a valuable prognostic indicator for lung adenocarcinoma.

FKBP10 is a potential clinical biomarker for lung adenocarcinoma.

This study aimed to find the clinical significance of the extracapsular extension in sentinel lymph nodes on the number of additional involved axillary lymph nodes, overall survival, and disease-free survival.

One hundred twenty-eight patients with positive sentinel lymph nodes were separated into two groups according to the presence or absence of ECE and following during 10 years.

There was found a positive correlation between the presence of ECE and the number of additional positive lymph nodes. Therefore, this does not impact overall survival, and disease-free survival in a follow-up of 10 years.

ML can be a practical and effective early prediction method of AP complicated by ARDS.

PaO2, CRP, PCT, LA, Ca2+, NLR, WBC, and AMY were used as the optimal subset of features to early identify AP patients with a high risk for developing ARDS in ML.

BC was the superior predictive model and EDTs could be promising for predicting large samples.

Clinical features, prognostic indexes and echocardiographic parameters may contribute together to better define survival chances in CDH.

When antenatal factors are not available, postnatal factors can be good predicting tools and may suffice to assess the prognosis of CDH patients.

To comprehensively assess the safety and efficacy of hypothermia in ischemic stroke.

Articles published were searched from Google scholar, Baidu scholar and PubMed.

The results showed that hypothermia treatment was correlated with mRS≤2 at 3 month.

Perianal Crohn's disease is the main risk factor for anal cancer in IBD patients.

Perianal Crohn's disease patient has a chance of HPV 3.29 time higher than control.

High risk HPV is numerically twice as prevalent in perianal Crohn's disease patient.

Experimental evidence suggested that hypoperfusion could impact organ viability.

High eNOS-expression in female rats favored the maintenance of renal perfusion.

BD-female rats showed progressive inflammatory responses.

A8 treatment inhibits CFA-triggered inflammatory pain.

A8 treatment exerts a significant inhibitory effect on the production of pain-associated pro-inflammatory cytokines.

A8 increased the signal transduction of the TRPV1 and CGRP.

This is a pioneer study investigating VTE in breast surgery patients in Brazil.

Patients undergoing SSM or NSM, immediate breast reconstruction – especially abdominal flap – and procedures longer than four hours had a higher incidence of VTE events.

Neoadjuvant chemotherapy and LMWH were associated with a lower incidence of thrombotic events.

IL-1β and AMH were lower, and IL-6 was higher in the endometriosis group.

The treatment significantly decreased dysmenorrhea, dyspareunia, and cyst diameter.

The treatment had no significant effect on the IL-1β, IL-6, and AMH levels.

Signs and symptoms of COVID-19 at hospital admission are similar between patients infected with HIV and controls.

Mortality from COVID-19 in patients infected with HIV was higher compared to the controls in 2020, but no difference in 2021.

Similar rates of ICU and invasive mechanical ventilation were observed in the different waves.

The seroprevalence of SARS-CoV-2 antibodies in Brazil in 2020 was 11%.

Seroprevalence increased with time, 1% in the first and 83% in the last quarter of the year.

Seroprevalence was higher in the Northern region, decreasing as one moves south.

COVID-19 pandemic was associated with an increase in healthcare-associated infection.

For the majority of microorganisms, the proportion of resistance did not increase.

The large spectrum antibiotic consumption increased disproportionately during the pandemic.

Combination of clinical factors and radiomic features to construct models for predicting IDH1 gene mutations in glioma.

Multiparametric and multiregional MR images were used to achieve more accurate prediction performance.

The model performance with different regions of interest for different sequences was compared.

Acute lymphoid leukemia changes the central auditory pathway.

Changes in the central auditory pathway in individuals with acute lymphoid leukemia are due to neurotoxicity.

Elevated level of MLR associated with higher AAC score.

Each 0.1 unit of increased MLR was associated with a 14% increased risk of severe AAC.

This positive relationship between MLR and AAC score was stronger in the elderly and with diabetes.

Analysis of recovery from cardiopulmonary exercise testing reveals pathophysiology.

Recovery of respiratory gases from peak exercise is hindered in heart failure.

Recovery from peak exercise in heart failure is negatively correlated with peak VO2 but not baseline LVEF.

MEG3 expressed exceptionally low in the ectopic endometrial.

Overexpression of MEG3 inhibits hESCs proliferation and invasion.

MEG3 is a ceRNA that has regulatory effects on miR-21–5p/DNMT3B axis.

DNMT3B inhibits Twist expression after upregulation of MEG3 action.

Fructosamine and HbA1c are associated in individuals with diabetes and cancer, even on chemotherapy.

HbA1c and fructosamine are associated with self-monitoring of blood glucose in cancer.

The association between fructosamine and HbA1c occurs even in anemia and hypoproteinemia.

MCP enhanced ARPE-19 CA, proliferation, migration, invasion, and cytokine expression.

MCP can promote the further development of PVR.

The inhibition of MCP may be the key to the treatment of PVR.

Insufficient vitamin D levels and sufficient vitamin D levels had a lower risk of ICPP.

The vitamin D levels in ICPP girls could affect by height, weight, breast stage, mother's height, and luteinizing hormone/follicle-stimulating hormone ratio.

The results could affect by the imbalance of girls in vitamin D deficiency, insufficiency, and sufficiency groups.

miRNA-seq analysis obtained 1,002 differentially expressed miRNAs.

Differentially expressed miRNAs were mainly enriched in axon guidance, regulation of the actin cytoskeleton and the MAPK signaling pathway.

10 miRNAs (miR-1306-5p, miR-196b-5p, miR-19a-3p, miR-22-3p, miR-320b, miR-34a-5p, miR-485-3p, miR-489-3p, miR-501-3p, and miR-487-3p) were found to be associated with the most sensitive and specific pathways for MMD prediction.

GM1 has neuroprotective effects, but it may face difficulty with the blood-brain barrier.

Intrathecal application in models of spinal cord injury induced in rats.

Determination of optimal timing of GM1 application for best functional results.

WWI was a potential predictor for cardiovascular mortality with a cut-off of 11.33.

Higher WWI associated with an increased 95% risk for cardiovascular mortality.

Higher WWI associated with an increased 68% risk for all-cause mortality.

HMG-CoA reductase inhibitor statins can inhibit vascular remodeling.

The regulation of HDAC2/NF-κB signaling pathway can improve pulmonary vascular remodeling.

Atorvastatin can be used in the early intervention of pulmonary vascular remodeling.

Pharmacological modulation of cardiac receptors can be an efficient therapeutic strategy to increase life expectancy in Parkinson's disease.

Patients with opioid use disorder experience greater in-hospital mortality and readmissions following MI.

Paradoxically, these patients experience superior cardiovascular outcomes compared to their counterparts.

Opioid use disorder remains associated with high resource utilization and healthcare expenditures.

Aging impairs binaural interaction in cortical and subcortical regions, elderly people with hearing loss show differences in responses between the ears/electrodes.

Elderly people without hearing loss show differences in responses between the hemispheres.

Binaural interaction is more impaired in older adults with high-frequency hearing loss.

m6A modification participates in the development of BPD.

METTL3 promotes the pyroptosis of BEAS-2B cells.

ETTL3-mediated m6A modification of ATG8 disrupts the interaction between ATG8 and GSDMD.

MiR-15a/β1,4-GalT-I axis inhibits ECM degradation and senescence in chondrocytes.

MiR-15a inhibits β1,4-GalT-I expression with post-transcriptional modifications.

β1,4-GalT-I promotes NF-κB phosphorylation to exacerbate osteoarthritis.

Intra-articular injection of miR-15a attenuates cartilage degeneration in vivo.

6-OHDA lesioned striatum without changes in CCC cotransporters and Na+/K+-atpase.

However, was observed astrocytic reactivity.

Dopaminergic degeneration was followed by changes in connexin-36.

EGFR, POLE, and PB1 genes had high mutated frequency in the patients with relapse and metastatic cancer.

PBRM1, BAP1, KDM5C, and BAP1 genes were critical for the overall survival.

Wild-type PBRM1 and mutated BAP1 were key indications for the predication of OS.

Exercise training can enhance motor function and improve the spinal cord.

Exercise training can improve gastrocnemius muscle morphology.

Exercise training can promote neurological recovery after spinal cord injury in rats.

Infertility is caused by heterogeneous risks, but most of them are unexplained.

Sperm DFI diagnostic value was controversial as not rule out male sperm parameters.

Whether DFI was a useful indicator for embryologists and clinicians in UEI couples.

Gestational trophoblastic neoplasia responds to anti-PD-1 or anti-PD-L1 immunotherapy.

Multi-drug resistant gestational trophoblastic neoplasia may achieve remission with pembrolizumab.

Ultrasound-guided PTCD improves treatment effect for AOSC combined with septic shock.

Ultrasound-guided PTCD reduces stress response for AOSC combined with septic shock.

Ultrasound-guided PTCD assists patients smoothly to pass preoperative critical period.

LEP may be associated with the development of PCOS.

LEP may be a protective factor against apoptosis in GCs treated with insulin.

LEP knockdown induced JAK1/STAT3 activation could be reversed by administration of curcumin.

Temperature-Related Illness (TRI) describes physiologic aberrations that occur secondary to exposure to extreme cold or heat.

Individuals with Atrial Fibrillation (AF) who present with TRI may be at increased risk of poor outcomes relative to patients without TRI.

Our analysis shows that individuals with AF who develop a cold-related TRI face an increased risk of mortality as compared to those without TRI.

Notch2 is important in trastuzumab-induced cardiomyocytes apoptosis through JAK2/STAT3 pathway.

Trastuzumab promotes cell apoptosis and causes cardiomyocyte injury.

Notch2 may be a potential target of trastuzumab-induced myocardial injury.

Several environmental and genetic factors may cause oral clefts.

Iron supplementation use of folic acid are protective factors for oral fissures.

Passive smoking during pregnancy can be a risk factor for oral clefts.

Dysphagia has a high incidence in post-stroke patients.

Alternative long-term feeding method indication in post-stroke patients.

Dysartrhia associated dysphagia in post-stroke patients.

Activation of the NFκB signaling pathway aggravates myocardial injury.

Vav3 might exert an effect in MI model by repressing the NFκB signaling pathway.

Vav3 exerted its cardio-protective function in a NFκB-dependent manner.

CLINICS-D-23-00277_Original Article

Studies have shown worse rotational stability in the presence of a supposed ALL injury combined with an ACL injury. However, there is no evidence, so far, on how individuals behave regarding muscle strength and functionality.

Knee and hip muscular functions are impaired after an ACL injury and do not seem to be influenced or worsened in individuals with greater rotational instability with clinical indications for combined reconstruction of the anterior cruciate and the anterolateral ligaments of the knee.

The ACL+ALL group showed a significantly shorter distance achieved in the Crossover Hop Test than the other groups, as well as the reports of more pain during the tests.

Cystic fibrosis related vascular complications.

Survival of people with cystic fibrosis.

Cystic fibrosis related vascular complications and metabolic complications.

Identification of potential candidates for hand surgery in Systemic Sclerosis.

Presence of digital ulcers increases the likelihood of surgical indication.

Development of a predictive tool to identify candidates for surgical treatment.

The involvement of TMEM26, a novel plasma membrane protein, in cancer EMT was examined for the first time.

The discovery of TMEM26 and its regulation on the tight junction activates NF-κB signaling as a novel therapeutic target of metastatic ESCC.

A mechanism that directly controls the assembly of tight junctions at the plasma membrane, which affects a plethora of signaling pathways, was discovered.

The oral glucose tolerance characteristics were analyzed.

Effect of gestational diabetes on the pregnancy outcome of twins was analyzed.

The influence of preconception BMI on twin pregnancy outcome was explored.

This study describes the implementation of an organized colorectal cancer (CRC) screening in an urban low-income community.

Quantitative fecal immunochemical test (FIT) followed by colonoscopy is an efficacious strategy to improve the adenoma detection rate and CRC.

FIT followed by colonoscopy ensued a high participation rate, and high predictive positive value for adenoma and CRC.

A stent-assisted thrombectomy can use in symptomatic intracranial hemorrhage.

Contact aspiration plus stent retriever catheters have high chances of reperfusion.

Contact aspiration + stent retriever has fewer disease-related adverse effects.

The reperfusion parameter should be used to evaluate mechanical thrombectomy.

Failure attempts increased procedural time and procedural-adverse effects.

Understanding the costs of neonatal sepsis helps to provide the problem's dimension.

Mean hospital cost for neonatal sepsis was US$ 3345.59 per patient in 2008‒2018.

Improvement in quality of care may decrease neonatal sepsis’ economic impact.

Score to predict successful RRT discontinuation in AKI.

Timely catheter removal.

Comparison among different strategies to assess.

Creatinine variation.

No difference in long-term continence in extraprostatic vs. organ-confined prostate cancer.

Even after multivariable adjustment, no difference between these two groups was identified.

A mutation reported in this article appeared to be a definite pathogenic mutation of LQT2.

This mutation exhibit gender differences in clinical symptoms and T-wave morphology.

The female proband with this mutation showed a positive reaction to lidocaine attenuation test.

The status of the thyroid gland and metabolic disturbance leads to the alteration of oxygenation.

The cases undergoing cesarean section had significantly higher values of the pulsatility index.

The cases with cesarean section had significantly higher values of the cerebroplacental ratio.

Exercise, one of the most crucial and beneficial health habits, is not a common practice among the general population.

Data on exercise were mainly from trainees, with few from professional doctors.

Nearly half of the 1187 doctors in the study had low-level exercise with young age, female, hard work, poor diet, and irregular health surveillance as risk factors.

Supportive therapies are essential for maintenance of the muscle strength and quality of life.

Some quality of life parameters are hampered after soft tissue sarcoma treatment.

Soft tissue sarcoma treatment does not interfere with the functionality of the operated limb.

Total Knee Arthrosplasty (TKA) candidates often have associated neuropathic pain.

Patients with gonarthrosis and neuropathic pain have worse functional scores.

TKA candidates should be assessed for the presence of associated neuropathic pain.

Auditory processing behavior of children diagnosed with stroke was analyzed.

Children and adolescents with stroke performed worse in auditory processing tests.

Stroke-related lesions compromise the auditory neural mechanisms.

ANRIL is a better diagnostic indicator than cardiac troponin I in patients with stable angina.

The levels of ANRIL are higher in patients with stable angina than those with myocardial infraction.

The levels of ANRIL in peripheral plasma could be used as a good biomarker for stable angina.

No significative adverse effects were reported following the Radiofrequency protocol.

Radiofrequency was comparable in efficacy to estrogen for vulvovaginal atrophy.

Radiofrequency could be a viable option in vulvovaginal atrophy management.

Study on predictive value for HCA among women with PPROM after undergoing cervical cerclage.

WBC and neutrophil can predict HCA among women with PPROM after surgery of cervical cerclage.

The study provides a valuable prediction tool for early detection of HCA.

Examined resistin gene polymorphisms' link with AAA.

-420C>G (especially CC/CG) tied to AAA risk & progression.

+276G/T polymorphism showed no AAA association.

Resistin gene's potential role in AAA highlighted.

The incidence of insomnia is higher in the acute ischemic stroke population.

Insomnia is closely related to the clinical outcome of acute ischemic stroke with large vessel occlusion.

The effects of Insomnia on acute ischemic stroke may involve inflammation and oxidative stress mechanisms.

Value-based models might improve care for heart failure.

The authors observed poor QoL and high treatment costs in HF outpatients in Brazil.

Women seem to have worse quality of life, more anxiety and depression symptoms.

MiRNA-218-5p up-regulates ErbB2 and EGFR expression by suppressing LRIG1 expression.

MiRNA-218-5p promotes the malignant behaviors of BC.

MiRNA-218-5p may exert a pro-tumor effect on BC and serve as a therapeutic target for BC treatment.

Dalpiciclib + fulvestrant is effective in hormone (+) and HER2 (−) breast cancers.

Dalpiciclib and buparlisib cause neutropenia.

Gastrointestinal tract-related adverse effects while treatment with fulvestrant.

Liver function monitoring is recommended for ribociclib + letrozole treatment.

Women should be under the supervision of a consultant while 100 mg/day of buparlisib.

MPT combined with THSD shows remarkable efficacy in hyperplastic scar patients.

MPT combined with THSD can reduce the level of cytokines related to tissue repair.

The study provides a new comprehensive therapy for hyperplastic scar patients.

Butyrate could suppress IFN-γ-induced PD-L1 up-regulation in Colorectal Cancer (CRC) cells.

Butyrate promoted the lysine acetylation of STAT1 to reduce STAT1 expression.

Butyrate attenuated the IFN-γ-induced impairment of CD8+ T-cell cytotoxicity against CRC cells.

Butyrate suppressed CRC tumor growth by enhancing CD8+ T-cell infiltration.

It is able to as the balance point between the blood pressure and bleeding event.

It can reduce the bleeding amount and infusion volume and increase the cure rate of patients.

Restrictive fluid resuscitation has a promising value in the treatment of HTS, which is worthy of promotion in clinical practice.

KIF22 expression is upregulated in melanoma tissues and cells.

KIF22 knockdown suppresses proliferation and facilitates apoptosis of melanoma cells.

KIF22 knockdown inhibits tumor glycolysis in melanoma cells.

KIF22 depletion suppresses proliferation, glycolysis and facilitates apoptosis of melanoma cells by inactivating EGFR/STAT3 signaling.

HBO promoted a significant improvement in the clinical and histological statuses of the animals of this study experimental.

HBO is effective for the treatment of colitis by increasing the activity of antioxidant enzymes.

This study demonstrated a modulation of the immune response by reducing the expression of inflammatory cytokines and increasing the anti-inflammatory cytokines.

miR-143 is related with more inflammation and edema of intestinal loops of gastroschisis rat model.

Time of exposure of the amniotic fluid increases the intestinal damage.

miR-143 is a possible marker of gut inflammation.

Raloxifene effect on the CA1 hippocampus synaptic density.

Differences between early and late hormonal treatment on CA1 hippocampus synaptic density.

Estrogen action on the rat synaptic density is higher than one of raloxifene.

LFR can improve blood hemodynamics parameters after traumatic hemorrhagic shock.

LFR would influence serum inflammatory levels after traumatic hemorrhagic shock.

Medium MAP can be employed as the optimal administrating strategy for LFR.

• The role of diet in NAFLD development is still uncertain in PCOS women.

• Anthropometry and sedentarism were different between PCOS women with and without NAFLD.

• Food intake and dietary patterns were similar between PCOS women with and without NAFLD.

This meta-analysis shows that gefitinib plus chemotherapy showed significantly better efficacy in improving objective response rate, disease control rate, progression-free survival, and OS as compared with gefitinib alone.

Similar efficacy of gefitinib plus chemotherapy is found in the sub-population with positive EGFR mutation.

The toxicity of gefitinib plus chemotherapy is also increased but within clinical management.

There is no consensus about which method is preferred for biliary drainage for Perihilar Cholangiocarcinoma (PCCA).

Endoscopic retrograde cholangiopancreatography (EBD) or Percutaneous Transhepatic Biliary Drainage (PTBD) are options of choice.

PTBD is superior to EBD regarding crossover rate, overall post-drainage complications, and post-drainage pancreatitis.

EBD is superior to PTBD when it comes to hospital length of stay.

For the palliation of PCCA, PTBD is superior to EBD in terms of clinical success and post-drainage cholangitis.

Recently, cancer immunotherapy targeting PD-1 or PD-L1 has proven effective in causing durable antitumor immune responses with less toxicity in many types of tumors.

PD-1/PD-L1 blockade therapy will be the major cancer immunotherapy modality.

A deeper understanding of personal genomic information, and personalized markers in guiding anti-PD therapy.

Similar to the tip of an iceberg, PD-1/PD-L1 blockade antitumor immunotherapy opens a new era of cancer treatment, and further work on safety and efficiency will be required.

10 studies (1494 patients) were included in this systematic review.

LTx confers improved HRQoL in CF patients relative to their baseline state.

Up to 5-years post-LTx, CF patients’ HRQoL remains at the general population level.

Several factors modulate HRQoL outcomes in CF post-LTx.

HRQoL post-LTx in CF patients is either equal to or greater than other indications.

High quality of bowel cleansing is important to the accuracy of diagnosis and the safety of treatment in colonoscopy.

PEG combined with lactulose has a better efficacy in bowel preparation than PEG alone.

PEG combined with lactulose has fewer adverse reactions than PEG alone in bowel preparation.

Depression in Brazil.

Patient journey stages.

Awareness.

Colorectal Cancer (CRC) screening programs reduced the incidence and mortality of CRC.

CRC screening strategies were cost-effective or cost-saving, mainly in high-income countries.

There is a need to develop economic evaluation studies for CRC screening in low- and middle-income countries.

US-CNB is a reliable preoperative test for detecting axillary metastasis in breast cancer patients, with high accuracy and safety.

Compared to US-FNA, US-CNB shows even higher accuracy for detecting axillary metastasis in breast cancer patients.

The use of US-CNB as a preoperative test can reduce the need for a second operation and improve patient outcomes.

The prevalence of chronic pain in the adult population (35.70%) and older adults (47.32%).

Differs from region to region and is associated with heterogeneous risk factors.

Manifested mainly with moderate or severe intensity and with an elevated rate of disability.

None of the analized studies related serious adverse effects or toxicity to IV ASCs administration.

This review suggests optimism in IV ASCs for lung damage in severe COVID-19 ARDS.

Further studies on IV ASCs in COVID-19 are needed for standard dosage.

Improving the cellular environment is expected to further optimize the management of HF.

Metabolic remodeling is the driving force of deteriorated cellular environment in HF.

Targeting impaired energy provision is of great potential in the treatment of HF.

CT radiomics could preoperatively predict MVI in HCC with an AUC of 0.87.

Radiomics model based on 3D tumor segmentation, and deep learning model can be superior to predict MVI.

Reproducibility of current radiomics models for clinical application may be uncertain.

Deoxycholic acid is effective in submental fat reduction for both clinician and patient-related outcomes.

Well-tolerated side-effects were observed in Deoxycholic acid groups.

All eligible randomized trials showed a potential industry bias.

A meta-analysis was applied to analyze the performance of miRNA-29a in diagnosing active pulmonary tuberculosis.

miRNA-29a can be used as a biomarker for the diagnosis of active tuberculosis.

Tuberculosis burden and sample type of miRNA-29a may influence its diagnostic performance.

Bisphenola A (BPA) is an endocrine disruptor widely investigated as a possible environmental contributor to the pathogenesis of Polycystic Ovary Syndrome (PCOS).

Due to its structural similarity with the Estrogen molecule (E2), it acts as a xenoestrogen, binding to genomic and non-genomic estrogen receptors, causing metabolic and hormonal changes that lead to PCOS (hyperandrogenism, insulin resistance, hyperinsulinemia, obesity, atherogenic dyslipidemia, anovulation, and ovarian cysts).

The aim and of this review were to present the mechanisms of bisphenol A participation in the pathogenesis of Polycystic Ovary Syndrome.

Epigenetics, hypersensibility and asthma: what do we know so far?

Asthma can be triggered from epigenetic changes.

Early life exposures can contribute to the development and exacerbation of asthma.

DNA methylation profile of certain genes is related to asthma and allergy.

Nasal epithelium samples have shown promise as a tissue for studying DNA methylation changes related to asthma.

To find biomarkers and standardized assays to advance the field of epigenetics in respiratory disorders are still a challenge.

SARS-CoV-2 can temporarily reduce male fertility and alter sperm parameters.

Reversible menstrual disturbances happened after infection and vaccination.

IVF outcomes and laboratory parameters were not affected by SARS-CoV-2.

Homeopathy is based on heterodox and complementary four scientific assumptions.

Pseudosceptics deny these assumptions and any scientific evidence that proves them.

The dossier describes hundreds of clinical and experimental studies in homeopathy.

The dossier demystifies the fallacy that “there isn't scientific evidence for homeopathy”.