Homeopathy is based on four heterodox and complementary scientific assumptions.

Pseudoskeptics deny these assumptions and any scientific evidence that proves them.

The e-book proves the scientific evidence for homeopathy.

The e-book describes hundreds of experimental and clinical studies in homeopathy.

The e-book demystifies the fallacy that “homeopathy is placebo effect”.

Panoramic radiography is suitable for determining vertical bone loss around mini-implants.

Questionable implant sites are to be evaluated in cooperation with one other expert.

Unquantifiable implant sites are to be excluded regarding therapy decisions.

Mutual calibration sessions for bone level measurements are highly recommended.

circCPA4 deficiency inhibits PC3 cell metastasis.

circCPA4 interacts with miR-491-5p in affecting the biological behavior of PC3 cells.

circCPA4 mediates and affects the biological behavior of PC3.

Effects of AGEs in Parkinson's disease patients.

Recommendation healthy diet with a low AGE consumption.

Parkinson's disease patients’ lower strength and worsened functional capacity.

XBJ improves LPS-induced lung cell inflammation and pyroptosis.

miR-181d-5p inhibits LPS-induced inflammatory response and pyroptosis of lung epithelial cells.

XBJ elevates miR-181d-5p and improves LPS-induced pyroptosis of lung epithelial cells.

XBJ upregulates miR-181d-5p and inhibits SPP1 to protect lung epithelial cells from LPS-induced injuries.

CS-31 seems to be appropriate for use in oncology and may help to monitoring adverse effects and HRQL.

Tyrosine kinase domains with genomic alterations have oncogenic potential.

Higher efficacy for infigratinib than larotrectinib.

Infigratinib has a higher overall survival than larotrectinib.

Infigratinib has higher adverse effects than larotrectinib.

Bevacizumab initial therapy has a higher overall survival.

Correlation analysis of miR-141-5p and serum β-HCG, P4 and E2 levels in patients with ESA.

miR-141-5p as a diagnostic biomarker for ESA.

β-HCG, P4 and E2 levels.

DM1 is associated with changes in skeletal muscle functionality.

During pregnancy, the incidence of low back pain and pelvic pain is moderate and the presence of DM1 may be associated with the early appearance of this symptom.

The study demonstrated that pregnant women with DM1 complain of pain with a moderate incidence in the second trimester of pregnancy.

Factors such as length of illness are related to the higher frequency of pain in pregnant women with DM1.

Serum INSL-3 in patients with varicocele decreases with the severity of the disease.

Serum INSL-3 is positively correlated with total sperm count.

Serum InhB is associated with semen volume, concentration, and total sperm.

Serum InhB and INSL-3 levels could distinguish the degree of varicocele.

Few studies have examined outcomes after intrathoracic metastasectomy for nonseminomatous testicular germ cell tumors.

Integration of local and systemic therapies yields favorable outcomes with low morbidity and mortality.

Surgical management should be considered after chemotherapy, as histology prediction for metastatic lesions remains challenging.

This study highlights the importance of aggressive surgical approaches in improving long-term survival in young patients with testicular NSGCT.

3D laparoscopic surgery for early-stage EC seems to be more effective than traditional laparotomy.

3D laparoscopic surgery for early EC can attenuate the inflammatory response and damage to immune function, foster urinary function recovery, and enhance the quality of life.

3D laparoscopic surgery for early EC impacts the patient's coagulation function, necessitating vigilant prevention and management of thrombotic events in clinical settings.

Despite their importance, dignity and respect are woefully undefined, and often cast aside, which is reflected by the scarcity of in-depth studies.

Brazilian patients feel respected, but when it comes to consideration and integrity, it is nothing short of heartbreaking.

Brazilian health professionals do not ask their patients whom they would like to share information with. And this demands our utmost attention.

A sting of disrespect and affronts to our dignity seldom escape our notice.

The Scale of Perception of Respect for and Maintenance of the Dignity of the Inpatient sheds light on this aspect of human interaction.

COVID-19 profoundly affected global healthcare including breast cancer management.

The pandemic delayed recurrence diagnosis and increased post-recurrence mortality.

Strategies for cancer patients' follow-up during health crises need improvements.

Celiac disease and endometriosis share inflammatory markers and pathophysiology.

HLA-DQ2 and/or HLA-DQ8 were similar between the control and endometriosis groups.

Anti- transglutaminase igA was similar between the control and endometriosis groups.

HLA-DQ2 and DQ8 had no difference in age, symptoms, endometriosis stage or location.

CLD infants had delayed auditory conduction at more central brainstem regions.

Postnatal central auditory function is adversely affected by neonatal CLD.

Monitoring post-term auditory change is warranted for managing CLD infants after term.

To determine the prognostic value of perioperative hs-TnI in addition to traditional cardiac risk tools in patients undergoing elective major orthopedic surgery.

To evaluate the incidence of perioperative myocardial injury through systematic hs-TnI monitoring in a tertiary orthopedic center in Brazil.

Assessing mortality and cardiovascular complications in the short- and long-term periods after elective major orthopedic surgery.

Internal and external pessaries improved the quality of life of women with pelvic organ prolapse.

The use of an internal pessary changed the POP-Q stage related to prolapse of the anterior and apical vaginal compartments in women with pelvic organ prolapse.

Studies investigating alternative treatments for Pelvic organ prolapse, such as the use of an external pessary, are extremely important.

Visceral Pleural Invasion (VPI) in lung cancer is associated with skip N2 metastasis.

Nodal upstaging is linked to lymph-vascular invasion.

VPI impacts disease-free and overall survival rates.

Consideration of VPI in treatment decisions is crucial for improved patient outcomes.

Low HDL-C and high ferritin are linked to increased Long-COVID-19 severity.

Changes in HDL-C levels, significantly impact Long-COVID-19 progression.

Ferritin may exacerbate disease progression by increasing oxidative stress.

HDL-C and ferritin levels may serve as markers and therapeutic targets for Long-COVID-19.

Olanzapine is identified as a potentially effective prophylactic antiemetic.

Olanzapine reduces the incidence of postoperative nausea and vomiting.

Olanzapine has few side effects.

EUS-guided treatment for pancreatic cancer had fewer adverse reactions and a higher success rate.

The direct injection of absolute ethanol into the abdominal ganglion exerted the best pain relief effects.

US-guided Celiac Plexus Neurolysis (EUS-CPN) relieved and eliminated pain significantly.

Si-circABCA1 inhibits VMSC malignant proliferation, inflammation, and phenotypic switch.

miR-885–5p blocks the promoting effects of circABCA1 on VMSCs.

CircABCA1 regulates the miR-885–5p/ROCK2 axis in VMSCs.

Knockdown of circABCA1 reduces arterial plaque size and improves inflammation in AS mice.

Both polidocanol foam sclerotherapy and conventional surgery had positive impacts on patient quality of life.

Conventional surgery promotes greater improvement in patient quality-of-life than sclerotherapy.

Post-procedure pain and aesthetic concerns about the legs worsen the efficacy of sclerotherapy.

Surgical complications increase after the entry of new resident doctors.

Second-year resident doctors need more training time.

The increase in surgical complications is associated with the entry of new resident doctors, but also with the progression from the first to the second year of the course.

Obesity causes higher plasma OPN levels and higher expression of OPN in adipose tissue.

OPN and HGF are promising biomarkers that can be used to detect problems related to obesity.

Patients in the early post-SG period had lower plasma OPN and similar plasma HGF compared to nonsurgical patients.

After bariatric surgery, despite down-regulation of local OPN expression in adipose tissue, a significant increase in circulating OPN concentrations occurs

Government programs primarily focus on early childhood.

Primary Care services tend to be better for children under three years old.

New programs are needed to provide follow-up care for children beyond early childhood.

The prognostic model for pregnancy outcomes was constructed.

The prognostic factors included age, ANA, and anti-β2 glycoprotein I antibody levels.

The prognostic models showed higher value for predicting pregnancy success.

Higher FOXO3a levels suggest a link to malignancy in Uterine Smooth Muscle Tumors.

Elevated expression of FOXO3a is connected to LMS prognosis, indicating it is a survival marker.

MiRNA activity contributes to the imbalance of FOXO3a in Uterine Smooth Muscle Tumors.

This study establishes a strong correlation between the RAPID score and 3-month mortality in patients undergoing lung decortication for pleural empyema.

Patients were stratified into low, medium, and high-risk groups based on the RAPID score, demonstrating that this approach can be valuable in identifying patients with a higher likelihood of complications. This can inform treatment planning and post-operative monitoring.

While the results suggest a strong correlation, prospective studies are needed to fully validate the use of the RAPID score in this population. This underscores the importance of future clinical research to enhance the selection of the initial treatment for patients with pleural empyema.

MiR-1258 is downregulated in septic ALI.

MiR-1258 inhibits inflammation and oxidative stress via Pknox1 in ALI.

MiR-1258 targets Pknox1 to control TGF-β1/SMAD3 cascade.

The serum levels of sTREM-1 and IP-10 were increased in children with mycoplasma.

Serum levels of sTREM-1 and IP-10 were positively correlated with the severity of the disease.

sTREM-1 combined with IP-10 has an important value in the diagnosis of children with MPP.

Glutathione is important in protecting secondary spinal cord injury from oxidative stress.

As the secondary injury progresses, depletion in its reduced form occurs.

Using glutathione in traumatic spinal cord injury could help control the neurological injury.

In an experimental setting, the use of glutathione provided better functional scores after traumatic spinal cord injury.

TAN IIA inhibits IL-1β from inducing apoptosis and inflammation in CHON-001 cells.

FBXO11 overexpression inhibits the protective effect of TAN IIA on apoptosis and inflammation of CHON-001 cells.

Suppressing PI3K/AKT and NF-κB pathways protects against apoptosis and inflammation of CHON-001 cells.

TAN IIA treatment improves apoptosis and inflammation of chondrocytes in OA rats.

Analysis of clinical characteristics of subjects.

DKK3 levels are associated with END in patients with AIS.

DKK3 levels are associated with in-hospital death in patients with AIS.

ESK treatment can increase H9c2 cell viability and reduce apoptosis and intracellular Ca2+ concentration.

CAP treatment decreases H9c2 cell viability and increases apoptosis and intracellular Ca2+ concentration.

TRPV1 upregulation decreases H9c2 cell viability and increases cell apoptosis and intracellular Ca2+ concentration.

After overexpressing TRPV1, the protective effect of ESK on H/R injury of H9c2 cells is weakened.

PDZK1 is up-regulated in cancer tissues of HGG patients.

PDZK1 expression was significantly positively correlated with ktrans90, ve_90.

PDZK1 expression was negatively correlated with kep_max, kep_90.

Patients with high PDZK1 expression had poor OS and PFS.

PMAIP1 may be a potential biomarker for Alzheimer's Disease.

PMAIP1 has a certain pro-apoptotic effect.

PMAIP1 is participate in hippocampal neuron damage by regulating mitochondrial function.

The study developed an animal model of chronic intermittent hypoxia (CIH).

CIH activated oxidative stress (OS) inhearts, increased ROS, and up-regulated TRPC5.

TRPC5 is related to OS, the imbalance of Ca2+ homeostasis, and myocardial injury.

The prognosis of patients with SCLC can be predicted by their LN status.

The authors aimed to assess the correlations between SCLC survival and LNR, pLNs, LODDS.

LODDS may be better than other LN assessment tools at predicting survival in SCLC.

• Patient-doctor communication relates to patient satisfaction and perceived empathy.

• Patients asking questions was linked to poor satisfaction and empathy perceptions.

• Doctor's use of negative communication skills related to worse rapport with patients.

• Satisfaction and empathy are positively linked to patient affective expression.

• Doctors providing advice/suggestions positively correlated to patient satisfaction.

Blood transfusion significantly impacts long-term all-cause and cardiovascular mortality in the US population.

After propensity score-matching, the risk of all-cause mortality increased by 78 % with blood transfusion, and the risk of cardiovascular mortality increased by 102 %.

The effective management of blood transfusion in the general population may be beneficial.

Radiotherapy benefits prognosis in papillary renal cell carcinoma.

A precise nomogram predicts survival in pRCC patients.

External validation confirms the nomogram's applicability to Chinese pRCC.

Transient elastography is the best accepted noninvasive technique for evaluating fibrosis in patients with HCV.

The variation in the LSM measurement can demonstrate the risk of liver-related events.

The presence of LSM ≥19 kPa 6 months after treatment increases the risk of liver-related events.

Apatinib combined with TMZ is effective for recurrent GB.

Apatinib combined with TMZ can reduce the levels of sPD-1 and sPD-L1.

Role of the Keap1/Nrf2 pathway in epilepsy.

Effects of the Keap1/Nrf2 pathway on ferroptosis and oxidative stress in neuronal cells.

Effect of Keap1/Nrf2 pathway on neuronal cell activity in epileptic rats.

The authors created a new predictive model based on HALP scores in progressive NSCLC.

HALP score may be an accurate prognostic factor for PFS and OS in advanced NSCLC.

Balance impacts functional tasks in Parkinson's disease patients.

Specific treatment for balance deficits in Parkinson's disease patients.

BESTest × force platforms.

FeNO in bronchiolitis children was lower than that in healthy children.

Serum total IgE increased while FeNO decreased with the aggravation of bronchiolitis in bronchiolitis children.

Serum total IgE was higher in children with idiosyncratic bronchiolitis, but serum total IgEand FeNO were not the risk factors for idiosyncratic bronchiolitis.

Area Under the Curve (AUC) of serum total IgE and FeNO for the diagnosis of idiosyncratic bronchiolitis was less than 0.7.

Positive correlation between arthritis and hepatic steatosis, particularly in women.

No significant relationship between arthritis and the risk of liver fibrosis.

First study to examine the association between arthritis and both liver steatosis and fibrosis.

GH-IGFs-related parameters.

GH-IGFs-related parameters in patients with different severity of bronchial asthma.

Correlation analysis of GH-IGFs-related parameters and severity of bronchial asthma.

GH-IGFs-related parameters in patients with or without growth retardation.

Diagnostic value of GH-IGFs-related indicators in growth retardation.

Logistic regression analysis of GH-IGFs-related indicators and growth retardation.

When regional data were analyzed, it became clear that the worsening of blindness due to cataracts as a result of the pandemic was not avoided in the midwest region.

The assessment took place during a critical period of the COVID-19 pandemic; thus, the present study contributes to these findings and suggests that new epidemiological studies be carried out to monitor this worsening.

The larger the breast size, the longer the hospital stay and the higher the probability of infection.

Patients with a history of stroke had a higher incidence of infection.

The use of surgical support can improve quality of life.

Aerobic exercise strongly improved cardiac function and glucolipid metabolism in CHD.

Aerobic exercise enhanced IL-10 content, Bcl-2/Bax level as well as IB- expression in CHD.

Aerobic exercise reduced myocardial injury and cardiomyocyte apoptosis in CHD.

TE-CAP can predict steatosis with high accuracy.

For detecting ≥ S1 steatosis, TE-CAP has a sensitivity of 96 % and a specificity of 97 %.

For detecting ≥ S2 steatosis, TE-CAP has a sensitivity of 97 % and a specificity of 93 %.

For detecting ≥ S3 steatosis, TE-CAP has a sensitivity of 1 and a specificity of 94 %.

PCT was a highly sensitive marker to differentiate NICCD from cholestatic hepatitis patients.

PCT was reduced when NICCD was treated.

PCT is a much more effective marker to differentiate NICCD than the inflammatory markers.

• Tregs maintain self-tolerance and may allow the survival of ectopic endometrium.

• CD3+CD4+CD25High cells were similar between endometriosis and controls.

• CD3+CD4+CD25HighCD39+Foxp3+ cells were similar between endometriosis and controls.

• Foxp3+CD39+CD73+ Tregs are decreased in the blood of women with endometriosis.

• There is a decrease in systemic immune tolerance in patients with endometriosis.

HOXA11-AS silencing restrained HCOA cell proliferation and accelerated their apoptosis.

HOXA11-AS overexpression increased PIK3CA expression through binding to miR-506–3p.

HOXA11-AS overexpression represses PI3K/AKT/mTOR pathway through miR-506–3p down-regulation.

CircUBE2D2 subcellular localization and RNAse R resistance analysis.

Expression patterns of circUBE2D2 and miR-885-5p.

CircUBE2D2 silencing inhibits SKOV-3 cell malignant phenotypes.

CircUBE2D2 serves as the ceRNA of miR-885-5p.

Thoracentesis and chest tube insertions are frequent procedures in the medical routine.

Resident physician training includes practice in pleural procedures.

Point-of-care ultrasound is indicated when performing these procedures.

Using small-bore pigtail pleural catheters is safe and increasingly common.

Postural balance was reduced in higher BMI students.

BMI was correlated with postural balance but not functional mobility.

Body composition was correlated with postural balance but not functional mobility.

Exploring the factors that contribute to the disturbance of postural balance and functional mobility is recommended.

The frequency of prescription of medications not recommended for bronchiolitis is high.

Atopic phenotype did not interfere with the response to bronchodilators and glucocorticoids.

The lower the respiratory rate, the shorter the oxygen therapy duration for bronchiolitis.

PD-1/PDL-1′s comparison in cancer tissues and PPB of the remission with the non-remission.

Analysis of PD-1/PDL-1′s predictive value in cancer tissue and PPB on immunotherapy's efficacy.

Comparison of patients’ 3-year survival rate with PD-1/PDL-1 in diverse cancer tissues.

Exercise-based CR improved cardio-pulmonary function of patients receiving PCI.

Exercise-based CR improved hemodynamics parameters of patients receiving PCI.

IVR exercise showed much better effects than other strategies.

Melittin inhibits hypoxia-induced proliferation, glycolysis and angiogenesis in non-small cell lung cancer.

The activation of YAP/HIF-1α pathway promotes non-small cell lung cancer.

Melittin inactivates the YAP/HIF-1α pathway by up-regulating LATS2 expression.

Olfactory loss correlates with lower quality of life.

QOD is a reliable tool for olfactory assessment in Brazil.

QOD validation fills a crucial gap in Brazilian olfactory research.

circUSP9X reduction increases cell viability and decreases apoptosis and inflammation in HUVECs

SRCIN1: A Downstream Target of miR-148b-3p in DVT Pathogenesis.

SRC Kinase Signaling Inhibitor 1 (SRCIN1) is controlled by miR-148b-3p.

Sociodemographic, motor, visual and cognitive variables can predict the braking time.

In women muscle strength for predict the braking time.

In men cognitive conditions predict the braking time.

Cuproptosis-related genes are involved in acute myocardial infarction progression.

Dlat, Pdhb, and Pdhα1 levels were downregulated in acute myocardial infarction.

Dlat, Pdhb, and Pdhα1 may be diagnostic markers in acute myocardial infarction.

Pdhb showed the best diagnostic value for acute myocardial infarction.

Swimming training significantly prevented stress-induced corticosterone increase in rats.

Serum glucose, cholesterol and triglyceride were unchanged by chronic stress or exercise.

Chronic stress protocol induced glucose intolerance in the rats.

The training preserved the normal glycemic response after glucose loading in stressed rats.

Apoptosis is required for radiation sensitivity in HPV+ LSCC cells.

P53 and pRB are required for radiation sensitivity of HPV+ LSCC cells.

P53 and pRB are required for radiation sensitivity of HPV+ LSCC tumors in vivo.

Description of the rehabilitation of individuals with congenital malformations, with external fixator in aquatic therapy.

There is no association between diagnosis, type, and location of the external fixator, with the outcomes evaluated.

Aquatic therapy is a safe treatment option for the population studied.

There were linguistic tasks more preserved than others during the AD's progression.

Language is more globally affected in patients with less than 17 points on the MMSE.

The language profile can guide strategies to maintain communication.

The correlation between pancreatic islet α cell function and diabetic peripheral neuropathy

Gluca30min may be a potentially valuable independent predictor for the occurrence of DPN

To provide some reference for parenteral malignancy prevention in patients with IBD.

IBD was potentially associated with diffuse large B-cell lymphoma and skin cancers.

Some information on preventing parenteral malignancies in IBD was provided.

Further studies are needed to explore mechanisms of the effect of IBD on skin cancers.

Ezrin (EZR) is involved in oncogenesis and disease progression.

EZR is highly expressed in cervical squamous cell carcinoma and stomach adenocarcinoma.

NSC305787, an EZR inhibitor, reduces cell viability and clonal growth in cervical and gastric cancer cells.

EZR may be a molecular target in the treatment of cervical and gastric carcinoma.

EDTA clearance can be used to measure GFR in patients with solid tumors.

Precise GFR assessment is crucial to optimize therapy and minimize side effects.

There is a high agreement between two (46GFR) and three-time samples (246GFR).

Single-sample tests may be adopted for non-obese patients with expected normal GFR.

Knockdown of circAPP inhibits GIST proliferation and the Warburg effect.

miR-6838-5p induces GIST proliferation and the Warburg effect.

CircAPP activates GIST proliferation and the Warburg effect by regulating the miR-6838-5p/CDV3 axis.

ECV correlates with the response of the primary lesion to preoperative chemotherapy in abdominal neuroblastoma.

Lower ECV in neuroblastoma is associated with a greater reduction in primary lesion volume after chemotherapy.

ECV may serve as a new imaging biomarker for predicting chemotherapy efficacy in neuroblastoma.

PrEP has benefits beyond HIV prevention.

PrEP improves users’ quality of life.

PrEP improves self- satisfaction with sex life.

The levels of plasma exosomal miR-144-3p and miR-30b-5p are significantly decreased in RA patients, which are negatively correlated with RA disease activity.

Plasma exosomes from RA patients are pathogenic and may be involved in disease progression by enhancing B-cell differentiation and antibody production.

Plasma exosomal miR-144-3p and miR-30b-5p are potential serologic markers for RA.

The NHANES data was utilized in this study for conducting a comprehensive long-term follow-up analysis.

Deficiency of 25(OH)D was associated with an increased risk of all-cause mortality among patients with CKD.

Deficiency of 25(OH)D is associated with an increased risk of cardiovascular mortality in patients with CKD.

miR-181a-5p promotes fibroblast differentiation of BMSCs.

miR-181a-5p promotes fibroblast differentiation of BMSCs by targeting MFN1.

BMSCs containing miR-181a-5p improve PFD in SD rats by targeting MFN1 expression, thereby accelerating the fibroblast differentiation of BMSCs.

GO enrichment analysis include CC, BP and MF in diabetes.

Most significantly enriched pathways include thermogenesis, oxidative phosphorylation, and chemical carcinogenesis-reactive oxygen species.

The proportion of macrophages M2, CDB T-cells, monocytes, and resting mast cells (M2, T-cells CDB, Monocytes, Mast Cells resting) in samples from T2DM patients is higher and more abundant in diabetes.

The content of T-cells, testing NK cells, naive B-cells, and naive CD4 T-cells is relatively low in diabetes.

Patients with systemic lupus erythematosus have decreased functional and aerobic capacity and increased prevalence of cardiovascular diseases.

An unhealthy diet, characterized by a high consumption of ultraprocessed foods, as well as physical inactivity increase the cardiovascular risk factor.

58.6% of the patients exhibited high sedentary behavior (above 8h/day) and none of them meet with minimum physical activity recommendation.

Our sample reported a slightly higher consumption of ultraprocessed foods than that of the general population (20.0% vs. 18.4% of total energy value).

Relationship between bone mineral density and trabecular bone score.

Body fat percentage has negative relation with trabecular bone score.

Reallocation of lipids within muscle has a negative relationship with trabecular bone score.

In the case of 10 mg HNK treatment, compared with saline, the immobile time of compound C and D groups in the glass cylinder area was significantly different.

In the locomotor sensitization test, the movement distance of compound C and D groups on day 15 and day 7 mice increased significantly compared with the first day.

In the conditioned place preference experiment, compound C and compound D induced conditioned place preference in mice compared with the Veh group.

Spinal anesthesia combined with continuous epidural anesthesia has a better anesthesia effect in the painless labor of primiparas.

Spinal anesthesia combined with continuous epidural anesthesia can effectually ameliorate the labor process.

Spinal anesthesia combined with continuous epidural anesthesia attenuates the expression of serum estrogen and progesterone.

Spinal anesthesia combined with continuous epidural anesthesia can be widely employed in clinical practice.

100 % of the surgeons surveyed consider that improvements must be made in their work environment.

Direct appraisals from surgeons about the main components in an operating room can be a valuable source of information for future developments in the field.

Raise visibility in ergonomics, which may improve surgical conditions.

An inefficient transition process for children and adolescents with epilepsy may compromise adherence to consultations, and treatment and increase the hospitalization rate.

The “Readiness Checklists” were translated into Portuguese and applied to a group of patients and their respective caregivers in the transition process.

The lists can be very useful tools to assess and plan the follow-up of the population of patients with epilepsy in the process of transition.

The serum levels of IG % and D-D in the study and control group.

The serum levels of IG % and D-D in the survival group and death group.

Diagnostic value of IG % and D-D in severe pancreatitis.

Assessment value of IG % and D-D in prognosis of severe pancreatitis patients.

AMR measured after PCI can predict the risk of MACEs in patients with STEMI.

AMR-involved nomogram improved predictive performance over variables alone.

AAMR-involved nomogram-derived high-risk population showed a worse prognosis at 3 years.

AMR has the potential to be a feasible alternative for IMR.

Pue inhibits weight gain in atherosclerotic mice.

Pue inhibits serum lipid levels in atherosclerotic mice.

Pue inhibits inflammation in atherosclerotic mice.

Pue inhibits the formation of AS lesions.

This protocol describes a multicentre, randomized, placebo-controlled trial that aims to assess the efficacy and safety of specific stimulation mode SMES combined with NGF in reducing the recovery period of ischaemic stroke and provide evidence-based medical data.

This research will help provide the latest and high-quality evidence for clinicians and policymakers seeking innovative and effective ways to treat patients with ischaemic stroke.

Cunningham technique; sedation-free effective reduction.

Shorter hospital stays compared to those requiring procedural sedation for patients.

Can be applied outdoors, reducing delays in treatment and improving outcomes.

A nonlinear association between markers of oxidative stress and sarcopenia.

Alb was negatively correlated with the prevalence of sarcopenia.

The roughly L-curve association of total bilirubin and serum iron with sarcopenia.

Maintaining levels of oxidative stress markers is critical to preventing sarcopenia.

A prevalence of 8.3 % of drug-induced respiratory disorders was identified.

Triggers detected hospitalizations related to drug-induced respiratory disorders.

Four triggers showed good performance for detecting drug-induced respiratory disorder.

Two triggers detected therapeutic ineffectiveness related to respiratory symptoms.

In the present study, the authors found a new antiviral drug-azvudinea used in patients with hematological malignancies, is as effective and safe as the well-known nematve-litonavir.

There have been few clinical trials using azvudine to date, the present study may serve as a suggestion that the treatment was effective.

In the present study the authors found that anti-SARS-CoV-2 vaccines show significantly less robust efficacy in eliciting an immune response in HM patients than observed in the general population, suggesting that vaccination may be of little value in HM patients.

In the present study, the authors found a new antiviral drug-azvudinea used in patients with Hematological Malignancies (HM), is as effective and safe as the well-known nematve-litonavir.

Cardiovascular complications are common in the postoperative period of peripheral arterial vascular surgeries.

There is not a unique and standardized way to conduct preoperative evaluations in arterial vascular surgery patients.

In the studied hospital, in different time periods, evaluations were performed by either cardiologists or hospitalists.

Increased requests for exams had no impact on postoperative mortality or complications in this study.

Health managers should ensure appropriate utilization of human and financial resources for comparable outcomes.

To explore the relationship between AG, ACAG and in-hospital mortality of AMI.

Developing a prediction model for predicting the mortality in AMI patients.

Demonstrating good predicting performance for in-hospital mortality of AMI.

Preoperative music intervention effectively prevented hemodynamic instability during anesthesia induction in women undergoing elective non-cardiac surgery.

The overall preoperative anxiety incidence was 53.7 %, which was associated with a greater incidence of hemodynamic instability.

Preoperative music intervention significantly reduced preoperative anxiety.

The perinatal repercussions of the SARS-CoV-2 virus have not yet been elucidated.

Few reports in the literature indicate damage to the Neuro Psychomotor Development (NPMD) of children born during the COVID-19 pandemic, but its mechanisms are not clearly established.

A meta-analysis suggested that the risk for posterior-circulation stroke was roughly as high as the risk for anterior-circulation stroke. At the same time, the authors found that it was difficult to identify VBI upon routine physical examination with modalities such as carotid artery ultrasonography. The aim of this study was to investigate the possibility of FGF23 as a rapid biomarker for risk stratification of patients with acute CI and screen patients at high risk of CI.

The study assessed the characteristics of patients with CI and found that the severity of VBI was a significant factor. Furthermore, serum FGF23 levels were significantly higher in patients with CI and significantly associated with NIHSS score on the 7th day after diagnosis. It is suggested that serum FGF23 level at admission may be a predictor of short-term outcomes in patients with CI.

In the present study, FGF23 was a potential diagnostic indicator of CI with 79.8 % sensitivity and 80.3 % specificity. The ROC curve results indicated that serum FGF23 levels are a potential diagnostic biomarker for CI.

This study provides important insights into the potential clinical utility of FGF23 as a diagnostic biomarker for CI and VBI.

SNRT 1.092s. DC, DR, HR, SDNN, RMSSD value are lower after ablation.

AC, SSR, TH value were higher after ablation.

No complications occurred after ablation.

Left Atrial GP ablation has good long-term clinical results for bradyarrhythmia.

Respiratory symptoms common in the 2021 Gamma outbreak in pregnant women.

CVD caused poor outcomes in pregnant/postpartum women with COVID-19.

Gamma COVID-19 was most lethal for pregnant/postpartum women with CVD in Brazil.

This study underscores the Gamma variant's significant impact on maternal outcomes.

Oxycodone markedly induced the apoptosis of SKBR3 cells.

Oxycodone distinguished enhanced antitumor effect of PTX on SKBR3 cells.

OXY can enhance antitumor effect of PTX on breast cancer in vitro.

Serum Klotho, fetuin-A, and MGP were independent risk factors for CAC.

Serum Klotho, fetuin-A, and MGP were valuable in the diagnosis of CAC in MHD patients.

There is a close relationship between Klotho, fetuin-A, and MGP levels in MHD patients and CAC.

Gut Microbiota (GM) has an important role in liver diseases progression.

Notable differences in GM and diversity exist between healthy individuals and cirrhosis patients.

Changes in GM are associated with an increased risk of mortality within 90 days.

Firmicutes/Bacteroidetes and Firmicutes/Proteobacteria predict hepatic decompensation and mortality.

Retrospective review of hospitalized IAE cases in a large tertiary pediatric hospital (National Children's Regional Medical Center in China) which admits over 15000 pediatric patients every year.

Lower Glasgow coma score, longer duration of fever, with underlying medical conditions and complications pose a great risk to poor prognosis.

Children with IAE have high mortality rate. Influenza vaccination is Recommended to all eligible children.

The role of metabolism in Sjögren's Syndrome (SS) is still under discussion.

Saliva can reflect the metabolic state of the microenvironments of salivary glands affected by SS.

An increase in metabolites associated with oxidative stress can be observed.

An increase in metabolites involved in the growth and proliferation of T-cells was also observed.

TUSG aids post-op care, no radiation.

CXR limits: 2D, discomfort, radiation.

Study compares TUSG to CXR.

TUSG complements CXR, not a replacement.

Interval Debulking Surgery (IDS) treats ovarian cancer after neoadjuvant chemotherapy.

Relation between changes of C-reactive protein to Albumin Ratio (CAR) and IDS outcome.

CAR was an independent prognostic marker of optimal IDS for ovarian cancer patients.

Vestibulocochlear disorders can be caused by COVID-19 infection.

Sensorineural hearing loss can be present without clinical symptoms.

Electrophysiological tests suggest an abnormal auditory pathway after COVID-19.

The use of ototoxic drugs during COVID-19 can worsen hearing.

Pleural effusion is a common medical problem that occurs as a complication of many diseases.

The first thing that needs to be done is to decide whether the pleural fluid, obtained by thoracentesis, is a transudate or an exudate.

Attenuation measurements via thorax CT can be used to differentiate exudates from transudates.

Rectal cancer recurrence occurs predominantly in distant organs.

Local recurrence of rectal cancer could be predicted on restaging MRI.

Rectal cancer recurrence of patients treated with long course chemoradiation and total mesorectal excision is low and is associated with pathologic involvement of the radial surgical margin.

RaDID-QC was developed to screen dysphagia signs and symptoms.

RaDID-QC is meant to be applied to caregivers of older people with dementia.

RaDID-QC is a simple, concise, easy-to-apply, quick, and reliable questionnaire.

A simple and sensitive HPLC-DAD has been developed and validated for mitotone determination in plasma.

Plasma concentration of mitotane was assayed in adrenocortical cancer patients.

The assay is suitable for the therapeutic drug monitoring of mitotane in clinical settings.

Pathological characteristics of atrial fibrillation with cognitive impairment.

Correlation between cardiac function and degree of cognitive impairment.

Risk factors for cognitive impairment associated with atrial fibrillation.

In breast cancer from young women:

TP53 was affected in 75 % of TN samples, in concomitance with at least one additional driver gene, mainly NF1, NOTCH1 or PTPN13.

In TN tumors carrying a wild type TP53, other drivers were TSG, like ATR and NF1.

PIK3CA and GATA3 were the main cancer driver genes in luminal samples, and candidate drivers were GRHL2 and SMURF2.

CACNA1E is a candidate cancer driver in both luminal and TN samples.

Herpesviruses and various HPV genotypes are detectable in tumor samples and saliva of patients with orofacial tumors.

Prevalent genotypes were EBV (21.3 %), HPV-42 (29 %), HPV-43 (22.7 %), HPV-52 (22.2 %), HPV-39 (18.8 %), and HPV-18 (9.1 %).

Herpesvirus and HPV DNA were significantly more in the saliva of patients with orofacial tumors than in the control population.

Epstein Barr virus was more likely to be found in malignant tumor samples than benign orofacial tumors.

Pancreatic Adenocarcinoma (PAAD) exhibits a universally poor prognosis.

Tumor Immune Microenvironment (TIME) affected the development of tumor.

Immune Checkpoint-Related Genes (ICRGs) were associated with TIME formation.

ICRGs were associated with the prognosis of PAAD.

ICRGs may serve as novel clinical biomarkers and therapeutic targets.

NAC combined with AH is effective in treating pneumonia.

NAC combined with AH alleviates clinical symptoms of pneumonia.

NAC combined with AH reduces inflammatory response in pneumonia.

NAC combined with AH improves blood gas and immune function in pneumonia.

NAC combined with AH improves lung function in pneumonia.

Free breathing pulse gated non-enhanced rapid MR imaging can obtain images with diagnostic value.

Multi-plane and multi-angle thin-layer scanning are favorable for the display of the rupture, while some complex tears and bidirectional tears are poorly displayed.

Free breathing pulse gated non-enhanced rapid MR imaging technique can be used for the exclusive and definitive diagnosis of aortic dissection.

Non-enhancement peripheral pulse-gating rapid magnetic resonance imaging can be used for deterministic diagnosis of aortic dissection.

The impact of vitamin D3 supplementation on autoimmunity remains a subject of debate.

A single dose of 200,000 IU of vitamin D3 was not able to modulate autoantibodies in COVID-19 patients.

aPL antibody positivity was not associated with thrombotic events despite vitamin D3 supplementation.

aPL antibodies associated with the virus seem to be transient in critical patients.

During the COVID-19 pandemic, the prevalence of COVID-19 as the primary diagnosis for hospitalized patients with myocardial injury was 10 %.

•The mortality at 6 months was more than 40 % and independent predictors of death included age, peak troponin, and peak C-reactive protein levels.

Future studies should focus on targeting elevated oxidant stress and inflammatory biomarkers among these patients.

Postoperative HKAA in Oxford UKA had no correlation with the medial joint line change, the thickness of tibial resection and tibial implant.

Preoperative HKAA had a strong correlation with postoperative HKAA in Oxford UKA.

Preoperative smaller LDFA and larger MPTA had a moderate correlation with postoperative HKAA in Oxford UKA.

The observation group had higher HbA1c and fasting blood glucose levels. Poor blood glucose control and GWG are risk factors for PROM in GDM patients.

PROM increases adverse pregnancy outcomes in GDM.

HbA1c, insulin, and HOMA-IR can predict the risk of PROM in GDM.

The ADap, LADml, LADsi, LAVmax, LAVmin, LAVpre, LAPEF, LSPV CSA, LIPV CSA, RSPV CSA, RIPV CSA of AF patients were significantly higher.

There was a significant positive correlation between left atrial diameter and pulmonary vein structure.

There was a significant positive correlation between left atrial volume and pulmonary vein structure.

There was a negative correlation between left atrial active ejection fraction and pulmonary vein structure.

LADap, LADml, LADsi, LAVmax, LAVmin, LAVpre, LAPEF, LSPV CSA, LIPV CSA, RSPV CSA, RIPV CSA have diagnostic value for AF patients.

The IgE level is lower in female patients with AR compared with male patients.

AR patients’ IgE Level is affected by allergic history, home-raised plants, and pets.

IgE levels vary with furniture renewal, asthma, and age in allergic rhinitis patients.

TLR7/IL-23/IL-17 pathway activation in ARDS patients implicates immune dysregulation in disease severity.

TLR7/IL-23/IL-17 pathway is associated with adverse short-term prognosis in ARDS.

SP-D and CC-16 are positively correlated with TLR7/IL-23/IL-17 pathway activation, indicating lung injury involvement in ARDS progression.

Subtotal or Total Parathyroidectomy with autograft equally reduces the costs of medication in patients with secondary hyperparathyroidism in the long run.

Endocrine surgeons could individualize the operation technique in the treatment of hyperparathyroidism in dialysis patients.

The first month after parathyroidectomy shows an increased medication cost compared with the preoperative period in secondary hyperparathyroidism.

Clinicopathologic characteristics of patients.

Relationship between the degree of VI and serum HIF-1α, HIF-2α, YKL-40 and off-sTG levels.

Correlation analysis of serum HIF-1α, HIF-2α, and sYKL-40 with disease metastasis and recurrence in FTC patients.

Predictive assessment of serum HIF-1α, HIF-2α, and YKL-40 levels on the degree of VI and prognosis of FTC patients.

Fluconazole-resistant C. auris strain (CA01) identified in Beijing, belonging to South Asia Clade (I).

Molecular docking shows A395T mutation alters fluconazole binding in CA01. A395T mutation in ERG11 gene of CA01 linked to significant fluconazole resistance.

Identification of core virulence genes, including RBF1, in C. auris strain.

Adolescent particularities are not always considered for consultations at the ED.

Flu-like symptoms were the single main reason for adolescents to search for immediate health care.

Limb trauma was more common in younger and male teenagers.

Acute abdominal pain/trauma were the most frequent causes of hospital admissions.

There was a strong correlation between age and both admission rate and severity.

Fear of childbirth is more prevalent in patients with gestational diabetes mellitus.

Fear of Birth Scale score is higher in patients with gestational diabetes mellitus.

Reasons related to vaginal birth are more associated with clinically relevant fear.

Primary SRCC of the bladder has no specific clinical manifestations at early stage.

GATA3 serves as an independent protective factor for primary bladder SRCC.

Radical cystectomy is the treatment of choice for primary bladder SRCC.

Fluconazole pharmacokinetics is significantly altered in critically ill burn patients.

Half-life and total body clearance were correlated to volume of distribution decrease.

High-dose fluconazole may be necessary to guarantee coverage against Candida glabrata.

• •

  Children are at higher risk of developing atelectasis.

• •

  Imaging studies have increased specificity in the diagnosis of atelectasis.

• •

  The use of an ultrasound score can quantify pulmonary aeration.

Educational interventions to update healthcare professionals on the importance of CPAP.

Continuing education needs to be implemented for better patient care.

An educational intervention may have some success in educating and updating healthcare professionals on the use of CPAP in patients with chest tubes due to pleural effusion.

Physical therapists need to be strongly encouraged to write down the details of the interventions they perform in patients' medical records.

New strategies for continuing education of health professionals need to be developed so that the patient receives the best possible care.

The body fat of patients with kidney transplants was higher when compared to patients on hemodialysis and the control group.

Bone mineral content and bone mineral density were similar in hemodialysis patients and kidney transplant patients.

Body composition assessment in patients with chronic kidney disease could be an aid in their clinical control.

NAFLD is increasingly common in patients with chronic hepatitis B.

Neither NAFL nor NASH has an effect on the antiviral efficacy of chronic hepatitis B.

Viral load and degree of inflammation and fibrosis influence antiviral response.

Expression of mAChRs was elevated in the rat model of postoperative pain.

Antagonizing mAChRs reduced pain sensitivity and attenuated the IP3-Ca2+-CaM pathway.

Electroacupuncture further mitigated pain by suppressing IP3-Ca2+-CaM signaling.

Motor control actions are required to maintain semi-static balance and mobility.

Quadriceps and hamstring muscles are important for mobility.

Quadriceps and hamstring muscles are not important for semi-static balance.

IMP3, CDK4, MDM2 and β-catenin are expressed in Enchondromas of short bones.

These antibodies are useless in distinguishing Enchondroma and Chondrosarcoma G1.

Their positivity is proportional to Chondrosarcomas histological grade increase.

The positivity of IMP3, CDK4 and MDM2 is associated to metastasis.

The expression of MDM2 is associated with a worse prognosis related to death.

QL alleviates cardiomyocyte hypertrophy.

Silencing miR-382-5p could further enhance the therapeutic effect of QL.

miR-382-5p negatively regulates ATF3 expression.

ATF3 upregulation can reduce the hypertrophic effect of upregulation of miR-382-5p in NMVCs.

Surgical approach changes due to severe hyperplasia, obscure anatomic structure, etc.

A second surgery is due to nerve entrapment, nerve injury, lumbar instability, etc.

Appropriate indications and surgical approaches are chosen accordingly.

Knee osteoarthritis is a common joint disease.

Total Knee Arthroplasty (TKA) is the gold standard surgical treatment after failed conservative management.

There is a weak correlation between radiographic worsening and functional impairment in patients with knee osteoarthritis and indication for TKA.

MBV revision knee modular system (MBVS) could be a solution for complex scenarios.

In a mean follow up of 9.1 years, the MBVS showed 93.5 % of overall survivorship.

The MBV should not be used in cases with major instability.

The scarcity of publicly available computed tomography datasets with clinical details and four-phase segmentation masks hinders artificial intelligence research in hepatocellular carcinoma.

Developing an annotation platform in a teaching hospital necessitates integrating diverse technological tools and performing complex system integrations.

Successfully integrating an annotation platform and database for hepatocellular carcinoma can significantly enhance deep-learning research in this area.

Studies are inconclusive about the existence of a serum progesterone concentration correlated with higher clinical pregnancy rates in fresh embryo transfer after controlled ovarian stimulation cycles.

In fresh embryo transfer cycles, serum progesterone concentration may merely reflect factors associated with a favorable gestational prognosis rather than being a direct predictor of clinical pregnancy.

Caution is warranted when interpreting serum progesterone concentrations in fresh embryo transfer cycles, as there is no established cutoff point to justify additional exogenous progesterone supplementation for endometrial rescue or a freeze-all approach.

The chronic stage of spinal cord injury is the less studied group in animal models.

The biggest pool of patients with spinal cord injury are in a chronic stage.

Human umbilical cord and placental blood are highly available and can be used allogeneically.

Mice showed improved motor function after implantation of stem cells in the chronic stage.

Better function was achieved when stem cells were implanted near the subacute phase (3 weeks > 6 weeks).

In Brazil, breast cancer leads to 94,728 new cases and 22,189 deaths annually.

Early diagnosis and molecular profiles significantly impact breast cancer mortality.

Mammographic detection associated with lower prevalence of advanced-stage cancer.

Age, marital status, and race/color significantly influenced detection methods.

Luminal A tumors had the highest detection rates; triple-negative the lowest.

Understanding the impact of circadian rhythms on Parkinson's disease pathogenesis and mortality can revolutionize healthcare.

The authors investigated whether the deaths of Parkinson's disease patients follow a rhythmic pattern due to variations in the circadian rhythm.

During winter was seen more deaths, and fatalities peaked around 9 a.m.

Sunlight reduction increases mortality risk in the long term in patients with Parkinson's disease.

NLEs were associated with prevalent depression in men and women.

NLEs were associated to incident depression in women

Only financial hardship was associated to incident depression in men.

LIMITATIONS

NLEs questionnaire was self-reported with possible memory bias.

Depression was defined by validated scale but some misclassification is possible.

Chest wall tumors are rare conditions.

The literature has poorly documented the Chest wall reconstruction outcomes based on polypropylene mesh.

The postoperative evaluation resulted in a few cases of prostheses removal and a low respiration failure rate.

PEDF levels were lower and MMP-2 and TGF-β2 levels were higher in cataracts.

The combined detection was valuable in evaluating cataract development.

MMP-2, TGF-β2, and PEDF were risk factors for cataract development.

Psychiatric disorders can be associated with bariatric surgery, regardless of elapsed time.

Depression and anxiety were the most common conditions among operated patients.

Lifetime mood disorders, bipolar disorder, and eating disorders increase significantly in post-bariatric surgery.

Psychiatric disorders were not associated with recurrent weight gain over time.

Genetic analysis shows HDL mediates 7.3 % of BMI's impact on cholelithiasis risk.

Triglycerides contribute 3.5 % to BMI's effect on cholelithiasis, according to genetic evidence.

Targeting HDL & Triglycerides may reduce cholelithiasis risk in individuals with high BMI.

Study reveals novel insights into BMI-associated cholelithiasis mechanisms.

CEMIP silencing suppresses the proliferation, migration, invasion and ECM deposition of KF.

CEMIP binds to SPARC.

SPARC overexpression reversed the effects of CEMIP silencing on KF.

The TGF-β/Smad signaling was associated with the regulation of CEMIP SPARC in KF.

Substantial average of hospitalizations (4.3 per patient and 0.5 patient/year).

The main reasons for intestine transplantation were related to parenteral nutrition.

Complications related to parenteral nutrition were the main reason for hospitalization.

High burden of hospitalization and complication with a mean length of stay of 50 days.

Median time between SBS-IF diagnosis and transplant indication of 16 months.

The SERPINA1 gene encodes Alpha-1-Antitrypsin (A1AT), a protease inhibitor.

SERPINA1 gene polymorphisms are associated with ANCA-associated vasculitis.

Their presence represents poor prognostic factors in ANCA-associated vasculitis.

Congenital Diaphragmatic Hernia (CDH) is a congenital defect affecting 1 in every 5000 live births.

Sensorineural Hearing Loss (SNHL) is an important prevalent complication in survivors.

Mechanical ventilation and many other CDH therapies have been linked to SNHL.

Cochlear bleeding may be responsible and explain part of SNHL in CDH ventilated patients.

These findings reveal a stark difference in basic life support competencies between students in health-care related fields and those in non-health fields, emphasizing the need for universal basic life support training.

An action for curriculum modification to include basic life support training for all students is timely and practical, given the global burden of heart disease and the proven benefits of early intervention in sudden cardiac arrest cases.

This study contributes significantly to the ongoing discussion about health education and the role of non-health professionals in emergency medical response. It may serve as a catalyst for policy changes within educational institutions and among healthcare policymakers, aiming to create a more resilient and responsive community in the face of out-of-hospital medical emergencies.