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Journal Information
Issue
Vol. 79. (In progress)
(January - December 2024)
This issue is in progress but contains articles that are final and fully citable.
Editorials
It is time to change the definition: Endometriosis is no longer a pelvic disease
Maria Carolina Machado da Silva, Luiz Philipe de Souza Ferreira, Amanda Della Giustina
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Could immunotherapy be a hope for addiction treatment?
Maria Carolina Machado da Silva, Luiz Philipe de Souza Ferreira, Amanda Della Giustina
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It is time to spread the message of high-quality layperson cardiopulmonary resuscitation all over the world
Naomi Kondo Nakagawa, Andrew Lockey, Maria José Carvalho Carmona, Amber Hoover, Prama Nanda, Bernd Walter Böttiger
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Water pollution and the brain
Fulvio A. Scorza, Feres Chaddad-Neto, Larissa Beltramim, Josef Finsterer, Tomás de la Rosa
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Contextualizing stigma in Parkinson's disease research
Tomás de la Rosa, Fúlvio Alexandre Scorza
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Original articles
The intra- and inter-rater reproducibility of bone level measurements at strategic mini-implants using dental panoramic radiography
Martin Strauch, Ahmad Al Jaghsi, Christian Schwahn, Torsten Mundt
Highlights

  • Panoramic radiography is suitable for determining vertical bone loss around mini-implants.

  • Questionable implant sites are to be evaluated in cooperation with one other expert.

  • Unquantifiable implant sites are to be excluded regarding therapy decisions.

  • Mutual calibration sessions for bone level measurements are highly recommended.

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Development and internal validation of a clinical prediction model for spontaneous abortion risk in early pregnancy
Junqing Li, Jimei Yang, Min Lv, Xiang Wang, Zhijing Chen, Na Zhou, Xuetao Hou, Zhen Song
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circCPA4 induces malignant behaviors of prostate cancer via miR-491-5p/SHOC2 feedback loop
Wenqing Xu, Zhihong Zhong, Long Gu, Yiming Xiao, BinShen Chen, Weilie Hu
Highlights

  • circCPA4 deficiency inhibits PC3 cell metastasis.

  • circCPA4 interacts with miR-491-5p in affecting the biological behavior of PC3 cells.

  • circCPA4 mediates and affects the biological behavior of PC3.

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Advanced glycation end products consumption and the decline of functional capacity in patients with Parkinson's disease: Cross-sectional study
Jenifer Kristina Alves de Almeida, Guilherme Carlos Brech, Natália Mariana Silva Luna, Rodrigo Tallada Iborra, Jose Maria Soares-Junior, Edmund Chada Baracat, Júlia Maria D'Andrea Greve, Angélica Castilho Alonso, Adriana Machado-Lima
Highlights

  • Effects of AGEs in Parkinson's disease patients.

  • Recommendation healthy diet with a low AGE consumption.

  • Parkinson's disease patients’ lower strength and worsened functional capacity.

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Xuebijing improves inflammation and pyroptosis of acute lung injury by up-regulating miR-181d-5p-mediated SPP1 inactivation
XiaoYong Wu, RuoMei Xin, YanZhong Zhang, ChengRui Yang, FangYuan Sun, YanLiang Wang, FengXian Zheng
Highlights

  • XBJ improves LPS-induced lung cell inflammation and pyroptosis.

  • miR-181d-5p inhibits LPS-induced inflammatory response and pyroptosis of lung epithelial cells.

  • XBJ elevates miR-181d-5p and improves LPS-induced pyroptosis of lung epithelial cells.

  • XBJ upregulates miR-181d-5p and inhibits SPP1 to protect lung epithelial cells from LPS-induced injuries.

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Health-Related quality of life by 31-item Cervantes scale in breast cancer survivors undergoing adjuvant endocrine therapy
Isis Danyelle Dias Custódio, Fernanda Silva Mazzutti Nunes, Mariana Tavares Miranda Lima, Kamila Pires de Carvalho, Andressa Miranda Machado, Paula Philbert Lajolo, Carlos Eduardo Paiva, Yara Cristina de Paiva Maia
HIGHLIGHTS

  • CS-31 seems to be appropriate for use in oncology and may help to monitoring adverse effects and HRQL.

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Larotrectinib versus infigratinib for adult patients with both glioma and tyrosine kinase alterations after failure of initial therapies: Efficacy and safety analysis
Yufang Chen, Jian Ma, Qianqian Gao, Yu Gai, Yichi Sun, Meihua Wang
Highlights

  • Tyrosine kinase domains with genomic alterations have oncogenic potential.

  • Higher efficacy for infigratinib than larotrectinib.

  • Infigratinib has a higher overall survival than larotrectinib.

  • Infigratinib has higher adverse effects than larotrectinib.

  • Bevacizumab initial therapy has a higher overall survival.

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Expression and clinical significance of miR-141-5p as a biomarker in the serum of patients with early spontaneous abortion
XiaoQun Che, Xiao Wang, LiLian Wang, LiHua Xu, Lin Zou, TianZhong Ma, Bi Chen
Highlights

  • Correlation analysis of miR-141-5p and serum β-HCG, P4 and E2 levels in patients with ESA.

  • miR-141-5p as a diagnostic biomarker for ESA.

  • β-HCG, P4 and E2 levels.

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Low back pain, pelvic pain, and associated factors in type 1 diabetic pregnant women
Patricia Andrade Batista, Cláudia de Oliveira, Rafaela Alkmin da Costa, Rossana Pulcineli Vieira Francisco, Fabio Roberto Cabar
Highlights

  • DM1 is associated with changes in skeletal muscle functionality.

  • During pregnancy, the incidence of low back pain and pelvic pain is moderate and the presence of DM1 may be associated with the early appearance of this symptom.

  • The study demonstrated that pregnant women with DM1 complain of pain with a moderate incidence in the second trimester of pregnancy.

  • Factors such as length of illness are related to the higher frequency of pain in pregnant women with DM1.

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Relationship between semen parameters, serum InhB, and INSL-3 levels, and the degree of varicocele
Lei Liu, WenJie Huang, KeBing Luo, YiZhou Zeng, YunHao Shao, ZongMin Long
Highlights

  • Serum INSL-3 in patients with varicocele decreases with the severity of the disease.

  • Serum INSL-3 is positively correlated with total sperm count.

  • Serum InhB is associated with semen volume, concentration, and total sperm.

  • Serum InhB and INSL-3 levels could distinguish the degree of varicocele.

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National survey regarding obstetricians’ perspective of obstetric emergencies in Brazil
Vitória Espindola Leite Borges, Francisco Barbosa Jr, Fábio Fernandes Neves, Maria Rita de Souza Mesquita, Elaine Christine Dantas Moisés
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Prolonged survival after thoracic metastasectomy in patients with nonseminomatous testicular cancer
Jaqueline Schaparini Fonini, Pedro Henrique Xavier Nabuco de Araujo, Paula Duarte D'Ambrosio, Juliana Vieira de Oliveira Salerno, Pedro Prosperi Desenzi Ciaralo, Ricardo Mingarini Terra, Paulo Manuel Pêgo-Fernandes
Highlights

  • Few studies have examined outcomes after intrathoracic metastasectomy for nonseminomatous testicular germ cell tumors.

  • Integration of local and systemic therapies yields favorable outcomes with low morbidity and mortality.

  • Surgical management should be considered after chemotherapy, as histology prediction for metastatic lesions remains challenging.

  • This study highlights the importance of aggressive surgical approaches in improving long-term survival in young patients with testicular NSGCT.

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Effect of 3D laparoscopy versus traditional laparotomy on serum tumor markers and coagulation function in patients with early-stage endometrial cancer
Hailong Chen, Dechang Xu, Ying Yu, Jing Huang, Qian Zhou, Qi Wang
Highlights

  • 3D laparoscopic surgery for early-stage EC seems to be more effective than traditional laparotomy.

  • 3D laparoscopic surgery for early EC can attenuate the inflammatory response and damage to immune function, foster urinary function recovery, and enhance the quality of life.

  • 3D laparoscopic surgery for early EC impacts the patient's coagulation function, necessitating vigilant prevention and management of thrombotic events in clinical settings.

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Cross-cultural adaptation of the Scale of Perception of Respect for and Maintenance of the Dignity of the Inpatient (CuPDPH) to Brazilian Portuguese and its psychometric properties—A multicenter cross-sectional study
Pablo Eduardo Pereira Dutra, Laiana Azevedo Quagliato, Filipe Terra Curupaná, Letícia Zangirolami Peres, Victoria Luiza Pacini, Claudia Regina Menezes da Silva, Juliana Seixas Garcia, Beatriz Campillo Zaragoza, Antonio Egidio Nardi
Highlights

  • Despite their importance, dignity and respect are woefully undefined, and often cast aside, which is reflected by the scarcity of in-depth studies.

  • Brazilian patients feel respected, but when it comes to consideration and integrity, it is nothing short of heartbreaking.

  • Brazilian health professionals do not ask their patients whom they would like to share information with. And this demands our utmost attention.

  • A sting of disrespect and affronts to our dignity seldom escape our notice.

  • The Scale of Perception of Respect for and Maintenance of the Dignity of the Inpatient sheds light on this aspect of human interaction.

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Delayed diagnosis and increased mortality risk: Assessing the effects of the COVID-19 pandemic on breast cancer recurrence
Lindson Mühlmann, Franklin Fernandes Pimentel, Daniel Guimarães Tiezzi, Hélio Humberto Angotti Carrara, Jurandyr Moreira de Andrade, Francisco José Candido dos Reis
Highlights

  • COVID-19 profoundly affected global healthcare including breast cancer management.

  • The pandemic delayed recurrence diagnosis and increased post-recurrence mortality.

  • Strategies for cancer patients' follow-up during health crises need improvements.

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Evaluation of HLA-DQ2 and HLA-DQ8 haplotypes in patients with endometriosis, A case-control study
Marina P. Andres, Alessandra Peloggia, Henrique M. Abrao, Thais F. Magalhaes, João Siufi Neto, Mauricio Simões Abrão
Highlights

  • Celiac disease and endometriosis share inflammatory markers and pathophysiology.

  • HLA-DQ2 and/or HLA-DQ8 were similar between the control and endometriosis groups.

  • Anti- transglutaminase igA was similar between the control and endometriosis groups.

  • HLA-DQ2 and DQ8 had no difference in age, symptoms, endometriosis stage or location.

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Infants with neonatal Chronic Lung Disease are associated with delayed auditory conduction in the rostral brainstem after term
Ze Dong Jiang, Cui Wang, James K. Jiang, Jin Wang
Highlights

  • CLD infants had delayed auditory conduction at more central brainstem regions.

  • Postnatal central auditory function is adversely affected by neonatal CLD.

  • Monitoring post-term auditory change is warranted for managing CLD infants after term.

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Prognostic value of perioperative high sensitivity troponin in patients undergoing hip and knee arthroplasty
Fábio de Souza, Kelly Biancardini Gomes Barbato, Viviani Barreira Marangoni Ferreira, Danielle Menosi Gualandro, Bruno Caramelli
Highlights

  • To determine the prognostic value of perioperative hs-TnI in addition to traditional cardiac risk tools in patients undergoing elective major orthopedic surgery.

  • To evaluate the incidence of perioperative myocardial injury through systematic hs-TnI monitoring in a tertiary orthopedic center in Brazil.

  • Assessing mortality and cardiovascular complications in the short- and long-term periods after elective major orthopedic surgery.

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A randomized clinical trial comparing internal and external pessaries in the treatment of pelvic organ prolapse in postmenopausal women: A pilot study
Renato Sugahara Hosoume, Thais Villela Peterson, José Maria Soares Júnior, Edmund Chada Baracat, Jorge Milhem Haddad
Highlights

  • Internal and external pessaries improved the quality of life of women with pelvic organ prolapse.

  • The use of an internal pessary changed the POP-Q stage related to prolapse of the anterior and apical vaginal compartments in women with pelvic organ prolapse.

  • Studies investigating alternative treatments for Pelvic organ prolapse, such as the use of an external pessary, are extremely important.

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The association of visceral pleural invasion with skip N2 metastasis on clinical stage IA NSCLC
Fabio Minamoto, Pedro Araújo, Paula D'Ambrosio, Alberto Dela Vega, Leticia Lauricella, Paulo Pêgo-Fernandes, Ricardo Terra
Highlights

  • Visceral Pleural Invasion (VPI) in lung cancer is associated with skip N2 metastasis.

  • Nodal upstaging is linked to lymph-vascular invasion.

  • VPI impacts disease-free and overall survival rates.

  • Consideration of VPI in treatment decisions is crucial for improved patient outcomes.

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Reduced HDL-cholesterol in long COVID-19: A key metabolic risk factor tied to disease severity
Jamila Al-Zadjali, Amal Al-Lawati, Nafila Al Riyami, Koukab Al Farsi, Najwa Al Jarradi, Ammar Boudaka, Ali Al Barhoumi, Mohsen Al Lawati, ... Jumana Saleh
Highlights

  • Low HDL-C and high ferritin are linked to increased Long-COVID-19 severity.

  • Changes in HDL-C levels, significantly impact Long-COVID-19 progression.

  • Ferritin may exacerbate disease progression by increasing oxidative stress.

  • HDL-C and ferritin levels may serve as markers and therapeutic targets for Long-COVID-19.

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Olanzapine as a prophylactic antiemetic for preventing postoperative nausea and vomiting after general anesthesia: A systematic review and meta-analysis
Thiago Ramos Grigio, Hans Timmerman, Angela Maria Sousa, André Paul Wolff
Highlights

  • Olanzapine is identified as a potentially effective prophylactic antiemetic.

  • Olanzapine reduces the incidence of postoperative nausea and vomiting.

  • Olanzapine has few side effects.

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A meta-analysis on the efficacy of endoscopic ultrasonography for treatment of pancreatic cancer
Min Xuan, Na Li, Chunyan Wu
Highlights

  • EUS-guided treatment for pancreatic cancer had fewer adverse reactions and a higher success rate.

  • The direct injection of absolute ethanol into the abdominal ganglion exerted the best pain relief effects.

  • US-guided Celiac Plexus Neurolysis (EUS-CPN) relieved and eliminated pain significantly.

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Circ-ABCA1 promotes oxidized low-density lipoprotein-induced inflammation and phenotypic switch in vascular smooth muscle cells
Fang Yu, JiWei Liu, Xiao Wei
Highlights

  • Si-circABCA1 inhibits VMSC malignant proliferation, inflammation, and phenotypic switch.

  • miR-885–5p blocks the promoting effects of circABCA1 on VMSCs.

  • CircABCA1 regulates the miR-885–5p/ROCK2 axis in VMSCs.

  • Knockdown of circABCA1 reduces arterial plaque size and improves inflammation in AS mice.

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Polidocanol-foam treatment of varicose veins: Quality-of-life impact compared to conventional surgery
Lissa Severo Sakugawa, Felipe Soares Oliveira Portela, Andressa Cristina Sposato Louzada, Maria Fernanda Cassino Portugal, Marcelo Passos Teivelis, Cynthia de Almeida Mendes, Lucas Lembrança Pinheiro, Marcelo Fiorelli Alexandrino da Silva, ... Nelson Wolosker
Highlights

  • Both polidocanol foam sclerotherapy and conventional surgery had positive impacts on patient quality of life.

  • Conventional surgery promotes greater improvement in patient quality-of-life than sclerotherapy.

  • Post-procedure pain and aesthetic concerns about the legs worsen the efficacy of sclerotherapy.

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Surgical complications in the first and second semesters of the general surgery medical residence. A study of 14063 cases
Bruno Henrique Alvarenga, Izabel Cristina Rios, Francisco de Salles Collet e Silva, Edivaldo Massazo Utiyama
Highlights

  • Surgical complications increase after the entry of new resident doctors.

  • Second-year resident doctors need more training time.

  • The increase in surgical complications is associated with the entry of new resident doctors, but also with the progression from the first to the second year of the course.

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Patients who received sleeve gastrectomy have lower plasma osteopontin levels than those who did not
Doğan Öztürk, Arzu Or Koca, Müge Keskin, Bülent Öztürk, Esra Fırat Oğuz, Turan Turhan, Hakan Buluş
Highlights

  • Obesity causes higher plasma OPN levels and higher expression of OPN in adipose tissue.

  • OPN and HGF are promising biomarkers that can be used to detect problems related to obesity.

  • Patients in the early post-SG period had lower plasma OPN and similar plasma HGF compared to nonsurgical patients.

  • After bariatric surgery, despite down-regulation of local OPN expression in adipose tissue, a significant increase in circulating OPN concentrations occurs

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Comparative analysis of primary health care attributes between children under and over 3 years of age using the primary care assessment tool
Luciana Harumi Miranda Omori, Deoclecio Avigo, Itamar de Souza Santos, Gustavo Diniz Ferreira Gusso, Maria Teresa Bechere Fernandes
Highlights

  • Government programs primarily focus on early childhood.

  • Primary Care services tend to be better for children under three years old.

  • New programs are needed to provide follow-up care for children beyond early childhood.

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Prognostic model on pregnancy outcomes for women with recurrent spontaneous abortions treated with cyclosporin A: A single-institution experience
Ze-Ming Zhang, Na Zhang, Xiao-Fei Wang
Highlights

  • The prognostic model for pregnancy outcomes was constructed.

  • The prognostic factors included age, ANA, and anti-β2 glycoprotein I antibody levels.

  • The prognostic models showed higher value for predicting pregnancy success.

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FOXO3a deregulation in uterine smooth muscle tumors
Thais Gomes de Almeida, Anamaria Ritti Ricci, Laura Gonzalez dos Anjos, Jose Maria Soares Junior, Gustavo Arantes Rosa Maciel, Edmund Chada Baracat, Katia Candido Carvalho
Highlights

  • Higher FOXO3a levels suggest a link to malignancy in Uterine Smooth Muscle Tumors.

  • Elevated expression of FOXO3a is connected to LMS prognosis, indicating it is a survival marker.

  • MiRNA activity contributes to the imbalance of FOXO3a in Uterine Smooth Muscle Tumors.

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Evaluation of the RAPID score as a predictor of postoperative morbidity and mortality in patients undergoing pulmonary decortication for stage III pleural empyema
Danilo Caribé Carneiro, Paula Duarte D'Ambrosio, Alessandro Wasum Mariani, Jaqueline Schaparini Fonini, Gabriela Ketherine Zurita Aguirre, João Pedro Carneiro Leão, Aurelino Fernandes Schmidt Júnior, Eihab O. Bedawi, ... Paulo Manuel Pêgo-Fernandes
Highlights

  • This study establishes a strong correlation between the RAPID score and 3-month mortality in patients undergoing lung decortication for pleural empyema.

  • Patients were stratified into low, medium, and high-risk groups based on the RAPID score, demonstrating that this approach can be valuable in identifying patients with a higher likelihood of complications. This can inform treatment planning and post-operative monitoring.

  • While the results suggest a strong correlation, prospective studies are needed to fully validate the use of the RAPID score in this population. This underscores the importance of future clinical research to enhance the selection of the initial treatment for patients with pleural empyema.

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MicroRNA-1258 suppresses oxidative stress and inflammation in septic acute lung injury through the Pknox1-regulated TGF-β1/SMAD3 cascade
XiaoMeng Xu, XiaoHong Xu, JinLiang Cao, LuoYang Ruan
Highlights

  • MiR-1258 is downregulated in septic ALI.

  • MiR-1258 inhibits inflammation and oxidative stress via Pknox1 in ALI.

  • MiR-1258 targets Pknox1 to control TGF-β1/SMAD3 cascade.

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Diagnostic values of soluble triggering receptor expressed on myeloid cells (sTREM-1) and interferon-inducible protein-10 (IP-10) for severe mycoplasma pneumoniae pneumonia in children
Chang Xu, Li-Yan Luo, Bi-Chen Wu, Niu Ding, Shi-Jie Jin, Jian-Bao Huang, Yan-Ping Chen
Highlights

  • The serum levels of sTREM-1 and IP-10 were increased in children with mycoplasma.

  • Serum levels of sTREM-1 and IP-10 were positively correlated with the severity of the disease.

  • sTREM-1 combined with IP-10 has an important value in the diagnosis of children with MPP.

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Glutathione effect on functional and histological recovery after spinal cord injury in rats
Fernando Flores de Araujo, Raphael Martus Marcon, Alexandre Fogaça Cristante, Tarcísio Eloy Pessoa Barros Filho
Highlights

  • Glutathione is important in protecting secondary spinal cord injury from oxidative stress.

  • As the secondary injury progresses, depletion in its reduced form occurs.

  • Using glutathione in traumatic spinal cord injury could help control the neurological injury.

  • In an experimental setting, the use of glutathione provided better functional scores after traumatic spinal cord injury.

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Tanshinone IIA alleviates IL-1β-induced chondrocyte apoptosis and inflammation by regulating FBXO11 expression
Jin Xu, XiaoCheng Zhi, YunHui Zhang, Ren Ding
Highlights

  • TAN IIA inhibits IL-1β from inducing apoptosis and inflammation in CHON-001 cells.

  • FBXO11 overexpression inhibits the protective effect of TAN IIA on apoptosis and inflammation of CHON-001 cells.

  • Suppressing PI3K/AKT and NF-κB pathways protects against apoptosis and inflammation of CHON-001 cells.

  • TAN IIA treatment improves apoptosis and inflammation of chondrocytes in OA rats.

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Predictive value of glycoprotein DKK3 for early neurological deterioration after ischemic stroke
DongLiang Zhou, HongWei Qin, Lei Miao, Ying Xu, Lan Yu, JianMin Wang
Highlights

  • Analysis of clinical characteristics of subjects.

  • DKK3 levels are associated with END in patients with AIS.

  • DKK3 levels are associated with in-hospital death in patients with AIS.

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Esketamine alleviates hypoxia/reoxygenation injury of cardiomyocytes by regulating TRPV1 expression and inhibiting intracellular Ca2+ concentration
Ying Zhang, QuanMei Lu, HanChun Hu, ChunChen Yang, QiHong Zhao
Highlights

  • ESK treatment can increase H9c2 cell viability and reduce apoptosis and intracellular Ca2+ concentration.

  • CAP treatment decreases H9c2 cell viability and increases apoptosis and intracellular Ca2+ concentration.

  • TRPV1 upregulation decreases H9c2 cell viability and increases cell apoptosis and intracellular Ca2+ concentration.

  • After overexpressing TRPV1, the protective effect of ESK on H/R injury of H9c2 cells is weakened.

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PDZK1 is correlated with DCE-MRI perfusion parameters in high-grade glioma
Yi Zhang, Feng Wang, YongLi Huang
Highlights

  • PDZK1 is up-regulated in cancer tissues of HGG patients.

  • PDZK1 expression was significantly positively correlated with ktrans90, ve_90.

  • PDZK1 expression was negatively correlated with kep_max, kep_90.

  • Patients with high PDZK1 expression had poor OS and PFS.

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The mechanism of mitochondrial metabolic gene PMAIP1 involved in Alzheimer's disease process based on bioinformatics analysis and experimental validation
Yingchun Ling, Lingmin Hu, Jie Chen, Mingyong Zhao, Xinyang Dai
Highlights

  • PMAIP1 may be a potential biomarker for Alzheimer's Disease.

  • PMAIP1 has a certain pro-apoptotic effect.

  • PMAIP1 is participate in hippocampal neuron damage by regulating mitochondrial function.

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TRPC5 channel participates in myocardial injury in chronic intermittent hypoxia
Mengmeng Wang, Wen Wen, Yulan Chen, Sharezati Yishajiang, Yu Li, Zhiqiang Li, Xiangyang Zhang
Highlights

  • The study developed an animal model of chronic intermittent hypoxia (CIH).

  • CIH activated oxidative stress (OS) inhearts, increased ROS, and up-regulated TRPC5.

  • TRPC5 is related to OS, the imbalance of Ca2+ homeostasis, and myocardial injury.

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Association of log odds of positive lymph nodes with survival in patients with small cell lung cancer: Results from the SEER database
Ting Gao, Yingxuan Chang, Hongmei Yue
Highlights

  • The prognosis of patients with SCLC can be predicted by their LN status.

  • The authors aimed to assess the correlations between SCLC survival and LNR, pLNs, LODDS.

  • LODDS may be better than other LN assessment tools at predicting survival in SCLC.

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Physicians’ attention to patients’ communication cues can improve patient satisfaction with care and perception of physicians’ empathy
Carlos Frederico Confort Campos, Clarice Rosa Olivo, Milton de Arruda Martins, Patricia Zen Tempski
Highlights

  • • Patient-doctor communication relates to patient satisfaction and perceived empathy.

  • • Patients asking questions was linked to poor satisfaction and empathy perceptions.

  • • Doctor's use of negative communication skills related to worse rapport with patients.

  • • Satisfaction and empathy are positively linked to patient affective expression.

  • • Doctors providing advice/suggestions positively correlated to patient satisfaction.

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Blood transfusion is correlated with elevated adult all-cause mortality and cardiovascular mortality in the United States: NHANES 1999 to 2018 population-based matched propensity score study
Jie Shi, Min Meng, Rina Sa, Lijun Yu, Yali Lu, Bei Gao
Highlights

  • Blood transfusion significantly impacts long-term all-cause and cardiovascular mortality in the US population.

  • After propensity score-matching, the risk of all-cause mortality increased by 78 % with blood transfusion, and the risk of cardiovascular mortality increased by 102 %.

  • The effective management of blood transfusion in the general population may be beneficial.

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Development and validation of prognostic nomograms for adult with papillary renal cell carcinoma: A retrospective study
Qingxiang Guo, Sai Li, Jiawei Zhu, Zewei Wang, Zhen Li, Junqi Wang, Rumin Wen, Hailong Li
Highlights

  • Radiotherapy benefits prognosis in papillary renal cell carcinoma.

  • A precise nomogram predicts survival in pRCC patients.

  • External validation confirms the nomogram's applicability to Chinese pRCC.

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Noninvasive assessment of liver fibrosis can predict clinical outcomes at late follow-up after a sustained virological response in HCV patients?
Taisa Grotta Ragazzo, Patricia Momoyo Yoshimura Zitelli, Daniel F. Mazo, Claudia P. Oliveira, Flait José Carrilho, Mário Guimarães Pessoa
Highlights

  • Transient elastography is the best accepted noninvasive technique for evaluating fibrosis in patients with HCV.

  • The variation in the LSM measurement can demonstrate the risk of liver-related events.

  • The presence of LSM ≥19 kPa 6 months after treatment increases the risk of liver-related events.

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Effects of Apatinib combined with Temozolomide on levels of sPD-1 and sPD-L1 in patients with drug-resistant recurrent glioblastoma
Ren Zhao Kuang, Jun Wang, Yuan Chuan Wang, Xiao Ping Tang
Highlights

  • Apatinib combined with TMZ is effective for recurrent GB.

  • Apatinib combined with TMZ can reduce the levels of sPD-1 and sPD-L1.

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Keap1/Nrf2 signaling pathway participating in the progression of epilepsy via regulation of oxidative stress and ferroptosis in neurons
Dandan Wang, Yunmei Cui, Fan Gao, Weiwei Zheng, Jinzi Li, Zhemin Xian
Highlights

  • Role of the Keap1/Nrf2 pathway in epilepsy.

  • Effects of the Keap1/Nrf2 pathway on ferroptosis and oxidative stress in neuronal cells.

  • Effect of Keap1/Nrf2 pathway on neuronal cell activity in epileptic rats.

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Prognostic nomogram based on pre-treatment HALP score for patients with advanced non-small cell lung cancer
Shan Gao, Qin Huang, Suosu Wei, Yanru Lv, Yanyan Xie, Yanrong Hao
Highlights

  • The authors created a new predictive model based on HALP scores in progressive NSCLC.

  • HALP score may be an accurate prognostic factor for PFS and OS in advanced NSCLC.

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The decline in postural balance has a negative impact on the performance of functional tasks in individuals with Parkinson's Disease
Natália Mariana Silva Luna, Tatiana Godoy Bobbio, Myriam de Graaf, Júlia Maria D'Andrea Greve, Rita de Cássia Ernandes, Aluane Silva Dias, Matheus Henrique dos Santos Lino, Jose Maria Soares-Junior, ... Angelica Castilho Alonso
Highlights

  • Balance impacts functional tasks in Parkinson's disease patients.

  • Specific treatment for balance deficits in Parkinson's disease patients.

  • BESTest × force platforms.

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Correlation analysis between serum total IgE and FeNO and idiosyncratic reaction in bronchiolitis
XiaoYing Xu, WeiNing Han, WeiPing Han
Highlights

  • FeNO in bronchiolitis children was lower than that in healthy children.

  • Serum total IgE increased while FeNO decreased with the aggravation of bronchiolitis in bronchiolitis children.

  • Serum total IgE was higher in children with idiosyncratic bronchiolitis, but serum total IgEand FeNO were not the risk factors for idiosyncratic bronchiolitis.

  • Area Under the Curve (AUC) of serum total IgE and FeNO for the diagnosis of idiosyncratic bronchiolitis was less than 0.7.

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Association between hepatic steatosis and fibrosis and arthritis among US adults: A population-based study
Zhiming Lu, Shaojie Wu, Eryou Feng, Xiaoli Chen, Jinhua Chen, Feitai Lin
Highlights

  • Positive correlation between arthritis and hepatic steatosis, particularly in women.

  • No significant relationship between arthritis and the risk of liver fibrosis.

  • First study to examine the association between arthritis and both liver steatosis and fibrosis.

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Changes of GH-IGFs and its relationship with growth retardation in children with bronchial asthma
Li Li, Lihua Qiu, Junchao Xia, Yichun Xiao, Li Zhao, Haiyan Wang
Highlights

  • GH-IGFs-related parameters.

  • GH-IGFs-related parameters in patients with different severity of bronchial asthma.

  • Correlation analysis of GH-IGFs-related parameters and severity of bronchial asthma.

  • GH-IGFs-related parameters in patients with or without growth retardation.

  • Diagnostic value of GH-IGFs-related indicators in growth retardation.

  • Logistic regression analysis of GH-IGFs-related indicators and growth retardation.

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Impact of the COVID-19 pandemic on cataract surgeries in Brazil: A retrospective study
Silvana Rossi, Rafael Scherer, Priscilla Jorge, Newton Kara-Junior
Highlights

  • When regional data were analyzed, it became clear that the worsening of blindness due to cataracts as a result of the pandemic was not avoided in the midwest region.

  • The assessment took place during a critical period of the COVID-19 pandemic; thus, the present study contributes to these findings and suggests that new epidemiological studies be carried out to monitor this worsening.

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Benefits of using a support bra in women undergoing coronary artery bypass graft surgery: A randomized trial
Thais Rodrigues de Almeida Silva, Julia Nishida Ono, Fabiana Cristina Bazana Remedio Miname, Luís Henrique Wolff Gowdak, Bruno Maher Mioto, Renan Barbosa dos Santos, Luiz Roberto Palma Dallan, Luiz Antonio Machado Cesar
Highlights

  • The larger the breast size, the longer the hospital stay and the higher the probability of infection.

  • Patients with a history of stroke had a higher incidence of infection.

  • The use of surgical support can improve quality of life.

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Effects of aerobic exercise on myocardial injury, NF-B expression, glucolipid metabolism and inflammatory factors in rats with coronary heart disease
Shaowu Zhang, Guohui Yu, Maohua Ping, Qing Du, Xia Guo
Highlights

  • Aerobic exercise strongly improved cardiac function and glucolipid metabolism in CHD.

  • Aerobic exercise enhanced IL-10 content, Bcl-2/Bax level as well as IB- expression in CHD.

  • Aerobic exercise reduced myocardial injury and cardiomyocyte apoptosis in CHD.

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Clinical research of fibroscan ‒ TE-CAP at noninvasive diagnosis of hepatic steatosis in children
Shuangzhen Jia, Jianli Zhou, Qiao Zhang, Shaoming Zhou, Zhaoxia Wang, Xiaolin Ye, Jie Wu
Highlights

  • TE-CAP can predict steatosis with high accuracy.

  • For detecting ≥ S1 steatosis, TE-CAP has a sensitivity of 96 % and a specificity of 97 %.

  • For detecting ≥ S2 steatosis, TE-CAP has a sensitivity of 97 % and a specificity of 93 %.

  • For detecting ≥ S3 steatosis, TE-CAP has a sensitivity of 1 and a specificity of 94 %.

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Serum procalcitonin as a marker of neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD)
Tao Jiang, Wen-Xian Ouyang, Yan-Fang Tan, Ying Yu, Xiao-Mei Qin, Hai-Yan Luo, Lian Tang, Hui Zhang, Shuang-Jie Li
Highlights

  • PCT was a highly sensitive marker to differentiate NICCD from cholestatic hepatitis patients.

  • PCT was reduced when NICCD was treated.

  • PCT is a much more effective marker to differentiate NICCD than the inflammatory markers.

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Foxp3+CD39+CD73+ regulatory T-cells are decreased in the peripheral blood of women with deep infiltrating endometriosis
Luiza Gama Coelho Riccio, Marina Paula Andres, Isabella Zurita Dehó, Giovanna Ometto Fontanari, Maurício Simões Abrão
Highlights

  • • Tregs maintain self-tolerance and may allow the survival of ectopic endometrium.

  • • CD3+CD4+CD25High cells were similar between endometriosis and controls.

  • • CD3+CD4+CD25HighCD39+Foxp3+ cells were similar between endometriosis and controls.

  • • Foxp3+CD39+CD73+ Tregs are decreased in the blood of women with endometriosis.

  • • There is a decrease in systemic immune tolerance in patients with endometriosis.

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Down-regulation of long noncoding RNA HOXA11-AS nullifies the impact of microRNA-506–3p on chondrocytes proliferation and apoptosis in osteoarthritis
Ziyang Zhang, Renhao Guo, Chengfa Cai, Pengcheng Guo
Highlights

  • HOXA11-AS silencing restrained HCOA cell proliferation and accelerated their apoptosis.

  • HOXA11-AS overexpression increased PIK3CA expression through binding to miR-506–3p.

  • HOXA11-AS overexpression represses PI3K/AKT/mTOR pathway through miR-506–3p down-regulation.

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CircUBE2D2 regulates HMGB1 through miR-885-5p to promote ovarian cancer malignancy
RuiXue Yan, SaiTian Zeng, FangYuan Gao, LingLing Li, XiYun Xiao
Highlights

  • CircUBE2D2 subcellular localization and RNAse R resistance analysis.

  • Expression patterns of circUBE2D2 and miR-885-5p.

  • CircUBE2D2 silencing inhibits SKOV-3 cell malignant phenotypes.

  • CircUBE2D2 serves as the ceRNA of miR-885-5p.

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Resident physician training in bedside pleural procedures: A one-year experience at a teaching hospital
Diego Arley Gomes da Silva, Paula Duarte D'Ambrosio, Fabio Eiti Nishibe Minamoto, Bernardo Mulinari de Lacerda Pessoa, Eserval Rocha Junior, Leticia Leone Lauricella, Ricardo Mingarini Terra, Paulo Manuel Pêgo-Fernandes, Alessandro Wasum Mariani
Highlights

  • Thoracentesis and chest tube insertions are frequent procedures in the medical routine.

  • Resident physician training includes practice in pleural procedures.

  • Point-of-care ultrasound is indicated when performing these procedures.

  • Using small-bore pigtail pleural catheters is safe and increasingly common.

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Postural balance and functional mobility in relation to BMI and body composition among female students at a College of Applied Medical Sciences: A cross-sectional study
Muneera Mohammed Almurdi
Highlights

  • Postural balance was reduced in higher BMI students.

  • BMI was correlated with postural balance but not functional mobility.

  • Body composition was correlated with postural balance but not functional mobility.

  • Exploring the factors that contribute to the disturbance of postural balance and functional mobility is recommended.

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Acute viral bronchiolitis phenotype in response to glucocorticoid and bronchodilator treatment
Andressa Roberta Paschoarelli Chacorowski, Vanessa de Oliveira Lima, Eniuce Menezes, Jorge Juarez Vieira Teixeira, Dennis Armando Bertolini
Highlights

  • The frequency of prescription of medications not recommended for bronchiolitis is high.

  • Atopic phenotype did not interfere with the response to bronchodilators and glucocorticoids.

  • The lower the respiratory rate, the shorter the oxygen therapy duration for bronchiolitis.

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Analysis of PD-1/PD-L1 variations in lung cancer and association with immunotherapeutic efficacy and prognosis: A nonrandomized controlled trial
Jun Ma, JianRui Song, LiNa Han, Wen Zhou, LiFeng Meng, JianHui Li, XiaoMing Bai
Highlights

  • PD-1/PDL-1′s comparison in cancer tissues and PPB of the remission with the non-remission.

  • Analysis of PD-1/PDL-1′s predictive value in cancer tissue and PPB on immunotherapy's efficacy.

  • Comparison of patients’ 3-year survival rate with PD-1/PDL-1 in diverse cancer tissues.

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Effects of different early cardiac rehabilitation exercise treatments on the prognosis of acute myocardial infarction patients receiving percutaneous coronary intervention
Huiying Liang, Xinhua Hu, Hongying Liao
Highlights

  • Exercise-based CR improved cardio-pulmonary function of patients receiving PCI.

  • Exercise-based CR improved hemodynamics parameters of patients receiving PCI.

  • IVR exercise showed much better effects than other strategies.

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Melittin inactivates YAP/HIF-1α pathway via up-regulation of LATS2 to inhibit hypoxia-induced proliferation, glycolysis and angiogenesis in NSCLC
Hao Li
Highlights

  • Melittin inhibits hypoxia-induced proliferation, glycolysis and angiogenesis in non-small cell lung cancer.

  • The activation of YAP/HIF-1α pathway promotes non-small cell lung cancer.

  • Melittin inactivates the YAP/HIF-1α pathway by up-regulating LATS2 expression.

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Validation of the questionnaire of olfactory disorders (QOD) for the Brazilian population
Amanda Beatriz Costa da Silva Bernardino, Márcio Andrade Barreto-Filho, Amanda Savieto Pompeu, Jaqueline dos Santos Andrade, Amanda Canário Andrade Azevedo, Michelle Queiroz Aguiar Brasil, Mariana Cedro, Cintia Araújo, ... Marco Aurélio Fornazieri
Highlights

  • Olfactory loss correlates with lower quality of life.

  • QOD is a reliable tool for olfactory assessment in Brazil.

  • QOD validation fills a crucial gap in Brazilian olfactory research.

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Circ-USP9X accelerates deep vein thrombosis after fracture by acting as a miR-148b-3p sponge and upregulates SRC kinase signaling inhibitor 1
YongChao Wang, Qin Su, HaiRong Tang, Xin Lin, YanHua Yi, Qiang Tian, ZhangFeng Luo, MeiChun Fu, ... KeYun Zhang
Highlights

  • circUSP9X reduction increases cell viability and decreases apoptosis and inflammation in HUVECs

  • SRCIN1: A Downstream Target of miR-148b-3p in DVT Pathogenesis.

  • SRC Kinase Signaling Inhibitor 1 (SRCIN1) is controlled by miR-148b-3p.

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Multifactorial assessment of braking time predictors in a driving simulator among older adults according to gender
Maria Eugenia Mayr De Biase, Angelica Castilho Alonso, Reinaldo Nonato da Silva, Sara Moutinho Soares, Alexandra Carolina Canonica, Alessandra Pricila dos Reis Belini, Jose Maria Soares-Junior, Edmund Chada Baracat, ... Júlia Maria D'Andrea Greve
Highlights

  • Sociodemographic, motor, visual and cognitive variables can predict the braking time.

  • In women muscle strength for predict the braking time.

  • In men cognitive conditions predict the braking time.

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Identification of potential crucial cuproptosis-related genes in myocardial ischemia-reperfusion injury through the bioinformatic analysis
Rong Huang, Rongfeng Xu, Rui Zhang, Wenjie Zuo, Zhenjun Ji, Zaixiao Tao, Yongjun Li, Genshan Ma
Highlights

  • Cuproptosis-related genes are involved in acute myocardial infarction progression.

  • Dlat, Pdhb, and Pdhα1 levels were downregulated in acute myocardial infarction.

  • Dlat, Pdhb, and Pdhα1 may be diagnostic markers in acute myocardial infarction.

  • Pdhb showed the best diagnostic value for acute myocardial infarction.

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Effects of physical training on the metabolic profile of rats exposed to chronic restraint stress
Carlos H.O. Reis, Sabriny G. Manzolli, Leonardo dos Santos, Ariana A. Silva, Ana Paula Lima-Leopoldo, André S. Leopoldo, Danilo S. Bocalini
Highlights

  • Swimming training significantly prevented stress-induced corticosterone increase in rats.

  • Serum glucose, cholesterol and triglyceride were unchanged by chronic stress or exercise.

  • Chronic stress protocol induced glucose intolerance in the rats.

  • The training preserved the normal glycemic response after glucose loading in stressed rats.

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P53 and pRB induction improves response to radiation therapy in HPV-positive laryngeal squamous cell carcinoma
Weiquan Ding, Weiwei Cai, Haili Wang
Highlights

  • Apoptosis is required for radiation sensitivity in HPV+ LSCC cells.

  • P53 and pRB are required for radiation sensitivity of HPV+ LSCC cells.

  • P53 and pRB are required for radiation sensitivity of HPV+ LSCC tumors in vivo.

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Aquatic therapy in congenital malformation during the use of external fixator for bone lengthening: It is possible?
Caio Roberto Aparecido de Paschoal Castro, Alessandra Mitie Kakihata, Carla Borges Fleuri de Barros, Monica Gonçalves, Beatriz Carvalho de Souza, Larissa Soares da Silva, Douglas Martins Braga
Highlights

  • Description of the rehabilitation of individuals with congenital malformations, with external fixator in aquatic therapy.

  • There is no association between diagnosis, type, and location of the external fixator, with the outcomes evaluated.

  • Aquatic therapy is a safe treatment option for the population studied.

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Language impairments in Alzheimer´s disease: What changes can be found between mild and moderate stages of the disease?
Karin Zazo Ortiz, Juliana Onofre De Lira, Thais Soares Ciariancullo Minett, Paulo Henrique Ferreira Bertolucci
Highlights

  • There were linguistic tasks more preserved than others during the AD's progression.

  • Language is more globally affected in patients with less than 17 points on the MMSE.

  • The language profile can guide strategies to maintain communication.

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Correlation between islet α cell function and peripheral neuropathy in patients with type 2 diabetes mellitus
Yurou Cao, Xueqin Wang
Highlights

  • The correlation between pancreatic islet α cell function and diabetic peripheral neuropathy

  • Gluca30min may be a potentially valuable independent predictor for the occurrence of DPN

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Association between inflammatory bowel disease and the risk of parenteral malignancies: A two-sample Mendelian randomization study
Peizhu Su, Yilin Wang, Huiwen Huang, Qinghua Lu, Qinyan Wu, Zhaotao Li
Highlights

  • To provide some reference for parenteral malignancy prevention in patients with IBD.

  • IBD was potentially associated with diffuse large B-cell lymphoma and skin cancers.

  • Some information on preventing parenteral malignancies in IBD was provided.

  • Further studies are needed to explore mechanisms of the effect of IBD on skin cancers.

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Transcriptomics analysis identified ezrin as a potential druggable target in cervical and gastric cancer cells
Maria Fernanda Lopes Carvalho, Carolina Santana Calicchio, Bruna Oliveira de Almeida, Livia Bassani Lins de Miranda, Jean Carlos Lipreri da Silva, Keli Lima, João Agostinho Machado-Neto
HIGHLIGHTS

  • Ezrin (EZR) is involved in oncogenesis and disease progression.

  • EZR is highly expressed in cervical squamous cell carcinoma and stomach adenocarcinoma.

  • NSC305787, an EZR inhibitor, reduces cell viability and clonal growth in cervical and gastric cancer cells.

  • EZR may be a molecular target in the treatment of cervical and gastric carcinoma.

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Comparison of plasma clearance of [51Cr]CrEDTA based on three, two and single samples to measure the glomerular filtration rate in patients with solid tumors: a prospective cross-sectional analysis
Anne C. Gomes, George B. Coura Filho, Luiz A. Gil Junior, Renato A. Caires, Emmanuel A. Burdmann, Carlos A. Buchpiguel, Veronica T. Costa e Silva, Marcelo T. Sapienza
Highlights

  • EDTA clearance can be used to measure GFR in patients with solid tumors.

  • Precise GFR assessment is crucial to optimize therapy and minimize side effects.

  • There is a high agreement between two (46GFR) and three-time samples (246GFR).

  • Single-sample tests may be adopted for non-obese patients with expected normal GFR.

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CircRNA amyloid precursor protein by competitive adsorption of microRNA-6838-5p mediates CDV3 expression to enhance malignant behavior and Warburg effect in Gastrointestinal Stromal Tumor
Zhaorigetu  , ChunJuan Wang, XianJing Zeng, JinHua Yuan
Highlights

  • Knockdown of circAPP inhibits GIST proliferation and the Warburg effect.

  • miR-6838-5p induces GIST proliferation and the Warburg effect.

  • CircAPP activates GIST proliferation and the Warburg effect by regulating the miR-6838-5p/CDV3 axis.

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Impact of pre-treatment extracellular volume fraction measured by computed tomography on response of primary lesion to preoperative chemotherapy in abdominal neuroblastoma
Haoru Wang, Xin Chen, Mingye Xie, Jinjie Qin, Ting Li, Ling He
Highlights

  • ECV correlates with the response of the primary lesion to preoperative chemotherapy in abdominal neuroblastoma.

  • Lower ECV in neuroblastoma is associated with a greater reduction in primary lesion volume after chemotherapy.

  • ECV may serve as a new imaging biomarker for predicting chemotherapy efficacy in neuroblastoma.

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Impact of HIV pre-exposure prophylaxis (PREP) on health-related quality of life (QOL) of patients followed up at a reference center in São Paulo, Brazil
Michelle Kaoru Takada-de-Souza, Camila de Melo Picone, Vivian Iida Avelino-Silva, Angela Carvalho Freitas, Aluisio Cotrim Segurado
Highlights

  • PrEP has benefits beyond HIV prevention.

  • PrEP improves users’ quality of life.

  • PrEP improves self- satisfaction with sex life.

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Characterization of the MicroRNA profile in rheumatoid arthritis plasma exosomes and their roles in B-cell responses
Jian Lu, Jing Wu, Xiao Zhang, Rui Zhong, BingYing Wang, Huan Yang, Ping Feng
Highlights

  • The levels of plasma exosomal miR-144-3p and miR-30b-5p are significantly decreased in RA patients, which are negatively correlated with RA disease activity.

  • Plasma exosomes from RA patients are pathogenic and may be involved in disease progression by enhancing B-cell differentiation and antibody production.

  • Plasma exosomal miR-144-3p and miR-30b-5p are potential serologic markers for RA.

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Association of serum 25-hydroxyvitamin D with cardiovascular and all-cause mortality in patients with chronic kidney disease: NHANES 2007‒2018 results
Luohua Li, Jinhan Zhao
Highlights

  • The NHANES data was utilized in this study for conducting a comprehensive long-term follow-up analysis.

  • Deficiency of 25(OH)D was associated with an increased risk of all-cause mortality among patients with CKD.

  • Deficiency of 25(OH)D is associated with an increased risk of cardiovascular mortality in patients with CKD.

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microRNA-181a-5p promotes fibroblast differentiation of mesenchymal stem cells in rats with pelvic floor dysfunction
YongHong Zhang, HaiYang Yu, JianChao Li
Highlights

  • miR-181a-5p promotes fibroblast differentiation of BMSCs.

  • miR-181a-5p promotes fibroblast differentiation of BMSCs by targeting MFN1.

  • BMSCs containing miR-181a-5p improve PFD in SD rats by targeting MFN1 expression, thereby accelerating the fibroblast differentiation of BMSCs.

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Food consumption, physical activity and aerobic capacity in systemic lupus erythematosus patients with high cardiovascular risk
Fabiana Infante Smaira, Bruna Caruso Mazzolani, Sofia Mendes Sieczkowska, Marina Romero, Thainá Toledo Ribeiro, Milla Cordeiro Amarante, Sandra Pasoto, Ana Lúcia de Sá Pinto, ... Bruno Gualano
Highlights

  • Patients with systemic lupus erythematosus have decreased functional and aerobic capacity and increased prevalence of cardiovascular diseases.

  • An unhealthy diet, characterized by a high consumption of ultraprocessed foods, as well as physical inactivity increase the cardiovascular risk factor.

  • 58.6% of the patients exhibited high sedentary behavior (above 8h/day) and none of them meet with minimum physical activity recommendation.

  • Our sample reported a slightly higher consumption of ultraprocessed foods than that of the general population (20.0% vs. 18.4% of total energy value).

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Ectopic fat in muscle and poor glycemic control are negatively associated with trabecular bone score in type 2 diabetes
Iana Mizumukai de Araújo, Carlos Ernesto Garrido Salmon, Francisco José Albuquerque de Paula
Highlights

  • Relationship between bone mineral density and trabecular bone score.

  • Body fat percentage has negative relation with trabecular bone score.

  • Reallocation of lipids within muscle has a negative relationship with trabecular bone score.

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Study on the antidepressant activity of (2R,6R; 2S,6S)-Hydroxynorketamine (HNK) and its derivatives
Dongdong Zang, Xuemei Yang, Hao Wang, Zhenxing Li, Yanjun Ma, Jianxi Liu, Xi Mei, Shupeng Li, ... Zhen Tan
Highlights

  • In the case of 10 mg HNK treatment, compared with saline, the immobile time of compound C and D groups in the glass cylinder area was significantly different.

  • In the locomotor sensitization test, the movement distance of compound C and D groups on day 15 and day 7 mice increased significantly compared with the first day.

  • In the conditioned place preference experiment, compound C and compound D induced conditioned place preference in mice compared with the Veh group.

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Effects of different anesthesia methods on labor process and postpartum serum estrogen and progesterone levels in primiparas with painless labor
JunYan Liu, ChongLai Shi, Dan Wang, XiaoDong Cui, LiLi Geng, JingJing Cui, DongMei Sun, Zhuo Yin
Highlights

  • Spinal anesthesia combined with continuous epidural anesthesia has a better anesthesia effect in the painless labor of primiparas.

  • Spinal anesthesia combined with continuous epidural anesthesia can effectually ameliorate the labor process.

  • Spinal anesthesia combined with continuous epidural anesthesia attenuates the expression of serum estrogen and progesterone.

  • Spinal anesthesia combined with continuous epidural anesthesia can be widely employed in clinical practice.

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Ergonomics appraisals in operating rooms
Jaime Solleiro Rodríguez, Juan Antonio Juanes Méndez, Fernando Blaya Haro
Highlights

  • 100 % of the surgeons surveyed consider that improvements must be made in their work environment.

  • Direct appraisals from surgeons about the main components in an operating room can be a valuable source of information for future developments in the field.

  • Raise visibility in ergonomics, which may improve surgical conditions.

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The value of immature granulocyte percentage united with D-Dimer in the evaluation of severe pancreatitis and its prognosis
Tian-Tian Xu, Si-Bing Chen
Highlights

  • The serum levels of IG % and D-D in the study and control group.

  • The serum levels of IG % and D-D in the survival group and death group.

  • Diagnostic value of IG % and D-D in severe pancreatitis.

  • Assessment value of IG % and D-D in prognosis of severe pancreatitis patients.

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Review articles
Gastric adenocarcinoma and periodontal disease: A systematic review and meta-analysis
Francisco José Nunes Aguiar, Fabrício dos Santos Menezes, Marcela de Araújo Fagundes, Gisele Aparecida Fernandes, Fabio de Abreu Alves, João Goncalves Filho, Maria Paula Curado
Highlights

  • Patients presenting periodontal disease increased the risk of developing gastric adenocarcinoma by 17 %.

  • The association remained regardless of the diagnostic method for periodontal disease, i.e., clinical examination and self-report.

  • Moreover, Asian patients with periodontal disease had a higher risk of having gastric adenocarcinoma than American and European patients.

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Multidisciplinary team for patients with neurocutaneous syndromes: The little discussed importance of dentistry
Marcos Roberto Tovani-Palone, Filippo Bistagnino, Pritik A. Shah
Highlights

  • The inclusion of dentists in multidisciplinary teams for patients with neurocutaneous syndromes is essential, both on an outpatient and hospital basis.

  • Interestingly, dentistry can play a relevant role in the early diagnosis and differential diagnosis of patients with neurocutaneous syndromes.

  • More research in this area is needed.

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Pharmacological treatment for obstructive sleep apnea: A systematic review and meta-analysis
Maria Luísa Nobre, Ayane Cristine Alves Sarmento, Priscila Farias de Oliveira, Felipe Ferreira Wanderley, José Diniz Júnior, Ana Katherine Gonçalves
Highlights

  • Obstructive sleep apnea affects one billion people worldwide and is associated with cardiometabolic risk and cognitive impairment.

  • Drug therapy for the management of sleep apnea has been investigated, but no robust evidence that supports its benefits has been found to date.

  • The combination of noradrenergic and antimuscarinic drugs shows promising results.

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Impulse oscillometry in patients with pulmonary arterial hypertension: an exploratory study
Helena Jannuzzi Villas Bôas, Ilma Aparecida Paschoal, Mônica Corso Pereira
Highlights

  • Impulse Oscillometry (IOS) can be used to analyze lung resistance and reactance in patients with PAH.

  • Patients with PAH show increased resistance and pulmonary reactance compared to healthy individuals.

  • The IOS findings showed a good correlation with the spirometric variables.

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Screening and diagnostic tools for autism spectrum disorder: Systematic review and meta-analysis
Clara Lucato dos Santos, Indyanara Inacio Barreto, Idevaldo Floriano, Luca Schiliró Tristão, Antonio Silvinato, Wanderley Marques Bernardo
Highlights

  • Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder.

  • Autism spectrum disorder has a significant impact on the patient and their family.

  • To provide adequate advice is to carry out screening and diagnosis correctly and accurately.

  • Screening test must be applied, M-CHAT-R/F is recommended.

  • For diagnosis CARS and ADOS are the most recommended tools.

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Effect of photobiomodulation therapy on pain perception during anesthetic puncture of dental local anesthesia: A systematic review
Caio Melo Mesquita, Millena Barroso Oliveira, Marcelo Dias Moreira de Assis Costa, Walbert Andrade Vieira, Rafael Rodrigues Lima, Sigmar de Mello Rode, Luiz Renato Paranhos
Highlights

  • Photobiomodulation therapy seems to have little or no effect on pain perception during the anesthetic puncture in patients undergoing dental local anesthesia.

  • Clinical trials found in the literature used different study samples, pain assessment tools, and photobiomodulation therapy protocols.

  • Further randomized studies should be performed with a standardized methodology to strengthen the current evidence.

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Low-level red-light therapy for myopia control in children: A systematic review and meta-analysis
Dillan Cunha Amaral, Sávio Batista, Edson dos Santos-Neto, José Eduardo Ferreira Manso, Márcio Penha Morterá Rodrigues, Mário Luiz Ribeiro Monteiro, Milton Ruiz Alves, Ricardo Noguera Louzada
Highlights

  • There is a global increase in childhood myopia and current treatments are limited.

  • LLRL non-invasive therapy shows promise in myopia control.

  • LLRL is promising and requires further studies for standardization and safety.

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Visceral crisis in metastatic breast cancer: an old concept with new perspectives
Matheus de Oliveira Andrade, Renata Rodrigues da Cunha Colombo Bonadio, Maria Del Pilar Estevez Diz, Laura Testa
Highlights

  • Visceral crisis in metastatic breast cancer is associated with a dismal prognosis.

  • There is a lack of objective clinical criteria in the definition of visceral crisis.

  • Visceral crisis management is currently based on limited retrospective evidence and expert opinions.

  • The role of chemotherapy as the treatment of choice for visceral crisis has been recently questioned.

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Is religiosity/spirituality in patients with Crohn's disease important to their quality of life?
José Luiz Amuratti Gonçalves, José Jukemura, Carolina Bortolozzo Graciolli Facanali, Carlos Frederico Sparapan Marques, Rodrigo Ambar Filho, Carlos Walter Sobrado, Sergio Carlos Nahas
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Real-world setting comparison of bridging therapy versus direct mechanical thrombectomy for acute ischemic stroke: A meta-analysis
Bin Qin, Tao Wei, Wen Gao, Hui-xun Qin, Yu-Ming Liang, Cheng Qin, Hong Chen, Ming-Xiu Yang
Highlights

  • Acute ischaemic stroke is becoming a major public health concern.

  • The nationwide or health organization registry databases were included.

  • Bridging therapy remains the standard treatment until more data are available.

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The effects of art therapy interventions on anxiety in children and adolescents: A meta-analysis
Bo Zhang, Jiahua Wang, Azizah binti Abdullah
Highlights

  • This meta-analysis aimed to evaluate the impact of art therapy on reducing anxiety symptoms among children and adolescents. A comprehensive search was conducted across several databases, including PubMed, Web of Science, Embase, PsychINFO, The Cochrane Library, CNKI, and Wan Fang Data, resulting in the inclusion of six studies with a total of 422 participants. The findings demonstrated a significant decrease in anxiety symptoms through art therapy interventions, with a Standardized Mean Difference (SMD) of -1.42, 95% Confidence Interval (-2.33, -0.51), p < 0.002. This indicates that art therapy is an effective method for treating anxiety in this demographic. Moreover, the analysis revealed that art therapy had a more pronounced effect on state anxiety than on trait anxiety, suggesting that art therapy may be particularly beneficial in helping children and adolescents manage anxiety in specific situations. These insights underscore the importance of integrating art therapy into mental health care, especially for managing anxiety among young individuals, and have significant implications for clinical practice and policy making.

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Melatonin improves fertilization rate in assisted reproduction: Systematic review and meta-analysis
Eduardo Carvalho de Arruda Veiga, Marise Samama, Fabio Ikeda, Giovanna Santos Cavalcanti, Amanda Sartor, Suelen Fernanda Parames, Edmund C. Baracat, Joji Ueno, Jose Maria Soares Junior
Highlights

  • Melatonin had beneficial effects on outcomes in assisted reproductive technologies, but it had no influence on pregnancy.

  • Melatonin had beneficial effects such as the improvement in the fertilization rate.

  • Melatonin has a beneficial effect on the formation of mature oocytes (MII).

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Systematic evaluation and meta-analysis of Flunarizine Hydrochloride combined with traditional Chinese medicine decoction in the treatment of migraine headaches
Dan Fan, Wei Leng, Liqin Zhang
Highlights

  • Flunarizine Hydrochloride combined with TCM notably enhances migraine management.

  • Flunarizine Hydrochloride and TCM improve TCM scores, endothelin, NRS and VAS scores.

  • Flunarizine Hydrochloride combined with TCM reduces headache frequency and duration.

  • Standardized protocols are crucial to understand TCM's role in migraine management better.

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Comments
Parkinson's disease inpatient mortality: Attention to sudden death
Tomás de la Rosa, Fúlvio Alexandre Scorza
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Possible role of artificial intelligence in diagnosis of cases with non-specific signs and symptoms of dengue: A comment
Marcos Roberto Tovani-Palone, Filippo Bistagnino, Jacopo Rosso Antonino, Arunkumar Subramanian
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Correspondence
Increased frequency and intensity of complicated migraine sans migraine after third BNT162b2 dose
Larissa M. Bombardi, Antonio-Carlos Guimaraes de Almeida, Josef Finsterer, Fulvio Alexandre Scorza
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The increasing popularity of Peruvian maca (Lepidium meyenii) and its potential impacts on sleep and quality of life
Vinícius Dokkedal-Silva, Priscila Kalil Morelhão, Sergio Tufik, Monica Levy Andersen
Highlights

  • Peruvian maca is a popular supplement consumed to increase energy and sexual health.

  • Studies report it also has anti-sinflammatory and neuroprotective effects.

  • Stimulant properties of this supplement raise questions about its effects on sleep.

  • Investigation of possible reinforcing characteristics is also recommended.

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Renewed call for action: Highlight negative results to improve science
Bo Pei, Huiye Yang, Shixuan Peng
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NXP-2 positive dermatomyositis with marked dysphagia following an insect bite
Larissa M. Bombardi, Carla Alexandra Scorza, Josef Finsterer, Fulvio Alexandre Scorza
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Transient, self-limiting, antibody-negative myositis with venetoclax
Carla A. Scorza, Josef Finsterer, Fulvio A. Scorza
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos