Reliability of the Brazilian version of the Functional Assessment of Cancer Therapy-Lung (FACT-L) and the FACT-Lung Symptom Index (FLSI)

array:24 ["pii" => "S1807593222015915" "issn" => "18075932" "doi" => "10.1590/S1807-59322010001200005" "estado" => "S300" "fechaPublicacion" => "2010-01-01" "aid" => "1591" "copyright" => "CLINICS" "copyrightAnyo" => "2010" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "fla" "cita" => "Clinics. 2010;65:1247-51" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S1807593222015927" "issn" => "18075932" "doi" => "10.1590/S1807-59322010001200006" "estado" => "S300" "fechaPublicacion" => "2010-01-01" "aid" => "1592" "copyright" => "CLINICS" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "fla" "cita" => "Clinics. 2010;65:1253-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "CLINICAL SCIENCE" "titulo" => "Isokinetic assessment of the hip muscles in patients with osteoarthritis of the knee" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1253" "paginaFinal" => "1259" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1620 "Ancho" => 747 "Tamanyo" => 174495 ] ] "descripcion" => array:1 [ "en" => "Position for performing the flexion–extension movements (A), abduction–adduction movements (B), and medial and lateral rotation movements (C)." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Renata Alqualo Costa, Leda Magalhaes de Oliveira, Sandra Hiroko Watanabe, Anamaria Jones, Jamil Natour" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Renata Alqualo" "apellidos" => "Costa" ] 1 => array:2 [ "nombre" => "Leda Magalhaes" "apellidos" => "de Oliveira" ] 2 => array:2 [ "nombre" => "Sandra Hiroko" "apellidos" => "Watanabe" ] 3 => array:2 [ "nombre" => "Anamaria" "apellidos" => "Jones" ] 4 => array:2 [ "nombre" => "Jamil" "apellidos" => "Natour" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222015927?idApp=UINPBA00004N" "url" => "/18075932/0000006500000012/v1_202212011539/S1807593222015927/v1_202212011539/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1807593222015903" "issn" => "18075932" "doi" => "10.1590/S1807-59322010001200004" "estado" => "S300" "fechaPublicacion" => "2010-01-01" "aid" => "1590" "copyright" => "CLINICS" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "fla" "cita" => "Clinics. 2010;65:1239-45" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "CLINICAL SCIENCE" "titulo" => "Influence of preoperative serum N-terminal pro-brain type natriuretic peptide on the postoperative outcome and survival rates of coronary artery bypass patients" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1239" "paginaFinal" => "1245" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 390 "Ancho" => 478 "Tamanyo" => 15820 ] ] "descripcion" => array:1 [ "en" => "Survival rate of coronary artery bypass patients with preoperative serum N-terminal pro-brain type natriuretic peptide (NT-proBNP) levels > 502 ng/l compared with NT-proBNP levels < 502 ng/l." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Thomas Schachner, Dominik Wiedemann, Hannes Fetz, Guenther Laufer, Alfred Kocher, Nikolaos Bonaros" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Thomas" "apellidos" => "Schachner" ] 1 => array:2 [ "nombre" => "Dominik" "apellidos" => "Wiedemann" ] 2 => array:2 [ "nombre" => "Hannes" "apellidos" => "Fetz" ] 3 => array:2 [ "nombre" => "Guenther" "apellidos" => "Laufer" ] 4 => array:2 [ "nombre" => "Alfred" "apellidos" => "Kocher" ] 5 => array:2 [ "nombre" => "Nikolaos" "apellidos" => "Bonaros" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222015903?idApp=UINPBA00004N" "url" => "/18075932/0000006500000012/v1_202212011539/S1807593222015903/v1_202212011539/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "CLINICAL SCIENCE" "titulo" => "Reliability of the Brazilian version of the Functional Assessment of Cancer Therapy-Lung (FACT-L) and the FACT-Lung Symptom Index (FLSI)" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1247" "paginaFinal" => "1251" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Franceschini Juliana, José R Jardim, Ana Luisa Godoy Fernandes, Sérgio Jamnik, Ilka Lopes Santoro" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Franceschini" "apellidos" => "Juliana" ] 1 => array:2 [ "nombre" => "José R" "apellidos" => "Jardim" ] 2 => array:2 [ "nombre" => "Ana Luisa Godoy" "apellidos" => "Fernandes" ] 3 => array:2 [ "nombre" => "Sérgio" "apellidos" => "Jamnik" ] 4 => array:4 [ "nombre" => "Ilka Lopes" "apellidos" => "Santoro" "email" => array:1 [ 0 => "ilka@pneumo.epm.br" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Respiratory Diseases Division – Federal University of São Paulo, Botucatu, São Paulo, São Paulo, Brazil" "identificador" => "aff1-cln_65p1247" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Tel.: 55 11 5576-4238" ] ] ] ] "textoCompleto" => "INTRODUCTIONLung cancer has become a disease of great global impact and remains the leading cause of death from cancer in the world.<a class="elsevierStyleCrossRef" href="#bib1">1</a> As smoking and environmental pollution cannot be controlled in the short term, the incidence of lung cancer continues to increase, especially in females.<a class="elsevierStyleCrossRefs" href="#bib2">2,3</a> In Brazil, the estimate for 2010 is approximately 18 new cases per 100 000 men and 10 per 100 000 women, corresponding to 17 800 and 9 930 new cases of lung cancer among men and women respectively.<a class="elsevierStyleCrossRef" href="#bib4">4</a>Advances in lung cancer therapy have been improving survival rates, although the prognosis remains poor. The 5-year survival rate is around 15% in developed countries<a class="elsevierStyleCrossRef" href="#bib1">1</a> and 10% in Brazil.<a class="elsevierStyleCrossRef" href="#bib4">4</a> Therefore, the impact of both disease and treatment on the health and psychosocial functioning of these patients should be considered.<a class="elsevierStyleCrossRef" href="#bib5">5</a> In this context, quality of life assessment and the analysis of the main symptoms that lead to functional capacity limitation have become issues of utmost importance in the evaluation of lung cancer patients. However, in Brazil, there are few studies that evaluate this aspect of the disease, mainly because of the lack of specific tools adapted to and reproducible for the Brazilian Portuguese language.Several instruments are currently used to evaluate the quality of life in patients with lung cancer. The Functional Assessment of Cancer Therapy-Lung (FACT-L) was generated by the Functional Assessment of Chronic Illness Therapy (FACIT) group. It is a specific, multidimensional questionnaire widely used in clinical studies.<a class="elsevierStyleCrossRefs" href="#bib6">6-9</a> Moreover, the FACT-Lung Symptom Index (FLSI), which is a brief measure involving five common symptoms in lung cancer patients, can be applied in combination with the FACT-L or alone.Although the FACT-L is currently used in Brazil, mainly in international multicenter trails, there is no study assessing the reliability of this questionnaire in the Brazilian Portuguese language. Therefore, the purpose of this study was to evaluate the reproducibility of the FACT-L and the FLSI for Brazilian lung cancer patients.METHODSA convenience sample comprising 30 patients with lung cancer was recruited from the outpatient lung cancer clinic of the São Paulo Hospital - Federal University of São Paulo. This study was approved by the Institutional Review Board of our center, and a Term of Informed Consent was signed by all patients.The following inclusion criteria were used: histologically proven lung cancer; 18 years of age or older; a minimum score of 21 on the Mini Mental State Examination (MMSE);<a class="elsevierStyleCrossRefs" href="#bib10">10,11</a> out of chemotherapy/radiotherapy treatment; and clinical stability during the study and at least 10 days before the beginning of the evaluations. Clinical stability was defined as the absence of change in cough, sputum, and dyspnea, assessed by a structured form filled out during outpatient follow-up, and no hospitalizations or modifications in the therapeutic regimen. An exclusion criterion was the refusal to answer any questionnaire.The sample size was based on previous reliability studies of other quality of life questionnaires related to respiratory diseases in Brazil.<a class="elsevierStyleCrossRefs" href="#bib12">12–15</a>Clinical evaluation and physical examination were performed by a team of physicians, based on a structured form. All patients met the stability criteria. The drug regimen used by the patients remained unchanged during the 15-day interval between questionnaire applications.In the first visit, the following independent variables were collected: gender (male and female proportion), age (in years), history of tobacco use (yes or no) and consumption (pack–years), histologic subtypes (adenocarcinoma, squamous cell, small cell lung cancer and others),<a class="elsevierStyleCrossRef" href="#bib16">16</a> staging according to the 1997 TNM classification for non-small cell lung cancer (NSCLC) patients (stratified from IA to IIIA and from IIIB to IV),<a class="elsevierStyleCrossRef" href="#bib17">17</a> Karnofsky Performance Status (KPS),<a class="elsevierStyleCrossRef" href="#bib18">18</a> spirometry (forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC) percentage of predicted and FEV1/FVC percentage),<a class="elsevierStyleCrossRef" href="#bib19">19</a> MMSE, and FACT-L and FLSI scores.<a class="elsevierStyleCrossRef" href="#bib9">9</a>The Portuguese version of the FACT-L and FLSI was released for use by the FACIT group (the developer of the questionnaire). The translation into Brazilian Portuguese, back translation and review by an expert committee to access the semantic, conceptual, idiomatic, cultural and metabolic equivalences were previously done by that group.<a class="elsevierStyleCrossRefs" href="#bib20">20,21</a>The FACT-L, version 4, is a combination of the 27-item FACT-General (FACT-G) and the 9-item Lung Cancer Subscale (LCS).A total FACT-G score is calculated by summing the physical well-being (PWB), social/family well-being (SWB), emotional well-being (EWB), and functional well-being (FWB) subscale scores, with a score ranging from 0 to 108. A total FACT-L score is obtained by summing the FACT-G score with the LCS (two of the nine items are not scored). The FACT-L score ranges from 0 to 136.<a class="elsevierStyleCrossRef" href="#bib6">6</a>The FACT-L Trial Outcome Index (FACT-L TOI) is, a priori, an index that sums the PWB, FWB, and LCS into a 21-item scale. Its score ranges from 0 to 84.<a class="elsevierStyleCrossRef" href="#bib6">6</a>The FLSI is a symptom index with six questions regarding the five most frequent symptoms reported by lung cancer patients, especially in the advanced stages: dyspnea, fatigue, pain, weight loss, and coughing. Its score ranges from 0 to 24.Higher scores generated by the FACT-L and FLSI correspond to better quality of life.The score on each aspect of the FACT-L and FLSI is obtained according to the option chosen by the patient. The available options were: “not at all”, “a little bit”, “somewhat”, “quite a bit”, or “very much”. The higher the score obtained by each patient in question, the greater the final score of the subscale and the better the quality of life. However, these scores have a non-linear behavior.Patients answered the questionnaire after being read each question, all by the same interviewer. The process took place in a calm environment with no interruptions allowed. The questionnaires were reviewed at the end of the interview to avoid any missed questions. The response time was timed in the two visits.All doubts expressed by patients during the questionnaire were documented. Patients were also asked not only about what they felt in terms of question content, but also about the length of the questionnaire.The test–retest design was adopted for the reliability study. The questionnaire was administered by the same researcher twice with a 15-day interval.The scores obtained on different scales and subscales of FACT-G were compared with reference values established by the FACIT group.<a class="elsevierStyleCrossRef" href="#bib22">22</a> For this comparison, we used the minimal clinically significant difference, determined by the same group.<a class="elsevierStyleCrossRef" href="#bib6">6</a>Statistical analysisVariables were expressed as mean and standard deviation. The intraclass correlation coefficient (ICC) and Kappa reliability coefficient were calculated to assess the reliability of the questionnaire and questions respectively. To compare the two groups, we used the chi-square test for categorical variables, t test for parametric continuous variables, and Mann–Whitney test for nonparametric continuous variables. For the correlations between spirometry and questionnaire scores, the Spearman's correlation coefficient was used. Statistical analysis was performed with SPSS® software version 13.0. All tests were two-tailed, and the level of significance was 5%.RESULTSThe main characteristics of the 30 patients who completed the study are shown in <a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>. Some 63.3% of the patients were over 60 years of age.<elsevierMultimedia ident="tbl1"></elsevierMultimedia>There was no statistically significant difference between genders regarding age, KPS, spirometry, staging, and histological type.Among patients who never smoked, only one had a history of passive smoking. There was a prevalence of smoking habits in males (p = 0.04), with a higher tobacco smoke load for men than for women, consuming a mean of 53.2 pack–years (SD = 31.6) and 29.6 pack–years (SD = 25.5) respectively (p = 0.02).Eight patients (26.7%) were diagnosed with chronic obstructive pulmonary disease (COPD), according to the GOLD guideline.<a class="elsevierStyleCrossRef" href="#bib23">23</a>The mean values for each scale of the FACT-L and FLSI are illustrated in <a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>. The intraclass correlation coefficient values for the different scales of the FACT-L and FLSI showed excellent correlations (<a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>).<elsevierMultimedia ident="tbl2"></elsevierMultimedia>The kappa coefficient was used to test question reliability, which was less than 0.4 on questions GP1, GP5 (PWB), GS3, GS4, GS5 (SWB), GF1, GF2, GF3, GF5, GF6 (FWB), and LCL4 (LCS). The remaining questions had a moderate agreement. As for the FLSI, the kappa coefficient was moderate on question B1. In the other questions, the kappa coefficient was less than 0.4.There was no correlation between spirometry and any of the questionnaire scales.The mean score of the FACT-G scales was similar to the reference values for all scales that have these values established.<a class="elsevierStyleCrossRef" href="#bib22">22</a><a class="elsevierStyleCrossRef" href="#tbl3">Table 3</a> shows the mean values for the scales of FACT-G and FACT-L described in several studies of reliability and cultural adaptation into other languages.<elsevierMultimedia ident="tbl3"></elsevierMultimedia>The time spent by patients in answering the questionnaire was measured at both visits (<a class="elsevierStyleCrossRef" href="#tbl4">Table 4</a>). The response time on the second application was significantly lower (p = 0.001).<elsevierMultimedia ident="tbl4"></elsevierMultimedia>DISCUSSIONThe focus of this study was to analyze the reliability of the FACT-L and the FLSI, a specific instrument for assessing the quality of life of lung cancer patients in the Brazilian population. It was observed that the Brazilian version shows excellent reliability for this population.The FACT-L is an instrument that has been widely used in phase I, II, and III clinical trials. It has been translated and adapted into several languages and cultures.<a class="elsevierStyleCrossRefs" href="#bib2">2,3,7,22,24</a>–<a class="elsevierStyleCrossRef" href="#bib27">27</a> A feature of this instrument is the nonlinearity of the scores of its scales, a factor that complicates the interpretation of isolated study data. To facilitate the explanation of the results, the authors of the general questionnaire (FACT-G) have developed normative values from two reference groups, one from normal adults and another from adults with cancer in general.<a class="elsevierStyleCrossRef" href="#bib22">22</a> However, these normative values are only for the general questionnaire (FACT-G) and its scales. When comparing the results obtained in our study with the reference values, we observe that the score was similar in all scales and for the total value. A possible explanation for the fact that our patients have quality of life similar to patients with other cancer types is that, in the study for the establishment of benchmarks, besides including patients with various types of cancer, such as breast cancer, colon and rectum cancer, and cancer of the head and neck, they also included patients with lung cancer. Furthermore, 76.7% of the sample comprised patients treated and in remission from the underlying disease and, therefore, with better quality of life. When our FACT-L results are compared with those from other studies using the same questionnaire, we find that there is great variability between countries and different cultures,<a class="elsevierStyleCrossRefs" href="#bib2">2,3,7,22,24</a>–<a class="elsevierStyleCrossRef" href="#bib27">27</a> which may be due to differing perceptions of the questions according to each culture and also differences in patient characteristics, such as staging, age, socioeconomic status, among others.The FLSI is an index designed to identify the presence of the major symptoms related to lung cancer, including dyspnea, pain, fatigue, cough, and weight loss.<a class="elsevierStyleCrossRef" href="#bib28">28</a> These symptoms can negatively influence quality of life. In this study, in addition to the medical evaluation, FLSI was also used to assess the patient's clinical stability.The reliability for all scores of the FACT-L showed ICC values greater than 0.75, ranging from 0.78 (SWB) to 0.96 (FACT-L TOI). These values show excellent reliability and are similar to those found in other studies. In the validation study of the Korean version of the FACT-L,<a class="elsevierStyleCrossRef" href="#bib25">25</a> the ICC ranged from 0.52 to 0.84. The Chinese version<a class="elsevierStyleCrossRef" href="#bib3">3</a> varied from 0.76 to 0.82. In the reliability study of the original version, the ICC ranged from 0.56 (SWB) to 0.89 (FACT-L TOI).<a class="elsevierStyleCrossRef" href="#bib7">7</a> The FLSI also showed high reliability, which confirms the stability of the sample. Most of the FACT-L questions showed adequate reliability, analyzed by the kappa coefficient.In this study, the reliability analyses were conducted with a convenience sample similar to other studies evaluating the reliability and cultural adaptation of other questionnaires to the Portuguese language.<a class="elsevierStyleCrossRefs" href="#bib12">12–15</a>In our sample, males predominated, in agreement with the worldwide prevalence of lung cancer.<a class="elsevierStyleCrossRef" href="#bib1">1</a> The mean age was 61.3 years, which is consistent with most studies that include patients with lung cancer.<a class="elsevierStyleCrossRefs" href="#bib1">1,5</a> Regarding histological type, adenocarcinoma was the most prevalent, consistent with several epidemiological studies in developed countries.<a class="elsevierStyleCrossRef" href="#bib1">1</a> Unfortunately, regarding staging, there was a predominance of stage III and IV, stages with less chance of survival after treatment.<a class="elsevierStyleCrossRef" href="#bib29">29</a> The mean FEV1 (% predicted) and FEV1/FVC ratio in our study were similar to the results reported by Young et al., who observed a FEV1 (% predicted) mean of 73% and FEV1/FVC mean of 64% in smokers with lung cancer.<a class="elsevierStyleCrossRef" href="#bib30">30</a> In our study, there was no correlation between the questionnaire and the analyzed lung function parameters, consistent with other studies that found no significant correlation when investigating the effects of altered pulmonary function on the quality of life of cancer patients.<a class="elsevierStyleCrossRefs" href="#bib31">31,32</a>The process of translating the FACT-L questionnaire and FLSI into the Portuguese language (Brazil) was performed by the FACIT group. Only a few doubts were reported by the patients, which warrants its use in the current form.Few patients had difficulty in interpreting the word “muitíssimo”; however, many of the patients interviewed understood the meaning of the term not because it is a familiar word, but because they realized that it was a scale with a progressive score in which the numerical value assigned to the word “muitíssimo” yielded the highest score. The suggested changes were sent to the FACIT group.Alterations to this tool were proposed only for question Q1 “Independentemente do seu nível a(c)tual de a(c)tividade sexual, favor de responder à pergunta a seguir. Se preferir não responder, assinale o quadrículo □ e passe para a próxima seção”. Despite not raising doubts, the words “atual” and “atividade” do not require the letter “(c)”, and there is no need to use the preposition “de” after the word “favor”, both grammatical constructions used in the Portuguese language in Portugal.We conclude that the Brazilian version of the FACT-L questionnaire and FLSI is reproducible, fast, and of simple application, and that they are capable of measuring the quality of life in lung cancer patients in Brazil." "textoCompletoSecciones" => array:1 [ "secciones" => array:6 [ 0 => array:2 [ "identificador" => "xpalclavsec1582575" "titulo" => "KEYWORDS" ] 1 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 2 => array:3 [ "identificador" => "cesec20" "titulo" => "METHODS" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "cesec30" "titulo" => "Statistical analysis" ] ] ] 3 => array:2 [ "identificador" => "cesec40" "titulo" => "RESULTS" ] 4 => array:2 [ "identificador" => "cesec50" "titulo" => "DISCUSSION" ] 5 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-08-12" "fechaAceptado" => "2010-09-07" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1582575" "palabras" => array:5 [ 0 => "Quality of life" 1 => "Lung cancer" 2 => "Questionnaires" 3 => "Reproducibility of results" 4 => "Validation studies" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "OBJECTIVES:The purpose of this study was to assess the reliability of the Brazilian version of the Functional Assessment of Cancer Therapy-Lung (FACT-L) with the FACT-Lung Symptom Index (FLSI) questionnaire. INTRODUCTION:The assessment of quality of life in patients with lung cancer has become an important evaluative endpoint in current clinical trials. For lung cancer patients, one of the most common quality of life tools available is the FACT-L. Despite the amount of data available regarding this questionnaire, there are no data on its performance in Brazilian lung cancer patients. METHODS:The FACT-L with the FLSI questionnaire was prospectively administered to 30 consecutive, stable, lung cancer outpatients at baseline and at 2 weeks. RESULTS:The intraclass correlation coefficient between test and retest for the FACT-L ranged from 0.79 to 0.96 and for the FLSI was 0.87. There was no correlation between these questionnaire dimensions and clinical or functional parameters. CONCLUSIONS:The Brazilian version of the FACT-L with FLSI questionnaire is reliable and is quick and simple to apply. This instrument can now be used to properly evaluate the quality of life of Brazilian lung cancer patients." "secciones" => array:5 [ 0 => array:2 [ "identificador" => "ceabs10" "titulo" => "OBJECTIVES:" ] 1 => array:2 [ "identificador" => "ceabs20" "titulo" => "INTRODUCTION:" ] 2 => array:2 [ "identificador" => "ceabs30" "titulo" => "METHODS:" ] 3 => array:2 [ "identificador" => "ceabs40" "titulo" => "RESULTS:" ] 4 => array:2 [ "identificador" => "ceabs50" "titulo" => "CONCLUSIONS:" ] ] ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "tbl1" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "SD, standard deviation; FEV1, forced expiratory volume in the first second; FVC, forced vital capacity; SCLC, small cell lung cancer; KPS, Karnofsky Performance Status." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Variables \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (years) mean±SD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">62.0±10.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23 (73.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Smoking history</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Former smokers n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">27 (90) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Never smokers n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (10) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pack–year mean±DP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">52.5±33.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Spirometry mean±DP</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FEV1 % prev \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">75.0±19.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FVC % prev \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">86.7±13.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FEV1 / FVC % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">71.8±12.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Histological types n (%)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Adenocarcinoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 (46.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Squamous cells \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 (30) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SCLC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (6.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Others \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (16.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">KPS mean±SD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">93.2±9.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Staging status n (%)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">I and II \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 (46.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 (43.3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">IV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (10) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Mini Mental mean±SD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">27.9±1.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Subject characteristics of 30 lung cancer patients." ] ] 1 => array:7 [ "identificador" => "tbl2" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "FACT-G, Functional Assessment of Cancer Therapy-General; LCS, Lung Cancer Scale; FACT-L, Functional Assessment of Cancer Therapy-Lung; FACT-L TOI, Functional Assessment of Cancer Therapy-Lung Trial Outcome Index; FLSI, Functional Assessment of Cancer Therapy-Lung Symptom Index." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Scales \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">1st visit \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">2nd visit \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">ICC \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Physical well-being \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.90 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Social/family well-being \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.78 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Emotional well-being \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.92 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Functional well-being \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.89 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FACT-G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">78.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">76.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.93 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LCS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.94 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FACT-L \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">98.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">97.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.95 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FACT-L TOI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">61.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">59.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.96 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">FLSI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">19.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">18.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">0.87 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Mean for the two visits (15-day interval) and intraclass correlation coefficient (ICC) for FACT-L scales and FLSI." ] ] 2 => array:7 [ "identificador" => "tbl3" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "PWB, physical well-being; S/FWB, social/family well-being; EWB, emotional well-being; FWB, functional well-being; FACT-G, Functional Assessment of Cancer Therapy-General; LCS, Lung Cancer Scale; FACT-L, Functional Assessment of Cancer Therapy-Lung; FACT-L TOI, Functional Assessment of Cancer Therapy-Lung Trial Outcome Index." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Source \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">PWB \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">S/FWB \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">EWB \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">FWB \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">FACT-G \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">LCS \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">FACT-L \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">FACT-L TOI \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Current study \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">76.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">95.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">57.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Brucker et al 2005 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">80.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Browning et al 2009 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">81.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Wan et al 2007 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">65.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">82.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Saitoh et al 2007 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yoo et al 2006 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">84.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">59.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cella et al 2003 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">73.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">94.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">33.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dapueto et al 2003 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">63.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Cella et al 1995 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">20.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">23.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">15.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">17.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">84.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">20.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">59.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Mean values for the FACT-L scales in different reliability and validity trials with cancer patients." ] ] 3 => array:7 [ "identificador" => "tbl4" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "FACT-L, Functional Assessment of Cancer Therapy-Lung; FLSI, Functional Assessment of Cancer Therapy-Lung Symptom Index." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Mean \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Median \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">SD \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Range \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1st FACT-L + FLSI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5–20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">2nd FACT-L + FLSI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">9.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">2.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">4–15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Response time of the FACT-L and FLSI and p value of the comparison between the two visits (Student's t test)." ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:32 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Environment and Genetics in Lung cancer Etiology (EAGLE) study: an integrative population-based case-control study of lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ MT Landi \n \t\t\t\t\t\t\t\t """ 1 => """ D Consonni \n \t\t\t\t\t\t\t\t """ 2 => """ M Rotunno \n \t\t\t\t\t\t\t\t """ 3 => """ AW Bergen \n \t\t\t\t\t\t\t\t """ 4 => """ AM Goldstein \n \t\t\t\t\t\t\t\t """ 5 => """ JH Lubin \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1186/1471-2458-8-203" "Revista" => array:5 [ "tituloSerie" => "BMC Public Health" "fecha" => "2008" "volumen" => "8" "paginaInicial" => "203" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18538025" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1186/1471-2458-8-203" "WWW" => array:1 [ "link" => "https://doi.org/10.1186/1471-2458-8-203" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A psychometric analysis of quality of life tools in lung cancer patients who smoke" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ KK Browning \n \t\t\t\t\t\t\t\t """ 1 => """ AK Ferketich \n \t\t\t\t\t\t\t\t """ 2 => """ GA Otterson \n \t\t\t\t\t\t\t\t """ 3 => """ NR Reynolds \n \t\t\t\t\t\t\t\t """ 4 => """ ME Wewers \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Lung Cancer" "fecha" => "2009" "volumen" => "66" "paginaInicial" => "9" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.lungcan.2008.12.018" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psychometric properties of the Chinese version of the FACT-L for measuring quality of life in patients with lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ C Wan \n \t\t\t\t\t\t\t\t """ 1 => """ C Zhang \n \t\t\t\t\t\t\t\t """ 2 => """ L Cai \n \t\t\t\t\t\t\t\t """ 3 => """ X Tu \n \t\t\t\t\t\t\t\t """ 4 => """ C Feng \n \t\t\t\t\t\t\t\t """ 5 => """ J Luo \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Lung Cancer" "fecha" => "2007" "volumen" => "56" "paginaInicial" => "21" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.lungcan.2007.01.004" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Brasil. Ministério da Saúde." "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "Instituto Nacional de Câncer I. Estimativa 2010: Incidência de Câncer no Brasil" "fecha" => "2009" "editorial" => "INCA" "editorialLocalizacion" => "Rio de Janeiro" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "[Assessment of the quality of life of patients with lung cancer using the Medical Outcomes Study 36-item Short-Form Health Survey]" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ J Franceschini \n \t\t\t\t\t\t\t\t """ 1 => """ AA Santos \n \t\t\t\t\t\t\t\t """ 2 => """ I El Mouallem \n \t\t\t\t\t\t\t\t """ 3 => """ S Jamnik \n \t\t\t\t\t\t\t\t """ 4 => """ C Uehara \n \t\t\t\t\t\t\t\t """ 5 => """ AL Fernandes \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J Bras Pneumol" "fecha" => "2008" "volumen" => "34" "paginaInicial" => "93" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1590/S1806-37132008000600009" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quality of life in lung cancer: the validity and cross-cultural applicability of the Functional Assessment of Cancer Therapy-Lung scale" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ Z Butt \n \t\t\t\t\t\t\t\t """ 1 => """ K Webster \n \t\t\t\t\t\t\t\t """ 2 => """ AR Eisenstein \n \t\t\t\t\t\t\t\t """ 3 => """ J Beaumont \n \t\t\t\t\t\t\t\t """ 4 => """ D Eton \n \t\t\t\t\t\t\t\t """ 5 => """ GA Masters \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Hematol Oncol Clin North Am" "fecha" => "2005" "volumen" => "19" "paginaInicial" => "420, viii" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.hoc.2005.02.009" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reliability and validity of the Functional Assessment of Cancer Therapy-Lung (FACT-L) quality of life instrument" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ DF Cella \n \t\t\t\t\t\t\t\t """ 1 => """ AE Bonomi \n \t\t\t\t\t\t\t\t """ 2 => """ SR Lloyd \n \t\t\t\t\t\t\t\t """ 3 => """ DS Tulsky \n \t\t\t\t\t\t\t\t """ 4 => """ E Kaplan \n \t\t\t\t\t\t\t\t """ 5 => """ P Bonomi \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Lung Cancer" "fecha" => "1995" "volumen" => "12" "paginaInicial" => "220" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1016/0169-5002(95)00450-F" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quality of life in patients with lung cancer: a review of literature from 1970 to 1995" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ A Montazeri \n \t\t\t\t\t\t\t\t """ 1 => """ CR Gillis \n \t\t\t\t\t\t\t\t """ 2 => """ J McEwen \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Chest" "fecha" => "1998" "volumen" => "113" "paginaInicial" => "81" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1378/chest.113.2.467" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Functional Assessment of Chronic Illness Therapy (FACIT) measurement system: properties, applications, and interpretation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ K Webster \n \t\t\t\t\t\t\t\t """ 1 => """ D Cella \n \t\t\t\t\t\t\t\t """ 2 => """ K Yost \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1186/1477-7525-1-79" "Revista" => array:5 [ "tituloSerie" => "Health Qual Life Outcomes" "fecha" => "2003" "volumen" => "1" "paginaInicial" => "79" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14678568" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1186/1477-7525-1-79" "WWW" => array:1 [ "link" => "https://doi.org/10.1186/1477-7525-1-79" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "“Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ MF Folstein \n \t\t\t\t\t\t\t\t """ 1 => """ SE Folstein \n \t\t\t\t\t\t\t\t """ 2 => """ PR McHugh \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J Psychiatr Res" "fecha" => "1975" "volumen" => "12" "paginaInicial" => "98" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1016/0022-3956(75)90026-6" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "[Mini mental state examination and the diagnosis of dementia in Brazil]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ OP Almeida \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Arq Neuropsiquiatr" "fecha" => "1998" "volumen" => "56" "paginaInicial" => "12" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Using the Saint George's Respiratory Questionnaire to evaluate quality of life in patients with chronic obstructive pulmonary disease: validating a new version for use in Brazil" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ A Camelier \n \t\t\t\t\t\t\t\t """ 1 => """ FW Rosa \n \t\t\t\t\t\t\t\t """ 2 => """ C Salim \n \t\t\t\t\t\t\t\t """ 3 => """ OA Nascimento \n \t\t\t\t\t\t\t\t """ 4 => """ F Cardoso \n \t\t\t\t\t\t\t\t """ 5 => """ JR Jardim \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J Bras Pneumol" "fecha" => "2006" "volumen" => "32" "paginaInicial" => "22" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1590/S1806-37132006000200006" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Brazilian Portuguese version of the London Chest Activity of Daily Living scale for use in patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ MF Carpes \n \t\t\t\t\t\t\t\t """ 1 => """ AF Mayer \n \t\t\t\t\t\t\t\t """ 2 => """ KM Simon \n \t\t\t\t\t\t\t\t """ 3 => """ JR Jardim \n \t\t\t\t\t\t\t\t """ 4 => """ R Garrod \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J Bras Pneumol" "fecha" => "2008" "volumen" => "34" "paginaInicial" => "51" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1590/S1806-37132008000300004" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validação do Questionário do Hospital Saint George na Doença Respiratória (SGRQ) em pacientes portadores de doença pulmonar obstrutiva crônica no Brasil" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ T Sousa \n \t\t\t\t\t\t\t\t """ 1 => """ J Jardim \n \t\t\t\t\t\t\t\t """ 2 => """ P Jones \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J Pneumol" "fecha" => "2000" "volumen" => "26" "paginaInicial" => "28" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation of the Modified Pulmonary Functional Status and Dyspnea Questionnaire and the Medical Research Council scale for use in Brazilian patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ D Kovelis \n \t\t\t\t\t\t\t\t """ 1 => """ NO Segretti \n \t\t\t\t\t\t\t\t """ 2 => """ VS Probst \n \t\t\t\t\t\t\t\t """ 3 => """ SC Lareau \n \t\t\t\t\t\t\t\t """ 4 => """ AF Brunetto \n \t\t\t\t\t\t\t\t """ 5 => """ F Pitta \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J Bras Pneumol" "fecha" => "2008" "volumen" => "34" "paginaInicial" => "18" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Câncer de pulmão: diagnóstico e estadiamento" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ C Uehara \n \t\t\t\t\t\t\t\t """ 1 => """ I Santoro \n \t\t\t\t\t\t\t\t """ 2 => """ R Ferreira \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "editores" => "LNery, AFernandes, JPerfeito" "titulo" => "Pneumologia" "paginaInicial" => "495" "paginaFinal" => "509" "serieFecha" => "2006" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Revisions in the International System for Staging Lung Cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ CF Mountain \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Chest" "fecha" => "1997" "volumen" => "111" "paginaInicial" => "17" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1378/chest.111.6.1710" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Preliminary studies on the natural history of lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ DA Karnofsky \n \t\t\t\t\t\t\t\t """ 1 => """ RB Golbey \n \t\t\t\t\t\t\t\t """ 2 => """ JL Pool \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1148/69.1.88" "Revista" => array:5 [ "tituloSerie" => "Radiology" "fecha" => "1957" "volumen" => "69" "paginaInicial" => "88" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13453719" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Espirometria" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ C Pereira \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pneumol" "fecha" => "2002" "volumen" => "28" "numero" => "Suppl. 3" "paginaInicial" => "S1" "paginaFinal" => "S82" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development of a single Portuguese language version of the Functional Assessment of Cancer Therapy - General (FACT-G) Scale" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ BJ Arnold \n \t\t\t\t\t\t\t\t """ 1 => """ E Eremenco \n \t\t\t\t\t\t\t\t """ 2 => """ C-H Chang \n \t\t\t\t\t\t\t\t """ 3 => """ L Odom \n \t\t\t\t\t\t\t\t """ 4 => """ JM Ribaudo \n \t\t\t\t\t\t\t\t """ 5 => """ D Cella \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Qual Life Res" "fecha" => "2000" "volumen" => "9" "paginaInicial" => "316" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "How much is “very much”? Developing a rating scale for Portuguese speaking countries" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ BJ Arnold \n \t\t\t\t\t\t\t\t """ 1 => """ S Eremenco \n \t\t\t\t\t\t\t\t """ 2 => """ CH Chang \n \t\t\t\t\t\t\t\t """ 3 => """ D Cella \n \t\t\t\t\t\t\t\t """ 4 => """ JLP Riberiro \n \t\t\t\t\t\t\t\t """ 5 => """ MP Doro \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Qual Life Res" "fecha" => "2001" "volumen" => "10" "paginaInicial" => "264" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "General population and cancer patient norms for the Functional Assessment of Cancer Therapy-General (FACT-G)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ PS Brucker \n \t\t\t\t\t\t\t\t """ 1 => """ K Yost \n \t\t\t\t\t\t\t\t """ 2 => """ J Cashy \n \t\t\t\t\t\t\t\t """ 3 => """ K Webster \n \t\t\t\t\t\t\t\t """ 4 => """ D Cella \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Eval Health Prof" "fecha" => "2005" "volumen" => "28" "paginaInicial" => "211" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1177/0163278705275341" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ R Rodriguez-Roisin \n \t\t\t\t\t\t\t\t """ 1 => """ A Anzueto \n \t\t\t\t\t\t\t\t """ 2 => """ J Bourbeau \n \t\t\t\t\t\t\t\t """ 3 => """ P Calverley \n \t\t\t\t\t\t\t\t """ 4 => """ T DeGuia \n \t\t\t\t\t\t\t\t """ 5 => """ Y Fukuchi \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "titulo" => "GOLD – Global Initiative for Chronic Obstructive Pulmonary Disease – Pocket Guide to COPD Diagnoses, Management and Prevention. A Guide for Healthcare Professionals" "fecha" => "2009" "editorial" => "Medical Communications Resources, Inc." ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cross-cultural validation of the Japanese version of the lung cancer subscale on the Functional Assessment of Cancer Therapy-Lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ E Saitoh \n \t\t\t\t\t\t\t\t """ 1 => """ Y Yokomizo \n \t\t\t\t\t\t\t\t """ 2 => """ C-H Chang \n \t\t\t\t\t\t\t\t """ 3 => """ S Eremenco \n \t\t\t\t\t\t\t\t """ 4 => """ H Kaneko \n \t\t\t\t\t\t\t\t """ 5 => """ K Kobayashi \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J Nippon Med Sch" "fecha" => "2007" "volumen" => "74" "paginaInicial" => "8" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1272/jnms.74.402" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Korean translation and validation of the Functional Assessment of Cancer Therapy-Lung (FACT-L) version 4" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ H Yoo \n \t\t\t\t\t\t\t\t """ 1 => """ C Suh \n \t\t\t\t\t\t\t\t """ 2 => """ S Kim \n \t\t\t\t\t\t\t\t """ 3 => """ S Eremenco \n \t\t\t\t\t\t\t\t """ 4 => """ H Kim \n \t\t\t\t\t\t\t\t """ 5 => """ S Kim \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Qual Life Res" "fecha" => "2006" "volumen" => "15" "paginaInicial" => "6" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1007/s11136-005-8752-x" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Measuring the side effects of taxane therapy in oncology: the Functional Assessment of Cancer Therapy-Taxane (FACT-taxane)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ D Cella \n \t\t\t\t\t\t\t\t """ 1 => """ A Peterman \n \t\t\t\t\t\t\t\t """ 2 => """ S Hudgens \n \t\t\t\t\t\t\t\t """ 3 => """ K Webster \n \t\t\t\t\t\t\t\t """ 4 => """ MA Socinski \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1002/cncr.11442" "Revista" => array:5 [ "tituloSerie" => "Cancer" "fecha" => "2003" "volumen" => "98" "paginaInicial" => "31" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12833452" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1002/cncr.11442" "WWW" => array:1 [ "link" => "https://doi.org/10.1002/cncr.11578" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of the Functional Assessment of Cancer Therapy-General (FACT-G) Spanish version 4 in South America: classic psychometric and item response theory analyses" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ JJ Dapueto \n \t\t\t\t\t\t\t\t """ 1 => """ C Francolino \n \t\t\t\t\t\t\t\t """ 2 => """ L Servente \n \t\t\t\t\t\t\t\t """ 3 => """ CH Chang \n \t\t\t\t\t\t\t\t """ 4 => """ I Gotta \n \t\t\t\t\t\t\t\t """ 5 => """ R Levin \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1186/1477-7525-1-32" "Revista" => array:5 [ "tituloSerie" => "Health Qual Life Outcomes" "fecha" => "2003" "volumen" => "1" "paginaInicial" => "32" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12969512" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1186/1477-7525-1-32" "WWW" => array:1 [ "link" => "https://doi.org/10.1186/1477-7525-1-32" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation of the Functional Assessment of Cancer Therapy-Lung Symptom Index-12 (FLSI-12)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ DT Eton \n \t\t\t\t\t\t\t\t """ 1 => """ D Cella \n \t\t\t\t\t\t\t\t """ 2 => """ SE Yount \n \t\t\t\t\t\t\t\t """ 3 => """ KM Davis \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Lung Cancer" "fecha" => "2007" "volumen" => "57" "paginaInicial" => "47" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.lungcan.2007.03.021" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung cancer: current diagnosis and treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ S Hammerschmidt \n \t\t\t\t\t\t\t\t """ 1 => """ H Wirtz \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Dtsch Arztebl Int" "fecha" => "2009" "volumen" => "106" "paginaInicial" => "18" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung cancer susceptibility model based on age, family history and genetic variants" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ RP Young \n \t\t\t\t\t\t\t\t """ 1 => """ RJ Hopkins \n \t\t\t\t\t\t\t\t """ 2 => """ BA Hay \n \t\t\t\t\t\t\t\t """ 3 => """ MJ Epton \n \t\t\t\t\t\t\t\t """ 4 => """ GD Mills \n \t\t\t\t\t\t\t\t """ 5 => """ PN Black \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0005302" "Revista" => array:5 [ "tituloSerie" => "PLoS One" "fecha" => "2009" "volumen" => "4" "paginaInicial" => "e5302" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19390575" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1371/journal.pone.0005302" "WWW" => array:1 [ "link" => "https://doi.org/10.1371/journal.pone.0005302" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluating quality of life and pulmonary function of long-term survivors of non-small cell lung cancer treated with radical or postoperative radiotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ A Ozturk \n \t\t\t\t\t\t\t\t """ 1 => """ S Sarihan \n \t\t\t\t\t\t\t\t """ 2 => """ I Ercan \n \t\t\t\t\t\t\t\t """ 3 => """ M Karadag \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Am J Clin Oncol" "fecha" => "2009" "volumen" => "32" "paginaInicial" => "72" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1097/COC.0b013e31817e6ec2" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of respiratory symptoms and pulmonary function on quality of life of long-term survivors of non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ L Sarna \n \t\t\t\t\t\t\t\t """ 1 => """ L Evangelista \n \t\t\t\t\t\t\t\t """ 2 => """ D Tashkin \n \t\t\t\t\t\t\t\t """ 3 => """ G Padilla \n \t\t\t\t\t\t\t\t """ 4 => """ C Holmes \n \t\t\t\t\t\t\t\t """ 5 => """ ML Brecht \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Chest" "fecha" => "2004" "volumen" => "125" "paginaInicial" => "45" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1378/chest.125.2.439" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/18075932/0000006500000012/v1_202212011539/S1807593222015915/v1_202212011539/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/18075932/0000006500000012/v1_202212011539/S1807593222015915/v1_202212011539/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222015915?idApp=UINPBA00004N"]

Statistics

CLINICAL SCIENCE

Franceschini Juliana, José R Jardim, Ana Luisa Godoy Fernandes, Sérgio Jamnik, Ilka Lopes Santoro

Corresponding author

ilka@pneumo.epm.br

Tel.: 55 11 5576-4238

Respiratory Diseases Division – Federal University of São Paulo, Botucatu, São Paulo, São Paulo, Brazil

Read

582

Times
was read the article

252

Total PDF

330

Total HTML

Share statistics

 array:24 [
  "pii" => "S1807593222015915"
  "issn" => "18075932"
  "doi" => "10.1590/S1807-59322010001200005"
  "estado" => "S300"
  "fechaPublicacion" => "2010-01-01"
  "aid" => "1591"
  "copyright" => "CLINICS"
  "copyrightAnyo" => "2010"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
  "subdocumento" => "fla"
  "cita" => "Clinics. 2010;65:1247-51"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1807593222015927"
    "issn" => "18075932"
    "doi" => "10.1590/S1807-59322010001200006"
    "estado" => "S300"
    "fechaPublicacion" => "2010-01-01"
    "aid" => "1592"
    "copyright" => "CLINICS"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
    "subdocumento" => "fla"
    "cita" => "Clinics. 2010;65:1253-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">CLINICAL SCIENCE</span>"
      "titulo" => "Isokinetic assessment of the hip muscles in patients with osteoarthritis of the knee"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "1253"
          "paginaFinal" => "1259"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig1"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1620
              "Ancho" => 747
              "Tamanyo" => 174495
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Position for performing the flexion&#8211;extension movements &#40;A&#41;&#44; abduction&#8211;adduction movements &#40;B&#41;&#44; and medial and lateral rotation movements &#40;C&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Renata Alqualo Costa, Leda Magalhaes de Oliveira, Sandra Hiroko Watanabe, Anamaria Jones, Jamil Natour"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Renata Alqualo"
              "apellidos" => "Costa"
            ]
            1 => array:2 [
              "nombre" => "Leda Magalhaes"
              "apellidos" => "de Oliveira"
            ]
            2 => array:2 [
              "nombre" => "Sandra Hiroko"
              "apellidos" => "Watanabe"
            ]
            3 => array:2 [
              "nombre" => "Anamaria"
              "apellidos" => "Jones"
            ]
            4 => array:2 [
              "nombre" => "Jamil"
              "apellidos" => "Natour"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222015927?idApp=UINPBA00004N"
    "url" => "/18075932/0000006500000012/v1_202212011539/S1807593222015927/v1_202212011539/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1807593222015903"
    "issn" => "18075932"
    "doi" => "10.1590/S1807-59322010001200004"
    "estado" => "S300"
    "fechaPublicacion" => "2010-01-01"
    "aid" => "1590"
    "copyright" => "CLINICS"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
    "subdocumento" => "fla"
    "cita" => "Clinics. 2010;65:1239-45"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">CLINICAL SCIENCE</span>"
      "titulo" => "Influence of preoperative serum N-terminal pro-brain type natriuretic peptide on the postoperative outcome and survival rates of coronary artery bypass patients"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "1239"
          "paginaFinal" => "1245"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig2"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 390
              "Ancho" => 478
              "Tamanyo" => 15820
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Survival rate of coronary artery bypass patients with preoperative serum N-terminal pro-brain type natriuretic peptide &#40;NT-proBNP&#41; levels &#62; 502 ng&#47;l compared with NT-proBNP levels &#60; 502 ng&#47;l&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Thomas Schachner, Dominik Wiedemann, Hannes Fetz, Guenther Laufer, Alfred Kocher, Nikolaos Bonaros"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Thomas"
              "apellidos" => "Schachner"
            ]
            1 => array:2 [
              "nombre" => "Dominik"
              "apellidos" => "Wiedemann"
            ]
            2 => array:2 [
              "nombre" => "Hannes"
              "apellidos" => "Fetz"
            ]
            3 => array:2 [
              "nombre" => "Guenther"
              "apellidos" => "Laufer"
            ]
            4 => array:2 [
              "nombre" => "Alfred"
              "apellidos" => "Kocher"
            ]
            5 => array:2 [
              "nombre" => "Nikolaos"
              "apellidos" => "Bonaros"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222015903?idApp=UINPBA00004N"
    "url" => "/18075932/0000006500000012/v1_202212011539/S1807593222015903/v1_202212011539/en/main.assets"
  ]
  "en" => array:17 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">CLINICAL SCIENCE</span>"
    "titulo" => "Reliability of the Brazilian version of the Functional Assessment of Cancer Therapy-Lung &#40;FACT-L&#41; and the FACT-Lung Symptom Index &#40;FLSI&#41;"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "1247"
        "paginaFinal" => "1251"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Franceschini Juliana, Jos&#233; R Jardim, Ana Luisa Godoy Fernandes, S&#233;rgio Jamnik, Ilka Lopes Santoro"
        "autores" => array:5 [
          0 => array:2 [
            "nombre" => "Franceschini"
            "apellidos" => "Juliana"
          ]
          1 => array:2 [
            "nombre" => "Jos&#233; R"
            "apellidos" => "Jardim"
          ]
          2 => array:2 [
            "nombre" => "Ana Luisa Godoy"
            "apellidos" => "Fernandes"
          ]
          3 => array:2 [
            "nombre" => "S&#233;rgio"
            "apellidos" => "Jamnik"
          ]
          4 => array:4 [
            "nombre" => "Ilka Lopes"
            "apellidos" => "Santoro"
            "email" => array:1 [
              0 => "ilka@pneumo.epm.br"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor1"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Respiratory Diseases Division &#8211; Federal University of S&#227;o Paulo&#44; Botucatu&#44; S&#227;o Paulo&#44; S&#227;o Paulo&#44; Brazil"
            "identificador" => "aff1-cln_65p1247"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#42;"
            "correspondencia" => "Tel&#46;&#58; 55 11 5576-4238"
          ]
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">Lung cancer has become a disease of great global impact and remains the leading cause of death from cancer in the world&#46;<a class="elsevierStyleCrossRef" href="#bib1">1</a> As smoking and environmental pollution cannot be controlled in the short term&#44; the incidence of lung cancer continues to increase&#44; especially in females&#46;<a class="elsevierStyleCrossRefs" href="#bib2">2&#44;3</a> In Brazil&#44; the estimate for 2010 is approximately 18 new cases per 100&#8201;000 men and 10 per 100&#8201;000 women&#44; corresponding to 17&#8201;800 and 9&#8201;930 new cases of lung cancer among men and women respectively&#46;<a class="elsevierStyleCrossRef" href="#bib4">4</a></p><p id="para20" class="elsevierStylePara elsevierViewall">Advances in lung cancer therapy have been improving survival rates&#44; although the prognosis remains poor&#46; The 5-year survival rate is around 15&#37; in developed countries<a class="elsevierStyleCrossRef" href="#bib1">1</a> and 10&#37; in Brazil&#46;<a class="elsevierStyleCrossRef" href="#bib4">4</a> Therefore&#44; the impact of both disease and treatment on the health and psychosocial functioning of these patients should be considered&#46;<a class="elsevierStyleCrossRef" href="#bib5">5</a> In this context&#44; quality of life assessment and the analysis of the main symptoms that lead to functional capacity limitation have become issues of utmost importance in the evaluation of lung cancer patients&#46; However&#44; in Brazil&#44; there are few studies that evaluate this aspect of the disease&#44; mainly because of the lack of specific tools adapted to and reproducible for the Brazilian Portuguese language&#46;</p><p id="para30" class="elsevierStylePara elsevierViewall">Several instruments are currently used to evaluate the quality of life in patients with lung cancer&#46; The Functional Assessment of Cancer Therapy-Lung &#40;FACT-L&#41; was generated by the Functional Assessment of Chronic Illness Therapy &#40;FACIT&#41; group&#46; It is a specific&#44; multidimensional questionnaire widely used in clinical studies&#46;<a class="elsevierStyleCrossRefs" href="#bib6">6-9</a> Moreover&#44; the FACT-Lung Symptom Index &#40;FLSI&#41;&#44; which is a brief measure involving five common symptoms in lung cancer patients&#44; can be applied in combination with the FACT-L or alone&#46;</p><p id="para40" class="elsevierStylePara elsevierViewall">Although the FACT-L is currently used in Brazil&#44; mainly in international multicenter trails&#44; there is no study assessing the reliability of this questionnaire in the Brazilian Portuguese language&#46; Therefore&#44; the purpose of this study was to evaluate the reproducibility of the FACT-L and the FLSI for Brazilian lung cancer patients&#46;</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">METHODS</span><p id="para50" class="elsevierStylePara elsevierViewall">A convenience sample comprising 30 patients with lung cancer was recruited from the outpatient lung cancer clinic of the S&#227;o Paulo Hospital - Federal University of S&#227;o Paulo&#46; This study was approved by the Institutional Review Board of our center&#44; and a Term of Informed Consent was signed by all patients&#46;</p><p id="para60" class="elsevierStylePara elsevierViewall">The following inclusion criteria were used&#58; histologically proven lung cancer&#59; 18 years of age or older&#59; a minimum score of 21 on the Mini Mental State Examination &#40;MMSE&#41;&#59;<a class="elsevierStyleCrossRefs" href="#bib10">10&#44;11</a> out of chemotherapy&#47;radiotherapy treatment&#59; and clinical stability during the study and at least 10 days before the beginning of the evaluations&#46; Clinical stability was defined as the absence of change in cough&#44; sputum&#44; and dyspnea&#44; assessed by a structured form filled out during outpatient follow-up&#44; and no hospitalizations or modifications in the therapeutic regimen&#46; An exclusion criterion was the refusal to answer any questionnaire&#46;</p><p id="para70" class="elsevierStylePara elsevierViewall">The sample size was based on previous reliability studies of other quality of life questionnaires related to respiratory diseases in Brazil&#46;<a class="elsevierStyleCrossRefs" href="#bib12"><span class="elsevierStyleSup">12&#8211;15</span></a></p><p id="para80" class="elsevierStylePara elsevierViewall">Clinical evaluation and physical examination were performed by a team of physicians&#44; based on a structured form&#46; All patients met the stability criteria&#46; The drug regimen used by the patients remained unchanged during the 15-day interval between questionnaire applications&#46;</p><p id="para90" class="elsevierStylePara elsevierViewall">In the first visit&#44; the following independent variables were collected&#58; gender &#40;male and female proportion&#41;&#44; age &#40;in years&#41;&#44; history of tobacco use &#40;yes or no&#41; and consumption &#40;pack&#8211;years&#41;&#44; histologic subtypes &#40;adenocarcinoma&#44; squamous cell&#44; small cell lung cancer and others&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib16">16</a> staging according to the 1997 TNM classification for non-small cell lung cancer &#40;NSCLC&#41; patients &#40;stratified from IA to IIIA and from IIIB to IV&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib17">17</a> Karnofsky Performance Status &#40;KPS&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib18">18</a> spirometry &#40;forced expiratory volume in the first second &#40;FEV<span class="elsevierStyleInf">1</span>&#41; and forced vital capacity &#40;FVC&#41; percentage of predicted and FEV<span class="elsevierStyleInf">1</span>&#47;FVC percentage&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib19">19</a> MMSE&#44; and FACT-L and FLSI scores&#46;<a class="elsevierStyleCrossRef" href="#bib9">9</a></p><p id="para100" class="elsevierStylePara elsevierViewall">The Portuguese version of the FACT-L and FLSI was released for use by the FACIT group &#40;the developer of the questionnaire&#41;&#46; The translation into Brazilian Portuguese&#44; back translation and review by an expert committee to access the semantic&#44; conceptual&#44; idiomatic&#44; cultural and metabolic equivalences were previously done by that group&#46;<a class="elsevierStyleCrossRefs" href="#bib20">20&#44;21</a></p><p id="para110" class="elsevierStylePara elsevierViewall">The FACT-L&#44; version 4&#44; is a combination of the 27-item FACT-General &#40;FACT-G&#41; and the 9-item Lung Cancer Subscale &#40;LCS&#41;&#46;</p><p id="para120" class="elsevierStylePara elsevierViewall">A total FACT-G score is calculated by summing the physical well-being &#40;PWB&#41;&#44; social&#47;family well-being &#40;SWB&#41;&#44; emotional well-being &#40;EWB&#41;&#44; and functional well-being &#40;FWB&#41; subscale scores&#44; with a score ranging from 0 to 108&#46; A total FACT-L score is obtained by summing the FACT-G score with the LCS &#40;two of the nine items are not scored&#41;&#46; The FACT-L score ranges from 0 to 136&#46;<a class="elsevierStyleCrossRef" href="#bib6">6</a></p><p id="para130" class="elsevierStylePara elsevierViewall">The FACT-L Trial Outcome Index &#40;FACT-L TOI&#41; is&#44; <span class="elsevierStyleItalic">a priori</span>&#44; an index that sums the PWB&#44; FWB&#44; and LCS into a 21-item scale&#46; Its score ranges from 0 to 84&#46;<a class="elsevierStyleCrossRef" href="#bib6">6</a></p><p id="para140" class="elsevierStylePara elsevierViewall">The FLSI is a symptom index with six questions regarding the five most frequent symptoms reported by lung cancer patients&#44; especially in the advanced stages&#58; dyspnea&#44; fatigue&#44; pain&#44; weight loss&#44; and coughing&#46; Its score ranges from 0 to 24&#46;</p><p id="para150" class="elsevierStylePara elsevierViewall">Higher scores generated by the FACT-L and FLSI correspond to better quality of life&#46;</p><p id="para160" class="elsevierStylePara elsevierViewall">The score on each aspect of the FACT-L and FLSI is obtained according to the option chosen by the patient&#46; The available options were&#58; &#8220;not at all&#8221;&#44; &#8220;a little bit&#8221;&#44; &#8220;somewhat&#8221;&#44; &#8220;quite a bit&#8221;&#44; or &#8220;very much&#8221;&#46; The higher the score obtained by each patient in question&#44; the greater the final score of the subscale and the better the quality of life&#46; However&#44; these scores have a non-linear behavior&#46;</p><p id="para170" class="elsevierStylePara elsevierViewall">Patients answered the questionnaire after being read each question&#44; all by the same interviewer&#46; The process took place in a calm environment with no interruptions allowed&#46; The questionnaires were reviewed at the end of the interview to avoid any missed questions&#46; The response time was timed in the two visits&#46;</p><p id="para180" class="elsevierStylePara elsevierViewall">All doubts expressed by patients during the questionnaire were documented&#46; Patients were also asked not only about what they felt in terms of question content&#44; but also about the length of the questionnaire&#46;</p><p id="para190" class="elsevierStylePara elsevierViewall">The test&#8211;retest design was adopted for the reliability study&#46; The questionnaire was administered by the same researcher twice with a 15-day interval&#46;</p><p id="para200" class="elsevierStylePara elsevierViewall">The scores obtained on different scales and subscales of FACT-G were compared with reference values established by the FACIT group&#46;<a class="elsevierStyleCrossRef" href="#bib22">22</a> For this comparison&#44; we used the minimal clinically significant difference&#44; determined by the same group&#46;<a class="elsevierStyleCrossRef" href="#bib6">6</a></p><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">Statistical analysis</span><p id="para210" class="elsevierStylePara elsevierViewall">Variables were expressed as mean and standard deviation&#46; The intraclass correlation coefficient &#40;ICC&#41; and Kappa reliability coefficient were calculated to assess the reliability of the questionnaire and questions respectively&#46; To compare the two groups&#44; we used the chi-square test for categorical variables&#44; t test for parametric continuous variables&#44; and Mann&#8211;Whitney test for nonparametric continuous variables&#46; For the correlations between spirometry and questionnaire scores&#44; the Spearman&#39;s correlation coefficient was used&#46; Statistical analysis was performed with SPSS&#174; software version 13&#46;0&#46; All tests were two-tailed&#44; and the level of significance was 5&#37;&#46;</p></span></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle100">RESULTS</span><p id="para220" class="elsevierStylePara elsevierViewall">The main characteristics of the 30 patients who completed the study are shown in <a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>&#46; Some 63&#46;3&#37; of the patients were over 60 years of age&#46;</p><elsevierMultimedia ident="tbl1"></elsevierMultimedia><p id="para230" class="elsevierStylePara elsevierViewall">There was no statistically significant difference between genders regarding age&#44; KPS&#44; spirometry&#44; staging&#44; and histological type&#46;</p><p id="para240" class="elsevierStylePara elsevierViewall">Among patients who never smoked&#44; only one had a history of passive smoking&#46; There was a prevalence of smoking habits in males &#40;<span class="elsevierStyleItalic">p</span>&#8200;&#61;&#8200;0&#46;04&#41;&#44; with a higher tobacco smoke load for men than for women&#44; consuming a mean of 53&#46;2 pack&#8211;years &#40;SD&#8200;&#61;&#8200;31&#46;6&#41; and 29&#46;6 pack&#8211;years &#40;SD&#8200;&#61;&#8200;25&#46;5&#41; respectively &#40;<span class="elsevierStyleItalic">p</span>&#8200;&#61;&#8200;0&#46;02&#41;&#46;</p><p id="para250" class="elsevierStylePara elsevierViewall">Eight patients &#40;26&#46;7&#37;&#41; were diagnosed with chronic obstructive pulmonary disease &#40;COPD&#41;&#44; according to the GOLD guideline&#46;<a class="elsevierStyleCrossRef" href="#bib23">23</a></p><p id="para260" class="elsevierStylePara elsevierViewall">The mean values for each scale of the FACT-L and FLSI are illustrated in <a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>&#46; The intraclass correlation coefficient values for the different scales of the FACT-L and FLSI showed excellent correlations &#40;<a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl2"></elsevierMultimedia><p id="para270" class="elsevierStylePara elsevierViewall">The kappa coefficient was used to test question reliability&#44; which was less than 0&#46;4 on questions GP1&#44; GP5 &#40;PWB&#41;&#44; GS3&#44; GS4&#44; GS5 &#40;SWB&#41;&#44; GF1&#44; GF2&#44; GF3&#44; GF5&#44; GF6 &#40;FWB&#41;&#44; and LCL4 &#40;LCS&#41;&#46; The remaining questions had a moderate agreement&#46; As for the FLSI&#44; the kappa coefficient was moderate on question B1&#46; In the other questions&#44; the kappa coefficient was less than 0&#46;4&#46;</p><p id="para280" class="elsevierStylePara elsevierViewall">There was no correlation between spirometry and any of the questionnaire scales&#46;</p><p id="para290" class="elsevierStylePara elsevierViewall">The mean score of the FACT-G scales was similar to the reference values for all scales that have these values established&#46;<a class="elsevierStyleCrossRef" href="#bib22">22</a><a class="elsevierStyleCrossRef" href="#tbl3">Table 3</a> shows the mean values for the scales of FACT-G and FACT-L described in several studies of reliability and cultural adaptation into other languages&#46;</p><elsevierMultimedia ident="tbl3"></elsevierMultimedia><p id="para300" class="elsevierStylePara elsevierViewall">The time spent by patients in answering the questionnaire was measured at both visits &#40;<a class="elsevierStyleCrossRef" href="#tbl4">Table 4</a>&#41;&#46; The response time on the second application was significantly lower &#40;<span class="elsevierStyleItalic">p</span>&#8200;&#61;&#8200;0&#46;001&#41;&#46;</p><elsevierMultimedia ident="tbl4"></elsevierMultimedia></span><span id="cesec50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle110">DISCUSSION</span><p id="para310" class="elsevierStylePara elsevierViewall">The focus of this study was to analyze the reliability of the FACT-L and the FLSI&#44; a specific instrument for assessing the quality of life of lung cancer patients in the Brazilian population&#46; It was observed that the Brazilian version shows excellent reliability for this population&#46;</p><p id="para320" class="elsevierStylePara elsevierViewall">The FACT-L is an instrument that has been widely used in phase I&#44; II&#44; and III clinical trials&#46; It has been translated and adapted into several languages and cultures&#46;<a class="elsevierStyleCrossRefs" href="#bib2">2&#44;3&#44;7&#44;22&#44;24</a>&#8211;<a class="elsevierStyleCrossRef" href="#bib27">27</a> A feature of this instrument is the nonlinearity of the scores of its scales&#44; a factor that complicates the interpretation of isolated study data&#46; To facilitate the explanation of the results&#44; the authors of the general questionnaire &#40;FACT-G&#41; have developed normative values from two reference groups&#44; one from normal adults and another from adults with cancer in general&#46;<a class="elsevierStyleCrossRef" href="#bib22">22</a> However&#44; these normative values are only for the general questionnaire &#40;FACT-G&#41; and its scales&#46; When comparing the results obtained in our study with the reference values&#44; we observe that the score was similar in all scales and for the total value&#46; A possible explanation for the fact that our patients have quality of life similar to patients with other cancer types is that&#44; in the study for the establishment of benchmarks&#44; besides including patients with various types of cancer&#44; such as breast cancer&#44; colon and rectum cancer&#44; and cancer of the head and neck&#44; they also included patients with lung cancer&#46; Furthermore&#44; 76&#46;7&#37; of the sample comprised patients treated and in remission from the underlying disease and&#44; therefore&#44; with better quality of life&#46; When our FACT-L results are compared with those from other studies using the same questionnaire&#44; we find that there is great variability between countries and different cultures&#44;<a class="elsevierStyleCrossRefs" href="#bib2">2&#44;3&#44;7&#44;22&#44;24</a>&#8211;<a class="elsevierStyleCrossRef" href="#bib27">27</a> which may be due to differing perceptions of the questions according to each culture and also differences in patient characteristics&#44; such as staging&#44; age&#44; socioeconomic status&#44; among others&#46;</p><p id="para330" class="elsevierStylePara elsevierViewall">The FLSI is an index designed to identify the presence of the major symptoms related to lung cancer&#44; including dyspnea&#44; pain&#44; fatigue&#44; cough&#44; and weight loss&#46;<a class="elsevierStyleCrossRef" href="#bib28">28</a> These symptoms can negatively influence quality of life&#46; In this study&#44; in addition to the medical evaluation&#44; FLSI was also used to assess the patient&#39;s clinical stability&#46;</p><p id="para340" class="elsevierStylePara elsevierViewall">The reliability for all scores of the FACT-L showed ICC values greater than 0&#46;75&#44; ranging from 0&#46;78 &#40;SWB&#41; to 0&#46;96 &#40;FACT-L TOI&#41;&#46; These values show excellent reliability and are similar to those found in other studies&#46; In the validation study of the Korean version of the FACT-L&#44;<a class="elsevierStyleCrossRef" href="#bib25">25</a> the ICC ranged from 0&#46;52 to 0&#46;84&#46; The Chinese version<a class="elsevierStyleCrossRef" href="#bib3">3</a> varied from 0&#46;76 to 0&#46;82&#46; In the reliability study of the original version&#44; the ICC ranged from 0&#46;56 &#40;SWB&#41; to 0&#46;89 &#40;FACT-L TOI&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib7">7</a> The FLSI also showed high reliability&#44; which confirms the stability of the sample&#46; Most of the FACT-L questions showed adequate reliability&#44; analyzed by the kappa coefficient&#46;</p><p id="para350" class="elsevierStylePara elsevierViewall">In this study&#44; the reliability analyses were conducted with a convenience sample similar to other studies evaluating the reliability and cultural adaptation of other questionnaires to the Portuguese language&#46;<a class="elsevierStyleCrossRefs" href="#bib12"><span class="elsevierStyleSup">12&#8211;15</span></a></p><p id="para360" class="elsevierStylePara elsevierViewall">In our sample&#44; males predominated&#44; in agreement with the worldwide prevalence of lung cancer&#46;<a class="elsevierStyleCrossRef" href="#bib1">1</a> The mean age was 61&#46;3 years&#44; which is consistent with most studies that include patients with lung cancer&#46;<a class="elsevierStyleCrossRefs" href="#bib1">1&#44;5</a> Regarding histological type&#44; adenocarcinoma was the most prevalent&#44; consistent with several epidemiological studies in developed countries&#46;<a class="elsevierStyleCrossRef" href="#bib1">1</a> Unfortunately&#44; regarding staging&#44; there was a predominance of stage III and IV&#44; stages with less chance of survival after treatment&#46;<a class="elsevierStyleCrossRef" href="#bib29">29</a> The mean FEV<span class="elsevierStyleInf">1</span> &#40;&#37; predicted&#41; and FEV<span class="elsevierStyleInf">1</span>&#47;FVC ratio in our study were similar to the results reported by Young et al&#46;&#44; who observed a FEV<span class="elsevierStyleInf">1</span> &#40;&#37; predicted&#41; mean of 73&#37; and FEV<span class="elsevierStyleInf">1</span>&#47;FVC mean of 64&#37; in smokers with lung cancer&#46;<a class="elsevierStyleCrossRef" href="#bib30">30</a> In our study&#44; there was no correlation between the questionnaire and the analyzed lung function parameters&#44; consistent with other studies that found no significant correlation when investigating the effects of altered pulmonary function on the quality of life of cancer patients&#46;<a class="elsevierStyleCrossRefs" href="#bib31">31&#44;32</a></p><p id="para370" class="elsevierStylePara elsevierViewall">The process of translating the FACT-L questionnaire and FLSI into the Portuguese language &#40;Brazil&#41; was performed by the FACIT group&#46; Only a few doubts were reported by the patients&#44; which warrants its use in the current form&#46;</p><p id="para380" class="elsevierStylePara elsevierViewall">Few patients had difficulty in interpreting the word &#8220;muit&#237;ssimo&#8221;&#59; however&#44; many of the patients interviewed understood the meaning of the term not because it is a familiar word&#44; but because they realized that it was a scale with a progressive score in which the numerical value assigned to the word &#8220;muit&#237;ssimo&#8221; yielded the highest score&#46; The suggested changes were sent to the FACIT group&#46;</p><p id="para390" class="elsevierStylePara elsevierViewall">Alterations to this tool were proposed only for question Q1 &#8220;Independentemente do seu n&#237;vel a&#40;c&#41;tual de a&#40;c&#41;tividade sexual&#44; favor de responder &#224; pergunta a seguir&#46; Se preferir n&#227;o responder&#44; assinale o quadr&#237;culo &#9633; e passe para a pr&#243;xima se&#231;&#227;o&#8221;&#46; Despite not raising doubts&#44; the words &#8220;atual&#8221; and &#8220;atividade&#8221; do not require the letter &#8220;&#40;c&#41;&#8221;&#44; and there is no need to use the preposition &#8220;de&#8221; after the word &#8220;favor&#8221;&#44; both grammatical constructions used in the Portuguese language in Portugal&#46;</p><p id="para400" class="elsevierStylePara elsevierViewall">We conclude that the Brazilian version of the FACT-L questionnaire and FLSI is reproducible&#44; fast&#44; and of simple application&#44; and that they are capable of measuring the quality of life in lung cancer patients in Brazil&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:6 [
        0 => array:2 [
          "identificador" => "xpalclavsec1582575"
          "titulo" => "KEYWORDS"
        ]
        1 => array:2 [
          "identificador" => "cesec10"
          "titulo" => "INTRODUCTION"
        ]
        2 => array:3 [
          "identificador" => "cesec20"
          "titulo" => "METHODS"
          "secciones" => array:1 [
            0 => array:2 [
              "identificador" => "cesec30"
              "titulo" => "Statistical analysis"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "cesec40"
          "titulo" => "RESULTS"
        ]
        4 => array:2 [
          "identificador" => "cesec50"
          "titulo" => "DISCUSSION"
        ]
        5 => array:1 [
          "titulo" => "REFERENCES"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2010-08-12"
    "fechaAceptado" => "2010-09-07"
    "PalabrasClave" => array:1 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "KEYWORDS"
          "identificador" => "xpalclavsec1582575"
          "palabras" => array:5 [
            0 => "Quality of life"
            1 => "Lung cancer"
            2 => "Questionnaires"
            3 => "Reproducibility of results"
            4 => "Validation studies"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:1 [
      "en" => array:2 [
        "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">OBJECTIVES&#58;</span><p id="spara90" class="elsevierStyleSimplePara elsevierViewall">The purpose of this study was to assess the reliability of the Brazilian version of the Functional Assessment of Cancer Therapy-Lung &#40;FACT-L&#41; with the FACT-Lung Symptom Index &#40;FLSI&#41; questionnaire&#46;</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">INTRODUCTION&#58;</span><p id="spara100" class="elsevierStyleSimplePara elsevierViewall">The assessment of quality of life in patients with lung cancer has become an important evaluative endpoint in current clinical trials&#46; For lung cancer patients&#44; one of the most common quality of life tools available is the FACT-L&#46; Despite the amount of data available regarding this questionnaire&#44; there are no data on its performance in Brazilian lung cancer patients&#46;</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">METHODS&#58;</span><p id="spara110" class="elsevierStyleSimplePara elsevierViewall">The FACT-L with the FLSI questionnaire was prospectively administered to 30 consecutive&#44; stable&#44; lung cancer outpatients at baseline and at 2 weeks&#46;</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">RESULTS&#58;</span><p id="spara120" class="elsevierStyleSimplePara elsevierViewall">The intraclass correlation coefficient between test and retest for the FACT-L ranged from 0&#46;79 to 0&#46;96 and for the FLSI was 0&#46;87&#46; There was no correlation between these questionnaire dimensions and clinical or functional parameters&#46;</p></span> <span id="ceabs50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle50">CONCLUSIONS&#58;</span><p id="spara130" class="elsevierStyleSimplePara elsevierViewall">The Brazilian version of the FACT-L with FLSI questionnaire is reliable and is quick and simple to apply&#46; This instrument can now be used to properly evaluate the quality of life of Brazilian lung cancer patients&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "ceabs10"
            "titulo" => "OBJECTIVES&#58;"
          ]
          1 => array:2 [
            "identificador" => "ceabs20"
            "titulo" => "INTRODUCTION&#58;"
          ]
          2 => array:2 [
            "identificador" => "ceabs30"
            "titulo" => "METHODS&#58;"
          ]
          3 => array:2 [
            "identificador" => "ceabs40"
            "titulo" => "RESULTS&#58;"
          ]
          4 => array:2 [
            "identificador" => "ceabs50"
            "titulo" => "CONCLUSIONS&#58;"
          ]
        ]
      ]
    ]
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "tbl1"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">SD&#44; standard deviation&#59; FEV<span class="elsevierStyleInf">1</span>&#44; forced expiratory volume in the first second&#59; FVC&#44; forced vital capacity&#59; SCLC&#44; small cell lung cancer&#59; KPS&#44; Karnofsky Performance Status&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Variables&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age &#40;years&#41; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62&#46;0&#177;10&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;73&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Smoking history</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Former smokers n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;90&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Never smokers n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pack&#8211;year mean&#177;DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#46;5&#177;33&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Spirometry mean&#177;DP</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>FEV<span class="elsevierStyleInf">1</span> &#37; prev&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&#46;0&#177;19&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>FVC &#37; prev&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86&#46;7&#177;13&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>FEV<span class="elsevierStyleInf">1</span> &#47; FVC &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">71&#46;8&#177;12&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Histological types n &#40;&#37;&#41;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Adenocarcinoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;46&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Squamous cells&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SCLC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;6&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Others&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;16&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">KPS mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93&#46;2&#177;9&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Staging status n &#40;&#37;&#41;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>I and II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;46&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;43&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Mini Mental mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">27&#46;9&#177;1&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Subject characteristics of 30 lung cancer patients&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl2"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">FACT-G&#44; Functional Assessment of Cancer Therapy-General&#59; LCS&#44; Lung Cancer Scale&#59; FACT-L&#44; Functional Assessment of Cancer Therapy-Lung&#59; FACT-L TOI&#44; Functional Assessment of Cancer Therapy-Lung Trial Outcome Index&#59; FLSI&#44; Functional Assessment of Cancer Therapy-Lung Symptom Index&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Scales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">1st visit&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">2nd visit&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">ICC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Physical well-being&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Social&#47;family well-being&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Emotional well-being&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Functional well-being&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FACT-G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LCS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FACT-L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">98&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">97&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FACT-L TOI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">FLSI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">19&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">18&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">0&#46;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Mean for the two visits &#40;15-day interval&#41; and intraclass correlation coefficient &#40;ICC&#41; for FACT-L scales and FLSI&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl3"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spara60" class="elsevierStyleSimplePara elsevierViewall">PWB&#44; physical well-being&#59; S&#47;FWB&#44; social&#47;family well-being&#59; EWB&#44; emotional well-being&#59; FWB&#44; functional well-being&#59; FACT-G&#44; Functional Assessment of Cancer Therapy-General&#59; LCS&#44; Lung Cancer Scale&#59; FACT-L&#44; Functional Assessment of Cancer Therapy-Lung&#59; FACT-L TOI&#44; Functional Assessment of Cancer Therapy-Lung Trial Outcome Index&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Source&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">PWB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">S&#47;FWB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">EWB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">FWB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">FACT-G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">LCS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">FACT-L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">FACT-L TOI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Current study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">95&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Brucker et al 2005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Browning et al 2009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">81&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Wan et al 2007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">65&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">82&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Saitoh et al 2007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yoo et al 2006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cella et al 2003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">94&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dapueto et al 2003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Cella et al 1995&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">20&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">23&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">15&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">17&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">84&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">20&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">59&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara50" class="elsevierStyleSimplePara elsevierViewall">Mean values for the FACT-L scales in different reliability and validity trials with cancer patients&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl4"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spara80" class="elsevierStyleSimplePara elsevierViewall">FACT-L&#44; Functional Assessment of Cancer Therapy-Lung&#59; FLSI&#44; Functional Assessment of Cancer Therapy-Lung Symptom Index&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Mean&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Median&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1st FACT-L &#43; FLSI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#8211;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">2nd FACT-L &#43; FLSI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">9&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">2&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">4&#8211;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara70" class="elsevierStyleSimplePara elsevierViewall">Response time of the FACT-L and FLSI and <span class="elsevierStyleItalic">p</span> value of the comparison between the two visits &#40;Student&#39;s t test&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "cebibsec10"
          "bibliografiaReferencia" => array:32 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Environment and Genetics in Lung cancer Etiology &#40;EAGLE&#41; study&#58; an integrative population-based case-control study of lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              MT Landi \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              D Consonni \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              M Rotunno \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              AW Bergen \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              AM Goldstein \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              JH Lubin \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2458-8-203"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Public Health"
                        "fecha" => "2008"
                        "volumen" => "8"
                        "paginaInicial" => "203"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18538025"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1186/1471-2458-8-203"
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1186&#47;1471-2458-8-203"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A psychometric analysis of quality of life tools in lung cancer patients who smoke"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              KK Browning \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              AK Ferketich \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              GA Otterson \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              NR Reynolds \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              ME Wewers \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Lung Cancer"
                        "fecha" => "2009"
                        "volumen" => "66"
                        "paginaInicial" => "9"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;lungcan&#46;2008&#46;12&#46;018"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psychometric properties of the Chinese version of the FACT-L for measuring quality of life in patients with lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              C Wan \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              C Zhang \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              L Cai \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              X Tu \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              C Feng \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              J Luo \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Lung Cancer"
                        "fecha" => "2007"
                        "volumen" => "56"
                        "paginaInicial" => "21"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;lungcan&#46;2007&#46;01&#46;004"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Brasil&#46; Minist&#233;rio da Sa&#250;de&#46;"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "titulo" => "Instituto Nacional de C&#226;ncer I&#46; Estimativa 2010&#58; Incid&#234;ncia de C&#226;ncer no Brasil"
                        "fecha" => "2009"
                        "editorial" => "INCA"
                        "editorialLocalizacion" => "Rio de Janeiro"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#91;Assessment of the quality of life of patients with lung cancer using the Medical Outcomes Study 36-item Short-Form Health Survey&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              J Franceschini \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              AA Santos \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              I El Mouallem \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              S Jamnik \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              C Uehara \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              AL Fernandes \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Bras Pneumol"
                        "fecha" => "2008"
                        "volumen" => "34"
                        "paginaInicial" => "93"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1590&#47;S1806-37132008000600009"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Quality of life in lung cancer&#58; the validity and cross-cultural applicability of the Functional Assessment of Cancer Therapy-Lung scale"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              Z Butt \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              K Webster \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              AR Eisenstein \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              J Beaumont \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              D Eton \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              GA Masters \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Hematol Oncol Clin North Am"
                        "fecha" => "2005"
                        "volumen" => "19"
                        "paginaInicial" => "420&#44; viii"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;hoc&#46;2005&#46;02&#46;009"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reliability and validity of the Functional Assessment of Cancer Therapy-Lung &#40;FACT-L&#41; quality of life instrument"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              DF Cella \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              AE Bonomi \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              SR Lloyd \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              DS Tulsky \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              E Kaplan \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              P Bonomi \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Lung Cancer"
                        "fecha" => "1995"
                        "volumen" => "12"
                        "paginaInicial" => "220"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;0169-5002&#40;95&#41;00450-F"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Quality of life in patients with lung cancer&#58; a review of literature from 1970 to 1995"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              A Montazeri \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              CR Gillis \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              J McEwen \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1998"
                        "volumen" => "113"
                        "paginaInicial" => "81"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1378&#47;chest&#46;113&#46;2&#46;467"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Functional Assessment of Chronic Illness Therapy &#40;FACIT&#41; measurement system&#58; properties&#44; applications&#44; and interpretation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              K Webster \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              D Cella \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              K Yost \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1186/1477-7525-1-79"
                      "Revista" => array:5 [
                        "tituloSerie" => "Health Qual Life Outcomes"
                        "fecha" => "2003"
                        "volumen" => "1"
                        "paginaInicial" => "79"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14678568"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1186/1477-7525-1-79"
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1186&#47;1477-7525-1-79"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#8220;Mini-mental state&#8221;&#46; A practical method for grading the cognitive state of patients for the clinician"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              MF Folstein \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              SE Folstein \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              PR McHugh \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Psychiatr Res"
                        "fecha" => "1975"
                        "volumen" => "12"
                        "paginaInicial" => "98"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;0022-3956&#40;75&#41;90026-6"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#91;Mini mental state examination and the diagnosis of dementia in Brazil&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => """
                              OP Almeida \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Arq Neuropsiquiatr"
                        "fecha" => "1998"
                        "volumen" => "56"
                        "paginaInicial" => "12"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Using the Saint George&#39;s Respiratory Questionnaire to evaluate quality of life in patients with chronic obstructive pulmonary disease&#58; validating a new version for use in Brazil"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              A Camelier \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              FW Rosa \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              C Salim \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              OA Nascimento \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              F Cardoso \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              JR Jardim \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Bras Pneumol"
                        "fecha" => "2006"
                        "volumen" => "32"
                        "paginaInicial" => "22"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1590&#47;S1806-37132006000200006"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Brazilian Portuguese version of the London Chest Activity of Daily Living scale for use in patients with chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              MF Carpes \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              AF Mayer \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              KM Simon \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              JR Jardim \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              R Garrod \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Bras Pneumol"
                        "fecha" => "2008"
                        "volumen" => "34"
                        "paginaInicial" => "51"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1590&#47;S1806-37132008000300004"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Valida&#231;&#227;o do Question&#225;rio do Hospital Saint George na Doen&#231;a Respirat&#243;ria &#40;SGRQ&#41; em pacientes portadores de doen&#231;a pulmonar obstrutiva cr&#244;nica no Brasil"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              T Sousa \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              J Jardim \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              P Jones \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Pneumol"
                        "fecha" => "2000"
                        "volumen" => "26"
                        "paginaInicial" => "28"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validation of the Modified Pulmonary Functional Status and Dyspnea Questionnaire and the Medical Research Council scale for use in Brazilian patients with chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              D Kovelis \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              NO Segretti \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              VS Probst \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              SC Lareau \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              AF Brunetto \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              F Pitta \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Bras Pneumol"
                        "fecha" => "2008"
                        "volumen" => "34"
                        "paginaInicial" => "18"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "C&#226;ncer de pulm&#227;o&#58; diagn&#243;stico e estadiamento"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              C Uehara \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              I Santoro \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              R Ferreira \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "LNery, AFernandes, JPerfeito"
                        "titulo" => "Pneumologia"
                        "paginaInicial" => "495"
                        "paginaFinal" => "509"
                        "serieFecha" => "2006"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Revisions in the International System for Staging Lung Cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => """
                              CF Mountain \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1997"
                        "volumen" => "111"
                        "paginaInicial" => "17"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1378&#47;chest&#46;111&#46;6&#46;1710"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Preliminary studies on the natural history of lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              DA Karnofsky \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              RB Golbey \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              JL Pool \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1148/69.1.88"
                      "Revista" => array:5 [
                        "tituloSerie" => "Radiology"
                        "fecha" => "1957"
                        "volumen" => "69"
                        "paginaInicial" => "88"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13453719"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Espirometria"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => """
                              C Pereira \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pneumol"
                        "fecha" => "2002"
                        "volumen" => "28"
                        "numero" => "Suppl&#46; 3"
                        "paginaInicial" => "S1"
                        "paginaFinal" => "S82"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Development of a single Portuguese language version of the Functional Assessment of Cancer Therapy - General &#40;FACT-G&#41; Scale"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              BJ Arnold \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              E Eremenco \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              C-H Chang \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              L Odom \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              JM Ribaudo \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              D Cella \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Qual Life Res"
                        "fecha" => "2000"
                        "volumen" => "9"
                        "paginaInicial" => "316"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "How much is &#8220;very much&#8221;&#63; Developing a rating scale for Portuguese speaking countries"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              BJ Arnold \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              S Eremenco \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              CH Chang \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              D Cella \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              JLP Riberiro \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              MP Doro \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Qual Life Res"
                        "fecha" => "2001"
                        "volumen" => "10"
                        "paginaInicial" => "264"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "General population and cancer patient norms for the Functional Assessment of Cancer Therapy-General &#40;FACT-G&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              PS Brucker \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              K Yost \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              J Cashy \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              K Webster \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              D Cella \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Eval Health Prof"
                        "fecha" => "2005"
                        "volumen" => "28"
                        "paginaInicial" => "211"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1177&#47;0163278705275341"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              R Rodriguez-Roisin \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              A Anzueto \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              J Bourbeau \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              P Calverley \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              T DeGuia \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              Y Fukuchi \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "titulo" => "GOLD &#8211; Global Initiative for Chronic Obstructive Pulmonary Disease &#8211; Pocket Guide to COPD Diagnoses&#44; Management and Prevention&#46; A Guide for Healthcare Professionals"
                        "fecha" => "2009"
                        "editorial" => "Medical Communications Resources&#44; Inc&#46;"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cross-cultural validation of the Japanese version of the lung cancer subscale on the Functional Assessment of Cancer Therapy-Lung"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              E Saitoh \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              Y Yokomizo \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              C-H Chang \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              S Eremenco \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              H Kaneko \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              K Kobayashi \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Nippon Med Sch"
                        "fecha" => "2007"
                        "volumen" => "74"
                        "paginaInicial" => "8"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1272&#47;jnms&#46;74&#46;402"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Korean translation and validation of the Functional Assessment of Cancer Therapy-Lung &#40;FACT-L&#41; version 4"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              H Yoo \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              C Suh \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              S Kim \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              S Eremenco \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              H Kim \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              S Kim \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Qual Life Res"
                        "fecha" => "2006"
                        "volumen" => "15"
                        "paginaInicial" => "6"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1007&#47;s11136-005-8752-x"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Measuring the side effects of taxane therapy in oncology&#58; the Functional Assessment of Cancer Therapy-Taxane &#40;FACT-taxane&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              D Cella \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              A Peterman \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              S Hudgens \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              K Webster \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              MA Socinski \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1002/cncr.11442"
                      "Revista" => array:5 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "2003"
                        "volumen" => "98"
                        "paginaInicial" => "31"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12833452"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1002/cncr.11442"
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1002&#47;cncr&#46;11578"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of the Functional Assessment of Cancer Therapy-General &#40;FACT-G&#41; Spanish version 4 in South America&#58; classic psychometric and item response theory analyses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              JJ Dapueto \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              C Francolino \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              L Servente \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              CH Chang \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              I Gotta \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              R Levin \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1186/1477-7525-1-32"
                      "Revista" => array:5 [
                        "tituloSerie" => "Health Qual Life Outcomes"
                        "fecha" => "2003"
                        "volumen" => "1"
                        "paginaInicial" => "32"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12969512"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1186/1477-7525-1-32"
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1186&#47;1477-7525-1-32"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validation of the Functional Assessment of Cancer Therapy-Lung Symptom Index-12 &#40;FLSI-12&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              DT Eton \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              D Cella \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              SE Yount \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              KM Davis \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Lung Cancer"
                        "fecha" => "2007"
                        "volumen" => "57"
                        "paginaInicial" => "47"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;lungcan&#46;2007&#46;03&#46;021"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung cancer&#58; current diagnosis and treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              S Hammerschmidt \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              H Wirtz \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Dtsch Arztebl Int"
                        "fecha" => "2009"
                        "volumen" => "106"
                        "paginaInicial" => "18"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung cancer susceptibility model based on age&#44; family history and genetic variants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              RP Young \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              RJ Hopkins \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              BA Hay \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              MJ Epton \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              GD Mills \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              PN Black \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0005302"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS One"
                        "fecha" => "2009"
                        "volumen" => "4"
                        "paginaInicial" => "e5302"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19390575"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1371/journal.pone.0005302"
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1371&#47;journal&#46;pone&#46;0005302"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluating quality of life and pulmonary function of long-term survivors of non-small cell lung cancer treated with radical or postoperative radiotherapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              A Ozturk \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              S Sarihan \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              I Ercan \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              M Karadag \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Am J Clin Oncol"
                        "fecha" => "2009"
                        "volumen" => "32"
                        "paginaInicial" => "72"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1097&#47;COC&#46;0b013e31817e6ec2"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of respiratory symptoms and pulmonary function on quality of life of long-term survivors of non-small cell lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              L Sarna \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              L Evangelista \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              D Tashkin \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              G Padilla \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              C Holmes \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              ML Brecht \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2004"
                        "volumen" => "125"
                        "paginaInicial" => "45"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1378&#47;chest&#46;125&#46;2&#46;439"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/18075932/0000006500000012/v1_202212011539/S1807593222015915/v1_202212011539/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/18075932/0000006500000012/v1_202212011539/S1807593222015915/v1_202212011539/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222015915?idApp=UINPBA00004N"
]

Article information

ISSN: 18075932
Original language: English

DOI:10.1590/S1807-59322010001200005

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	4	3	7
2024 October	18	18	36
2024 September	32	14	46
2024 August	29	13	42
2024 July	17	20	37
2024 June	19	6	25
2024 May	17	11	28
2024 April	10	10	20
2024 March	14	10	24
2024 February	7	11	18
2024 January	11	10	21
2023 December	4	17	21
2023 November	12	17	29
2023 October	15	20	35
2023 September	17	21	38
2023 August	15	8	23
2023 July	10	13	23
2023 June	13	11	24
2023 May	6	3	9
2023 April	10	1	11
2023 March	8	2	10
2023 February	8	1	9
2023 January	7	9	16
2022 December	27	3	30

Show all

Indexed in:

Follow us:

Statistics

Indexed in:

Follow us:

Statistics

Subscribe to our newsletter