The impact of metabolic syndrome on metabolic, pro-inflammatory and prothrombotic markers according to the presence of high blood pressure criterion

array:24 ["pii" => "S1807593222020361" "issn" => "18075932" "doi" => "10.6061/clinics/2013(12)04" "estado" => "S300" "fechaPublicacion" => "2013-01-01" "aid" => "2036" "copyright" => "CLINICS" "copyrightAnyo" => "2013" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "fla" "cita" => "Clinics. 2013;68:1495-501" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S1807593222020373" "issn" => "18075932" "doi" => "10.6061/clinics/2013(12)05" "estado" => "S300" "fechaPublicacion" => "2013-01-01" "aid" => "2037" "copyright" => "CLINICS" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "fla" "cita" => "Clinics. 2013;68:1502-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "CLINICAL SCIENCE" "titulo" => "The involvement of multiple thrombogenic and atherogenic markers in premature coronary artery disease" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1502" "paginaFinal" => "1508" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1046 "Ancho" => 793 "Tamanyo" => 76689 ] ] "descripcion" => array:1 [ "en" => "Receiver operating characteristic (ROC) curves. Model1 included the following variables: gender, hypertension, smoking, diabetes, family history of CAD, dyslipidemia, and body mass index. Model1 vs. Model1+Lp(a) (p = 0.047); Model1 vs. Model1+Lp(a)+LTA (p = 0.024)." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Antonio P. Mansur, Julio Y. Takada, Célia M.C. Strunz, Solange D. Avakian, Luiz Antonio M. César, José A.F. Ramires" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Antonio P." "apellidos" => "Mansur" ] 1 => array:2 [ "nombre" => "Julio Y." "apellidos" => "Takada" ] 2 => array:2 [ "nombre" => "Célia M.C." "apellidos" => "Strunz" ] 3 => array:2 [ "nombre" => "Solange D." "apellidos" => "Avakian" ] 4 => array:2 [ "nombre" => "Luiz Antonio M." "apellidos" => "César" ] 5 => array:2 [ "nombre" => "José A.F." "apellidos" => "Ramires" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222020373?idApp=UINPBA00004N" "url" => "/18075932/0000006800000012/v1_202212011241/S1807593222020373/v1_202212011241/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S180759322202035X" "issn" => "18075932" "doi" => "10.6061/clinics/2013(12)03" "estado" => "S300" "fechaPublicacion" => "2013-01-01" "aid" => "2035" "copyright" => "CLINICS" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "fla" "cita" => "Clinics. 2013;68:1488-94" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "CLINICAL SCIENCE" "titulo" => "pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1488" "paginaFinal" => "1494" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 411 "Ancho" => 770 "Tamanyo" => 33580 ] ] "descripcion" => array:1 [ "en" => "The proportions of cells (%) in the nasal lavage fluid of the traffic-controllers and office-workers. The data were analyzed by the Kruskal-Wallis test." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Thamires Marques de Lima, Cristiane Mayumi Kazama, Andreas Rembert Koczulla, Pieter S. Hiemstra, Mariangela Macchione, Ana Luisa Godoy Fernandes, Ubiratan de Paula Santos, Maria Lucia Bueno-Garcia, Dirce Maria Zanetta, Carmen Diva Saldiva de André, Paulo Hilario Nascimento Saldiva, Naomi Kondo Nakagawa" "autores" => array:12 [ 0 => array:2 [ "nombre" => "Thamires Marques" "apellidos" => "de Lima" ] 1 => array:2 [ "nombre" => "Cristiane Mayumi" "apellidos" => "Kazama" ] 2 => array:2 [ "nombre" => "Andreas Rembert" "apellidos" => "Koczulla" ] 3 => array:2 [ "nombre" => "Pieter S." "apellidos" => "Hiemstra" ] 4 => array:2 [ "nombre" => "Mariangela" "apellidos" => "Macchione" ] 5 => array:2 [ "nombre" => "Ana Luisa Godoy" "apellidos" => "Fernandes" ] 6 => array:2 [ "nombre" => "Ubiratan" "apellidos" => "de Paula Santos" ] 7 => array:2 [ "nombre" => "Maria Lucia" "apellidos" => "Bueno-Garcia" ] 8 => array:2 [ "nombre" => "Dirce Maria" "apellidos" => "Zanetta" ] 9 => array:2 [ "nombre" => "Carmen Diva Saldiva" "apellidos" => "de André" ] 10 => array:2 [ "nombre" => "Paulo Hilario Nascimento" "apellidos" => "Saldiva" ] 11 => array:2 [ "nombre" => "Naomi Kondo" "apellidos" => "Nakagawa" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S180759322202035X?idApp=UINPBA00004N" "url" => "/18075932/0000006800000012/v1_202212011241/S180759322202035X/v1_202212011241/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "CLINICAL SCIENCE" "titulo" => "The impact of metabolic syndrome on metabolic, pro-inflammatory and prothrombotic markers according to the presence of high blood pressure criterion" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1495" "paginaFinal" => "1501" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Juliana S. Gil, Luciano F. Drager, Grazia M. Guerra-Riccio, Cristiano Mostarda, Maria C. Irigoyen, Valeria Costa-Hong, Luiz A. Bortolotto, Brent M. Egan, Heno F. Lopes" "autores" => array:9 [ 0 => array:3 [ "nombre" => "Juliana S." "apellidos" => "Gil" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] ] ] 1 => array:3 [ "nombre" => "Luciano F." "apellidos" => "Drager" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "Grazia M." "apellidos" => "Guerra-Riccio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "Cristiano" "apellidos" => "Mostarda" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "Maria C." "apellidos" => "Irigoyen" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] ] ] 5 => array:3 [ "nombre" => "Valeria" "apellidos" => "Costa-Hong" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] ] ] 6 => array:3 [ "nombre" => "Luiz A." "apellidos" => "Bortolotto" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] ] ] 7 => array:3 [ "nombre" => "Brent M." "apellidos" => "Egan" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "II" "identificador" => "aff2" ] ] ] 8 => array:4 [ "nombre" => "Heno F." "apellidos" => "Lopes" "email" => array:1 [ 0 => "hipheno@incor.usp.br" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "I," "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "III" "identificador" => "aff3" ] 2 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Faculdade de Medicina da Universidade de São Paulo, Heart Institute (InCor), São Paulo/SP, Brazil." "etiqueta" => "I" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Medical University of South Carolina, Charleston/SC, USA." "etiqueta" => "II" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Universidade Nove de Julho – UNINOVE, São Paulo/SP, Brazil." "etiqueta" => "III" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Tel.: 55 11 2661-5084" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 564 "Ancho" => 795 "Tamanyo" => 39832 ] ] "descripcion" => array:1 [ "en" => "Flow diagram used to screen patients." ] ] ] "textoCompleto" => "INTRODUCTIONIn 1988, the cardiovascular risk factor cluster, which includes obesity, increased blood pressure, high triglycerides and glucose and low HDL (high-density lipoprotein)-cholesterol, was given the name “metabolic syndrome” (MetS) (<a class="elsevierStyleCrossRef" href="#bib1">1</a>). Since then, the scientific community has tried to better define whether MetS predicts cardiovascular morbidity and mortality better than the sum of the individual components and whether one component is pivotal over the others. Most evidence points to visceral obesity and insulin resistance as central features of MetS. Little attention has been given to exploring other components of MetS, such as blood pressure and the potential factors that can influence not only blood pressure but also the metabolic dysregulation observed in MetS.Obesity-related sympathetic activation is an attractive explanation for several components of MetS. In particular, in 1994, the aggregation of cardiovascular risk factors and signs of a hyper sympathetic state was demonstrated in the Tecumseh population (<a class="elsevierStyleCrossRef" href="#bib2">2</a>). Indeed, increased sympathetic activity (faster heart rate, higher cardiac output and plasma noradrenaline) correlated with higher levels of glucose, insulin, cholesterol, triglycerides, body weight and hematocrit and lower levels of HDL-cholesterol. In the Framingham Heart Study (<a class="elsevierStyleCrossRef" href="#bib3">3</a>), more than 50% of hypertensive patients had 2 or more metabolic abnormalities. Only 19% of males and 17% of females had isolated hypertension. In view of this finding, the name hypertensive syndrome had been used in the past (<a class="elsevierStyleCrossRef" href="#bib4">4</a>). However, it is not clear whether the increase in blood pressure is associated with exacerbations of the metabolic, proinflammatory, prothrombotic, vascular and autonomic dysfunctions in patients with MetS.Evidence suggests that autonomic dysregulation also contributes to elevated blood pressure and metabolic abnormalities. Moreover, α1-adrenoceptor antagonists lower blood pressure, improve insulin sensitivity and ameliorate dyslipidemia (<a class="elsevierStyleCrossRef" href="#bib5">5</a>). However, it is unclear whether autonomic dysregulation in metabolic syndrome is associated not only with hemodynamic impairment but also with metabolic, inflammatory and other abnormalities associated with the syndrome. We hypothesized that high blood pressure, which may reflect increased sympathetic activity, is independently associated with metabolic dysregulation and inflammation in patients with MetS.METHODSStudy populationThis research was performed at the Heart Institute (InCor) at the University of São Paulo Medical School. Over a 1-year period, we initially evaluated 135 consecutive overweight or obese patients from the São Paulo metropolitan area. From this group, we selected 75 patients with MetS, diagnosed according to ATP III (Third Report of the Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults criteria, and with at least three of the following criteria: high blood pressure - arterial blood pressure ≥130 and/or ≥85 mmHg for systolic and diastolic blood pressure, respectively; high glucose - fasting glucose ≥100 mg/dL; increased waist circumference - ≥102 cm in men and ≥88 in women; increased triglycerides - ≥150 mg/dL; decreased HDL - <40 mg/dL in men and <50 mg/mg/dL in women) (<a class="elsevierStyleCrossRef" href="#bib6">6</a>). We excluded patients with morbid obesity (body mass index ≥40 kg/m2), severe hypertension (BP >180/110 mmHg), under regular physical activity, secondary forms of hypertension, diabetes, smokers, patients with any chronic disease and regularly using medications (including antihypertensives, see <a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a>). The patients were divided into 2 groups according to blood pressure status (patients with MetS without high blood pressure, i.e., <130/<85 mmHg: MetS-BP) and (patients with MetS with high blood pressure, i.e., ≥130 systolic and/or ≥85 mmHg diastolic: MetS+BP).<elsevierMultimedia ident="fig1"></elsevierMultimedia>Clinical evaluationPatients who fulfilled the criteria for the study underwent a medical history evaluation. Blood pressure was measured in triplicate after 5 minutes of seated rest using a calibrated sphygmomanometer by the same investigator (J.S.G). The average from 3 blood pressure values was used to define the presence or absence of the ATP III, the criterion used to define elevated blood pressure (≥130 or ≥85 mmHg for systolic and diastolic blood pressure levels, respectively). Fasting blood samples were drawn for biochemical tests and cytokine levels. Serum and plasma were obtained and then stored at -80°C. During the second visit, anthropometric measurements (body mass index – BMI; waist and hip circumferences; and bicipital, tricipital, subscapular and suprailiac skinfolds) and fat mass, lean mass, basal metabolism and total body water were measured using bioimpedance-measuring equipment (BIA 450, Bio dynamics, Seattle, USA) (<a class="elsevierStyleCrossRef" href="#bib7">7</a>).Biochemistry measurementsTotal cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, uric acid, glucose and creatinine levels were measured using commercial kits.Insulin resistanceInsulin resistance was measured using the following 2 methods: the traditional Homeostasis Model Assessment Insulin Resistance method (HOMA-IR) and the Retinol-Binding Protein 4 method (RBP4). The HOMA-IR index was calculated as [fasting serum glucose (mmol/L) x fasting serum insulin (UI/mL)]/22.5.CytokinesCytokines, including total adiponectin, resistin, leptin, insulin, interleukin 6 (IL-6), tumoral necrosis factor alpha (TNF-α), plasminogen activator inhibitor 1 (PAI-1) and monocyte chemoattractant protein 1 (MCP-1), were measured using a multiplex sandwich enzyme-linked immunosorbent assay (ELISA, Millipore, MA, USA) (<a class="elsevierStyleCrossRef" href="#bib8">8</a>).Power spectral analysisThe data for spectral analysis were derived from a finger pulse contour recorded by beat-to-beat blood pressure measurements (Finometer®, FMS, Finapres Medical System BV, Holland) and from the electrocardiogram (ECG) for 10 minutes to characterize the RR interval series. Power spectral density was obtained by the fast Fourier transformation, using Welch's method with a Hanning window of 512 points and 50% overlap as previously described (<a class="elsevierStyleCrossRef" href="#bib9">9</a>). The entire time, series were previously re-sampled at 5.0 Hz to be equally spaced in time by a special signal editor developed for Matlab (MATLAB 6.0; Mathworks, Natick, Massachusetts, USA). Interpolated time series were decimated to be equally time-spaced. Two main components were considered for the RR interval variability: low frequency (LF; 0.04 to 0.15 Hz) and high frequency (HF; 0.15 to 0.4 Hz). The power density of each spectral component from the RR interval was calculated in absolute values and normalized units. The normalized units were obtained by calculating the percentages of LF variability (LFms2) and HF variability (HFms2) with respect to the total power after subtracting the power of very low frequency components (VLF; frequencies of <0.04 Hz). The LF/HF ratio was also calculated to evaluate the sympathovagal balance. In addition, we also evaluated the power spectral analysis of systolic BP. Systolic BP spectral powers were quantified in the LF component (0.04–0.15 Hz) and were reported in absolute units. LF of systolic BP has been associated as a reliable marker of sympathetic activity (<a class="elsevierStyleCrossRef" href="#bib10">10</a>).Baroreflex sensitivityBeat-to-beat values of systolic BP and RR interval were used to estimate the cardiac baroreflex sensitivity (BRS) by spectral analysis, using the alpha index for the low-frequency band (0.04 to 0.15 Hz). The coherence between the RR interval and the systolic BP signal variability was assessed by cross-spectral analysis. The alpha index was calculated only when the magnitude of the squared coherence between the RR and systolic BP signals exceeded 0.5 (range 0–1) in the LF band. After coherence calculation, the alpha index was obtained from the square root of the ratio between RR and systolic BP variability in the 2 major LF bands (<a class="elsevierStyleCrossRefs" href="#bib10">10-13</a>).Anxiety and depression evaluationWe performed the Hamilton Scale to assess anxiety (<a class="elsevierStyleCrossRefs" href="#bib14">14-15</a>) and the Beck questionnaire to assess depression (<a class="elsevierStyleCrossRef" href="#bib16">16</a>).Statistical analysisThe SPSS software (SPSS 10.0, Chicago, IL) was used for statistical calculations. Data were expressed as the means±standard deviations, medians or percentages, as indicated. The Kolmogorov-Smirnov test was used to assess the normality of distribution of each variable studied. Categorical variables (sex, race and percentage of MetS components) were compared using Fisher's test. Numerical variables were compared using the unpaired Student's t test. Logistic regression analysis (forward model) was used to identify the metabolic, pro-inflammatory and prothrombotic markers that were independently associated with the MetS+BP. The model was controlled for age and BMI. ANOVA was used to select variables for the logistic regression analysis. All variables with a p<0.1 in the univariate analysis were selected for the final model. P<0.05 was considered to be statistically significant.Ethics statementThe local ethics committee (Institutional Review Board – Heart Institute) approved the protocol, which was in accordance with the ethical standards and with the Helsinki Declaration of 1975, and all participants gave written informed consent.RESULTS<a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a> depicts derivation of the study sample of 75 subjects from the initial sample of 135 patients with MetS. The percentage of each MetS criterion is reported in the supplemental file.Baseline descriptive data on the MetS patients without (N = 45) and with (N = 30) high blood pressure are provided in <a class="elsevierStyleCrossRef" href="#t1-cln_68p1495">Table 1</a>. We observed a significant trend for increasing age in the MetS+BP group. There was no significant difference in gender, % of Caucasians and anthropometric data, including body mass index, waist circumference, hip circumference, waist-to-hip ratio, fat percentage as calculated by skinfold, fat mass, lean mass, metabolic tax and total body water estimated by bioelectrical impedance analysis (BIA) (<a class="elsevierStyleCrossRef" href="#t1-cln_68p1495">Table 1</a>). As expected, there were significant differences in the systolic and diastolic blood pressure measurements between groups. Pulse intervals during spectral analysis were significantly lower (heart rate faster) in the MetS+BP compared to the MetS-BP group (<a class="elsevierStyleCrossRef" href="#t2-cln_68p1495">Table 2</a>). The LF components for heart rate and blood pressure and the LF/HF ratio were significantly higher in the MetS+BP group than in the MetS-BP group. Baroreflex sensitivity, as evaluated by the alpha index, was impaired in the MetS+BP group compared with the MetS-BP group. No differences were detected between groups with regards to anxiety and depression (supplemental file).<elsevierMultimedia ident="t1-cln_68p1495"></elsevierMultimedia><elsevierMultimedia ident="t2-cln_68p1495"></elsevierMultimedia>Biochemistry data (glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, uric acid and creatinine), along with insulin and the HOMA-IR index, were significantly higher in the MetS+BP group than in the MetS-BP group (<a class="elsevierStyleCrossRef" href="#t3-cln_68p1495">Table 3</a>).<elsevierMultimedia ident="t3-cln_68p1495"></elsevierMultimedia>RBP4 was significantly higher in the MetS+BP group than the MetS-BP group (<a class="elsevierStyleCrossRef" href="#fig2">Figure 2A</a>). Leptin, resistin and TNF-α levels did not differ between the MetS+BP group (49.4±41.5 pg/mL, 12.6±4.6 pg/mL and 4.8±1.7 ng/mL, respectively) and the MetS-BP group (41.4±20.0 pg/mL, 12.9±4.9 pg/mL and 4.4±1.4 ng/mL, respectively). IL-6, PAI-1 and MCP-1, a marker for inflammatory activity, were significantly higher in the MetS+BP group (<a class="elsevierStyleCrossRef" href="#fig2">Figures 2B-2D</a>). Adiponectin was lower in the MetS+BP group compared to the MetS-BP group (<a class="elsevierStyleCrossRef" href="#fig2">Figure 2E</a>). The differences in RBP4, PAI-1, IL-6, MCP-1 and adiponectin levels between groups remained significant after adjusting for age and sex.<elsevierMultimedia ident="fig2"></elsevierMultimedia>Logistic regression analysis indicated that HDL, RBP-4 and PAI-1 levels were independently associated with MetS+BP. There was a strong trend for an independent association between MetS+BP and glucose levels (<a class="elsevierStyleCrossRef" href="#t4-cln_68p1495">Table 4</a>).<elsevierMultimedia ident="t4-cln_68p1495"></elsevierMultimedia>DISCUSSIONPrevious studies have shown that patients with MetS have multiple abnormalities that contribute to increased cardiovascular risk, including metabolic, proinflammatory, prothrombotic and autonomic variables (<a class="elsevierStyleCrossRefs" href="#bib17">17-19</a>). We hypothesized that MetS patients with elevated blood pressure may have greater abnormalities in these same variables. By stratifying patients with similar obesity levels according to the presence or absence of high blood pressure, we found that those with high blood pressure (MetS+BP) had higher surrogate markers of sympathetic activity derived from spectral analysis and greater impairment in several components of MetS, including higher glucose and triglycerides and lower HDL-cholesterol. The MetS group with high blood pressure also had higher values for other risk factors, including total cholesterol, LDL-cholesterol, uric acid and insulin, along with HOMA index and RBP4, which are associated with insulin resistance (<a class="elsevierStyleCrossRef" href="#bib17">17</a>,<a class="elsevierStyleCrossRef" href="#bib20">20</a>,<a class="elsevierStyleCrossRef" href="#bib21">21</a>). In addition, several markers of inflammatory and prothrombotic activity, including IL-6, PAI-1 and MCP-1, were higher, while adiponectin levels were lower in patients with MetS and high blood pressure. Finally, we found that HDL-cholesterol, RBP4 and PAI-1 were independently associated with MetS+BP. Taken together, our results suggest a significant heterogeneity of the MetS in promoting metabolic, pro-inflammatory, prothrombotic and autonomic impairments.MetS was defined based on the observation that a number of interrelated characteristics and diseases tended to cluster in the same individual and contributed to increased cardiovascular risk. However, MetS is not a well-defined pathophysiological entity, and the diagnostic criteria are variable and based on expert opinions (<a class="elsevierStyleCrossRef" href="#bib22">22</a>). The literature has debated the existence of a major trigger for MetS and its components or whether the whole is really greater than the sum of the parts. Obesity emerges as an attractive candidate to explain all manifestations of MetS, but the best way to measure this parameter in the MetS scenario is also debatable. Some studies identified an association between abdominal obesity (waist circumference) and components of MetS (<a class="elsevierStyleCrossRef" href="#bib23">23</a>,<a class="elsevierStyleCrossRef" href="#bib24">24</a>), while others showed an association with body mass index or waist-to-hip ratio (<a class="elsevierStyleCrossRefs" href="#bib25">25-28</a>). Regardless of the obesity parameter, the importance of obesity in inducing high blood pressure and metabolic and inflammatory dysregulation is clear.Elevated sympathetic nervous system activity seems to be crucial to the development of obesity-related risk (<a class="elsevierStyleCrossRef" href="#bib29">29</a>). In our study, patients with MetS and high blood pressure had higher surrogate markers of sympathetic activity. Long-term sympathetic activation can lead to small artery vasoconstriction and remodeling, which increases the wall-to-lumen ratio and may act synergistically with large artery damage to raise blood pressure (<a class="elsevierStyleCrossRef" href="#bib30">30</a>). Sympathetic activity is also related to baroreflex impairment, as observed in this study. However, sympathetic activity may not be related only to hemodynamic impairment but also to metabolic and inflammatory dysregulation.In addition to the hemodynamic effects, sympathetically mediated vasoconstriction may also antagonize insulin-mediated glucose uptake (<a class="elsevierStyleCrossRef" href="#bib29">29</a>). This theory is supported by longitudinal studies demonstrating that elevated indices of sympathetic activation precede the development of insulin resistance (<a class="elsevierStyleCrossRef" href="#bib31">31</a>). Jamerson et al. showed that norepinephrine infusion, but not angiotensin, impaired insulin-stimulated glucose uptake (<a class="elsevierStyleCrossRefs" href="#bib29">29-31</a>). In line with the metabolic dysregulation observed in our study, Lichtand et al. found that autonomic nervous system dysregulation was strongly associated with MetS and its components in a large cohort of participants aged 18-65 years (<a class="elsevierStyleCrossRef" href="#bib35">35</a>). However, these authors did not stratify patients with MetS according to blood pressure status and did not explore other risk factors not included in the MetS definition, such as proinflammatory and prothrombotic markers.In our study, we also observed that adiponectin levels were lower and that markers of inflammation were higher in MetS patients with high blood pressure than in MetS patients without high blood pressure. Sympathetic activation reportedly reduces adiponectin release, whereas central-sympathetic blockade may increase adiponectin levels (<a class="elsevierStyleCrossRef" href="#bib36">36</a>). Plasma adiponectin is inversely related to insulin resistance (<a class="elsevierStyleCrossRef" href="#bib35">35</a>). Thus, the increased sympathetic activity in patients with MetS and high blood pressure may decrease adiponectin levels that, in turn, can also contribute to insulin resistance. Systemic inflammation may also be linked to sympathetic activity. Previous evidence found that indirect markers of sympathetic activity (increased heart rate and reduced heart-rate variability) were associated with subclinical inflammation in healthy middle-aged and elderly subjects. These results suggest that an autonomic imbalance in favor of the sympathetic system may interact with inflammatory processes to play a more important role in the process of vascular stiffness and atherosclerosis.A few limitations from this investigation should be addressed. First, due to the study design, our findings suggest an association rather than a cause-effect relationship between high blood pressure and metabolic, inflammatory, prothrombotic and autonomic impairments in patients with MetS. Although consistent with the cited literature, we cannot prove that sympathetic activity is the main obesity-related trigger underlying not only the increased blood pressure but also impairments in the metabolic, inflammatory and prothrombotic profiles in this subgroup of patients with MetS. Second, direct measurements of peripheral sympathetic activity using microneurography were not performed. However, spectral analysis is an acceptable non-invasive method for estimating sympathovagal activity (<a class="elsevierStyleCrossRef" href="#bib13">13</a>). Our findings consistently suggest a decrease in vagal activity and the activation of the sympathetic system in the spectral analyses of both heart rate and blood pressure. Third, these results cannot be extrapolated to MetS patients with diabetes. Finally, the precise reasons by which a subset of patients with MetS had higher blood pressure and greater sympathetic activity despite similar indices of obesity are not clear. Recent studies reported the potential role of psychosocial stress in inducing sympathetic activity (<a class="elsevierStyleCrossRef" href="#bib29">29</a>,<a class="elsevierStyleCrossRef" href="#bib37">37</a>,<a class="elsevierStyleCrossRef" href="#bib38">38</a>). Another potential candidate is obstructive sleep apnea. This clinical condition is characterized by sympathetic activation that is independent of obesity, and it is a well-established cause of high blood pressure and increased arterial stiffness (<a class="elsevierStyleCrossRefs" href="#bib39">39-41</a>). Recent evidence in consecutive patients with MetS suggests that obstructive sleep apnea is quite common and is independently associated with increased sympathetic activity (<a class="elsevierStyleCrossRef" href="#bib41">41</a>), metabolic and inflammatory dysregulation (<a class="elsevierStyleCrossRef" href="#bib42">42</a>) and increased markers of atherosclerosis (<a class="elsevierStyleCrossRef" href="#bib43">43</a>). These potential confounders should be addressed in future investigations.In conclusion, this study provides several provocative new findings that suggest the importance of characterizing patients with MetS according to the presence or absence of high blood pressure. Although we cannot prove a cause-effect relationship, our results demonstrated that patients with MetS and high blood pressure have higher surrogate markers of sympathetic activity and significant metabolic, inflammatory and prothrombotic impairments. Thus, it is reasonable to speculate that blocking sympathetic activity is an attractive strategy for treating patients with MetS. A previous study showed that a combined α- and β-adrenergic blockade significantly reduced blood pressure in obese patients compared to lean patients with essential hypertension (<a class="elsevierStyleCrossRef" href="#bib44">44</a>). Moreover, renal denervation, which reduces sympathetic activity, lowers blood pressure and reduces insulin resistance, may improve obstructive sleep apnea (<a class="elsevierStyleCrossRef" href="#bib45">45</a>). Future studies will clarify whether pharmacological suppression of sympathetic activity in patients with MetS will improve not only blood pressure but also the metabolic, inflammatory and prothrombotic dysfunctions observed in these patients.ACKNOWLEDGMENTSThis work was supported by grants from FAPESP (Fundação de Amparo à Pesquisa de São Paulo) and Zerbini Foundation." "textoCompletoSecciones" => array:1 [ "secciones" => array:7 [ 0 => array:2 [ "identificador" => "xpalclavsec1582062" "titulo" => "KEYWORDS" ] 1 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 2 => array:3 [ "identificador" => "cesec20" "titulo" => "METHODS" "secciones" => array:10 [ 0 => array:2 [ "identificador" => "cesec30" "titulo" => "Study population" ] 1 => array:2 [ "identificador" => "cesec40" "titulo" => "Clinical evaluation" ] 2 => array:2 [ "identificador" => "cesec50" "titulo" => "Biochemistry measurements" ] 3 => array:2 [ "identificador" => "cesec60" "titulo" => "Insulin resistance" ] 4 => array:2 [ "identificador" => "cesec70" "titulo" => "Cytokines" ] 5 => array:2 [ "identificador" => "cesec80" "titulo" => "Power spectral analysis" ] 6 => array:2 [ "identificador" => "cesec90" "titulo" => "Baroreflex sensitivity" ] 7 => array:2 [ "identificador" => "cesec100" "titulo" => "Anxiety and depression evaluation" ] 8 => array:2 [ "identificador" => "cesec110" "titulo" => "Statistical analysis" ] 9 => array:2 [ "identificador" => "cesec120" "titulo" => "Ethics statement" ] ] ] 3 => array:2 [ "identificador" => "cesec130" "titulo" => "RESULTS" ] 4 => array:2 [ "identificador" => "cesec140" "titulo" => "DISCUSSION" ] 5 => array:2 [ "identificador" => "cesec150" "titulo" => "ACKNOWLEDGMENTS" ] 6 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2013-04-27" "fechaAceptado" => "2013-06-11" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1582062" "palabras" => array:6 [ 0 => "Hypertension" 1 => "Sympathetic Activity" 2 => "Insulin Resistance" 3 => "Inflammation" 4 => "Prothrombosis" 5 => "Metabolic Syndrome" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "OBJECTIVES:We explored whether high blood pressure is associated with metabolic, inflammatory and prothrombotic dysregulation in patients with metabolic syndrome. METHODS:We evaluated 135 consecutive overweight/obese patients. From this group, we selected 75 patients who were not under the regular use of medications for metabolic syndrome as defined by the current Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults criteria. The patients were divided into metabolic syndrome with and without high blood pressure criteria (≥130/≥85 mmHg). RESULTS:Compared to the 45 metabolic syndrome patients without high blood pressure, the 30 patients with metabolic syndrome and high blood pressure had significantly higher glucose, insulin, homeostasis model assessment insulin resistance index, total cholesterol, low-density lipoprotein-cholesterol, triglycerides, uric acid and creatinine values; in contrast, these patients had significantly lower high-density lipoprotein-cholesterol values. Metabolic syndrome patients with high blood pressure also had significantly higher levels of retinol-binding protein 4, plasminogen activator inhibitor 1, interleukin 6 and monocyte chemoattractant protein 1 and lower levels of adiponectin. Moreover, patients with metabolic syndrome and high blood pressure had increased surrogate markers of sympathetic activity and decreased baroreflex sensitivity. Logistic regression analysis showed that high-density lipoprotein, retinol-binding protein 4 and plasminogen activator inhibitor-1 levels were independently associated with metabolic syndrome patients with high blood pressure. There is a strong trend for an independent association between metabolic syndrome patients with high blood pressure and glucose levels. CONCLUSIONS:High blood pressure, which may be related to the autonomic dysfunction, is associated with metabolic, inflammatory and prothrombotic dysregulation in patients with metabolic syndrome." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "ceabs10" "titulo" => "OBJECTIVES:" ] 1 => array:2 [ "identificador" => "ceabs20" "titulo" => "METHODS:" ] 2 => array:2 [ "identificador" => "ceabs30" "titulo" => "RESULTS:" ] 3 => array:2 [ "identificador" => "ceabs40" "titulo" => "CONCLUSIONS:" ] ] ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "Gil JS conceived, designed and performed the experiments; analysed the data and wrote the paper. Drager LF and Lopes HF conceived and designed the experiments, analysed the data and wrote the paper. Mostarda C performed the experiments and analysed the data. Guerra-Riccio GM and Costa-Hong V performed the experiments. Irigoyen MC and Bortolotto LA analysed the data. Egan BM wrote the paper. No potential conflict of interest was reported." ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 564 "Ancho" => 795 "Tamanyo" => 39832 ] ] "descripcion" => array:1 [ "en" => "Flow diagram used to screen patients." ] ] 1 => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 309 "Ancho" => 729 "Tamanyo" => 11480 ] ] "descripcion" => array:1 [ "en" => "Retinol-binding protein 4 levels (2A), plasminogen activator inhibitor 1 levels (2B), interleukin 6 levels (2C), monocyte chemoattractant protein 1 levels (2D) and adiponectin levels (2E) in metabolic syndrome - blood pressure and metabolic syndrome + blood pressure subjects. The results are presents as the means±SD." ] ] 2 => array:7 [ "identificador" => "t1-cln_68p1495" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "BMR = basal metabolic rate; TBW = Total body water." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Variables \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">MetS-BP (n = 45) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">MetS+BP (n = 30) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">p-value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38±11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">45±9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.061 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sex (F/M) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">34/11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19/11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.843 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Caucasians, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">32 (71%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20 (67%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.789 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Systolic BP (mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">121±10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">144±18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Diastolic BP (mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">76±8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">90±13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Heart Rate (bpm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">72±9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">77±12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.081 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Body mass index (kg/m2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">32.2±4.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">32.5±4.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.767 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Waist circumference (cm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">108±10 (men)/100±11 (women) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">111±12 (men)/101±11 (women) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.6 (men) 0.7 (women) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Waist-to-hip ratio \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.93±0.06 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.95±0.08 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.265 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fat (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">32±6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">32±7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.817 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fat mass (BIA), % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28±7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28±9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.878 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lean mass (BIA), % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">59±10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">60±13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.534 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BMR (BIA), kcal \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,829±328 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1,842±398 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.743 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TBW (BIA), % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">43±8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">44±10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.73 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Demographic, hemodynamic and anthropometric (clinical and bioimpedance) data (means±sd) in metabolic syndrome patients without blood pressure criterion (metabolic syndrome - blood pressure) or with blood pressure (metabolic syndrome + blood pressure)." ] ] 3 => array:7 [ "identificador" => "t2-cln_68p1495" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "PI = Pulse interval; VAR PI = Variance of PI; LF = low frequency; HF = High frequency; SBP = Systolic blood pressure; VAR SBP = Variance of SBP." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Variable \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">MetS-BP \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">MetS+BP \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">p-value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="justify" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PI (ms) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">887±120 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">823±126 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="justify" valign="\n \t\t\t\t\ttop\n \t\t\t\t">VAR PI (ms2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2653±1910 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2578±1529 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="justify" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LF (ms2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">638±607 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">671±498 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="justify" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HF (ms2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">687±563 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">590±549 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="justify" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LF (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">48±15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">56±13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.04 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="justify" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HF (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">52±15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">44±13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.04 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="justify" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LF/HF \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0±0.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.5±0.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.08 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="justify" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SBP (mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">126±13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">141±21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.003 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="justify" valign="\n \t\t\t\t\ttop\n \t\t\t\t">VAR SBP (mmHg2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35±25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50±25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.03 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="justify" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LF (mmHg2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.7±4.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.0±9.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="justify" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Alpha index (ms/mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.4±5.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.7±3.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.04 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Power spectral analysis in metabolic syndrome patients without blood pressure criterion (metabolic syndrome - blood pressure) or with blood pressure criterion (metabolic syndrome + blood pressure)." ] ] 4 => array:7 [ "identificador" => "t3-cln_68p1495" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "HDL = High-density lipoprotein; LDL = Low-density lipoprotein; HOMA-ir = homeostasis model assessment-estimated insulin resistance index (means±sd). Triglycerides values are reported as the medians (interquartile ranges)." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Variables \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">MetS-BP (n = 45) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">MetS+BP (n = 30) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">p-value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Glucose (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">97±8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">102±7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.013 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Insulin (U/mL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.5±3.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21.5±20.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.007 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HOMA-ir \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.5±1.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.4±5.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.006 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">T-cholesterol (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">194±33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">221±43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HDL-cholesterol (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">40.3±5.9 (men)/51.5±10.6 (women) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38.3±6.6 (men)/42.6±7.6 (women) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.5 (men) 0.002 (women) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">119±27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">145±39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.002 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Triglycerides (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">150±36 (men)/124±54 (women) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">190±78 (men)/167±57 (women) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.2 (men) 0.07 (women) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Uric Acid (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.6±1.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.6±1.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Creatinine (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.8±0.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0±0.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.008 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Biochemical data from metabolic syndrome patients without blood pressure criterion (metabolic syndrome - blood pressure) or with blood pressure criterion (metabolic syndrome + blood pressure)." ] ] 5 => array:7 [ "identificador" => "t4-cln_68p1495" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Variables \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">B \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Sig. \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">OR \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">95% C.I. for OR</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Lower \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Upper \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GLIC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.118 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.057 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.125 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.996 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.270 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HDL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-0.147 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.008 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.863 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.775 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.962 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">RBP4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.507 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.511 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.909 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.663 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PAI1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.270 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.002 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.311 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.103 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.558 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Constant \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-20.148 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.011 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Logistic regression analysis for variables independently associated with metabolic syndrome with high blood pressure (metabolic syndrome + blood pressure)" ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:45 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Banting lecture 1988. Role of insulin resistance in human disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ GM Reaven \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2337/diab.37.12.1595" "Revista" => array:7 [ "tituloSerie" => "Diabetes" "fecha" => "1988" "volumen" => "37" "numero" => "12" "paginaInicial" => "1595" "paginaFinal" => "1607" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3056758" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hematocrit levels and physiologic factors in relationship to cardiovascular risk in Tecumseh, Michigan" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ S Smith \n \t\t\t\t\t\t\t\t """ 1 => """ S Julius \n \t\t\t\t\t\t\t\t """ 2 => """ K Jamerson \n \t\t\t\t\t\t\t\t """ 3 => """ J Amerena \n \t\t\t\t\t\t\t\t """ 4 => """ N Schork \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Hypertens" "fecha" => "1994" "volumen" => "12" "numero" => "4" "paginaInicial" => "455" "paginaFinal" => "462" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8064170" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk stratification in hypertension: new insights from the Framingham Study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ WB Kannel \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0895-7061(99)00252-6" "Revista" => array:7 [ "tituloSerie" => "Am J Hypertens" "fecha" => "2000" "volumen" => "13" "numero" => "1Pt 2" "paginaInicial" => "3S" "paginaFinal" => "10S" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10678282" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "New insights and approaches to reduce end-organ damage in the treatment of hypertension: subsets of hypertension approach" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ MC Houston \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/0002-8703(92)91042-y" "Revista" => array:7 [ "tituloSerie" => "Am Heart J" "fecha" => "1992" "volumen" => "123" "numero" => "5" "paginaInicial" => "1337" "paginaFinal" => "1367" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1575152" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Time to re-appraise the role of alpha-1 adrenoceptor antagonists in the management of hypertension?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ N Chapman \n \t\t\t\t\t\t\t\t """ 1 => """ CY Chen \n \t\t\t\t\t\t\t\t """ 2 => """ T Fujita \n \t\t\t\t\t\t\t\t """ 3 => """ FD Hobbs \n \t\t\t\t\t\t\t\t """ 4 => """ SJ Kim \n \t\t\t\t\t\t\t\t """ 5 => """ JA Staessen \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1097/HJH.0b013e32833b912c" "Revista" => array:6 [ "tituloSerie" => "J Hypertens" "fecha" => "2010" "volumen" => "28" "paginaInicial" => "1796" "paginaFinal" => "1803" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20543713" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1097/HJH.0b013e32833b912c" "Revista" => array:4 [ "tituloSerie" => "J Hypertens" "fecha" => "2010" "volumen" => "28" "numero" => "11" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Circulation" "fecha" => "2002" "volumen" => "106" "numero" => "25" "paginaInicial" => "3143" "paginaFinal" => "3421" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12485966" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bioelectric impedance overestimates the body fat in overweight and underestimates in Brazilian obese women: a comparison with Segal equation 1" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ GD Pimentel \n \t\t\t\t\t\t\t\t """ 1 => """ AB Bernhard \n \t\t\t\t\t\t\t\t """ 2 => """ MR Frezza \n \t\t\t\t\t\t\t\t """ 3 => """ AE Rinaldi \n \t\t\t\t\t\t\t\t """ 4 => """ RC Burini \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Nutr Hosp" "fecha" => "2010" "volumen" => "25" "numero" => "5" "paginaInicial" => "741" "paginaFinal" => "745" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21336430" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ HS Schipper \n \t\t\t\t\t\t\t\t """ 1 => """ W de Jager \n \t\t\t\t\t\t\t\t """ 2 => """ ME van Dijk \n \t\t\t\t\t\t\t\t """ 3 => """ J Meerding \n \t\t\t\t\t\t\t\t """ 4 => """ PM Zelissen \n \t\t\t\t\t\t\t\t """ 5 => """ RA Adan \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1373/clinchem.2010.146118" "Revista" => array:8 [ "tituloSerie" => "Clin Chem" "fecha" => "2010" "volumen" => "56" "numero" => "8" "paginaInicial" => "1320" "paginaFinal" => "1328" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20530731" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0092867421006279" "estado" => "S300" "issn" => "00928674" ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sleep-related changes in hemodynamic and autonomic regulation in human hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ LF Drager \n \t\t\t\t\t\t\t\t """ 1 => """ LM Ueno \n \t\t\t\t\t\t\t\t """ 2 => """ PS Lessa \n \t\t\t\t\t\t\t\t """ 3 => """ CE Negrão \n \t\t\t\t\t\t\t\t """ 4 => """ G Lorenzi-Filho \n \t\t\t\t\t\t\t\t """ 5 => """ EM Krieger \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/HJH.0b013e32832c6982" "Revista" => array:7 [ "tituloSerie" => "J Hypertens" "fecha" => "2009" "volumen" => "27" "numero" => "8" "paginaInicial" => "1655" "paginaFinal" => "1663" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19451834" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ M Pagani \n \t\t\t\t\t\t\t\t """ 1 => """ F Lombardi \n \t\t\t\t\t\t\t\t """ 2 => """ S Guzzetti \n \t\t\t\t\t\t\t\t """ 3 => """ O Rimoldi \n \t\t\t\t\t\t\t\t """ 4 => """ R Furlan \n \t\t\t\t\t\t\t\t """ 5 => """ P Pizzinelli \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.res.59.2.178" "Revista" => array:7 [ "tituloSerie" => "Circ Res" "fecha" => "1986" "volumen" => "59" "numero" => "2" "paginaInicial" => "178" "paginaFinal" => "193" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2874900" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Circulation" "fecha" => "1996" "volumen" => "93" "numero" => "5" "paginaInicial" => "1043" "paginaFinal" => "1065" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8598068" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is reduced baroreflex gain a component of the metabolic syndrome? Insights from the LINOSA study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ D Lucini \n \t\t\t\t\t\t\t\t """ 1 => """ G Cusumano \n \t\t\t\t\t\t\t\t """ 2 => """ A Bellia \n \t\t\t\t\t\t\t\t """ 3 => """ M Kozakova \n \t\t\t\t\t\t\t\t """ 4 => """ G Difede \n \t\t\t\t\t\t\t\t """ 5 => """ R Lauro \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.hjh.0000202817.02836.9c" "Revista" => array:7 [ "tituloSerie" => "J Hypertens" "fecha" => "2006" "volumen" => "24" "numero" => "2" "paginaInicial" => "361" "paginaFinal" => "370" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16508585" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Changes in autonomic regulation induced by physical training in mild hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ M Pagani \n \t\t\t\t\t\t\t\t """ 1 => """ V Somers \n \t\t\t\t\t\t\t\t """ 2 => """ R Furlan \n \t\t\t\t\t\t\t\t """ 3 => """ S Dell'Orto \n \t\t\t\t\t\t\t\t """ 4 => """ J Conway \n \t\t\t\t\t\t\t\t """ 5 => """ G Baselli \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.hyp.12.6.600" "Revista" => array:7 [ "tituloSerie" => "Hypertension" "fecha" => "1988" "volumen" => "12" "numero" => "6" "paginaInicial" => "600" "paginaFinal" => "610" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3203964" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The assessment of anxiety states by rating" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ M Hamilton \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.2044-8341.1959.tb00467.x" "Revista" => array:7 [ "tituloSerie" => "Br J Med Psychol" "fecha" => "1959" "volumen" => "32" "numero" => "1" "paginaInicial" => "50" "paginaFinal" => "55" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13638508" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Hamilton Anxiety Scale: reliability, validity and sensitivity to change in anxiety and depressive disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ W Maier \n \t\t\t\t\t\t\t\t """ 1 => """ R Buller \n \t\t\t\t\t\t\t\t """ 2 => """ M Philipp \n \t\t\t\t\t\t\t\t """ 3 => """ I Heuser \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/0165-0327(88)90072-9" "Revista" => array:8 [ "tituloSerie" => "J Affect Disord" "fecha" => "1988" "volumen" => "14" "numero" => "1" "paginaInicial" => "61" "paginaFinal" => "68" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2963053" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0092867420306723" "estado" => "S300" "issn" => "00928674" ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation of the Brazilian Portuguese version of the Beck Depression Inventory-II in a community sample. Rev" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ MH Gomes-Oliveira \n \t\t\t\t\t\t\t\t """ 1 => """ C Gorenstein \n \t\t\t\t\t\t\t\t """ 2 => """ F Lotufo Neto \n \t\t\t\t\t\t\t\t """ 3 => """ LH Andrade \n \t\t\t\t\t\t\t\t """ 4 => """ YP Wang \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Bras. Psiquiatr" "fecha" => "2012" "volumen" => "34" "numero" => "4" "paginaInicial" => "389" "paginaFinal" => "394" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ TE Graham \n \t\t\t\t\t\t\t\t """ 1 => """ Q Yang \n \t\t\t\t\t\t\t\t """ 2 => """ M Blüher \n \t\t\t\t\t\t\t\t """ 3 => """ A Hammarstedt \n \t\t\t\t\t\t\t\t """ 4 => """ TP Ciaraldi \n \t\t\t\t\t\t\t\t """ 5 => """ RR Henry \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa054862" "Revista" => array:7 [ "tituloSerie" => "N Engl J Med" "fecha" => "2006" "volumen" => "354" "numero" => "24" "paginaInicial" => "2552" "paginaFinal" => "2563" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16775236" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use and abuse of HOMA modeling" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ TM Wallace \n \t\t\t\t\t\t\t\t """ 1 => """ JC Levy \n \t\t\t\t\t\t\t\t """ 2 => """ DR Matthews \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2337/diacare.27.6.1487" "Revista" => array:7 [ "tituloSerie" => "Diabetes Care" "fecha" => "2004" "volumen" => "27" "numero" => "6" "paginaInicial" => "1487" "paginaFinal" => "1495" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15161807" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ SM Grundy \n \t\t\t\t\t\t\t\t """ 1 => """ JI Cleeman \n \t\t\t\t\t\t\t\t """ 2 => """ SR Daniels \n \t\t\t\t\t\t\t\t """ 3 => """ KA Donato \n \t\t\t\t\t\t\t\t """ 4 => """ RH Eckel \n \t\t\t\t\t\t\t\t """ 5 => """ RA Franklin \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/CIRCULATIONAHA.105.169404" "Revista" => array:7 [ "tituloSerie" => "Circulation" "fecha" => "2005" "volumen" => "112" "numero" => "17" "paginaInicial" => "2735" "paginaFinal" => "2752" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16157765" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Waist circumference and not body mass index explains obesity-related health risk" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ I Janssen \n \t\t\t\t\t\t\t\t """ 1 => """ PT Katzmarzyk \n \t\t\t\t\t\t\t\t """ 2 => """ R Ross \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/ajcn/79.3.379" "Revista" => array:8 [ "tituloSerie" => "Am J Clin Nutr" "fecha" => "2004" "volumen" => "79" "numero" => "3" "paginaInicial" => "379" "paginaFinal" => "384" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14985210" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0022202X1830109X" "estado" => "S300" "issn" => "0022202X" ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Waist circumference as a measure for indicating need for weight management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ ME Lean \n \t\t\t\t\t\t\t\t """ 1 => """ TS Han \n \t\t\t\t\t\t\t\t """ 2 => """ CE Morrison \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/bmj.311.6998.158" "Revista" => array:7 [ "tituloSerie" => "BMJ" "fecha" => "1995" "volumen" => "311" "numero" => "6998" "paginaInicial" => "158" "paginaFinal" => "161" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7613427" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Body mass index has a good correlation with proatherosclerotic profile in children and adolescents" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ GB Costa \n \t\t\t\t\t\t\t\t """ 1 => """ N Horta \n \t\t\t\t\t\t\t\t """ 2 => """ ZF Resende \n \t\t\t\t\t\t\t\t """ 3 => """ G Souza \n \t\t\t\t\t\t\t\t """ 4 => """ LM Barreto \n \t\t\t\t\t\t\t\t """ 5 => """ LH Correia \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1590/s0066-782x2009000900010" "Revista" => array:7 [ "tituloSerie" => "Arq Bras Cardiol" "fecha" => "2009" "volumen" => "93" "numero" => "3" "paginaInicial" => "261" "paginaFinal" => "267" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19851654" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Body mass index, waist circumference, and clustering of cardiovascular disease risk factors in a biracial sample of children and adolescents" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ PT Katzmarzyk \n \t\t\t\t\t\t\t\t """ 1 => """ SR Srinivasan \n \t\t\t\t\t\t\t\t """ 2 => """ W Chen \n \t\t\t\t\t\t\t\t """ 3 => """ RM Malina \n \t\t\t\t\t\t\t\t """ 4 => """ C Bouchard \n \t\t\t\t\t\t\t\t """ 5 => """ GS Berenson \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1542/peds.114.2.e198" "Revista" => array:7 [ "tituloSerie" => "Pediatrics" "fecha" => "2004" "volumen" => "114" "numero" => "2" "paginaInicial" => "e198" "paginaFinal" => "e205" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15286257" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ HJ Schneider \n \t\t\t\t\t\t\t\t """ 1 => """ H Glaesmer \n \t\t\t\t\t\t\t\t """ 2 => """ J Klotsche \n \t\t\t\t\t\t\t\t """ 3 => """ S Böhler \n \t\t\t\t\t\t\t\t """ 4 => """ H Lehnert \n \t\t\t\t\t\t\t\t """ 5 => """ AM Zeiher \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jc.2006-0254" "Revista" => array:7 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "2007" "volumen" => "92" "numero" => "2" "paginaInicial" => "589" "paginaFinal" => "594" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17105840" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ S Yusuf \n \t\t\t\t\t\t\t\t """ 1 => """ S Hawken \n \t\t\t\t\t\t\t\t """ 2 => """ S Ounpuu \n \t\t\t\t\t\t\t\t """ 3 => """ L Bautista \n \t\t\t\t\t\t\t\t """ 4 => """ MG Franzosi \n \t\t\t\t\t\t\t\t """ 5 => """ P Commerford \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(05)67663-5" "Revista" => array:7 [ "tituloSerie" => "Lancet" "fecha" => "2005" "volumen" => "366" "numero" => "9497" "paginaInicial" => "1640" "paginaFinal" => "1649" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16271645" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Stress and its role in sympathetic nervous system activation in hypertension and the metabolic syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ EA Lambert \n \t\t\t\t\t\t\t\t """ 1 => """ GW Lambert \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11906-011-0186-y" "Revista" => array:7 [ "tituloSerie" => "Curr Hypertens Rep" "fecha" => "2011" "volumen" => "13" "numero" => "3" "paginaInicial" => "244" "paginaFinal" => "248" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21271362" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanisms of obesity-induced hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ V Kotsis \n \t\t\t\t\t\t\t\t """ 1 => """ S Stabouli \n \t\t\t\t\t\t\t\t """ 2 => """ S Papakatsika \n \t\t\t\t\t\t\t\t """ 3 => """ Z Rizos \n \t\t\t\t\t\t\t\t """ 4 => """ G Parati \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/hr.2010.9" "Revista" => array:7 [ "tituloSerie" => "Hypertens Res" "fecha" => "2010" "volumen" => "33" "numero" => "5" "paginaInicial" => "386" "paginaFinal" => "393" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20442753" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased sympathetic reactivity may predict insulin resistance: an 18-year follow-up study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ A Flaa \n \t\t\t\t\t\t\t\t """ 1 => """ TA Aksnes \n \t\t\t\t\t\t\t\t """ 2 => """ SE Kjeldsen \n \t\t\t\t\t\t\t\t """ 3 => """ I Eide \n \t\t\t\t\t\t\t\t """ 4 => """ M Rostrup \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.metabol.2008.05.012" "Revista" => array:7 [ "tituloSerie" => "Metabolism" "fecha" => "2008" "volumen" => "57" "numero" => "10" "paginaInicial" => "1422" "paginaFinal" => "1427" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18803948" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angiotensin mediates forearm glucose uptake by hemodynamic rather than direct effects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ KA Jamerson \n \t\t\t\t\t\t\t\t """ 1 => """ SD Nesbitt \n \t\t\t\t\t\t\t\t """ 2 => """ JV Amerena \n \t\t\t\t\t\t\t\t """ 3 => """ E Grant \n \t\t\t\t\t\t\t\t """ 4 => """ S Julius \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.hyp.27.4.854" "Revista" => array:7 [ "tituloSerie" => "Hypertension" "fecha" => "1996" "volumen" => "27" "numero" => "4" "paginaInicial" => "854" "paginaFinal" => "858" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8613260" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vasoconstriction with norepinephrine causes less forearm insulin resistance than a reflex sympathetic vasoconstriction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ KA Jamerson \n \t\t\t\t\t\t\t\t """ 1 => """ SD Smith \n \t\t\t\t\t\t\t\t """ 2 => """ JV Amerena \n \t\t\t\t\t\t\t\t """ 3 => """ E Grant \n \t\t\t\t\t\t\t\t """ 4 => """ S Julius \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.hyp.23.6.1006" "Revista" => array:7 [ "tituloSerie" => "Hypertension" "fecha" => "1994" "volumen" => "23" "numero" => "6 Pt 2" "paginaInicial" => "1006" "paginaFinal" => "1011" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8206583" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Application of prazosin is associated with an increase of insulin sensitivity in obese patients with hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ T Pollare \n \t\t\t\t\t\t\t\t """ 1 => """ H Lithell \n \t\t\t\t\t\t\t\t """ 2 => """ I Selinus \n \t\t\t\t\t\t\t\t """ 3 => """ C Berne \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/BF00271585" "Revista" => array:7 [ "tituloSerie" => "Diabetologia" "fecha" => "1988" "volumen" => "31" "numero" => "7" "paginaInicial" => "415" "paginaFinal" => "420" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3065104" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased sympathetic and decreased parasympathetic activity rather than changes in hypothalamic-pituitary-adrenal axis activity is associated with metabolic abnormalities" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ CM Licht \n \t\t\t\t\t\t\t\t """ 1 => """ SA Vreeburg \n \t\t\t\t\t\t\t\t """ 2 => """ AK van Reedt Dortland \n \t\t\t\t\t\t\t\t """ 3 => """ EJ Giltay \n \t\t\t\t\t\t\t\t """ 4 => """ WJ Hoogendijk \n \t\t\t\t\t\t\t\t """ 5 => """ RH DeRijk \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jc.2009-2801" "Revista" => array:7 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "2010" "volumen" => "95" "numero" => "5" "paginaInicial" => "2458" "paginaFinal" => "2466" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20237163" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ C Weyer \n \t\t\t\t\t\t\t\t """ 1 => """ T Funahashi \n \t\t\t\t\t\t\t\t """ 2 => """ S Tanaka \n \t\t\t\t\t\t\t\t """ 3 => """ K Hotta \n \t\t\t\t\t\t\t\t """ 4 => """ Y Matsuzawa \n \t\t\t\t\t\t\t\t """ 5 => """ RE Pratley \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jcem.86.5.7463" "Revista" => array:7 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "2001" "volumen" => "86" "numero" => "5" "paginaInicial" => "1930" "paginaFinal" => "1935" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11344187" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between the sympathetic firing pattern and anxiety level in patients with the metabolic syndrome and elevated blood pressure" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ E Lambert \n \t\t\t\t\t\t\t\t """ 1 => """ T Dawood \n \t\t\t\t\t\t\t\t """ 2 => """ N Straznicky \n \t\t\t\t\t\t\t\t """ 3 => """ C Sari \n \t\t\t\t\t\t\t\t """ 4 => """ M Schlaich \n \t\t\t\t\t\t\t\t """ 5 => """ M Esler \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/HJH.0b013e3283350ea4" "Revista" => array:7 [ "tituloSerie" => "J Hypertens" "fecha" => "2010" "volumen" => "28" "numero" => "3" "paginaInicial" => "543" "paginaFinal" => "550" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20139772" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Changes in plasma lipids with psychosocial stress are related to hypertension status and the norepinephrine stress response" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ PH Wirtz \n \t\t\t\t\t\t\t\t """ 1 => """ U Ehlert \n \t\t\t\t\t\t\t\t """ 2 => """ C Bartschi \n \t\t\t\t\t\t\t\t """ 3 => """ LS Redwine \n \t\t\t\t\t\t\t\t """ 4 => """ R von Kanel \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.metabol.2008.08.003" "Revista" => array:7 [ "tituloSerie" => "Metabolism" "fecha" => "2009" "volumen" => "58" "numero" => "1" "paginaInicial" => "30" "paginaFinal" => "37" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19059528" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ AV Chobanian \n \t\t\t\t\t\t\t\t """ 1 => """ GL Bakris \n \t\t\t\t\t\t\t\t """ 2 => """ HR Black \n \t\t\t\t\t\t\t\t """ 3 => """ WC Cushman \n \t\t\t\t\t\t\t\t """ 4 => """ LA Green \n \t\t\t\t\t\t\t\t """ 5 => """ JL Izzo Jr \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.HYP.0000107251.49515.c2" "Revista" => array:7 [ "tituloSerie" => "Hypertension" "fecha" => "2003" "volumen" => "42" "numero" => "6" "paginaInicial" => "1206" "paginaFinal" => "1252" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14656957" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of continuous positive airway pressure on early signs of atherosclerosis in obstructive sleep apnea" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ LF Drager \n \t\t\t\t\t\t\t\t """ 1 => """ LA Bortolotto \n \t\t\t\t\t\t\t\t """ 2 => """ AC Figueiredo \n \t\t\t\t\t\t\t\t """ 3 => """ EM Krieger \n \t\t\t\t\t\t\t\t """ 4 => """ GF Lorenzi \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200703-500OC" "Revista" => array:7 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2007" "volumen" => "176" "numero" => "7" "paginaInicial" => "706" "paginaFinal" => "712" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17556718" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Consequences of comorbid sleep apnea in the metabolic syndrome-implications for cardiovascular risk" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ IC Trombetta \n \t\t\t\t\t\t\t\t """ 1 => """ VK Somers \n \t\t\t\t\t\t\t\t """ 2 => """ C Maki-Nunes \n \t\t\t\t\t\t\t\t """ 3 => """ LF Drager \n \t\t\t\t\t\t\t\t """ 4 => """ E Toschi-Dias \n \t\t\t\t\t\t\t\t """ 5 => """ MJ Alves \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/sleep/33.9.1193" "Revista" => array:7 [ "tituloSerie" => "Sleep" "fecha" => "2010" "volumen" => "33" "numero" => "9" "paginaInicial" => "1193" "paginaFinal" => "1199" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20857866" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The impact of obstructive sleep apnea on metabolic and inflammatory markers in consecutive patients with metabolic syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ LF Drager \n \t\t\t\t\t\t\t\t """ 1 => """ HF Lopes \n \t\t\t\t\t\t\t\t """ 2 => """ C Maki-Nunes \n \t\t\t\t\t\t\t\t """ 3 => """ IC Trombetta \n \t\t\t\t\t\t\t\t """ 4 => """ E Toschi-Dias \n \t\t\t\t\t\t\t\t """ 5 => """ MJ Alves \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "PLoS One" "fecha" => "2010" "volumen" => "5" "numero" => "8" ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obstructive sleep apnea, hypertension, and their interaction on arterial stiffness and heart remodeling" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ LF Drager \n \t\t\t\t\t\t\t\t """ 1 => """ LA Bortolotto \n \t\t\t\t\t\t\t\t """ 2 => """ AC Figueiredo \n \t\t\t\t\t\t\t\t """ 3 => """ BC Silva \n \t\t\t\t\t\t\t\t """ 4 => """ EM Krieger \n \t\t\t\t\t\t\t\t """ 5 => """ G Lorenzi-Filho \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.06-2703" "Revista" => array:7 [ "tituloSerie" => "Chest" "fecha" => "2007" "volumen" => "131" "numero" => "5" "paginaInicial" => "1379" "paginaFinal" => "1386" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17494787" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antihypertensive effect of alpha- and beta-adrenergic blockade in obese and lean hypertensive subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ MR Wofford \n \t\t\t\t\t\t\t\t """ 1 => """ DC Anderson Jr \n \t\t\t\t\t\t\t\t """ 2 => """ CA Brown \n \t\t\t\t\t\t\t\t """ 3 => """ DW Jones \n \t\t\t\t\t\t\t\t """ 4 => """ ME Miller \n \t\t\t\t\t\t\t\t """ 5 => """ JE Hall \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0895-7061(01)01293-6" "Revista" => array:7 [ "tituloSerie" => "Am J Hypertens" "fecha" => "2001" "volumen" => "14" "numero" => "7 Pt 1" "paginaInicial" => "694" "paginaFinal" => "698" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11465655" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of renal sympathetic denervation on blood pressure, sleep apnea course, and glycemic control in patients with resistant hypertension and sleep apnea" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ A Witkowski \n \t\t\t\t\t\t\t\t """ 1 => """ A Prejbisz \n \t\t\t\t\t\t\t\t """ 2 => """ E Florczak \n \t\t\t\t\t\t\t\t """ 3 => """ J KĄdziela \n \t\t\t\t\t\t\t\t """ 4 => """ P Śliwiński \n \t\t\t\t\t\t\t\t """ 5 => """ P Bielen \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/HYPERTENSIONAHA.111.173799" "Revista" => array:7 [ "tituloSerie" => "Hypertension" "fecha" => "2011" "volumen" => "58" "numero" => "4" "paginaInicial" => "559" "paginaFinal" => "565" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21844482" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The incremental role of obstructive sleep apnoea on markers of atherosclerosis in patients with metabolic syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ LF Drager \n \t\t\t\t\t\t\t\t """ 1 => """ LA Bortolotto \n \t\t\t\t\t\t\t\t """ 2 => """ C Maki-Nunes \n \t\t\t\t\t\t\t\t """ 3 => """ IC Trombetta \n \t\t\t\t\t\t\t\t """ 4 => """ MJ Alves \n \t\t\t\t\t\t\t\t """ 5 => """ RF Fraga \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.atherosclerosis.2009.08.016" "Revista" => array:7 [ "tituloSerie" => "Atherosclerosis" "fecha" => "2010" "volumen" => "208" "numero" => "2" "paginaInicial" => "490" "paginaFinal" => "495" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19762024" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antihypertensive effect of alpha- and beta-adrenergic blockade in obese and lean hypertensive subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ MR Wofford \n \t\t\t\t\t\t\t\t """ 1 => """ DC Anderson Jr \n \t\t\t\t\t\t\t\t """ 2 => """ CA Brown \n \t\t\t\t\t\t\t\t """ 3 => """ DW Jones \n \t\t\t\t\t\t\t\t """ 4 => """ ME Miller \n \t\t\t\t\t\t\t\t """ 5 => """ JE Hall \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0895-7061(01)01293-6" "Revista" => array:7 [ "tituloSerie" => "Am J Hypertens" "fecha" => "2001" "volumen" => "14" "numero" => "7 Pt 1" "paginaInicial" => "694" "paginaFinal" => "698" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11465655" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of renal sympathetic denervation on blood pressure, sleep apnea course, and glycemic control in patients with resistant hypertension and sleep apnea" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ A Witkowski \n \t\t\t\t\t\t\t\t """ 1 => """ A Prejbisz \n \t\t\t\t\t\t\t\t """ 2 => """ E Florczak \n \t\t\t\t\t\t\t\t """ 3 => """ J Kadziela \n \t\t\t\t\t\t\t\t """ 4 => """ P Sliwinski \n \t\t\t\t\t\t\t\t """ 5 => """ P Bielen \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/HYPERTENSIONAHA.111.173799" "Revista" => array:7 [ "tituloSerie" => "Hypertension" "fecha" => "2011" "volumen" => "58" "numero" => "4" "paginaInicial" => "559" "paginaFinal" => "565" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21844482" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/18075932/0000006800000012/v1_202212011241/S1807593222020361/v1_202212011241/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/18075932/0000006800000012/v1_202212011241/S1807593222020361/v1_202212011241/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222020361?idApp=UINPBA00004N"]

Statistics

CLINICAL SCIENCE

Juliana S. GilI, Luciano F. DragerI, Grazia M. Guerra-RiccioI, Cristiano MostardaI, Maria C. IrigoyenI, Valeria Costa-HongI, Luiz A. BortolottoI, Brent M. EganII, Heno F. LopesI,,III,

Corresponding author

hipheno@incor.usp.br

Tel.: 55 11 2661-5084

I Faculdade de Medicina da Universidade de São Paulo, Heart Institute (InCor), São Paulo/SP, Brazil.

II Medical University of South Carolina, Charleston/SC, USA.

III Universidade Nove de Julho – UNINOVE, São Paulo/SP, Brazil.

Read

914

Times
was read the article

265

Total PDF

649

Total HTML

Share statistics

 array:24 [
  "pii" => "S1807593222020361"
  "issn" => "18075932"
  "doi" => "10.6061/clinics/2013(12)04"
  "estado" => "S300"
  "fechaPublicacion" => "2013-01-01"
  "aid" => "2036"
  "copyright" => "CLINICS"
  "copyrightAnyo" => "2013"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
  "subdocumento" => "fla"
  "cita" => "Clinics. 2013;68:1495-501"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1807593222020373"
    "issn" => "18075932"
    "doi" => "10.6061/clinics/2013(12)05"
    "estado" => "S300"
    "fechaPublicacion" => "2013-01-01"
    "aid" => "2037"
    "copyright" => "CLINICS"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
    "subdocumento" => "fla"
    "cita" => "Clinics. 2013;68:1502-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">CLINICAL SCIENCE</span>"
      "titulo" => "The involvement of multiple thrombogenic and atherogenic markers in premature coronary artery disease"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "1502"
          "paginaFinal" => "1508"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig2"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1046
              "Ancho" => 793
              "Tamanyo" => 76689
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Receiver operating characteristic &#40;ROC&#41; curves&#46; Model1 included the following variables&#58; gender&#44; hypertension&#44; smoking&#44; diabetes&#44; family history of CAD&#44; dyslipidemia&#44; and body mass index&#46; Model1 <span class="elsevierStyleItalic">vs</span>&#46; Model1&#43;Lp&#40;a&#41; &#40;<span class="elsevierStyleItalic">p</span>&#8202;&#61;&#8202;0&#46;047&#41;&#59; Model1 <span class="elsevierStyleItalic">vs</span>&#46; Model1&#43;Lp&#40;a&#41;&#43;LTA &#40;<span class="elsevierStyleItalic">p</span>&#8202;&#61;&#8202;0&#46;024&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Antonio P&#46; Mansur, Julio Y&#46; Takada, C&#233;lia M&#46;C&#46; Strunz, Solange D&#46; Avakian, Luiz Antonio M&#46; C&#233;sar, Jos&#233; A&#46;F&#46; Ramires"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Antonio P&#46;"
              "apellidos" => "Mansur"
            ]
            1 => array:2 [
              "nombre" => "Julio Y&#46;"
              "apellidos" => "Takada"
            ]
            2 => array:2 [
              "nombre" => "C&#233;lia M&#46;C&#46;"
              "apellidos" => "Strunz"
            ]
            3 => array:2 [
              "nombre" => "Solange D&#46;"
              "apellidos" => "Avakian"
            ]
            4 => array:2 [
              "nombre" => "Luiz Antonio M&#46;"
              "apellidos" => "C&#233;sar"
            ]
            5 => array:2 [
              "nombre" => "Jos&#233; A&#46;F&#46;"
              "apellidos" => "Ramires"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222020373?idApp=UINPBA00004N"
    "url" => "/18075932/0000006800000012/v1_202212011241/S1807593222020373/v1_202212011241/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S180759322202035X"
    "issn" => "18075932"
    "doi" => "10.6061/clinics/2013(12)03"
    "estado" => "S300"
    "fechaPublicacion" => "2013-01-01"
    "aid" => "2035"
    "copyright" => "CLINICS"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
    "subdocumento" => "fla"
    "cita" => "Clinics. 2013;68:1488-94"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">CLINICAL SCIENCE</span>"
      "titulo" => "pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "1488"
          "paginaFinal" => "1494"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig2"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 411
              "Ancho" => 770
              "Tamanyo" => 33580
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">The proportions of cells &#40;&#37;&#41; in the nasal lavage fluid of the traffic-controllers and office-workers&#46; The data were analyzed by the Kruskal-Wallis test&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Thamires Marques de Lima, Cristiane Mayumi Kazama, Andreas Rembert Koczulla, Pieter S&#46; Hiemstra, Mariangela Macchione, Ana Luisa Godoy Fernandes, Ubiratan de Paula Santos, Maria Lucia Bueno-Garcia, Dirce Maria Zanetta, Carmen Diva Saldiva de Andr&#233;, Paulo Hilario Nascimento Saldiva, Naomi Kondo Nakagawa"
          "autores" => array:12 [
            0 => array:2 [
              "nombre" => "Thamires Marques"
              "apellidos" => "de Lima"
            ]
            1 => array:2 [
              "nombre" => "Cristiane Mayumi"
              "apellidos" => "Kazama"
            ]
            2 => array:2 [
              "nombre" => "Andreas Rembert"
              "apellidos" => "Koczulla"
            ]
            3 => array:2 [
              "nombre" => "Pieter S&#46;"
              "apellidos" => "Hiemstra"
            ]
            4 => array:2 [
              "nombre" => "Mariangela"
              "apellidos" => "Macchione"
            ]
            5 => array:2 [
              "nombre" => "Ana Luisa Godoy"
              "apellidos" => "Fernandes"
            ]
            6 => array:2 [
              "nombre" => "Ubiratan"
              "apellidos" => "de Paula Santos"
            ]
            7 => array:2 [
              "nombre" => "Maria Lucia"
              "apellidos" => "Bueno-Garcia"
            ]
            8 => array:2 [
              "nombre" => "Dirce Maria"
              "apellidos" => "Zanetta"
            ]
            9 => array:2 [
              "nombre" => "Carmen Diva Saldiva"
              "apellidos" => "de Andr&#233;"
            ]
            10 => array:2 [
              "nombre" => "Paulo Hilario Nascimento"
              "apellidos" => "Saldiva"
            ]
            11 => array:2 [
              "nombre" => "Naomi Kondo"
              "apellidos" => "Nakagawa"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S180759322202035X?idApp=UINPBA00004N"
    "url" => "/18075932/0000006800000012/v1_202212011241/S180759322202035X/v1_202212011241/en/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">CLINICAL SCIENCE</span>"
    "titulo" => "The impact of metabolic syndrome on metabolic&#44; pro-inflammatory and prothrombotic markers according to the presence of high blood pressure criterion"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "1495"
        "paginaFinal" => "1501"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Juliana S&#46; Gil, Luciano F&#46; Drager, Grazia M&#46; Guerra-Riccio, Cristiano Mostarda, Maria C&#46; Irigoyen, Valeria Costa-Hong, Luiz A&#46; Bortolotto, Brent M&#46; Egan, Heno F&#46; Lopes"
        "autores" => array:9 [
          0 => array:3 [
            "nombre" => "Juliana S&#46;"
            "apellidos" => "Gil"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Luciano F&#46;"
            "apellidos" => "Drager"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Grazia M&#46;"
            "apellidos" => "Guerra-Riccio"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Cristiano"
            "apellidos" => "Mostarda"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Maria C&#46;"
            "apellidos" => "Irigoyen"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Valeria"
            "apellidos" => "Costa-Hong"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Luiz A&#46;"
            "apellidos" => "Bortolotto"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Brent M&#46;"
            "apellidos" => "Egan"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">II</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          8 => array:4 [
            "nombre" => "Heno F&#46;"
            "apellidos" => "Lopes"
            "email" => array:1 [
              0 => "hipheno@incor.usp.br"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I&#44;</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">III</span>"
                "identificador" => "aff3"
              ]
              2 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor1"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Faculdade de Medicina da Universidade de S&#227;o Paulo&#44; Heart Institute &#40;InCor&#41;&#44; S&#227;o Paulo&#47;SP&#44; Brazil&#46;"
            "etiqueta" => "I"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Medical University of South Carolina&#44; Charleston&#47;SC&#44; USA&#46;"
            "etiqueta" => "II"
            "identificador" => "aff2"
          ]
          2 => array:3 [
            "entidad" => "Universidade Nove de Julho &#8211; UNINOVE&#44; S&#227;o Paulo&#47;SP&#44; Brazil&#46;"
            "etiqueta" => "III"
            "identificador" => "aff3"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#42;"
            "correspondencia" => "Tel&#46;&#58; 55 11 2661-5084"
          ]
        ]
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig1"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 564
            "Ancho" => 795
            "Tamanyo" => 39832
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Flow diagram used to screen patients&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle60">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">In 1988&#44; the cardiovascular risk factor cluster&#44; which includes obesity&#44; increased blood pressure&#44; high triglycerides and glucose and low HDL &#40;high-density lipoprotein&#41;-cholesterol&#44; was given the name &#8220;metabolic syndrome&#8221; &#40;MetS&#41; &#40;<a class="elsevierStyleCrossRef" href="#bib1">1</a>&#41;&#46; Since then&#44; the scientific community has tried to better define whether MetS predicts cardiovascular morbidity and mortality better than the sum of the individual components and whether one component is pivotal over the others&#46; Most evidence points to visceral obesity and insulin resistance as central features of MetS&#46; Little attention has been given to exploring other components of MetS&#44; such as blood pressure and the potential factors that can influence not only blood pressure but also the metabolic dysregulation observed in MetS&#46;</p><p id="para20" class="elsevierStylePara elsevierViewall">Obesity-related sympathetic activation is an attractive explanation for several components of MetS&#46; In particular&#44; in 1994&#44; the aggregation of cardiovascular risk factors and signs of a hyper sympathetic state was demonstrated in the Tecumseh population &#40;<a class="elsevierStyleCrossRef" href="#bib2">2</a>&#41;&#46; Indeed&#44; increased sympathetic activity &#40;faster heart rate&#44; higher cardiac output and plasma noradrenaline&#41; correlated with higher levels of glucose&#44; insulin&#44; cholesterol&#44; triglycerides&#44; body weight and hematocrit and lower levels of HDL-cholesterol&#46; In the Framingham Heart Study &#40;<a class="elsevierStyleCrossRef" href="#bib3">3</a>&#41;&#44; more than 50&#37; of hypertensive patients had 2 or more metabolic abnormalities&#46; Only 19&#37; of males and 17&#37; of females had isolated hypertension&#46; In view of this finding&#44; the name hypertensive syndrome had been used in the past &#40;<a class="elsevierStyleCrossRef" href="#bib4">4</a>&#41;&#46; However&#44; it is not clear whether the increase in blood pressure is associated with exacerbations of the metabolic&#44; proinflammatory&#44; prothrombotic&#44; vascular and autonomic dysfunctions in patients with MetS&#46;</p><p id="para30" class="elsevierStylePara elsevierViewall">Evidence suggests that autonomic dysregulation also contributes to elevated blood pressure and metabolic abnormalities&#46; Moreover&#44; &#945;<span class="elsevierStyleInf">1</span>-adrenoceptor antagonists lower blood pressure&#44; improve insulin sensitivity and ameliorate dyslipidemia &#40;<a class="elsevierStyleCrossRef" href="#bib5">5</a>&#41;&#46; However&#44; it is unclear whether autonomic dysregulation in metabolic syndrome is associated not only with hemodynamic impairment but also with metabolic&#44; inflammatory and other abnormalities associated with the syndrome&#46; We hypothesized that high blood pressure&#44; which may reflect increased sympathetic activity&#44; is independently associated with metabolic dysregulation and inflammation in patients with MetS&#46;</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">METHODS</span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">Study population</span><p id="para40" class="elsevierStylePara elsevierViewall">This research was performed at the Heart Institute &#40;InCor&#41; at the University of S&#227;o Paulo Medical School&#46; Over a 1-year period&#44; we initially evaluated 135 consecutive overweight or obese patients from the S&#227;o Paulo metropolitan area&#46; From this group&#44; we selected 75 patients with MetS&#44; diagnosed according to ATP III &#40;Third Report of the Expert Panel on Detection&#44; Evaluation and Treatment of High Blood Cholesterol in Adults criteria&#44; and with at least three of the following criteria&#58; high blood pressure - arterial blood pressure &#8805;130 and&#47;or &#8805;85 mmHg for systolic and diastolic blood pressure&#44; respectively&#59; high glucose - fasting glucose &#8805;100 mg&#47;dL&#59; increased waist circumference - &#8805;102 cm in men and &#8805;88 in women&#59; increased triglycerides - &#8805;150 mg&#47;dL&#59; decreased HDL - &#60;40 mg&#47;dL in men and &#60;50 mg&#47;mg&#47;dL in women&#41; &#40;<a class="elsevierStyleCrossRef" href="#bib6">6</a>&#41;&#46; We excluded patients with morbid obesity &#40;body mass index &#8805;40 kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#44; severe hypertension &#40;BP &#62;180&#47;110 mmHg&#41;&#44; under regular physical activity&#44; secondary forms of hypertension&#44; diabetes&#44; smokers&#44; patients with any chronic disease and regularly using medications &#40;including antihypertensives&#44; see <a class="elsevierStyleCrossRef" href="#fig1">Figure&#160;1</a>&#41;&#46; The patients were divided into 2 groups according to blood pressure status &#40;patients with MetS without high blood pressure&#44; i&#46;e&#46;&#44; &#60;130&#47;&#60;85 mmHg&#58; MetS-BP&#41; and &#40;patients with MetS with high blood pressure&#44; i&#46;e&#46;&#44; &#8805;130 systolic and&#47;or &#8805;85 mmHg diastolic&#58; MetS&#43;BP&#41;&#46;</p><elsevierMultimedia ident="fig1"></elsevierMultimedia></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">Clinical evaluation</span><p id="para50" class="elsevierStylePara elsevierViewall">Patients who fulfilled the criteria for the study underwent a medical history evaluation&#46; Blood pressure was measured in triplicate after 5 minutes of seated rest using a calibrated sphygmomanometer by the same investigator &#40;J&#46;S&#46;G&#41;&#46; The average from 3 blood pressure values was used to define the presence or absence of the ATP III&#44; the criterion used to define elevated blood pressure &#40;&#8805;130 or &#8805;85 mmHg for systolic and diastolic blood pressure levels&#44; respectively&#41;&#46; Fasting blood samples were drawn for biochemical tests and cytokine levels&#46; Serum and plasma were obtained and then stored at -80&#176;C&#46; During the second visit&#44; anthropometric measurements &#40;body mass index &#8211; BMI&#59; waist and hip circumferences&#59; and bicipital&#44; tricipital&#44; subscapular and suprailiac skinfolds&#41; and fat mass&#44; lean mass&#44; basal metabolism and total body water were measured using bioimpedance-measuring equipment &#40;BIA 450&#44; Bio dynamics&#44; Seattle&#44; USA&#41; &#40;<a class="elsevierStyleCrossRef" href="#bib7">7</a>&#41;&#46;</p></span><span id="cesec50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle100">Biochemistry measurements</span><p id="para60" class="elsevierStylePara elsevierViewall">Total cholesterol&#44; LDL-cholesterol&#44; HDL-cholesterol&#44; triglycerides&#44; uric acid&#44; glucose and creatinine levels were measured using commercial kits&#46;</p></span><span id="cesec60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle110">Insulin resistance</span><p id="para70" class="elsevierStylePara elsevierViewall">Insulin resistance was measured using the following 2 methods&#58; the traditional Homeostasis Model Assessment Insulin Resistance method &#40;HOMA-IR&#41; and the Retinol-Binding Protein 4 method &#40;RBP4&#41;&#46; The HOMA-IR index was calculated as &#91;fasting serum glucose &#40;mmol&#47;L&#41; x fasting serum insulin &#40;UI&#47;mL&#41;&#93;&#47;22&#46;5&#46;</p></span><span id="cesec70" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle120">Cytokines</span><p id="para80" class="elsevierStylePara elsevierViewall">Cytokines&#44; including total adiponectin&#44; resistin&#44; leptin&#44; insulin&#44; interleukin 6 &#40;IL-6&#41;&#44; tumoral necrosis factor alpha &#40;TNF-&#945;&#41;&#44; plasminogen activator inhibitor 1 &#40;PAI-1&#41; and monocyte chemoattractant protein 1 &#40;MCP-1&#41;&#44; were measured using a multiplex sandwich enzyme-linked immunosorbent assay &#40;ELISA&#44; Millipore&#44; MA&#44; USA&#41; &#40;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#41;&#46;</p></span><span id="cesec80" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle130">Power spectral analysis</span><p id="para90" class="elsevierStylePara elsevierViewall">The data for spectral analysis were derived from a finger pulse contour recorded by beat-to-beat blood pressure measurements &#40;Finometer&#174;&#44; FMS&#44; Finapres Medical System BV&#44; Holland&#41; and from the electrocardiogram &#40;ECG&#41; for 10 minutes to characterize the RR interval series&#46; Power spectral density was obtained by the fast Fourier transformation&#44; using Welch&#39;s method with a Hanning window of 512 points and 50&#37; overlap as previously described &#40;<a class="elsevierStyleCrossRef" href="#bib9">9</a>&#41;&#46; The entire time&#44; series were previously re-sampled at 5&#46;0 Hz to be equally spaced in time by a special signal editor developed for Matlab &#40;MATLAB 6&#46;0&#59; Mathworks&#44; Natick&#44; Massachusetts&#44; USA&#41;&#46; Interpolated time series were decimated to be equally time-spaced&#46; Two main components were considered for the RR interval variability&#58; low frequency &#40;LF&#59; 0&#46;04 to 0&#46;15 Hz&#41; and high frequency &#40;HF&#59; 0&#46;15 to 0&#46;4 Hz&#41;&#46; The power density of each spectral component from the RR interval was calculated in absolute values and normalized units&#46; The normalized units were obtained by calculating the percentages of LF variability &#40;LFms<span class="elsevierStyleSup">2</span>&#41; and HF variability &#40;HFms<span class="elsevierStyleSup">2</span>&#41; with respect to the total power after subtracting the power of very low frequency components &#40;VLF&#59; frequencies of &#60;0&#46;04 Hz&#41;&#46; The LF&#47;HF ratio was also calculated to evaluate the sympathovagal balance&#46; In addition&#44; we also evaluated the power spectral analysis of systolic BP&#46; Systolic BP spectral powers were quantified in the LF component &#40;0&#46;04&#8211;0&#46;15 Hz&#41; and were reported in absolute units&#46; LF of systolic BP has been associated as a reliable marker of sympathetic activity &#40;<a class="elsevierStyleCrossRef" href="#bib10">10</a>&#41;&#46;</p></span><span id="cesec90" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle140">Baroreflex sensitivity</span><p id="para100" class="elsevierStylePara elsevierViewall">Beat-to-beat values of systolic BP and RR interval were used to estimate the cardiac baroreflex sensitivity &#40;BRS&#41; by spectral analysis&#44; using the alpha index for the low-frequency band &#40;0&#46;04 to 0&#46;15 Hz&#41;&#46; The coherence between the RR interval and the systolic BP signal variability was assessed by cross-spectral analysis&#46; The alpha index was calculated only when the magnitude of the squared coherence between the RR and systolic BP signals exceeded 0&#46;5 &#40;range 0&#8211;1&#41; in the LF band&#46; After coherence calculation&#44; the alpha index was obtained from the square root of the ratio between RR and systolic BP variability in the 2 major LF bands &#40;<a class="elsevierStyleCrossRefs" href="#bib10">10-13</a>&#41;&#46;</p></span><span id="cesec100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle150">Anxiety and depression evaluation</span><p id="para110" class="elsevierStylePara elsevierViewall">We performed the Hamilton Scale to assess anxiety &#40;<a class="elsevierStyleCrossRefs" href="#bib14">14-15</a>&#41; and the Beck questionnaire to assess depression &#40;<a class="elsevierStyleCrossRef" href="#bib16">16</a>&#41;&#46;</p></span><span id="cesec110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle160">Statistical analysis</span><p id="para120" class="elsevierStylePara elsevierViewall">The SPSS software &#40;SPSS 10&#46;0&#44; Chicago&#44; IL&#41; was used for statistical calculations&#46; Data were expressed as the means&#177;standard deviations&#44; medians or percentages&#44; as indicated&#46; The Kolmogorov-Smirnov test was used to assess the normality of distribution of each variable studied&#46; Categorical variables &#40;sex&#44; race and percentage of MetS components&#41; were compared using Fisher&#39;s test&#46; Numerical variables were compared using the unpaired Student&#39;s t test&#46; Logistic regression analysis &#40;forward model&#41; was used to identify the metabolic&#44; pro-inflammatory and prothrombotic markers that were independently associated with the MetS&#43;BP&#46; The model was controlled for age and BMI&#46; ANOVA was used to select variables for the logistic regression analysis&#46; All variables with a <span class="elsevierStyleItalic">p</span>&#60;0&#46;1 in the univariate analysis were selected for the final model&#46; <span class="elsevierStyleItalic">P</span>&#60;0&#46;05 was considered to be statistically significant&#46;</p></span><span id="cesec120" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle170">Ethics statement</span><p id="para130" class="elsevierStylePara elsevierViewall">The local ethics committee &#40;Institutional Review Board &#8211; Heart Institute&#41; approved the protocol&#44; which was in accordance with the ethical standards and with the Helsinki Declaration of 1975&#44; and all participants gave written informed consent&#46;</p></span></span><span id="cesec130" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle180">RESULTS</span><p id="para140" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig1">Figure&#160;1</a> depicts derivation of the study sample of 75 subjects from the initial sample of 135 patients with MetS&#46; The percentage of each MetS criterion is reported in the supplemental file&#46;</p><p id="para150" class="elsevierStylePara elsevierViewall">Baseline descriptive data on the MetS patients without &#40;N&#8202;&#61;&#8202;45&#41; and with &#40;N&#8202;&#61;&#8202;30&#41; high blood pressure are provided in <a class="elsevierStyleCrossRef" href="#t1-cln_68p1495">Table&#160;1</a>&#46; We observed a significant trend for increasing age in the MetS&#43;BP group&#46; There was no significant difference in gender&#44; &#37; of Caucasians and anthropometric data&#44; including body mass index&#44; waist circumference&#44; hip circumference&#44; waist-to-hip ratio&#44; fat percentage as calculated by skinfold&#44; fat mass&#44; lean mass&#44; metabolic tax and total body water estimated by bioelectrical impedance analysis &#40;BIA&#41; &#40;<a class="elsevierStyleCrossRef" href="#t1-cln_68p1495">Table&#160;1</a>&#41;&#46; As expected&#44; there were significant differences in the systolic and diastolic blood pressure measurements between groups&#46; Pulse intervals during spectral analysis were significantly lower &#40;heart rate faster&#41; in the MetS&#43;BP compared to the MetS-BP group &#40;<a class="elsevierStyleCrossRef" href="#t2-cln_68p1495">Table&#160;2</a>&#41;&#46; The LF components for heart rate and blood pressure and the LF&#47;HF ratio were significantly higher in the MetS&#43;BP group than in the MetS-BP group&#46; Baroreflex sensitivity&#44; as evaluated by the alpha index&#44; was impaired in the MetS&#43;BP group compared with the MetS-BP group&#46; No differences were detected between groups with regards to anxiety and depression &#40;supplemental file&#41;&#46;</p><elsevierMultimedia ident="t1-cln_68p1495"></elsevierMultimedia><elsevierMultimedia ident="t2-cln_68p1495"></elsevierMultimedia><p id="para160" class="elsevierStylePara elsevierViewall">Biochemistry data &#40;glucose&#44; total cholesterol&#44; HDL-cholesterol&#44; LDL-cholesterol&#44; triglycerides&#44; uric acid and creatinine&#41;&#44; along with insulin and the HOMA-IR index&#44; were significantly higher in the MetS&#43;BP group than in the MetS-BP group &#40;<a class="elsevierStyleCrossRef" href="#t3-cln_68p1495">Table&#160;3</a>&#41;&#46;</p><elsevierMultimedia ident="t3-cln_68p1495"></elsevierMultimedia><p id="para170" class="elsevierStylePara elsevierViewall">RBP4 was significantly higher in the MetS&#43;BP group than the MetS-BP group &#40;<a class="elsevierStyleCrossRef" href="#fig2">Figure&#160;2A</a>&#41;&#46; Leptin&#44; resistin and TNF-&#945; levels did not differ between the MetS&#43;BP group &#40;49&#46;4&#177;41&#46;5 pg&#47;mL&#44; 12&#46;6&#177;4&#46;6 pg&#47;mL and 4&#46;8&#177;1&#46;7 ng&#47;mL&#44; respectively&#41; and the MetS-BP group &#40;41&#46;4&#177;20&#46;0 pg&#47;mL&#44; 12&#46;9&#177;4&#46;9 pg&#47;mL and 4&#46;4&#177;1&#46;4 ng&#47;mL&#44; respectively&#41;&#46; IL-6&#44; PAI-1 and MCP-1&#44; a marker for inflammatory activity&#44; were significantly higher in the MetS&#43;BP group &#40;<a class="elsevierStyleCrossRef" href="#fig2">Figures&#160;2B-2D</a>&#41;&#46; Adiponectin was lower in the MetS&#43;BP group compared to the MetS-BP group &#40;<a class="elsevierStyleCrossRef" href="#fig2">Figure&#160;2E</a>&#41;&#46; The differences in RBP4&#44; PAI-1&#44; IL-6&#44; MCP-1 and adiponectin levels between groups remained significant after adjusting for age and sex&#46;</p><elsevierMultimedia ident="fig2"></elsevierMultimedia><p id="para180" class="elsevierStylePara elsevierViewall">Logistic regression analysis indicated that HDL&#44; RBP-4 and PAI-1 levels were independently associated with MetS&#43;BP&#46; There was a strong trend for an independent association between MetS&#43;BP and glucose levels &#40;<a class="elsevierStyleCrossRef" href="#t4-cln_68p1495">Table&#160;4</a>&#41;&#46;</p><elsevierMultimedia ident="t4-cln_68p1495"></elsevierMultimedia></span><span id="cesec140" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle190">DISCUSSION</span><p id="para190" class="elsevierStylePara elsevierViewall">Previous studies have shown that patients with MetS have multiple abnormalities that contribute to increased cardiovascular risk&#44; including metabolic&#44; proinflammatory&#44; prothrombotic and autonomic variables &#40;<a class="elsevierStyleCrossRefs" href="#bib17">17-19</a>&#41;&#46; We hypothesized that MetS patients with elevated blood pressure may have greater abnormalities in these same variables&#46; By stratifying patients with similar obesity levels according to the presence or absence of high blood pressure&#44; we found that those with high blood pressure &#40;MetS&#43;BP&#41; had higher surrogate markers of sympathetic activity derived from spectral analysis and greater impairment in several components of MetS&#44; including higher glucose and triglycerides and lower HDL-cholesterol&#46; The MetS group with high blood pressure also had higher values for other risk factors&#44; including total cholesterol&#44; LDL-cholesterol&#44; uric acid and insulin&#44; along with HOMA index and RBP4&#44; which are associated with insulin resistance &#40;<a class="elsevierStyleCrossRef" href="#bib17">17</a>&#44;<a class="elsevierStyleCrossRef" href="#bib20">20</a>&#44;<a class="elsevierStyleCrossRef" href="#bib21">21</a>&#41;&#46; In addition&#44; several markers of inflammatory and prothrombotic activity&#44; including IL-6&#44; PAI-1 and MCP-1&#44; were higher&#44; while adiponectin levels were lower in patients with MetS and high blood pressure&#46; Finally&#44; we found that HDL-cholesterol&#44; RBP4 and PAI-1 were independently associated with MetS&#43;BP&#46; Taken together&#44; our results suggest a significant heterogeneity of the MetS in promoting metabolic&#44; pro-inflammatory&#44; prothrombotic and autonomic impairments&#46;</p><p id="para200" class="elsevierStylePara elsevierViewall">MetS was defined based on the observation that a number of interrelated characteristics and diseases tended to cluster in the same individual and contributed to increased cardiovascular risk&#46; However&#44; MetS is not a well-defined pathophysiological entity&#44; and the diagnostic criteria are variable and based on expert opinions &#40;<a class="elsevierStyleCrossRef" href="#bib22">22</a>&#41;&#46; The literature has debated the existence of a major trigger for MetS and its components or whether the whole is really greater than the sum of the parts&#46; Obesity emerges as an attractive candidate to explain all manifestations of MetS&#44; but the best way to measure this parameter in the MetS scenario is also debatable&#46; Some studies identified an association between abdominal obesity &#40;waist circumference&#41; and components of MetS &#40;<a class="elsevierStyleCrossRef" href="#bib23">23</a>&#44;<a class="elsevierStyleCrossRef" href="#bib24">24</a>&#41;&#44; while others showed an association with body mass index or waist-to-hip ratio &#40;<a class="elsevierStyleCrossRefs" href="#bib25">25-28</a>&#41;&#46; Regardless of the obesity parameter&#44; the importance of obesity in inducing high blood pressure and metabolic and inflammatory dysregulation is clear&#46;</p><p id="para210" class="elsevierStylePara elsevierViewall">Elevated sympathetic nervous system activity seems to be crucial to the development of obesity-related risk &#40;<a class="elsevierStyleCrossRef" href="#bib29">29</a>&#41;&#46; In our study&#44; patients with MetS and high blood pressure had higher surrogate markers of sympathetic activity&#46; Long-term sympathetic activation can lead to small artery vasoconstriction and remodeling&#44; which increases the wall-to-lumen ratio and may act synergistically with large artery damage to raise blood pressure &#40;<a class="elsevierStyleCrossRef" href="#bib30">30</a>&#41;&#46; Sympathetic activity is also related to baroreflex impairment&#44; as observed in this study&#46; However&#44; sympathetic activity may not be related only to hemodynamic impairment but also to metabolic and inflammatory dysregulation&#46;</p><p id="para220" class="elsevierStylePara elsevierViewall">In addition to the hemodynamic effects&#44; sympathetically mediated vasoconstriction may also antagonize insulin-mediated glucose uptake &#40;<a class="elsevierStyleCrossRef" href="#bib29">29</a>&#41;&#46; This theory is supported by longitudinal studies demonstrating that elevated indices of sympathetic activation precede the development of insulin resistance &#40;<a class="elsevierStyleCrossRef" href="#bib31">31</a>&#41;&#46; Jamerson et al&#46; showed that norepinephrine infusion&#44; but not angiotensin&#44; impaired insulin-stimulated glucose uptake &#40;<a class="elsevierStyleCrossRefs" href="#bib29">29-31</a>&#41;&#46; In line with the metabolic dysregulation observed in our study&#44; Lichtand et al&#46; found that autonomic nervous system dysregulation was strongly associated with MetS and its components in a large cohort of participants aged 18-65 years &#40;<a class="elsevierStyleCrossRef" href="#bib35">35</a>&#41;&#46; However&#44; these authors did not stratify patients with MetS according to blood pressure status and did not explore other risk factors not included in the MetS definition&#44; such as proinflammatory and prothrombotic markers&#46;</p><p id="para230" class="elsevierStylePara elsevierViewall">In our study&#44; we also observed that adiponectin levels were lower and that markers of inflammation were higher in MetS patients with high blood pressure than in MetS patients without high blood pressure&#46; Sympathetic activation reportedly reduces adiponectin release&#44; whereas central-sympathetic blockade may increase adiponectin levels &#40;<a class="elsevierStyleCrossRef" href="#bib36">36</a>&#41;&#46; Plasma adiponectin is inversely related to insulin resistance &#40;<a class="elsevierStyleCrossRef" href="#bib35">35</a>&#41;&#46; Thus&#44; the increased sympathetic activity in patients with MetS and high blood pressure may decrease adiponectin levels that&#44; in turn&#44; can also contribute to insulin resistance&#46; Systemic inflammation may also be linked to sympathetic activity&#46; Previous evidence found that indirect markers of sympathetic activity &#40;increased heart rate and reduced heart-rate variability&#41; were associated with subclinical inflammation in healthy middle-aged and elderly subjects&#46; These results suggest that an autonomic imbalance in favor of the sympathetic system may interact with inflammatory processes to play a more important role in the process of vascular stiffness and atherosclerosis&#46;</p><p id="para240" class="elsevierStylePara elsevierViewall">A few limitations from this investigation should be addressed&#46; First&#44; due to the study design&#44; our findings suggest an association rather than a cause-effect relationship between high blood pressure and metabolic&#44; inflammatory&#44; prothrombotic and autonomic impairments in patients with MetS&#46; Although consistent with the cited literature&#44; we cannot prove that sympathetic activity is the main obesity-related trigger underlying not only the increased blood pressure but also impairments in the metabolic&#44; inflammatory and prothrombotic profiles in this subgroup of patients with MetS&#46; Second&#44; direct measurements of peripheral sympathetic activity using microneurography were not performed&#46; However&#44; spectral analysis is an acceptable non-invasive method for estimating sympathovagal activity &#40;<a class="elsevierStyleCrossRef" href="#bib13">13</a>&#41;&#46; Our findings consistently suggest a decrease in vagal activity and the activation of the sympathetic system in the spectral analyses of both heart rate and blood pressure&#46; Third&#44; these results cannot be extrapolated to MetS patients with diabetes&#46; Finally&#44; the precise reasons by which a subset of patients with MetS had higher blood pressure and greater sympathetic activity despite similar indices of obesity are not clear&#46; Recent studies reported the potential role of psychosocial stress in inducing sympathetic activity &#40;<a class="elsevierStyleCrossRef" href="#bib29">29</a>&#44;<a class="elsevierStyleCrossRef" href="#bib37">37</a>&#44;<a class="elsevierStyleCrossRef" href="#bib38">38</a>&#41;&#46; Another potential candidate is obstructive sleep apnea&#46; This clinical condition is characterized by sympathetic activation that is independent of obesity&#44; and it is a well-established cause of high blood pressure and increased arterial stiffness &#40;<a class="elsevierStyleCrossRefs" href="#bib39">39-41</a>&#41;&#46; Recent evidence in consecutive patients with MetS suggests that obstructive sleep apnea is quite common and is independently associated with increased sympathetic activity &#40;<a class="elsevierStyleCrossRef" href="#bib41">41</a>&#41;&#44; metabolic and inflammatory dysregulation &#40;<a class="elsevierStyleCrossRef" href="#bib42">42</a>&#41; and increased markers of atherosclerosis &#40;<a class="elsevierStyleCrossRef" href="#bib43">43</a>&#41;&#46; These potential confounders should be addressed in future investigations&#46;</p><p id="para250" class="elsevierStylePara elsevierViewall">In conclusion&#44; this study provides several provocative new findings that suggest the importance of characterizing patients with MetS according to the presence or absence of high blood pressure&#46; Although we cannot prove a cause-effect relationship&#44; our results demonstrated that patients with MetS and high blood pressure have higher surrogate markers of sympathetic activity and significant metabolic&#44; inflammatory and prothrombotic impairments&#46; Thus&#44; it is reasonable to speculate that blocking sympathetic activity is an attractive strategy for treating patients with MetS&#46; A previous study showed that a combined &#945;- and &#946;-adrenergic blockade significantly reduced blood pressure in obese patients compared to lean patients with essential hypertension &#40;<a class="elsevierStyleCrossRef" href="#bib44">44</a>&#41;&#46; Moreover&#44; renal denervation&#44; which reduces sympathetic activity&#44; lowers blood pressure and reduces insulin resistance&#44; may improve obstructive sleep apnea &#40;<a class="elsevierStyleCrossRef" href="#bib45">45</a>&#41;&#46; Future studies will clarify whether pharmacological suppression of sympathetic activity in patients with MetS will improve not only blood pressure but also the metabolic&#44; inflammatory and prothrombotic dysfunctions observed in these patients&#46;</p></span><span id="cesec150" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle200">ACKNOWLEDGMENTS</span><p id="para260" class="elsevierStylePara elsevierViewall">This work was supported by grants from FAPESP &#40;Funda&#231;&#227;o de Amparo &#224; Pesquisa de S&#227;o Paulo&#41; and Zerbini Foundation&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:7 [
        0 => array:2 [
          "identificador" => "xpalclavsec1582062"
          "titulo" => "KEYWORDS"
        ]
        1 => array:2 [
          "identificador" => "cesec10"
          "titulo" => "INTRODUCTION"
        ]
        2 => array:3 [
          "identificador" => "cesec20"
          "titulo" => "METHODS"
          "secciones" => array:10 [
            0 => array:2 [
              "identificador" => "cesec30"
              "titulo" => "Study population"
            ]
            1 => array:2 [
              "identificador" => "cesec40"
              "titulo" => "Clinical evaluation"
            ]
            2 => array:2 [
              "identificador" => "cesec50"
              "titulo" => "Biochemistry measurements"
            ]
            3 => array:2 [
              "identificador" => "cesec60"
              "titulo" => "Insulin resistance"
            ]
            4 => array:2 [
              "identificador" => "cesec70"
              "titulo" => "Cytokines"
            ]
            5 => array:2 [
              "identificador" => "cesec80"
              "titulo" => "Power spectral analysis"
            ]
            6 => array:2 [
              "identificador" => "cesec90"
              "titulo" => "Baroreflex sensitivity"
            ]
            7 => array:2 [
              "identificador" => "cesec100"
              "titulo" => "Anxiety and depression evaluation"
            ]
            8 => array:2 [
              "identificador" => "cesec110"
              "titulo" => "Statistical analysis"
            ]
            9 => array:2 [
              "identificador" => "cesec120"
              "titulo" => "Ethics statement"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "cesec130"
          "titulo" => "RESULTS"
        ]
        4 => array:2 [
          "identificador" => "cesec140"
          "titulo" => "DISCUSSION"
        ]
        5 => array:2 [
          "identificador" => "cesec150"
          "titulo" => "ACKNOWLEDGMENTS"
        ]
        6 => array:1 [
          "titulo" => "REFERENCES"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2013-04-27"
    "fechaAceptado" => "2013-06-11"
    "PalabrasClave" => array:1 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "KEYWORDS"
          "identificador" => "xpalclavsec1582062"
          "palabras" => array:6 [
            0 => "Hypertension"
            1 => "Sympathetic Activity"
            2 => "Insulin Resistance"
            3 => "Inflammation"
            4 => "Prothrombosis"
            5 => "Metabolic Syndrome"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:1 [
      "en" => array:2 [
        "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">OBJECTIVES&#58;</span><p id="spara100" class="elsevierStyleSimplePara elsevierViewall">We explored whether high blood pressure is associated with metabolic&#44; inflammatory and prothrombotic dysregulation in patients with metabolic syndrome&#46;</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">METHODS&#58;</span><p id="spara110" class="elsevierStyleSimplePara elsevierViewall">We evaluated 135 consecutive overweight&#47;obese patients&#46; From this group&#44; we selected 75 patients who were not under the regular use of medications for metabolic syndrome as defined by the current Expert Panel on Detection&#44; Evaluation and Treatment of High Blood Cholesterol in Adults criteria&#46; The patients were divided into metabolic syndrome with and without high blood pressure criteria &#40;&#8805;130&#47;&#8805;85 mmHg&#41;&#46;</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">RESULTS&#58;</span><p id="spara120" class="elsevierStyleSimplePara elsevierViewall">Compared to the 45 metabolic syndrome patients without high blood pressure&#44; the 30 patients with metabolic syndrome and high blood pressure had significantly higher glucose&#44; insulin&#44; homeostasis model assessment insulin resistance index&#44; total cholesterol&#44; low-density lipoprotein-cholesterol&#44; triglycerides&#44; uric acid and creatinine values&#59; in contrast&#44; these patients had significantly lower high-density lipoprotein-cholesterol values&#46; Metabolic syndrome patients with high blood pressure also had significantly higher levels of retinol-binding protein 4&#44; plasminogen activator inhibitor 1&#44; interleukin 6 and monocyte chemoattractant protein 1 and lower levels of adiponectin&#46; Moreover&#44; patients with metabolic syndrome and high blood pressure had increased surrogate markers of sympathetic activity and decreased baroreflex sensitivity&#46; Logistic regression analysis showed that high-density lipoprotein&#44; retinol-binding protein 4 and plasminogen activator inhibitor-1 levels were independently associated with metabolic syndrome patients with high blood pressure&#46; There is a strong trend for an independent association between metabolic syndrome patients with high blood pressure and glucose levels&#46;</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">CONCLUSIONS&#58;</span><p id="spara130" class="elsevierStyleSimplePara elsevierViewall">High blood pressure&#44; which may be related to the autonomic dysfunction&#44; is associated with metabolic&#44; inflammatory and prothrombotic dysregulation in patients with metabolic syndrome&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "ceabs10"
            "titulo" => "OBJECTIVES&#58;"
          ]
          1 => array:2 [
            "identificador" => "ceabs20"
            "titulo" => "METHODS&#58;"
          ]
          2 => array:2 [
            "identificador" => "ceabs30"
            "titulo" => "RESULTS&#58;"
          ]
          3 => array:2 [
            "identificador" => "ceabs40"
            "titulo" => "CONCLUSIONS&#58;"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:1 [
        "nota" => "<p class="elsevierStyleNotepara" id="cenpara10">Gil JS conceived&#44; designed and performed the experiments&#59; analysed the data and wrote the paper&#46; Drager LF and Lopes HF conceived and designed the experiments&#44; analysed the data and wrote the paper&#46; Mostarda C performed the experiments and analysed the data&#46; Guerra-Riccio GM and Costa-Hong V performed the experiments&#46; Irigoyen MC and Bortolotto LA analysed the data&#46; Egan BM wrote the paper&#46;</p> <p class="elsevierStyleNotepara" id="cenpara20">No potential conflict of interest was reported&#46;</p>"
      ]
    ]
    "multimedia" => array:6 [
      0 => array:7 [
        "identificador" => "fig1"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 564
            "Ancho" => 795
            "Tamanyo" => 39832
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Flow diagram used to screen patients&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig2"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 309
            "Ancho" => 729
            "Tamanyo" => 11480
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Retinol-binding protein 4 levels &#40;2A&#41;&#44; plasminogen activator inhibitor 1 levels &#40;2B&#41;&#44; interleukin 6 levels &#40;2C&#41;&#44; monocyte chemoattractant protein 1 levels &#40;2D&#41; and adiponectin levels &#40;2E&#41; in metabolic syndrome - blood pressure and metabolic syndrome &#43; blood pressure subjects&#46; The results are presents as the means&#177;SD&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "t1-cln_68p1495"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">BMR&#8202;&#61;&#8202;basal metabolic rate&#59; TBW&#8202;&#61;&#8202;Total body water&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Variables&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">MetS-BP &#40;n&#8202;&#61;&#8202;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">MetS&#43;BP &#40;n&#8202;&#61;&#8202;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col"><span class="elsevierStyleItalic">p-</span>value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Age &#40;years&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#177;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&#177;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;061&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Sex &#40;F&#47;M&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&#47;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#47;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;843&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Caucasians&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32 &#40;71&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;67&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;789&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Systolic BP &#40;mmHg&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">121&#177;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">144&#177;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Diastolic BP &#40;mmHg&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76&#177;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">90&#177;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Heart Rate &#40;bpm&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#177;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">77&#177;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;081&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Body mass index &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#46;2&#177;4&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#46;5&#177;4&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;767&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Waist circumference &#40;cm&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">108&#177;10 &#40;men&#41;&#47;100&#177;11 &#40;women&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">111&#177;12 &#40;men&#41;&#47;101&#177;11 &#40;women&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;6 &#40;men&#41; 0&#46;7 &#40;women&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Waist-to-hip ratio</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;93&#177;0&#46;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;95&#177;0&#46;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;265&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Fat &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#177;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#177;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;817&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Fat mass &#40;BIA&#41;&#44; &#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#177;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#177;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;878&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Lean mass &#40;BIA&#41;&#44; &#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59&#177;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#177;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;534&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">BMR &#40;BIA&#41;&#44; kcal</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;829&#177;328&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;842&#177;398&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;743&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">TBW &#40;BIA&#41;&#44; &#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43&#177;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#177;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Demographic&#44; hemodynamic and anthropometric &#40;clinical and bioimpedance&#41; data &#40;means&#177;sd&#41; in metabolic syndrome patients without blood pressure criterion &#40;metabolic syndrome - blood pressure&#41; or with blood pressure &#40;metabolic syndrome &#43; blood pressure&#41;&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "t2-cln_68p1495"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spara60" class="elsevierStyleSimplePara elsevierViewall">PI&#8202;&#61;&#8202;Pulse interval&#59; VAR PI&#8202;&#61;&#8202;Variance of PI&#59; LF&#8202;&#61;&#8202;low frequency&#59; HF&#8202;&#61;&#8202;High frequency&#59; SBP&#8202;&#61;&#8202;Systolic blood pressure&#59; VAR SBP&#8202;&#61;&#8202;Variance of SBP&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">MetS-BP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">MetS&#43;BP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col"><span class="elsevierStyleItalic">p-</span>value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="justify" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">PI &#40;ms&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">887&#177;120&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">823&#177;126&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="justify" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">VAR PI &#40;ms<span class="elsevierStyleSup">2</span>&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2653&#177;1910&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2578&#177;1529&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="justify" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">LF &#40;ms<span class="elsevierStyleSup">2</span>&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">638&#177;607&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">671&#177;498&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="justify" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">HF &#40;ms<span class="elsevierStyleSup">2</span>&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">687&#177;563&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">590&#177;549&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="justify" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">LF &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#177;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56&#177;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="justify" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">HF &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#177;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#177;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="justify" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">LF&#47;HF</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0&#177;0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;5&#177;0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="justify" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">SBP &#40;mmHg&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">126&#177;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">141&#177;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="justify" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">VAR SBP &#40;mmHg<span class="elsevierStyleSup">2</span>&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#177;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#177;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="justify" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">LF &#40;mmHg<span class="elsevierStyleSup">2</span>&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;7&#177;4&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;0&#177;9&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="justify" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Alpha index &#40;ms&#47;mmHg&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;4&#177;5&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;7&#177;3&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara50" class="elsevierStyleSimplePara elsevierViewall">Power spectral analysis in metabolic syndrome patients without blood pressure criterion &#40;metabolic syndrome - blood pressure&#41; or with blood pressure criterion &#40;metabolic syndrome &#43; blood pressure&#41;&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "t3-cln_68p1495"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spara80" class="elsevierStyleSimplePara elsevierViewall">HDL&#8202;&#61;&#8202;High-density lipoprotein&#59; LDL&#8202;&#61;&#8202;Low-density lipoprotein&#59; HOMA-ir&#8202;&#61;&#8202;homeostasis model assessment-estimated insulin resistance index &#40;means&#177;sd&#41;&#46; Triglycerides values are reported as the medians &#40;interquartile ranges&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Variables&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">MetS-BP &#40;n&#8202;&#61;&#8202;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">MetS&#43;BP &#40;n&#8202;&#61;&#8202;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col"><span class="elsevierStyleItalic">p</span>-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Glucose &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">97&#177;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">102&#177;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Insulin &#40;U&#47;mL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;5&#177;3&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#46;5&#177;20&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">HOMA-ir</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;5&#177;1&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;4&#177;5&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">T-cholesterol &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">194&#177;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">221&#177;43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">HDL-cholesterol &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&#46;3&#177;5&#46;9 &#40;men&#41;&#47;51&#46;5&#177;10&#46;6 &#40;women&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#46;3&#177;6&#46;6 &#40;men&#41;&#47;42&#46;6&#177;7&#46;6 &#40;women&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;5 &#40;men&#41; 0&#46;002 &#40;women&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">119&#177;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">145&#177;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Triglycerides &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">150&#177;36 &#40;men&#41;&#47;124&#177;54 &#40;women&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">190&#177;78 &#40;men&#41;&#47;167&#177;57 &#40;women&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;2 &#40;men&#41; 0&#46;07 &#40;women&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Uric Acid &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;6&#177;1&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;6&#177;1&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Creatinine &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;8&#177;0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0&#177;0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara70" class="elsevierStyleSimplePara elsevierViewall">Biochemical data from metabolic syndrome patients without blood pressure criterion &#40;metabolic syndrome - blood pressure&#41; or with blood pressure criterion &#40;metabolic syndrome &#43; blood pressure&#41;&#46;</p>"
        ]
      ]
      5 => array:7 [
        "identificador" => "t4-cln_68p1495"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Variables&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Sig&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">OR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">95&#37; C&#46;I&#46; for OR</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Lower&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Upper&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">GLIC</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;118&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;057&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;125&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;996&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;270&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">HDL</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-0&#46;147&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;863&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;775&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;962&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">RBP4</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;507&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;511&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;909&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;663&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">PAI1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;270&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;311&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;103&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;558&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Constant</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-20&#46;148&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara90" class="elsevierStyleSimplePara elsevierViewall">Logistic regression analysis for variables independently associated with metabolic syndrome with high blood pressure &#40;metabolic syndrome &#43; blood pressure&#41;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "cebibsec10"
          "bibliografiaReferencia" => array:45 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Banting lecture 1988&#46; Role of insulin resistance in human disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => """
                              GM Reaven \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2337/diab.37.12.1595"
                      "Revista" => array:7 [
                        "tituloSerie" => "Diabetes"
                        "fecha" => "1988"
                        "volumen" => "37"
                        "numero" => "12"
                        "paginaInicial" => "1595"
                        "paginaFinal" => "1607"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3056758"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hematocrit levels and physiologic factors in relationship to cardiovascular risk in Tecumseh&#44; Michigan"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              S Smith \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              S Julius \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              K Jamerson \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              J Amerena \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              N Schork \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "1994"
                        "volumen" => "12"
                        "numero" => "4"
                        "paginaInicial" => "455"
                        "paginaFinal" => "462"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8064170"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk stratification in hypertension&#58; new insights from the Framingham Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => """
                              WB Kannel \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0895-7061(99)00252-6"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Hypertens"
                        "fecha" => "2000"
                        "volumen" => "13"
                        "numero" => "1Pt 2"
                        "paginaInicial" => "3S"
                        "paginaFinal" => "10S"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10678282"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New insights and approaches to reduce end-organ damage in the treatment of hypertension&#58; subsets of hypertension approach"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => """
                              MC Houston \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0002-8703(92)91042-y"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1992"
                        "volumen" => "123"
                        "numero" => "5"
                        "paginaInicial" => "1337"
                        "paginaFinal" => "1367"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1575152"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Time to re-appraise the role of alpha-1 adrenoceptor antagonists in the management of hypertension&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              N Chapman \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              CY Chen \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              T Fujita \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              FD Hobbs \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              SJ Kim \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              JA Staessen \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1097/HJH.0b013e32833b912c"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "2010"
                        "volumen" => "28"
                        "paginaInicial" => "1796"
                        "paginaFinal" => "1803"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20543713"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1097/HJH.0b013e32833b912c"
                      "Revista" => array:4 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "2010"
                        "volumen" => "28"
                        "numero" => "11"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "Third Report of the National Cholesterol Education Program &#40;NCEP&#41; Expert Panel on Detection&#44; Evaluation&#44; and Treatment of High Blood Cholesterol in Adults &#40;Adult Treatment Panel III&#41; final report"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2002"
                        "volumen" => "106"
                        "numero" => "25"
                        "paginaInicial" => "3143"
                        "paginaFinal" => "3421"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12485966"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bioelectric impedance overestimates the body fat in overweight and underestimates in Brazilian obese women&#58; a comparison with Segal equation 1"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              GD Pimentel \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              AB Bernhard \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              MR Frezza \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              AE Rinaldi \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              RC Burini \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Nutr Hosp"
                        "fecha" => "2010"
                        "volumen" => "25"
                        "numero" => "5"
                        "paginaInicial" => "741"
                        "paginaFinal" => "745"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21336430"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              HS Schipper \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              W de Jager \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              ME van Dijk \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              J Meerding \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              PM Zelissen \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              RA Adan \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1373/clinchem.2010.146118"
                      "Revista" => array:8 [
                        "tituloSerie" => "Clin Chem"
                        "fecha" => "2010"
                        "volumen" => "56"
                        "numero" => "8"
                        "paginaInicial" => "1320"
                        "paginaFinal" => "1328"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20530731"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0092867421006279"
                          "estado" => "S300"
                          "issn" => "00928674"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sleep-related changes in hemodynamic and autonomic regulation in human hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              LF Drager \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              LM Ueno \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              PS Lessa \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              CE Negr&#227;o \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              G Lorenzi-Filho \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              EM Krieger \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/HJH.0b013e32832c6982"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "2009"
                        "volumen" => "27"
                        "numero" => "8"
                        "paginaInicial" => "1655"
                        "paginaFinal" => "1663"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19451834"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              M Pagani \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              F Lombardi \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              S Guzzetti \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              O Rimoldi \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              R Furlan \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              P Pizzinelli \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.res.59.2.178"
                      "Revista" => array:7 [
                        "tituloSerie" => "Circ Res"
                        "fecha" => "1986"
                        "volumen" => "59"
                        "numero" => "2"
                        "paginaInicial" => "178"
                        "paginaFinal" => "193"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2874900"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "Heart rate variability&#58; standards of measurement&#44; physiological interpretation and clinical use&#46; Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1996"
                        "volumen" => "93"
                        "numero" => "5"
                        "paginaInicial" => "1043"
                        "paginaFinal" => "1065"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8598068"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is reduced baroreflex gain a component of the metabolic syndrome&#63; Insights from the LINOSA study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              D Lucini \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              G Cusumano \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              A Bellia \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              M Kozakova \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              G Difede \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              R Lauro \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.hjh.0000202817.02836.9c"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "2006"
                        "volumen" => "24"
                        "numero" => "2"
                        "paginaInicial" => "361"
                        "paginaFinal" => "370"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16508585"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Changes in autonomic regulation induced by physical training in mild hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              M Pagani \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              V Somers \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              R Furlan \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              S Dell&#39;Orto \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              J Conway \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              G Baselli \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.hyp.12.6.600"
                      "Revista" => array:7 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "1988"
                        "volumen" => "12"
                        "numero" => "6"
                        "paginaInicial" => "600"
                        "paginaFinal" => "610"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3203964"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The assessment of anxiety states by rating"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => """
                              M Hamilton \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.2044-8341.1959.tb00467.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Med Psychol"
                        "fecha" => "1959"
                        "volumen" => "32"
                        "numero" => "1"
                        "paginaInicial" => "50"
                        "paginaFinal" => "55"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13638508"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Hamilton Anxiety Scale&#58; reliability&#44; validity and sensitivity to change in anxiety and depressive disorders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              W Maier \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              R Buller \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              M Philipp \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              I Heuser \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0165-0327(88)90072-9"
                      "Revista" => array:8 [
                        "tituloSerie" => "J Affect Disord"
                        "fecha" => "1988"
                        "volumen" => "14"
                        "numero" => "1"
                        "paginaInicial" => "61"
                        "paginaFinal" => "68"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2963053"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0092867420306723"
                          "estado" => "S300"
                          "issn" => "00928674"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validation of the Brazilian Portuguese version of the Beck Depression Inventory-II in a community sample&#46; Rev"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              MH Gomes-Oliveira \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              C Gorenstein \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              F Lotufo Neto \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              LH Andrade \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              YP Wang \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Bras&#46; Psiquiatr"
                        "fecha" => "2012"
                        "volumen" => "34"
                        "numero" => "4"
                        "paginaInicial" => "389"
                        "paginaFinal" => "394"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Retinol-binding protein 4 and insulin resistance in lean&#44; obese&#44; and diabetic subjects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              TE Graham \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              Q Yang \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              M Bl&#252;her \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              A Hammarstedt \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              TP Ciaraldi \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              RR Henry \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa054862"
                      "Revista" => array:7 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2006"
                        "volumen" => "354"
                        "numero" => "24"
                        "paginaInicial" => "2552"
                        "paginaFinal" => "2563"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16775236"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use and abuse of HOMA modeling"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              TM Wallace \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              JC Levy \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              DR Matthews \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2337/diacare.27.6.1487"
                      "Revista" => array:7 [
                        "tituloSerie" => "Diabetes Care"
                        "fecha" => "2004"
                        "volumen" => "27"
                        "numero" => "6"
                        "paginaInicial" => "1487"
                        "paginaFinal" => "1495"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15161807"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnosis and management of the metabolic syndrome&#58; an American Heart Association&#47;National Heart&#44; Lung&#44; and Blood Institute Scientific Statement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              SM Grundy \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              JI Cleeman \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              SR Daniels \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              KA Donato \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              RH Eckel \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              RA Franklin \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/CIRCULATIONAHA.105.169404"
                      "Revista" => array:7 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2005"
                        "volumen" => "112"
                        "numero" => "17"
                        "paginaInicial" => "2735"
                        "paginaFinal" => "2752"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16157765"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Waist circumference and not body mass index explains obesity-related health risk"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              I Janssen \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              PT Katzmarzyk \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              R Ross \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ajcn/79.3.379"
                      "Revista" => array:8 [
                        "tituloSerie" => "Am J Clin Nutr"
                        "fecha" => "2004"
                        "volumen" => "79"
                        "numero" => "3"
                        "paginaInicial" => "379"
                        "paginaFinal" => "384"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14985210"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0022202X1830109X"
                          "estado" => "S300"
                          "issn" => "0022202X"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Waist circumference as a measure for indicating need for weight management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              ME Lean \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              TS Han \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              CE Morrison \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bmj.311.6998.158"
                      "Revista" => array:7 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "1995"
                        "volumen" => "311"
                        "numero" => "6998"
                        "paginaInicial" => "158"
                        "paginaFinal" => "161"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7613427"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Body mass index has a good correlation with proatherosclerotic profile in children and adolescents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              GB Costa \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              N Horta \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              ZF Resende \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              G Souza \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              LM Barreto \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              LH Correia \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/s0066-782x2009000900010"
                      "Revista" => array:7 [
                        "tituloSerie" => "Arq Bras Cardiol"
                        "fecha" => "2009"
                        "volumen" => "93"
                        "numero" => "3"
                        "paginaInicial" => "261"
                        "paginaFinal" => "267"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19851654"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Body mass index&#44; waist circumference&#44; and clustering of cardiovascular disease risk factors in a biracial sample of children and adolescents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              PT Katzmarzyk \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              SR Srinivasan \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              W Chen \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              RM Malina \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              C Bouchard \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              GS Berenson \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1542/peds.114.2.e198"
                      "Revista" => array:7 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "2004"
                        "volumen" => "114"
                        "numero" => "2"
                        "paginaInicial" => "e198"
                        "paginaFinal" => "e205"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15286257"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              HJ Schneider \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              H Glaesmer \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              J Klotsche \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              S B&#246;hler \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              H Lehnert \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              AM Zeiher \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jc.2006-0254"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2007"
                        "volumen" => "92"
                        "numero" => "2"
                        "paginaInicial" => "589"
                        "paginaFinal" => "594"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17105840"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obesity and the risk of myocardial infarction in 27&#44;000 participants from 52 countries&#58; a case-control study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              S Yusuf \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              S Hawken \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              S Ounpuu \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              L Bautista \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              MG Franzosi \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              P Commerford \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(05)67663-5"
                      "Revista" => array:7 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2005"
                        "volumen" => "366"
                        "numero" => "9497"
                        "paginaInicial" => "1640"
                        "paginaFinal" => "1649"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16271645"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stress and its role in sympathetic nervous system activation in hypertension and the metabolic syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              EA Lambert \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              GW Lambert \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11906-011-0186-y"
                      "Revista" => array:7 [
                        "tituloSerie" => "Curr Hypertens Rep"
                        "fecha" => "2011"
                        "volumen" => "13"
                        "numero" => "3"
                        "paginaInicial" => "244"
                        "paginaFinal" => "248"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21271362"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanisms of obesity-induced hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              V Kotsis \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              S Stabouli \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              S Papakatsika \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              Z Rizos \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              G Parati \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/hr.2010.9"
                      "Revista" => array:7 [
                        "tituloSerie" => "Hypertens Res"
                        "fecha" => "2010"
                        "volumen" => "33"
                        "numero" => "5"
                        "paginaInicial" => "386"
                        "paginaFinal" => "393"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20442753"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased sympathetic reactivity may predict insulin resistance&#58; an 18-year follow-up study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              A Flaa \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              TA Aksnes \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              SE Kjeldsen \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              I Eide \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              M Rostrup \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.metabol.2008.05.012"
                      "Revista" => array:7 [
                        "tituloSerie" => "Metabolism"
                        "fecha" => "2008"
                        "volumen" => "57"
                        "numero" => "10"
                        "paginaInicial" => "1422"
                        "paginaFinal" => "1427"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18803948"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Angiotensin mediates forearm glucose uptake by hemodynamic rather than direct effects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              KA Jamerson \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              SD Nesbitt \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              JV Amerena \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              E Grant \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              S Julius \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.hyp.27.4.854"
                      "Revista" => array:7 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "1996"
                        "volumen" => "27"
                        "numero" => "4"
                        "paginaInicial" => "854"
                        "paginaFinal" => "858"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8613260"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vasoconstriction with norepinephrine causes less forearm insulin resistance than a reflex sympathetic vasoconstriction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              KA Jamerson \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              SD Smith \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              JV Amerena \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              E Grant \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              S Julius \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.hyp.23.6.1006"
                      "Revista" => array:7 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "1994"
                        "volumen" => "23"
                        "numero" => "6 Pt 2"
                        "paginaInicial" => "1006"
                        "paginaFinal" => "1011"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8206583"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Application of prazosin is associated with an increase of insulin sensitivity in obese patients with hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              T Pollare \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              H Lithell \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              I Selinus \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              C Berne \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF00271585"
                      "Revista" => array:7 [
                        "tituloSerie" => "Diabetologia"
                        "fecha" => "1988"
                        "volumen" => "31"
                        "numero" => "7"
                        "paginaInicial" => "415"
                        "paginaFinal" => "420"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3065104"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased sympathetic and decreased parasympathetic activity rather than changes in hypothalamic-pituitary-adrenal axis activity is associated with metabolic abnormalities"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              CM Licht \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              SA Vreeburg \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              AK van Reedt Dortland \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              EJ Giltay \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              WJ Hoogendijk \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              RH DeRijk \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jc.2009-2801"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2010"
                        "volumen" => "95"
                        "numero" => "5"
                        "paginaInicial" => "2458"
                        "paginaFinal" => "2466"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20237163"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypoadiponectinemia in obesity and type 2 diabetes&#58; close association with insulin resistance and hyperinsulinemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              C Weyer \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              T Funahashi \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              S Tanaka \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              K Hotta \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              Y Matsuzawa \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              RE Pratley \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem.86.5.7463"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2001"
                        "volumen" => "86"
                        "numero" => "5"
                        "paginaInicial" => "1930"
                        "paginaFinal" => "1935"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11344187"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association between the sympathetic firing pattern and anxiety level in patients with the metabolic syndrome and elevated blood pressure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              E Lambert \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              T Dawood \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              N Straznicky \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              C Sari \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              M Schlaich \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              M Esler \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/HJH.0b013e3283350ea4"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "2010"
                        "volumen" => "28"
                        "numero" => "3"
                        "paginaInicial" => "543"
                        "paginaFinal" => "550"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20139772"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Changes in plasma lipids with psychosocial stress are related to hypertension status and the norepinephrine stress response"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              PH Wirtz \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              U Ehlert \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              C Bartschi \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              LS Redwine \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              R von Kanel \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.metabol.2008.08.003"
                      "Revista" => array:7 [
                        "tituloSerie" => "Metabolism"
                        "fecha" => "2009"
                        "volumen" => "58"
                        "numero" => "1"
                        "paginaInicial" => "30"
                        "paginaFinal" => "37"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19059528"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Seventh report of the Joint National Committee on Prevention&#44; Detection&#44; Evaluation&#44; and Treatment of High Blood Pressure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              AV Chobanian \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              GL Bakris \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              HR Black \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              WC Cushman \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              LA Green \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              JL Izzo Jr \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.HYP.0000107251.49515.c2"
                      "Revista" => array:7 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2003"
                        "volumen" => "42"
                        "numero" => "6"
                        "paginaInicial" => "1206"
                        "paginaFinal" => "1252"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14656957"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of continuous positive airway pressure on early signs of atherosclerosis in obstructive sleep apnea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              LF Drager \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              LA Bortolotto \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              AC Figueiredo \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              EM Krieger \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              GF Lorenzi \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200703-500OC"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2007"
                        "volumen" => "176"
                        "numero" => "7"
                        "paginaInicial" => "706"
                        "paginaFinal" => "712"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17556718"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Consequences of comorbid sleep apnea in the metabolic syndrome-implications for cardiovascular risk"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              IC Trombetta \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              VK Somers \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              C Maki-Nunes \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              LF Drager \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              E Toschi-Dias \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              MJ Alves \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/sleep/33.9.1193"
                      "Revista" => array:7 [
                        "tituloSerie" => "Sleep"
                        "fecha" => "2010"
                        "volumen" => "33"
                        "numero" => "9"
                        "paginaInicial" => "1193"
                        "paginaFinal" => "1199"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20857866"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The impact of obstructive sleep apnea on metabolic and inflammatory markers in consecutive patients with metabolic syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              LF Drager \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              HF Lopes \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              C Maki-Nunes \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              IC Trombetta \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              E Toschi-Dias \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              MJ Alves \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "PLoS One"
                        "fecha" => "2010"
                        "volumen" => "5"
                        "numero" => "8"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib40"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obstructive sleep apnea&#44; hypertension&#44; and their interaction on arterial stiffness and heart remodeling"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              LF Drager \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              LA Bortolotto \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              AC Figueiredo \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              BC Silva \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              EM Krieger \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              G Lorenzi-Filho \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.06-2703"
                      "Revista" => array:7 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2007"
                        "volumen" => "131"
                        "numero" => "5"
                        "paginaInicial" => "1379"
                        "paginaFinal" => "1386"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17494787"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib41"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antihypertensive effect of alpha- and beta-adrenergic blockade in obese and lean hypertensive subjects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              MR Wofford \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              DC Anderson Jr \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              CA Brown \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              DW Jones \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              ME Miller \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              JE Hall \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0895-7061(01)01293-6"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Hypertens"
                        "fecha" => "2001"
                        "volumen" => "14"
                        "numero" => "7 Pt 1"
                        "paginaInicial" => "694"
                        "paginaFinal" => "698"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11465655"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib42"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of renal sympathetic denervation on blood pressure&#44; sleep apnea course&#44; and glycemic control in patients with resistant hypertension and sleep apnea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              A Witkowski \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              A Prejbisz \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              E Florczak \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              J K&#260;dziela \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              P &#346;liwi&#324;ski \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              P Bielen \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/HYPERTENSIONAHA.111.173799"
                      "Revista" => array:7 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2011"
                        "volumen" => "58"
                        "numero" => "4"
                        "paginaInicial" => "559"
                        "paginaFinal" => "565"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21844482"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib43"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The incremental role of obstructive sleep apnoea on markers of atherosclerosis in patients with metabolic syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              LF Drager \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              LA Bortolotto \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              C Maki-Nunes \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              IC Trombetta \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              MJ Alves \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              RF Fraga \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.atherosclerosis.2009.08.016"
                      "Revista" => array:7 [
                        "tituloSerie" => "Atherosclerosis"
                        "fecha" => "2010"
                        "volumen" => "208"
                        "numero" => "2"
                        "paginaInicial" => "490"
                        "paginaFinal" => "495"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19762024"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib44"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antihypertensive effect of alpha- and beta-adrenergic blockade in obese and lean hypertensive subjects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              MR Wofford \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              DC Anderson Jr \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              CA Brown \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              DW Jones \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              ME Miller \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              JE Hall \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0895-7061(01)01293-6"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Hypertens"
                        "fecha" => "2001"
                        "volumen" => "14"
                        "numero" => "7 Pt 1"
                        "paginaInicial" => "694"
                        "paginaFinal" => "698"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11465655"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib45"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of renal sympathetic denervation on blood pressure&#44; sleep apnea course&#44; and glycemic control in patients with resistant hypertension and sleep apnea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              A Witkowski \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              A Prejbisz \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              E Florczak \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              J Kadziela \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              P Sliwinski \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              P Bielen \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/HYPERTENSIONAHA.111.173799"
                      "Revista" => array:7 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2011"
                        "volumen" => "58"
                        "numero" => "4"
                        "paginaInicial" => "559"
                        "paginaFinal" => "565"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21844482"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/18075932/0000006800000012/v1_202212011241/S1807593222020361/v1_202212011241/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/18075932/0000006800000012/v1_202212011241/S1807593222020361/v1_202212011241/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222020361?idApp=UINPBA00004N"
]

Article information

ISSN: 18075932
Original language: English

DOI:10.6061/clinics/2013(12)04

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	7	2	9
2024 October	27	22	49
2024 September	28	20	48
2024 August	26	16	42
2024 July	29	13	42
2024 June	23	12	35
2024 May	46	11	57
2024 April	32	10	42
2024 March	37	12	49
2024 February	36	15	51
2024 January	12	10	22
2023 December	20	13	33
2023 November	34	21	55
2023 October	17	25	42
2023 September	40	22	62
2023 August	23	8	31
2023 July	14	17	31
2023 June	28	10	38
2023 May	37	0	37
2023 April	37	1	38
2023 March	50	1	51
2023 February	7	1	8
2023 January	4	2	6
2022 December	35	1	36

Show all

Indexed in:

Follow us:

Statistics

Indexed in:

Follow us:

Statistics

Subscribe to our newsletter