metricas
covid
Buscar en
Clinics
Toda la web
Inicio Clinics Autonomic dysfunction and beta blocker therapy in Chagas heart disease
Journal Information

Statistics

Follow this link to access the full text of the article

READERS OPINION
Autonomic dysfunction and beta blocker therapy in Chagas heart disease
Reinaldo B BestettiI,
Corresponding author
rbestetti@netsite.com.br

Tel.: 55 16 3603-7013
, Augusto Cardinalli-NetoII
I UNAERP Medical School, Ribeirão Preto/SP, Brazil
II Hospital de Base, São José do Rio Preto/SP, Brazil.
Read
765
Times
was read the article
318
Total PDF
447
Total HTML
Share statistics
 array:24 [
  "pii" => "S1807593222021135"
  "issn" => "18075932"
  "doi" => "10.6061/clinics/2013(02)LE01"
  "estado" => "S300"
  "fechaPublicacion" => "2013-01-01"
  "aid" => "2113"
  "copyright" => "CLINICS"
  "copyrightAnyo" => "2013"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
  "subdocumento" => "fla"
  "cita" => "Clinics. 2013;68:275"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1807593222021147"
    "issn" => "18075932"
    "doi" => "10.6061/clinics/2013(02)RC01"
    "estado" => "S300"
    "fechaPublicacion" => "2013-01-01"
    "aid" => "2114"
    "copyright" => "CLINICS"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
    "subdocumento" => "fla"
    "cita" => "Clinics. 2013;68:277-80"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">RAPID COMMUNICATION</span>"
      "titulo" => "Single-nucleotide polymorphisms of <span class="elsevierStyleItalic">GSK3B&#44; GAB2</span> and <span class="elsevierStyleItalic">SORL1</span> in late-onset Alzheimer&#39;s disease&#58; interactions with the <span class="elsevierStyleItalic">APOE</span> genotype"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "277"
          "paginaFinal" => "280"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Giselle Izzo, Orestes V&#46; Forlenza, Bernardo dos Santos, Paulo H&#46;F&#46; Bertolucci, Elida B&#46; Ojopi, Wagner F&#46; Gattaz, Daniel Shikanai Kerr"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Giselle"
              "apellidos" => "Izzo"
            ]
            1 => array:2 [
              "nombre" => "Orestes V&#46;"
              "apellidos" => "Forlenza"
            ]
            2 => array:2 [
              "nombre" => "Bernardo"
              "apellidos" => "dos Santos"
            ]
            3 => array:2 [
              "nombre" => "Paulo H&#46;F&#46;"
              "apellidos" => "Bertolucci"
            ]
            4 => array:2 [
              "nombre" => "Elida B&#46;"
              "apellidos" => "Ojopi"
            ]
            5 => array:2 [
              "nombre" => "Wagner F&#46;"
              "apellidos" => "Gattaz"
            ]
            6 => array:2 [
              "nombre" => "Daniel Shikanai"
              "apellidos" => "Kerr"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222021147?idApp=UINPBA00004N"
    "url" => "/18075932/0000006800000002/v1_202212011614/S1807593222021147/v1_202212011614/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1807593222021123"
    "issn" => "18075932"
    "doi" => "10.6061/clinics/2013(02)R01"
    "estado" => "S300"
    "fechaPublicacion" => "2013-01-01"
    "aid" => "2112"
    "copyright" => "CLINICS"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
    "subdocumento" => "rev"
    "cita" => "Clinics. 2013;68:269-74"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">REVIEW</span>"
      "titulo" => "Muscle residual force enhancement&#58; a brief review"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "269"
          "paginaFinal" => "274"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig1"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "cln-68-02-269-g001.jpeg"
              "Alto" => 527
              "Ancho" => 796
              "Tamanyo" => 18666
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Schematic representation of muscle residual force enhancement&#46; Both panels show two representative superimposed contractions from the same muscle as it is first activated&#44; stretched to a certain final length&#44; relaxed &#40;solid lines&#41;&#44; and then isometrically activated and kept at the same final length before being relaxed again &#40;dashed lines&#41;&#46; Top panel&#58; force traces&#46; Bottom panel&#58; length traces&#46; FE&#58; force enhancement&#46; PFE&#58; passive force enhancement&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "F&#225;bio Carderelli Minozzo, Claudio Andre Barbosa de Lira"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "F&#225;bio Carderelli"
              "apellidos" => "Minozzo"
            ]
            1 => array:2 [
              "nombre" => "Claudio Andre Barbosa"
              "apellidos" => "de Lira"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222021123?idApp=UINPBA00004N"
    "url" => "/18075932/0000006800000002/v1_202212011614/S1807593222021123/v1_202212011614/en/main.assets"
  ]
  "en" => array:11 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">READERS OPINION</span>"
    "titulo" => "Autonomic dysfunction and beta blocker therapy in Chagas heart disease"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:1 [
        "paginaInicial" => "275"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Reinaldo B Bestetti, Augusto Cardinalli-Neto"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "Reinaldo B"
            "apellidos" => "Bestetti"
            "email" => array:1 [
              0 => "rbestetti@netsite.com.br"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Augusto"
            "apellidos" => "Cardinalli-Neto"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">II</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "UNAERP Medical School&#44; Ribeir&#227;o Preto&#47;SP&#44; Brazil"
            "etiqueta" => "I"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Hospital de Base&#44; S&#227;o Jos&#233; do Rio Preto&#47;SP&#44; Brazil&#46;"
            "etiqueta" => "II"
            "identificador" => "aff2"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#42;"
            "correspondencia" => "Tel&#46;&#58; 55 16 3603-7013"
          ]
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="para10" class="elsevierStylePara elsevierViewall">In a hamster model of Chagas disease&#44; Pimentel et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib1">1</a>&#41; recently found that 1&#41; carvedilol decreased mortality in the acute&#44; but not in the chronic stage and 2&#41; in the chronic stage&#44; carvedilol neither changed the left ventricular diameter and&#47;or function&#44; nor attenuated changes in the resting electrocardiogram &#40;ECG&#41;&#44; nor decreased the myocardial collagen content&#46;</p><p id="para20" class="elsevierStylePara elsevierViewall">In contrast&#44; we did not observe a decrease in the mortality rate of rats that were infected with <span class="elsevierStyleItalic">Trypanosoma cruzi</span> and then received metoprolol to treat the ensuing acute Chagas disease &#40;<a class="elsevierStyleCrossRef" href="#bib2">2</a>&#41;&#46; Conceivably&#44; both the animal model and the <span class="elsevierStyleItalic">T&#46; cruzi</span> strain might account for this disparity&#46; Furthermore&#44; we found that chronic metoprolol administration reversed the ECG abnormalities in the <span class="elsevierStyleItalic">T&#46; cruzi</span>-infected rats at the chronic stage of the disease&#46; Left axis deviations and intraventricular conduction delays have been observed in almost half of rats chronically infected with <span class="elsevierStyleItalic">T&#46; cruzi</span>&#44; which we believe supports the theory that the different animal models used in the two studies were responsible for the different results&#46;</p><p id="para30" class="elsevierStylePara elsevierViewall">Pimentel et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib1">1</a>&#41; did not observe any effects of the chronic use of carvedilol on myocardial function and left ventricular remodeling in their hamster model of chronic Chagas heart disease&#46; Although there are no other studies for comparison&#44; we agree with the assertion of Pimentel et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib1">1</a>&#41; that intense myocarditis&#44; extensive myocardial fibrosis&#44; and sympathetic denervation may have overshadowed the beneficial effects of the beta blocker therapy in this animal model&#46;</p><p id="para40" class="elsevierStylePara elsevierViewall">Our message is that the absence of a beneficial effect of carvedilol use in a hamster model should not preclude the use of beta blockers in Chagas disease patients&#44; particularly in the following two clinical settings&#46; First&#44; beta blockers may be appropriate for patients with chronic systolic heart failure because the activation of the autonomic nervous system in these patients is similar to that observed in heart failure patients without Chagas disease &#40;<a class="elsevierStyleCrossRef" href="#bib3">3</a>&#41; and because beta blocker therapy has produced good preliminary results in this group of patients &#40;<a class="elsevierStyleCrossRefs" href="#bib4">4-</a>&#41;&#40;<a class="elsevierStyleCrossRef" href="#bib7">7</a>&#41;&#46; Second&#44; beta blocker therapy may be suitable for patients receiving implantable cardioverter-defibrillator therapy for the secondary prevention of sudden cardiac death due to the high recurrence rate of malignant arrhythmias in this patient group in the absence of beta blocker therapy &#40;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#41;&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:1 [
        "nota" => "<p class="elsevierStyleNotepara" id="cenpara10">No potential conflict of interest was reported&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "cebibsec10"
          "bibliografiaReferencia" => array:8 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of beta-blockade on myocardial remodeling in Chagas cardiomyopathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              WS Pimentel \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              FJA Ramires \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              BM Ianni \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              VMC Salemi \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              AMB Bilate \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              E Cunha-Neto \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clinics"
                        "fecha" => "2012"
                        "volumen" => "67"
                        "numero" => "9"
                        "paginaInicial" => "9"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pinto LZ&#44; Soares EG&#44; Muccillo G&#44; Oliveira JSM&#46; Effects of long-term metoprolol administration on the electrocardiogram of rats infected with T&#46; cruzi"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              RB Bestetti \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              VN Sales-Neto \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/cvr/24.1.7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiovasc Res"
                        "fecha" => "1990"
                        "volumen" => "24"
                        "numero" => "7"
                        "paginaInicial" => "7"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2183936"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Peripheral and coronary sinus catecholamine levels in patients with severe congestive heart failure due to Chagas disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              RB Bestetti \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              J Coutinho-Neto \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              L Staibano \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              LZ Pinto \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              G Muccillo \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              JSM Oliveira \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cardiology"
                        "fecha" => "1995"
                        "volumen" => "86"
                        "numero" => "3"
                        "paginaInicial" => "6"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A randomized trial of carvedilol after renin-angiotensin system inhibition in chronic Chagas cardiomyopathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              FA Botoni \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              PA Poole-Wilson \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              ALP Ribeiro \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              DO Okonko \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              BMR Oliveira \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              AS Pinto \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "2007"
                        "volumen" => "153"
                        "numero" => "4"
                        "paginaInicial" => "8"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of metoprolol in chagasic patients with severe congestive heart failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              DF D&#225;vila \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              F Angel \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              GA Bellabarba \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              JH Donis \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Int J Cardiol"
                        "fecha" => "2002"
                        "volumen" => "85&#40;2-3&#41;"
                        "paginaInicial" => "60"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of B-Blockers on outcome of patients with Chagas&#39;cardiomyopathy with chronic heart failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              RB Bestetti \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              AP Otaviano \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              A Cardinalli-Neto \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              BF da Rocha \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              TA Theodoropoulos \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              JA Cordeiro \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Cardiol"
                        "fecha" => "2011"
                        "volumen" => "151"
                        "numero" => "2"
                        "paginaInicial" => "8"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Beta-blocker therapy and mortality of patients with Chagas cardiomyopathy&#58; a subanalysis of the REMADHE prospective trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              VS Issa \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              AF Amaral \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              FD Cruz \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              SM Ferreira \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              GV Guimar&#227;es \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              PR Chizzola \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Circ Heart Fail"
                        "fecha" => "2010"
                        "volumen" => "3"
                        "paginaInicial" => "8"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictors of all-cause mortality for patients with chronic Chagas heart disease receiving implantable cardioverter-defibrillator therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              A Cardinalli-Neto \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              RB Bestetti \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              JA Cordeiro \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              VC Rodrigues \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Cardiovasc Electrophysiol"
                        "fecha" => "2007"
                        "volumen" => "18"
                        "numero" => "12"
                        "paginaInicial" => "40"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/18075932/0000006800000002/v1_202212011614/S1807593222021135/v1_202212011614/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/18075932/0000006800000002/v1_202212011614/S1807593222021135/v1_202212011614/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222021135?idApp=UINPBA00004N"
]
Article information
ISSN: 18075932
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 6 2 8
2024 October 18 18 36
2024 September 18 11 29
2024 August 27 16 43
2024 July 16 20 36
2024 June 27 18 45
2024 May 31 14 45
2024 April 19 10 29
2024 March 14 13 27
2024 February 13 10 23
2024 January 9 17 26
2023 December 13 22 35
2023 November 17 24 41
2023 October 17 25 42
2023 September 14 29 43
2023 August 8 4 12
2023 July 17 23 40
2023 June 12 12 24
2023 May 35 4 39
2023 April 42 2 44
2023 March 24 3 27
2023 February 22 14 36
2023 January 4 0 4
2022 December 24 7 31
Show all

Follow this link to access the full text of the article

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos