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Pacheco, Karoline Dalla Rosa" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Renato" "apellidos" => "Seligman" ] 1 => array:2 [ "nombre" => "Luis Francisco" "apellidos" => "Ramos-Lima" ] 2 => array:2 [ "nombre" => "Vivian" "apellidos" => "do Amaral Oliveira" ] 3 => array:2 [ "nombre" => "Carina" "apellidos" => "Sanvicente" ] 4 => array:2 [ "nombre" => "Elyara F." "apellidos" => "Pacheco" ] 5 => array:2 [ "nombre" => "Karoline Dalla" "apellidos" => "Rosa" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222022049?idApp=UINPBA00004N" "url" => "/18075932/0000006700000011/v1_202212011245/S1807593222022049/v1_202212011245/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1807593222022025" "issn" => "18075932" "doi" => "10.6061/clinics/2012(11)15" "estado" => "S300" "fechaPublicacion" => "2012-01-01" "aid" => "2202" "copyright" => "CLINICS" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "fla" "cita" => "Clinics. 2012;67:1309-14" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">BASIC RESEARCH</span>" "titulo" => "Comparison of Celsior and Perfadex lung preservation solutions in rat lungs subjected to 6 and 12 hours of ischemia using an <span class="elsevierStyleItalic">ex-vivo</span> lung perfusion system" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1309" "paginaFinal" => "1314" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig3" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "cln-67-11-1309-g003.jpeg" "Alto" => 533 "Ancho" => 755 "Tamanyo" => 26688 ] ] "descripcion" => array:1 [ "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Airway resistance of rat lungs subjected to ischemia and reperfusion for 60 minutes. The Celsior lungs exhibited the lowest airway resistance for both ischemic times. The airway resistance was lower in lungs submitted to 6 hours of ischemia compared with those submitted to 12 hours of ischemia.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Arteiro Queiroz Menezes, Paulo Manuel Pêgo-Fernandes, Paulo Francisco Guerreiro Cardoso, Karina Andrighetti de Oliveira Braga, Natalia Aparecida Nepomuceno, Rogerio Pazetti, Aristides Tadeu Correia, Mauro Canzian, Jacqueline Klarosk Santim, Fabio Biscegli Jatene" "autores" => array:10 [ 0 => array:2 [ "nombre" => "Arteiro Queiroz" "apellidos" => "Menezes" ] 1 => array:2 [ "nombre" => "Paulo Manuel" "apellidos" => "Pêgo-Fernandes" ] 2 => array:2 [ "nombre" => "Paulo Francisco Guerreiro" "apellidos" => "Cardoso" ] 3 => array:2 [ "nombre" => "Karina Andrighetti" "apellidos" => "de Oliveira Braga" ] 4 => array:2 [ "nombre" => "Natalia Aparecida" "apellidos" => "Nepomuceno" ] 5 => array:2 [ "nombre" => "Rogerio" "apellidos" => "Pazetti" ] 6 => array:2 [ "nombre" => "Aristides Tadeu" "apellidos" => "Correia" ] 7 => array:2 [ "nombre" => "Mauro" "apellidos" => "Canzian" ] 8 => array:2 [ "nombre" => "Jacqueline Klarosk" "apellidos" => "Santim" ] 9 => array:2 [ "nombre" => "Fabio Biscegli" "apellidos" => "Jatene" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222022025?idApp=UINPBA00004N" "url" => "/18075932/0000006700000011/v1_202212011245/S1807593222022025/v1_202212011245/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">REVIEW</span>" "titulo" => "Quality of life measurements in patients with osteoporosis and fractures" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1315" "paginaFinal" => "1320" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Melisa M. Madureira, Rozana M. Ciconelli, Rosa M.R. Pereira" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Melisa M." "apellidos" => "Madureira" "email" => array:1 [ 0 => "melisamadureira@uol.com.br" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Rozana M." "apellidos" => "Ciconelli" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">II</span>" "identificador" => "aff2" ] ] ] 2 => array:4 [ "nombre" => "Rosa M.R." "apellidos" => "Pereira" "email" => array:1 [ 0 => "rosamariarp@yahoo.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Faculdade de Medicina da Universidade de São Paulo, Rheumatology Division, Bone Laboratory Metabolism, São Paulo/SP, Brazil." "etiqueta" => "I" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Universidade Federal de São Paulo, São Paulo/SP, Brazil." "etiqueta" => "II" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Tel.: 55 11 3061-721355 11 3061-7490" ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">INTRODUCTION</span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">Defining quality of life</span><p id="para10" class="elsevierStylePara elsevierViewall">The World Health Organization Quality of Life (WHOQOL) project was initiated in 1991. The aim of the project was to develop an international cross-cultural quality of life assessment instrument. The WHOQOL instrument assesses individual perceptions in the context of culture, value systems, personal goals, standards, and concerns (<a class="elsevierStyleCrossRef" href="#bib1">1</a>). This definition demonstrates that quality of life should not be measured by the frequency with which a medical service is offered to the patient but by the degree to which the results obtained serve the purposes of prolonging life, easing pain, restoring function, and preventing incapacity (<a class="elsevierStyleCrossRef" href="#bib2">2</a>).</p><p id="para20" class="elsevierStylePara elsevierViewall">Two major developments in the health field are recognizing the importance of patient-based disease evaluations and the importance of assessing the quality of the therapeutic measures being employed (<a class="elsevierStyleCrossRef" href="#bib3">3</a>).</p><p id="para30" class="elsevierStylePara elsevierViewall">Assessing functional status and quality of life has been considered central to evaluating disease progression and developing new treatments, particularly in chronic diseases such as osteoporosis (<a class="elsevierStyleCrossRef" href="#bib4">4</a>). Assessing quality of life in osteoporosis is commonly used as an outcome measure secondary to the biomechanical and radiographic evaluations following each fracture event (<a class="elsevierStyleCrossRef" href="#bib5">5</a>),(<a class="elsevierStyleCrossRef" href="#bib6">6</a>).</p><p id="para40" class="elsevierStylePara elsevierViewall">Quality of life encompasses various facets of life, including health status, environment, financial aspects and human aspects. Health status is a subset of quality of life that covers physical, mental, and social well-being (<a class="elsevierStyleCrossRef" href="#bib5">5</a>),(<a class="elsevierStyleCrossRef" href="#bib7">7</a>).</p><p id="para50" class="elsevierStylePara elsevierViewall">To measure quality of life is to assess subjective feelings objectively. Using quality-of-life questionnaires, we can evaluate treatment effects in clinical trials (<a class="elsevierStyleCrossRef" href="#bib5">5</a>),(<a class="elsevierStyleCrossRef" href="#bib8">8</a>),(<a class="elsevierStyleCrossRef" href="#bib9">9</a>). Questionnaires have been used in epidemiological studies to assess quality of life and to obtain data regarding disease severity, disease morbidity, health care, and treatment (<a class="elsevierStyleCrossRef" href="#bib5">5</a>),(<a class="elsevierStyleCrossRef" href="#bib6">6</a>).</p><p id="para60" class="elsevierStylePara elsevierViewall">In this review, we describe the characteristics and specific indications for osteoporosis quality of life questionnaires. The purpose of the present article was to discuss the adequacy of these questionnaires and their best indication according to osteoporosis clinical studies.</p></span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">Quality of life and osteoporosis</span><p id="para70" class="elsevierStylePara elsevierViewall">Assessing health-related quality of life has been considered an important marker of the clinical evolution of patients with osteoporosis and fractures (<a class="elsevierStyleCrossRef" href="#bib9">9</a>)-(<a class="elsevierStyleCrossRef" href="#bib13">13</a>). In addition, this assessment is central to health science research and clinical trials. Physical, emotional, and psychological incapacity, combined with the pain that results from hip, spine, or wrist fractures, can alter quality of life (<a class="elsevierStyleCrossRef" href="#bib14">14</a>).</p><p id="para80" class="elsevierStylePara elsevierViewall">After a hip fracture, only 25% of individuals return to their activities of daily living, such as cooking or going to the mall (<a class="elsevierStyleCrossRef" href="#bib15">15</a>). The loss of independence that results from the inability to walk (caused by functional limitations or by the fear of falling) is the principal consequence of a hip fracture. This inactivity worsens osteoporosis and increases the risks of falling and suffering new fractures (<a class="elsevierStyleCrossRef" href="#bib16">16</a>).</p><p id="para90" class="elsevierStylePara elsevierViewall">The functional alterations caused by a vertebral fracture can reduce the ability of patients to perform the activities of daily living at home and care for themselves, which increases the fear of falling and the risk of new fractures (<a class="elsevierStyleCrossRef" href="#bib17">17</a>),(<a class="elsevierStyleCrossRef" href="#bib18">18</a>). Vertebral fractures are present in approximately one third of the elderly Brazilian population (<a class="elsevierStyleCrossRef" href="#bib19">19</a>). Vertebral fractures are strongly associated with lumbar pain and functional limitations (<a class="elsevierStyleCrossRef" href="#bib20">20</a>),(<a class="elsevierStyleCrossRef" href="#bib21">21</a>). In addition, such fractures reduce lung, heart, stomach, and urinary capacities, thereby significantly reducing the quality of life (<a class="elsevierStyleCrossRef" href="#bib22">22</a>).</p><p id="para100" class="elsevierStylePara elsevierViewall">During the period following a wrist fracture, the individual can experience pain and movement limitations. Certain activities may be restricted, and such individuals could have chronic pain and reduced functions (<a class="elsevierStyleCrossRef" href="#bib23">23</a>).</p><p id="para110" class="elsevierStylePara elsevierViewall">Fracture events can affect the physical and mental domains of quality of life to different degrees depending on the type and severity of the fracture (<a class="elsevierStyleCrossRef" href="#bib24">24</a>). Fracture patients experience psychological sequelae, such as anxiety, fear, depression, reduced self-esteem, and social isolation (<a class="elsevierStyleCrossRef" href="#bib8">8</a>).</p><p id="para120" class="elsevierStylePara elsevierViewall">By measuring quality of life, we can predict clinical evolution and functional changes, as well as understand the conditions that will lead to developing better osteoporosis treatments, thereby improving patient health, reversing bone loss and reducing the risk of fractures.</p><p id="para130" class="elsevierStylePara elsevierViewall">Therefore, the search for osteoporosis-targeted questionnaires is essential to monitor and therapeutically evaluate individuals who suffer from this metabolic bone disease.</p></span></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle50">MATERIALS AND METHODS</span><p id="para140" class="elsevierStylePara elsevierViewall">The systematic search for quality of life questionnaires was conducted in Medline, the Scientific Electronic Library Online database, and the Latin-American and Caribbean Health Sciences Literature database; data over the last 20 years (January 1991-Janauary 2011) was searched using the following MeSH terms: osteoporosis, quality of life, questionnaires, and instruments.</p><span id="cesec50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle60">Specific instruments</span><p id="para150" class="elsevierStylePara elsevierViewall">In recent decades, specific instruments that measure quality of life in osteoporosis patients have been developed. Nine questionnaires were initially developed, and another five were derived from those nine.</p></span><span id="cesec60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">Women's Health Questionnaire</span><p id="para160" class="elsevierStylePara elsevierViewall">The Women's Health Questionnaire (WHQ) was developed to evaluate menopausal and postmenopausal women (<a class="elsevierStyleCrossRef" href="#bib25">25</a>). It covers specific symptoms that are observed during this phase of life. The WHQ is reproducible and exhibits excellent correlations with estrogen levels and other quality-of-life scales (<a class="elsevierStyleCrossRef" href="#bib8">8</a>),(<a class="elsevierStyleCrossRef" href="#bib26">26</a>). The WHQ has been tested for its ability to assess the efficacy of interventions and has exhibited high sensitivity for detecting changes in specific symptoms that are associated with quality of life after patients undergo medical or non-medical treatments (<a class="elsevierStyleCrossRef" href="#bib27">27</a>).</p></span><span id="cesec70" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">Osteoporosis Quality of Life Questionnaire</span><p id="para170" class="elsevierStylePara elsevierViewall">The Osteoporosis Quality of Life Questionnaire (OQLQ) is administered during an approximately 20-min interview. The questionnaire consists of 30 items that are distributed into five domains: symptoms, physical function, activities of daily living, emotional function, and leisure. All of the patients selected for the OQLQ development were diagnosed with chronic lower back pain (<a class="elsevierStyleCrossRef" href="#bib28">28</a>) and osteoporosis and had previously suffered moderate or severe vertebral fractures (<a class="elsevierStyleCrossRef" href="#bib11">11</a>). The OQLQ is used to evaluate pharmacological treatments and physical rehabilitation programs. Studies have reported that this questionnaire correlates well with generic measures and fractures and is able to detect health improvements or disabilities (<a class="elsevierStyleCrossRef" href="#bib17">17</a>).</p></span><span id="cesec80" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">Mini-Osteoporosis Quality of Life Questionnaire</span><p id="para180" class="elsevierStylePara elsevierViewall">The Mini-Osteoporosis Quality of Life Questionnaire (mini-OQLQ) was developed to reduce the time needed in clinical practice to apply the OQLQ (<a class="elsevierStyleCrossRef" href="#bib29">29</a>). The mini-OQLQ is a 10-item abbreviated form of the original 30-item OQLQ. Nevertheless, the mini-OQLQ comprises the same five domains: symptoms, physical function, activities of daily living, emotional function, and leisure. The mini-OQLQ is a self-reported questionnaire that requires approximately 3 min to complete.</p></span><span id="cesec90" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle100">Osteoporosis Assessment Questionnaire</span><p id="para190" class="elsevierStylePara elsevierViewall">The Osteoporosis Assessment Questionnaire (OPAQ) is a self-reported instrument that assesses quality of life in postmenopausal women with osteoporosis and fractures (<a class="elsevierStyleCrossRef" href="#bib30">30</a>), and it was recently used by our group to analyze the quality of life after a balance training program in women with senile osteoporosis (<a class="elsevierStyleCrossRef" href="#bib31">31</a>),(<a class="elsevierStyleCrossRef" href="#bib32">32</a>). The OPAQ comprises five questions that assess overall well-being and another 79 questions that are grouped into 18 domains. These domains are distributed into four dimensions (<a class="elsevierStyleCrossRef" href="#bib33">33</a>): physical function, psychological status, symptoms, and social interaction. Cantarelli (<a class="elsevierStyleCrossRef" href="#bib34">34</a>) adapted and validated this questionnaire for use in Brazil (in Brazilian Portuguese) and demonstrated that the OPAQ is a valid and reproducible instrument to evaluate osteoporosis patients. Because the OPAQ comprises a large number of questions and requires 30-40 min to complete, revised versions of the questionnaire have been developed, namely the Osteoporosis Assessment Questionnaire 2 (OPAQ2) and the Osteoporosis Assessment Questionnaire Short Version (OPAQ SV).</p></span><span id="cesec100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle110">Osteoporosis Assessment Questionnaire 2</span><p id="para200" class="elsevierStylePara elsevierViewall">The OPAQ2 comprises 67 items grouped into 14 health scales (<a class="elsevierStyleCrossRef" href="#bib26">26</a>). The OPAQ2 is a self-reported questionnaire that has been tested in elderly populations (<a class="elsevierStyleCrossRef" href="#bib35">35</a>), and it requires 20-30 min to complete.</p></span><span id="cesec110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle120">Osteoporosis Assessment Questionnaire Short Version</span><p id="para210" class="elsevierStylePara elsevierViewall">The OPAQ SV consists of 34 items organized into three dimensions: physical function, emotional status, and symptoms (<a class="elsevierStyleCrossRef" href="#bib36">36</a>). The OPAQ SV does not collect data related to the patient’s daily activities or social status (<a class="elsevierStyleCrossRef" href="#bib37">37</a>).</p></span><span id="cesec120" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle130">Osteoporosis Functional Disability Questionnaire</span><p id="para220" class="elsevierStylePara elsevierViewall">The Osteoporosis Functional Disability Questionnaire (OFDQ) (<a class="elsevierStyleCrossRef" href="#bib38">38</a>) was developed to assess functional disabilities in osteoporosis patients who experienced vertebral compression and lower back pain caused by vertebral fractures. The OFDQ has been evaluated in clinical trials involving exercise programs (<a class="elsevierStyleCrossRef" href="#bib38">38</a>) and proved sensitive for detecting improvements in the activities of daily living among the patients in rehabilitation programs. The OFDQ is a self-reported questionnaire that requires approximately 25 min to complete. The questionnaire comprises 59 items grouped into five domains: pain, depression, functional status, social activities, and confidence in the treatment proposed. The OFDQ has proven useful in assessing clinical severity and exhibits a reliable correlation with spinal injury caused by osteoporosis (<a class="elsevierStyleCrossRef" href="#bib8">8</a>),(<a class="elsevierStyleCrossRef" href="#bib33">33</a>),(<a class="elsevierStyleCrossRef" href="#bib38">38</a>).</p></span><span id="cesec130" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle140">Quality of Life Questionnaire of the European Foundation for Osteoporosis</span><p id="para230" class="elsevierStylePara elsevierViewall">The Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO) originally comprised 48 questions, including six visual analogue scales (<a class="elsevierStyleCrossRef" href="#bib39">39</a>). The QUALEFFO is specific to patients with vertebral fractures and comprises five domains: pain, physical function, social function, general health perception, and mental function (<a class="elsevierStyleCrossRef" href="#bib8">8</a>),(<a class="elsevierStyleCrossRef" href="#bib40">40</a>). The questionnaire has been used in prevention and treatment protocols, and it has proven to be reproducible and coherent. After the QUALEFFO had been validated, two summarized versions of it were developed.</p></span><span id="cesec140" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle150">41-item Quality of Life Questionnaire of the European Foundation for Osteoporosis</span><p id="para240" class="elsevierStylePara elsevierViewall">The 41-item Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO-41) was developed to measure the quality of life in patients with vertebral deformities (<a class="elsevierStyleCrossRef" href="#bib41">41</a>). The QUALEFFO-41 consists of 41 questions grouped into five domains: pain, physical function, social function, general health perception, and mental function (<a class="elsevierStyleCrossRef" href="#bib8">8</a>),(<a class="elsevierStyleCrossRef" href="#bib39">39</a>).</p></span><span id="cesec150" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle160">31-item Quality of Life Questionnaire of the European Foundation for Osteoporosis</span><p id="para250" class="elsevierStylePara elsevierViewall">The 31-item Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO-31) was developed as a shortened version of the QUALEFFO-41 (<a class="elsevierStyleCrossRef" href="#bib41">41</a>). The QUALEFFO-31, which consists of three domains (pain, physical function, and mental state), excludes the most redundant questions of the QUALEFFO-41 and improves its conceptual structure.</p></span><span id="cesec160" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle170">Osteoporosis-targeted quality of life</span><p id="para260" class="elsevierStylePara elsevierViewall">The Osteoporosis-Targeted Quality of Life (OPTQoL) questionnaire is used in epidemiological studies assessing the quality of life of elderly women with or without clinical osteoporosis (<a class="elsevierStyleCrossRef" href="#bib39">39</a>). The OPTQoL questionnaire is a reliable instrument that comprises 26 scored questions that are distributed in three domains (physical activity, adaptations for activities of daily living, and fears) and six additional questions regarding the clinical and diagnostic alterations of osteoporosis (<a class="elsevierStyleCrossRef" href="#bib5">5</a>),(<a class="elsevierStyleCrossRef" href="#bib8">8</a>),(<a class="elsevierStyleCrossRef" href="#bib42">42</a>).</p></span><span id="cesec170" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle180">Japanese Osteoporosis Quality of Life Questionnaire</span><p id="para270" class="elsevierStylePara elsevierViewall">The Japanese Osteoporosis Quality of Life Questionnaire (JOQOL) was based on the OPAQ and QUALEFFO-41 and adapted to the lifestyle of the Japanese people (<a class="elsevierStyleCrossRef" href="#bib43">43</a>). The JOQOL comprises 38 items that are grouped into six domains: pain, activities of daily living, social activity and leisure, general health, postural awareness, psychological factors, and falls (<a class="elsevierStyleCrossRef" href="#bib44">44</a>).</p></span><span id="cesec180" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle190">16-item Assessment of Health-Related Quality of Life in Osteoporosis</span><p id="para280" class="elsevierStylePara elsevierViewall">The 16-item Assessment of Health-Related Quality of Life in Osteoporosis (ECOS-16) is a short questionnaire that is rapidly applied and easily administered (<a class="elsevierStyleCrossRef" href="#bib45">45</a>). The ECOS-16 comprises 16 questions, four of which are from the OQLQ, and 12 of which are from the QUALEFFO. These 16 questions are grouped into four categories: physical function, disease-related fear, psychosocial status, and pain. The ECOS-16 is a self-reported questionnaire with satisfactory preliminary psychometric properties. The questionnaire appears to be a promising tool for use in research and clinical practice when evaluating postmenopausal women with osteoporosis with or without vertebral fractures (<a class="elsevierStyleCrossRef" href="#bib46">46</a>).</p></span><span id="cesec190" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle200">Quality of Life Questionnaire in Osteoporosis</span><p id="para290" class="elsevierStylePara elsevierViewall">The Quality of Life Questionnaire in Osteoporosis (QUALIOSTTM) was developed in 2001 (<a class="elsevierStyleCrossRef" href="#bib47">47</a>). The QUALIOST is a specific instrument that is used in conjunction with the generic Medical Outcomes Study 36-item Short-Form Health Survey because the QUALIOST includes domains that are not addressed by the latter instrument (fear of the future, self-image, well-being, mobility, localized pain, and specific mental repercussions). The QUALIOST is a self-reported questionnaire comprising 23 questions that are distributed into two dimensions: physical and emotional. The questionnaire can be used in therapeutic trials to assess the impact of vertebral fractures on the quality of life of women with postmenopausal osteoporosis.</p></span></span><span id="cesec200" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle210">DISCUSSION</span><span id="cesec210" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle220">Indications of osteoporosis-targeted quality-of-life questionnaires</span><span id="cesec220" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle230">Perimenopause</span><p id="para300" class="elsevierStylePara elsevierViewall">The WHQ should be used to evaluate women in perimenopause because it addresses the specific characteristics of this population. A disadvantage of the WHQ is that it does not address the feelings that result from social interactions and is restricted to evaluating how women perceive the perimenopause-related alterations in their bodies (<a class="elsevierStyleCrossRef" href="#bib48">48</a>).</p></span><span id="cesec230" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle240">Fractures: comparisons of specific questionnaires</span><p id="para310" class="elsevierStylePara elsevierViewall">The most extensively tested questionnaires regarding vertebral fractures are the OQLQ (interviewer-administered) and the QUALEFFO (self-report). The OQLQ has been tested in patients with osteoporosis and fractures associated with chronic lower back pain. The QUALEFFO has been tested in patients with osteoporosis and fractures with or without chronic lower back pain. These two questionnaires were developed as instruments to be used in evaluating the outcomes of clinical trials. The OQLQ and the QUALEFFO were compared in a study assessing the quality of life in women with osteoporosis with vertebral fractures (<a class="elsevierStyleCrossRef" href="#bib49">49</a>). The authors found that the performance of the OQLQ was superior to that of the QUALEFFO. This evaluation was in part attributed to the fact that the QUALEFFO is a self-reported questionnaire. The studied population took longer to complete the QUALEFFO, and a greater number of questions were left unanswered on the QUALEFFO than on the OQLQ. In addition, it was observed that the degree of difficulty in completing the QUALEFFO was inversely proportional to the patient’s level of education. Furthermore, the psychometric properties of the OQLQ were found to be significantly superior to those of the QUALEFFO when evaluating women with one or more vertebral fractures, a result that was also reported by other authors (<a class="elsevierStyleCrossRef" href="#bib49">49</a>),(<a class="elsevierStyleCrossRef" href="#bib50">50</a>).</p><p id="para320" class="elsevierStylePara elsevierViewall">In its original form, the OPAQ was largely unsuccessful within the scientific community for clinical practice and research purposes because it was quite extensive and time-consuming. Therefore, shorter versions of this questionnaire were developed: the OPAQ2 (<a class="elsevierStyleCrossRef" href="#bib26">26</a>) and the OPAQ SV (<a class="elsevierStyleCrossRef" href="#bib36">36</a>). The OPAQ2 was initially used to evaluate hip fracture cases (<a class="elsevierStyleCrossRef" href="#bib35">35</a>).</p></span><span id="cesec240" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle250">Mode of administration: self-reported or interviewer-administered?</span><p id="para330" class="elsevierStylePara elsevierViewall">In clinical practice, self-reported questionnaires are an excellent option because patients can complete such questionnaires in the waiting room. However, this procedure depends on the patient’s level of education.</p></span><span id="cesec250" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle260">Time required for questionnaire administration</span><p id="para340" class="elsevierStylePara elsevierViewall">The time required to complete a questionnaire is dependent on the behavior of the patient and the physician. Short questionnaires can be easily completed by the patient in a short period of time, thus increasing the patient’s willingness to do so. The mini-OQLQ, for instance, requires 2-3 min to complete (<a class="elsevierStyleCrossRef" href="#bib29">29</a>). The mini-OQLQ is considered a sensitive instrument for evaluating patients with osteoporosis, vertebral fractures and pain, (<a class="elsevierStyleCrossRef" href="#bib51">51</a>) as well as postmenopausal women with osteoporosis and vertebral fractures (<a class="elsevierStyleCrossRef" href="#bib52">52</a>). However, one study demonstrated that the mini-OQLQ score exhibits a weak correlation with the clinical severity of the disease (<a class="elsevierStyleCrossRef" href="#bib11">11</a>). Another short questionnaire is the ECOS-16. The ECOS-16 comprises 16 questions, has adequate preliminary psychometric properties and seems promising for use in research and clinical practice when evaluating women with postmenopausal osteoporosis with or without vertebral fractures.</p></span><span id="cesec260" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle270">Focus on patient adaptations</span><p id="para350" class="elsevierStylePara elsevierViewall">If the assessment focuses on disability, the need for patients to make adaptations to perform daily living activities and related patient concerns, the OPTQoL questionnaire should be used.</p></span><span id="cesec270" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle280">Effects of exercise on quality of life using osteoporosis-specific questionnaires</span><p id="para360" class="elsevierStylePara elsevierViewall">Only three studies have used specific questionnaires to assess the effect of exercise on quality of life (<a class="elsevierStyleCrossRef" href="#bib35">35</a>),(<a class="elsevierStyleCrossRef" href="#bib51">51</a>),(<a class="elsevierStyleCrossRef" href="#bib52">52</a>).</p><p id="para370" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="celist10"><li class="elsevierStyleListItem" id="celistitem10"><span class="elsevierStyleLabel">1)</span><p id="para380" class="elsevierStylePara elsevierViewall">The first study assessed quality of life after patients engaged in an exercise program (<a class="elsevierStyleCrossRef" href="#bib37">37</a>). The authors of the study developed the OFDQ to determine whether disability and back pain caused by vertebral fractures correlated significantly with the disease. By applying the OFDQ, the authors were able to detect significant improvements in the performance of daily living activities and social interactions as well as reduced pain in patients who performed aerobic exercises. However, osteoporosis patients who were sedentary exhibited increased pain and reduced abilities to perform activities of daily living (<a class="elsevierStyleCrossRef" href="#bib37">37</a>). It would be interesting to apply the OFDQ in studies assessing the effect of exercise on disability. However, this effect was not described by the authors who developed the OFDQ, making it impossible for the scientific community to use the questionnaire for that purpose.</p></li><li class="elsevierStyleListItem" id="celistitem20"><span class="elsevierStyleLabel">2)</span><p id="para390" class="elsevierStylePara elsevierViewall">The second study used the OQLQ to assess the efficacy of a six-month in-home exercise program (stretching, strength training and walking) in fragile elderly women with vertebral fractures (<a class="elsevierStyleCrossRef" href="#bib53">53</a>). The authors observed an improvement in quality of life in terms of the symptoms, emotional aspect, leisure and social activity, as well as a reduction in fatigue and pain when walking.</p></li><li class="elsevierStyleListItem" id="celistitem30"><span class="elsevierStyleLabel">3)</span><p id="para400" class="elsevierStylePara elsevierViewall">The third study demonstrated the reproducibility of the QUALEFFO (<a class="elsevierStyleCrossRef" href="#bib54">54</a>). By administering this questionnaire, the authors observed that resistance training and agility training significantly improved the quality of life, social interaction, physical ability and back pain of elderly women with osteopenia or osteoporosis.</p></li><li class="elsevierStyleListItem" id="celistitem40"><span class="elsevierStyleLabel">4)</span><p id="para410" class="elsevierStylePara elsevierViewall">The fourth study, conducted by our group, demonstrated that over a 12-month period, the Balance Training Program reduces falls and improves functional balance (<a class="elsevierStyleCrossRef" href="#bib31">31</a>) and quality of life (<a class="elsevierStyleCrossRef" href="#bib32">32</a>). The quality of life was evaluated before and at the end of the trial using the Osteoporosis Assessment Questionnaire (OPAQ) and demonstrated an improvement in the followings domains: well-being, physical function, psychological status, symptoms and social interactions (<a class="elsevierStyleCrossRef" href="#bib32">32</a>).</p></li></ul></p><p id="para420" class="elsevierStylePara elsevierViewall">Assessing quality of life is essential to health research and clinical trials involving osteoporosis. The choice of the instrument used to assess quality of life depends on the type of research and on the research question asked; each instrument has specific advantages and disadvantages (<a class="elsevierStyleCrossRef" href="#bib8">8</a>). Furthermore, it is important that these instruments be available in the patient’s native language because a specific methodology has been established to validate their use (<a class="elsevierStyleCrossRef" href="#bib2">2</a>),(<a class="elsevierStyleCrossRef" href="#bib55">55</a>),(<a class="elsevierStyleCrossRef" href="#bib56">56</a>).</p><p id="para430" class="elsevierStylePara elsevierViewall">Most quality of life osteoporosis questionnaires have been developed in the English language (<a class="elsevierStyleCrossRef" href="#bib33">33</a>),(<a class="elsevierStyleCrossRef" href="#bib42">42</a>),(<a class="elsevierStyleCrossRef" href="#bib28">28</a>). Thus, for these instruments to be used in international studies and in clinical practice, it is necessary that these instruments address the same concepts in all languages to make it possible to pool data and compare results across countries. In fact, these nine questionnaires should be validated and proven reliable before being used.</p><p id="para440" class="elsevierStylePara elsevierViewall">Indeed, many questionnaires have already been validated for use in other countries and/or cultures (<a class="elsevierStyleCrossRef" href="#bib57">57</a>)-(<a class="elsevierStyleCrossRef" href="#bib61">61</a>). The QUALEFFO (<a class="elsevierStyleCrossRef" href="#bib39">39</a>) is the quality of life osteoporosis instrument most validated in other countries, including the following languages: Serbian (<a class="elsevierStyleCrossRef" href="#bib7">7</a>), Turkish (<a class="elsevierStyleCrossRef" href="#bib58">58</a>), Chinese (<a class="elsevierStyleCrossRef" href="#bib59">59</a>), Spanish (<a class="elsevierStyleCrossRef" href="#bib60">60</a>), and Italian (<a class="elsevierStyleCrossRef" href="#bib61">61</a>). Only the OPAQ instrument has been validated in Portuguese (<a class="elsevierStyleCrossRef" href="#bib34">34</a>).</p><p id="para450" class="elsevierStylePara elsevierViewall">Measuring health-related quality of life has become an important issue in health service research and in clinical trials involving osteoporosis. Nine specific questionnaires related to osteoporosis (OP) quality of life are available in the literature. The choice of a particular questionnaire (WHQ, OQLQ, OPAQ, OFDQ, QUALEFFO, OPTQOL, JOQOL, ECOS-16, and QUALIOSTTM) will depend on the type of research and the major question being asked because each instrument may have particular advantages. It is important that all of these OP-specific questionnaires be validated in the language of the country of origin before being used in clinical research and clinical practice.</p><p id="para460" class="elsevierStylePara elsevierViewall">Key points:</p><p id="para470" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="celist20"><li class="elsevierStyleListItem" id="celistitem50"><span class="elsevierStyleLabel">•</span><p id="para480" class="elsevierStylePara elsevierViewall">Nine specific questionnaires related to osteoporosis (OP) quality of life are available in the literature.</p></li><li class="elsevierStyleListItem" id="celistitem60"><span class="elsevierStyleLabel">•</span><p id="para490" class="elsevierStylePara elsevierViewall">QUALEFO is the OP-specific questionnaire most commonly used in the literature.</p></li><li class="elsevierStyleListItem" id="celistitem70"><span class="elsevierStyleLabel">•</span><p id="para500" class="elsevierStylePara elsevierViewall">QUALEFFO and OQLQ are targeted more toward fracture assessments.</p></li><li class="elsevierStyleListItem" id="celistitem80"><span class="elsevierStyleLabel">•</span><p id="para510" class="elsevierStylePara elsevierViewall">OFDQ is used in longitudinal studies involving exercise.</p></li><li class="elsevierStyleListItem" id="celistitem90"><span class="elsevierStyleLabel">•</span><p id="para520" class="elsevierStylePara elsevierViewall">Osteoporosis-specific quality of life questionnaires should be validated in the language of the country of origin before being used.</p></li></ul></p></span></span></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:6 [ 0 => array:2 [ "identificador" => "xpalclavsec1582085" "titulo" => "KEYWORDS" ] 1 => array:3 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "cesec20" "titulo" => "Defining quality of life" ] 1 => array:2 [ "identificador" => "cesec30" "titulo" => "Quality of life and osteoporosis" ] ] ] 2 => array:3 [ "identificador" => "cesec40" "titulo" => "MATERIALS AND METHODS" "secciones" => array:15 [ 0 => array:2 [ "identificador" => "cesec50" "titulo" => "Specific instruments" ] 1 => array:2 [ "identificador" => "cesec60" "titulo" => "Women's Health Questionnaire" ] 2 => array:2 [ "identificador" => "cesec70" "titulo" => "Osteoporosis Quality of Life Questionnaire" ] 3 => array:2 [ "identificador" => "cesec80" "titulo" => "Mini-Osteoporosis Quality of Life Questionnaire" ] 4 => array:2 [ "identificador" => "cesec90" "titulo" => "Osteoporosis Assessment Questionnaire" ] 5 => array:2 [ "identificador" => "cesec100" "titulo" => "Osteoporosis Assessment Questionnaire 2" ] 6 => array:2 [ "identificador" => "cesec110" "titulo" => "Osteoporosis Assessment Questionnaire Short Version" ] 7 => array:2 [ "identificador" => "cesec120" "titulo" => "Osteoporosis Functional Disability Questionnaire" ] 8 => array:2 [ "identificador" => "cesec130" "titulo" => "Quality of Life Questionnaire of the European Foundation for Osteoporosis" ] 9 => array:2 [ "identificador" => "cesec140" "titulo" => "41-item Quality of Life Questionnaire of the European Foundation for Osteoporosis" ] 10 => array:2 [ "identificador" => "cesec150" "titulo" => "31-item Quality of Life Questionnaire of the European Foundation for Osteoporosis" ] 11 => array:2 [ "identificador" => "cesec160" "titulo" => "Osteoporosis-targeted quality of life" ] 12 => array:2 [ "identificador" => "cesec170" "titulo" => "Japanese Osteoporosis Quality of Life Questionnaire" ] 13 => array:2 [ "identificador" => "cesec180" "titulo" => "16-item Assessment of Health-Related Quality of Life in Osteoporosis" ] 14 => array:2 [ "identificador" => "cesec190" "titulo" => "Quality of Life Questionnaire in Osteoporosis" ] ] ] 3 => array:3 [ "identificador" => "cesec200" "titulo" => "DISCUSSION" "secciones" => array:1 [ 0 => array:3 [ "identificador" => "cesec210" "titulo" => "Indications of osteoporosis-targeted quality-of-life questionnaires" "secciones" => array:6 [ 0 => array:2 [ "identificador" => "cesec220" "titulo" => "Perimenopause" ] 1 => array:2 [ "identificador" => "cesec230" "titulo" => "Fractures: comparisons of specific questionnaires" ] 2 => array:2 [ "identificador" => "cesec240" "titulo" => "Mode of administration: self-reported or interviewer-administered?" ] 3 => array:2 [ "identificador" => "cesec250" "titulo" => "Time required for questionnaire administration" ] 4 => array:2 [ "identificador" => "cesec260" "titulo" => "Focus on patient adaptations" ] 5 => array:2 [ "identificador" => "cesec270" "titulo" => "Effects of exercise on quality of life using osteoporosis-specific questionnaires" ] ] ] ] ] 4 => array:2 [ "identificador" => "xack639154" "titulo" => "ACKNOWLEDGMENTS" ] 5 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2012-05-17" "fechaAceptado" => "2012-07-10" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1582085" "palabras" => array:6 [ 0 => "Quality of Life" 1 => "Osteoporosis" 2 => "Questionnaires" 3 => "QUALEFFO" 4 => "OQLQ" 5 => "OPAQ" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:1 [ "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><p id="spara10" class="elsevierStyleSimplePara elsevierViewall">To review all specific questionnaires regarding quality of life in osteoporosis and to describe their distinctive indications, we searched Medline, the Scientific Electronic Library Online database, and the Latin-American and Caribbean Health Sciences Literature database. Nine specific questionnaires related to osteoporosis quality of life were found: 1) the Women’s Health Questionnaire, 2) Osteoporosis Quality of Life Questionnaire, 3) Osteoporosis Assessment Questionnaire, 4) Osteoporosis Functional Disability Questionnaire, 5) Quality of Life Questionnaire of the European Foundation for Osteoporosis, 6) Osteoporosis-Targeted Quality of Life Questionnaire, 7) Japanese Osteoporosis Quality of Life Questionnaire, 8) the 16-item Assessment of Health-Related Quality of Life in Osteoporosis, and 9) the Quality of Life Questionnaire in Osteoporosis (QUALIOST<span class="elsevierStyleSup">TM</span>). The Quality of Life Questionnaire of the European Foundation for Osteoporosis is the osteoporosis-specific questionnaire most commonly used in the literature. The Quality of Life Questionnaire of the European Foundation for Osteoporosis and the Osteoporosis Quality of Life Questionnaire are targeted more toward fracture assessment, and the Osteoporosis Functional Disability Questionnaire can be used for longitudinal studies involving exercise. In the present study, the authors summarize all of the specific questionnaires for osteoporosis and demonstrate that these questionnaires should be selected based on the objectives to be evaluated. Osteoporosis-specific quality of life questionnaires should be validated in the language of the country of origin before being used.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara" id="cenpara10">No potential conflict of interest was reported.</p> <p class="elsevierStyleNotepara" id="cenpara20">Pereira RM and Madureira MM were responsible for the study concept and design. Madureira MM and Pereira RM conducted the analysis and interpretation of the data. Madureira MM, Ciconelli R, and Pereira RM prepared and revised the manuscript.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:61 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "World Health Organization Quality of Life (WHOQOL)" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "WWW" => array:2 [ "link" => "http://www.who.int/substance_abuse/research_tools/whoqolbref/en/" "fecha" => "2009" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tradução para a língua portuguesa e validação do questionário genérico de avaliação de qualidade de vida SF-36 (Brasil SF-36)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ RM Ciconelli \n \t\t\t\t\t\t\t\t """ 1 => """ MB Ferraz \n \t\t\t\t\t\t\t\t """ 2 => """ W Santos \n \t\t\t\t\t\t\t\t """ 3 => """ I Meinão \n \t\t\t\t\t\t\t\t """ 4 => """ MR Quaresma \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Bras Reumat" "fecha" => "1999" "volumen" => "39" "numero" => "3" "paginaInicial" => "50" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Individual-patient monitoring in clinical practice: are available health status surveys adequate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ CA Mc Horney \n \t\t\t\t\t\t\t\t """ 1 => """ AR Tarlov \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Qual Life Res" "fecha" => "1995" "volumen" => "4" "numero" => "4" "paginaInicial" => "307" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patient-reported outcomes: the example of health-related quality of life – a European guidance domunet for the improved integration of health-related quality of life assessment in the drug regulatory process" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ O Chassany \n \t\t\t\t\t\t\t\t """ 1 => """ P Sagnier \n \t\t\t\t\t\t\t\t """ 2 => """ P Marquis \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Drug Inf J" "fecha" => "2002" "volumen" => "36" "numero" => "1" "paginaInicial" => "38" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quality of life in patients with osteoporosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ P Lips \n \t\t\t\t\t\t\t\t """ 1 => """ M Natasja \n \t\t\t\t\t\t\t\t """ 2 => """ V Schoor \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Osteoporos Int" "fecha" => "2005" "volumen" => "16" "numero" => "5" "paginaInicial" => "55" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A review of economic evaluation in osteoporosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ A Cranney \n \t\t\t\t\t\t\t\t """ 1 => """ D Coyle \n \t\t\t\t\t\t\t\t """ 2 => """ V Welch \n \t\t\t\t\t\t\t\t """ 3 => """ KM Lee \n \t\t\t\t\t\t\t\t """ 4 => """ P Tugwell \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arthritis Care Res" "fecha" => "1999" "volumen" => "12" "numero" => "6" "paginaInicial" => "34" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quality of life measures in health care II. 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Neither CNPq nor CAPES played any part in the completion of the review or in this paper.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/18075932/0000006700000011/v1_202212011245/S1807593222022037/v1_202212011245/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/18075932/0000006700000011/v1_202212011245/S1807593222022037/v1_202212011245/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222022037?idApp=UINPBA00004N" ]
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