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array:24 [ "pii" => "S1807593222023316" "issn" => "18075932" "doi" => "10.1590/S1807-59322011001000012" "estado" => "S300" "fechaPublicacion" => "2011-10-01" "aid" => "2331" "copyright" => "CLINICS" "copyrightAnyo" => "2011" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "fla" "cita" => "Clinics. 2011;66:1743-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S1807593222023328" "issn" => "18075932" "doi" => "10.1590/S1807-59322011001000013" "estado" => "S300" "fechaPublicacion" => "2011-10-01" "aid" => "2332" "copyright" => "CLINICS" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "fla" "cita" => "Clinics. 2011;66:1747-55" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">CLINICAL SCIENCE</span>" "titulo" => "Correlation of <span class="elsevierStyleItalic">MGMT</span> promoter methylation status with gene and protein expression levels in glioblastoma" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1747" "paginaFinal" => "1755" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 768 "Ancho" => 478 "Tamanyo" => 14286 ] ] "descripcion" => array:1 [ "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Correlation between relative gene expression level of <span class="elsevierStyleItalic">MGMT</span> and promoter methylation status determined using MSP (A) and PyroS (B). <span class="elsevierStyleItalic">MGMT</span> expression levels in the GBM samples were determined relative to non-neoplastic tissues. The horizontal bars show the median values for the relative expression of <span class="elsevierStyleItalic">MGMT</span> in each group. The Mann-Whitney test was used to evaluate the differences in the relative expression level between the methylated and unmethylated groups.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Miyuki Uno, Sueli Mieko Oba-Shinjo, Anamaria Aranha Camargo, Ricardo Pereira Moura, Paulo Henrique de Aguiar, Hector Navarro Cabrera, Marcos Begnami, Sérgio Rosemberg, Manoel Jacobsen Teixeira, Suely Kazue Nagahashi Marie" "autores" => array:10 [ 0 => array:2 [ "nombre" => "Miyuki" "apellidos" => "Uno" ] 1 => array:2 [ "nombre" => "Sueli Mieko" "apellidos" => "Oba-Shinjo" ] 2 => array:2 [ "nombre" => "Anamaria Aranha" "apellidos" => "Camargo" ] 3 => array:2 [ "nombre" => "Ricardo Pereira" "apellidos" => "Moura" ] 4 => array:2 [ "nombre" => "Paulo Henrique" "apellidos" => "de Aguiar" ] 5 => array:2 [ "nombre" => "Hector Navarro" "apellidos" => "Cabrera" ] 6 => array:2 [ "nombre" => "Marcos" "apellidos" => "Begnami" ] 7 => array:2 [ "nombre" => "Sérgio" "apellidos" => "Rosemberg" ] 8 => array:2 [ "nombre" => "Manoel Jacobsen" "apellidos" => "Teixeira" ] 9 => array:2 [ "nombre" => "Suely Kazue Nagahashi" "apellidos" => "Marie" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222023328?idApp=UINPBA00004N" "url" => "/18075932/0000006600000010/v1_202212011334/S1807593222023328/v1_202212011334/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1807593222023304" "issn" => "18075932" "doi" => "10.1590/S1807-59322011001000011" "estado" => "S300" "fechaPublicacion" => "2011-10-01" "aid" => "2330" "copyright" => "CLINICS" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "fla" "cita" => "Clinics. 2011;66:1735-42" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">CLINICAL SCIENCE</span>" "titulo" => "Comparative study of earthquake-related and non-earthquake-related head traumas using multidetector computed tomography" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1735" "paginaFinal" => "1742" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig3" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 904 "Ancho" => 416 "Tamanyo" => 51886 ] ] "descripcion" => array:1 [ "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">(A) A 26-year-old man with earthquake-related head trauma caused by a collapsed building in the Sichuan earthquake. The volume-rendering image shows fractures involving the right orbit, zygomata and maxilla. (B) A 40-year-old man with head trauma caused by a traffic accident. The volume-rendering image shows multiple fractures involving the bilateral orbits, zygomata, nasal bone, left maxilla and mandible, and the bilateral maxillas are detached.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Zhi-gang Chu, Zhi-gang Yang, Zhi-hui Dong, Tian-wu Chen, Zhi-yu Zhu, Heng Shao" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Zhi-gang" "apellidos" => "Chu" ] 1 => array:2 [ "nombre" => "Zhi-gang" "apellidos" => "Yang" ] 2 => array:2 [ "nombre" => "Zhi-hui" "apellidos" => "Dong" ] 3 => array:2 [ "nombre" => "Tian-wu" "apellidos" => "Chen" ] 4 => array:2 [ "nombre" => "Zhi-yu" "apellidos" => "Zhu" ] 5 => array:2 [ "nombre" => "Heng" "apellidos" => "Shao" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222023304?idApp=UINPBA00004N" "url" => "/18075932/0000006600000010/v1_202212011334/S1807593222023304/v1_202212011334/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">CLINICAL SCIENCE</span>" "titulo" => "The search for stability: bar displacement in three series of <span class="elsevierStyleItalic">pectus excavatum</span> patients treated with the Nuss technique" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1743" "paginaFinal" => "1746" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Miguel Lia Tedde, José Ribas Milanez de Campos, João-Carlos Das-Neves-Pereira, Fernando Conrado Abrão, Fábio Biscegli Jatene" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Miguel Lia" "apellidos" => "Tedde" "email" => array:1 [ 0 => "tedde@usp.br" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "José Ribas Milanez" "apellidos" => "de Campos" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">II</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "João-Carlos" "apellidos" => "Das-Neves-Pereira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">III</span>" "identificador" => "aff3" ] ] ] 3 => array:3 [ "nombre" => "Fernando Conrado" "apellidos" => "Abrão" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "Fábio Biscegli" "apellidos" => "Jatene" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Department of Thoracic Surgery, Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo/SP, Brazil." "etiqueta" => "I" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Hospital Israelita Albert Einstein, São Paulo/SP, Brazil." "etiqueta" => "II" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Hôpital Européen Georges Pompidou - Chirurgie Thoracique/ Paris/FR." "etiqueta" => "III" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Tel.: 55 11 2661-5708" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 332 "Ancho" => 498 "Tamanyo" => 17480 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">A and B: Examples of bar displacement.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle60">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Pectus excavatum</span> (PE) is the most common pediatric congenital anomaly of the chest wall and is observed mostly in male patients.<a class="elsevierStyleCrossRefs" href="#bib1">1,2</a> The systemic effects of the deformity range from otherwise asymptomatic presentation to exercise intolerance that necessitates surgical treatment.<a class="elsevierStyleCrossRef" href="#bib3">3</a> The surgical treatment options include chondrosternal resection, sternal osteotomy and elevation, sternal turnover, and other modifications introduced since the late 1950s.</p><p id="para20" class="elsevierStylePara elsevierViewall">A minimally invasive operation using a <span class="elsevierStyleItalic">pectus</span> bar with interesting results was described by Nuss et al.<a class="elsevierStyleCrossRef" href="#bib4">4</a> This procedure improves the anatomic, aesthetic, and functional results without an unaesthetic anterior chest wall incision. However, early and late complications of the Nuss method have been reported in the literature, including pneumothorax, pleural effusion, pain, pericardial effusion, cardiac perforation, wound infection, and bar displacement.<a class="elsevierStyleCrossRef" href="#bib2">2</a></p><p id="para30" class="elsevierStylePara elsevierViewall">Bar displacement is a serious complication that can occur anytime, but occurs most frequently in the 30 days following the minimally invasive repair of PE.<a class="elsevierStyleCrossRef" href="#bib4">4</a> Following the initial acceptance and widespread use of the Nuss procedure, the rate of bar displacement was high. However, since the initial development of the technique, several modifications have been proposed in an effort to make the technique both safer and more effective. These modifications include the introduction and development of new positioning, fixation techniques, and stabilizers to replace pericostal sutures or other methods used to prevent bar displacement (<a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a>).<a class="elsevierStyleCrossRef" href="#bib5">5</a></p><elsevierMultimedia ident="fig1"></elsevierMultimedia><p id="para40" class="elsevierStylePara elsevierViewall">The objective of this paper is to present our experience and compare bar displacement rates before and after the introduction of new methods, including using a shorter bar, a new model and a more medial positioning of the stabilizers throughout the execution of the Nuss procedure.</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">PATIENTS AND METHODS</span><p id="para50" class="elsevierStylePara elsevierViewall">After Ethics Committee approval, we retrospectively reviewed the patient data of 122 patients (109 males and 13 females) with a mean age of 17±3 (range 5 to 37) years that had undergone <span class="elsevierStyleItalic">pectus excavatum</span> repair utilizing the Nuss procedure between May 2003 and June 2010. All data related to the hospital stay and follow-up results from 1 to 83 months post-operation were reviewed. During the study period, we used the basic Nuss technique with two technical modifications. For this purposes of this study, the patients who were treated with the modified techniques were divided into two additional series, for an overall total of three patient series.</p><p id="para60" class="elsevierStylePara elsevierViewall">In the first series, which included the first 24 patients, we fixed the bar and stabilizers in a manner similar to the original Nuss procedure.<a class="elsevierStyleCrossRef" href="#bib6">6</a></p><p id="para70" class="elsevierStylePara elsevierViewall">In the second series, which included patients 25–71, we added the technical modification proposed by Hebra et al.<a class="elsevierStyleCrossRef" href="#bib3">3</a> in an effort to reduce the bar displacement rate. This modification, referred to as “third point fixation,” involves placing a suture around the bar and the underlying ribs.</p><p id="para80" class="elsevierStylePara elsevierViewall">Finally, our third series, which is a group of 51 patients (post-2008), underwent the Nuss procedure with additional technical modifications, including a smaller bar size and the use of a newly designed stabilizer model. This new model, with central grooves on the posterior surface, allows improved sliding of the stabilizer over the bar, regardless of its curvature. This ensures a more medial positioning of the stabilizer (<a class="elsevierStyleCrossRef" href="#fig2">Figure 2</a>).<a class="elsevierStyleCrossRef" href="#bib5">5</a></p><elsevierMultimedia ident="fig2"></elsevierMultimedia><p id="para90" class="elsevierStylePara elsevierViewall">Three patients were referred to us 7, 8, and 11 years post unsuccessful treatment with a modified Ravitch technique. Two of these patients were included in the second series, and one patient was included in the third.</p><p id="para100" class="elsevierStylePara elsevierViewall">Chest X-rays were taken postoperatively in all patients to both document the results and enable comparison of the position of the bar throughout the follow-up period. As no movement of the bar is expected, any position different from the initial location visualized in the X-rays was classified as bar displacement.</p><p id="para110" class="elsevierStylePara elsevierViewall">Postoperative pain management was achieved using epidural catheters and non-steroidal anti-inflammatory drugs. The follow-up protocol included outpatient visits at three weeks, three months, six months and annually for three years. Light physical activity was allowed three weeks after surgery, all kinds of sports except contact sports were allowed after three months, and all activity was allowed after six months. The bar was removed after the three-year follow-up period.</p><p id="para120" class="elsevierStylePara elsevierViewall">Complications were classified as “major” if an organ injury occurred or if a secondary intervention became necessary or as “minor” if there was any need for clinical treatment and/or if evacuation of fluid or air from the thorax by drainage became necessary.</p><p id="para130" class="elsevierStylePara elsevierViewall">The data is presented as the frequency and percentage. To compare the incidence of complications in each of the series we used the Likelihood Ratio test. A <span class="elsevierStyleItalic">p-</span>value less than 0.05 was considered significant. All statistical analyses were performed using SPSS Version 13 software (SPSS, Chicago, IL, USA).</p></span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">RESULTS</span><p id="para140" class="elsevierStylePara elsevierViewall">There were no deaths in any of the series. The observed complications are listed in <a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>.</p><elsevierMultimedia ident="tbl1"></elsevierMultimedia><p id="para150" class="elsevierStylePara elsevierViewall">Minor complications occurred in six (4.9%) patients. There was pneumothorax with spontaneous resolution in two (1.6%) patients, with one in the first series and one in the second series. In addition, two (1.6%) cases in the first series suffered suture site infection. There were two (1.6%) cases of bar displacement that did not require surgery to remove the bar.</p><p id="para160" class="elsevierStylePara elsevierViewall">Major complications were observed in eight (6.5%) patients. Skin erosion/seroma occurred in one (0.8%) patient in the first series. In the second-series patients, we observed pleural effusion requiring drainage in one (0.8%) patient, a reaction to the bar (ABA foreign body reaction) in one (0.8%) patient, pneumonia and septic shock in one (0.8%) patient and cardiac perforation in one (0.8%) patient. Bar displacement that required bar removal occurred in three (2.5%) patients, two who were in the first series and one who was in the second series.</p><p id="para170" class="elsevierStylePara elsevierViewall">When the incidence of minor complications was compared among the three series, the only complication that presented a significant difference was suture infection (<span class="elsevierStyleItalic">p</span> = 0.036).</p><p id="para180" class="elsevierStylePara elsevierViewall">The incidence of bar displacement was the only major complication that was significantly different among the three series (<a class="elsevierStyleCrossRef" href="#fig3">Figure 3</a>).</p><elsevierMultimedia ident="fig3"></elsevierMultimedia><p id="para190" class="elsevierStylePara elsevierViewall">We were able to remove the bar after the three-year follow-up period in 37 (30.3%) of the 122 patients. In two (1.6%) patients the bar was removed within 2.5 years of placement. In one case, the removal was performed because of a persistent wound infection following a thoracic trauma with skin erosion. The other early removal was performed at the patient's request, as it was his desire to join the Navy. In all of these patients, the contour of the chest wall obtained after surgical correction was maintained.</p></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">DISCUSSION</span><p id="para200" class="elsevierStylePara elsevierViewall">The rate of bar displacement following the original Nuss procedure was 15%; however, the introduction of stabilizers reduced this rate to 5%. According to some authors, the rate can be lowered even further with the addition of pericostal sutures placed around the bar.<a class="elsevierStyleCrossRefs" href="#bib1">1,7,8</a></p><p id="para210" class="elsevierStylePara elsevierViewall">Hebra et al.<a class="elsevierStyleCrossRef" href="#bib3">3</a> were the first to advocate the placement of a suture around the bar and the underlying ribs, which they called “third point fixation.” In our second series of patients (patients 25–71), we used this technique. The main complaints reported by our patients in the first postoperative month were thoracic pain and discomfort close to the fixation points, perhaps due to compression of the intercostal bundle. With this technical modification to our procedure, the incidence of bar displacement dropped from four (16.6%) in the first series of patients to one (2.1%) in the second series.</p><p id="para220" class="elsevierStylePara elsevierViewall">Park et al.<a class="elsevierStyleCrossRef" href="#bib7">7</a> described a variety of mechanisms governing bar displacement that we also observed in our cases, such as flipping, lateral sliding, and a backward shift. Flipping is most common at the hinge-point, with the bar sliding laterally towards the more depressed side and/or shifting backward, and is often accompanied by a breakdown in the intercostal muscles. While they advocated a fifth wire stitched on the right side at the hinge-point or several pericostal wires to attain the desired firmness,<a class="elsevierStyleCrossRef" href="#bib8">8</a> the rupture of the wire sutures used to secure the stabilizer and/or bar on the underlying rib is a common complication reported in 27.8% of the cases.<a class="elsevierStyleCrossRef" href="#bib1">1</a> Furthermore, the broken wire can hamper removal of the bar by requiring the surgeon to find and extract minute wire pieces. As a result, residual wire fragments remain embedded under the ribs of some patients. Therefore, dispensing with wire stitching is a welcome development in the Nuss technique.</p><p id="para230" class="elsevierStylePara elsevierViewall">Recently, the use of two bars has been reported<a class="elsevierStyleCrossRef" href="#bib4">4</a> to increase stability and enhance the aesthetic results. Vergunta et al.<a class="elsevierStyleCrossRef" href="#bib2">2</a> advocates routinely placing two bars, with a stabilizing plate for each, on opposite sides of the chest. They justify this by noting that “a single bar can be inherently unstable because the deepest point of the sternum is balanced on only the center of one bar. Two bars placed above and below the midpoint of the deformity provides for increased stability”. However, there are no data comparing the morbidity associated with one or two or more bars.</p><p id="para240" class="elsevierStylePara elsevierViewall">Instead of using two bars to avoid displacement, we chose to use one stabilizer at each side of the bar, distributing the forces to at least two ribs. The two stabilizers provide a stable basis for the correction we observed in all patients in our third series (<a class="elsevierStyleCrossRef" href="#fig4">Figure 4</a>).</p><elsevierMultimedia ident="fig4"></elsevierMultimedia><p id="para250" class="elsevierStylePara elsevierViewall">In our third series of patients, we followed the recommendations of Pilegaard et al.,<a class="elsevierStyleCrossRef" href="#bib9">9</a> who, in 2008, concluded that their procedure may have reduced the incidence of bar displacement in 383 patients. These authors modified the original Nuss technique by using a shorter <span class="elsevierStyleItalic">pectus</span> bar and placing the stabilizer on the left side of the bar as close as possible to the entry of the thoracic cavity.</p><p id="para260" class="elsevierStylePara elsevierViewall">Several factors work against the lateral position of the stabilizer. According to Watanabe et al.,<a class="elsevierStyleCrossRef" href="#bib10">10</a> due to its size, the use of a stabilizer in a lateral position increases the incidence of wound complications, such as seroma and dermatitis due to pressure damage. In one patient in our first series, the stabilizer had to be removed to control seroma, dermatitis, and skin erosion due to pressure damage. When the stabilizer was placed more medially, it was at least partially covered with the <span class="elsevierStyleItalic">pectoralis major</span> muscle.</p><p id="para270" class="elsevierStylePara elsevierViewall">To summarize, we would like to emphasize some concepts already published and that we have been following:<a class="elsevierStyleCrossRef" href="#bib11">10</a><ul class="elsevierStyleList" id="celist10"><li class="elsevierStyleListItem" id="celistitem10"><span class="elsevierStyleLabel">1)</span><p id="para280" class="elsevierStylePara elsevierViewall">small bars are probably more stable than large bars;</p></li><li class="elsevierStyleListItem" id="celistitem20"><span class="elsevierStyleLabel">2)</span><p id="para290" class="elsevierStylePara elsevierViewall">the placement of the bar should be at the deepest point of the excavatum deformity (<a class="elsevierStyleCrossRef" href="#fig5">Figure 5</a>);</p><elsevierMultimedia ident="fig5"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="celistitem30"><span class="elsevierStyleLabel">3)</span><p id="para300" class="elsevierStylePara elsevierViewall">older, asymmetric, or severe deformities may require placement of an additional bar or may require another method of correction;</p></li><li class="elsevierStyleListItem" id="celistitem40"><span class="elsevierStyleLabel">4)</span><p id="para310" class="elsevierStylePara elsevierViewall">bar should be secured with two stabilizers positioned medially, as close as possible to the hinge-point.</p></li></ul></p><p id="para320" class="elsevierStylePara elsevierViewall">In conclusion, the use of these measures can prevent bar instability as demonstrated in our comparison of the incidence of bar displacement in our three series of patients (<span class="elsevierStyleItalic">p</span><0.05).</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:7 [ 0 => array:2 [ "identificador" => "xpalclavsec1582223" "titulo" => "KEYWORDS" ] 1 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 2 => array:2 [ "identificador" => "cesec20" "titulo" => "PATIENTS AND METHODS" ] 3 => array:2 [ "identificador" => "cesec30" "titulo" => "RESULTS" ] 4 => array:2 [ "identificador" => "cesec40" "titulo" => "DISCUSSION" ] 5 => array:2 [ "identificador" => "xack639235" "titulo" => "ACKNOWLEDGMENTS" ] 6 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2011-06-05" "fechaAceptado" => "2011-06-30" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1582223" "palabras" => array:5 [ 0 => "<span class="elsevierStyleItalic">Pectus excavatum</span>" 1 => "Nuss technique" 2 => "<span class="elsevierStyleItalic">Pectus</span> bar" 3 => "Bar displacement" 4 => "Bar instability" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">OBJECTIVES:</span><p id="spara70" class="elsevierStyleSimplePara elsevierViewall">To compare bar displacement and complication rates in three retrospective series of patients operated on by the same surgical team.</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">METHOD:</span><p id="spara80" class="elsevierStyleSimplePara elsevierViewall">A retrospective medical chart analysis of the three patient series was performed. In the first series, the original, unmodified Nuss technique was performed. In the second, we used the “third point fixation” technique, and in the last series, the correction was performed with modifications to the stabilizer and stabilizer position.</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">RESULTS:</span><p id="spara90" class="elsevierStyleSimplePara elsevierViewall">There were no deaths in any of the series. Minor complications occurred in six (4.9%) patients: pneumothorax with spontaneous resolution (2), suture site infection (2), and bar displacement without the reoperation need (2). Major complications were observed in eight (6.5%) patients: pleural effusion requiring drainage (1), foreign body reaction to the bar (1), pneumonia and shock septic (1), cardiac perforation (1), skin erosion/seroma (1), and displacement that necessitated a second operation to remove the bar within the 30 days of implantation (3). All major complications occurred in the first and second series.</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">CONCLUSION:</span><p id="spara100" class="elsevierStyleSimplePara elsevierViewall">The elimination of fixation wires, the use of shorter bars and redesigned stabilizers placed in a more medial position results in a better outcome for <span class="elsevierStyleItalic">pectus excavatum</span> patients treated with the Nuss technique. With bar displacement and instability no longer significant postoperative risks, the Nuss technique should be considered among the available options for the surgical correction of <span class="elsevierStyleItalic">pectus excavatum</span> in pediatric patients.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "ceabs10" "titulo" => "OBJECTIVES:" ] 1 => array:2 [ "identificador" => "ceabs20" "titulo" => "METHOD:" ] 2 => array:2 [ "identificador" => "ceabs30" "titulo" => "RESULTS:" ] 3 => array:2 [ "identificador" => "ceabs40" "titulo" => "CONCLUSION:" ] ] ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara" id="cenpara10">No potential conflict of interest was reported.</p>" ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 332 "Ancho" => 498 "Tamanyo" => 17480 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">A and B: Examples of bar displacement.</p>" ] ] 1 => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 248 "Ancho" => 498 "Tamanyo" => 15975 ] ] "descripcion" => array:1 [ "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">New positioning of the stabilizer.</p>" ] ] 2 => array:7 [ "identificador" => "fig3" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 274 "Ancho" => 478 "Tamanyo" => 10775 ] ] "descripcion" => array:1 [ "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">The incidence of bar displacement in the three series.</p>" ] ] 3 => array:7 [ "identificador" => "fig4" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 275 "Ancho" => 452 "Tamanyo" => 24117 ] ] "descripcion" => array:1 [ "en" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">A and B: Examples of the new technique.</p>" ] ] 4 => array:7 [ "identificador" => "fig5" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 274 "Ancho" => 498 "Tamanyo" => 20615 ] ] "descripcion" => array:1 [ "en" => "<p id="spara50" class="elsevierStyleSimplePara elsevierViewall">A) One stabilizer, with two different, non-parallel planes between the bar and internal surface of the sternum. B) Two stabilizers, with two different, parallel planes.</p>" ] ] 5 => array:7 [ "identificador" => "tbl1" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="top" scope="col">Complication \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">First series (<span class="elsevierStyleItalic">n</span> = 24) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Second series (<span class="elsevierStyleItalic">n</span> = 47) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Third series (<span class="elsevierStyleItalic">n</span> = 51) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Pneumothorax \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1 (4.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1 (2.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Suture infection \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2 (8.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Pleural effusion \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1 (2.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Reaction to the bar \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1 (2.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Skin erosion/seroma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1 (4.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Pneumonia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1 (2.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Cardiac perforation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1 (2.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top" style="border-bottom: 2px solid black">Bar displacement \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">4 (16.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">1 (2.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top" style="border-bottom: 2px solid black">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara60" class="elsevierStyleSimplePara elsevierViewall">Minor and major complications observed in the three series.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => 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1 => """ JC Das-Neves-Pereira \n \t\t\t\t\t\t\t\t """ 2 => """ KM Lopes \n \t\t\t\t\t\t\t\t """ 3 => """ FB Jatene \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.ejcts.2009.03.061" "Revista" => array:6 [ "tituloSerie" => "Eur J Cardiothorac Surg" "fecha" => "2009" "volumen" => "36" "paginaInicial" => "410" "paginaFinal" => "412" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19464908" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.ejcts.2009.03.061" "WWW" => array:1 [ "link" => "10.1016/j.ejcts.2009.03.061" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Technical modifications of the Nuss operation for the correction of pectus excavatum" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ JR de Campos \n \t\t\t\t\t\t\t\t """ 1 => """ MH Fonseca \n \t\t\t\t\t\t\t\t """ 2 => """ C Werebe Ede \n \t\t\t\t\t\t\t\t """ 3 => """ FB Velhote MC Jatene \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1590/s1807-59322006000200018" "Revista" => array:7 [ "tituloSerie" => "Clinics" "fecha" => "2006" "volumen" => "61" "paginaInicial" => "185" "paginaFinal" => "186" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16680340" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0959804919301455" "estado" => "S300" "issn" => "09598049" ] ] ] 1 => array:2 [ "doi" => "10.1590/s1807-59322006000200018" "WWW" => array:1 [ "link" => "10.1590/S1807-59322006000200018" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Nuss procedure for pectus excavatum: evolution of techniques and early results on 322 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => 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