Letter to the Editor
Osteomalacia and Vitamin D Deficiency in the Elderly
Maria do Carmo Sitta
, Stella V.A. Cassis, Nidia C Horie, Rosa M.A. Moyses, Vanda Jorgetti, Luíz Eugênio Garcez-Leme
Corresponding author
Geriatrics – Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo/SP, Brazil
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Cassis, Nidia C Horie, Rosa M.A. Moyses, Vanda Jorgetti, Luíz Eugênio Garcez-Leme" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Maria do Carmo" "apellidos" => "Sitta" "email" => array:1 [ 0 => "m.sitta@globo.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "c1" ] ] ] 1 => array:2 [ "nombre" => "Stella V.A." "apellidos" => "Cassis" ] 2 => array:2 [ "nombre" => "Nidia C" "apellidos" => "Horie" ] 3 => array:2 [ "nombre" => "Rosa M.A." "apellidos" => "Moyses" ] 4 => array:2 [ "nombre" => "Vanda" "apellidos" => "Jorgetti" ] 5 => array:2 [ "nombre" => "Luíz Eugênio" "apellidos" => "Garcez-Leme" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Geriatrics – Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo/SP, Brazil" "identificador" => "af1" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "c1" "etiqueta" => "*" "correspondencia" => "Tel.: 55 113069-7813" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1 -" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 698 "Ancho" => 993 "Tamanyo" => 49433 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Bone scintigraphy on patient: multiple areas of osteogenic reaction</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">Osteomalacia is one of the most common osteometabolic diseases among the elderly and may be associated with osteoporosis.<a class="elsevierStyleCrossRef" href="#bib1">1</a> It is typically caused by lack of vitamin D and is characterized by mineralization deficiency of the osteoid matrix in the cortical and trabecular bone, resulting in accumulation of osteoid tissue.<a class="elsevierStyleCrossRef" href="#bib2">2</a> Vitamin D deficiency is a pathogenic factor of osteoporosis that can be modified.<a class="elsevierStyleCrossRef" href="#bib5">5</a>, <a class="elsevierStyleCrossRef" href="#bib9">9</a> The elderly are at particularly high risk for developing osteomalacia, which is frequently misdiagnosed.<a class="elsevierStyleCrossRef" href="#bib1">1</a>, <a class="elsevierStyleCrossRef" href="#bib3">3</a></p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">SAMPLE AND METHODS</span><p id="para20" class="elsevierStylePara elsevierViewall">We report the case of a 62-year-old woman who had experienced body pains and weakness for two years. She had suffered from multiple fractures of the ribs and the left clavicle without trauma for two months before she was admitted to the hospital. Comorbidities included hypertension, diabetes mellitus, hypothyroidism, depression and neurological sequelae with left hemiparesis. The patient was using levothyroxine, omeprazole, metformin, glymepiride, milnacipran, mirtazapine and atenolol. Radiography showed fractures of nine costal arches and of the left clavicle. Bone scintigraphy revealed multiple osteogenic reaction areas, with predominance in the axial skeleton (<a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a>). Bone densitometry showed osteoporosis with a lumbar spine (L1–L4) T score of −3.1 and a femur (neck) T score of −2.8. The laboratory test results showed alkaline phosphatase (AP) 491 U/L (RR-ref range < 104 U/L); parathyroid hormone (PTH) 146 pg/ml (RR 7–62 pg/ml); total serum calcium 8.5 mg/dl (RR 8.6–10.2 mg/dl); ionized calcium 4.7 mg/dl (RR 4.6–5.3 mg/dl); serum phosphorus 3.6 mg/dl (RR 2.7–4.5 mg/dl); urinary calcium 42.3 mg/24h (RR 100–320 mg/24h); and urinary phosphate 397.4 mg/24 h (RR 400–1300 mg/24h).</p><elsevierMultimedia ident="fig1"></elsevierMultimedia><p id="para30" class="elsevierStylePara elsevierViewall">These findings led us to hypothesize that the patient had osteomalacia. It was decided to perform a trans-iliac bone biopsy. The patient was pre-labeled with oral tetracycline (20 mg/kg/day for 3 days) administered over two separate intervals 10 days apart.</p><p id="para40" class="elsevierStylePara elsevierViewall">The biopsy revealed diminished trabecular volume (13.3%), increased osteoid surface (82%) and volume (43%), and confluent tetracycline labeling (<a class="elsevierStyleCrossRef" href="#fig2">Figure 2</a>); thus, the hypothesis was confirmed. Serum 25-OH-vitamin D levels were determined to be 11 ng/ml (RR > 40 ng/ml). The patient was prescribed calcitriol at 0.75 mg/day and 2 g of calcium carbonate to normalize PTH and alkaline phosphatase (AP) levels. Body pains and weakness were eventually reduced. Over a follow-up period of three years, the patient did not have any new fractures. Her bone mineral density improved by 38% in the lumbar spine (L1-L4 T-score −0.56) and 67.3% in the femur (neck T-score −1.21). Laboratory test levels had normalized to alkaline phosphatase (AP) 81 U/L (RR-ref range < 104 U/L); parathormone (PTH) 53 pg/ml (RR 7–62 pg/ml); total serum calcium 9.4 mg/dl (RR 8.6–10.2 mg/dl); ionized calcium 4.9 mg/dl (RR 4.6–5.3 mg/dl); serum phosphorus 4.4 mg/dl (RR 2.7–4.5 mg/dl); urinary calcium 151 mg/24 h (RR 100–320 mg/24 h) and serum 25-OH-vitamin D 42 ng/ml (RR > 40 ng/ml). At present, the patient is using colecalciferol at 1000UI a day with good results.</p><elsevierMultimedia ident="fig2"></elsevierMultimedia></span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">DISCUSSION</span><p id="para50" class="elsevierStylePara elsevierViewall">Vitamin D plays a role in bone mineralization and in the regulation of circulating calcium. Deficiency of this vitamin results in increased parathyroid hormone (PTH) synthesis and secretion.<a class="elsevierStyleCrossRef" href="#bib5">5</a> This secondary hyperparathyroidism increases bone turnover, resulting in increased risk of fracture.<a class="elsevierStyleCrossRef" href="#bib1">1</a> Osteomalacia develops when this process is intense and chronic and was histologically apparent in 13 to 33% of patients with osteoporotic femoral neck fractures.<a class="elsevierStyleCrossRef" href="#bib1">1</a>, <a class="elsevierStyleCrossRef" href="#bib5">5</a></p><p id="para60" class="elsevierStylePara elsevierViewall">Vitamin D deficiency has been implicated in osteoporotic pathophysiology of the elderly and can cause muscle weakness as well as predisposition to falls and fractures. Osteomalacia may be associated with fractures due to minimal stress trauma and should be suspected when laboratory exams show increased levels of alkaline phosphatase (AP) with normal or decreased serum calcium and phosphorus, increased PTH (secondary hyperparathyroidism), and absence of lithic lesions and neoplasic bone disease. In most cases, osteomalacia can be diagnosed by assaying for 25-OH-vitamin D,<a class="elsevierStyleCrossRef" href="#bib8">8</a> which can be useful for early detection of the deficiency. Vitamin D3, or cholecalciferol, is synthesized in the skin by ultraviolet radiation from the sun. In order to become active, it must furthermore undergo two hydroxylations in the liver and kidneys.<a class="elsevierStyleCrossRef" href="#bib5">5</a> Low intake, poor absorption, and insufficient exposure to the sun can all result in Vitamin D deficiency. In some cases, the defect occurs in the receptor, and the diagnosis can only be confirmed through bone biopsy, which also allows for differentiation between osteomalacia and osteoporosis.<a class="elsevierStyleCrossRef" href="#bib2">2</a></p><p id="para70" class="elsevierStylePara elsevierViewall">Cancer and prolonged use of anticonvulsants such phenytoin can also cause osteomalacia. The main differential diagnosis is osteoporosis, which shows normal results on biochemical tests for calcium, phosphorus, AP and PTH. Vitamin D deficits among the elderly have been reported in several countries,<a class="elsevierStyleCrossRef" href="#bib1">1</a>,<a class="elsevierStyleCrossRef" href="#bib3">3</a>,<a class="elsevierStyleCrossRef" href="#bib4">4</a>,<a class="elsevierStyleCrossRef" href="#bib8">8</a> even in Brazil, despite its tropical location.<a class="elsevierStyleCrossRef" href="#bib5">5</a> Vitamin D deficiency has been implicated in various pathological conditions including osteoporosis, muscle weakness and predisposition to falls and fractures.<a class="elsevierStyleCrossRef" href="#bib4">4</a>,<a class="elsevierStyleCrossRef" href="#bib7">7</a>,<a class="elsevierStyleCrossRef" href="#bib10">10</a>,<a class="elsevierStyleCrossRef" href="#bib11">11</a> Epidemiological studies suggest that adequate serum concentrations of Vitamin D are related to reduced risk of autoimmune diseases, falls,<a class="elsevierStyleCrossRef" href="#bib9">9</a> and prostate, colon, breast and ovarian cancer.<a class="elsevierStyleCrossRef" href="#bib6">6</a>,<a class="elsevierStyleCrossRef" href="#bib9">9</a></p></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">CONCLUSION</span><p id="para80" class="elsevierStylePara elsevierViewall">Vitamin D deficit may cause osteomalacia, which should be included in the differential diagnosis for fractures caused by minimal trauma. It is suggested that Vitamin D assays should be included in routine assessments of the elderly and that Vitamin D supplementation should be considered even in tropical countries.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:5 [ 0 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 1 => array:2 [ "identificador" => "cesec20" "titulo" => "SAMPLE AND METHODS" ] 2 => array:2 [ "identificador" => "cesec30" "titulo" => "DISCUSSION" ] 3 => array:2 [ "identificador" => "cesec40" "titulo" => "CONCLUSION" ] 4 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1 -" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 698 "Ancho" => 993 "Tamanyo" => 49433 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Bone scintigraphy on patient: multiple areas of osteogenic reaction</p>" ] ] 1 => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2 -" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 774 "Ancho" => 2044 "Tamanyo" => 305697 ] ] "descripcion" => array:1 [ "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Biopsy of patient - bone trabecula; bone medulla; osteoid matrix. Absence of double tetracycline labeling</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Occult vitamin D deficiency in postmenopausal US women with acute hip fracture" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ Ms LeBoff \n \t\t\t\t\t\t\t\t """ 1 => """ L Kohlmeier \n \t\t\t\t\t\t\t\t """ 2 => """ S Hurwitz \n \t\t\t\t\t\t\t\t """ 3 => """ J Frankling \n \t\t\t\t\t\t\t\t """ 4 => """ J Wright \n \t\t\t\t\t\t\t\t """ 5 => """ J Glowacki \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.281.16.1505" "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1999" "volumen" => "281" "paginaInicial" => "1505" "paginaFinal" => "1511" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10227320" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Papel da histomorfometria óssea no diagnóstico diferencial da Osteomalácia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ PHS Correia \n \t\t\t\t\t\t\t\t """ 1 => """ V Jorgetti \n \t\t\t\t\t\t\t\t """ 2 => """ MOR Leite \n \t\t\t\t\t\t\t\t """ 3 => """ EL Arioli \n \t\t\t\t\t\t\t\t """ 4 => """ JR Batalha \n \t\t\t\t\t\t\t\t """ 5 => """ A Borelli \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arq Bras Endocrinol Metab" "fecha" => "2000" "volumen" => "44" "paginaInicial" => "148" "paginaFinal" => "152" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vitamin D and intact PTH status in patients with hip fracture" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ M Sakuma \n \t\t\t\t\t\t\t\t """ 1 => """ N Endo \n \t\t\t\t\t\t\t\t """ 2 => """ T Oinuma \n \t\t\t\t\t\t\t\t """ 3 => """ T Hayami \n \t\t\t\t\t\t\t\t """ 4 => """ E Endo \n \t\t\t\t\t\t\t\t """ 5 => """ T Yazaka \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Osteoporosis Int" "fecha" => "2006" "volumen" => "17" "paginaInicial" => "1608" "paginaFinal" => "1614" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lightening the fracture load: growing evidence suggests many older New Zealanders would benefit from more vitamin D. 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"autores" => array:4 [ 0 => """ N Binkley \n \t\t\t\t\t\t\t\t """ 1 => """ D Krueger \n \t\t\t\t\t\t\t\t """ 2 => """ D Gemar \n \t\t\t\t\t\t\t\t """ 3 => """ MK Drezner \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Clin Endocrinol Metabol" "fecha" => "2008" "volumen" => "93" "paginaInicial" => "1804" "paginaFinal" => "1808" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vitamin D Supplementation and Total Mortality: A Meta-analysis of Randomized Controlled Trials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ P Autier \n \t\t\t\t\t\t\t\t """ 1 => """ S Gandini \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Int Med" "fecha" => "2007" "volumen" => "167" "paginaInicial" => "1730" "paginaFinal" => 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array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Calcium plus Vitamin D Supplementation and the Risk of Fractures" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ RD Jackson \n \t\t\t\t\t\t\t\t """ 1 => """ AZ LaCroix \n \t\t\t\t\t\t\t\t """ 2 => """ M Gass \n \t\t\t\t\t\t\t\t """ 3 => """ RB Wallace \n \t\t\t\t\t\t\t\t """ 4 => """ J Robbins \n \t\t\t\t\t\t\t\t """ 5 => """ CE Lewis \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa055218" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2006" "volumen" => "354" "paginaInicial" => "669" "paginaFinal" => "683" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16481635" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/18075932/0000006400000002/v1_202212060837/S1807593222026965/v1_202212060837/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/18075932/0000006400000002/v1_202212060837/S1807593222026965/v1_202212060837/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222026965?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 1 | 3 |
| 2024 October | 57 | 37 | 94 |
| 2024 September | 41 | 40 | 81 |
| 2024 August | 48 | 42 | 90 |
| 2024 July | 44 | 37 | 81 |
| 2024 June | 36 | 26 | 62 |
| 2024 May | 38 | 19 | 57 |
| 2024 April | 37 | 18 | 55 |
| 2024 March | 56 | 14 | 70 |
| 2024 February | 46 | 21 | 67 |
| 2024 January | 35 | 26 | 61 |
| 2023 December | 37 | 34 | 71 |
| 2023 November | 41 | 32 | 73 |
| 2023 October | 54 | 39 | 93 |
| 2023 September | 24 | 23 | 47 |
| 2023 August | 32 | 11 | 43 |
| 2023 July | 32 | 7 | 39 |
| 2023 June | 24 | 4 | 28 |
| 2023 May | 33 | 4 | 37 |
| 2023 April | 26 | 2 | 28 |
| 2023 March | 9 | 4 | 13 |
| 2023 February | 1 | 8 | 9 |
| 2023 January | 0 | 3 | 3 |
| 2022 December | 10 | 1 | 11 |
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