Clinical Science
Sonographic Assessment of Renal Growth in Patients with Beckwith-Wiedemann Syndrome: The Beckwith-Wiedemann Syndrome Renal Nomogram
Clara L Ortiz-Neira
, Jeffrey Traubici, Daneman Alan, Rahim Moineddin, Cheryl Shuman, Rosanna Weksberg, Monica Epelman
Corresponding author
Alberta Children’s Hospital - Toronto, Ontario, Canada
Read
665
Timeswas read the article
255
Total PDF
410
Total HTML
Share statistics
array:24 [ "pii" => "S1807593222027041" "issn" => "18075932" "doi" => "10.1590/S1807-59322009000100008" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "2704" "copyright" => "CLINICS" "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "fla" "cita" => "Clinics. 2009;64:41-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S1807593222027053" "issn" => "18075932" "doi" => "10.1590/S1807-59322009000100009" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "2705" "copyright" => "CLINICS" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "fla" "cita" => "Clinics. 2009;64:45-50" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Clinical Science</span>" "titulo" => "Quality of Life and Multimorbidity of Elderly Outpatients" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "45" "paginaFinal" => "50" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2 -" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1193 "Ancho" => 1855 "Tamanyo" => 123482 ] ] "descripcion" => array:1 [ "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Correlation between self-evaluation of health and World Health Organization quality of life-BRIEF (WHOQOL-BRIEF) score for each domain</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Thaís Cano Miranda de Nóbrega, Omar Jaluul, Adriana Nunes Machado, Sérgio M.P. Paschoal, Wilson Jacob Filho" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Thaís Cano Miranda" "apellidos" => "de Nóbrega" ] 1 => array:2 [ "nombre" => "Omar" "apellidos" => "Jaluul" ] 2 => array:2 [ "nombre" => "Adriana Nunes" "apellidos" => "Machado" ] 3 => array:2 [ "nombre" => "Sérgio M.P." "apellidos" => "Paschoal" ] 4 => array:2 [ "nombre" => "Wilson Jacob" "apellidos" => "Filho" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222027053?idApp=UINPBA00004N" "url" => "/18075932/0000006400000001/v1_202212060707/S1807593222027053/v1_202212060707/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S180759322202703X" "issn" => "18075932" "doi" => "10.1590/S1807-59322009000100007" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "2703" "copyright" => "CLINICS" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "fla" "cita" => "Clinics. 2009;64:35-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Clinical Science</span>" "titulo" => "Global Body Posture Evaluation in Patients with Temporomandibular Joint Disorder" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "35" "paginaFinal" => "39" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Eliza Tiemi Saito, Paula Marie Hanai Akashi, Isabel de Camargo Neves Sacco" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Eliza Tiemi" "apellidos" => "Saito" ] 1 => array:2 [ "nombre" => "Paula Marie Hanai" "apellidos" => "Akashi" ] 2 => array:2 [ "nombre" => "Isabel" "apellidos" => "de Camargo Neves Sacco" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S180759322202703X?idApp=UINPBA00004N" "url" => "/18075932/0000006400000001/v1_202212060707/S180759322202703X/v1_202212060707/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Clinical Science</span>" "titulo" => "Sonographic Assessment of Renal Growth in Patients with Beckwith-Wiedemann Syndrome: The Beckwith-Wiedemann Syndrome Renal Nomogram" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "41" "paginaFinal" => "44" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Clara L Ortiz-Neira, Jeffrey Traubici, Daneman Alan, Rahim Moineddin, Cheryl Shuman, Rosanna Weksberg, Monica Epelman" "autores" => array:7 [ 0 => array:4 [ "nombre" => "Clara L" "apellidos" => "Ortiz-Neira" "email" => array:1 [ 0 => "claraneira@shaw.ca" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "c1" ] ] ] 1 => array:2 [ "nombre" => "Jeffrey" "apellidos" => "Traubici" ] 2 => array:2 [ "nombre" => "Daneman" "apellidos" => "Alan" ] 3 => array:2 [ "nombre" => "Rahim" "apellidos" => "Moineddin" ] 4 => array:2 [ "nombre" => "Cheryl" "apellidos" => "Shuman" ] 5 => array:2 [ "nombre" => "Rosanna" "apellidos" => "Weksberg" ] 6 => array:2 [ "nombre" => "Monica" "apellidos" => "Epelman" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Alberta Children’s Hospital - Toronto, Ontario, Canada" "identificador" => "af1" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "c1" "etiqueta" => "*" "correspondencia" => "Tel.: 403-955-2339" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig3" "etiqueta" => "Figure 3-" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 470 "Ancho" => 659 "Tamanyo" => 31833 ] ] "descripcion" => array:1 [ "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Renal length and growth of the left kidney in patients with Beckwith-Wiedemann syndrome (BWS)</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">Beckwith-Wiedemann syndrome (BWS), a disorder of somatic overgrowth first described by Beckwith in 1963<a class="elsevierStyleCrossRef" href="#bib1">1</a> and subsequently by Wiedemann in 1964,<a class="elsevierStyleCrossRef" href="#bib2">2</a> is a congenital disorder associated with the disruption of the genomic imprinting of one or more genes in the 11p 15.5 region.<a class="elsevierStyleCrossRef" href="#bib3">3</a> Many of these genes are involved in the promotion or suppression of growth.<a class="elsevierStyleCrossRef" href="#bib4">4</a> The cardinal features of the syndrome include macroglossia, abdominal wall defects, and macrosomia.<a class="elsevierStyleCrossRef" href="#bib1">1</a> A number of other features have been documented, including neonatal hypoglycemia and hemihyperplasia.<a class="elsevierStyleCrossRef" href="#bib1">1</a>,<a class="elsevierStyleCrossRef" href="#bib2">2</a> Patients with BWS also have an increased risk of developing embryonal tumors, the most common of which is the Wilms tumor.<a class="elsevierStyleCrossRef" href="#bib5">5</a> Other lesions reported include hepatoblastoma, neuroblastoma, adrenocortical carcinoma, and rhabdomyosarcoma.<a class="elsevierStyleCrossRef" href="#bib1">1</a></p><p id="para20" class="elsevierStylePara elsevierViewall">Given the increased risk of embryonal tumors, screening protocols have been implemented to detect tumors in children at a younger age and earlier stage of disease. Evidence of kidney overgrowth is a diagnostic criterion that may be used to help identify those patients who are at greatest risk of developing Wilms tumors.<a class="elsevierStyleCrossRef" href="#bib5">5</a> A number of entities, both acute and chronic, can cause deviations in renal size. For BWS, the size of the kidney is typically larger than that of age-matched normal controls.<a class="elsevierStyleCrossRef" href="#bib5">5</a> There exist numerous sonographic reports<a class="elsevierStyleCrossRef" href="#bib1">1</a>,<a class="elsevierStyleCrossRef" href="#bib3">3</a>,<a class="elsevierStyleCrossRefs" href="#bib5">5–6</a> of morphological changes, tumors, and other associated processes for patients with BWS, although no renal chart depicting the expected growth of kidneys for these patients has ever been published.</p><p id="para30" class="elsevierStylePara elsevierViewall">When children with BWS are examined using ultrasound, the renal length is measured and compared with published nomograms to determine whether kidney size is normal for the patient’s age or is outside the usual ranges. Since no nomograms have ever been established for children with BWS, we use either nomograms for unaffected children or no nomograms at al.</p><p id="para40" class="elsevierStylePara elsevierViewall">The aim of this study was to create a nomogram that could be used to assess renal growth in children with BWS because this is an integral part of their clinical care. Such a chart should serve as a predictive tool to evaluate expected renal growth in this patient population.</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">MATERIALS AND METHODS</span><p id="para50" class="elsevierStylePara elsevierViewall">All BWS patients followed at our institution from 1996 to 2004 were eligible to participate in this study. Patients were excluded from the study if they had a urinary tract infection at the time of their examination, hydronephrosis, a previous or partial nephrectomy, a tumor, or a solitary kidney. In our study group, nine patients had Wilms tumors at the time of their diagnosis; consequently, we had no information about the baseline size of these patients’ kidneys. If the images for a patient were of poor quality or if serial studies were unavailable, that patient was also excluded from the study.</p><p id="para60" class="elsevierStylePara elsevierViewall">At our institution, a renal ultrasound is performed every six months for this population. The renal ultrasound examination consists of imaging the kidneys with the patient supine in the longitudinal and transverse planes. The kidneys are also assessed, if possible, with the patient in the prone position. We collected kidney measurements for each patient enrolled in the study from 1996 to 2004. All ultrasound studies were performed using ATL (Advanced Technological Laboratories, Bothel, WA) 3,000 or 5,000, Acuson Sequoia, and General Electric Ultrasound Systems (Brookfield, WI). The curvilinear and linear transducers ranged from 3 to 12 MHz. The length of the kidney was measured with a curvilinear transducer and with the patient supine. The lengths of both kidneys were measured with real-time ultrasound for all BWS patients.</p><p id="para70" class="elsevierStylePara elsevierViewall">We compared the data for the patients in our study with those of age-matched controls reported by Rosenbaum et al.<a class="elsevierStyleCrossRef" href="#bib6">6</a> We correlated morphometric kidney data, such as kidney length, with the patient’s age in months during the first year and then with years of age, using linear regression.</p><p id="para80" class="elsevierStylePara elsevierViewall">We superimposed growth charts for kidney lengths and 95% confidence limits for patients in our study population onto measurements of kidney lengths in normal children from the 1984 study of Rosenbaum et al.<a class="elsevierStyleCrossRef" href="#bib6">6</a> We used linear regression models to establish the linear relationship between age and the average length of the kidneys for children with BWS and for the age-matched controls (<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>). We used two-sample t-tests to compare average kidney sizes in our study with normal kidney sizes as reported by Rosenbaum et al.<a class="elsevierStyleCrossRef" href="#bib6">6</a> for different age groups.</p><elsevierMultimedia ident="tbl1"></elsevierMultimedia><p id="para90" class="elsevierStylePara elsevierViewall">We used SAS version 8.2 (SAS Institute, Cary, NC) for data manipulation and analysis. We considered a p-value ≤ 0.05 statistically significant.</p></span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">RESULTS</span><p id="para100" class="elsevierStylePara elsevierViewall">Ninety-six children with BWS were followed from 1996 to 2004. Forty-three of these patients met our criteria for inclusion in the study: 28 girls (65%) and 15 boys (35%).</p><p id="para110" class="elsevierStylePara elsevierViewall">A linear relationship between length of kidney and patient age was found for both patients with BWS and for normal controls as reported by Rosenbaum et al<a class="elsevierStyleCrossRef" href="#bib6">6</a> (<a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a>). No statistically significant difference in the length of kidneys was found between boys and girls (p=0.2153). There were no differences between the left and right kidneys (p=0.9613).</p><elsevierMultimedia ident="fig1"></elsevierMultimedia><p id="para120" class="elsevierStylePara elsevierViewall">Nonparametric smooth curves fitted to both right (<a class="elsevierStyleCrossRef" href="#fig2">Figure 2</a>) and left (<a class="elsevierStyleCrossRef" href="#fig3">Figure 3</a>) kidney lengths clearly show the linear relationship between kidney length and age in months for children less than 1 year, and age in years for children older than 1 year. The slope of the regression lines changes at 12 months. Since the nonparametric smooth curves fitted to the data for the left and right kidney lengths were almost identical (<a class="elsevierStyleCrossRef" href="#fig4">Fig. 4</a>), we used the average of the lengths of the left and right kidneys in our linear regression models to estimate the relationship between kidney size and age among children with BWS.</p><elsevierMultimedia ident="fig2"></elsevierMultimedia><elsevierMultimedia ident="fig3"></elsevierMultimedia><elsevierMultimedia ident="fig4"></elsevierMultimedia><p id="para130" class="elsevierStylePara elsevierViewall">Eight of our 43 patients with BWS were less than 3 months of age. Of these eight patients, the length of the kidneys in five children (63%) was normal. In the 35 patients older than 3 months of age, kidney size was enlarged.</p><p id="para140" class="elsevierStylePara elsevierViewall">Beyond 12 months of age, kidney growth accelerated (<a class="elsevierStyleCrossRef" href="#fig4">Figure 4</a>); renal growth of patients older than 12 months of age was statistically significant (p=0.03). In patients younger than 12 months of age, kidney growth was not significantly different (p=0.05) for patients with BWS versus control patients.</p><p id="para150" class="elsevierStylePara elsevierViewall">When the estimated growth charts for kidney length were superimposed on the kidney lengths of normal age-matched controls drawn from Rosenbaum et al,<a class="elsevierStyleCrossRef" href="#bib6">6</a> the differences in the length of the kidneys between controls and patients with BWS were borderline significant (p=0.05) for patients younger than 1 year of age and highly statistically significant (p=0.003) for patients older than 1 year of age (<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>).</p><p id="para160" class="elsevierStylePara elsevierViewall">However, the kidney sizes for patients with BWS across most other age categories were less than one standard deviation larger than those of the age-matched control children (<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>).</p><p id="para170" class="elsevierStylePara elsevierViewall">In our study, nine patients presented Wilms tumors at the time of their diagnosis. Although we had no information about the baseline size of these patients’ kidneys, at the time of the study, their kidneys were more han two standard deviations larger than expected for their ages. A comparison of the findings of the 1998 study of DeBaun et al<a class="elsevierStyleCrossRef" href="#bib5">5</a> with our results confirmed that, if the lengths of the kidneys of patients with BWS were more than two standard deviations greater than those of their age-matched controls, these patients would be at greater risk of developing Wilms tumors in the future.</p></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle100">DISCUSSION</span><p id="para180" class="elsevierStylePara elsevierViewall">Our study offers a practical and standardized renal growth chart for the evaluation of kidney size in children with BWS. Based on extensive experience from previous reports,<a class="elsevierStyleCrossRefs" href="#bib7">7–9</a> kidney length is considered the best assessment tool of the size and growth of the kidneys. Our results for 43 children with BWS revealed a linear relationship between the length of the kidney and patient age. Furthermore, the lengths of both kidneys were above the mean control values beginning at 12 months of age and increased linearly over time thereafter. This finding is consistent with that of another study<a class="elsevierStyleCrossRef" href="#bib10">10</a> that used sonography to determine the size of normal children’s kidneys.</p></span><span id="cesec50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle110">CONCLUSION</span><p id="para190" class="elsevierStylePara elsevierViewall">Our study offers a practical, simple renal growth chart that is a reasonable, sensitive method for evaluation of kidney size in children with BWS. Our renal growth chart can be used to determine objectively the expected size of the kidneys of patients with BWS. In future, this chart could be used to help develop risk estimates for Wilms tumors and to support better health outcomes in these children.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:7 [ 0 => array:2 [ "identificador" => "xpalclavsec1584659" "titulo" => "KEYWORDS" ] 1 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 2 => array:2 [ "identificador" => "cesec20" "titulo" => "MATERIALS AND METHODS" ] 3 => array:2 [ "identificador" => "cesec30" "titulo" => "RESULTS" ] 4 => array:2 [ "identificador" => "cesec40" "titulo" => "DISCUSSION" ] 5 => array:2 [ "identificador" => "cesec50" "titulo" => "CONCLUSION" ] 6 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-09-22" "fechaAceptado" => "2008-09-29" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1584659" "palabras" => array:5 [ 0 => "Beckwith-Wiedemann syndrome" 1 => "Renal length" 2 => "Wilms Tumor" 3 => "Renal nomogram" 4 => "Practical chart" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">BACKGROUND:</span><p id="spara60" class="elsevierStyleSimplePara elsevierViewall">Beckwith-Wiedemann syndrome is a disorder of somatic overgrowth. Evidence of kidney overgrowth is a diagnostic criterion that may be used to help identify those patients who are at the greatest risk of developing Wilms tumors. In such subjects, kidney size is typically larger than that of age-matched normal controls.</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">OBJECTIVE:</span><p id="spara70" class="elsevierStyleSimplePara elsevierViewall">The purpose of our study was to generate a nomogram that could be used to measure renal dimensions in children with Beckwith-Wiedemann syndrome in a clinical setting.</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">MATERIALS & METHODS:</span><p id="spara80" class="elsevierStyleSimplePara elsevierViewall">All of the Beckwith-Wiedemann syndrome patients followed at our institution from 1996 to 2004 were eligible for inclusion in our study. Renal length was measured with a curvilinear transducer and with the patient supine. Renal lengths were measured for both kidneys using real-time ultrasound for all patients. Their data were compared with those of age-matched controls reported in the 1984 study by Rosenbaum et al.</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">RESULTS:</span><p id="spara90" class="elsevierStyleSimplePara elsevierViewall">Ninety-six children with Beckwith-Wiedemann syndrome were followed from 1996 to 2004. Forty-three of these patients met our criteria for inclusion in the study: 28 girls (65%) and 15 boys (35%). We identified a linear relationship between kidney length and patient age. No statistically significant differences in renal length were found between boys and girls (p=0.2153) or between the kidneys on either side of the body (p=0.9613).</p></span> <span id="ceabs50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle50">CONCLUSION:</span><p id="spara100" class="elsevierStyleSimplePara elsevierViewall">Our study provides a practical, simple renal growth chart that offers a reasonable, sensitive method for evaluating kidney size in children with Beckwith-Wiedemann syndrome.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "ceabs10" "titulo" => "BACKGROUND:" ] 1 => array:2 [ "identificador" => "ceabs20" "titulo" => "OBJECTIVE:" ] 2 => array:2 [ "identificador" => "ceabs30" "titulo" => "MATERIALS & METHODS:" ] 3 => array:2 [ "identificador" => "ceabs40" "titulo" => "RESULTS:" ] 4 => array:2 [ "identificador" => "ceabs50" "titulo" => "CONCLUSION:" ] ] ] ] "multimedia" => array:5 [ 0 => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1-" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 472 "Ancho" => 654 "Tamanyo" => 46730 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Renal growth curves for normal control (blue line) age-matched population, as published by Rosenbaum et al.<a class="elsevierStyleCrossRef" href="#bib6">6</a>, and patients with Beckwith-Wiedemann syndrome (BWS; black line). Renal growth is parallel and renal length increases continuously at an approximately constant rate above normal that is never above two standard deviations</p>" ] ] 1 => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2-" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 470 "Ancho" => 655 "Tamanyo" => 32035 ] ] "descripcion" => array:1 [ "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Renal length and growth of the right kidney of patients with Beckwith-Wiedemann syndrome (BWS)</p>" ] ] 2 => array:7 [ "identificador" => "fig3" "etiqueta" => "Figure 3-" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 470 "Ancho" => 659 "Tamanyo" => 31833 ] ] "descripcion" => array:1 [ "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Renal length and growth of the left kidney in patients with Beckwith-Wiedemann syndrome (BWS)</p>" ] ] 3 => array:7 [ "identificador" => "fig4" "etiqueta" => "Figure 4-" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 488 "Ancho" => 683 "Tamanyo" => 34806 ] ] "descripcion" => array:1 [ "en" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">Growth pattern of kidneys (right and left) for patients with Beckwith-Wiedemann syndrome (BWS). There was no significant difference in the patterns of growth for the right and left kidneys</p>" ] ] 4 => array:7 [ "identificador" => "tbl1" "etiqueta" => "Table 1-" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "<p id="tfn1" class="elsevierStyleSimplePara elsevierViewall">Note. — No.= Number of measurements, since some patients were assessed more than once. SD=Standard Deviation.</p>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="4" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Length of Kidneys (cm)</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Children with BWS</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Normal Children<a class="elsevierStyleCrossRef" href="#tfn2">*</a></th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Age interval \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">No. (n=43) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Mean (SD) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">No. (n=43) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Mean (SD) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">p-Value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 days to 4 mo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.73 (0.56) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">54 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.28 (0.66) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.48806 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 to 8 mo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.35 (0.66) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.15 (0.67) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.76564 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 mo 1 day to 1 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.69 (0.61) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.23 (0.63) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.46343 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 y 1 day to 2 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.06 (0.60) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.65 (0.54) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.47972 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 y 1 day to 3 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.57 (0.53) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.36 (0.54) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.69462 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 y 1 day to 4 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.87 (0.58) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.36 (0.64) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.40027 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 y 1 day to 5 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">58 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.15 (0.48) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.87 (0.50) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.56625 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 y 1 day to 6 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.52 (0.51) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.09 (0.54) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.41112 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 y 1 day to 7 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.66 (0.56) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.83 (0.72) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.17597 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 y 1 day to 8 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.79 (0.65) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.33 (0.51) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.43919 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 y 1 day to 9 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.00 (0.66) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.90 (0.88) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.90277 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 y 1 day to 10 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.10 (1.03) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.20 (0.90) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.91583 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 y 1 day to 11 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.12 (0.53) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.17 (0.82) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.22533 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 y 1 day to 12 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.11 (0.64) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.60 (0.64) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.43248 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 y 1 day to 13 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.05 (0.83) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.42 (0.87) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.67396 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 y 1 day to 14 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.50 (1.26) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.79 (0.75) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.40917 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tfn2" "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara" id="cenpara10">Normal kidney length from Rosenbaum et al <a class="elsevierStyleCrossRef" href="#bib6">6</a></p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara50" class="elsevierStyleSimplePara elsevierViewall">Mean renal lengths for patients with Beckwith-Wiedemann syndrome and age-matched controls</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Beckwith JB. Extreme cytomegaly of the adrenal fetal cortex, omphalocele, hyperplasia of kidneys and pancreas, and Leydig-cell hyperplasia: Another syndrome? Abstract, Western Society for Pediatric Research. Los Angeles, November 11, 1963" ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Complexe malformatif familial avec hernia ombilicale et macroglossia: un syndrome nouveau?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ H Wiedemann \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Genet Hum" "fecha" => "1964" "volumen" => "13" "paginaInicial" => "223" "paginaFinal" => "232" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14231762" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Wiedemann-Beckwith syndrome: further prenatal characterization of the condition" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ O Reish \n \t\t\t\t\t\t\t\t """ 1 => """ I Lerer \n \t\t\t\t\t\t\t\t """ 2 => """ A Amiel \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ajmg.10143" "Revista" => array:6 [ "tituloSerie" => "Am J Med Genet" "fecha" => "2002" "volumen" => "107" "paginaInicial" => "209" "paginaFinal" => "213" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11807901" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Beckwith-Wiedemann syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ R Weksberg \n \t\t\t\t\t\t\t\t """ 1 => """ C Shuman \n \t\t\t\t\t\t\t\t """ 2 => """ AC Smith \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med Genet C Semin Med Genet" "fecha" => "2005" "volumen" => "137" "numero" => "1" "paginaInicial" => "12" "paginaFinal" => "23" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nephromegaly in infancy and early childhood: a risk factor for Wilms tumor in Beckwith-Wiedemann syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ MR DeBaun \n \t\t\t\t\t\t\t\t """ 1 => """ MJ Siegel \n \t\t\t\t\t\t\t\t """ 2 => """ PL Choyke \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0022-3476(98)70009-5" "Revista" => array:7 [ "tituloSerie" => "J Pediatr" "fecha" => "1998" "volumen" => "132" "numero" => "3 Pt 1" "paginaInicial" => "401" "paginaFinal" => "404" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9544890" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sonographic assessment of renal length in normal children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ DM Rosenbaum \n \t\t\t\t\t\t\t\t """ 1 => """ E Korngold \n \t\t\t\t\t\t\t\t """ 2 => """ RL Teele \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2214/ajr.142.3.467" "Revista" => array:6 [ "tituloSerie" => "AJR" "fecha" => "1984" "volumen" => "142" "paginaInicial" => "467" "paginaFinal" => "469" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6607625" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Kidney size in children. A method of assessment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ O Eklof \n \t\t\t\t\t\t\t\t """ 1 => """ H Ringertz \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Radiol Diagn" "fecha" => "1976" "volumen" => "17" "numero" => "5A" "paginaInicial" => "617" "paginaFinal" => "625" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Measuring the kidneys-practical applications using a growth and hypertrophy chart" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ RL Lebowitz \n \t\t\t\t\t\t\t\t """ 1 => """ T Hopkins \n \t\t\t\t\t\t\t\t """ 2 => """ AH Colodny \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/BF00978818" "Revista" => array:6 [ "tituloSerie" => "Pediatr Radiol" "fecha" => "1975" "volumen" => "4" "paginaInicial" => "37" "paginaFinal" => "42" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1233453" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Kidney length correlated with age: normal values in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ G Currarino \n \t\t\t\t\t\t\t\t """ 1 => """ B Williams \n \t\t\t\t\t\t\t\t """ 2 => """ K Dana \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1148/radiology.150.3.6695070" "Revista" => array:6 [ "tituloSerie" => "Radiology" "fecha" => "1984" "volumen" => "150" "paginaInicial" => "703" "paginaFinal" => "704" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6695070" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Kidney size in childhood. Sonographical growth charts for kidney length and volume" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ E Dinkel \n \t\t\t\t\t\t\t\t """ 1 => """ M Ertel \n \t\t\t\t\t\t\t\t """ 2 => """ M Dittrich \n \t\t\t\t\t\t\t\t """ 3 => """ H Peters \n \t\t\t\t\t\t\t\t """ 4 => """ K Berres \n \t\t\t\t\t\t\t\t """ 5 => """ H Schulte-Wissermann \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/BF02387851" "Revista" => array:6 [ "tituloSerie" => "Pediatr Radiol" "fecha" => "1985" "volumen" => "15" "paginaInicial" => "38" "paginaFinal" => "43" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3881724" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/18075932/0000006400000001/v1_202212060707/S1807593222027041/v1_202212060707/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/18075932/0000006400000001/v1_202212060707/S1807593222027041/v1_202212060707/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222027041?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 1 | 7 |
| 2024 October | 22 | 26 | 48 |
| 2024 September | 22 | 17 | 39 |
| 2024 August | 24 | 19 | 43 |
| 2024 July | 29 | 14 | 43 |
| 2024 June | 19 | 17 | 36 |
| 2024 May | 31 | 16 | 47 |
| 2024 April | 25 | 12 | 37 |
| 2024 March | 21 | 17 | 38 |
| 2024 February | 25 | 7 | 32 |
| 2024 January | 25 | 16 | 41 |
| 2023 December | 11 | 14 | 25 |
| 2023 November | 9 | 18 | 27 |
| 2023 October | 13 | 19 | 32 |
| 2023 September | 6 | 8 | 14 |
| 2023 August | 5 | 8 | 13 |
| 2023 July | 2 | 16 | 18 |
| 2023 June | 21 | 2 | 23 |
| 2023 May | 10 | 2 | 12 |
| 2023 April | 32 | 1 | 33 |
| 2023 March | 24 | 1 | 25 |
| 2023 February | 18 | 1 | 19 |
| 2023 January | 2 | 3 | 5 |
| 2022 December | 8 | 0 | 8 |
Show all