The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility

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"nombre" => "Mustafa" "apellidos" => "Tuncer" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S180759322202885X?idApp=UINPBA00004N" "url" => "/18075932/0000006500000011/v1_202212010805/S180759322202885X/v1_202212010805/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "CLINICAL SCIENCE" "titulo" => "The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1073" "paginaFinal" => "1076" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Cristiane Gimenes, Bianca Bianco, Fernanda Abani Mafra, Victor Rosset, Denise Maria Christofolini, Caio Parente Barbosa" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Cristiane" "apellidos" => "Gimenes" ] 1 => array:4 [ "nombre" => "Bianca" "apellidos" => "Bianco" "email" => array:1 [ 0 => "bianca.bianco@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "c1-cln_65p1073" ] ] ] 2 => array:2 [ "nombre" => "Fernanda Abani" "apellidos" => "Mafra" ] 3 => array:2 [ "nombre" => "Victor" "apellidos" => "Rosset" ] 4 => array:2 [ "nombre" => "Denise Maria" "apellidos" => "Christofolini" ] 5 => array:2 [ "nombre" => "Caio Parente" "apellidos" => "Barbosa" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Gynecology and Obstetrics Department, Faculdade de Medicina do ABC, Santo André, São Paulo, Brazil" "identificador" => "af1-cln_65p1073" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "c1-cln_65p1073" "etiqueta" => "*" "correspondencia" => "Tel.: 55 11 4438-7299 end_of_the_skype_highlighting" ] ] ] ] "textoCompleto" => "INTRODUCTIONEndometriosis is a common disease defined as the growth of endometrial tissue outside the uterine cavity and results in a vast array of gynecological problems including dyspareunia, dysmenorrhea, pelvic pain and infertility.<a class="elsevierStyleCrossRefs" href="#bib1">1,2</a> Several studies have revealed a large number of genetic markers related to immune, neuroendocrine and reproductive functions present in high frequency among patients with endometriosis, indicating associations between the development of endometriosis and genetic polymorphisms.<a class="elsevierStyleCrossRefs" href="#bib3">3-6</a>Progesterone is a potent antagonist of estrogen-induced proliferation in the endometrium and may play a pivotal role in the pathogenesis of endometriosis. The human progesterone receptor gene is located at chromosome 11q22-23 and has two isoforms that modulate the biological action of progesterone: isoform A, which is capable of inhibiting the activation of the estrogen receptors, and isoform B, which has the capacity to activate the estrogen receptors.<a class="elsevierStyleCrossRef" href="#bib7">7</a> Several polymorphisms have been described for this gene, among which one stands out: a polymorphism named PROGINS, which arises due to the insertion of an Alu element into intron G between exons 7 and 8 of isoform A of the PR gene, resulting in an increase of 306 bp in the gene product.<a class="elsevierStyleCrossRef" href="#bib8">8</a>Wieser et al.<a class="elsevierStyleCrossRef" href="#bib9">9</a> studied 95 women with endometriosis and 107 women without endometriosis and concluded that the PROGINS polymorphism is associated with susceptibility to endometriosis. Similarly, Lattuada et al.<a class="elsevierStyleCrossRef" href="#bib10">10</a> studied the PROGINS polymorphism in 131 women with endometriosis and a control group of 127 women and confirmed the relationship between this polymorphism and endometriosis. Similar results were also obtained by Carvalho et al.<a class="elsevierStyleCrossRef" href="#bib11">11</a> On the other hand, Govindan et al.<a class="elsevierStyleCrossRef" href="#bib12">12</a> tested 445 Indian women: 100 had endometriosis, 80 had uterine fibrosis, 157 had breast cancer, and 108 served as a control group. These authors concluded that the PROGINS polymorphism can be considered a risk marker for breast cancer but not for endometriosis or uterine fibrosis.Thus, the objective of the present study was to determine the frequency of the progesterone receptor gene polymorphism PROGINS in women with endometriosis-associated infertility or idiopathic infertility and in controls.MATERIAL AND METHODSPatientsAmong the patients of the Human Reproduction Service of the Faculdade de Medicina do ABC (FMABC), 148 patients with endometriosis-associated infertility (mean age: 34.4 ± 4.2 years) diagnosed by laparoscopy and classified by histological criteria according to the American Society for Reproductive Medicine<a class="elsevierStyleCrossRef" href="#bib13">13</a> and 50 idiopathic infertile women (mean age: 35.5 ± 3.1 y) were selected. In the endometriosis group, 48.0% (71/148) had minimal/mild endometriosis, and 52.0% (77/148) had moderate/severe endometriosis. For the control group, 179 fertile women (mean age: 39.7 ± 4.8 years) who had undergone tubal ligation, which allowed confirmation of the absence of endometriosis, were selected from the Family Planning Outpatient Clinic of the FMABC.The cause of infertility was investigated according to the minimum propaedeutic of the infertile couple: hormonal and biochemistry profiles, serum testing, sexually transmitted disease investigations, imaging examinations, investigations of genetic and/or immunological abnormalities, hysterosalpingography, hysteroscopy, laparoscopy (laparoscopy was performed in all women up to 36 years old and in patients over 36 years old when there were symptoms or imaging examinations abnormalities) and seminal analysis. In the absence of abnormalities in any of these exams, the infertility was considered idiopathic. Patients with endometriosis who did not achieve pregnancy after at least six natural or induced cycles following laparoscopy were considered infertile. All women whose partner had masculine factors involved with the infertility were excluded from the study.Clinical data and peripheral blood samples were collected only after explaining the objectives of the study and obtaining a signed informed consent form, as approved by the local Research Ethics Committee (CEP FMABC No. 293/2007).MethodsDNA ExtractionPeripheral blood was collect from each patient and control in an EDTA-containing tube. Genomic DNA was extracted from lymphocytes in the peripheral blood using an illustra blood genomicPrep Mini Spin Kit, according to the manufacturer's instructions (GE Healthcare Life Sciences, USA).PCRMolecular analysis of the PROGINS progesterone receptor gene polymorphism was performed according to the protocol of Wieser et al.<a class="elsevierStyleCrossRef" href="#bib9">9</a> with modifications. The primers used were 5′-GGC AGA AAG CAA AAT AAA AAG A-3′ (forward) and 5′-AAA GTA TTT TCT TGC TAA ATG TC-3′ (reverse).The PCR reaction was carried out in a final volume of 25 µl, containing 1X buffer, 2.5 mM MgCl2, 0.1 mM of each dNTP, 50 nM of each primer, 1 U of Taq Polymerase (Invitrogen), and 200 ng of DNA. Amplification was performed with an initial denaturation step at 95 °C for 7 min, followed by 35 cycles of denaturation at 95 °C for 45 sec, annealing at 50 °C for 1 min, and extension at 72 °C for 1 min and a final extension step at 72 °C for 7 min. The amplification product was visualized in a 1% agarose gel under UV light.The PCR product presented a single band of 149 bp in the homozygous individuals without the mutation, designated as P1P1. The presence of one 149-bp and one 455-bp band indicated heterozygous individuals, who have one allele without the mutation and one allele with the mutation; these individual were designated as P1P2. The presence of a single 455-bp band indicated individuals with the mutation in both alleles, and these individuals were designated as P2P2.Statistical analysisAllele and genotype frequencies were compared between groups using the χ2-test or the Fisher's exact test. All p-values were two-tailed, and 95% confidence intervals (CIs) were calculated. A p-value < 0.05 was considered statistically significant.RESULTSThe genotype and allele frequencies of the PROGINS polymorphism in patients with endometriosis-associated infertility or idiopathic infertile patients and in the control group are summarized in <a class="elsevierStyleCrossRef" href="#t1-cln_65p1073">Table 1</a>.<elsevierMultimedia ident="t1-cln_65p1073"></elsevierMultimedia>The frequencies of genotypes P1P1, P1P2 and P2P2 of the PROGINS polymorphism in the patients with endometriosis-associated infertility were 93.9% (139/148), 5.4% (8/148) and 0.7% (1/148), respectively (p = 0.2101). Among the women with minimal/mild endometriosis, 94.4% (67/71) presented the normal homozygous genotype P1P1, 4.2% (3/71) had the heterozygous genotype P1P2, and 1.4% (1/71) showed the mutated homozygous genotype P2P2 (p = 0.2725). In the patients with moderate/severe endometriosis, the frequencies of genotypes P1P1, P1P2 and P2P2 were 93.5% (72/77), 6.5% (5/77), and 0%, respectively (p = 0.3679). In idiopathic infertile women, the genotypes P1P1, P1P2 and P2P2 were observed in 86.0% (43/50), 14.0% (7/50) and 0% of women, respectively (p = 0.8146). In the control group, 88.3% (158/179) presented the normal homozygous genotype P1P1, 10.6% showed (19/179) the heterozygous genotype P1P2, and 1.1% (2/179) had the homozygous mutated genotype (<a class="elsevierStyleCrossRef" href="#t1-cln_65p1073">Table 1</a>).Considering the alleles, allele P1 was present in 96.6% of patients with endometriosis-associated infertility, in 96.5% of women with minimal/mild endometriosis, in 96.8% patients with moderate/severe endometriosis, in 93.0% of idiopathic infertile women and in 93.6% of the control group. Allele P2, on the other hand, was present in 3.4% of patients with endometriosis-associated infertility (p = 0.1117, OR = 0.51, 95% CI = 0.24-1.09), in 3.5% of women with minimal/mild endometriosis (p = 0.2899, OR = 0.53, 95% CI = 0.20-1.43), in 3.2% patients with moderate/severe endometriosis (p = 0.2161, OR = 0.49, 95% CI = 0.18-1.31), in 7.0% of idiopathic infertile women (p = 1.0, OR = 1.10, 95% CI = 0.46-2.63) and in 6.4% of the control group.The power calculations for the groups of women with endometriosis-associated infertility and idiopathic infertility were 0.80, α = 0.05, and <0.50, α = 0.05, respectively.DISCUSSIONThe PROGINS polymorphism produces a decrease in the stability of the progesterone receptor gene, causing the receptor to lose its capacity to inhibit the activation of the estrogen receptors. This in turn results in an inadequate control of these receptors, thus rendering the endometrium more vulnerable to the action of estrogen. It is believed that isoform A can lead to increased expression of isoform B (which is responsible for the activation of the estrogen receptors) when it includes the PROGINS polymorphism, thereby contributing to a higher oncogenic action of this polymorphism.<a class="elsevierStyleCrossRef" href="#bib14">14</a> Progesterone is involved in the regulation of extracellular matrix metalloproteinases, stimulating the inhibiting factors of these enzymes; it also acts on the expression of angiogenic factors and on cell cycle-regulating factors. Moreover, D'Amora et al.<a class="elsevierStyleCrossRef" href="#bib15">15</a> observed that PROGINS variants may influence cell proliferation, viability, and apoptosis in endometrial cell metabolism.Wieser et al.,<a class="elsevierStyleCrossRef" href="#bib9">9</a> Lattuada et al.,<a class="elsevierStyleCrossRef" href="#bib10">10</a> and Carvalho et al.<a class="elsevierStyleCrossRef" href="#bib11">11</a> demonstrated a significant correlation between the PROGINS polymorphism and endometriosis. On the other hand, Govidan et al.<a class="elsevierStyleCrossRef" href="#bib12">12</a> concluded that the PROGINS polymorphism can be considered a risk marker for breast cancer but not for endometriosis or uterine fibrosis. Additionally, van Kaam et al.<a class="elsevierStyleCrossRef" href="#bib16">16</a> studied 72 women with endometriosis, 40 women with adenomyosis in the uterine wall, 102 gynecological patients without symptomatic endometriosis and 93 healthy females and concluded that the PROGINS polymorphism does not seem to modify the risk of deep-infiltrating endometriosis. In the present study, the PROGINS polymorphism was present in 6.1% of the patients with endometriosis-associated infertility and in 11.7% of the women in the control group (p = 0.2101). When we studied the patients with stage I/II or stage III/IV endometriosis separately, no statistical difference was found between groups (p = 0.2725 and p = 0.3679, respectively). This finding suggests that the PROGINS polymorphism is not involved in the genesis of the disease in the population studied (<a class="elsevierStyleCrossRef" href="#t2-cln_65p1073">Table 2</a>).<elsevierMultimedia ident="t2-cln_65p1073"></elsevierMultimedia>Most of the published studies regarding endometriosis have used heterogeneous control groups, such as healthy men and women,<a class="elsevierStyleCrossRef" href="#bib17">17</a> newborns,<a class="elsevierStyleCrossRef" href="#bib18">18</a> umbilical cord blood<a class="elsevierStyleCrossRef" href="#bib19">19</a> and menopausal women.<a class="elsevierStyleCrossRef" href="#bib11">11</a> However, the absence of symptomatology in women does not exclude endometriosis, given that 16% of the patients with endometriosis are fertile and asymptomatic;<a class="elsevierStyleCrossRef" href="#bib20">20</a> when analyzing newborns and cord blood, it is possible that the subjects will develop the disease in the future; and menopause itself produces regression of the disease in women who may be asymptomatic.Our control group was carefully selected among fertile and non-menopausal women who had undergone tubal ligation for family planning reasons and who had no sign of endometriosis in their clinical history. Moreover, the surgeon was able to observe while performing the ligation that there were no foci of endometriosis in these women. This rigorous selection process of the control group may be responsible for the high level of significance of the results obtained.Clinically, one of the primary concerns regarding endometriosis is its propensity to cause infertility. It is currently estimated that 25% to 50% of women with endometriosis are infertile and that 25% to 30% of all infertile women have endometriotic lesions as the only identifiable cause of their infertility.<a class="elsevierStyleCrossRefs" href="#bib1">1,2</a> The association between endometriosis and infertility is well established, but the mechanisms responsible for these effects are unknown. Several hypotheses have been proposed to explain how endometriosis causes infertility: 1) pelvic factors, which include adhesions, distort pelvic anatomy,<a class="elsevierStyleCrossRef" href="#bib21">21</a> and alter peritoneal function;<a class="elsevierStyleCrossRef" href="#bib22">22</a> 2) ovarian factors that stem from endocrine and ovulatory disorders lead to oocyte and embryonic alteration;<a class="elsevierStyleCrossRef" href="#bib23">23</a> and 3) uterine factors cause impaired implantation.<a class="elsevierStyleCrossRef" href="#bib24">24</a> Pisarska et al.<a class="elsevierStyleCrossRef" href="#bib25">25</a> found an increase in the prevalence of PROGINS mutations among 26 women with the diagnosis of unexplained infertility compared to 28 control women (42% vs. 14%); however, in the current study, the PROGINS polymorphism was not associated with infertility (14.0% vs. 11.7%). Our results point to no association between idiopathic infertility and the PROGINS polymorphism; however, the power calculation of the sample was low, suggesting that a larger sample is needed.It is important to keep in mind that the study was performed in a special group of patients who underwent surgery via video laparoscopy and, after surgery, were exposed for at least twelve months to the possibility of pregnancy, had no male factor involved in the causes of infertility and, nevertheless, did not achieve pregnancy.CONCLUSIONIn conclusion, our data suggest that PROGINS is not related either to endometriosis-associated infertility or to idiopathic infertility in the population studied. However, further studies with much larger samples are needed to confirm the results for the idiopathic infertily group." "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:2 [ "identificador" => "xpalclavsec1581402" "titulo" => "KEYWORDS" ] 1 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 2 => array:3 [ "identificador" => "cesec20" "titulo" => "MATERIAL AND METHODS" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "cesec30" "titulo" => "Patients" ] 1 => array:3 [ "identificador" => "cesec40" "titulo" => "Methods" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "cesec50" "titulo" => "DNA Extraction" ] 1 => array:2 [ "identificador" => "cesec60" "titulo" => "PCR" ] 2 => array:2 [ "identificador" => "cesec70" "titulo" => "Statistical analysis" ] ] ] ] ] 3 => array:2 [ "identificador" => "cesec80" "titulo" => "RESULTS" ] 4 => array:2 [ "identificador" => "cesec90" "titulo" => "DISCUSSION" ] 5 => array:2 [ "identificador" => "cesec100" "titulo" => "CONCLUSION" ] 6 => array:2 [ "identificador" => "xack638834" "titulo" => "ACKNOWLEDGMENTS" ] 7 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-05-17" "fechaAceptado" => "2010-08-02" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1581402" "palabras" => array:5 [ 0 => "endometriosis" 1 => "polymorphism" 2 => "PROGINS" 3 => "progesterone receptor gene" 4 => "infertility" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "OBJECTIVE:This study aimed to determine the frequency of the PROGINS polymorphism in women with endometriosis-associated infertility, in infertile women without endometriosis and in controls. INTRODUCTION:The human progesterone receptor gene has two isoforms that modulate the biological action of progesterone: isoform A, which is capable of inhibiting the activation of the estrogen receptors, and isoform B, which has the capacity to activate the estrogen receptors. Several polymorphisms have been described for this gene, among which one stands out: a polymorphism named PROGINS, which has been speculated to be related to the genesis of endometriosis by several studies with conflicting results. METHODS:This was a prospective study that included 148 patients with endometriosis-associated infertility, 50 idiopathic infertile patients and 179 fertile women as controls. The PROGINS polymorphism was studied by PCR. RESULTS:Genotypes P1P1, P1P2 and P2P2 (P2 representing the PROGINS polymorphism) of the progesterone receptor gene presented frequencies of 93.9%, 5.4% and 0.7%, respectively, in the women with endometriosis-associated infertility (p = 0.2101, OR = 0.51, 95% CI = 0.24-1.09); 94.4%, 4.2% and 1.4%, respectively, in the patients with minimal/mild endometriosis (p = 0.2725, OR = 0.53, 95% CI = 0.20-1.43); 93.5%, 6.5% and 0%, respectively, among the patients with moderate/severe endometriosis (p = 0.3679, OR = 0.49, 95% CI = 0.18-1.31); 86.0%, 14.0% and 0%, respectively, in idiopathic infertile women (p = 0.8146, OR = 1.10, 95% CI = 0.46-2.63); and 88.3%, 10.6% and 1.1%, respectively, in the control group. CONCLUSION:The data suggest that PROGINS is not related either to endometriosis-associated infertility or to idiopathic infertility in the population studied." "secciones" => array:5 [ 0 => array:2 [ "identificador" => "ceabs10" "titulo" => "OBJECTIVE:" ] 1 => array:2 [ "identificador" => "ceabs20" "titulo" => "INTRODUCTION:" ] 2 => array:2 [ "identificador" => "ceabs30" "titulo" => "METHODS:" ] 3 => array:2 [ "identificador" => "ceabs40" "titulo" => "RESULTS:" ] 4 => array:2 [ "identificador" => "ceabs50" "titulo" => "CONCLUSION:" ] ] ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "t1-cln_65p1073" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "OR = odds ratio CI = confidence interval" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="bottom" scope="col">Population studied \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col">n \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="3" align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">PROGINS genotypes</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col">p values \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">Alleles</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col">p values \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col">OR (95% CI) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">P1P1 (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">P1P2 (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">P2P2 (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">P1 (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">P2 (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Endometriosis-associated infertility patients \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">148 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">139 (93.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">8 (5.40) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1 (0.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.2101 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">286 (96.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">10 (3.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.1117 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.51 (0.24-1.09) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Minimal/mild endometriosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">71 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">67 (94.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">3 (4.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1 (1.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.2725 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">137 (96.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">5 (3.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.2899 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.53 (0.20-1.43) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Moderate/severe endometriosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">77 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">72 (93.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">5 (6.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0 (0.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.3679 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">149 (96.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">5 (3.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.2161 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.49 (0.18-1.31) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Idiopathic infertile patients \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">43 (86.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">7 (14.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0 (0.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.6126 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">93 (93.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">7 (7.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.10 (0.46-2.63) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Controls \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">179 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">158 (88.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">19 (10.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">2 (1.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">335 (93.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">23 (6.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Frequency of genotypes and alleles of the PROGINS progesterone receptor gene polymorphism in patients with endometriosis-associated infertility, idiopathic infertile patients and in controls." ] ] 1 => array:7 [ "identificador" => "t2-cln_65p1073" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Study \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">Population studied \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">Conclusion of the study \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Weiser et al.<a class="elsevierStyleCrossRef" href="#bib8">8</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">95 white women with endometriosis and 107 white women without endometriosis (controls) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">PROGINS appears to be associated with endometriosis in white persons \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Lattuada et al.<a class="elsevierStyleCrossRef" href="#bib9">9</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">131 Italian women affected by endometriosis and 127 Italian women without laparoscopic evidence of the disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">PROGINS polymorphism of the progesterone receptor may be associated with an increased risk of endometriosis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">De Carvalho et al.<a class="elsevierStyleCrossRef" href="#bib10">10</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">121 Women with surgically confirmed endometriosis and 281 controls with normal gynecological exams \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">PROGINS heterozygosis genotype frequencies were shown to be statistically higher in women with endometriosis than in controls \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Govidan et al.<a class="elsevierStyleCrossRef" href="#bib11">11</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">100 Women with endometriosis, 80 women with fibroids and 157 women with breast cancer along with 108 age-matched normal healthy women as controls \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">PROGINS can be considered to be a predisposing risk marker for breast cancer but not for endometriosis or uterine fibroids \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">van Kaam et al.<a class="elsevierStyleCrossRef" href="#bib15">15</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">72 women with endometriosis, 40 with adenomyosis in the uterine wall, 102 gynecological patients without symptomatic endometriosis and 93 healthy females \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">The PROGINS polymorphism does not seem to modify the risk of deep-infiltrating endometriosis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Present study \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">148 women with endometriosis, 50 idiopathic infertile women and 179 fertile women without a history of endometriosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">PROGINS is not related either to endometriosis-associated infertility or to idiopathic infertility in the population studied \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "PROGINS progesterone receptor gene polymorphisms in different studies." ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:25 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endometriosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ LC Giudice \n \t\t\t\t\t\t\t\t """ 1 => """ LC Kao \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(04)17403-5" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2004" "volumen" => "364" "paginaInicial" => "1789" "paginaFinal" => "1799" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15541453" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/S0140-6736(04)17403-5" "WWW" => array:1 [ "link" => "10.1016/S0140-6736(04)17403-5" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The epidemiology of endometriosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ SA Missmer \n \t\t\t\t\t\t\t\t """ 1 => """ DW Cramer \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/s0889-8545(02)00050-5" "Revista" => array:6 [ "tituloSerie" => "Obstet Gynecol Clin North Am" "fecha" => "2003" "volumen" => "30" "paginaInicial" => "1" "paginaFinal" => "19" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12699255" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/s0889-8545(02)00050-5" "WWW" => array:1 [ "link" => "10.1016/S0889-8545(02)00050-5" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "PTPN22 C1858T polymorphism in women with endometriosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ FM Gomes \n \t\t\t\t\t\t\t\t """ 1 => """ B Bianco \n \t\t\t\t\t\t\t\t """ 2 => """ JS Teles \n \t\t\t\t\t\t\t\t """ 3 => """ DM Christofolini \n \t\t\t\t\t\t\t\t """ 4 => """ AM de Souza \n \t\t\t\t\t\t\t\t """ 5 => """ AD Guedes \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1600-0897.2009.00797.x" "Revista" => array:6 [ "tituloSerie" => "Am J Reprod Immunol" "fecha" => "2010" "volumen" => "63" "paginaInicial" => "227" "paginaFinal" => "232" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20070289" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vascular endothelial growth factor gene +405 C/G polymorphism is associated with susceptibility to advanced stage endometriosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ SH Kim \n \t\t\t\t\t\t\t\t """ 1 => """ YM Choi \n \t\t\t\t\t\t\t\t """ 2 => """ SH Choung \n \t\t\t\t\t\t\t\t """ 3 => """ JK Jun \n \t\t\t\t\t\t\t\t """ 4 => """ JG Kim \n \t\t\t\t\t\t\t\t """ 5 => """ SY Moon \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1093/humrep/dei146" "Revista" => array:6 [ "tituloSerie" => "Hum Reprod" "fecha" => "2005" "volumen" => "20" "paginaInicial" => "2904" "paginaFinal" => "2908" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15979997" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1093/humrep/dei146" "WWW" => array:1 [ "link" => "10.1093/humrep/dei146" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "+1730 G/A polymorphism of the estrogen receptor beta gene (ERbeta) may be an important genetic factor predisposing to endometriosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ B Bianco \n \t\t\t\t\t\t\t\t """ 1 => """ DM Christofolini \n \t\t\t\t\t\t\t\t """ 2 => """ FA Mafra \n \t\t\t\t\t\t\t\t """ 3 => """ A Brandes \n \t\t\t\t\t\t\t\t """ 4 => """ K Zulli \n \t\t\t\t\t\t\t\t """ 5 => """ CP Barbosa \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.3109/00016340903297168" "Revista" => array:6 [ "tituloSerie" => "Acta Obstet Gynecol Scand" "fecha" => "2009" "volumen" => "88" "paginaInicial" => "1397" "paginaFinal" => "1401" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19878085" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.3109/00016340903297168" "WWW" => array:1 [ "link" => "10.3109/00016340903297168" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Does gestrinone antagonize the effects of estrogen on endometrial implants upon the peritoneum of rats?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ VL Lobo \n \t\t\t\t\t\t\t\t """ 1 => """ JM Soares Jr \n \t\t\t\t\t\t\t\t """ 2 => """ M de Jesus Simões \n \t\t\t\t\t\t\t\t """ 3 => """ S Simões Rdos \n \t\t\t\t\t\t\t\t """ 4 => """ GR de Lima \n \t\t\t\t\t\t\t\t """ 5 => """ EC Baracat \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1590/s1807-59322008000400019" "Revista" => array:6 [ "tituloSerie" => "Clinics" "fecha" => "2008" "volumen" => "63" "paginaInicial" => "525" "paginaFinal" => "530" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18719766" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1590/s1807-59322008000400019" "WWW" => array:1 [ "link" => "10.1590/S1807-59322008000400019" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human progesterone receptor gene polymorphism PROGINS and risk for breast cancer in Austrian women" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ G Fabjani \n \t\t\t\t\t\t\t\t """ 1 => """ D Tong \n \t\t\t\t\t\t\t\t """ 2 => """ K Czerwenka \n \t\t\t\t\t\t\t\t """ 3 => """ E Schuster \n \t\t\t\t\t\t\t\t """ 4 => """ P Speiser \n \t\t\t\t\t\t\t\t """ 5 => """ S Leodolter \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Breast Cancer Res Treat" "fecha" => "2002" "volumen" => "72" "paginaInicial" => "131" "paginaFinal" => "137" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "10.1023/A:1014813931765" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "PROGINS Alu insertion and human genomic diversity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ CJ Donaldson \n \t\t\t\t\t\t\t\t """ 1 => """ JP Crapanzano \n \t\t\t\t\t\t\t\t """ 2 => """ JC Watson \n \t\t\t\t\t\t\t\t """ 3 => """ EA Levine \n \t\t\t\t\t\t\t\t """ 4 => """ MA Batzer \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0027-5107(02)00015-5" "Revista" => array:6 [ "tituloSerie" => "Mutat Res" "fecha" => "2002" "volumen" => "501" "paginaInicial" => "137" "paginaFinal" => "141" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11934445" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "PROGINS receptor gene polymorphism is associated with endometriosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ F Wieser \n \t\t\t\t\t\t\t\t """ 1 => """ C Schneeberger \n \t\t\t\t\t\t\t\t """ 2 => """ D Tong \n \t\t\t\t\t\t\t\t """ 3 => """ C Tempfer \n \t\t\t\t\t\t\t\t """ 4 => """ JC Huber \n \t\t\t\t\t\t\t\t """ 5 => """ R Wenzl \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/s0015-0282(01)02984-3" "Revista" => array:6 [ "tituloSerie" => "Fertil Steril" "fecha" => "2002" "volumen" => "77" "paginaInicial" => "309" "paginaFinal" => "312" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11821088" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/s0015-0282(01)02984-3" "WWW" => array:1 [ "link" => "10.1016/S0015-0282(01)02984-3" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetics of endometriosis: a role for the progesterone receptor gene polymorphism PROGINS?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ D Lattuada \n \t\t\t\t\t\t\t\t """ 1 => """ E Somigliana \n \t\t\t\t\t\t\t\t """ 2 => """ P Vigano \n \t\t\t\t\t\t\t\t """ 3 => """ M Candiani \n \t\t\t\t\t\t\t\t """ 4 => """ G Pardi \n \t\t\t\t\t\t\t\t """ 5 => """ AM Di Blasio \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Endocrinol" "fecha" => "2004" "volumen" => "61" "paginaInicial" => "190" "paginaFinal" => "194" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "10.1111/j.1365-2265.2004.02076.x" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic polymorphisms of cytochrome P450cl7alpha (CYP17) and progesterone receptor genes (PROGINS) in the assessment of endometriosis risk" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ CV De Carvalho \n \t\t\t\t\t\t\t\t """ 1 => """ NC Nogueira-De-Souza \n \t\t\t\t\t\t\t\t """ 2 => """ AM Costa \n \t\t\t\t\t\t\t\t """ 3 => """ EC Baracat \n \t\t\t\t\t\t\t\t """ 4 => """ MJ Girão \n \t\t\t\t\t\t\t\t """ 5 => """ P D'Amora \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1080/09513590601024707" "Revista" => array:7 [ "tituloSerie" => "Gynecol Endocrinol" "fecha" => "2007" "volumen" => "23" "paginaInicial" => "29" "paginaFinal" => "33" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17484509" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673600025277" "estado" => "S300" "issn" => "01406736" ] ] ] 1 => array:2 [ "doi" => "10.1080/09513590601024707" "WWW" => array:1 [ "link" => "10.1080/09513590601024707" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of progesterone receptor gene polymorphism (PROGINS) with endometriosis, uterine fibroids and breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ S Govindan \n \t\t\t\t\t\t\t\t """ 1 => """ SN Ahmad \n \t\t\t\t\t\t\t\t """ 2 => """ B Vedicherla \n \t\t\t\t\t\t\t\t """ 3 => """ V Kodati \n \t\t\t\t\t\t\t\t """ 4 => """ P Jahan \n \t\t\t\t\t\t\t\t """ 5 => """ KP Rao \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cancer Biomark" "fecha" => "2007" "volumen" => "3" "paginaInicial" => "73" "paginaFinal" => "78" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Revised American Society for Reproductive Medicine classification of endometriosis: 1996" ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0015-0282(97)81391-x" "Revista" => array:6 [ "tituloSerie" => "Fertil Steril" "fecha" => "1997" "volumen" => "67" "paginaInicial" => "817" "paginaFinal" => "821" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9130884" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A genetic mutation in progesterone receptor (PROGINS) leads to an increased risk of non-familial breast and ovarian cancer causing inadequate control of estrogen receptor driven proliferation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ DG Kieback \n \t\t\t\t\t\t\t\t """ 1 => """ XW Tong \n \t\t\t\t\t\t\t\t """ 2 => """ NL Weigel \n \t\t\t\t\t\t\t\t """ 3 => """ IU Agoulnik \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Soc Gynecol Invest" "fecha" => "1998" "volumen" => "5" "numero" => "1 Suppl 1" "paginaInicial" => "40A" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "10.1016/S1071-5576(97)86082-0" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Disrupted cell cycle control in cultured endometrial cells from patients with endometriosis harboring the progesterone receptor polymorphism PROGINS" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ P D'Amora \n \t\t\t\t\t\t\t\t """ 1 => """ TT Maciel \n \t\t\t\t\t\t\t\t """ 2 => """ R Tambellini \n \t\t\t\t\t\t\t\t """ 3 => """ MA Mori \n \t\t\t\t\t\t\t\t """ 4 => """ JB Pesquero \n \t\t\t\t\t\t\t\t """ 5 => """ H Sato \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2353/ajpath.2009.080966" "Revista" => array:6 [ "tituloSerie" => "Am J Pathol" "fecha" => "2009" "volumen" => "175" "paginaInicial" => "215" "paginaFinal" => "224" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19497994" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Progesterone receptor polymorphism +331G/A is associated with a decreased risk of deep infiltrating endometriosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ KJ van Kaam \n \t\t\t\t\t\t\t\t """ 1 => """ A Romano \n \t\t\t\t\t\t\t\t """ 2 => """ JP Schouten \n \t\t\t\t\t\t\t\t """ 3 => """ GA Dunselman \n \t\t\t\t\t\t\t\t """ 4 => """ PG Groothuis \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1093/humrep/del325" "Revista" => array:6 [ "tituloSerie" => "Hum Reprod" "fecha" => "2007" "volumen" => "22" "paginaInicial" => "129" "paginaFinal" => "135" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16920727" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1093/humrep/del325" "WWW" => array:1 [ "link" => "10.1093/humrep/del325" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between PTPN22 and endometriosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ M Ammendola \n \t\t\t\t\t\t\t\t """ 1 => """ N Bottini \n \t\t\t\t\t\t\t\t """ 2 => """ A Pietropolli \n \t\t\t\t\t\t\t\t """ 3 => """ P Saccucci \n \t\t\t\t\t\t\t\t """ 4 => """ F Gloria-Bottini \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.fertnstert.2007.04.008" "Revista" => array:6 [ "tituloSerie" => "Fertil Steril" "fecha" => "2008" "volumen" => "89" "paginaInicial" => "993" "paginaFinal" => "994" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17624340" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.fertnstert.2007.04.008" "WWW" => array:1 [ "link" => "10.1016/j.fertnstert.2007.04.008" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of p53 codon 72 polymorphism with endometriosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ M Ammendola \n \t\t\t\t\t\t\t\t """ 1 => """ F Gloria-Bottini \n \t\t\t\t\t\t\t\t """ 2 => """ F Sesti \n \t\t\t\t\t\t\t\t """ 3 => """ E Piccione \n \t\t\t\t\t\t\t\t """ 4 => """ E Bottini \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.fertnstert.2007.06.051" "Revista" => array:6 [ "tituloSerie" => "Fertil Steril" "fecha" => "2008" "volumen" => "90" "paginaInicial" => "406" "paginaFinal" => "408" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17931634" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.fertnstert.2007.06.051" "WWW" => array:1 [ "link" => "10.1016/j.fertnstert.2007.06.051" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Polymorphisms in the estrogen receptor beta gene but not estrogen receptor alpha gene affect the risk of developing endometriosis in a Japanese population" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ Z Wang \n \t\t\t\t\t\t\t\t """ 1 => """ S Yoshida \n \t\t\t\t\t\t\t\t """ 2 => """ K Negoro \n \t\t\t\t\t\t\t\t """ 3 => """ S Kennedy \n \t\t\t\t\t\t\t\t """ 4 => """ D Barlow \n \t\t\t\t\t\t\t\t """ 5 => """ T Maruo \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Fertil Steril" "fecha" => "2004" "volumen" => "81" "paginaInicial" => "1650" "paginaFinal" => "1656" ] ] 1 => array:1 [ "WWW" => array:1 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CLINICAL SCIENCE

Cristiane Gimenes, Bianca Bianco

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bianca.bianco@hotmail.com

Tel.: 55 11 4438-7299 end_of_the_skype_highlighting

, Fernanda Abani Mafra, Victor Rosset, Denise Maria Christofolini, Caio Parente Barbosa

Gynecology and Obstetrics Department, Faculdade de Medicina do ABC, Santo André, São Paulo, Brazil

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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">Endometriosis is a common disease defined as the growth of endometrial tissue outside the uterine cavity and results in a vast array of gynecological problems including dyspareunia&#44; dysmenorrhea&#44; pelvic pain and infertility&#46;<a class="elsevierStyleCrossRefs" href="#bib1">1&#44;2</a> Several studies have revealed a large number of genetic markers related to immune&#44; neuroendocrine and reproductive functions present in high frequency among patients with endometriosis&#44; indicating associations between the development of endometriosis and genetic polymorphisms&#46;<a class="elsevierStyleCrossRefs" href="#bib3">3-6</a></p><p id="para20" class="elsevierStylePara elsevierViewall">Progesterone is a potent antagonist of estrogen-induced proliferation in the endometrium and may play a pivotal role in the pathogenesis of endometriosis&#46; The human progesterone receptor gene is located at chromosome 11q22-23 and has two isoforms that modulate the biological action of progesterone&#58; isoform A&#44; which is capable of inhibiting the activation of the estrogen receptors&#44; and isoform B&#44; which has the capacity to activate the estrogen receptors&#46;<a class="elsevierStyleCrossRef" href="#bib7">7</a> Several polymorphisms have been described for this gene&#44; among which one stands out&#58; a polymorphism named PROGINS&#44; which arises due to the insertion of an <span class="elsevierStyleItalic">Alu</span> element into intron G between exons 7 and 8 of isoform A of the <span class="elsevierStyleItalic">PR</span> gene&#44; resulting in an increase of 306 bp in the gene product&#46;<a class="elsevierStyleCrossRef" href="#bib8">8</a></p><p id="para30" class="elsevierStylePara elsevierViewall">Wieser et al&#46;<a class="elsevierStyleCrossRef" href="#bib9">9</a> studied 95 women with endometriosis and 107 women without endometriosis and concluded that the PROGINS polymorphism is associated with susceptibility to endometriosis&#46; Similarly&#44; Lattuada et al&#46;<a class="elsevierStyleCrossRef" href="#bib10">10</a> studied the PROGINS polymorphism in 131 women with endometriosis and a control group of 127 women and confirmed the relationship between this polymorphism and endometriosis&#46; Similar results were also obtained by Carvalho et al&#46;<a class="elsevierStyleCrossRef" href="#bib11">11</a> On the other hand&#44; Govindan et al&#46;<a class="elsevierStyleCrossRef" href="#bib12">12</a> tested 445 Indian women&#58; 100 had endometriosis&#44; 80 had uterine fibrosis&#44; 157 had breast cancer&#44; and 108 served as a control group&#46; These authors concluded that the PROGINS polymorphism can be considered a risk marker for breast cancer but not for endometriosis or uterine fibrosis&#46;</p><p id="para40" class="elsevierStylePara elsevierViewall">Thus&#44; the objective of the present study was to determine the frequency of the progesterone receptor gene polymorphism PROGINS in women with endometriosis-associated infertility or idiopathic infertility and in controls&#46;</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">MATERIAL AND METHODS</span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">Patients</span><p id="para50" class="elsevierStylePara elsevierViewall">Among the patients of the Human Reproduction Service of the Faculdade de Medicina do ABC &#40;FMABC&#41;&#44; 148 patients with endometriosis-associated infertility &#40;mean age&#58; 34&#46;4 &#177; 4&#46;2 years&#41; diagnosed by laparoscopy and classified by histological criteria according to the American Society for Reproductive Medicine<a class="elsevierStyleCrossRef" href="#bib13">13</a> and 50 idiopathic infertile women &#40;mean age&#58; 35&#46;5 &#177; 3&#46;1 y&#41; were selected&#46; In the endometriosis group&#44; 48&#46;0&#37; &#40;71&#47;148&#41; had minimal&#47;mild endometriosis&#44; and 52&#46;0&#37; &#40;77&#47;148&#41; had moderate&#47;severe endometriosis&#46; For the control group&#44; 179 fertile women &#40;mean age&#58; 39&#46;7 &#177; 4&#46;8 years&#41; who had undergone tubal ligation&#44; which allowed confirmation of the absence of endometriosis&#44; were selected from the Family Planning Outpatient Clinic of the FMABC&#46;</p><p id="para60" class="elsevierStylePara elsevierViewall">The cause of infertility was investigated according to the minimum propaedeutic of the infertile couple&#58; hormonal and biochemistry profiles&#44; serum testing&#44; sexually transmitted disease investigations&#44; imaging examinations&#44; investigations of genetic and&#47;or immunological abnormalities&#44; hysterosalpingography&#44; hysteroscopy&#44; laparoscopy &#40;laparoscopy was performed in all women up to 36 years old and in patients over 36 years old when there were symptoms or imaging examinations abnormalities&#41; and seminal analysis&#46; In the absence of abnormalities in any of these exams&#44; the infertility was considered idiopathic&#46; Patients with endometriosis who did not achieve pregnancy after at least six natural or induced cycles following laparoscopy were considered infertile&#46; All women whose partner had masculine factors involved with the infertility were excluded from the study&#46;</p><p id="para70" class="elsevierStylePara elsevierViewall">Clinical data and peripheral blood samples were collected only after explaining the objectives of the study and obtaining a signed informed consent form&#44; as approved by the local Research Ethics Committee &#40;CEP FMABC No&#46; 293&#47;2007&#41;&#46;</p></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle100">Methods</span><span id="cesec50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle110">DNA Extraction</span><p id="para80" class="elsevierStylePara elsevierViewall">Peripheral blood was collect from each patient and control in an EDTA-containing tube&#46; Genomic DNA was extracted from lymphocytes in the peripheral blood using an illustra blood genomicPrep Mini Spin Kit&#44; according to the manufacturer&#39;s instructions &#40;GE Healthcare Life Sciences&#44; USA&#41;&#46;</p></span><span id="cesec60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle120">PCR</span><p id="para90" class="elsevierStylePara elsevierViewall">Molecular analysis of the PROGINS progesterone receptor gene polymorphism was performed according to the protocol of Wieser et al&#46;<a class="elsevierStyleCrossRef" href="#bib9">9</a> with modifications&#46; The primers used were 5&#8242;-GGC AGA AAG CAA AAT AAA AAG A-3&#8242; &#40;forward&#41; and 5&#8242;-AAA GTA TTT TCT TGC TAA ATG TC-3&#8242; &#40;reverse&#41;&#46;</p><p id="para100" class="elsevierStylePara elsevierViewall">The PCR reaction was carried out in a final volume of 25 &#181;l&#44; containing 1X buffer&#44; 2&#46;5 mM MgCl<span class="elsevierStyleInf">2&#44;</span> 0&#46;1 mM of each dNTP&#44; 50 nM of each primer&#44; 1 U of Taq Polymerase &#40;Invitrogen&#41;&#44; and 200 ng of DNA&#46; Amplification was performed with an initial denaturation step at 95 &#176;C for 7 min&#44; followed by 35 cycles of denaturation at 95 &#176;C for 45 sec&#44; annealing at 50 &#176;C for 1 min&#44; and extension at 72 &#176;C for 1 min and a final extension step at 72 &#176;C for 7 min&#46; The amplification product was visualized in a 1&#37; agarose gel under UV light&#46;</p><p id="para110" class="elsevierStylePara elsevierViewall">The PCR product presented a single band of 149 bp in the homozygous individuals without the mutation&#44; designated as P1P1&#46; The presence of one 149-bp and one 455-bp band indicated heterozygous individuals&#44; who have one allele without the mutation and one allele with the mutation&#59; these individual were designated as P1P2&#46; The presence of a single 455-bp band indicated individuals with the mutation in both alleles&#44; and these individuals were designated as P2P2&#46;</p></span><span id="cesec70" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle130">Statistical analysis</span><p id="para120" class="elsevierStylePara elsevierViewall">Allele and genotype frequencies were compared between groups using the &#967;<span class="elsevierStyleSup">2</span>-test or the Fisher&#39;s exact test&#46; All <span class="elsevierStyleItalic">p</span>-values were two-tailed&#44; and 95&#37; confidence intervals &#40;CIs&#41; were calculated&#46; A <span class="elsevierStyleItalic">p</span>-value &#60; 0&#46;05 was considered statistically significant&#46;</p></span></span></span><span id="cesec80" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle140">RESULTS</span><p id="para130" class="elsevierStylePara elsevierViewall">The genotype and allele frequencies of the PROGINS polymorphism in patients with endometriosis-associated infertility or idiopathic infertile patients and in the control group are summarized in <a class="elsevierStyleCrossRef" href="#t1-cln_65p1073">Table 1</a>&#46;</p><elsevierMultimedia ident="t1-cln_65p1073"></elsevierMultimedia><p id="para140" class="elsevierStylePara elsevierViewall">The frequencies of genotypes P1P1&#44; P1P2 and P2P2 of the PROGINS polymorphism in the patients with endometriosis-associated infertility were 93&#46;9&#37; &#40;139&#47;148&#41;&#44; 5&#46;4&#37; &#40;8&#47;148&#41; and 0&#46;7&#37; &#40;1&#47;148&#41;&#44; respectively &#40;p &#61; 0&#46;2101&#41;&#46; Among the women with minimal&#47;mild endometriosis&#44; 94&#46;4&#37; &#40;67&#47;71&#41; presented the normal homozygous genotype P1P1&#44; 4&#46;2&#37; &#40;3&#47;71&#41; had the heterozygous genotype P1P2&#44; and 1&#46;4&#37; &#40;1&#47;71&#41; showed the mutated homozygous genotype P2P2 &#40;p &#61; 0&#46;2725&#41;&#46; In the patients with moderate&#47;severe endometriosis&#44; the frequencies of genotypes P1P1&#44; P1P2 and P2P2 were 93&#46;5&#37; &#40;72&#47;77&#41;&#44; 6&#46;5&#37; &#40;5&#47;77&#41;&#44; and 0&#37;&#44; respectively &#40;p &#61; 0&#46;3679&#41;&#46; In idiopathic infertile women&#44; the genotypes P1P1&#44; P1P2 and P2P2 were observed in 86&#46;0&#37; &#40;43&#47;50&#41;&#44; 14&#46;0&#37; &#40;7&#47;50&#41; and 0&#37; of women&#44; respectively &#40;p &#61; 0&#46;8146&#41;&#46; In the control group&#44; 88&#46;3&#37; &#40;158&#47;179&#41; presented the normal homozygous genotype P1P1&#44; 10&#46;6&#37; showed &#40;19&#47;179&#41; the heterozygous genotype P1P2&#44; and 1&#46;1&#37; &#40;2&#47;179&#41; had the homozygous mutated genotype &#40;<a class="elsevierStyleCrossRef" href="#t1-cln_65p1073">Table 1</a>&#41;&#46;</p><p id="para150" class="elsevierStylePara elsevierViewall">Considering the alleles&#44; allele P1 was present in 96&#46;6&#37; of patients with endometriosis-associated infertility&#44; in 96&#46;5&#37; of women with minimal&#47;mild endometriosis&#44; in 96&#46;8&#37; patients with moderate&#47;severe endometriosis&#44; in 93&#46;0&#37; of idiopathic infertile women and in 93&#46;6&#37; of the control group&#46; Allele P2&#44; on the other hand&#44; was present in 3&#46;4&#37; of patients with endometriosis-associated infertility &#40;p &#61; 0&#46;1117&#44; OR &#61; 0&#46;51&#44; 95&#37; CI &#61; 0&#46;24-1&#46;09&#41;&#44; in 3&#46;5&#37; of women with minimal&#47;mild endometriosis &#40;p &#61; 0&#46;2899&#44; OR &#61; 0&#46;53&#44; 95&#37; CI &#61; 0&#46;20-1&#46;43&#41;&#44; in 3&#46;2&#37; patients with moderate&#47;severe endometriosis &#40;p &#61; 0&#46;2161&#44; OR &#61; 0&#46;49&#44; 95&#37; CI &#61; 0&#46;18-1&#46;31&#41;&#44; in 7&#46;0&#37; of idiopathic infertile women &#40;p &#61; 1&#46;0&#44; OR &#61; 1&#46;10&#44; 95&#37; CI &#61; 0&#46;46-2&#46;63&#41; and in 6&#46;4&#37; of the control group&#46;</p><p id="para160" class="elsevierStylePara elsevierViewall">The power calculations for the groups of women with endometriosis-associated infertility and idiopathic infertility were 0&#46;80&#44; &#945; &#61; 0&#46;05&#44; and &#60;0&#46;50&#44; &#945; &#61; 0&#46;05&#44; respectively&#46;</p></span><span id="cesec90" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle150">DISCUSSION</span><p id="para170" class="elsevierStylePara elsevierViewall">The PROGINS polymorphism produces a decrease in the stability of the progesterone receptor gene&#44; causing the receptor to lose its capacity to inhibit the activation of the estrogen receptors&#46; This in turn results in an inadequate control of these receptors&#44; thus rendering the endometrium more vulnerable to the action of estrogen&#46; It is believed that isoform A can lead to increased expression of isoform B &#40;which is responsible for the activation of the estrogen receptors&#41; when it includes the PROGINS polymorphism&#44; thereby contributing to a higher oncogenic action of this polymorphism&#46;<a class="elsevierStyleCrossRef" href="#bib14">14</a> Progesterone is involved in the regulation of extracellular matrix metalloproteinases&#44; stimulating the inhibiting factors of these enzymes&#59; it also acts on the expression of angiogenic factors and on cell cycle-regulating factors&#46; Moreover&#44; D&#39;Amora et al&#46;<a class="elsevierStyleCrossRef" href="#bib15">15</a> observed that PROGINS variants may influence cell proliferation&#44; viability&#44; and apoptosis in endometrial cell metabolism&#46;</p><p id="para180" class="elsevierStylePara elsevierViewall">Wieser et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib9">9</a> Lattuada et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib10">10</a> and Carvalho et al&#46;<a class="elsevierStyleCrossRef" href="#bib11">11</a> demonstrated a significant correlation between the PROGINS polymorphism and endometriosis&#46; On the other hand&#44; Govidan et al&#46;<a class="elsevierStyleCrossRef" href="#bib12">12</a> concluded that the PROGINS polymorphism can be considered a risk marker for breast cancer but not for endometriosis or uterine fibrosis&#46; Additionally&#44; van Kaam et al&#46;<a class="elsevierStyleCrossRef" href="#bib16">16</a> studied 72 women with endometriosis&#44; 40 women with adenomyosis in the uterine wall&#44; 102 gynecological patients without symptomatic endometriosis and 93 healthy females and concluded that the PROGINS polymorphism does not seem to modify the risk of deep-infiltrating endometriosis&#46; In the present study&#44; the PROGINS polymorphism was present in 6&#46;1&#37; of the patients with endometriosis-associated infertility and in 11&#46;7&#37; of the women in the control group &#40;p &#61; 0&#46;2101&#41;&#46; When we studied the patients with stage I&#47;II or stage III&#47;IV endometriosis separately&#44; no statistical difference was found between groups &#40;p &#61; 0&#46;2725 and p &#61; 0&#46;3679&#44; respectively&#41;&#46; This finding suggests that the PROGINS polymorphism is not involved in the genesis of the disease in the population studied &#40;<a class="elsevierStyleCrossRef" href="#t2-cln_65p1073">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="t2-cln_65p1073"></elsevierMultimedia><p id="para190" class="elsevierStylePara elsevierViewall">Most of the published studies regarding endometriosis have used heterogeneous control groups&#44; such as healthy men and women&#44;<a class="elsevierStyleCrossRef" href="#bib17">17</a> newborns&#44;<a class="elsevierStyleCrossRef" href="#bib18">18</a> umbilical cord blood<a class="elsevierStyleCrossRef" href="#bib19">19</a> and menopausal women&#46;<a class="elsevierStyleCrossRef" href="#bib11">11</a> However&#44; the absence of symptomatology in women does not exclude endometriosis&#44; given that 16&#37; of the patients with endometriosis are fertile and asymptomatic&#59;<a class="elsevierStyleCrossRef" href="#bib20">20</a> when analyzing newborns and cord blood&#44; it is possible that the subjects will develop the disease in the future&#59; and menopause itself produces regression of the disease in women who may be asymptomatic&#46;</p><p id="para200" class="elsevierStylePara elsevierViewall">Our control group was carefully selected among fertile and non-menopausal women who had undergone tubal ligation for family planning reasons and who had no sign of endometriosis in their clinical history&#46; Moreover&#44; the surgeon was able to observe while performing the ligation that there were no foci of endometriosis in these women&#46; This rigorous selection process of the control group may be responsible for the high level of significance of the results obtained&#46;</p><p id="para210" class="elsevierStylePara elsevierViewall">Clinically&#44; one of the primary concerns regarding endometriosis is its propensity to cause infertility&#46; It is currently estimated that 25&#37; to 50&#37; of women with endometriosis are infertile and that 25&#37; to 30&#37; of all infertile women have endometriotic lesions as the only identifiable cause of their infertility&#46;<a class="elsevierStyleCrossRefs" href="#bib1">1&#44;2</a> The association between endometriosis and infertility is <span class="elsevierStyleUnderline">well</span> established&#44; but the mechanisms responsible for these effects are unknown&#46; Several hypotheses have been proposed to explain how endometriosis causes infertility&#58; 1&#41; pelvic factors&#44; which include adhesions&#44; distort pelvic anatomy&#44;<a class="elsevierStyleCrossRef" href="#bib21">21</a> and alter peritoneal function&#59;<a class="elsevierStyleCrossRef" href="#bib22">22</a> 2&#41; ovarian factors that stem from endocrine and ovulatory disorders lead to oocyte and embryonic alteration&#59;<a class="elsevierStyleCrossRef" href="#bib23">23</a> and 3&#41; uterine factors cause impaired implantation&#46;<a class="elsevierStyleCrossRef" href="#bib24">24</a> Pisarska et al&#46;<a class="elsevierStyleCrossRef" href="#bib25">25</a> found an increase in the prevalence of PROGINS mutations among 26 women with the diagnosis of unexplained infertility compared to 28 control women &#40;42&#37; vs&#46; 14&#37;&#41;&#59; however&#44; in the current study&#44; the PROGINS polymorphism was not associated with infertility &#40;14&#46;0&#37; vs&#46; 11&#46;7&#37;&#41;&#46; Our results point to no association between idiopathic infertility and the PROGINS polymorphism&#59; however&#44; the power calculation of the sample was low&#44; suggesting that a larger sample is needed&#46;</p><p id="para220" class="elsevierStylePara elsevierViewall">It is important to keep in mind that the study was performed in a special group of patients who underwent surgery via video laparoscopy and&#44; after surgery&#44; were exposed for at least twelve months to the possibility of pregnancy&#44; had no male factor involved in the causes of infertility and&#44; nevertheless&#44; did not achieve pregnancy&#46;</p></span><span id="cesec100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle160">CONCLUSION</span><p id="para230" class="elsevierStylePara elsevierViewall">In conclusion&#44; our data suggest that PROGINS is not related either to endometriosis-associated infertility or to idiopathic infertility in the population studied&#46; However&#44; further studies with much larger samples are needed to confirm the results for the idiopathic infertily group&#46;</p></span></span>"
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    "pdfFichero" => "main.pdf"
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    "fechaRecibido" => "2010-05-17"
    "fechaAceptado" => "2010-08-02"
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          "palabras" => array:5 [
            0 => "endometriosis"
            1 => "polymorphism"
            2 => "PROGINS"
            3 => "progesterone receptor gene"
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        "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">OBJECTIVE&#58;</span><p id="spara40" class="elsevierStyleSimplePara elsevierViewall">This study aimed to determine the frequency of the PROGINS polymorphism in women with endometriosis-associated infertility&#44; in infertile women without endometriosis and in controls&#46;</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">INTRODUCTION&#58;</span><p id="spara50" class="elsevierStyleSimplePara elsevierViewall">The human progesterone receptor gene has two isoforms that modulate the biological action of progesterone&#58; isoform A&#44; which is capable of inhibiting the activation of the estrogen receptors&#44; and isoform B&#44; which has the capacity to activate the estrogen receptors&#46; Several polymorphisms have been described for this gene&#44; among which one stands out&#58; a polymorphism named PROGINS&#44; which has been speculated to be related to the genesis of endometriosis by several studies with conflicting results&#46;</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">METHODS&#58;</span><p id="spara60" class="elsevierStyleSimplePara elsevierViewall">This was a prospective study that included 148 patients with endometriosis-associated infertility&#44; 50 idiopathic infertile patients and 179 fertile women as controls&#46; The PROGINS polymorphism was studied by PCR&#46;</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">RESULTS&#58;</span><p id="spara70" class="elsevierStyleSimplePara elsevierViewall">Genotypes P1P1&#44; P1P2 and P2P2 &#40;P2 representing the PROGINS polymorphism&#41; of the progesterone receptor gene presented frequencies of 93&#46;9&#37;&#44; 5&#46;4&#37; and 0&#46;7&#37;&#44; respectively&#44; in the women with endometriosis-associated infertility &#40;p &#61; 0&#46;2101&#44; OR &#61; 0&#46;51&#44; 95&#37; CI &#61; 0&#46;24-1&#46;09&#41;&#59; 94&#46;4&#37;&#44; 4&#46;2&#37; and 1&#46;4&#37;&#44; respectively&#44; in the patients with minimal&#47;mild endometriosis &#40;p &#61; 0&#46;2725&#44; OR &#61; 0&#46;53&#44; 95&#37; CI &#61; 0&#46;20-1&#46;43&#41;&#59; 93&#46;5&#37;&#44; 6&#46;5&#37; and 0&#37;&#44; respectively&#44; among the patients with moderate&#47;severe endometriosis &#40;p &#61; 0&#46;3679&#44; OR &#61; 0&#46;49&#44; 95&#37; CI &#61; 0&#46;18-1&#46;31&#41;&#59; 86&#46;0&#37;&#44; 14&#46;0&#37; and 0&#37;&#44; respectively&#44; in idiopathic infertile women &#40;p &#61; 0&#46;8146&#44; OR &#61; 1&#46;10&#44; 95&#37; CI &#61; 0&#46;46-2&#46;63&#41;&#59; and 88&#46;3&#37;&#44; 10&#46;6&#37; and 1&#46;1&#37;&#44; respectively&#44; in the control group&#46;</p></span> <span id="ceabs50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle50">CONCLUSION&#58;</span><p id="spara80" class="elsevierStyleSimplePara elsevierViewall">The data suggest that PROGINS is not related either to endometriosis-associated infertility or to idiopathic infertility in the population studied&#46;</p></span>"
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          "leyenda" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">OR &#61; odds ratio CI &#61; confidence interval</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="bottom" scope="col">Population studied&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
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                  \t\t\t\t  " align="center" valign="bottom" scope="col">n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="3" align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">PROGINS genotypes</th><th class="td" title="\n
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                  \t\t\t\t  " align="center" valign="bottom" scope="col">p values&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="2" align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">Alleles</th><th class="td" title="\n
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                  \t\t\t\t  " align="center" valign="bottom" scope="col">p values&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="bottom" scope="col">OR &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">P1P1 &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">P1P2 &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">P2P2 &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">P1 &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">P2 &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Endometriosis-associated infertility patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">148&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">139 &#40;93&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">8 &#40;5&#46;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1 &#40;0&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;2101&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">286 &#40;96&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">10 &#40;3&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;1117&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;51 &#40;0&#46;24-1&#46;09&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Minimal&#47;mild endometriosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">67 &#40;94&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">3 &#40;4&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1 &#40;1&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;2725&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">137 &#40;96&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">5 &#40;3&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;2899&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;53 &#40;0&#46;20-1&#46;43&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Moderate&#47;severe endometriosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">72 &#40;93&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">5 &#40;6&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0 &#40;0&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;3679&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">149 &#40;96&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">5 &#40;3&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;2161&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;49 &#40;0&#46;18-1&#46;31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Idiopathic infertile patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">43 &#40;86&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">7 &#40;14&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0 &#40;0&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;6126&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">93 &#40;93&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="top">7 &#40;7&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="top">1&#46;10 &#40;0&#46;46-2&#46;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleBold">Controls</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top"><span class="elsevierStyleBold">179</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="top"><span class="elsevierStyleBold">158 &#40;88&#46;3&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top"><span class="elsevierStyleBold">19 &#40;10&#46;6&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top"><span class="elsevierStyleBold">2 &#40;1&#46;1&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="top"><span class="elsevierStyleBold">335 &#40;93&#46;6&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top"><span class="elsevierStyleBold">23 &#40;6&#46;4&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Frequency of genotypes and alleles of the PROGINS progesterone receptor gene polymorphism in patients with endometriosis-associated infertility&#44; idiopathic infertile patients and in controls&#46;</p>"
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      1 => array:7 [
        "identificador" => "t2-cln_65p1073"
        "etiqueta" => "Table 2"
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        "tabla" => array:1 [
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
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                  \t\t\t\t  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Study&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">Population studied&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">Conclusion of the study&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="top">Weiser et al&#46;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="top">95 white women with endometriosis and 107 white women without endometriosis &#40;controls&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">PROGINS appears to be associated with endometriosis in white persons&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Lattuada et al&#46;<a class="elsevierStyleCrossRef" href="#bib9">9</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">131 Italian women affected by endometriosis and 127 Italian women without laparoscopic evidence of the disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">PROGINS polymorphism of the progesterone receptor may be associated with an increased risk of endometriosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">De Carvalho et al&#46;<a class="elsevierStyleCrossRef" href="#bib10">10</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">121 Women with surgically confirmed endometriosis and 281 controls with normal gynecological exams&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">PROGINS heterozygosis genotype frequencies were shown to be statistically higher in women with endometriosis than in controls&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Govidan et al&#46;<a class="elsevierStyleCrossRef" href="#bib11">11</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">100 Women with endometriosis&#44; 80 women with fibroids and 157 women with breast cancer along with 108 age-matched normal healthy women as controls&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">PROGINS can be considered to be a predisposing risk marker for breast cancer but not for endometriosis or uterine fibroids&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">van Kaam <span class="elsevierStyleItalic">et</span> al&#46;<a class="elsevierStyleCrossRef" href="#bib15">15</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">72 women with endometriosis&#44; 40 with adenomyosis in the uterine wall&#44; 102 gynecological patients without symptomatic endometriosis and 93 healthy females&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">The PROGINS polymorphism does not seem to modify the risk of deep-infiltrating endometriosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Present study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">148 women with endometriosis&#44; 50 idiopathic infertile women and 179 fertile women without a history of endometriosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">PROGINS is not related either to endometriosis-associated infertility or to idiopathic infertility in the population studied&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">PROGINS progesterone receptor gene polymorphisms in different studies&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "cebibsec10"
          "bibliografiaReferencia" => array:25 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endometriosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              LC Giudice \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              LC Kao \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(04)17403-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2004"
                        "volumen" => "364"
                        "paginaInicial" => "1789"
                        "paginaFinal" => "1799"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15541453"
                            "web" => "Medline"
                          ]
                        ]
                      ]
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                      "doi" => "10.1016/S0140-6736(04)17403-5"
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                        "link" => "10&#46;1016&#47;S0140-6736&#40;04&#41;17403-5"
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              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The epidemiology of endometriosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              SA Missmer \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              DW Cramer \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/s0889-8545(02)00050-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Obstet Gynecol Clin North Am"
                        "fecha" => "2003"
                        "volumen" => "30"
                        "paginaInicial" => "1"
                        "paginaFinal" => "19"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12699255"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/s0889-8545(02)00050-5"
                      "WWW" => array:1 [
                        "link" => "10&#46;1016&#47;S0889-8545&#40;02&#41;00050-5"
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                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "PTPN22 C1858T polymorphism in women with endometriosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              FM Gomes \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              B Bianco \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              JS Teles \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              DM Christofolini \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              AM de Souza \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              AD Guedes \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0897.2009.00797.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Reprod Immunol"
                        "fecha" => "2010"
                        "volumen" => "63"
                        "paginaInicial" => "227"
                        "paginaFinal" => "232"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20070289"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vascular endothelial growth factor gene &#43;405 C&#47;G polymorphism is associated with susceptibility to advanced stage endometriosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              SH Kim \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              YM Choi \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              SH Choung \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              JK Jun \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              JG Kim \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              SY Moon \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1093/humrep/dei146"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Reprod"
                        "fecha" => "2005"
                        "volumen" => "20"
                        "paginaInicial" => "2904"
                        "paginaFinal" => "2908"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15979997"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1093/humrep/dei146"
                      "WWW" => array:1 [
                        "link" => "10&#46;1093&#47;humrep&#47;dei146"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#43;1730 G&#47;A polymorphism of the estrogen receptor beta gene &#40;ERbeta&#41; may be an important genetic factor predisposing to endometriosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              B Bianco \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              DM Christofolini \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              FA Mafra \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              A Brandes \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              K Zulli \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              CP Barbosa \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.3109/00016340903297168"
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Obstet Gynecol Scand"
                        "fecha" => "2009"
                        "volumen" => "88"
                        "paginaInicial" => "1397"
                        "paginaFinal" => "1401"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19878085"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.3109/00016340903297168"
                      "WWW" => array:1 [
                        "link" => "10&#46;3109&#47;00016340903297168"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Does gestrinone antagonize the effects of estrogen on endometrial implants upon the peritoneum of rats&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              VL Lobo \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              JM Soares Jr \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              M de Jesus Sim&#245;es \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              S Sim&#245;es Rdos \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              GR de Lima \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              EC Baracat \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1590/s1807-59322008000400019"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clinics"
                        "fecha" => "2008"
                        "volumen" => "63"
                        "paginaInicial" => "525"
                        "paginaFinal" => "530"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18719766"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1590/s1807-59322008000400019"
                      "WWW" => array:1 [
                        "link" => "10&#46;1590&#47;S1807-59322008000400019"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human progesterone receptor gene polymorphism PROGINS and risk for breast cancer in Austrian women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              G Fabjani \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              D Tong \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              K Czerwenka \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              E Schuster \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              P Speiser \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              S Leodolter \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Breast Cancer Res Treat"
                        "fecha" => "2002"
                        "volumen" => "72"
                        "paginaInicial" => "131"
                        "paginaFinal" => "137"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "10&#46;1023&#47;A&#58;1014813931765"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "PROGINS Alu insertion and human genomic diversity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              CJ Donaldson \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              JP Crapanzano \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              JC Watson \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              EA Levine \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              MA Batzer \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0027-5107(02)00015-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mutat Res"
                        "fecha" => "2002"
                        "volumen" => "501"
                        "paginaInicial" => "137"
                        "paginaFinal" => "141"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11934445"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "PROGINS receptor gene polymorphism is associated with endometriosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              F Wieser \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              C Schneeberger \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              D Tong \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              C Tempfer \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              JC Huber \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              R Wenzl \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/s0015-0282(01)02984-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Fertil Steril"
                        "fecha" => "2002"
                        "volumen" => "77"
                        "paginaInicial" => "309"
                        "paginaFinal" => "312"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11821088"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/s0015-0282(01)02984-3"
                      "WWW" => array:1 [
                        "link" => "10&#46;1016&#47;S0015-0282&#40;01&#41;02984-3"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetics of endometriosis&#58; a role for the progesterone receptor gene polymorphism PROGINS&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              D Lattuada \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              E Somigliana \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              P Vigano \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              M Candiani \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              G Pardi \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              AM Di Blasio \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Endocrinol"
                        "fecha" => "2004"
                        "volumen" => "61"
                        "paginaInicial" => "190"
                        "paginaFinal" => "194"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "10&#46;1111&#47;j&#46;1365-2265&#46;2004&#46;02076&#46;x"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic polymorphisms of cytochrome P450cl7alpha &#40;CYP17&#41; and progesterone receptor genes &#40;PROGINS&#41; in the assessment of endometriosis risk"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              CV De Carvalho \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              NC Nogueira-De-Souza \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              AM Costa \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              EC Baracat \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              MJ Gir&#227;o \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              P D&#39;Amora \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1080/09513590601024707"
                      "Revista" => array:7 [
                        "tituloSerie" => "Gynecol Endocrinol"
                        "fecha" => "2007"
                        "volumen" => "23"
                        "paginaInicial" => "29"
                        "paginaFinal" => "33"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17484509"
                            "web" => "Medline"
                          ]
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                        "itemHostRev" => array:3 [
                          "pii" => "S0140673600025277"
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                          "issn" => "01406736"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of progesterone receptor gene polymorphism &#40;PROGINS&#41; with endometriosis&#44; uterine fibroids and breast cancer"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              S Govindan \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              SN Ahmad \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              B Vedicherla \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              V Kodati \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              P Jahan \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              KP Rao \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cancer Biomark"
                        "fecha" => "2007"
                        "volumen" => "3"
                        "paginaInicial" => "73"
                        "paginaFinal" => "78"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "Revised American Society for Reproductive Medicine classification of endometriosis&#58; 1996"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0015-0282(97)81391-x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Fertil Steril"
                        "fecha" => "1997"
                        "volumen" => "67"
                        "paginaInicial" => "817"
                        "paginaFinal" => "821"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9130884"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A genetic mutation in progesterone receptor &#40;PROGINS&#41; leads to an increased risk of non-familial breast and ovarian cancer causing inadequate control of estrogen receptor driven proliferation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              DG Kieback \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              XW Tong \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              NL Weigel \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              IU Agoulnik \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Soc Gynecol Invest"
                        "fecha" => "1998"
                        "volumen" => "5"
                        "numero" => "1 Suppl 1"
                        "paginaInicial" => "40A"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "10&#46;1016&#47;S1071-5576&#40;97&#41;86082-0"
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                    ]
                  ]
                ]
              ]
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            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disrupted cell cycle control in cultured endometrial cells from patients with endometriosis harboring the progesterone receptor polymorphism PROGINS"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              P D&#39;Amora \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              TT Maciel \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              R Tambellini \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              MA Mori \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              JB Pesquero \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              H Sato \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2353/ajpath.2009.080966"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Pathol"
                        "fecha" => "2009"
                        "volumen" => "175"
                        "paginaInicial" => "215"
                        "paginaFinal" => "224"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19497994"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Progesterone receptor polymorphism &#43;331G&#47;A is associated with a decreased risk of deep infiltrating endometriosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              KJ van Kaam \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              A Romano \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              JP Schouten \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              GA Dunselman \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              PG Groothuis \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1093/humrep/del325"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Reprod"
                        "fecha" => "2007"
                        "volumen" => "22"
                        "paginaInicial" => "129"
                        "paginaFinal" => "135"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16920727"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1093/humrep/del325"
                      "WWW" => array:1 [
                        "link" => "10&#46;1093&#47;humrep&#47;del325"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association between PTPN22 and endometriosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              M Ammendola \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              N Bottini \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              A Pietropolli \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              P Saccucci \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              F Gloria-Bottini \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.fertnstert.2007.04.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "Fertil Steril"
                        "fecha" => "2008"
                        "volumen" => "89"
                        "paginaInicial" => "993"
                        "paginaFinal" => "994"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17624340"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.fertnstert.2007.04.008"
                      "WWW" => array:1 [
                        "link" => "10&#46;1016&#47;j&#46;fertnstert&#46;2007&#46;04&#46;008"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of p53 codon 72 polymorphism with endometriosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              M Ammendola \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              F Gloria-Bottini \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              F Sesti \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              E Piccione \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              E Bottini \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.fertnstert.2007.06.051"
                      "Revista" => array:6 [
                        "tituloSerie" => "Fertil Steril"
                        "fecha" => "2008"
                        "volumen" => "90"
                        "paginaInicial" => "406"
                        "paginaFinal" => "408"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17931634"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.fertnstert.2007.06.051"
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                        "link" => "10&#46;1016&#47;j&#46;fertnstert&#46;2007&#46;06&#46;051"
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                    ]
                  ]
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              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Polymorphisms in the estrogen receptor beta gene but not estrogen receptor alpha gene affect the risk of developing endometriosis in a Japanese population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              Z Wang \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              S Yoshida \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              K Negoro \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              S Kennedy \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              D Barlow \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              T Maruo \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Fertil Steril"
                        "fecha" => "2004"
                        "volumen" => "81"
                        "paginaInicial" => "1650"
                        "paginaFinal" => "1656"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "10&#46;1016&#47;j&#46;fertnstert&#46;2004&#46;02&#46;094"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "OC-125 immunostaining in endometriotic lesion samples"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              CP Barbosa \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              AM de Souza \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              B Bianco \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              DM Christofolini \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              FA Mafra \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              GR de Lima \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Arch Gynecol Obstet"
                        "fecha" => "2009 Apr 12"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Etiology of infertility in monkeys with endometriosis&#58; luteinized unruptured follicles&#44; luteal phase defects&#44; pelvic adhesions&#44; and spontaneous abortions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              RS Schenken \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              RH Asch \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              RF Williams \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              GD Hodgen \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0015-0282(16)47552-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Fertil Steril"
                        "fecha" => "1984"
                        "volumen" => "41"
                        "paginaInicial" => "122"
                        "paginaFinal" => "130"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6420199"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Peritoneal environment&#44; cytokines and angiogenesis in the physiopathology of endometriosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              R Gazvani \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              A Templeton \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1530/rep.0.1230217"
                      "Revista" => array:6 [
                        "tituloSerie" => "Reproduction"
                        "fecha" => "2002"
                        "volumen" => "123"
                        "paginaInicial" => "217"
                        "paginaFinal" => "226"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11866688"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1530/rep.0.1230217"
                      "WWW" => array:1 [
                        "link" => "10&#46;1530&#47;rep&#46;0&#46;1230217"
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                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exploring the mechanism&#40;s&#41; of endometriosis-related infertility&#58; an analysis of embryo development and implantation in assisted reproduction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              A Pellicer \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              N Oliveira \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              A Ruiz \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              J Remoh&#237; \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              C Sim&#243;n \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Reprod"
                        "fecha" => "1995"
                        "volumen" => "10"
                        "numero" => "Suppl 2"
                        "paginaInicial" => "91"
                        "paginaFinal" => "97"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              LC Kao \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              A Germeyer \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              S Tulac \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              S Lobo \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              JP Yang \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              RN Taylor \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1210/en.2003-0043"
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocrinology"
                        "fecha" => "2003"
                        "volumen" => "144"
                        "paginaInicial" => "2870"
                        "paginaFinal" => "2881"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12810542"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1210/en.2003-0043"
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                        "link" => "10&#46;1210&#47;en&#46;2003-0043"
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                ]
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            ]
            24 => array:3 [
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A mutated progesterone receptor allele is more prevalent in unexplained infertility"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              MD Pisarska \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              SA Carson \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              PR Casson \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              X Tong \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              JE Buster \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              DG Keiback \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/s0015-0282(03)00755-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Fertil Steril"
                        "fecha" => "2003"
                        "volumen" => "80"
                        "paginaInicial" => "651"
                        "paginaFinal" => "653"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12969718"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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        "texto" => "<p id="para240" class="elsevierStylePara elsevierViewall">The authors wish to thank Dr&#46; Karina Zulli for her help in selecting the patients with endometriosis and the control group and NEPAS &#40;Study&#44; Research and Health Assistance Nucleus of the ABC Faculty of Medicine&#41; for granting Fernanda Abani Mafra a Scientific Initiation scholarship&#46;</p>"
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Article information

ISSN: 18075932
Original language: English

DOI:10.1590/S1807-59322010001100002

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2024 March	54	12	66
2024 February	65	10	75
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2023 December	27	24	51
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2023 October	25	20	45
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2023 July	11	13	24
2023 June	20	13	33
2023 May	35	0	35
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