Cardiovascular pre-anesthesia evaluation in oncological surgery

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"figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 938 "Ancho" => 1318 "Tamanyo" => 100620 ] ] "descripcion" => array:1 [ "en" => "Search of information flowchart." ] ] ] "textoCompleto" => "IntroductionCancer per se is a pro-thrombotic condition, but it was only until 1865 that Armand Trousseau associated thrombosis and cancer for the first time. The risk of cancer-related thrombosis seems to be higher in patients with metastatic disease and in those with risk factors.EpidemiologyCancer represents a group of pathologies with huge social, economic, and emotional impact. It has been estimated that there are over 11 million new cancer cases every year, of which around 80% present in developing countries. In Colombia cancer is a growing public health challenge, with an incidence of around 70,887 new cases per year, according to the estimates from 2000 to 2006 (32,316 cases in males and 38,571 cases in females). In men, the main cancer sites were in order of importance: prostate, stomach, lung, rectum and non-Hodgkin lymphomas. In women, the most common sites were: breast, cervix, thyroid, stomach, colon, rectum and anus.<a class="elsevierStyleCrossRef" href="#bib0275">1</a>DefinitionPre-anesthesia evaluation as part of the anesthetic procedure is defined as the process of clinical evaluation that precedes surgery and the administration of anesthesia. Such evaluation comprises the information collected from multiple sources, including the patient's medical record, the interview, the physical examination, lab tests, and inter-consultation with other specialities.<a class="elsevierStyleCrossRefs" href="#bib0280">2,3</a>The main goal of pre-anesthesia evaluation is to assess any potential cardiovascular risks that may arise in the course of surgery, collecting all the information required on the extension and stability cardiovascular disease, if any, or any cardiovascular risk factors, understanding the scope of the procedure in order to adopt strategies that help to mitigate risks, as well as any short and long term adverse outcomes.<a class="elsevierStyleCrossRefs" href="#bib0290">4–7</a>The specific characteristics of the disease, the social conditions, and even the healthcare coverage have generated a new challenge for the cardiovascular management of cancer patients. The higher survival rates and access to healthcare are additional considerations in the management of patients. Aging and age-related physiological and pathological changes have led to new approaches to the cardiovascular management strategy in the elderly population, with emphasis on age as an independent risk factor for perioperative morbidity and mortality.<a class="elsevierStyleCrossRefs" href="#bib0310">8–11</a>In accordance with The National Confidential Enquiry Into Patient, Outcome and Death (NCPOD), most surgeries in cancer patients are a high priority and hence should not be delayed<a class="elsevierStyleCrossRef" href="#bib0330">12</a>; however, notwithstanding the availability of pre-anesthesia evaluation guidelines, these procedures are often delayed due to inadequate approaches or unnecessary pre-surgical testing.The cancer patient is a challenge for the anesthesiologist due to all the factors involved, such as the exposure to chemotherapeutic agents or radiation therapy and the consequences thereof. Cardiotoxicity is one of the most relevant complications of cancer chemotherapy that affects patients and increases with age; cardiotoxicity may show gender differences. The oncological approach and the management of cancer patients should be a joint effort between clinical oncology and cardiology. Very often the cardiovascular risk is underestimated in cancer patients and these patients will usually undergo cancer surgery and then cardiovascular surgery.<a class="elsevierStyleCrossRefs" href="#bib0335">13–16</a>This paper was intended to review the literature and consider new approaches to pre-anesthesia cardiovascular evaluation of cancer patients, in order to reassess the current approaches used at referral centers.MethodologyA literature review was completed searching English and Spanish articles published since 1995, using the following keywords neoplasm, cancer centers, medical oncology, anesthesia, anesthesia recovery period, cardiovascular diseases with combinations including AND, OR, ADJ, NOT or NAND, XOR. The major databases accessed were: PubMed, OVID, MedLine, The Cochrane Library, Embase, Lilacs. Articles were selected on the basis of the title, the abstract, date of publication, language and the relationship to the subject being reviewed. (The selection process is illustrated in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>.)<elsevierMultimedia ident="fig0005"></elsevierMultimedia>Cardiovascular risk factors and cardiotoxicity of cancer patientsCardiovascular complications are becoming more evident as survival increases after the diagnosis and as a result of combined chemotherapy approaches. It is important to emphasize that the selection of the chemotherapeutic agent and the survival prognosis depend on a fine balance between cancer treatment and cardiovascular therapy; consequently, notwithstanding the fact that cardiac monitoring is time-consuming and expensive, it is nonetheless highly recommended.Physiological aging is an independent risk factor for perioperative morbidity and mortality, due to changes such as stiffness of the connective tissue that reduces the compliance of the veins, the arteries and the myocardial tissue, and leads to systolic hypertension, increased afterload and myocardial hypertrophy. Moreover, a decreased beta-receptor response reduces the heart rate and the contractile response to hypotension, to exertion and the exogenous administration of catecholamine. Not to mention the cell loss at the sinoatrial node and subsequent heart rate disorders. The ischemic pre-conditioning effect that protects against secondary infarction in extended – though not indefinite – ischemia, seems to be absent in elderly patients and makes them more vulnerable to ischemic heart attacks.<a class="elsevierStyleCrossRefs" href="#bib0310">8–10</a>In the long term, cancer survivors have a high incidence of hypertension, dyslipidemia, acute coronary syndromes and acute CVAs, in addition to the risk of chemotherapy exposure that is reported to be similar to smoking. On top of the subsequent and concurrent exposure to a number of cardiovascular noxae, the patient experiences lifestyle changes. Usually, upon learning about his/her diagnosis, the patient quits exercising, tends to gain weight and to become depressed. Depression is acknowledged as a new risk factor for coronary disease.Pre-existing cardiovascular risk factors are strong predictors for later chemotherapy-mediated cardiotoxicity.Thyroxin kinase inhibitors have been associated with hypertension and cardiotoxicity, while the anti-vascular endothelial growth factor bevacizumab has been associated with pulmonary embolism, pulmonary bleeding, pulmonary edema and GI tract bleeding. Other symptoms like hypotension or hypertension, arrhythmias, cardiac failure, left ventricular dysfunction are seen in patients treated with monoclonal antibodies, interleukins and alpha-interferon.Other agents that seem to have an effect on the vascular system are the selective estrogen receptors modulators like tamoxifen that induces changes in the high and low-density lipoproteins.<a class="elsevierStyleCrossRefs" href="#bib0335">13–16</a>Some drugs such as anthracycline medications may lead to congestive heart failure and left ventricular dysfunction and is more frequently observed in women with heart disease. Other antimetabolite agents such as capecitabine or citarabine may cause ischemia, pericarditis, heart failure, and cardiogenic shock.<a class="elsevierStyleCrossRefs" href="#bib0555">19–21</a>Cardiotoxicity from fluoropiridines such as 5-fluorouracil is expressed as myocardial ischemia that is evidenced in the electrocardiographic tracing. Antimicrotubular molecules such as paclitaxel or the vinca alkaloids are involved in sinus bradycardia, AV block, ventricular tachycardia, hypotension, heart failure and ischemia.<a class="elsevierStyleCrossRefs" href="#bib0570">22–25</a>Sub-endocardial fibrosis secondary to carcinoid heart or tumor infiltration that typically causes thickening of the tricuspid and pulmonary valves is found in up to 60% of the patients with carcinoid heart. Although valve regurgitation is the usual outcome, stenosis may also occur. Valve disease on its own, associated with endocardial fibrosis, finally results in right ventricular failure and death. Extension of the disease is less common to the left side of the heart, though the echocardiographic detection of a drop in the left ventricular ejection fraction is suggestive of endocardic fibrosis extending into the left heart.<a class="elsevierStyleCrossRefs" href="#bib0545">17,18</a>Radiation therapy to the mediastinum has been associated with myocardial fibrosis, left heart valve disease, and endothelial cell damage.<a class="elsevierStyleCrossRefs" href="#bib0400">26,27</a>Preoperative evaluationMorbidity during the perioperative period is directly related to underlying surgical pathology, the patient's comorbidities, the extent of surgery, and the age-related physiological reserve, as established under the American Heart Association (AHA) or the European Guidelines.Cardiac death and non-fatal MI are associated with major surgeries such as surgery over the aorta, major vascular surgery, and peripheral vascular surgery with a mortality that exceeds 5%. Intermediate risk surgeries exhibit mortality rates ranging from 1% to 5%. These include intraperitoneal and intrathoracic surgery, carotid endarterectomy, head and neck surgery, orthopedic surgery and prostate surgery. Finally, the low risk surgeries with a risk of death below 1% include endoscopic procedures, cataract surgery, breast surgery, superficial and outpatient procedures.The functional status is another item in the pre-anesthesia cardiovascular evaluation. It is easily measured through the performance of everyday activities in metabolic equivalents that are extrapolated according to the physical activity that the patient is able to perform, based on pre-established targets under the American and European Guidelines.<a class="elsevierStyleCrossRefs" href="#bib0295">5,6</a>A number of mortality predictors have been developed throughout the years for the coronary patient undergoing non-coronary surgery that are constantly used for pre-anesthesia evaluations such as the Goldman index, the revised Lee cardiac index, Detsky score or modified Goldman, and the Boersma, among others. These indexes summarize the patient's comorbidities and the level of compensation, age as an independent risk factor and the functional class.<a class="elsevierStyleCrossRefs" href="#bib0410">28–30</a>Despite the identification of risk factors in the cancer patient, including any pre-existing risk factors before the onset of cancer – i.e., hypertension, dislipidemia, diabetes, etc. – and those derived from cancer as a systemic disease and from cancer treatment, there are few convincing data to predict which patients will develop chemotherapy-related cardiotoxicity. Systolic dysfunction seems to be the most common manifestation, though diastolic dysfunction may also be found. Once the dysfunction occurs, its progression is almost unavoidable and mortality is high. So a lot of emphasis is placed on early detection of systolic dysfunction in patients undergoing chemotherapy.Cancer treatment causes endothelial dysfunction and thus accelerates the atherosclerotic process, leading to an increased risk of developing cardiovascular events later in life. Early identification of cancer patients at high risk of developing cardiovascular events continues to be the key strategy to reduce morbidity and mortality; however, there are no recommendations at present in that regard.Ejection fraction is one of the most important predictors in the prognosis of patients undergoing chemotherapy and radiotherapy at high risk of developing cardiotoxicity. However, the ejection fraction is a low sensitivity tool during the early stages of cardiotoxicity; moreover, a normal left ventricular ejection fraction does not rule out the potential for later decline. Magnetic resonance is the gold standard for evaluating cardiac volume, cardiac mass, and systolic and diastolic function; however, the cost or MRI is high and its availability is limited. Troponins have been used as biomarkers for acute cardiotoxicity, in combination with natriuretic peptides, but there is no evidence as to the role they play, except when the heart damage is already established. Troponins are highly sensitive to identify minor necrosis. In every clinical context, troponins do not only allow for the identification of myocardial damage, but they are also used as a tool to stratify cardiac risk. In fact, high sensitivity troponins may be particularly useful in cardiotoxicity from chemotherapeutic agents, but further studies are needed to determine their accuracy. In terms of endothelial damage, endothelial damage markers such as endogenous nitric oxide inhibitors and symmetric/asymmetric dimethyl arginines have been measured and identified after several years.Other measurements such as the thickening of the intima of the carotid have also been used as markers of endothelial damage. Early detection of decreased left ventricle contractility using dobutamine stress echocardiography is another option for the early detection of a decline in ejection fraction following high doses of chemotherapy, even at early stages before being identified with conventional echocardiography l.<a class="elsevierStyleCrossRefs" href="#bib0425">31–38</a>ConclusionThese patients represent a new challenge for referral cancer centers and for the multidisciplinary teams managing these patients. Anesthesiologists have to deal with a top priority surgery, in patients with multiple cardiovascular risk factors since a large percentage of these patients are 65 or older. The risk of the procedure alone is at a 5% level (intermediate risk) in terms of perioperative morbidity and mortality, in addition to the exposure to chemotherapeutic cardiotoxic agents or radiation therapy in a large proportion of these patients.To what extent shall we stratify these patients in terms of their cardiovascular risk?It is clear that cancer behaves as a systemic disease that affects all kinds of people and requires a multidisciplinary approach. It is highly recommended that cancer centers become aware of the need to involve the cardiologist during the treatment of cancer and integrate cardio-oncology teams to manage and monitor these patients.The pre-anesthesia evaluation should consider cardiovascular evaluation a priority. Extrapolating the guidelines for coronary patients to non-cardiac surgery is difficult because of the nature of the disease, the cytoreduction process involved and the rate at which the disease stage may progress. Naturally, every coronary risk factor should be controlled, but to what extent should a patient undergo cancer surgery when uncontrolled risk factors for coronary disease are present?Past studies have shown that prophylactic myocardial revascularization does not improve survival and is only an option for patients with unstable coronary syndromes and advanced coronary disease that do benefit from the procedure.<a class="elsevierStyleCrossRefs" href="#bib0465">39–45</a>Surgical procedures such as Sugar Baker's, inter alia, with the multiple physiological variables that have to be controlled, entail more than an intermediate risk and may even be considered major surgeries with adverse cardiac outcomes that deserve complementary studies and specific stratification to rule out coronary disease.<a class="elsevierStyleCrossRefs" href="#bib0500">46–54</a>Cardiovascular risk factors should be closely controlled, particularly in patients that will later be transferred to the ICU. We should then include exposure to chemotherapy or radiation therapy in the list of risk factors for this population, together with strategies for prevention, detection, and treatment for cardiotoxicity resulting from both chemo and radiation therapy. Consequently, patients with predictors of intermediate risk that have been exposed to cycles of mediastinal chemotherapy or radiotherapy and will undergo intermediate risk cancer surgery should at least present with a left ventricle ejection fraction evaluation combined with biomarkers. Is it necessary to evaluate the myocardial reserve in these patients?There are still several unanswered questions about the perioperative cardiovascular evaluation of the patient undergoing cancer surgery. Though the answers may seem obvious, this is not usually the case in everyday practice. Further studies are needed to be able to address these concerns and provide strong guidance for the pre-anesthesia evaluation and perioperative cardiovascular care of the surgical cancer patient.FundingThe authors did not receive sponsorship to undertake this article.Conflicts of interestThe authors have no conflicts of interest to declare." 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Pre-anesthesia evaluation as part of the anesthetic activity is defined as the process of clinical evaluation before surgery and the administration of anesthesia per se. This review is intended to reassess the current approach to cardiovascular pre-anesthesia evaluation in cancer patients at referral centers. The search strategy used the major databases in the scientific literature, based on the keywords identified. The conclusion is that cardiovascular risk factors must be closely controlled and hence the approach to the management of the cancer patient should be in cooperation with clinical oncology and cardiology. The evaluation should include the ejection fraction as one of the most relevant predictors of the patient's prognosis." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "El paciente con cáncer representa un desafío para el anestesiólogo debido a los factores de riesgo cardiovascular incrementados por su condición y a una mayor toxicidad por la quimioterapia que recibe. La evaluación preanestésica como parte del acto anestésico se define como el proceso de valoración clínica que precede al acto quirúrgico en el que se suministra anestesia. El objetivo de la presente revisión es replantear la manera como actualmente se está enfocando la evaluación pre-anestésica cardiovascular en los pacientes oncológicos en centros de referencia. La estrategia de búsqueda se realizó en las principales bases de datos con la búsqueda de literatura científica de acuerdo a palabras clave definidas. Como recomendaciones se concluye que los factores de riesgo cardiovascular se deben controlar en lo posible y por esto el enfoque y manejo oncológico del paciente debería hacerse en conjunto con las especialidades de oncología clínica y cardiología. Se debería incluir la fracción de eyección en esta valoración como uno de los predictores más importantes para el pronóstico de los pacientes." ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Gómez-Henao PA, Dueñas JAC. Evaluación preanestésica cardiovascular en cirugía oncológica. Rev Colomb Anestesiol. 2016;44:17–22." ] ] "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "fuente" => "Source: Authors." "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 938 "Ancho" => 1318 "Tamanyo" => 100620 ] ] "descripcion" => array:1 [ "en" => "Search of information flowchart." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:54 [ 0 => array:3 [ "identificador" => "bib0275" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Ministerio de Salud y Protección Social, Instituto Nacional de Cancerología, Plan decenal para el control del cáncer en Colombia 2012–2021." ] ] ] 1 => array:3 [ "identificador" => "bib0280" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Practice advisory for preanesthesia evaluation. An update report for the American Society of Anesthesiologists: Task force on preanesthesia evaluation" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "Committee on Standards and Practice Parameters" "etal" => true "autores" => array:6 [ 0 => "Committee on Standards and Practice Parameters" 1 => "J.L. Apfelbaum" 2 => "R.T. Connis" 3 => "D.G. Nickinovich" 4 => "American Society of Anesthesiologists Task Force on Preanesthesia Evaluation" 5 => "L.R. Pasternak" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/ALN.0b013e31823c1067" "Revista" => array:6 [ "tituloSerie" => "Anesthesiology" "fecha" => "2012" "volumen" => "116" "paginaInicial" => "522" "paginaFinal" => "538" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22273990" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0285" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Preoperative medical consultations: impact of perioperative management and surgical outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.I. Katz" 1 => "L. Cimino" 2 => "S.A. Vitkun" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/BF03016556" "Revista" => array:6 [ "tituloSerie" => "Can J Anaesth" "fecha" => "2005" "volumen" => "52" "paginaInicial" => "697" "paginaFinal" => "702" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16103381" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0290" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A survey on the intended purposes and perceived utility of preoperative cardiology consultations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R.I. Katz" 1 => "J.M. Barnhart" 2 => "G. Ho" 3 => "D. Hersch" 4 => "S.S. Dayan" 5 => "L. Keehn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anesth Analg" "fecha" => "1998" "volumen" => "87" "paginaInicial" => "830" "paginaFinal" => "836" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9768778" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0295" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "2009 ACCF/AHA focused update on periopertaive beta blocked incorporated into the ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery preoperative cardiovascular assessment in non-cardiac surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L.A. Fleisher" 1 => "J.A. Beckman" 2 => "K.A. Brown" 3 => "H. Calkins" 4 => "E.L. Chaikof" 5 => "K.E. Fleischmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2009.07.010" "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2009" "volumen" => "54" "paginaInicial" => "e13" "paginaFinal" => "e118" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19926002" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0300" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiovascular aging and anesthetic implications" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.A. Rooke" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cardiothorac Vasc Anesth" "fecha" => "2003" "volumen" => "17" "paginaInicial" => "512" "paginaFinal" => "523" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12968244" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0305" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Preoperative evaluation of patients with, or at risk of, coronary artery disease undergoing non-cardiac surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.G. Chassot" 1 => "A. Delabays" 2 => "D.R. Spahn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Anaesth" "fecha" => "2002" "volumen" => "89" "paginaInicial" => "747" "paginaFinal" => "759" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12393774" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0310" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diastolic dysfunction in the older heart" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L. Groban" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cardiothorac Vasc Anesth" "fecha" => "2005" "volumen" => "19" "paginaInicial" => "228" "paginaFinal" => "236" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15868536" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0315" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spectrum of heart failure in older patients: results from the National Heart Failure Project" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E.P. Havranek" 1 => "F.A. Masoudi" 2 => "K.A. Westfall" 3 => "P. Wolfe" 4 => "D.L. Ordin" 5 => "H.M. Krumholz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am Heart J" "fecha" => "2002" "volumen" => "143" "paginaInicial" => "412" "paginaFinal" => "417" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11868045" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0320" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relative importance of preoperative health status versus intraoperative factors predicting postoperative adverse outcomes in geriatric surgical patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.M. Leug" 1 => "S. Dzankic" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Geriatr Soc" "fecha" => "2001" "volumen" => "49" "paginaInicial" => "1080" "paginaFinal" => "1085" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11555070" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0590" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Knowing the risk: a review of the perioperative care of surgical patients A report by the National confidential Enquiry into Patient Outcome and Death" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.P. Findlay" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:1 [ "fecha" => "2011" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0330" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Albini" 1 => "G. Pennesi" 2 => "F. Donatelli" 3 => "R. Cammarota" 4 => "S. De Flora" 5 => "D.M. Noonan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/jnci/djp440" "Revista" => array:6 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "2010" "volumen" => "102" "paginaInicial" => "14" "paginaFinal" => "25" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20007921" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0335" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.T. Yeh" 1 => "A.T. Tong" 2 => "D.J. Lenihan" 3 => "S.W. Yusuf" 4 => "J. Swafford" 5 => "C. Champion" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.CIR.0000133187.74800.B9" "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2004" "volumen" => "109" "paginaInicial" => "3122" "paginaFinal" => "3131" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15226229" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0340" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "V.B. Pai" 1 => "M.C. Nahata" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Drug Saf" "fecha" => "2000" "volumen" => "22" "paginaInicial" => "263" "paginaFinal" => "302" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10789823" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0345" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chemotherapy and cardiotoxicity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. Broder" 1 => "R. Gottlieb" 2 => "N. Lepor" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Cardiovasc Med" "fecha" => "2008" "volumen" => "9" "paginaInicial" => "75" "paginaFinal" => "83" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18660728" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0350" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinoid tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Kulke" 1 => "R. Mayer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199903183401107" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1999" "volumen" => "340" "paginaInicial" => "858" "paginaFinal" => "868" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10080850" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0545" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiovascular manifestation of endocryne dysfunction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.J. Deegan" 1 => "W.R. Furman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/j.jvca.2010.12.001" "Revista" => array:6 [ "tituloSerie" => "J Cardiothorac Vasc Anesth" "fecha" => "2011" "volumen" => "25" "paginaInicial" => "705" "paginaFinal" => "720" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21330154" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0550" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardioprotective interventions for cancer patients receiving anthracyclines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E.C. Van Dalen" 1 => "H.N. Caron" 2 => "H. Dickinson" 3 => "L.C. Kremer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Cochrane Database Syst Rev" "fecha" => "2005" "paginaInicial" => "CD003917" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0555" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Congestive heart failure and left ventricular dysfunction complicating doxorubicine therapy. Seven years experience using serial radionuclide angiocardiography" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R.G. Schwarts" 1 => "W.B. McKenzie" 2 => "J. Alexander" 3 => "P. Sager" 4 => "A. D'Souza" 5 => "A. Manatunga" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1987" "volumen" => "82" "paginaInicial" => "1109" "paginaFinal" => "1118" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3605130" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0560" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Simbre II IV, Adams MJ, Deshpande SS, Duffy SA, Miller TL, Lipshultz SE. Cardiomyopathy caused by antineoplastic therapies. Curr Treat Options Cardiovas Med. 2001;3:493–505." ] ] ] 20 => array:3 [ "identificador" => "bib0565" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prophylactic options in patients with 5-fluorouracil associated cardiotoxicity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Cianci" 1 => "M.F. Morelli" 2 => "K. Cannita" 3 => "R. Morese" 4 => "E. Ricevuto" 5 => "Z.C. Di Rocco" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.bjc.6600967" "Revista" => array:6 [ "tituloSerie" => "Br J Cancer" "fecha" => "2003" "volumen" => "88" "paginaInicial" => "1507" "paginaFinal" => "1509" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12771913" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0570" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiac dysfunction in the traztuzumab clinical trials experience" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Seidman" 1 => "C. Hudis" 2 => "M.K. Pierri" 3 => "S. Shak" 4 => "V. Paton" 5 => "M. Ashby" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.2002.20.5.1215" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2002" "volumen" => "20" "paginaInicial" => "1215" "paginaFinal" => "1221" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11870163" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0575" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hormonal therapy use for prostate cancer and mortality in men with coronary artery disease-induced congestive heart failure or myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Nanda" 1 => "M.H. Chen" 2 => "M.H. Braccioforte" 3 => "B.J. Moran" 4 => "A.V. D’Amico" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.2009.1137" "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "2009" "volumen" => "302" "paginaInicial" => "866" "paginaFinal" => "873" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19706860" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0580" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Statins and cancer: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Kuoppala" 1 => "A. Lamminpaa" 2 => "E. Pukkala" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ejca.2008.06.025" "Revista" => array:6 [ "tituloSerie" => "Eur J Cancer" "fecha" => "2008" "volumen" => "44" "paginaInicial" => "2122" "paginaFinal" => "2132" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18707867" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0585" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "American Society of Clinical Oncology Chemotherapy and Radiotherapy Expert Panel. 2002 update of recommendations for the use of chemotherapy and radiotherapy protectants: clinical practice guidelines of the American society of clinical oncology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L.M. Schucter" 1 => "M.L. Hensley" 2 => "N.J. Meropol" 3 => "E.P. Winwer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2002.04.178" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2002" "volumen" => "20" "paginaInicial" => "2895" "paginaFinal" => "2903" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12065567" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0400" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiac effects of radiation therapy and chemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.S. Rosenthal" 1 => "E. Braunwald" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Heart disease: a textbook of cardiovascular medicine" "paginaInicial" => "1746" "paginaFinal" => "1751" "serieFecha" => "2001" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0405" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Derivation and prospective validation of a simple index for prediction of cardiac risk of major no cardiac surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T.H. Lee" 1 => "E.R. Marcantonio" 2 => "C.M. Mangione" 3 => "E.J. Thomas" 4 => "C.A. Polanczyk" 5 => "E.F. Cook" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1999" "volumen" => "100" "paginaInicial" => "1043" "paginaFinal" => "1049" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10477528" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0410" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predicting cardiac complications in patients undergoing non-cardiac surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.S. Destky" 1 => "H.B. Abraham" 2 => "J.R. McLaughlin" 3 => "D.J. Drucker" 4 => "Z. Sasson" 5 => "N. Johnston" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Gen Intern Med" "fecha" => "1986" "volumen" => "1" "paginaInicial" => "211" "paginaFinal" => "219" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3772593" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0415" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The prognosis value of exercise capacity: a review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.K. Morris" 1 => "K. Ueshima" 2 => "T. Kawaguchi" 3 => "A. Hideg" 4 => "V.F. Froelicher" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am Heart J" "fecha" => "1991" "volumen" => "122" "paginaInicial" => "1423" "paginaFinal" => "1431" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1951007" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0420" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic value of troponin I in cardiac risk stratification of cancer patients undergoing high -dose chemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Cardinale" 1 => "M. Sandri" 2 => "A. Colombo" 3 => "M. Boeri" 4 => "G. Lamantia" 5 => "M. Civelli" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.CIR.0000130926.51766.CC" "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2004" "volumen" => "109" "paginaInicial" => "2749" "paginaFinal" => "2754" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15148277" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0425" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "N-terminal pro-B-type natriuretic peptide after high-dose chemotherapy: a marker predictive of cardiac dysfunction?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.T. Sandri" 1 => "M. Salvatici" 2 => "D. Cardinale" 3 => "L. Zorzino" 4 => "R. Passerini" 5 => "P. Lentati" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1373/clinchem.2005.050153" "Revista" => array:6 [ "tituloSerie" => "Clin Chem" "fecha" => "2005" "volumen" => "51" "paginaInicial" => "1405" "paginaFinal" => "1410" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15932966" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0430" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biochemical markers for prediction of chemotherapy-induced cardiotoxicity: systematic review of the literature and recommendations for use" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Dolci" 1 => "R. Dominici" 2 => "D. Cardinale" 3 => "M.T. Sandri" 4 => "M. Panteghini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1309/AJCPB66LRIIVMQDR" "Revista" => array:6 [ "tituloSerie" => "Am J Clin Pathol" "fecha" => "2008" "volumen" => "130" "paginaInicial" => "688" "paginaFinal" => "695" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18854260" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0435" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biomarkers in heart failure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E. Braunwald" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMra0800239" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2008" "volumen" => "358" "paginaInicial" => "2148" "paginaFinal" => "2159" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18480207" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0440" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early reduction in left ventricular contractile reserve detected by dobutamina stress echo predicts high dose chemotherapy induced cardiac toxicity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Civelli" 1 => "D. Cardinale" 2 => "A. Martinoni" 3 => "G. Lamantia" 4 => "N. Colombo" 5 => "A. Colombo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijcard.2005.07.029" "Revista" => array:6 [ "tituloSerie" => "Int J Cardiol" "fecha" => "2006" "volumen" => "111" "paginaInicial" => "120" "paginaFinal" => "126" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16242796" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0445" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Strategies to prevent and treat cardiovascular risk in cancer patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Cardinale" 1 => "G. Bacchiani" 2 => "M. Beggiato" 3 => "A. Colombo" 4 => "C.M. Cipolla" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/j.seminoncol.2013.01.008" "Revista" => array:6 [ "tituloSerie" => "Semin Oncol" "fecha" => "2013" "volumen" => "40" "paginaInicial" => "186" "paginaFinal" => "198" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23540744" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0450" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiovascular disease in survivors of adolescent and young adult cancer: a Danish Cohort Study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "K. Rugbejerg" 1 => "L. Mellemkjaer" 2 => "D. Boice" 3 => "L. Kober" 4 => "M. Ewertz" 5 => "J.H. Olsen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/jnci/dju061" "Revista" => array:4 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "2014" "volumen" => "106" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24681604" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0455" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic value of routine cardiac magnetic resonance assessment of the left ventricular ejection fractioned myocardial damage: an international, multicenter study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Klem" 1 => "D.J. Shad" 2 => "R.D. White" 3 => "D.J. Pennell" 4 => "A.C. van Rossum" 5 => "M. Regenfus" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/CIRCIMAGING.111.964965" "Revista" => array:6 [ "tituloSerie" => "Circ Cardiovasc Imaging" "fecha" => "2011" "volumen" => "4" "paginaInicial" => "610" "paginaFinal" => "619" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21911738" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0460" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Coronary artery revascularization before elective mayor vascular surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Mcfalls" 1 => "H. Ward" 2 => "T. Moritz" 3 => "S. Goldman" 4 => "W.C. Krupski" 5 => "F. Littooy" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa041905" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2004" "volumen" => "351" "paginaInicial" => "2795" "paginaFinal" => "2804" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15625331" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0465" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Disparate opinions regarding indications for coronary artery revascularization prior to elective vascular surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Pierpont" 1 => "T. Moritz" 2 => "S. Goldman" 3 => "W.C. Krupski" 4 => "F. Littooy" 5 => "H.B. Ward" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjcard.2004.07.077" "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "2004" "volumen" => "94" "paginaInicial" => "1124" "paginaFinal" => "1128" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15518605" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0470" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Catastrophic outcomes of non-cardiac surgery soon after coronary stenting" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G.L. Kaluza" 1 => "J. Joseph" 2 => "J.R. Lee" 3 => "M.E. Raizner" 4 => "A.E. Raizner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2000" "volumen" => "35" "paginaInicial" => "1288" "paginaFinal" => "1294" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10758971" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0475" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fatal myocardial infarction after lung resection in a patient with prophylactic preoperative coronary stenting" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Marcucci" 1 => "P.G. Chassot" 2 => "J.P. Gardaz" 3 => "L. Magnusson" 4 => "H.B. Ris" 5 => "A. Delabays" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/bja/aeh110" "Revista" => array:6 [ "tituloSerie" => "Br J Anaesth" "fecha" => "2004" "volumen" => "92" "paginaInicial" => "743" "paginaFinal" => "747" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15003980" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0480" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Does preoperative coronary angioplasty improve perioperative cardiac outcome?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Godet" 1 => "B. Riou" 2 => "M. Bertrand" 3 => "M.H. Fléron" 4 => "J.P. Goarin" 5 => "G. Montalescot" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anesthesiology" "fecha" => "2005" "volumen" => "102" "paginaInicial" => "739" "paginaFinal" => "746" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15791102" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0485" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Coronary artery stenting and non-cardiac surgery- a prospective outcome study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.N. Vicenzi" 1 => "T. Meislitzer" 2 => "B. Heitzinger" 3 => "M. Halaj" 4 => "L.A. Fleisher" 5 => "H. Metzler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/bja/ael083" "Revista" => array:6 [ "tituloSerie" => "Br J Anaesth" "fecha" => "2006" "volumen" => "96" "paginaInicial" => "686" "paginaFinal" => "693" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16670113" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0490" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Late thrombosis in drug-eluting coronary stents after discontinuation of antiplatelet therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.P. McFadden" 1 => "E. Stabile" 2 => "E. Regar" 3 => "E. Cheneau" 4 => "A.T. Ong" 5 => "T. Kinnaird" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(04)17275-9" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2004" "volumen" => "364" "paginaInicial" => "1519" "paginaFinal" => "1521" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15500897" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0495" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Coronary revascularization writing group. ACCF/SCAI/STS/AATS/AHA/ASNC/HFSA/SCCT 2012 appropriate use criteria for coronary revascularization focused update: a report of the American College of Cardiology Foundation appropriate use criteria task force, Society for Cardiovascular Angiography and Interventions, Society of Thoracic Surgeons, American Association for Thoracic Surgery, American Heart Association, American Society of Nuclear Cardiology, and the Society of Cardiovascular Computed Tomography" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.R. Patel" 1 => "G.J. Dehmer" 2 => "J.W. Hirshfeld" 3 => "P.K. Smith" 4 => "J.A. Spertus" 5 => "F.A. Masoudi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jtcvs.2012.01.061" "Revista" => array:6 [ "tituloSerie" => "J Thorac Cardiovasc Surg" "fecha" => "2012" "volumen" => "143" "paginaInicial" => "780" "paginaFinal" => "803" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22424518" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0500" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prospective morbidity and mortality assessment of cytoreductive surgery plus perioperative intraperitoneal chemotherapy to treat peritoneal dissemination of appendiceal mucinous malignancy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.H. Sugarbaker" 1 => "R. Aldemar" 2 => "G. Edwards" 3 => "C.E. Marquardt" 4 => "V. Gushchin" 5 => "J. Esquivel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1245/ASO.2006.03.079" "Revista" => array:6 [ "tituloSerie" => "Ann Surg Oncol" "fecha" => "2006" "volumen" => "13" "paginaInicial" => "635" "paginaFinal" => "644" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16523363" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0505" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiovascular changes during continues hyperthermic peritoneal perfusion" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "N. Shime" 1 => "M. Lee" 2 => "T. Hatanaka" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anesth Analg" "fecha" => "1994" "volumen" => "78" "paginaInicial" => "938" "paginaFinal" => "942" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8160994" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0510" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anesthesia considerations during cytoreductive surgery and hyperthermic intraperitoneal chemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "K.P. Rothfield" 1 => "K. Crowley" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.soc.2012.07.003" "Revista" => array:6 [ "tituloSerie" => "Surg Oncol Clin N Am" "fecha" => "2012" "volumen" => "21" "paginaInicial" => "533" "paginaFinal" => "541" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23021714" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0515" "etiqueta" => "49" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The use of cardiac output monitoring to guide the administration of intravenous fluid during hyperthermic intraperitoneal chemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K. Thaigainami" 1 => "F. Mohamed" 2 => "T. Cecil" 3 => "B.J. Moran" 4 => "J. Bell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/codi.12444" "Revista" => array:6 [ "tituloSerie" => "Colorectal Dis" "fecha" => "2013" "volumen" => "15" "paginaInicial" => "1537" "paginaFinal" => "1542" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24119169" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0520" "etiqueta" => "50" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Should the treatment of peritoneal carcinomatosis by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy still be regarded as a highly morbid procedure? A systematic review of morbidity and mortality" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T.C. Chua" 1 => "T.D. Yan" 2 => "A. Saxena" 3 => "D.L. Morris" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/SLA.0b013e3181a45d86" "Revista" => array:6 [ "tituloSerie" => "Ann Surg" "fecha" => "2009" "volumen" => "249" "paginaInicial" => "900" "paginaFinal" => "907" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19474692" "web" => "Medline" ] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0525" "etiqueta" => "51" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current status of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinomatosis from colorectal cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T. Weber" 1 => "M. Roitman" 2 => "K. Link" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clcc.2012.01.001" "Revista" => array:6 [ "tituloSerie" => "Clin Colorectal Cancer" "fecha" => "2012" "volumen" => "11" "paginaInicial" => "167" "paginaFinal" => "176" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22397952" "web" => "Medline" ] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0530" "etiqueta" => "52" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Severe hyponatremia, hyperglycemia, and hyperlactatemia are associated with intraoperative hyperthermic intraperitoneal chemo perfusion with oxaliplatin" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. De Somer" 1 => "W. Ceelen" 2 => "J. Delanghe" 3 => "D. de Smet" 4 => "M. Vanackere" 5 => "P. 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Evaluación preanestésica cardiovascular en cirugía oncológica

Paula Andrea Gómez-Henaoa,

Corresponding author

paugomezh@gmail.com

Corresponding author at: Department of Anesthesia, Instituto Nacional de Cancerología, Calle 1 N° 9-85, Bogotá, Colombia.

, José Alexander Carreño-Dueñasb

a Anesthesiologist, Anesthesiology and Resuscitation Department, Instituto Nacional de Cancerología, Bogotá, Colombia

b Researcher Physician, Research Area Group, Instituto Nacional de Cancerología, Bogotá, Colombia

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with an incidence of around 70&#44;887 new cases per year&#44; according to the estimates from 2000 to 2006 &#40;32&#44;316 cases in males and 38&#44;571 cases in females&#41;&#46; In men&#44; the main cancer sites were in order of importance&#58; prostate&#44; stomach&#44; lung&#44; rectum and non-Hodgkin lymphomas&#46; In women&#44; the most common sites were&#58; breast&#44; cervix&#44; thyroid&#44; stomach&#44; colon&#44; rectum and anus&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">1</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Definition</span><p id="par0015" class="elsevierStylePara elsevierViewall">Pre-anesthesia evaluation as part of the anesthetic procedure is defined as the process of clinical evaluation that precedes surgery and the administration of anesthesia&#46; Such evaluation comprises the information collected from multiple sources&#44; including the patient&#39;s medical record&#44; the interview&#44; the physical examination&#44; lab tests&#44; and inter-consultation with other specialities&#46;<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The main goal of pre-anesthesia evaluation is to assess any potential cardiovascular risks that may arise in the course of surgery&#44; collecting all the information required on the extension and stability cardiovascular disease&#44; if any&#44; or any cardiovascular risk factors&#44; understanding the scope of the procedure in order to adopt strategies that help to mitigate risks&#44; as well as any short and long term adverse outcomes&#46;<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">4&#8211;7</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The specific characteristics of the disease&#44; the social conditions&#44; and even the healthcare coverage have generated a new challenge for the cardiovascular management of cancer patients&#46; The higher survival rates and access to healthcare are additional considerations in the management of patients&#46; Aging and age-related physiological and pathological changes have led to new approaches to the cardiovascular management strategy in the elderly population&#44; with emphasis on age as an independent risk factor for perioperative morbidity and mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">8&#8211;11</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In accordance with <span class="elsevierStyleItalic">The National Confidential Enquiry Into Patient&#44; Outcome and Death &#40;NCPOD&#41;</span>&#44; most surgeries in cancer patients are a high priority and hence should not be delayed<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">12</span></a>&#59; however&#44; notwithstanding the availability of pre-anesthesia evaluation guidelines&#44; these procedures are often delayed due to inadequate approaches or unnecessary pre-surgical testing&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The cancer patient is a challenge for the anesthesiologist due to all the factors involved&#44; such as the exposure to chemotherapeutic agents or radiation therapy and the consequences thereof&#46; Cardiotoxicity is one of the most relevant complications of cancer chemotherapy that affects patients and increases with age&#59; cardiotoxicity may show gender differences&#46; The oncological approach and the management of cancer patients should be a joint effort between clinical oncology and cardiology&#46; Very often the cardiovascular risk is underestimated in cancer patients and these patients will usually undergo cancer surgery and then cardiovascular surgery&#46;<a class="elsevierStyleCrossRefs" href="#bib0335"><span class="elsevierStyleSup">13&#8211;16</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">This paper was intended to review the literature and consider new approaches to pre-anesthesia cardiovascular evaluation of cancer patients&#44; in order to reassess the current approaches used at referral centers&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Methodology</span><p id="par0045" class="elsevierStylePara elsevierViewall">A literature review was completed searching English and Spanish articles published since 1995&#44; using the following keywords neoplasm&#44; cancer centers&#44; medical oncology&#44; anesthesia&#44; anesthesia recovery period&#44; cardiovascular diseases with combinations including <span class="elsevierStyleItalic">AND&#44; OR&#44; ADJ&#44; NOT or NAND&#44; XOR</span>&#46; The major databases accessed were&#58; <span class="elsevierStyleItalic">PubMed&#44; OVID&#44; MedLine</span>&#44; <span class="elsevierStyleItalic">The Cochrane Library&#44; Embase</span>&#44; <span class="elsevierStyleItalic">Lilacs</span>&#46; Articles were selected on the basis of the title&#44; the abstract&#44; date of publication&#44; language and the relationship to the subject being reviewed&#46; &#40;The selection process is illustrated in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46;&#41;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Cardiovascular risk factors and cardiotoxicity of cancer patients</span><p id="par0050" class="elsevierStylePara elsevierViewall">Cardiovascular complications are becoming more evident as survival increases after the diagnosis and as a result of combined chemotherapy approaches&#46; It is important to emphasize that the selection of the chemotherapeutic agent and the survival prognosis depend on a fine balance between cancer treatment and cardiovascular therapy&#59; consequently&#44; notwithstanding the fact that cardiac monitoring is time-consuming and expensive&#44; it is nonetheless highly recommended&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Physiological aging is an independent risk factor for perioperative morbidity and mortality&#44; due to changes such as stiffness of the connective tissue that reduces the compliance of the veins&#44; the arteries and the myocardial tissue&#44; and leads to systolic hypertension&#44; increased afterload and myocardial hypertrophy&#46; Moreover&#44; a decreased beta-receptor response reduces the heart rate and the contractile response to hypotension&#44; to exertion and the exogenous administration of catecholamine&#46; Not to mention the cell loss at the sinoatrial node and subsequent heart rate disorders&#46; The ischemic pre-conditioning effect that protects against secondary infarction in extended &#8211; though not indefinite &#8211; ischemia&#44; seems to be absent in elderly patients and makes them more vulnerable to ischemic heart attacks&#46;<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">8&#8211;10</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In the long term&#44; cancer survivors have a high incidence of hypertension&#44; dyslipidemia&#44; acute coronary syndromes and acute CVAs&#44; in addition to the risk of chemotherapy exposure that is reported to be similar to smoking&#46; On top of the subsequent and concurrent exposure to a number of cardiovascular noxae&#44; the patient experiences lifestyle changes&#46; Usually&#44; upon learning about his&#47;her diagnosis&#44; the patient quits exercising&#44; tends to gain weight and to become depressed&#46; Depression is acknowledged as a new risk factor for coronary disease&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Pre-existing cardiovascular risk factors are strong predictors for later chemotherapy-mediated cardiotoxicity&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Thyroxin kinase inhibitors have been associated with hypertension and cardiotoxicity&#44; while the anti-vascular endothelial growth factor bevacizumab has been associated with pulmonary embolism&#44; pulmonary bleeding&#44; pulmonary edema and GI tract bleeding&#46; Other symptoms like hypotension or hypertension&#44; arrhythmias&#44; cardiac failure&#44; left ventricular dysfunction are seen in patients treated with monoclonal antibodies&#44; interleukins and alpha-interferon&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Other agents that seem to have an effect on the vascular system are the selective estrogen receptors modulators like tamoxifen that induces changes in the high and low-density lipoproteins&#46;<a class="elsevierStyleCrossRefs" href="#bib0335"><span class="elsevierStyleSup">13&#8211;16</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Some drugs such as anthracycline medications may lead to congestive heart failure and left ventricular dysfunction and is more frequently observed in women with heart disease&#46; Other antimetabolite agents such as capecitabine or citarabine may cause ischemia&#44; pericarditis&#44; heart failure&#44; and cardiogenic shock&#46;<a class="elsevierStyleCrossRefs" href="#bib0555"><span class="elsevierStyleSup">19&#8211;21</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Cardiotoxicity from fluoropiridines such as 5-fluorouracil is expressed as myocardial ischemia that is evidenced in the electrocardiographic tracing&#46; Antimicrotubular molecules such as paclitaxel or the vinca alkaloids are involved in sinus bradycardia&#44; AV block&#44; ventricular tachycardia&#44; hypotension&#44; heart failure and ischemia&#46;<a class="elsevierStyleCrossRefs" href="#bib0570"><span class="elsevierStyleSup">22&#8211;25</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Sub-endocardial fibrosis secondary to carcinoid heart or tumor infiltration that typically causes thickening of the tricuspid and pulmonary valves is found in up to 60&#37; of the patients with carcinoid heart&#46; Although valve regurgitation is the usual outcome&#44; stenosis may also occur&#46; Valve disease on its own&#44; associated with endocardial fibrosis&#44; finally results in right ventricular failure and death&#46; Extension of the disease is less common to the left side of the heart&#44; though the echocardiographic detection of a drop in the left ventricular ejection fraction is suggestive of endocardic fibrosis extending into the left heart&#46;<a class="elsevierStyleCrossRefs" href="#bib0545"><span class="elsevierStyleSup">17&#44;18</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Radiation therapy to the mediastinum has been associated with myocardial fibrosis&#44; left heart valve disease&#44; and endothelial cell damage&#46;<a class="elsevierStyleCrossRefs" href="#bib0400"><span class="elsevierStyleSup">26&#44;27</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Preoperative evaluation</span><p id="par0100" class="elsevierStylePara elsevierViewall">Morbidity during the perioperative period is directly related to underlying surgical pathology&#44; the patient&#39;s comorbidities&#44; the extent of surgery&#44; and the age-related physiological reserve&#44; as established under the <span class="elsevierStyleItalic">American Heart Association &#40;AHA&#41;</span> or the European Guidelines&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Cardiac death and non-fatal MI are associated with major surgeries such as surgery over the aorta&#44; major vascular surgery&#44; and peripheral vascular surgery with a mortality that exceeds 5&#37;&#46; Intermediate risk surgeries exhibit mortality rates ranging from 1&#37; to 5&#37;&#46; These include intraperitoneal and intrathoracic surgery&#44; carotid endarterectomy&#44; head and neck surgery&#44; orthopedic surgery and prostate surgery&#46; Finally&#44; the low risk surgeries with a risk of death below 1&#37; include endoscopic procedures&#44; cataract surgery&#44; breast surgery&#44; superficial and outpatient procedures&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">The functional status is another item in the pre-anesthesia cardiovascular evaluation&#46; It is easily measured through the performance of everyday activities in metabolic equivalents that are extrapolated according to the physical activity that the patient is able to perform&#44; based on pre-established targets under the American and European Guidelines&#46;<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">A number of mortality predictors have been developed throughout the years for the coronary patient undergoing non-coronary surgery that are constantly used for pre-anesthesia evaluations such as the Goldman index&#44; the revised Lee cardiac index&#44; Detsky score or modified Goldman&#44; and the Boersma&#44; among others&#46; These indexes summarize the patient&#39;s comorbidities and the level of compensation&#44; age as an independent risk factor and the functional class&#46;<a class="elsevierStyleCrossRefs" href="#bib0410"><span class="elsevierStyleSup">28&#8211;30</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Despite the identification of risk factors in the cancer patient&#44; including any pre-existing risk factors before the onset of cancer &#8211; i&#46;e&#46;&#44; hypertension&#44; dislipidemia&#44; diabetes&#44; etc&#46; &#8211; and those derived from cancer as a systemic disease and from cancer treatment&#44; there are few convincing data to predict which patients will develop chemotherapy-related cardiotoxicity&#46; Systolic dysfunction seems to be the most common manifestation&#44; though diastolic dysfunction may also be found&#46; Once the dysfunction occurs&#44; its progression is almost unavoidable and mortality is high&#46; So a lot of emphasis is placed on early detection of systolic dysfunction in patients undergoing chemotherapy&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Cancer treatment causes endothelial dysfunction and thus accelerates the atherosclerotic process&#44; leading to an increased risk of developing cardiovascular events later in life&#46; Early identification of cancer patients at high risk of developing cardiovascular events continues to be the key strategy to reduce morbidity and mortality&#59; however&#44; there are no recommendations at present in that regard&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Ejection fraction is one of the most important predictors in the prognosis of patients undergoing chemotherapy and radiotherapy at high risk of developing cardiotoxicity&#46; However&#44; the ejection fraction is a low sensitivity tool during the early stages of cardiotoxicity&#59; moreover&#44; a normal left ventricular ejection fraction does not rule out the potential for later decline&#46; Magnetic resonance is the gold standard for evaluating cardiac volume&#44; cardiac mass&#44; and systolic and diastolic function&#59; however&#44; the cost or MRI is high and its availability is limited&#46; Troponins have been used as biomarkers for acute cardiotoxicity&#44; in combination with natriuretic peptides&#44; but there is no evidence as to the role they play&#44; except when the heart damage is already established&#46; Troponins are highly sensitive to identify minor necrosis&#46; In every clinical context&#44; troponins do not only allow for the identification of myocardial damage&#44; but they are also used as a tool to stratify cardiac risk&#46; In fact&#44; high sensitivity troponins may be particularly useful in cardiotoxicity from chemotherapeutic agents&#44; but further studies are needed to determine their accuracy&#46; In terms of endothelial damage&#44; endothelial damage markers such as endogenous nitric oxide inhibitors and symmetric&#47;asymmetric dimethyl arginines have been measured and identified after several years&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Other measurements such as the thickening of the intima of the carotid have also been used as markers of endothelial damage&#46; Early detection of decreased left ventricle contractility using dobutamine stress echocardiography is another option for the early detection of a decline in ejection fraction following high doses of chemotherapy&#44; even at early stages before being identified with conventional echocardiography l&#46;<a class="elsevierStyleCrossRefs" href="#bib0425"><span class="elsevierStyleSup">31&#8211;38</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conclusion</span><p id="par0140" class="elsevierStylePara elsevierViewall">These patients represent a new challenge for referral cancer centers and for the multidisciplinary teams managing these patients&#46; Anesthesiologists have to deal with a top priority surgery&#44; in patients with multiple cardiovascular risk factors since a large percentage of these patients are 65 or older&#46; The risk of the procedure alone is at a 5&#37; level &#40;intermediate risk&#41; in terms of perioperative morbidity and mortality&#44; in addition to the exposure to chemotherapeutic cardiotoxic agents or radiation therapy in a large proportion of these patients&#46;</p><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">To what extent shall we stratify these patients in terms of their cardiovascular risk&#63;</span><p id="par0145" class="elsevierStylePara elsevierViewall">It is clear that cancer behaves as a systemic disease that affects all kinds of people and requires a multidisciplinary approach&#46; It is highly recommended that cancer centers become aware of the need to involve the cardiologist during the treatment of cancer and integrate cardio-oncology teams to manage and monitor these patients&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">The pre-anesthesia evaluation should consider cardiovascular evaluation a priority&#46; Extrapolating the guidelines for coronary patients to non-cardiac surgery is difficult because of the nature of the disease&#44; the cytoreduction process involved and the rate at which the disease stage may progress&#46; Naturally&#44; every coronary risk factor should be controlled&#44; but to what extent should a patient undergo cancer surgery when uncontrolled risk factors for coronary disease are present&#63;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Past studies have shown that prophylactic myocardial revascularization does not improve survival and is only an option for patients with unstable coronary syndromes and advanced coronary disease that do benefit from the procedure&#46;<a class="elsevierStyleCrossRefs" href="#bib0465"><span class="elsevierStyleSup">39&#8211;45</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">Surgical procedures such as Sugar Baker&#39;s&#44; inter alia&#44; with the multiple physiological variables that have to be controlled&#44; entail more than an intermediate risk and may even be considered major surgeries with adverse cardiac outcomes that deserve complementary studies and specific stratification to rule out coronary disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0500"><span class="elsevierStyleSup">46&#8211;54</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">Cardiovascular risk factors should be closely controlled&#44; particularly in patients that will later be transferred to the ICU&#46; We should then include exposure to chemotherapy or radiation therapy in the list of risk factors for this population&#44; together with strategies for prevention&#44; detection&#44; and treatment for cardiotoxicity resulting from both chemo and radiation therapy&#46; Consequently&#44; patients with predictors of intermediate risk that have been exposed to cycles of mediastinal chemotherapy or radiotherapy and will undergo intermediate risk cancer surgery should at least present with a left ventricle ejection fraction evaluation combined with biomarkers&#46; Is it necessary to evaluate the myocardial reserve in these patients&#63;</p><p id="par0170" class="elsevierStylePara elsevierViewall">There are still several unanswered questions about the perioperative cardiovascular evaluation of the patient undergoing cancer surgery&#46; Though the answers may seem obvious&#44; this is not usually the case in everyday practice&#46; Further studies are needed to be able to address these concerns and provide strong guidance for the pre-anesthesia evaluation and perioperative cardiovascular care of the surgical cancer patient&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Funding</span><p id="par0175" class="elsevierStylePara elsevierViewall">The authors did not receive sponsorship to undertake this article&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conflicts of interest</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Any cancer patient is a challenge for the anesthesiologist due to the increased cardiovascular risk factors resulting from the patient&#39;s condition&#44; in addition to the increased toxicity from chemotherapy&#46; Pre-anesthesia evaluation as part of the anesthetic activity is defined as the process of clinical evaluation before surgery and the administration of anesthesia per se&#46; This review is intended to reassess the current approach to cardiovascular pre-anesthesia evaluation in cancer patients at referral centers&#46; The search strategy used the major databases in the scientific literature&#44; based on the keywords identified&#46; The conclusion is that cardiovascular risk factors must be closely controlled and hence the approach to the management of the cancer patient should be in cooperation with clinical oncology and cardiology&#46; The evaluation should include the ejection fraction as one of the most relevant predictors of the patient&#39;s prognosis&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El paciente con c&#225;ncer representa un desaf&#237;o para el anestesi&#243;logo debido a los factores de riesgo cardiovascular incrementados por su condici&#243;n y a una mayor toxicidad por la quimioterapia que recibe&#46; La evaluaci&#243;n preanest&#233;sica como parte del acto anest&#233;sico se define como el proceso de valoraci&#243;n cl&#237;nica que precede al acto quir&#250;rgico en el que se suministra anestesia&#46; El objetivo de la presente revisi&#243;n es replantear la manera como actualmente se est&#225; enfocando la evaluaci&#243;n pre-anest&#233;sica cardiovascular en los pacientes oncol&#243;gicos en centros de referencia&#46; La estrategia de b&#250;squeda se realiz&#243; en las principales bases de datos con la b&#250;squeda de literatura cient&#237;fica de acuerdo a palabras clave definidas&#46; Como recomendaciones se concluye que los factores de riesgo cardiovascular se deben controlar en lo posible y por esto el enfoque y manejo oncol&#243;gico del paciente deber&#237;a hacerse en conjunto con las especialidades de oncolog&#237;a cl&#237;nica y cardiolog&#237;a&#46; Se deber&#237;a incluir la fracci&#243;n de eyecci&#243;n en esta valoraci&#243;n como uno de los predictores m&#225;s importantes para el pron&#243;stico de los pacientes&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; G&#243;mez-Henao PA&#44; Due&#241;as JAC&#46; Evaluaci&#243;n preanest&#233;sica cardiovascular en cirug&#237;a oncol&#243;gica&#46; Rev Colomb Anestesiol&#46; 2016&#59;44&#58;17&#8211;22&#46;</p>"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Practice advisory for preanesthesia evaluation&#46; An update report for the American Society of Anesthesiologists&#58; Task force on preanesthesia evaluation"
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                            1 => "J&#46;L&#46; Apfelbaum"
                            2 => "R&#46;T&#46; Connis"
                            3 => "D&#46;G&#46; Nickinovich"
                            4 => "American Society of Anesthesiologists Task Force on Preanesthesia Evaluation"
                            5 => "L&#46;R&#46; Pasternak"
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                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1097/ALN.0b013e31823c1067"
                      "Revista" => array:6 [
                        "tituloSerie" => "Anesthesiology"
                        "fecha" => "2012"
                        "volumen" => "116"
                        "paginaInicial" => "522"
                        "paginaFinal" => "538"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22273990"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Preoperative medical consultations&#58; impact of perioperative management and surgical outcome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;I&#46; Katz"
                            1 => "L&#46; Cimino"
                            2 => "S&#46;A&#46; Vitkun"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF03016556"
                      "Revista" => array:6 [
                        "tituloSerie" => "Can J Anaesth"
                        "fecha" => "2005"
                        "volumen" => "52"
                        "paginaInicial" => "697"
                        "paginaFinal" => "702"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16103381"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A survey on the intended purposes and perceived utility of preoperative cardiology consultations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46;I&#46; Katz"
                            1 => "J&#46;M&#46; Barnhart"
                            2 => "G&#46; Ho"
                            3 => "D&#46; Hersch"
                            4 => "S&#46;S&#46; Dayan"
                            5 => "L&#46; Keehn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Anesth Analg"
                        "fecha" => "1998"
                        "volumen" => "87"
                        "paginaInicial" => "830"
                        "paginaFinal" => "836"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9768778"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0295"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "2009 ACCF&#47;AHA focused update on periopertaive beta blocked incorporated into the ACC&#47;AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery preoperative cardiovascular assessment in non-cardiac surgery"
                      "autores" => array:1 [
                        0 => array:2 [
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                          "autores" => array:6 [
                            0 => "L&#46;A&#46; Fleisher"
                            1 => "J&#46;A&#46; Beckman"
                            2 => "K&#46;A&#46; Brown"
                            3 => "H&#46; Calkins"
                            4 => "E&#46;L&#46; Chaikof"
                            5 => "K&#46;E&#46; Fleischmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2009.07.010"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2009"
                        "volumen" => "54"
                        "paginaInicial" => "e13"
                        "paginaFinal" => "e118"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19926002"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiovascular aging and anesthetic implications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46;A&#46; Rooke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cardiothorac Vasc Anesth"
                        "fecha" => "2003"
                        "volumen" => "17"
                        "paginaInicial" => "512"
                        "paginaFinal" => "523"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12968244"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Preoperative evaluation of patients with&#44; or at risk of&#44; coronary artery disease undergoing non-cardiac surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;G&#46; Chassot"
                            1 => "A&#46; Delabays"
                            2 => "D&#46;R&#46; Spahn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Anaesth"
                        "fecha" => "2002"
                        "volumen" => "89"
                        "paginaInicial" => "747"
                        "paginaFinal" => "759"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12393774"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diastolic dysfunction in the older heart"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L&#46; Groban"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cardiothorac Vasc Anesth"
                        "fecha" => "2005"
                        "volumen" => "19"
                        "paginaInicial" => "228"
                        "paginaFinal" => "236"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15868536"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Spectrum of heart failure in older patients&#58; results from the National Heart Failure Project"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E&#46;P&#46; Havranek"
                            1 => "F&#46;A&#46; Masoudi"
                            2 => "K&#46;A&#46; Westfall"
                            3 => "P&#46; Wolfe"
                            4 => "D&#46;L&#46; Ordin"
                            5 => "H&#46;M&#46; Krumholz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "2002"
                        "volumen" => "143"
                        "paginaInicial" => "412"
                        "paginaFinal" => "417"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11868045"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relative importance of preoperative health status versus intraoperative factors predicting postoperative adverse outcomes in geriatric surgical patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;M&#46; Leug"
                            1 => "S&#46; Dzankic"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Geriatr Soc"
                        "fecha" => "2001"
                        "volumen" => "49"
                        "paginaInicial" => "1080"
                        "paginaFinal" => "1085"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11555070"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0590"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Knowing the risk&#58; a review of the perioperative care of surgical patients A report by the National confidential Enquiry into Patient Outcome and Death"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46;P&#46; Findlay"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:1 [
                        "fecha" => "2011"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0330"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiotoxicity of anticancer drugs&#58; the need for cardio-oncology and cardio-oncological prevention"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Albini"
                            1 => "G&#46; Pennesi"
                            2 => "F&#46; Donatelli"
                            3 => "R&#46; Cammarota"
                            4 => "S&#46; De Flora"
                            5 => "D&#46;M&#46; Noonan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/jnci/djp440"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Natl Cancer Inst"
                        "fecha" => "2010"
                        "volumen" => "102"
                        "paginaInicial" => "14"
                        "paginaFinal" => "25"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20007921"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0335"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiovascular complications of cancer therapy&#58; diagnosis&#44; pathogenesis&#44; and management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;T&#46; Yeh"
                            1 => "A&#46;T&#46; Tong"
                            2 => "D&#46;J&#46; Lenihan"
                            3 => "S&#46;W&#46; Yusuf"
                            4 => "J&#46; Swafford"
                            5 => "C&#46; Champion"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.CIR.0000133187.74800.B9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2004"
                        "volumen" => "109"
                        "paginaInicial" => "3122"
                        "paginaFinal" => "3131"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15226229"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0340"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiotoxicity of chemotherapeutic agents&#58; incidence&#44; treatment and prevention"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "V&#46;B&#46; Pai"
                            1 => "M&#46;C&#46; Nahata"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Drug Saf"
                        "fecha" => "2000"
                        "volumen" => "22"
                        "paginaInicial" => "263"
                        "paginaFinal" => "302"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10789823"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0345"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chemotherapy and cardiotoxicity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Broder"
                            1 => "R&#46; Gottlieb"
                            2 => "N&#46; Lepor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Cardiovasc Med"
                        "fecha" => "2008"
                        "volumen" => "9"
                        "paginaInicial" => "75"
                        "paginaFinal" => "83"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18660728"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carcinoid tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Kulke"
                            1 => "R&#46; Mayer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199903183401107"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1999"
                        "volumen" => "340"
                        "paginaInicial" => "858"
                        "paginaFinal" => "868"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10080850"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0545"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiovascular manifestation of endocryne dysfunction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;J&#46; Deegan"
                            1 => "W&#46;R&#46; Furman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.jvca.2010.12.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cardiothorac Vasc Anesth"
                        "fecha" => "2011"
                        "volumen" => "25"
                        "paginaInicial" => "705"
                        "paginaFinal" => "720"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21330154"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0550"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardioprotective interventions for cancer patients receiving anthracyclines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46;C&#46; Van Dalen"
                            1 => "H&#46;N&#46; Caron"
                            2 => "H&#46; Dickinson"
                            3 => "L&#46;C&#46; Kremer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Cochrane Database Syst Rev"
                        "fecha" => "2005"
                        "paginaInicial" => "CD003917"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0555"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Congestive heart failure and left ventricular dysfunction complicating doxorubicine therapy&#46; Seven years experience using serial radionuclide angiocardiography"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46;G&#46; Schwarts"
                            1 => "W&#46;B&#46; McKenzie"
                            2 => "J&#46; Alexander"
                            3 => "P&#46; Sager"
                            4 => "A&#46; D&#39;Souza"
                            5 => "A&#46; Manatunga"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "1987"
                        "volumen" => "82"
                        "paginaInicial" => "1109"
                        "paginaFinal" => "1118"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3605130"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0560"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Simbre II IV&#44; Adams MJ&#44; Deshpande SS&#44; Duffy SA&#44; Miller TL&#44; Lipshultz SE&#46; Cardiomyopathy caused by antineoplastic therapies&#46; Curr Treat Options Cardiovas Med&#46; 2001&#59;3&#58;493&#8211;505&#46;"
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0565"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prophylactic options in patients with 5-fluorouracil associated cardiotoxicity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Cianci"
                            1 => "M&#46;F&#46; Morelli"
                            2 => "K&#46; Cannita"
                            3 => "R&#46; Morese"
                            4 => "E&#46; Ricevuto"
                            5 => "Z&#46;C&#46; Di Rocco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.bjc.6600967"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Cancer"
                        "fecha" => "2003"
                        "volumen" => "88"
                        "paginaInicial" => "1507"
                        "paginaFinal" => "1509"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12771913"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0570"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac dysfunction in the traztuzumab clinical trials experience"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Seidman"
                            1 => "C&#46; Hudis"
                            2 => "M&#46;K&#46; Pierri"
                            3 => "S&#46; Shak"
                            4 => "V&#46; Paton"
                            5 => "M&#46; Ashby"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/jco.2002.20.5.1215"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "2002"
                        "volumen" => "20"
                        "paginaInicial" => "1215"
                        "paginaFinal" => "1221"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11870163"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0575"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hormonal therapy use for prostate cancer and mortality in men with coronary artery disease-induced congestive heart failure or myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Nanda"
                            1 => "M&#46;H&#46; Chen"
                            2 => "M&#46;H&#46; Braccioforte"
                            3 => "B&#46;J&#46; Moran"
                            4 => "A&#46;V&#46; D&#8217;Amico"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.2009.1137"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2009"
                        "volumen" => "302"
                        "paginaInicial" => "866"
                        "paginaFinal" => "873"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19706860"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0580"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Statins and cancer&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Kuoppala"
                            1 => "A&#46; Lamminpaa"
                            2 => "E&#46; Pukkala"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ejca.2008.06.025"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Cancer"
                        "fecha" => "2008"
                        "volumen" => "44"
                        "paginaInicial" => "2122"
                        "paginaFinal" => "2132"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18707867"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0585"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "American Society of Clinical Oncology Chemotherapy and Radiotherapy Expert Panel&#46; 2002 update of recommendations for the use of chemotherapy and radiotherapy protectants&#58; clinical practice guidelines of the American society of clinical oncology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;M&#46; Schucter"
                            1 => "M&#46;L&#46; Hensley"
                            2 => "N&#46;J&#46; Meropol"
                            3 => "E&#46;P&#46; Winwer"
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                    0 => array:2 [
                      "doi" => "10.1200/JCO.2002.04.178"
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                        "tituloSerie" => "J Clin Oncol"
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                        "volumen" => "20"
                        "paginaInicial" => "2895"
                        "paginaFinal" => "2903"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12065567"
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              "identificador" => "bib0400"
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                    0 => array:2 [
                      "titulo" => "Cardiac effects of radiation therapy and chemotherapy"
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                          "autores" => array:2 [
                            0 => "D&#46;S&#46; Rosenthal"
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                        "paginaFinal" => "1751"
                        "serieFecha" => "2001"
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            26 => array:3 [
              "identificador" => "bib0405"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Derivation and prospective validation of a simple index for prediction of cardiac risk of major no cardiac surgery"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46;H&#46; Lee"
                            1 => "E&#46;R&#46; Marcantonio"
                            2 => "C&#46;M&#46; Mangione"
                            3 => "E&#46;J&#46; Thomas"
                            4 => "C&#46;A&#46; Polanczyk"
                            5 => "E&#46;F&#46; Cook"
                          ]
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1999"
                        "volumen" => "100"
                        "paginaInicial" => "1043"
                        "paginaFinal" => "1049"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10477528"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0410"
              "etiqueta" => "28"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predicting cardiac complications in patients undergoing non-cardiac surgery"
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;S&#46; Destky"
                            1 => "H&#46;B&#46; Abraham"
                            2 => "J&#46;R&#46; McLaughlin"
                            3 => "D&#46;J&#46; Drucker"
                            4 => "Z&#46; Sasson"
                            5 => "N&#46; Johnston"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Gen Intern Med"
                        "fecha" => "1986"
                        "volumen" => "1"
                        "paginaInicial" => "211"
                        "paginaFinal" => "219"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3772593"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0415"
              "etiqueta" => "29"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The prognosis value of exercise capacity&#58; a review of the literature"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;K&#46; Morris"
                            1 => "K&#46; Ueshima"
                            2 => "T&#46; Kawaguchi"
                            3 => "A&#46; Hideg"
                            4 => "V&#46;F&#46; Froelicher"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1991"
                        "volumen" => "122"
                        "paginaInicial" => "1423"
                        "paginaFinal" => "1431"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1951007"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            29 => array:3 [
              "identificador" => "bib0420"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognostic value of troponin I in cardiac risk stratification of cancer patients undergoing high -dose chemotherapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Cardinale"
                            1 => "M&#46; Sandri"
                            2 => "A&#46; Colombo"
                            3 => "M&#46; Boeri"
                            4 => "G&#46; Lamantia"
                            5 => "M&#46; Civelli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.CIR.0000130926.51766.CC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2004"
                        "volumen" => "109"
                        "paginaInicial" => "2749"
                        "paginaFinal" => "2754"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15148277"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0425"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "N-terminal pro-B-type natriuretic peptide after high-dose chemotherapy&#58; a marker predictive of cardiac dysfunction&#63;"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "M&#46; Salvatici"
                            2 => "D&#46; Cardinale"
                            3 => "L&#46; Zorzino"
                            4 => "R&#46; Passerini"
                            5 => "P&#46; Lentati"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1373/clinchem.2005.050153"
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                        "tituloSerie" => "Clin Chem"
                        "fecha" => "2005"
                        "volumen" => "51"
                        "paginaInicial" => "1405"
                        "paginaFinal" => "1410"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15932966"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0430"
              "etiqueta" => "32"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biochemical markers for prediction of chemotherapy-induced cardiotoxicity&#58; systematic review of the literature and recommendations for use"
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                          "etal" => false
                          "autores" => array:5 [
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                            2 => "D&#46; Cardinale"
                            3 => "M&#46;T&#46; Sandri"
                            4 => "M&#46; Panteghini"
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                    0 => array:2 [
                      "doi" => "10.1309/AJCPB66LRIIVMQDR"
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                        "tituloSerie" => "Am J Clin Pathol"
                        "fecha" => "2008"
                        "volumen" => "130"
                        "paginaInicial" => "688"
                        "paginaFinal" => "695"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18854260"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0435"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biomarkers in heart failure"
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                          "etal" => false
                          "autores" => array:1 [
                            0 => "E&#46; Braunwald"
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                        "tituloSerie" => "N Engl J Med"
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                        "volumen" => "358"
                        "paginaInicial" => "2148"
                        "paginaFinal" => "2159"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18480207"
                            "web" => "Medline"
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              "identificador" => "bib0440"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early reduction in left ventricular contractile reserve detected by dobutamina stress echo predicts high dose chemotherapy induced cardiac toxicity"
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                          "etal" => true
                          "autores" => array:6 [
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                            1 => "D&#46; Cardinale"
                            2 => "A&#46; Martinoni"
                            3 => "G&#46; Lamantia"
                            4 => "N&#46; Colombo"
                            5 => "A&#46; Colombo"
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijcard.2005.07.029"
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                        "tituloSerie" => "Int J Cardiol"
                        "fecha" => "2006"
                        "volumen" => "111"
                        "paginaInicial" => "120"
                        "paginaFinal" => "126"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16242796"
                            "web" => "Medline"
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                ]
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              "identificador" => "bib0445"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Strategies to prevent and treat cardiovascular risk in cancer patients"
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                            4 => "C&#46;M&#46; Cipolla"
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                    0 => array:2 [
                      "doi" => "10.1053/j.seminoncol.2013.01.008"
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                        "tituloSerie" => "Semin Oncol"
                        "fecha" => "2013"
                        "volumen" => "40"
                        "paginaInicial" => "186"
                        "paginaFinal" => "198"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23540744"
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              "identificador" => "bib0450"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Cardiovascular disease in survivors of adolescent and young adult cancer&#58; a Danish Cohort Study"
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                          "etal" => false
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                            2 => "D&#46; Boice"
                            3 => "L&#46; Kober"
                            4 => "M&#46; Ewertz"
                            5 => "J&#46;H&#46; Olsen"
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                    ]
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                    0 => array:2 [
                      "doi" => "10.1093/jnci/dju061"
                      "Revista" => array:4 [
                        "tituloSerie" => "J Natl Cancer Inst"
                        "fecha" => "2014"
                        "volumen" => "106"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24681604"
                            "web" => "Medline"
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              "identificador" => "bib0455"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Prognostic value of routine cardiac magnetic resonance assessment of the left ventricular ejection fractioned myocardial damage&#58; an international&#44; multicenter study"
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                          "etal" => true
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                            2 => "R&#46;D&#46; White"
                            3 => "D&#46;J&#46; Pennell"
                            4 => "A&#46;C&#46; van Rossum"
                            5 => "M&#46; Regenfus"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/CIRCIMAGING.111.964965"
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                        "tituloSerie" => "Circ Cardiovasc Imaging"
                        "fecha" => "2011"
                        "volumen" => "4"
                        "paginaInicial" => "610"
                        "paginaFinal" => "619"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21911738"
                            "web" => "Medline"
                          ]
                        ]
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                    ]
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              ]
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              "identificador" => "bib0460"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Coronary artery revascularization before elective mayor vascular surgery"
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Mcfalls"
                            1 => "H&#46; Ward"
                            2 => "T&#46; Moritz"
                            3 => "S&#46; Goldman"
                            4 => "W&#46;C&#46; Krupski"
                            5 => "F&#46; Littooy"
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                    0 => array:2 [
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                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2004"
                        "volumen" => "351"
                        "paginaInicial" => "2795"
                        "paginaFinal" => "2804"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15625331"
                            "web" => "Medline"
                          ]
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              ]
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              "identificador" => "bib0465"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Disparate opinions regarding indications for coronary artery revascularization prior to elective vascular surgery"
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                            4 => "F&#46; Littooy"
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                    0 => array:2 [
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                        "paginaInicial" => "1124"
                        "paginaFinal" => "1128"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15518605"
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                    ]
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            39 => array:3 [
              "identificador" => "bib0470"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Catastrophic outcomes of non-cardiac surgery soon after coronary stenting"
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                            4 => "A&#46;E&#46; Raizner"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2000"
                        "volumen" => "35"
                        "paginaInicial" => "1288"
                        "paginaFinal" => "1294"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10758971"
                            "web" => "Medline"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Fatal myocardial infarction after lung resection in a patient with prophylactic preoperative coronary stenting"
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                            3 => "L&#46; Magnusson"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/bja/aeh110"
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                        "tituloSerie" => "Br J Anaesth"
                        "fecha" => "2004"
                        "volumen" => "92"
                        "paginaInicial" => "743"
                        "paginaFinal" => "747"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15003980"
                            "web" => "Medline"
                          ]
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                ]
              ]
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              "identificador" => "bib0480"
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                0 => array:2 [
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                      "titulo" => "Does preoperative coronary angioplasty improve perioperative cardiac outcome&#63;"
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                          "etal" => true
                          "autores" => array:6 [
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                            1 => "B&#46; Riou"
                            2 => "M&#46; Bertrand"
                            3 => "M&#46;H&#46; Fl&#233;ron"
                            4 => "J&#46;P&#46; Goarin"
                            5 => "G&#46; Montalescot"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Anesthesiology"
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                        "paginaInicial" => "739"
                        "paginaFinal" => "746"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15791102"
                            "web" => "Medline"
                          ]
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                ]
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              "identificador" => "bib0485"
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              "referencia" => array:1 [
                0 => array:2 [
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                        "link" => array:1 [
                          0 => array:2 [
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                            4 => "A&#46;T&#46; Ong"
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                        "paginaFinal" => "1521"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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                        "tituloSerie" => "J Thorac Cardiovasc Surg"
                        "fecha" => "2012"
                        "volumen" => "143"
                        "paginaInicial" => "780"
                        "paginaFinal" => "803"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22424518"
                            "web" => "Medline"
                          ]
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              ]
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                    0 => array:2 [
                      "titulo" => "Prospective morbidity and mortality assessment of cytoreductive surgery plus perioperative intraperitoneal chemotherapy to treat peritoneal dissemination of appendiceal mucinous malignancy"
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                          "etal" => true
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                            3 => "C&#46;E&#46; Marquardt"
                            4 => "V&#46; Gushchin"
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                        "tituloSerie" => "Ann Surg Oncol"
                        "fecha" => "2006"
                        "volumen" => "13"
                        "paginaInicial" => "635"
                        "paginaFinal" => "644"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16523363"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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                ]
              ]
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              "etiqueta" => "47"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Cardiovascular changes during continues hyperthermic peritoneal perfusion"
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                            0 => "N&#46; Shime"
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                            2 => "T&#46; Hatanaka"
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                    ]
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                  "host" => array:1 [
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                        "tituloSerie" => "Anesth Analg"
                        "fecha" => "1994"
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                        "paginaInicial" => "938"
                        "paginaFinal" => "942"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8160994"
                            "web" => "Medline"
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                ]
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                      "titulo" => "Anesthesia considerations during cytoreductive surgery and hyperthermic intraperitoneal chemotherapy"
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46;P&#46; Rothfield"
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                        "tituloSerie" => "Surg Oncol Clin N Am"
                        "fecha" => "2012"
                        "volumen" => "21"
                        "paginaInicial" => "533"
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                          "etal" => false
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                            4 => "J&#46; Bell"
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                        "paginaFinal" => "907"
                        "link" => array:1 [
                          0 => array:2 [
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                        "paginaFinal" => "66"
                        "link" => array:1 [
                          0 => array:2 [
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Article information

ISSN: 22562087
Original language: English

DOI:10.1016/j.rcae.2015.05.005

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Year/Month	Html	Pdf	Total

2024 November	11	1	12
2024 October	69	14	83
2024 September	48	10	58
2024 August	49	8	57
2024 July	37	5	42
2024 June	31	6	37
2024 May	43	10	53
2024 April	79	11	90
2024 March	51	6	57
2024 February	58	14	72
2024 January	67	11	78
2023 December	47	13	60
2023 November	45	6	51
2023 October	59	12	71
2023 September	34	10	44
2023 August	41	11	52
2023 July	43	7	50
2023 June	28	6	34
2023 May	53	16	69
2023 April	43	6	49
2023 March	26	12	38
2023 February	23	25	48
2023 January	24	23	47
2022 December	17	8	25
2022 November	30	14	44
2022 October	13	13	26
2022 September	9	10	19
2022 August	12	12	24
2022 July	25	12	37
2022 June	12	14	26
2022 May	13	9	22
2022 April	9	7	16
2022 March	9	8	17
2022 February	6	8	14
2022 January	22	19	41
2021 December	13	7	20
2021 November	13	11	24
2021 October	11	13	24
2021 September	5	10	15
2021 August	13	23	36
2021 July	6	4	10
2021 June	14	11	25
2021 May	11	8	19
2021 April	11	12	23
2021 March	16	25	41
2021 February	13	11	24
2021 January	6	6	12
2020 December	8	7	15
2020 November	5	3	8
2020 October	6	3	9
2020 September	10	8	18
2020 August	22	10	32
2020 July	5	9	14
2020 June	6	4	10
2020 May	8	2	10
2020 April	4	3	7
2020 March	7	1	8
2020 February	16	7	23
2020 January	8	2	10
2019 December	16	7	23
2019 November	7	2	9
2019 October	7	1	8
2019 September	8	3	11
2019 August	3	3	6
2019 July	3	7	10
2019 June	4	4	8
2019 May	5	11	16
2018 September	1	0	1
2018 June	6	1	7
2018 May	12	8	20
2018 April	22	6	28
2018 March	16	9	25
2018 February	5	5	10
2018 January	13	8	21
2017 December	11	7	18
2017 November	11	7	18
2017 October	13	17	30
2017 September	6	6	12
2017 August	5	6	11
2017 July	9	3	12
2017 June	8	6	14
2017 May	16	8	24
2017 April	22	12	34
2017 March	6	6	12
2017 February	6	5	11
2017 January	7	6	13
2016 December	17	19	36
2016 November	20	8	28
2016 October	17	13	30
2016 September	21	9	30
2016 August	29	10	39
2016 July	18	10	28
2016 June	1	0	1
2016 May	2	0	2
2016 March	1	0	1
2016 February	3	0	3

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