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25-Hydroxyvitamin D serum levels in rheumatic female patients in southeast Spain: The paradigm of daily optimal sunshine levels and inadequate vitamin D status
Concentraciones séricas de 25-hidroxivitamina D en mujeres reumáticas del sureste de España: el paradigma de los niveles diarios óptimos de luz solar y la insuficiencia de vitamina D
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Roldan" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Claudia Alejandra" "apellidos" => "Pereda" "email" => array:1 [ 0 => "cpereda@ser.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "María Betina" "apellidos" => "Nishishinya" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "Emilio J.A." "apellidos" => "Roldan" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Hospital Mediterráneo, Almería, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Instituto Traumatológico Quirón, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "MD Programme in Education and Sport Sciences, Facultat de Psicologia, Ciències de l’Educació i de l’Esport Blanquerna, Barcelona, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Scientific Direction, Gador SA, Buenos Aires, Argentina" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Concentraciones séricas de 25-hidroxivitamina D en mujeres reumáticas del sureste de España: el paradigma de los niveles diarios óptimos de luz solar y la insuficiencia de vitamina D" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1040 "Ancho" => 2080 "Tamanyo" => 74252 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Percentage of patients with vitamin D insufficiency according to age and season.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Insufficient exposure to sunlight is a worldwide known cause of vitamin D deficiency.<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">1</span></a> Essentially, the chief determinant of circulating vitamin D levels is the total amount of sunlight exposure absorbed by the skin, following solar ultraviolet radiation (UVR).<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">2</span></a> Besides, numerous investigations suggest that individual differences together with geographical and seasonal variances exert a critical influence on vitamin D status.<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Evidence of vitamin D beneficial effect on reducing the risk of different adverse health outcomes has been increasingly growing in the past years. Predominantly, there is data on bone health,<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">4,5</span></a> cancer,<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">6</span></a> autoimmune,<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">7</span></a> cardiovascular diseases<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">8</span></a> and recently in respiratory tract infections.<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">9</span></a> So far, the best marker of vitamin D status is circulating 25OHD concentration; though, there is no formal consensus on the optimal 25OHD serum values<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">10</span></a> and besides, what constitutes vitamin D deficiency is still troublesome.<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">11</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Almeria is a Spanish province, located in the extreme southeast of the country, receiving a mean well above the 240<span class="elsevierStyleHsp" style=""></span>h of sunlight per month, ranging from 176 to 336<span class="elsevierStyleHsp" style=""></span>h per year.<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">12</span></a> The region accumulates the highest amount of hours of daylight both in Spain, and in most European countries. The aim of our study, according to Almeria advantageous location, was to make out 25OHD serum status in a population with distinct rheumatic conditions according to age and season, to identify subgroups at risk of vitamin D deficiency, and evaluate the impact of long sunlight exposure in vitamin D sufficiency.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Patients and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Study design and study population</span><p id="par0020" class="elsevierStylePara elsevierViewall">This was a cross sectional study conducted between September 2008 and August 2014 in an outpatient rheumatology clinic in Almería province (located 36.5° latitude N, 2° LW).</p><p id="par0025" class="elsevierStylePara elsevierViewall">This geographical location benefits from optimal annual sunshine levels,<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">12</span></a> good air quality (particulate matter: 10 and real time quality index (AQI)<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>5; plus a very low precipitation rate (around 9, 4<span class="elsevierStyleHsp" style=""></span>mm/year).<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">13</span></a> Patients eligible for the study were women older than 18 years, able to walk, unaided, and not living in care institutions. Menopausal status was defined as when menstruation has failed to occur over a 12 month period while women whose status was uncertain and who replied that they had an unsettled menopause were classified as premenopausal.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Exclusion criteria comprised inflammatory rheumatic diseases, kidney, hepatic or bowel diseases, corticosteroid (oral or inhaled), and or vitamin D therapy. In order to capture information from several seasons and years, two days per week, patients attending this clinic were invited to take part. These were informed about the study and those who consent were included.</p><p id="par0035" class="elsevierStylePara elsevierViewall">The ethics committee of Hospital Mediterraneo approved the study protocol.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Measurements</span><p id="par0040" class="elsevierStylePara elsevierViewall">Blood samples were taken after an eight-hour fast. Vitamin D measurements were performed with ADVIA Centaur XP Vitamin D Total assay (Siemens Healthcare diagnostics) in external labs, obtaining hydroxylated form, 25OHD values were considered deficient (<20<span class="elsevierStyleHsp" style=""></span>ng/ml), insufficient (>20 and <30<span class="elsevierStyleHsp" style=""></span>ng/ml) and sufficient (≥30<span class="elsevierStyleHsp" style=""></span>ng/ml).<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">14</span></a> Calcium, phosphorous, creatinine, albumin, intact parathyroid hormone (PTH) serum levels were also determined. The date of collection was recorded. Seasons were divided according to standards in the northern hemisphere, winter spanning from December 22 to March 20, spring from March 21 to June 20, summer from June 21 to September 22 and fall from September 23 to December 21.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Daylight for the date of the 25OHD sample was obtained from the European weather website (<a id="intr0005" class="elsevierStyleInterRef" href="http://www.climatedata.eu/">http://www.climatedata.eu</a>),<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">12</span></a> and real time air quality index from (<a id="intr0010" class="elsevierStyleInterRef" href="http://www.aqicn.org/">http://www.aqicn.org</a>).<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">13</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Statistical analysis</span><p id="par0050" class="elsevierStylePara elsevierViewall">Patients were described according to the distribution of variables with summary statistics. Student's <span class="elsevierStyleItalic">t</span> test and analysis of variance were used to test hypotheses concerning different distributions by groups. Correlations between continuous variables were tested with the Pearson coefficient. Data were analyzed using Medcalc statistical software version 9.3.8.0 for Windows, with a confident interval of 95% and a significance level lower than 5% (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05).</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Results</span><p id="par0055" class="elsevierStylePara elsevierViewall">The study sample included 319 women, whose mean age was 53.2 (SD 11.1; range 18–81) all Caucasian. Two hundred and sixty women (81, 5%) were postmenopausal. The main diagnosis reported at the time of recruitment were fibromyalgia, osteoarthritis, osteoporosis/osteopenia, back pain, tendinitis, bursitis, shoulder impidgement and polyarthralgia (87%). Yet, major prevalent comorbidities were hypertension, followed by dyslipidaemia and dysthymia (20%, 8% and 12% respectively). Medications most frequently employed were antihypertensives and anxiolytics. <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> includes a description of the sample, total and by age groups. The mean 25OHD values were 30.2<span class="elsevierStyleHsp" style=""></span>g/ml (SD 16.2; range 6.0–96.1), with 80 (25.1%) samples considered deficient in vitamin D, 112 (35.1%) insufficient, and 127 (39.8%) sufficient.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">The evaluation of laboratory variables that could hamper with 25OHD status revealed no significant difference in hemoglobin, leukocytes, albumin, calcium, and phosphorus between age groups. PTH values were significantly higher in women above 60 years old compared to the other groups and hematocrit significantly lower in the youngest group (see <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><p id="par0065" class="elsevierStylePara elsevierViewall">Season was associated to the level of serum 25OHD (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001), with autumn being the only season in which highest levels of 25OHD serum levels were found (mean 36.8<span class="elsevierStyleHsp" style=""></span>ng/ml; SD<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>19.8) (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) with mean levels above 30<span class="elsevierStyleHsp" style=""></span>ng/ml in all bands. Conversely, the lowest mean 25OHD concentrations were found in winter, in all groups (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>, <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). All age groups exhibited mean 25OHD serum levels<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>ng/ml in summer, except for cohort between 54 and 60 years, but the difference between groups was not statistically significant. 25OHD serum levels followed normal distribution.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRefs" href="#fig0010">Figs. 2 and 3</a> display the percentage of patients reaching inadequate levels according to mean serum values of 25OHD, season and age bands. More than 40% of the patients younger than 48 years had vitamin D levels under the level of insufficiency in all seasons.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">The presence or absence of menopause did not make difference in 25OHD serum levels. Though significantly older, the menopause group exhibited a clear correlation between age and PTH levels (correlation coefficient <span class="elsevierStyleItalic">r</span>, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.036).</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discussion</span><p id="par0080" class="elsevierStylePara elsevierViewall">We have shown that two thirds of a sample of women in a sunny region are below sufficient levels of vitamin D. In point of fact, the hypothesized proper exposure to sunlight capacity to sustain adequate serum levels of vitamin D in female population appears not to be fully acceptable in view of the present results. Yet, previous research have drawn attention to sunlight exposure (UVR) as a critical step in vitamin D synthesis.<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">3</span></a> In addition to the number of sunlight hours, factors like latitude, season and time of the day, exert an important influence on UVR effectivity.<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">15</span></a> Yet, regions above 37° latitude N during winter result in very little if any vitamin D3 produced in the skin, while below 37° N more vitamin D3 synthesis occurs throughout the year.<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">1</span></a> Despite the fact of Almeria's adequate location and optimum level of sunshine throughout the year (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>), insufficient 25OHD serum levels prevailed both in winter and spring in middle-aged and elderly women. In this line, studies carried out in similar latitudes<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">16–18</span></a> at both sides of the equator achieved comparable seasonal upshots. For example, early studies performed in Buenos Aires, Argentina (latitude 34° S), reported a prevalence of vitamin D deficiency of up to 65% among ambulatory postmenopausal women during wintertime.<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">19</span></a> While in Geelong region, Australia (latitude 38° N) vitamin D insufficiency reached 38% in a female population under 60.<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">16</span></a> Season is known to be associated with ambient ultraviolet radiation, reaching its peak in summer and minimum in winter. In this respect, Almeria is outstanding, as the annual average hours of sunshine can reach 247.6<span class="elsevierStyleHsp" style=""></span>h, and 196.5<span class="elsevierStyleHsp" style=""></span>h throughout winter.<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">12</span></a> Conversely, cities in northern latitudes like Copenhagen (55.6° N) or London (51.5° N) are not exposed to more than 72.3<span class="elsevierStyleHsp" style=""></span>h of sunshine in winter.<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">12</span></a> Even so, an optimal level of sunshine throughout the year, does not guarantee acceptable levels of 25OHD as shown in our study. Perhaps, changes in outdoor behavior and increased clothing worn, together with decreased time spent outdoor mainly in both seasons, could explain in part these results.<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">16</span></a> On the other hand, autumn is the season in which 25OHD reached optimal serum levels in all ages. This finding is in full agreement with various other works, placing 25OHD annual peak in autumn and nadir in winter-spring.<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">20,21</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">These percentages of deficiency in our study were even higher than expected. In this regard Rodriguez Sangrador et al., <a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">22</span></a> drew attention to the fact that more than 50% of women patients in his trial avoided exposing to sunlight in summer. Similar results were displayed in studies located in Brazil,<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">23</span></a> Iran<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">24</span></a> and also in an interesting paper by Al-Daghri et al., in Saudi Arabia.<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">25</span></a> Regardless of the fact that these regions are well below 37° latitude S and N respectively, summer months present very high temperatures (>40<span class="elsevierStyleHsp" style=""></span>°C at noon) increasing risk of heat strokes. In this line, Almeria, also achieve high temperatures in summer (well >30<span class="elsevierStyleHsp" style=""></span>°C), possibly preventing patients >60 years in particular from exposing to sunlight, and therefore reducing outdoors activities. This is something to take into account, as summer has been traditionally defined as the season were Caucasians and some other skin types can make optimal vitamin D3.<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">26,27</span></a> Concerning younger population, unacceptable high insufficient levels, reaching >50%, extended to female patients below 48 and above 60 years old in the present study. Indeed, most trials describe the expected decrease in 25OHD during winter in young population, particularly in northern latitudes.<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">28,29</span></a> In this respect, Trangpricha et al. revealed that the prevalence of vitamin D deficiency increased from 3 to 30% between summer and winter in young healthy adults aged 18–29 years.<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">30</span></a> However, Gagnon et al., concluded that about a third of women of childbearing age have suboptimal serum 25OHD levels during summer.<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">28</span></a> Also, Gonzalez-Padilla et al., revealed that almost 2/3 of young healthy medicine students at University of Las Palmas of Gran Canarias Islands (28 N), had mean levels of 25OHD <30<span class="elsevierStyleHsp" style=""></span>ng/ml. Apart from reasons others than avoiding sunlight exposure and time spent indoors during summer, the use of sunscreen in all ages could exert additional influence in reducing 25OHD serum levels,<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">31</span></a> though this is still controversial.<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">32,33</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">We found that menopause did not exert particular influence on 25OHD serum levels along seasons. In contrast, previous reports suggest the prevalence of inadequate vitamin D levels in post-menopausal women, particularly in those with osteoporosis and history of fractures in northern latitudes.<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">34</span></a> Also, vitamin D deficiency was corroborated during menopause in studies performed in South America, despite their location at latitudes with abundant sunlight.<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">35</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">This study identified patients >60 years as being at higher risk of inadequate vitamin D serum levels (both insufficiency and deficiency). However, low 25OHD serum levels were also observed in the other age bands. These inadequacies extended not only to the winter-spring seasons, but also to summer period particularly in the eldest group. The decreased vitamin D status of elderly persons is well known, with numerous factors implicated including lack of dietary consumption, malabsorption, and what is most important, a reduction in 7-dehydrocholesterol (7-DHC) in the skin.<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">36</span></a> 7-DHC is a chemical precursor required for vitamin D synthesis, which decrease by nearly half from a 21-year-old to an 88-year-old.<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">15</span></a> However, the youngest group exhibited almost 60% insufficient 25OHD serum levels in winter, spring and 50% in summer, while deficient levels were not significant in this group.</p><p id="par0100" class="elsevierStylePara elsevierViewall">The main strengths of our study include its large sample size and low frequency of missing data.</p><p id="par0105" class="elsevierStylePara elsevierViewall">However, some limitations are worth noting. To begin with, all women included in the study were Caucasian, corresponding to skin photo type III–IV according to Fitzpatrick classification.<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">37</span></a> Therefore caution should be applied when extrapolating these results to the general population. Another limitation was the fact that body mass index was not included in clinical records. As Vitamin D3 is fat-soluble and store in body fat, we could have missed the magnitude of overweight subjects with vitamin D deficiency. Finally, we could not perform a detailed evaluation of vitamin D taken from the diet and obtain accurate data about the quantity of sun exposure.</p><p id="par0110" class="elsevierStylePara elsevierViewall">Another interesting point regards to the variety of assays used to measure 25OHD.<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">38</span></a> Chemiluminescence immunoassay employed in this trial show acceptable correlation with the goal standard liquid chromatography-tandem mass spectrometry.<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">39</span></a> Still, immunoassays intermethod variability exist,<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">40</span></a> thus standardization of vitamin D assays and consideration of assay-specific decision limits should be addressed.</p><p id="par0115" class="elsevierStylePara elsevierViewall">In all cases, patients with either deficiency or insufficiency of vitamin D, were supplemented with oral calcifediol according to 25OHD serum levels and independently of the season.</p><p id="par0120" class="elsevierStylePara elsevierViewall">Several clinical conclusions could be drawn from this study despite the aforementioned limitations. In first place, though the abundant sunlight throughout the year and optimal location of the study, insufficient 25OHD serum levels was commonly observed in winter and spring while autumn exhibited optimal levels in all population groups. Secondly, female elderly patients >60 yrs but also those >48 yrs were at higher risk of inadequate 25OHD serum levels during those seasons and therefore should need surveillance. Thirdly, summer exhibited high percentage of patients with 25OHD insufficient levels in all groups, which should enhance vitamin D measurements and possibly the need of supplementation during this period. In the present study, optimal levels of sunlight did not overcome the problem of inadequate 25OHD serum levels. For all these reasons, we reinforce performing 25OHD serum measurements in elderly rheumatic female population, independently of the season. Vitamin D supplementation may be recommended predominantly in winter but also in summer might be required.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflicts of interest</span><p id="par0125" class="elsevierStylePara elsevierViewall">None of the authors declares conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres1162587" "titulo" => "Abstract" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objectives" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1088593" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1162588" "titulo" => "Resumen" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Antecedentes" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivos" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Métodos" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusión" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1088592" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Patients and methods" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Study design and study population" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Measurements" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Statistical analysis" ] ] ] 6 => array:2 [ "identificador" => "sec0030" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0035" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0040" "titulo" => "Conflicts of interest" ] 9 => array:2 [ "identificador" => "xack397071" "titulo" => "Acknowledgments" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2018-03-29" "fechaAceptado" => "2018-08-23" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1088593" "palabras" => array:3 [ 0 => "Vitamin D" 1 => "Sunshine" 2 => "Women" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1088592" "palabras" => array:3 [ 0 => "Vitamina D" 1 => "luz solar" 2 => "Mujeres" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Almeria is a region in southeast Spain with optimal sunlight levels, along with low pluvial and pollution rates. If exposure to sunlight is sufficient to maintain adequate levels of vitamin D (25OHD), this population should display high serum levels.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objectives</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To describe 25OHD serum status in women from Almeria and evaluate the impact of long sunlight exposure along the seasons on 25OHD.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Cross-sectional study, performed in women consecutively recruited from an outpatient rheumatology clinic. Serum levels of 25OHD were assessed in all patients and evaluated according to age (<48 yrs, 48–53 yrs, 54–60 yrs and >60 yrs), season, and presence or absence of menopause. Clinical and laboratory variables that could affect status of vitamin D were also considered.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The sample included 319 Caucasian female patients. Mean 25OHD were 30.2<span class="elsevierStyleHsp" style=""></span>ng/ml with 195 (61.1%) exhibiting 25OHD inadequate serum levels. Season had a significant effect on 25OHD levels, with autumn being the season in which 25OHD serum levels remained well above 30<span class="elsevierStyleHsp" style=""></span>ng/ml in all age bands, and winter the season with more levels of insufficiency. Menopause did not modify 25OH serum levels. Women whose age was below 48 and over 60 had inadequate levels of 25OHD during summer.</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Optimal levels of sunlight could not overcome the problem of inadequate 25OHD serum levels, particularly in elderly and young female population. Vitamin D supplementation may be recommended predominantly in winter and summer in this population.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objectives" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Antecedentes</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Almería es una región del sureste de España con un grado óptimo de luz solar, junto con bajas tasas de contaminación y lluvia. Si la exposición a la luz solar es suficiente para mantener niveles adecuados de vitamina D (25OHD), esta población debería presentar concentraciones séricas altas.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivos</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Describir los valores séricos de 25OHD en mujeres de Almería y evaluar el efecto de la exposición prolongada a la luz solar sobre la 25OHD a lo largo de las distintas estaciones.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Métodos</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Estudio transversal en mujeres reclutadas consecutivamente en una consulta externa de reumatología. Se determinaron las concentraciones séricas de 25OHD en todas las pacientes y se valoraron en función de la edad (< 48 años, 48-53 años, 54-60 años y > 60 años), la estación y la presencia o ausencia de menopausia. También se tuvieron en cuenta las variables clínicas y analíticas que pudieran afectar al estado de la vitamina D.</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">La muestra incluyó 319 mujeres de raza blanca. El valor medio de 25OHD fue de 30,2 ng/ml, y 195 (61,1%) mostraron concentraciones séricas inadecuadas de 25OHD. La estación tenía un efecto importante en las concentraciones de 25OHD, y el otoño era la estación en la que los valores séricos de 25OHD se mantenían bastante por encima de 30 ng/ml en todas las franjas de edad, y el invierno la estación con más grado de insuficiencia. La menopausia no modificaba las concentraciones séricas de 25OH. Las mujeres menores de 48 años y mayores de 60 años tenían niveles insuficientes de 25OHD durante el verano.</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusión</span><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">La luz solar óptima no podía superar el problema de la insuficiencia de las concentraciones séricas de 25OHD, sobre todo en las poblaciones de mujeres mayores y jóvenes. Pueden recomendarse suplementos de vitamina D predominantemente en invierno y en verano en esta población.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Antecedentes" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivos" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Métodos" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusión" ] ] ] ] "multimedia" => array:5 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1221 "Ancho" => 1583 "Tamanyo" => 82261 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Patients mean 25OHD serum levels according to different seasons.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1040 "Ancho" => 2080 "Tamanyo" => 74252 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Percentage of patients with vitamin D insufficiency according to age and season.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1193 "Ancho" => 2083 "Tamanyo" => 71858 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Percentage of patients with vitamin D deficiency according to age and season.</p>" ] ] 3 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Abbreviations</span>: Ca, calcium; P, phosphorous; PTH, parathyroid hormone; AST/GOT, aspartate aminotransferase; ALT/GPT, alanine aminotransferase; GGT, gamma-glutamyl transpeptidase; Leuc, leucocytes, ng/ml, nanogram per mililitre; mg/dl, milligrams per decilitre; pg/ml, picogram per mililitre; g/dl, grams per decilitre; mm<span class="elsevierStyleSup">3</span>, cubic milimeter; Ref. values, reference values.</p><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">All values are expressed as mean (SD) unless otherwise noted.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Ref. values \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><48 yr (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>92) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">48–53 yr (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>75) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">54–60 yr (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>74) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">>60 yr (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>78) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">319 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">40.3 (6.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">50.9 (1.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">56.7 (1.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">67.2 (5.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">25OHD (ng/ml) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">>30.0–<100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">319 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28.8 (14.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28.8 (16.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">32.8 (18.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">29.9 (15.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.64 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ca (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8.6–10.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">319 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9.4 (0.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9.4 (0.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9.5 (0.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9.5 (0.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.41 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">P (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2.2–4.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">319 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.6 (0.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.7 (0.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.6 (0.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.5 (0.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.78 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Menopause (<span class="elsevierStyleItalic">n</span>, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">319 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">61.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">98.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PTH (pg/ml) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">18.4–88.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">319 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">37.4 (20.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">42.4 (19.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">42.1 (20.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">50.4 (26.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.05 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Albumin (g/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3.5–5.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">319 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.0 (0.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.1 (0.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.1 (0.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.1 (0.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.33 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">AST/GOT (U/l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><34.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">319 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18.5 (5.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21.7 (7.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22.4 (8.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20.1 (6.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.05 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">ALT/GPT (U/l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">9.0–53.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">319 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16.6 (7.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21.0 (8.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22.4 (12.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19.5 (7.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.05 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">GGT (U/l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">11.0–50.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">319 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15.6 (5.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23.1 (16.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26.4 (20.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20.9 (11.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Haematocrit (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">40.0–52.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">319 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">38.9 (2.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">40.1 (3.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">40.3 (3.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">40.8 (2.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.05 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hemoglobin (g/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13.0–17.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">319 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13.0 (1.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13.5 (1.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13.3 (16.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13.5 (0.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.36 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Leuc. (10<span class="elsevierStyleSup">3</span><span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4.0–10.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">319 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.1 (1.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.2 (1.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.4 (1.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5.9 (1.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.38 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Creatinine (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.7–1.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">319 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.8 (0.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.0 (1.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.1 (1.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.2 (1.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.41 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1984358.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Characteristics of the women included, total and by age bands.</p>" ] ] 4 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Age \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Winter</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Spring</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Autumn</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Summer</th></tr><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Group \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">n</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Mean (SD) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">n</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Mean (SD) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">n</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Mean (SD) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">n</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Mean (SD) \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><48 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25.9 (12.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27.9 (15.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">37.9 (20.1)<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">*</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28.0 (7.9) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">48–53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28.4 (12.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21.1 (10.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">39.8 (21.0)<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">*</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">29.9 (18.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">54–60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25.5 (12.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24.9 (6.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">39.2 (22.1)<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">*</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">32.2 (16.1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">>60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24.1 (13.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">31.6 (18.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">36.7 (16.1)<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">*</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26.7 (11.9) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1984357.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara" id="npar0005"><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.05.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Mean serum levels of vitamin D (ng/ml) by age bands and season.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:40 [ 0 => array:3 [ "identificador" => "bib0205" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.F. Holick" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Clin Nutr" "fecha" => "2004" "volumen" => "80" "numero" => "6 Suppl" "paginaInicial" => "1678s" "paginaFinal" => "1688s" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0210" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "McCollum Award Lecture, 1994: vitamin D – new horizons for the 21st century" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.F. Holick" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/ajcn/60.4.619" "Revista" => array:7 [ "tituloSerie" => "Am J Clin Nutr" "fecha" => "1994" "volumen" => "60" "numero" => "4" "paginaInicial" => "619" "paginaFinal" => "630" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8092101" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0215" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factors influencing vitamin D status" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "W.G. Tsiaras" 1 => "M.A. Weinstock" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Acta Dermato-Venereol" "fecha" => "2011" "volumen" => "91" "numero" => "2" "paginaInicial" => "115" "paginaFinal" => "124" "itemHostRev" => array:3 [ "pii" => "S0140673613626756" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0220" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of calcium and vitamin D in the management of osteoporosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Rizzoli" 1 => "S. Boonen" 2 => "M.L. Brandi" 3 => "N. Burlet" 4 => "P. Delmas" 5 => "J.Y. Reginster" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.bone.2007.10.005" "Revista" => array:6 [ "tituloSerie" => "Bone" "fecha" => "2008" "volumen" => "42" "paginaInicial" => "246" "paginaFinal" => "249" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18055288" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0225" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vitamin D status and comon risk factors for bone fragility as determinants of quantitative ultrasound variables in a nationally representative population samples" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Kauppi" 1 => "O. Impivaara" 2 => "J. Mäki" 3 => "M. Heliövara" 4 => "J. Marniemi" 5 => "J. Montonen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.bone.2009.03.659" "Revista" => array:6 [ "tituloSerie" => "Bone." "fecha" => "2009" "volumen" => "45" "paginaInicial" => "119" "paginaFinal" => "124" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19328875" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0230" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of vitamin D in cancer prevention" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H. Zeeb" 1 => "R. Greinert" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Medicine" "fecha" => "2010" "volumen" => "107" "numero" => "37" "paginaInicial" => "638" "paginaFinal" => "643" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0235" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessment of evidence for a protective role of vitamin D in multiple sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H.E. Hanwell" 1 => "B. Banwell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.bbadis.2010.07.017" "Revista" => array:7 [ "tituloSerie" => "Biochim Biophys Acta" "fecha" => "2011" "volumen" => "1812" "numero" => "2" "paginaInicial" => "202" "paginaFinal" => "212" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20674744" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0240" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "U-shaped relationship between vitamin D levels and long-term outcome in large cohort of survivors of acute myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Aleksova" 1 => "A.P. Beltrami" 2 => "R. Belfiore" 3 => "G. Barbati" 4 => "M. Di Nucci" 5 => "S. Scapol" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijcard.2016.08.322" "Revista" => array:6 [ "tituloSerie" => "Int J Cardiol." "fecha" => "2016" "volumen" => "223" "paginaInicial" => "962" "paginaFinal" => "966" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27589046" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0245" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.R. Martineau" 1 => "D.A. Jolliffe" 2 => "R.L. Hooper" 3 => "L. Greenberg" 4 => "J. Aloia" 5 => "P. Bergman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "BMJ." "fecha" => "2017" "volumen" => "356" "paginaInicial" => "i6583" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0250" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Why the IOM recommendations for vitamin D are deficient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.P. Heaney" 1 => "M.F. Holick" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/jbmr.328" "Revista" => array:6 [ "tituloSerie" => "J Bone Miner Res" "fecha" => "2011" "volumen" => "26" "paginaInicial" => "455" "paginaFinal" => "457" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21337617" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0255" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum 25-Hydroxyvitamin D Levels: Variability. Knowledge Gaps, and the Concept of a Desirable Range" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. El-Hajj Fuleihan" 1 => "R. Bouillon" 2 => "B. Clarke" 3 => "M. Chakhtoura" 4 => "C. Cooper" 5 => "M. McClung" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/jbmr.2536" "Revista" => array:6 [ "tituloSerie" => "J Bone Miner Res." "fecha" => "2015" "volumen" => "30" "paginaInicial" => "1119" "paginaFinal" => "1133" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25952470" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0260" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "<a id="intr0015" class="elsevierStyleInterRef" href="http://www.climatedata.eu/climate.php?loc=spxx0009%26lang=en">http://www.climatedata.eu/climate.php?loc=spxx0009⟨=en</a>. website European weather." ] ] ] 12 => array:3 [ "identificador" => "bib0265" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "<a id="intr0020" class="elsevierStyleInterRef" href="http://www.aqicn.org/">www.aqicn.org</a>. Real-time air quality index." ] ] ] 13 => array:3 [ "identificador" => "bib0270" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estimates of optimal D status" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B. Dawson-Hughes" 1 => "R.P. Heaney" 2 => "M.F. Holick" 3 => "P. Lips" 4 => "P. Meunier" 5 => "R. Vieth" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Osteoporosis Int" "fecha" => "2005" "volumen" => "16" "paginaInicial" => "713" "paginaFinal" => "716" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0275" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of ambient sunlight and photoprotection on vitamin D status" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.W. Diehl" 1 => "M.W. Chiu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1529-8019.2009.01290.x" "Revista" => array:7 [ "tituloSerie" => "Dermatol Ther" "fecha" => "2010" "volumen" => "23" "numero" => "1" "paginaInicial" => "48" "paginaFinal" => "60" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20136908" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0280" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The high prevalence of vitamin D insufficiency across Australian populations is only partly explained by season and latitude" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I.A. van der Mei" 1 => "A.L. Ponsonby" 2 => "O. Engelsen" 3 => "J.A. Pasco" 4 => "J.J. McGrath" 5 => "D.W. Eyles" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1289/ehp.9937" "Revista" => array:6 [ "tituloSerie" => "Environ Health Perspect." "fecha" => "2007" "volumen" => "115" "paginaInicial" => "1132" "paginaFinal" => "1139" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17687438" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0285" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vitamin D deficiency and seasonal variation in an adult South Florida population" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Levis" 1 => "A. Gómez" 2 => "C. Jimenez" 3 => "L. Veras" 4 => "F. Ma" 5 => "S. Lai" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Clin Endocrinol Metab." "fecha" => "2005" "volumen" => "90" "paginaInicial" => "1557" "paginaFinal" => "1562" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0290" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Associations between frailty and serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentrations in older Australian men: the Concord Health and Ageing in Men Project" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Hirani" 1 => "V. Naganathan" 2 => "R.G. Cumming" 3 => "F. Blyth" 4 => "D.G. Le Couteur" 5 => "D.J. Handelsman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "The journals of gerontology Series A. J Gerontol A Biol Sci Med Sci." "fecha" => "2013" "volumen" => "68" "paginaInicial" => "1112" "paginaFinal" => "1121" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0295" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High prevalence of vitamin D insufficiency in healthy elderly people living at home in Argentina" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Oliveri" 1 => "L. Plantalech" 2 => "A. Bagur" 3 => "A.C. Wittich" 4 => "G. Rovai" 5 => "E. Pusiol" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.ejcn.1601786" "Revista" => array:6 [ "tituloSerie" => "Eur J Clin Nutr." "fecha" => "2004" "volumen" => "58" "paginaInicial" => "337" "paginaFinal" => "342" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14749755" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0300" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum 25-hydroxyvitamin D concentrations fluctuate seasonally in young adults of diverse ancestry living in Toronto" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Gozdzik" 1 => "J.L. Barta" 2 => "A. Weir" 3 => "D.E. Cole" 4 => "R. Vieth" 5 => "S.J. Whiting" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3945/jn.110.126284" "Revista" => array:6 [ "tituloSerie" => "J Nutr." "fecha" => "2010" "volumen" => "140" "paginaInicial" => "2213" "paginaFinal" => "2220" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20980651" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0305" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vitamin D deficiency and seasonal and inter-day variation in circulating 25-hydroxyvitamin D and parathyroid hormone levels in indoor daytime workers: a longitudinal study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H. Itoh" 1 => "I. Mori" 2 => "Y. Matsumoto" 3 => "S. Maki" 4 => "Y. Ogawa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Industrial Health" "fecha" => "2011" "volumen" => "49" "numero" => "4" "paginaInicial" => "475" "paginaFinal" => "481" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21697621" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0310" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The contribution of diet and sun exposure to the nutritional status of vitamin D in elderly Spanish wom the five countries study (OPTIFORD Project)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Rodriguez Sangrador" 1 => "B. Beltran de Miguel" 2 => "L. Quintanilla Murillas" 3 => "C. Cuadrado Vives" 4 => "O. Moreiras Tuny" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Nutricion Hospitalaria" "fecha" => "2008" "volumen" => "23" "numero" => "6" "paginaInicial" => "567" "paginaFinal" => "576" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19132265" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0315" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of vitamin D deficiency during the summer and its relationship with sun exposure and skin phototype in elderly men living in the tropics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Azevedo Cabral" 1 => "C.N. Borges" 2 => "J.M. Coelho Mahia" 3 => "C.A. Martins Aires" 4 => "F. Bandeira" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Interventions Aging" "fecha" => "2013" "volumen" => "8" "paginaInicial" => "1347" "paginaFinal" => "1351" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0320" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Seasonal variations in serum vitamin D according to age and sex" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. Heidari" 1 => "M.B. Haji Mirghassemi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Caspian J Internal Med" "fecha" => "2012" "volumen" => "3" "numero" => "4" "paginaInicial" => "535" "paginaFinal" => "540" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0325" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased vitamin D supplementation recommended during summer season in the gulf region: a counterintuitive seasonal effect in vitamin D levels in adult, overweight and obese Middle Eastern residents" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N.M. Al-Daghri" 1 => "O.S. Al-Attas" 2 => "M.S. Alokail" 3 => "K.M. Alkharfy" 4 => "E. El-Kholie" 5 => "M. Yousef" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Endocrinol." "fecha" => "2012" "volumen" => "76" "paginaInicial" => "346" "paginaFinal" => "350" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0330" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Solar UV doses of adult Americans and vitamin D(3) production" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.E. Godar" 1 => "S.J. Pope" 2 => "W.B. Grant" 3 => "M.F. Holick" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermato-Endocrinol" "fecha" => "2011" "volumen" => "3" "numero" => "4" "paginaInicial" => "243" "paginaFinal" => "250" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0335" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increases in summer serum 25-hydroxyvitamin D (25OHD) concentrations in elderly subjects in Sao Paulo, Brazil vary with age, gender and ethnicity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S.S. Maeda" 1 => "I.S. Kunii" 2 => "L.F. Hayashi" 3 => "M. Lazaretti-Castro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "BMC Endocr Disorders" "fecha" => "2010" "volumen" => "10" "paginaInicial" => "12" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0340" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence and predictors of vitamin D insufficiency in women of reproductive age living in northern latitude" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. Gagnon" 1 => "J.-P. Baillargeon" 2 => "G. Deasmarais" 3 => "G.D. Fink" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur J Endocrinol/Eur Federation Endocr Soc" "fecha" => "2010" "volumen" => "163" "paginaInicial" => "819" "paginaFinal" => "824" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0345" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of vitamin D deficiency among healthy infants and toddlers" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C.M. Gordon" 1 => "H.A. Feldman" 2 => "L. Sinclair" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Pediatrics Adolescent Med" "fecha" => "2008" "volumen" => "162" "numero" => "6" "paginaInicial" => "505" "paginaFinal" => "512" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0350" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vitamin D isufficiency among free-living healthy young adults" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "V. Tangpricha" 1 => "E. Pearce" 2 => "T. Chen" 3 => "M. Hollick" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "2002" "volumen" => "112" "paginaInicial" => "659" "paginaFinal" => "662" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12034416" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0355" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Requirement for vitamin D supplementation in patients using photoprotection: variations in vitamin D levels and bone formation markers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Bogaczewicz" 1 => "E. Karczmarewicz" 2 => "P. Pludowski" 3 => "J. Zabek" 4 => "A. Wozniacka" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int J Dermatol." "fecha" => "2016" "volumen" => "55" "paginaInicial" => "176" "paginaFinal" => "183" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0360" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sunscreen use related to UV exposure, age, sex and ocupation based on personal dosimeter readings and sun-exposure behavior diaries" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Thieden" 1 => "P.A. Philipsen" 2 => "J. Sandby-Moller" 3 => "H.C. Wulf" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archderm.141.8.967" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2005" "volumen" => "141" "paginaInicial" => "967" "paginaFinal" => "973" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16103325" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0365" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of regular sunscreen use on vitamin D levels in an Australian population. Results of a randomized controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Marks" 1 => "P.A. Foley" 2 => "D. Jolley" 3 => "K.R. Knight" 4 => "J. Harrison" 5 => "S.C. Thompson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1995" "volumen" => "131" "numero" => "4" "paginaInicial" => "415" "paginaFinal" => "421" ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0370" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vitamin D inadequacy among post-menopausal women: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Gaugris" 1 => "R.P. Heaney" 2 => "S. Boonen" 3 => "H. Kurth" 4 => "J.D. Bentkover" 5 => "S.S. Sen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Quart J Med" "fecha" => "2005" "volumen" => "98" "paginaInicial" => "667" "paginaFinal" => "676" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0375" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vitamin D status among healthy postmenopausal women in South America" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G. Gonzalez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermato-Endocrinol" "fecha" => "2013" "volumen" => "5" "numero" => "1" "paginaInicial" => "117" "paginaFinal" => "120" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0380" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aging decreases the capacity of the skin to produce vitamin D3" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.K. McLaughlin" 1 => "M.F. Holick" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI112134" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "1985" "volumen" => "76" "paginaInicial" => "1536" "paginaFinal" => "1538" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2997282" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0385" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute an chronic effects of ultraviolet radiation on the skin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Walker" 1 => "J. Walk" 2 => "A. Young" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Fitzpatrick's Dermatologyin general medicine" "paginaInicial" => "1275" "paginaFinal" => "1286" "edicion" => "6th ed." "serieFecha" => "2003" ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0390" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "State-of-the-art vitamin D assays: a comparison of automated immunoassays with liquid chromatography–tandem mass spectrometry methods" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Farrell" 1 => "S. Martin" 2 => "B. McWhinney" 3 => "I. Straub" 4 => "P. Williams" 5 => "M. Herrmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1373/clinchem.2011.172155" "Revista" => array:6 [ "tituloSerie" => "Clin Chem" "fecha" => "2011" "volumen" => "58" "paginaInicial" => "531" "paginaFinal" => "542" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22230812" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0395" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of four current 25-hydroxyvitamin D assays" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "H.W.C.J. Moon" 1 => "M. Hur" 2 => "J. Song" 3 => "G.Y. Oh" 4 => "C.M. Park" 5 => "Y.M. Yun" 6 => "J.Q. Kim" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clinbiochem.2011.12.025" "Revista" => array:6 [ "tituloSerie" => "Clin Biochem" "fecha" => "2012" "volumen" => "45" "paginaInicial" => "326" "paginaFinal" => "330" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22244986" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0400" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analytical variability among methods for the measurement of 25-hydroxyvitamin D: still adding to the noise" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Holmes" 1 => "J. Garbincius" 2 => "K. McKenna" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1309/AJCPU2SKW1TFKSWY" "Revista" => array:7 [ "tituloSerie" => "Am J Clin Pathol" "fecha" => "2013" "volumen" => "140" "numero" => "4" "paginaInicial" => "550" "paginaFinal" => "560" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24045553" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack397071" "titulo" => "Acknowledgments" "texto" => "<p id="par0130" class="elsevierStylePara elsevierViewall">The authors are grateful to Mrs. Mercedes Guerra, manager of documents and archives of the Spanish Rheumatology Society (SER) Research Unit, for her assistance in the reference strategy performance and in obtaining the articles, and to Dr Loreto Carmona for helping with the figures and checking the manuscript. This study has no financial support.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/25300164/0000006600000003/v1_201903120615/S2530016418302349/v1_201903120615/en/main.assets" "Apartado" => array:4 [ "identificador" => "63844" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/25300164/0000006600000003/v1_201903120615/S2530016418302349/v1_201903120615/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2530016418302349?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 1 | 0 | 1 |
| 2024 October | 18 | 3 | 21 |
| 2024 September | 17 | 23 | 40 |
| 2024 August | 25 | 17 | 42 |
| 2024 July | 11 | 5 | 16 |
| 2024 June | 14 | 1 | 15 |
| 2024 May | 19 | 7 | 26 |
| 2024 April | 16 | 5 | 21 |
| 2024 March | 29 | 10 | 39 |
| 2024 February | 37 | 2 | 39 |
| 2024 January | 49 | 2 | 51 |
| 2023 December | 33 | 5 | 38 |
| 2023 November | 27 | 2 | 29 |
| 2023 October | 38 | 3 | 41 |
| 2023 September | 24 | 5 | 29 |
| 2023 August | 28 | 4 | 32 |
| 2023 July | 15 | 2 | 17 |
| 2023 June | 26 | 3 | 29 |
| 2023 May | 18 | 1 | 19 |
| 2023 April | 27 | 2 | 29 |
| 2023 March | 8 | 1 | 9 |
| 2023 February | 16 | 5 | 21 |
| 2023 January | 13 | 5 | 18 |
| 2022 December | 17 | 4 | 21 |
| 2022 November | 12 | 7 | 19 |
| 2022 October | 19 | 10 | 29 |
| 2022 September | 22 | 15 | 37 |
| 2022 August | 18 | 21 | 39 |
| 2022 July | 27 | 11 | 38 |
| 2022 June | 29 | 10 | 39 |
| 2022 May | 37 | 8 | 45 |
| 2022 April | 19 | 6 | 25 |
| 2022 March | 30 | 11 | 41 |
| 2022 February | 21 | 7 | 28 |
| 2022 January | 48 | 7 | 55 |
| 2021 December | 16 | 9 | 25 |
| 2021 November | 15 | 11 | 26 |
| 2021 October | 15 | 20 | 35 |
| 2021 September | 14 | 8 | 22 |
| 2021 August | 14 | 8 | 22 |
| 2021 July | 10 | 10 | 20 |
| 2021 June | 16 | 5 | 21 |
| 2021 May | 24 | 5 | 29 |
| 2021 April | 52 | 12 | 64 |
| 2021 March | 39 | 10 | 49 |
| 2021 February | 22 | 6 | 28 |
| 2021 January | 21 | 17 | 38 |
| 2020 December | 14 | 8 | 22 |
| 2020 November | 21 | 9 | 30 |
| 2020 October | 13 | 7 | 20 |
| 2020 September | 20 | 12 | 32 |
| 2020 August | 18 | 7 | 25 |
| 2020 July | 16 | 9 | 25 |
| 2020 June | 11 | 6 | 17 |
| 2020 May | 15 | 11 | 26 |
| 2020 April | 11 | 6 | 17 |
| 2020 March | 21 | 4 | 25 |
| 2020 February | 16 | 7 | 23 |
| 2020 January | 18 | 5 | 23 |
| 2019 December | 21 | 10 | 31 |
| 2019 November | 8 | 2 | 10 |
| 2019 October | 18 | 2 | 20 |
| 2019 September | 6 | 8 | 14 |
| 2019 August | 1 | 2 | 3 |
| 2019 June | 1 | 0 | 1 |
| 2019 May | 3 | 2 | 5 |
| 2019 April | 3 | 0 | 3 |
| 2019 March | 55 | 14 | 69 |
| 2019 January | 0 | 2 | 2 |
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