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Scientific letter
Carcinoid tumor on cystic ovarian teratoma
Tumor carcinoide sobre teratoma ovárico quístico
Mariana Tomé Fernández-Ladredaa,
Corresponding author
marianatomefl@yahoo.es

Corresponding author.
, Guillermo Martínez de Pinillos Gordilloa, Francisco Pichardo López de Harob, María Victoria Cózar Leóna
a Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Universitario de Valme, Área de Gestión Sanitaria Sur de Sevilla, Sevilla, Spain
b Servicio de Anatomía Patológica, Hospital Universitario de Valme, Área de Gestión Sanitaria Sur de Sevilla, Sevilla, Spain
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or bronchospasm&#44; but patient reported palpitations during them&#46; Patient differentiated these episodes from the vasomotor symptoms she had previously experienced after menopause at 52 years of age&#46; These symptoms included a generalized hot sensation not associated to sweating or facial erythema which spontaneously resolved at 55 years &#40;two years before the start of current symptoms&#41;&#46; The patient reported no associated constitutional symptoms&#46; Physical examination findings were normal&#46; Measurement of calcitonin levels in blood and metanephrines&#44; normetanephrines and 5-hydroxyindoleacetic acid in urine was requested&#46; Repeatedly high 5-hydroxyindoleacetic acid levels were found&#44; together with a mild&#44; discontinuous elevation in normetanephrines &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Calcitonin levels were normal&#46; Based on these findings&#44; chromogranin A was tested in plasma&#44; and a value of 265<span class="elsevierStyleHsp" style=""></span>ng&#47;mL &#40;No&#46;<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>134&#41; was reported&#46; Based on the suspicion of a carcinoid tumor&#44; a computed tomography &#40;CT&#41; scan and magnetic resonance imaging of the chest and abdomen were performed&#44; showing a 6<span class="elsevierStyleHsp" style=""></span>cm right adnexal lesion reported as a possible teratoma&#46; On the other hand&#44; transabdominal pelvic ultrasonography revealed a 3&#46;5<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>4<span class="elsevierStyleHsp" style=""></span>cm tumor related to the left ovary&#46; Because of heterogeneity of the results&#44; a <span class="elsevierStyleSup">111</span>In-Pentetreotide scan &#40;Octreoscan<span class="elsevierStyleSup">&#174;</span>&#41; was requested&#44; showing a tracer hyperuptake site in the left paramedial pelvic region &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; In order to relieve symptoms while planning surgery&#44; treatment was started with a somatostatin analogue &#40;lanreotide 60<span class="elsevierStyleHsp" style=""></span>mg every 28 days by the deep subcutaneous route&#41;&#44; which decreased the frequency and severity of episodes&#46; After ruling out cardiac valve involvement by echocardiography&#44; bilateral adnexectomy was performed&#46; Histological examination found a low-grade &#40;G1&#41; insular carcinoid tumor on a mature cystic teratoma in left adnexum with Ki-67 1&#8211;2&#37;&#44; low mitotic index&#44; and positive staining for chromogranin and synaptophysin in immunohistochemistry&#46; The right ovary had a mature teratoma with no associated carcinoid tumor&#46; After surgery&#44; <span class="elsevierStyleItalic">flushing</span> episodes disappeared&#44; and 5-hydroxyindoleacetic acid and normetanephrine levels normalized&#46; Octreoscan<span class="elsevierStyleSup">&#174;</span> and CT performed six months after surgery were normal&#46; Although serum chromogranin A levels markedly decreased&#44; values remained slightly elevated &#40;150&#8211;154<span class="elsevierStyleHsp" style=""></span>ng&#47;dL&#59; No<span class="elsevierStyleItalic">&#46;</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>134&#41;&#46; Since all other supplemental tests did not suggest tumor recurrence&#44; such increased levels were attributed to a drug interaction&#46; Omeprazole treatment was therefore discontinued three weeks before control laboratory tests&#44; and chromogranin A levels normalized &#40;63&#46;3 and 37<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; No&#46;&#58; 19&#46;4&#8211;98&#46;1&#41;&#46; Three years after surgery&#44; patient continues to be symptom-free&#44; and results of supplemental tests have been normal to date&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Carcinoid tumors are uncommon&#44; with an annual incidence of approximately 8 cases per 100&#44;000 population&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Only 1&#8211;2&#37; of these tumors originate in ovarian tissue&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> where they often seat&#44; as in the reported case&#44; on a cystic teratoma or dermoid tumor&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> According to some studies&#44; this confers them a better prognosis as compared to tumors not occurring on a germ cell tumor&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Although symptoms of carcinoid syndrome are highly characteristic&#44; the syndrome only occurs in a small proportion of carcinoid tumors&#46; Insular ovarian carcinoid tumor&#44; the histological subtype of our patient&#44; is most common and is the only one that is associated to carcinoid syndrome in one-third of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In the reported case&#44; menopause had to be included in differential diagnosis of flushing because of <span class="elsevierStyleItalic">patient</span> age&#46; Although hot flashes spontaneously disappear in most women a few years after the start of menopause&#44; they may persist in up to 30&#37; of women older than 60 years&#44; and in 9&#37; of those over 70 years of age&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> However&#44; hot flashes had disappeared in our patient three years after menopause&#44; and had never been associated to facial erythema as the one she subsequently experienced in the setting of carcinoid syndrome&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Chromogranin A is a protein found in neurosecretory vesicles of neuroendocrine tumor cells&#46; It is currently considered to be the best biochemical marker for follow-up of these tumors because of its high sensitivity&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> It is however less specific&#44; and there are various conditions where slight chromogranin A elevations may occur&#44; such as kidney or liver insufficiency&#46; Long-term use of proton pump inhibitors is considered the main cause of increased chromogranin A levels unrelated to a neuroendocrine tumor&#46; Decreased acidity leads to increased gastrin release and enterochromaffin cell hyperplasia&#44; with a resultant increase in chromogranin A&#46; In the case reported&#44; long-term omeprazole treatment hindered interpretation of chromogranin A during follow-up&#46; As recommended by the literature&#44; omeprazole was discontinued to obtain a reliable value of the marker&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Tom&#233; Fern&#225;ndez-Ladreda M&#44; Mart&#237;nez de Pinillos Gordillo G&#44; Pichardo L&#243;pez de Haro F&#44; C&#243;zar Le&#243;n MV&#46; Tumor carcinoide sobre teratoma ov&#225;rico qu&#237;stico&#46; Endocrinol Nutr&#46; 2014&#59;61&#58;434&#8211;436&#46;</p>"
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                          "autores" => array:6 [
                            0 => "A&#46;J&#46; Huang"
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                          ]
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                      "titulo" => "Clinical significance of blood chromogranin A measurement in neuroendocrine tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Seregni"
                            1 => "L&#46; Ferrari"
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Article information
ISSN: 21735093
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

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