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Martinez Yoldi" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Miguel J." "apellidos" => "Martinez Yoldi" "email" => array:1 [ 0 => "myoldi@clinic.ub.es" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Microbiología, Hospital Clínic i Provincial de Barcelona, Spain" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Respuesta a la carta: Persistencia a largo plazo del virus Zika después de la aparición de los síntomas" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Thank you for your considerations on our study. Regarding your concerns, we indicate in the manuscript that “Unfortunately, samples between the third and the sixth month after symptomatic illness were not available for testing. We can only suggest that somewhere between 93 and 201<span class="elsevierStyleHsp" style=""></span>dpi ZIKV RNA declined to undetectable levels” and therefore anticipate that the virus could have persisted in the semen of our patient for longer than 93 days.</p><p id="par0010" class="elsevierStylePara elsevierViewall">In respect to the possibility that the patient could have been reinfected, we have to say that it would be extremely unlike since reinfections have not been reported in the literature in contrast to viral persistence in semen. Experiments conducted in non-human primates support that ZIKV infection induces protective immunity.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "Reference" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:1 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Zika viral dynamics and shedding in rhesus and cynomolgus macaques" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.E. Osuna" 1 => "S.-Y. Lim" 2 => "C. Deleage" 3 => "B.D. Griffin" 4 => "D. Stein" 5 => "L.T. Schroeder" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nm.4206" "Revista" => array:6 [ "tituloSerie" => "Nat Med" "fecha" => "2016" "volumen" => "22" "paginaInicial" => "1448" "paginaFinal" => "1455" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27694931" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/0213005X/0000003600000001/v2_201801151148/S0213005X17302197/v2_201801151148/en/main.assets" "Apartado" => array:4 [ "identificador" => "8589" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Cartas al Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/0213005X/0000003600000001/v2_201801151148/S0213005X17302197/v2_201801151148/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X17302197?idApp=UINPBA00004N" ]
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