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Scientific letter
HIV-1 primary infection and acute hepatitis A: Beware of co-infection!
Primoinfección por VIH-1 y hepatitis A aguda: cuidado con la co-infección
Natalia Anahí Díaza,b, Juan Ambrosionib,
Corresponding author
AMBROSIONI@clinic.cat

Corresponding author.
a Infectious Diseases Service, Hospital Cesar Milstein, Buenos Aires, Argentina
b Infectious Diseases Service, Hospital Clinic-IDIPABS, Barcelona, Spain
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aspartate aminotransferase 885<span class="elsevierStyleHsp" style=""></span>IU&#47;L&#44; alanine aminotransferase 2847<span class="elsevierStyleHsp" style=""></span>IU&#47;L&#44; alkaline phosphatase 238<span class="elsevierStyleHsp" style=""></span>IU&#47;L&#44; gamma-glutamyl transferase 864<span class="elsevierStyleHsp" style=""></span>IU&#47;L and prothrombin time 67&#37;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">According to geographical origin of the patient&#44; laboratory results and clinical presentation&#44; primary hepatotropic viruses serologies &#40;HAV&#44; HBV&#44; HCV&#44; HDV&#44; HEV&#41; and viral load&#44; EBV&#44; CMV&#44; dengue&#44; chikungunya&#44; syphilis serologies and HIV 1&#47;2 4th generation EIA were requested &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; Acute hepatitis A infection was diagnosed&#44; also with serological evidence to previous exposure to dengue&#44; syphilis&#44; CMV and EBV&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Re-exploring the patient 24<span class="elsevierStyleHsp" style=""></span>h later&#44; polyadenopathies and rash were identified&#44; unnoticed the day before&#46; HIV-1 viral load was then requested&#44; being &#62;10&#44;000&#44;000<span class="elsevierStyleHsp" style=""></span>copies&#47;ml and CD4&#43; T cells count was 224&#47;mm<span class="elsevierStyleSup">3</span> &#40;17&#37;&#41;&#46; Retrospectively repeated EIA from that day resulted now positive&#44; only 24<span class="elsevierStyleHsp" style=""></span>h later than the previously negative&#46; Concomitant acute hepatitis A and severe acute primary HIV infection &#40;PHI&#41; were then the final diagnoses&#46; TDF&#47;FTC&#47;dolutegravir at usual doses were immediately started with rapid remission of symptoms and liver tests progressive improvement over the following weeks&#46; Virological&#44; immunological and biochemical markers are shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">A week later the patient&#39;s partner&#44; a 65-year-old Spanish man&#44; presented at hospital&#44; reporting their last sexual intercourse being 18 days before&#46; He had HIV negative test 2 years ago and was asymptomatic at that moment&#46; HIV RNA&#44; IgM and IgG HAV were requested&#46; HAV vaccine&#47;immune globulin was indicated depending on the results&#44; but he decided to perform laboratory tests in another hospital&#46; A week later he returned to the emergency department with fever and altered liver parameters&#46; IgG and IgM HAV were positive confirming acute hepatitis A&#44; HIV-1 viral load was undetectable&#44; excluding HIV-1 infection&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">PHI can co-exist with other sexually transmitted infections &#40;such as HAV&#41; thus health professionals should be aware and always suspect them&#46; PHI clinical symptoms may be non-specific and results of diagnostic tests rapidly modify&#44; as in the current case&#44; in 24<span class="elsevierStyleHsp" style=""></span>h&#46; Sexual intercourse during PHI is associated to high transmission risk due to uncontrolled viral replication and extremely high HIV viral load in this phase&#44; with frequent unawareness of infection&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">About 20&#37; of diagnosis in Spain and other European countries are made during acute infection &#40;detection of p24 Ag and&#47;or HIV-RNA in absence of HIV antibody&#41; or during recent infection &#40;HIV antibody detection up to 6 months after infection&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;3</span></a> Immediate ART initiation controls symptoms&#44; minimize viral reservoirs and decrease transmissibility&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Hepatitis A is an acute&#44; self-limiting disease transmitted by faecal&#8211;oral route through contaminated food or water or through person-to-person contact&#44; including sexual contact&#46; If sexual transmission of HAV is suspected&#44; particularly among men-who-have-sex-with-men &#40;MSM&#41;&#44; PHI should be excluded&#46; PHI presents clinically as a mononucleosis-like or flu-like syndrome&#44; easily missed in the context of a concomitant acute hepatitis&#46; HAV incubation period could potentially be shorter than serological evidence of HIV infection&#46; HIV RNA become positive 7&#8211;10 days after HIV exposure&#44; p24-antigen approximately 14 days and HIV antibodies at around 21 days&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Thus&#44; if concomitant or near exposure to HAV and HIV are suspected&#44; HIV RNA should be requested to exclude PHI&#46; HIV-VL is frequently extremely high in this period&#44; with increased transmission risk&#46; Complete seroconversion to HIV takes approximately 3 months until last WB band become positive &#40;usually p31 band&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Sexually transmitted outbreaks of acute hepatitis A have been reported in the last years in Europe among MSM&#44; particularly HIV-positive&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6&#8211;9</span></a> Hepatitis A infection is not more severe among HIV-infected individuals&#44; but HAV viraemia is higher and longer&#44; increasing transmission risk&#46; In high-income countries anti-HAV IgG in general population is usually low &#40;&#60;50&#37; by the age of 30 years&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> Therefore&#44; when HAV is introduced in groups at particular high-risk&#44; as MSM population&#44; outbreaks may occur&#44; stressing the importance of preventive measures&#44; particularly vaccination&#46; As for HBV and HCV&#44; HAV must also be considered as a potential co-infection in the context of PHI&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflict of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">JA has received research funding from Gilead Sc and ViiV Healthcare&#44; out of the current work&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">NAD&#58; none to declare&#46;</p></span></span>"
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ISSN: 0213005X
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos