Article information
Abstract
The echinocandins anidulafungin, caspofungin, and micafungin have a broad and similar spectrum of in vitro and in vivo activity against most Candida spp. Minimal inhibitory concentrations (MICs) for Candida spp. are usually below 1 μg/mL for most isolates. The exceptions are Candidaparapsilosis and C. guilliermondii. Species-specific clinical breakpoints (CBPs) and epidemiologic cutoff values (ECVs) have been proposed by the Clinical and Laboratory Standards Institute (CLSI) for the eight most common Candida spp. versus each echinocandin; these values are useful to detect in vitro antifungal resistance (CBPs) and to identify isolates harboring fks mutations or having reduced susceptibility (ECVs). This paper presents a review of the literature (2006–2010) regarding the in vitro activity similarities or differences among the three echinocandins against Candida spp.; different parameters or measurements of in vitro potency were evaluated. The focus of the review is the non-Candida albicans species.
Keywords:
Echinocandins
Echinocandins activity non-Candida albicans
Echinocandin ECVs for non-Candida albicans
Echinocandin CBPs or non-Candida albicans
Resumen
Las 3 candinas, anidulafungina, caspofungina y micafungina, comparten el mismo amplio espectro de acción y actividad, tanto in vitro como in vivo, sobre Candida spp. Las concentraciones mínimas inhibitorias (CMI) para la mayoría de los aislados de Candida spp. son generalmente inferiores a 1 μg/mL, excepto para C. parapsilosis y C. guilliermondii. El Clinical and Laboratory Standards Institute (CLSI) ha propuesto recientemente puntos de corte clínicos (PCC) y puntos de corte epidemiológicos (PCE) a cada candina para las 8 especies más comunes de Candida. Estos valores son útiles para detectar resistencias (PCC) e identificar aislados con mutaciones en el gen fks o con sensibilidad reducida (PCE). En este trabajo se revisa la bibliografía (2006–2010) de la actividad in vitro de las equinocandinas frente a Candida no albicans analizando diferentes parámetros de actividad in vitro para evaluar las diferencias entre ellas.
Palabras clave:
Equinocandinas
Equinocandinas y Candida no albicans
PCE equinocandinas y Candida no albicans
PCC equinocandinas y Candida no albicans
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