Características farmacocinéticas diferenciales de micafungina. Experiencia en poblaciones especiales

Grau Cerrato, Santiago; Pardos, Sonia Luque; Quirante, Olivia Ferrández

doi:10.1016/S0213-005X(11)70003-9

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Resumen

En la actualidad se dispone de 3 equinocandinas para el tratamiento de infecciones fúngicas. Micafungina ha representado la última incorporación a este grupo de antifúngicos. A pesar de presentar un mecanismo de acción similar, esta molécula tiene algunas características farmacocinéticas distintas a las del resto del grupo. Hoy en día se dispone de amplia información acerca del comportamiento farmacocinético de micafungina procedente, fundamentalmente, de los pacientes incluidos en los ensayos clínicos. Sin embargo, el conocimiento de la farmacocinética de esta equinocandina en poblaciones especiales es mucho más limitado. El objetivo de la presente revisión es analizar la información disponible sobre la farmacocinética de micafungina en pediatría, pacientes ancianos, insuficiencia renal, insuficiencia hepática y en pacientes trasplantados.

Palabras clave:

Micafungina

Farmacocinética

Pediatría

Ancianos

Insuficiencia renal

Insuficiencia hepática

Trasplante

Keywords:

Micafungin

Pharmacokinetics

Pediatrics

The elderly

Renal insufficiency

Liver failure

Transplantation

Abstract

Currently, three echinocandins are available for the treatment of fungal infections. Micafungin is the latest drug to be incorporated into this group of antifungal agents. Although the mechanism of action of micafungin is similar to that of other echinocandins, this molecule has certain pharmacokinetic characteristics that distinguish it from other drugs in this group. Nowadays, there is wide information on the pharmacokinetic behavior of micafungin, mainly from patients included in clinical trials. However, there is far less knowledge of the pharmacokinetics of this echinocandin in special populations. The aim of the current review was to analyze the available information on the pharmacokinetics of micafungin in pediatric patients, the elderly, patients with renal insufficiency or liver failure, and transplant recipient.

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