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En este artículo revisamos aspectos relacionados con la neumonía nosocomial causada por grampositivos, y especialmente de los episodios causados por Staphylococcus aureus resistenten a meticilina (SARM), por su creciente incidencia y mala evolución asociada. Evaluaremos las opciones terapéuticas disponibles, su adecuación y las opciones terapéuticas emergentes para mejorar el pronóstico de los pacientes afectados por este tipo de infecciones. Ante la escasez de alternativas eficaces en el tratamiento de la neumonía nosocomial por SARM, discutimos la disyuntiva de considerar linezolid como la mejor opción disponible.
Palabras clave:
SARM
Neumonía nosocomial
Grampositivos
Antimicrobianos
This article reviews aspects related to nosocomial pneumonia due to Gram-positive microorganisms and especially episodes due to MRSA, because of their growing incidence and poor prognosis. The available therapeutic options, their suitability, and the emergent therapeutic options that aim to improve prognosis in patients with this kind of infection are evaluated. Given the lack of effective alternatives to treat nosocomial pneumonia due to MRSA, the possibility of using linezolid as the best available strategy to date is discussed.
Key words:
MRSA
Nosocomial pneumonia
Gram-positive
Antimicrobial agents
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Financiado por AGAUR (05/SGR/920), Fondo de Investigaciones Sanitarias (PI04/1500), CIBER Enfermedades Respiratorias (CIBERes 06/06/0036) y MARATOTV3.
Jordi Rello ha recibido becas de investigación de Novartis, Pfizer, Lilly, es consultor de Basilea, Merck & Co., Pfizer, Wyeth Aerst Pharmaceuticals, J & J, Arpida, Intercell, Novartis, Sanofi y speaker de Astra-Zeneca, Pfizer, Merck & Co. y Wyeth.
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