Article information
Abstract
Before the advent of the influenza A(H1N1)pdm virus in 2009, the information available about the clinical manifestations and prognosis of influenza in immunosuppressed patients was scarce. With the 2009 pandemic, knowledge of the behavior, severity and importance of antiviral therapy for influenza A infection in immunocompromised hosts has increased considerably. The aim of the present manuscript is to review the main challenges of influenza in the most representative immunosuppressed populations such as solid organ transplant recipients, hematopoietic stem cell transplant recipients, patients with solid and hematological cancer and human immunodeficiency virus infected patients.
Keywords:
Immunosuppressed patients
Influenza
Outcome
Transplant
Cancer patients
Human immunodeficiency virus
Resumen
Antes de 2009, momento en que se produjo la aparición de la gripe A(H1N1)pdm, no existía mucha información sobre las manifestaciones clínicas y el pronóstico de la gripe en los pacientes inmunodeprimidos. Sin embargo, desde la pandemia de 2009, el conocimiento de la conducta, la gravedad y la importancia del tratamiento antiviral para la infección por gripe A en huéspedes inmunodeprimidos han aumentado considerablemente. En este artículo se describen cuáles son los principales desafíos de la gripe en las poblaciones inmunodeprimidas más representativas como son los pacientes infectados por el virus de la inmunodeficiencia humana, pacientes con cáncer sólido o hematológico y los receptores de trasplante de órganos o de células madre hematopoyéticas.
Palabras clave:
Pacientes inmunodeprimidos
Gripe
Pronóstico
Trasplante
Pacientes con cáncer
Virus de la inmunodeficiencia humana
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