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Inicio Enfermedades Infecciosas y Microbiología Clínica Update on bacterial pathogens: virulence and resistance
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Vol. 26. Issue S3.
Pages 3-21 (April 2008)
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Vol. 26. Issue S3.
Pages 3-21 (April 2008)
Monographic: “update on infectious diseases”
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Update on bacterial pathogens: virulence and resistance
Actualización en patógenos bacterianos: virulencia y resistencia
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Emilia Cercenadoa,
Corresponding author
ecercenado@terra.es

Correspondence: Dr. E. Cercenado. Servicio de Microbiología. Hospital General Universitario Gregorio Marañón. Dr. Esquerdo, 46. 28007 Madrid. Spain. Telf.: 91-5868459. Fax: 91-5044906.
, Javier Garaub, Benito Almirantec, José Ramón Azanzad, Rafael Cantóne, Ramón Cisternaf, José María Eirosg, Carmen Fariñash, Jesús Fortúni, Francisco Gudiolj, José Mensak, Jerónimo Pachónl, Álvaro Pascualm, José Luis Pérezn, Alejandro Rodríguezo, Miguel Sánchezp, Jordi Vilaq
a Servicio de Microbiología. Hospital General Universitario Gregorio Marañón. Madrid. Spain
b Servicio de Enfermedades Infecciosas. Hospital Mutua de Terrassa. Barcelona. Spain
c Servicio de Enfermedades Infecciosas. Hospitall Vall d’Hebron. Barcelona. Spain
d Servicio de Farmacología Clínica. Hospital de Pamplona. Spain
e Servicio de Microbiología. Hospital Ramón y Cajal. Madrid. Spain
f Servicio de Microbiología. Hospital de Basurto. Bilbao. Spain
g Servicio de Microbiología. Hospital Clínico Universitario. Valladolid. Spain
h Servicio de Enfermedades Infecciosas. Hospital Marqués de Valdecilla. Santander. Spain
i Servicio de Enfermedades Infecciosas. Hospital Ramón y Cajal. Madrid. Spain
j Servicio de Enfermedades Infecciosas. Hospital de Bellvitge. Barcelona. Spain
k Servicio de Medicina Interna. Hospital Clínic. Barcelona. Spain
l Servicio de Enfermedades Infecciosas. Hospital Virgen del Rocío. Sevilla. Spain
m Servicio de Microbiología. Hospital Virgen Macarena. Sevilla. Spain
n Servicio de Microbiología. Hospital Son Dureta. Palma de Mallorca. Spain
o Servicio de Medicina Intensiva. Hospital Joan XXIII. Tarragona. Spain
p Servicio de Medicina Intensiva. Hospital Príncipe de Asturias. Alcalá de Henares. Madrid. Spain
q Servicio de Microbiología. Hospital Clínic. Barcelona. Spain
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The present article is an update of the literature on bacterial pathogens. Recognizing the interest and scientific and public health importance of infections produced by bacterial pathogens with new virulence mechanisms and/or new mechanisms of resistance to antimicrobial agents, a multidisciplinary group of Spanish physicians and microbiologists organized a joint session and revised the most important papers produced in the field during 2006. Each article was analyzed and discussed by one of the members of the panel. This paper focus on a variety of diseases that pose major clinical and public health challenges today; and include infections produced by community-acquired methicillin-resistant Staphylococcus aureus and S. aureus small colony variants, infections produced by multiply resistant coagulase-negative staphylococci, pneumococcal infections, human listeriosis, meningococcal disease, Haemophilus influenzae, pertussis, Escherichia coli, ESBL-producing organisms, and infections due to non-fermenters. After a review of the state of the art, papers selected in this field are discussed.

Key words:
Bacterial infections
Resistance to antimicrobials
Community-acquired-MRSA
S. aureus small colony variants
Resistance to linezolid
Pneumococcal vaccines
Listeria monocytogenes
Neisseria meningitides
Haemophilus influenzae
Bordetella pertussis
Escherichia coli
Klebsiella pneumoniae
ESBL producers
Pseudomonas aeruginosa
Acinetobacter baumannii

El presente artículo recoge una actualización bibliográfica de patógenos bacterianos. Dado el interés científico y la importancia que tienen para la salud pública las infecciones producidas por patógenos bacterianos con nuevos mecanismos de virulencia y/o nuevos mecanismos de resistencia a los antimicrobianos, un grupo multidisciplinario de microbiólogos y clínicos españoles, con experiencia en enfermedades infecciosas, organizó una reunión en la que se revisaron los artículos más importantes en este campo, publicados en 2006.

El contenido de cada uno de los artículos seleccionados fue expuesto y discutido por uno de los miembros del grupo. Este artículo revisa algunas de las enfermedades infecciosas bacterianas que suponen hoy en día algunos de los principales retos para la salud pública e incluye las infecciones producidas por Staphylococcus aureus resistente a meticilina de adquisición comunitaria, las producidas por variantes de colonia pequeña de S. aureus, las relacionadas con estafilococos coagulasa negativa multirresistentes, la infección neumocócica, la listeriosis humana, la infección meningocócica, la tos ferina, las infecciones por Haemophilus influenzae, la diseminación de las bacterias productoras de BLEE, y las infecciones por bacilos gramnegativos no fermentadores. Tras la revisión de la situación actual, se discuten y comentan diferentes artículos relacionados con estos aspectos.

Palabras clave:
Infecciones bacterianas
Resistencia a antibióticos
SARM de adquisición comunitaria
Variantes de colonia pequeña de Staphylococcus aureus
Resistencia a linezolid
Vacunas neumocócicas
Listeria monocytogenes
Neisseria meningitides
Haemophilus influenzae
Bordetella pertussis
Escherichia coli
Klebsiella pneumoniae
Productores de BLEE
Pseudomonas aeruginosa
Acinetobacter baumannii
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