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(B) Histological section of the skin biopsy stained with Periodic Acid-Schiff showing hyphae and angioinvasion of the nearby vasculature. (C) Sporangiophores and rhizoids characteristic of <span class="elsevierStyleItalic">Saksenaea</span> spp. (stained with lactophenol blue).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ander Uribarri García, Aitziber Aguinaga Pérez, Miguel Fernández Huerta, Carmen Ezpeleta Baquedano" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Ander" "apellidos" => "Uribarri García" ] 1 => array:2 [ "nombre" => "Aitziber" "apellidos" => "Aguinaga Pérez" ] 2 => array:2 [ "nombre" => "Miguel" "apellidos" => "Fernández Huerta" ] 3 => array:2 [ "nombre" => "Carmen" "apellidos" => "Ezpeleta Baquedano" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0213005X24001952" "doi" => "10.1016/j.eimc.2024.01.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X24001952?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529993X24001205?idApp=UINPBA00004N" "url" => "/2529993X/0000004200000009/v1_202411050502/S2529993X24001205/v1_202411050502/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2529993X24002260" "issn" => "2529993X" "doi" => "10.1016/j.eimce.2024.09.008" "estado" => "S300" "fechaPublicacion" => "2024-11-01" "aid" => "2875" "copyright" => "The Author(s)" "documento" => "article" "crossmark" => 1 "subdocumento" => "rev" "cita" => "Enferm Infecc Microbiol Clin. 2024;42:516-26" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review article</span>" "titulo" => "The current status of arboviruses with major epidemiological significance in Europe" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "516" "paginaFinal" => "526" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Perspectiva actual de los arbovirus de mayor significación epidemiológica en Europa" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1418 "Ancho" => 2475 "Tamanyo" => 243684 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Evolution of number of cases and deaths caused by West Nile virus infection in the European Union (EU).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Fernando de la Calle-Prieto, Marta Arsuaga, Graciela Rodríguez-Sevilla, Nancy Sandoval Paiz, Marta Díaz-Menéndez" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Fernando" "apellidos" => "de la Calle-Prieto" ] 1 => array:2 [ "nombre" => "Marta" "apellidos" => "Arsuaga" ] 2 => array:2 [ "nombre" => "Graciela" "apellidos" => "Rodríguez-Sevilla" ] 3 => array:2 [ "nombre" => "Nancy Sandoval" "apellidos" => "Paiz" ] 4 => array:2 [ "nombre" => "Marta" "apellidos" => "Díaz-Menéndez" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529993X24002260?idApp=UINPBA00004N" "url" => "/2529993X/0000004200000009/v1_202411050502/S2529993X24002260/v1_202411050502/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Diagnosis at first sight</span>" "titulo" => "Are these lesions contagious?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "527" "paginaFinal" => "528" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Maria Ana Quadros Flores, Yuliya Volovetska, Tiago Marques, José Melo Cristino" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Maria Ana" "apellidos" => "Quadros Flores" "email" => array:1 [ 0 => "m.anaqfs@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Yuliya" "apellidos" => "Volovetska" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Tiago" "apellidos" => "Marques" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "José" "apellidos" => "Melo Cristino" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Infectious Diseases Department, Centro Hospitalar Universitário de Lisboa Norte, EPE/Hospital de Santa Maria, Lisboa, Portugal" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Clinical Pathology, Centro Hospitalar Universitário de Lisboa Norte, EPE/Hospital de Santa Maria, Lisboa, Portugal" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Faculty of Medicine, University of Lisbon, Lisboa, Portugal" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "¿Estas lesiones son contagiosas?" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 957 "Ancho" => 755 "Tamanyo" => 124934 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Lumps on the left earlobe.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We report a case of a 44-year-old man, with no notable medical history, originally from Nigeria, living in Portugal for about 1 month, who went to the Emergency Department complaining of hypoesthesia and itching in his right leg for about 9 months. He reported the appearance of multiple nodules approximately 3 months ago, initially on the lower limbs (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>), with subsequent spread to the trunk, upper limbs, face, and auricular pavilion (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). On physical examination, the patient presented with multiple nodules, some with a central crust, on the face, left auricular pavilion, upper limbs, and right lower limb. Salmon-colored conjunctivitis was also noted. Laboratory tests were notable for normocytic normochromic anemia and leukopenia.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">He was referred to outpatient Dermatology and Infectious Diseases consultations and underwent skin biopsies of the lesions for direct examination to search for mycobacteria. Direct examination (<span class="elsevierStyleItalic">Ziehl-Neelsen</span> staining) revealed the presence of multiple clusters of intracellular acid-fast bacilli (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">He initiated a triple therapy with dapsone, rifampicin, and clofazimine, with no significant adverse effects. Upon clinical reevaluation after 1 month of treatment, an improvement in skin lesions was observed, with no rhinitis or conjunctivitis.</p><p id="par0070" class="elsevierStylePara elsevierViewall">We did not perform any exams to evaluate whether the patient had neurological involvement because sensitivity improved with antibiotic therapy. The patient is currently (December 2023) on the ninth month of antibiotherapy, and the plan is to complete twelve months. We will perform skin slits at the end of the course of therapy.</p><p id="par0040" class="elsevierStylePara elsevierViewall">The described case illustrates the presentation of lepromatous leprosy with more than six disseminated lepromas, rhinosinusitis, and salmon-colored conjunctivitis. It is important to do an early diagnosis, as prompt treatment is effective and can prevent long-term neurological damage.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Leprosy, or Hansen's disease, is an infectious disease caused by <span class="elsevierStyleItalic">Mycobacterium leprae</span> and <span class="elsevierStyleItalic">Mycobacterium lepromatosis</span>, involving the skin and peripheral nerves. It predominantly occurs in developing countries, with higher prevalence in India, Brazil, Indonesia, Bangladesh, and Nigeria. With the increase of international traveling, it is a possible diagnosis anywhere in the world. Contrary to popular belief, leprosy is not highly contagious, and the treatment is quite effective.</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0055" class="elsevierStylePara elsevierViewall">This article received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.</p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0010" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interest" ] 2 => array:2 [ "identificador" => "xack786915" "titulo" => "Acknowledgment" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 960 "Ancho" => 755 "Tamanyo" => 101054 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hypopigmented lesion on the lower limb.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 957 "Ancho" => 755 "Tamanyo" => 124934 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Lumps on the left earlobe.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 806 "Ancho" => 755 "Tamanyo" => 53596 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Multiple clusters of acid-fast bacilli within cells (Ziehl-Neelsen).</p>" ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack786915" "titulo" => "Acknowledgment" "texto" => "<p id="par0065" class="elsevierStylePara elsevierViewall">We are grateful to the patient for providing permission to publish the case.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/2529993X/0000004200000009/v1_202411050502/S2529993X24001138/v1_202411050502/en/main.assets" "Apartado" => array:4 [ "identificador" => "63560" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Diagnosis at first sight" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/2529993X/0000004200000009/v1_202411050502/S2529993X24001138/v1_202411050502/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529993X24001138?idApp=UINPBA00004N" ]
