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Editorial
The challenge of infectious diseases in the emergency department: Presentation of 3 cases
El reto de la enfermedad infecciosa en los servicios de urgencias: a propósito de 3 estudios
Òscar Miró
Área de Urgencias, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Infectious diseases are one of the most prevalent conditions treated in hospital emergency departments &#40;EDs&#41;&#46; However&#44; they are also one of the most difficult to diagnose&#44; as shown by the fact that more diagnostic errors occur with infectious diseases than with other conditions&#44; and that 1 in 6 patients with fever discharged from EDs will be readmitted within 7 days of discharge&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1&#44;2</span></a> Three research articles that underline the persistence of these diagnostic&#44; treatment and prognostic challenges faced by ED physicians are presented in this issue of <span class="elsevierStyleItalic">Enfermedades Infecciosas y Microbiolog&#237;a Cl&#237;nica</span>&#46; While each article deals with a completely different condition&#44; they are all studies conducted in hospital EDs by emergency department staff&#44; hereinafter referred to as <span class="elsevierStyleItalic">emergency physicians</span>&#46; This means that the questions that they pose and the solutions they recommend all fall under this particular remit&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In terms of diagnostic challenges&#44; Morales-Casado et al&#46; investigate the capacity of different biomarkers to establish a differential diagnosis between acute bacterial and viral meningitis&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">3</span></a> This is without a doubt one of the key unresolved problems of the 21st century&#44; at least in terms of establishing a differential diagnosis during the patient&#39;s first consultation&#46; In a retrospective series of 154 patients&#44; the authors conclude that the biomarkers independently associated with acute bacterial meningitis diagnosis&#44; in order of level of association&#44; are&#58; cerebrospinal fluid &#40;CSF&#41; lactate &#8805;33<span class="elsevierStyleHsp" style=""></span>mg&#47;dl &#40;odds ratio &#91;OR&#93;&#58; 51&#41;&#44; serum procalcitonin &#8805;0&#46;8<span class="elsevierStyleHsp" style=""></span>ng&#47;ml &#40;OR&#58; 46&#41;&#44; glycorrhachia &#60;60&#37; blood glucose &#40;OR&#58; 21&#41; and proportion of CSF polymorphonucleocytes &#62;50&#37; &#40;OR&#58; 20&#41;&#46; Three aspects really stand out from the study&#39;s results&#46; Firstly&#44; according to the results of this and other studies&#44;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">4&#44;5</span></a> the classic glycorrhachia and leukocyte differential count parameters seem to have been superseded by CSF lactate and plasma procalcitonin&#46; As other authors have also suggested&#44;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">6</span></a> we are probably on the verge of a new paradigm in the differential diagnosis of meningitis in the ED&#46; Before this can happen&#44; however&#44; certain deficiencies in hospital EDs will have to be addressed&#46; While lactic acid availability is practically universal across EDs&#44; the same cannot be said for procalcitonin&#46; For example&#44; only 20 of the 79 hospital EDs in Catalonia &#40;25&#37;&#41; had the facility to measure procalcitonin 24<span class="elsevierStyleHsp" style=""></span>h a day in 2012&#44; and in 58&#37; this test was not available at any time of day&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">7</span></a> Secondly&#44; and following on from the point above&#44; procalcitonin may be the first accurate non-CSF biomarker that can support the decision-making process&#46; In fact&#44; a concentration &#8805;0&#46;8<span class="elsevierStyleHsp" style=""></span>ng&#47;ml yields a positive predictive value of 98&#46;5&#37;&#44; according to the results presented in the study&#46; This means that antibiotic treatment should be initiated immediately if a patient presents with clinical symptoms of acute meningitis plus a procalcitonin value &#8805;0&#46;8<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#44; even if symptoms are suggestive of viral meningitis&#46; Finally&#44; the results generated by the study by Morales-Casado et al&#46; do not solve the problem posed by partially-treated meningitis&#59; that is&#44; those patients in whom a fall in CSF glycorrhachia and an increase in CSF polymorphonucleocytes cannot be determined as a result of prior antibiotic use&#46; As such&#44; when the authors analyzed patients with possible partially-treated meningitis&#44; the expected increases in plasma procalcitonin and CSF lactate observed in confirmed cases were not seen in this patient population&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The study by Gonz&#225;lez del Castillo et al&#46;&#44; on the other hand&#44; dealt with the complex topic of appropriate antibiotic prescribing in hospital EDs&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">8</span></a> As in many other areas of clinical practice&#44; this decision must initially be taken empirically&#46; The authors report that antibiotics are inappropriately prescribed in approximately 1 out of every 10 patients&#44; and that inappropriate prescribing is correlated to an increased length of hospital stay&#46; It is important to point out that empirical antibiotic prescribing in EDs can improve&#46; This takes on particular relevance if we assume the authors&#8217; premise that such an improvement would lead to more optimal outcomes&#46; In this regard&#44; Moncl&#250;s Cols et al&#46; studied antibiotics prescribed by EDs to both admitted and discharged patients and found that&#44; while the antibiotic administered in the ED was adequately adjusted to renal function in 95&#37; of patients and dosing intervals were correct in 94&#37; of cases&#44; 37&#37; of patients with positive cultures had to switch antibiotic in accordance with the microbiological isolates&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">9</span></a> As such&#44; the implementation of clinical guidelines&#44; establishment of consensus statements and founding of infection control committees should be the best tools for ensuring increasingly appropriate antibiotic prescribing in hospital EDs&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">10&#44;11</span></a> The advantage of the series by Gonz&#225;lez del Castillo et al&#46; is that it is quite a representative sample&#44; the patients having been consecutively recruited when the authors were on duty&#46; However&#44; this is somewhat offset by the fact that the study was conducted in a single hospital ED and only included hospitalised patients&#46; It should be noted that it is vitally important for <span class="elsevierStyleItalic">emergency physicians</span> to identify those patients discharged who are at the greatest risk of bacteraemia&#44; as the possibility of correcting antibiotic therapy is smaller and would probably happen later&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a> Until recently&#44; blood cultures have been taken systematically in patients diagnosed in the ED with major infections&#44; such as pneumonia&#44; urinary tract infection&#44; cellulitis and gastroenteritis&#46; However&#44; numerous studies have questioned this practice in recent years and the debate continues to rage&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Finally&#44; Juli&#225;n-Jim&#233;nez et al&#46; tackle the crucial subject of establishing a prognosis in patients who attend hospital EDs due to infection&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">13</span></a> As important as choosing the appropriate treatment&#44; the <span class="elsevierStyleItalic">emergency physician</span> must decide whether to admit or discharge the patient&#46; Knowing the short-term prognosis of the patient plays a crucial role in this decision&#46; This is never an easy decision&#44; and is even more complicated in elderly patients in whom identifying warning signs can often be more difficult&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">14</span></a> In this scenario&#44; the study by Juli&#225;n-Jim&#233;nez et al&#46; has special merit&#46; The authors propose a scale&#44; known as LIBPAS&#44; comprising serum lactate concentration&#44; the Barthel index and systolic blood pressure&#44; which offers extremely high diagnostic performance to predict 30-day mortality&#44; with an area under the ROC curve of 0&#46;971&#46; On this basis&#44; the authors propose certain cut-off points to separate groups with vastly differing mortality&#58; from 4&#46;5&#37; in the low-risk group &#40;0 points on the LIBPAS scale&#41; to 95&#46;5&#37; in the high-risk group &#40;5 points on the LIBPAS scale&#41;&#46; These spectacular results require deeper analysis&#44; both in terms of internal validation &#40;not presented by the authors&#41; as well as external validation in general clinical practice in hospital EDs&#46; The LIBPAS scale was conceived from an observational study in 8 Spanish EDs for patients aged 75 years and above&#46; One aspect that the study fails to clarify is the percentage of patients for whom treatment was withheld or limited&#44; as it would appear that this option was chosen for a significant number of patients with a low Barthel index and low systolic blood pressure&#46; If this were the case&#44; the high mortality associated with a high LIBPAS score would be a reflection of the medical practice &#40;palliative&#41; rather than the severity of the condition&#44; at least exclusively&#46; Equally&#44; the recommendation to admit patients with a high LIBPAS score to the intensive care unit&#44; as proposed by the authors&#44; could have limited scope in the specific target population&#46; In any event&#44; the study by Juli&#225;n-Jim&#233;nez et al&#46; underlines the importance of agreeing an approach to treating infectious disease in hospital EDs&#46; In this light&#44; the recent publication of the PIPA project &#40;infection in elderly patients project&#41; could represent the first step on this journey&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">15</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">I could not let this unique occasion pass&#44; upon which 3 ED-based infection studies conducted by <span class="elsevierStyleItalic">emergency physicians</span> have been published in <span class="elsevierStyleItalic">Enfermedades Infecciosas y Microbiolog&#237;a Cl&#237;nica</span>&#44; without acknowledging the combined research efforts of both <span class="elsevierStyleItalic">infectologists</span> and <span class="elsevierStyleItalic">emergency physicians</span>&#59; 2 medical specialties with no tradition thus far of contributing to medical research in Spain&#46; Hospital emergency departments are a unique setting that play host to the first hours of acute conditions&#44; including infections and&#44; in exceptional cases&#44; sepsis&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">14&#44;16&#44;17</span></a> As such&#44; there are certain aspects that can only be approached in this setting and the collaboration of both specialties is vital&#46; This has been going on for some time in the field of cardiovascular disease&#44; with promising results&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">18&#8211;20</span></a> Multidisciplinary research is undoubtedly the key to advancing our knowledge of infectious diseases in the future&#44; and this collaboration between the different specialties can only benefit the patient&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest with regards to this article&#46;</p></span></span>"
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Article information
ISSN: 2529993X
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos