Letter to the Editor
About “Executive summary of the GeSIDA consensus document on control and monitoring of HIV-infected patients”
Acerca de “Resumen ejecutivo del Documento de Consenso de GeSIDA sobre el control y la monitorización de la infección por el VIH”
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Although we recognize the difficulties of a comprehensive evaluation of these patients, we miss in this consensus a specific mention of chronic obstructive pulmonary disease (COPD) in PLWH.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Different reviews have described COPD in PLWH, showing an increasing prevalence of COPD in PLWH compared to general population as it happens with other comorbidities.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Smoking is the major predictor of COPD appearance <a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> and smoking habit is increased in PLWH.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Nevertheless, the relation between COPD and HIV is not limited to tobacco exposure, as exposure to HIV is a predisposing factor for COPD independently from tobacco consumption.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> The prevalence of COPD in PLWH can be higher than 10%,<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> making it a medical condition that implies a considerate burden in quality of life and mortality.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> However, COPD in PLWH seems to be largely undiagnosed.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Even though the underlying pathogenesis of COPD in PLWH is not entirely clear, it seems that immune variations such as a low CD4 cell count, a low CD4 nadir, or low CD4/CD8 ratio, that contribute to accelerated aging and are associated with the risk of cardiovascular, renal or neurological comorbidities, are also involved in COPD development.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> Decline of respiratory function seems to be higher in PLWH than in HIV negative individuals.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> Both lower CD4 cell counts and higher HIV viral load were associated with an accelerated decline of respiratory function (FEV1 and FVC).<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,8</span></a> Additionally, PLHW suffering from COPD, compared to those without such comorbidity, present a higher number of hospitalizations for a respiratory-related condition, a higher incidence of community-acquired bacterial pneumonia,<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> and higher mortality rates.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">On the light of the evidence described, we believe that COPD prevention, diagnosis and treatment in PLWH deserves a more relevant position. We suggest to follow the European AIDS Clinical Society Guidelines regarding chronic lung disease screening in PLWH.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> These guidelines identify risk patients to be screened as those having three conditions: (1) being 40 years or older, (2) an accumulated smoking history of 10 pack years, and (3) to present in a regular basis respiratory symptoms such as shortness of breath, productive or non-productive cough and wheezing. Patients with these three conditions should be assessed with spirometry with bronchodilation study and CO diffusion capacity test, in order to acknowledge the presence and reversibility of airflow limitations. Furthermore, inquiry regarding tobacco consumption is fundamental for the implementation of risk reduction policies and information about the health benefits of smoking cessation should be provided and encouraged.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1,10</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion, we believe that, in addition to other comorbidities, COPD is an important condition for PLWH with relevant implications on life expectancy and quality of life. Unfortunately, it is largely underdiagnosed in PLWH, which might reflect a lack of awareness of its relevance in this population. We believe that the importance of COPD diagnosis and prevention in PLWH should be underlined and that future consensus should include COPD evaluation in their recommendations, as physicians’ awareness on its prevention and diagnosis would improve the care we provide to PLWH.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Executive summary of the GeSIDA consensus document on control and monitoring of HIV-infected patients" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "AIDS Study Group (GeSIDA) of the Spanish Society of Infectious Diseases and Clinical Microbiology" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eimc.2018.03.011" "Revista" => array:6 [ "tituloSerie" => "Enferm. Infecc. Microbiol. Clin." "fecha" => "2019" "volumen" => "37" "paginaInicial" => "467" "paginaFinal" => "475" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29793873" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0060" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HIV-associated obstructive lung diseases: insights and implications for the clinician" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.B. Drummond" 1 => "G.D. Kirk" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet Respir" "fecha" => "2014" "volumen" => "2" "paginaInicial" => "583" "paginaFinal" => "592" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0065" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic lung disease in HIV patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Neri" 1 => "J. Leung" 2 => "G. Besutti" 3 => "A. Santoro" 4 => "L.M. Fabbri" 5 => "G. Guaraldi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.24875/AIDSRev.18000002" "Revista" => array:6 [ "tituloSerie" => "AIDS Rev." "fecha" => "2018" "volumen" => "20" "paginaInicial" => "150" "paginaFinal" => "157" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30264824" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0070" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of chronic obstructive pulmonary disease in the global population with HIV: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.J. Bigna" 1 => "A.M. Kenne" 2 => "S.L. Asangbeh" 3 => "A.T. Sibetcheu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet Glob Heal" "fecha" => "2018" "volumen" => "6" "paginaInicial" => "e193" "paginaFinal" => "e202" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0075" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Markers of chronic obstructive pulmonary disease are associated with mortality in people living with HIV" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Triplette" 1 => "A. Justice" 2 => "E.F. Attia" 3 => "J. Tate" 4 => "S.T. Brown" 5 => "M.B. Goetz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/QAD.0000000000001701" "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2018" "volumen" => "32" "paginaInicial" => "487" "paginaFinal" => "493" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29135579" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0080" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High prevalence of undiagnosed COPD in a cohort of HIV-infected smokers" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Makinson" 1 => "M. Hayot" 2 => "S. Eymard-Duvernay" 3 => "M. Quesnoy" 4 => "F. Raffi" 5 => "L. Thirard" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00154914" "Revista" => array:6 [ "tituloSerie" => "Eur. Respir. J." "fecha" => "2015" "volumen" => "45" "paginaInicial" => "828" "paginaFinal" => "831" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25323226" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0085" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "COPD in HIV-infected patients: CD4 cell count highly correlated" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Puglièse" 1 => "A. Naqvi" 2 => "E. Demonchy" 3 => "E. Cua" 4 => "J. Durant" 5 => "C.-H. Marquette" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0169359" "Revista" => array:5 [ "tituloSerie" => "PLOS ONE" "fecha" => "2017" "volumen" => "12" "paginaInicial" => "e0169359" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28056048" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0090" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of HIV infection on longitudinal lung function decline among injection drug users: a prospective cohort" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.B. Drummond" 1 => "C.A. Merlo" 2 => "J. Astemborski" 3 => "M. Marshall" 4 => "A. Kisalu" 5 => "J.F. Mcdyer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/QAD.0b013e32835e395d" "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2013" "volumen" => "27" "paginaInicial" => "1303" "paginaFinal" => "1311" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23299176" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0095" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Decreased lung function and all-cause mortality in HIV-infected individuals" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.R. Gingo" 1 => "M. Nouraie" 2 => "C.J. Kessinger" 3 => "R.M. Greenblatt" 4 => "L. Huang" 5 => "E.C. Kleerup" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1513/AnnalsATS.201606-492OC" "Revista" => array:6 [ "tituloSerie" => "Ann Am Thorac Soc" "fecha" => "2018" "volumen" => "15" "paginaInicial" => "192" "paginaFinal" => "199" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29313714" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0100" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "European AIDS Clinical Society. 2019 European AIDS Clinical Society (EACS) Guidelines for the treatment of adult HIV-positive persons version 10.0 November 2019. Available from: <a target="_blank" href="https://www.eacsociety.org/files/2019_guidelines-10.0_final.pdf">https://www.eacsociety.org/files/2019_guidelines-10.0_final.pdf</a>." ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/2529993X/0000003800000006/v1_202005310634/S2529993X2030099X/v1_202005310634/en/main.assets" "Apartado" => array:4 [ "identificador" => "66012" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/2529993X/0000003800000006/v1_202005310634/S2529993X2030099X/v1_202005310634/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529993X2030099X?idApp=UINPBA00004N" ]
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