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Diagnosis at first sight
Unusual finding in Gram staining of blood cultures in a patient with prolonged febrile neutropenia and acute myeloid leukaemia
Hallazgo inusual en la tinción Gram de hemocultivos en una paciente con neutropenia febril prolongada y leucemia mieloide aguda
Julián Andrés Hoyos-Pulgarína,b, Deving Arias-Ramosb,c,
Corresponding author
deving.arias@gmail.com

Corresponding author.
, Jaime Alberto Gonzalez-Diazd, Natalia Maria Ramireze
a Medicina Interna y Enfermedades Infecciosas, Oncólogos de Occidente, Pereira, Colombia
b Grupo de Investigación en Medicina Interna, Universidad Tecnológica de Pereira, Pereira, Colombia
c Medicina Interna, Universidad Tecnológica de Pereira, Pereira, Colombia
d Medicina Interna, Hematología y Oncología, Oncólogos del Occidente, Armenia, Colombia
e Medicina general, Oncólogos del Occidente, Armenia, Colombia
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1</a>C&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Clinical course</span><p id="par0010" class="elsevierStylePara elsevierViewall">Our centre lacks techniques for galactomannan and 1&#44;3-&#174;<span class="elsevierStyleSmallCaps">d</span>-glucan detection&#59; therefore&#44; they were not used&#46; Skin biopsies were not taken either&#46; Round&#44; white&#44; flat and hairy colonies grew in a blood agar medium &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#44; and a stain with KOH showed hyaline septate hyphae with branching at an acute angle &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41;&#46; A differential diagnosis was established between <span class="elsevierStyleItalic">Aspergillus</span> spp&#46;&#44; <span class="elsevierStyleItalic">Fusarium</span> spp&#46; and <span class="elsevierStyleItalic">Scedosporium</span> spp&#46;&#44; since wide hyaline hyphae with 90&#176; branching are typically seen in mucormycosis&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The isolate was sent to a reference laboratory &#40;Corporaci&#243;n para Investigaciones Biol&#243;gicas &#91;Corporation for Biological Research&#93;&#44; in Medell&#237;n&#44; Colombia&#41;&#44; where it was confirmed to correspond to <span class="elsevierStyleItalic">Fusarium</span> spp&#46; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#41;&#46; The patient showed recovery from neutropenia&#44; and her fever and skin lesions disappeared&#46; A decision was made to complete 6 weeks of antifungal treatment and then continue with voriconazole for a year&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Final remarks</span><p id="par0015" class="elsevierStylePara elsevierViewall">This case presented the typical clinical signs of an invasive fungal infection caused by <span class="elsevierStyleItalic">Fusarium</span> spp&#46;&#59; the finding of macroconidia on the Gram stain of the blood cultures supported this diagnosis&#46; <span class="elsevierStyleItalic">Fusarium</span> spp&#46; and <span class="elsevierStyleItalic">Scedosporium</span> spp&#46; cause intravascular sporulation and skin lesions&#44; and blood cultures are usually positive in both cases but more commonly in infections due to <span class="elsevierStyleItalic">Fusarium</span> spp&#46; Infection with <span class="elsevierStyleItalic">Fusarium</span> spp&#46; presents with myalgia in up to 15&#37; of cases and examination under a microscope reveals macroconidia in the shape of a banana&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> typical findings in our case&#46; Although invasive sinusitis occurs in infections due to <span class="elsevierStyleItalic">Aspergillus</span> spp&#46; and zygomycetes&#44; their clinical behavior is more serious and rapidly progressive&#59; furthermore&#44; <span class="elsevierStyleItalic">Aspergillus</span> spp&#46; rarely presents with positive blood cultures&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Patients with haematological malignancies are at higher risk of invasive fungal infection due to filamentous fungi and the incidence is highest in patients with acute myeloid leukaemia&#46; In these cases&#44; soft tissue involvement may be a sign of infection with <span class="elsevierStyleItalic">Pseudomonas aeruginosa &#40;ecthyma gangrenosum&#41;</span>&#44; <span class="elsevierStyleItalic">Staphylococcus aureus</span> or filamentous fungi such as <span class="elsevierStyleItalic">Aspergillus</span> spp&#46;&#44; zygomycetes and <span class="elsevierStyleItalic">Fusarium</span> spp&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> or due to a non-infectious aetiology such as drug reactions&#44; Sweet&#39;s syndrome&#44; erythema multiforme or leukaemia cutis&#46; The presence of skin lesions in a &#34;bull&#39;s-eye&#34; pattern may lead to consideration of a diagnosis of disseminated fusariosis&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Invasive scedosporiosis is also accompanied by non-pruriginous&#44; erythematous and nodular skin lesions&#44; with a necrotic centre&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Invasive fusariosis is a rare disease&#44; with an incidence of 0&#46;1&#37;&#44; but a high mortality rate&#44; up to 53&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Fungaemia is a distinctive characteristic of invasive fusariosis compared to other opportunistic infections caused by fungi&#46; Prompt identification is required to quickly start treatment with effective antifungal agents &#40;voriconazole&#44; amphotericin B or posaconazole&#41;&#44; although rates of clinical response are modest&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> We wish to stress the importance of collaboration with the microbiology laboratory and morphological analysis of fungi&#44; which are necessary for differential diagnosis and appropriate treatment in patients with prolonged febrile neutropenia&#46;</p></span></span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical&#44; radiological and microbiological findings&#46; A&#46; Skin lesions in the form of round violaceous macules on the lower limbs&#46; B&#46; Computed tomography of the chest&#58; consolidation in the left upper lobe with no halo sign and no cavitation&#46; C&#46; Gram stain of blood cultures&#58; round and oval structures consistent with macroconidia&#46;</p>"
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        "texto" => "<p id="par0030" class="elsevierStylePara elsevierViewall">We would like to thank the Onc&#243;logos de Occidente &#91;Western Oncologists&#93; health institution&#46;</p>"
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es en pt

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