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Diagnosis at first sight
Multiple invasive abscesses syndrome in immunocompetent patient
Síndrome de abscesos múltiples invasivos en paciente inmunocompetente
Cándida Díaz-Brocheroa,b, Liliam Gisela Gerenaa,b, Jorge Alberto Cortésa,b,
Corresponding author
jacortesl@unal.edu.co

Corresponding author.
a Departamento de Medicina Interna, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia
b Unidad de Infectología, Hospital Universitario Nacional de Colombia, Bogotá, Colombia
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with local inflammatory signs in his left gluteal region&#46; Ophthalmology examination revealed palpebral oedema&#44; eyelid erythema&#44; ophthalmoplegia&#44; proptosis&#44; 360&#176; chemosis&#44; purulent discharge in the cul-de-sac&#44; 2-mm&#44; hyporeactive pupil&#44; with pain triggered by eye movements&#46; It was not possible to see the fundus of the eye &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Contrast magnetic resonance imaging of the skull with emphasis on orbits revealed rupture of the eyeball towards the superior aspect&#44; purulent material in the anterior and posterior chambers&#44; myositis of the extrinsic muscles of the eye&#44; and preseptal and palpebral inflammation &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#46; Contrast tomography of the abdomen showed hepatomegaly&#44; multiple bilateral cystic images predominantly in the right interpolar region 42<span class="elsevierStyleHsp" style=""></span>mm in size&#44; compatible with liver abscess in the right lobe &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>A&#41;&#46; Chest tomography revealed lung nodules in the right upper&#44; middle and lower lobes&#44; some of them cavitary &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>B&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Outcome</span><p id="par0015" class="elsevierStylePara elsevierViewall">The patient was started on antibiotics with ceftriaxone 2<span class="elsevierStyleHsp" style=""></span>g <span class="elsevierStyleSmallCaps">iv</span>&#47;12<span class="elsevierStyleHsp" style=""></span>h and vancomycin 1<span class="elsevierStyleHsp" style=""></span>g <span class="elsevierStyleSmallCaps">iv</span>&#47;12<span class="elsevierStyleHsp" style=""></span>h&#46; Blood cultures were positive for <span class="elsevierStyleItalic">Klebsiella pneumoniae</span> with the usual sensitivity pattern&#46; Antibiotic therapy was continued with ceftriaxone alone&#46; In the light of these findings&#44; enucleation of the left eyeball was performed without complications&#46; An extension study of the supratentorial brain parenchyma showed multiple hyperintense lesions in T2 and FLAIR&#44; with peripheral ring enhancement and central diffusion restriction&#44; less than a centimetre&#44; compatible with small abscesses of probable embolic origin &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41;&#46; Repeat blood cultures taken 48<span class="elsevierStyleHsp" style=""></span>h after antibiotic therapy were negative&#46; Transoesophageal echocardiogram showed no signs of vegetations&#46; A collection of 154 cm<span class="elsevierStyleSup">3</span> was documented in soft tissues in the patient&#39;s left gluteal region&#44; with disruption of the superficial fascia&#44; myositis in the musculature of the gluteal compartment and oedema of the deep fascia&#46; He was taken to theatre for surgical lavage on two separate occasions&#44; with Gram staining and cultures of secretions negative&#46; The final diagnosis was multiple abscesses due to hypervirulent <span class="elsevierStyleItalic">K&#46; pneumoniae&#46;</span></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Comments</span><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Klebsiella pneumoniae</span> is a member of the Enterobacteriaceae family of bacteria&#46; It is highly important from a clinical point of view and is responsible for both hospital- and community-acquired infections&#46; Most infections caused by this pathogen are associated with pneumonia or urinary tract or intra-abdominal infections&#46; However&#44; in the mid-1980s&#44; a different clinical syndrome emerged&#44; associated with hypervirulent subtypes of the bacteria and characterised by bacteraemia&#44; liver abscesses and serious disseminated infections&#46; Although initially described in Southeast Asia&#44; since its recognition&#44; cases have been reported worldwide&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> In the case we present here&#44; the patient denies travel to Southeast Asia or frequenting restaurants associated with that region&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Capsular serotypes K1 and K2 are considered the most virulent strains of <span class="elsevierStyleItalic">K&#46; pneumoniae</span>&#44; with K1 the strain most commonly found in patients with invasive liver abscess syndrome&#46; The hypermucosity phenotype has been cited as an important virulence factor of this pathogen&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> This is characterised by increased production of capsular polysaccharides&#44; which aids bacterial evasion of phagocytosis by macrophages and mononuclear cells&#46; At the molecular level&#44; specific virulence genes have been described&#44; such as rmpA &#40;responsible for regulating the mucoid phenotype&#41; and magA &#40;responsible for the capsular serotype K1&#41;&#44; both of which are determining factors of hypervirulence&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Diabetes mellitus has been identified as the most common risk factor&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a> The infection can compromise a number of different organs and can cause meningitis or brain abscesses&#44; endogenous endophthalmitis&#44; lung&#44; prostate and soft tissue abscesses&#44; necrotising fasciitis and osteomyelitis&#44; as in the case presented here&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#8211;9</span></a> Early percutaneous drainage of the liver abscess and targeted antibiotic treatment are the most important predictors in relation to decreasing mortality risk and a lower risk of complications&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p></span></span>"
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