Editorial
PET/CT to diagnose and manage patients with infectious diseases: “¡vamos a brillar, mi amor! (Let's shine, my love!)”
PET/TC para el diagnóstico y manejo de pacientes con enfermedades infecciosas: “¡vamos a brillar, mi amor! (¡Let's shine, my love!)”
Guillermo Cuervo
Department of Infectious Diseases, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
Read
320
Timeswas read the article
147
Total PDF
173
Total HTML
Share statistics
array:22 [ "pii" => "S2529993X22002593" "issn" => "2529993X" "doi" => "10.1016/j.eimce.2022.09.008" "estado" => "S300" "fechaPublicacion" => "2023-01-01" "aid" => "2655" "copyright" => "Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica" "copyrightAnyo" => "2022" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "edi" "cita" => "Enferm Infecc Microbiol Clin. 2023;41:1-2" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S2529993X22002179" "issn" => "2529993X" "doi" => "10.1016/j.eimce.2021.11.011" "estado" => "S300" "fechaPublicacion" => "2023-01-01" "aid" => "2525" "copyright" => "Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Enferm Infecc Microbiol Clin. 2023;41:3-10" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Impact of <span class="elsevierStyleSup">18</span>F-FDG-PET/CT on the management of <span class="elsevierStyleItalic">Staphylococcus aureus</span> bacteraemia: a retrospective observational study" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "3" "paginaFinal" => "10" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Impacto de la <span class="elsevierStyleSup">18</span>F-FDG-PET/TC en el manejo de la bacteriemia por <span class="elsevierStyleItalic">Staphylococcus aureus</span>: resultados de un estudio retrospectivo observacional" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Paula Suanzes, Rein Willekens, Mireia Puig-Asensio, María Nazarena Pizzi, Albert Roque, Marta Barios, Marc Simó, Dolors Rodríguez-Pardo, María Nieves Larrosa, Núria Fernández-Hidalgo, Benito Almirante" "autores" => array:11 [ 0 => array:2 [ "nombre" => "Paula" "apellidos" => "Suanzes" ] 1 => array:2 [ "nombre" => "Rein" "apellidos" => "Willekens" ] 2 => array:2 [ "nombre" => "Mireia" "apellidos" => "Puig-Asensio" ] 3 => array:2 [ "nombre" => "María Nazarena" "apellidos" => "Pizzi" ] 4 => array:2 [ "nombre" => "Albert" "apellidos" => "Roque" ] 5 => array:2 [ "nombre" => "Marta" "apellidos" => "Barios" ] 6 => array:2 [ "nombre" => "Marc" "apellidos" => "Simó" ] 7 => array:2 [ "nombre" => "Dolors" "apellidos" => "Rodríguez-Pardo" ] 8 => array:2 [ "nombre" => "María Nieves" "apellidos" => "Larrosa" ] 9 => array:2 [ "nombre" => "Núria" "apellidos" => "Fernández-Hidalgo" ] 10 => array:2 [ "nombre" => "Benito" "apellidos" => "Almirante" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0213005X21003918" "doi" => "10.1016/j.eimc.2021.11.013" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X21003918?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529993X22002179?idApp=UINPBA00004N" "url" => "/2529993X/0000004100000001/v4_202311091654/S2529993X22002179/v4_202311091654/en/main.assets" ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "PET/CT to diagnose and manage patients with infectious diseases: “<span class="elsevierStyleItalic">¡vamos a brillar, mi amor!</span> (Let's shine, my love!)”" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1" "paginaFinal" => "2" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Guillermo Cuervo" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Guillermo" "apellidos" => "Cuervo" "email" => array:1 [ 0 => "glcuervo@clinic.cat" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Department of Infectious Diseases, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "PET/TC para el diagnóstico y manejo de pacientes con enfermedades infecciosas: “<span class="elsevierStyleItalic">¡vamos a brillar, mi amor!</span> (¡Let's shine, my love!)”" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Widely used in the diagnosis and monitoring of oncologic pathologies, <span class="elsevierStyleSup">18</span>F-fluoro-2-deoxyglucose positron-emission tomography (FDG PET/CT) is a hybrid imaging technique that combines the good anatomical resolution of computed tomography with “functional” information provided by the accumulation of a tracer analog of glucose, the fluorine-18 cyclotron-produced radioisotope, which is avidly taken up by cells with intense glycolytic activity.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a> It has been shown that cells involved in inflammatory/infectious processes, particularly neutrophils and monocyte/macrophages, express high levels of glucose transport proteins and the hexokinases responsible for its phosphorylation.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">2</span></a> The accelerated transport of the radiotracer into these cells is proportional to the inflammatory/infectious activity, quantified in values of maximum standard uptake value (SUVmax) and whose expression in imaging corresponds to conspicuous shining areas of the affected zones.</p><p id="par0010" class="elsevierStylePara elsevierViewall">In addition to its usefulness in studying various inflammatory pathologies (such as large vessel vasculitis, sarcoidosis, rheumatic diseases, and inflammatory bowel diseases) and miscellaneous syndromes like fever of unknown origin,<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">3</span></a> in the last two decades we have witnessed a progressive incorporation of FDG PET/CT in the diagnosis and monitoring of many other infectious diseases. Firstly, its potential utility has been reported in infections caused by specific aetiologic agents, such as invasive fungal infections (e.g., invasive aspergillosis, chronic disseminated candidiasis, mucormycosis, histoplasmosis, scedosporiosis, acute pulmonary coccidioidomycosis, etc.)<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">4</span></a> or tuberculosis, where FDG PET/CT has been used for diagnose, staging, response evaluation as well as to potentially predict clinical progression in patients with latent TB infection.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Additionally, this tool has proven practical when there is a need to assess other complex infectious syndromes. There is much literature about its value in the study of musculoskeletal infections like osteomyelitis,<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">6</span></a> spondylitis (both pyogenic and tuberculous),<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">7</span></a> osteoarticular infections related with diabetic foot<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">8</span></a> and infections in prosthetic joints and periprosthetic spaces.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">9</span></a> Yet, perhaps, a scenario in which this test has shown greater diagnostic yield has been that related to the diagnosis and follow-up of vascular infections, both vascular graft infections<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">10</span></a> and, in particular, cardiac implantable electronic devices infections and prosthetic valve endocarditis.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> Indeed, its positivity has been incorporated as a major diagnostic criterion for prosthetic valve endocarditis in the modified Duke criteria in the latest guidelines of the European Heart Association.<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In the current issue of <span class="elsevierStyleItalic">Enfermedades Infecciosas y Microbiología Clínica</span>, it is presented the interesting work by Paula Suanzes et al., which explores the possible impact of the use of FDG PET/CT in the management of <span class="elsevierStyleItalic">Staphylococcus aureus</span> bacteraemia (SAB).<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">13</span></a> This microorganism continues to represent the leading cause of gram-positive bacteraemia, being associated with considerable morbidity and mortality. The optimal management of this heterogeneous clinical entity depends, to a large extent, on an accurate diagnosis of disease spread that would help to direct timely surgical maneuvers and/or trigger appropriate antibiotic treatment duration times. For this purpose, in addition to the evident usefulness of a thorough clinical history and physical evaluation, the search for a tool that helps quantify the initial severity of this disease can be compared to that of the “holy grail” for infectious disease specialists. Following this line of thought, additional microbiologic and biochemical data have been incorporated, including the time until blood culture positivity as a predictor of endocarditis and higher mortality,<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">14</span></a> and IL10 measure as a predictor of complicated bacteraemia and unfavorable outcomes.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">15</span></a> Varying diagnostic scores have also been created to guide transoesophageal echocardiography exploration and facilitate endocarditis diagnoses in specific cases.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">16</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The study by P. Suanzes et al.,<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">13</span></a> is a retrospective analysis of consecutive cases of SAB registered in a cohort from a large university hospital, the Vall d’Hebrón University Hospital in Barcelona, between 2013 and 2017. During that period, a highly selected group of patients (39 of 476; 8%) underwent FDG PET/CT as part of a diagnostic work-up for this pathology at the discretion of their treating physicians. The indication for the study was either the search for the initial bacteraemia source when unknown; the investigation of additional metastatic foci; or, finally, the evaluation of possible involvement of intravascular devices or cardiac prostheses. As a result of the test, it was possible to detect the source in 11 of 15 (73%) cases; reach a diagnosis of 30 additional foci in 22 of 39 (56%) patients, and diagnose or rule out infection of an intravascular device in 22 of 26 (85%) patients. The authors concluded that performing FDG PET/CT in patients with SAB could be useful for selected cases following an individualized approach. The study had some limitations, though, including its retrospective, single-center design; a relatively small number of cases evaluated; and no control group. The discretionary indication of the test also raised some additional questions. For example, how many patients considered to have low-risk SAB and without a need for FDG PET/CT were, in the end, cases of complicated bacteraemia with relapse at follow-up? Could these relapses have been avoided if a FDG PET/CT had been performed at the right time? In other words, could systematic FDG PET/CT be a useful tool for an earlier and more accurate detection of patients with complicated SAB, regardless of the initial risk attribution? The study design by P. Suanzes et al. cannot answer these questions. However, other observational studies exploring these issues have presented encouraging results,<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">17</span></a> albeit with obvious methodologic limitations.<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">18</span></a> Of note, some of these studies have found a surprisingly favorable impact on the prognosis of patients with SAB undergoing FDG PET-CT, with significant reductions in 90-day mortality in analyses adjusted for confounders.<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">17,19</span></a> Finally, there is currently a Spanish prospective study underway (Funder: IS Carlos III; ref. PI19/01116) and at least two international clinical trials (“TEPSTAR” study; <a href="ctgov:NCT03419221">NCT03419221</a> and “PET-SAB” study; <a href="ctgov:NCT05361135">NCT05361135</a>) that, hopefully, will shed light on the role of FDG PET/CT in the initial evaluation of these patients.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The peculiarity of FDG PET/CT in providing functional images of infectious activity undoubtedly positions the tool as promising for the diagnosis of disease spread. Given the high frequency of SAB and its ubiquity in different healthcare settings, an aspect that is surely relevant to debate in the future will be the accessibility of FDG PET-CT, currently being an expensive examination and only available in tertiary care centers. We will see in coming years if this technique is consolidated in the evaluation of patients with SAB and we will surely witness the progressive expansion of its use in evaluating a large number of infectious pathologies. Paraphrasing the lyrics of a famous Argentine rock band, we will request an FDG PET/CT for our patients with infections and “<span class="elsevierStyleItalic">¡a brillar, mi amor!”</span>.<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">20</span></a></p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:20 [ 0 => array:3 [ "identificador" => "bib0105" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EANM/SNMMI guideline for 18F-FDG use in inflammation and infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Jamar" 1 => "J. Buscombe" 2 => "A. Chiti" 3 => "P.E. Christian" 4 => "D. Delbeke" 5 => "K.J. Donohoe" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2967/jnumed.112.112524" "Revista" => array:6 [ "tituloSerie" => "J Nucl Med" "fecha" => "2013" "volumen" => "54" "paginaInicial" => "647" "paginaFinal" => "658" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23359660" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0110" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "FDG uptake and glucose transporter subtype expressions in experimental tumor and inflammation models" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Mochizuki" 1 => "E. Tsukamoto" 2 => "Y. Kuge" 3 => "K. Kanegae" 4 => "S. Zhao" 5 => "K. Hikosaka" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Nucl Med" "fecha" => "2001" "volumen" => "42" "paginaInicial" => "1551" "paginaFinal" => "1555" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11585872" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0115" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic performance of <span class="elsevierStyleSup">18</span>F-FDG PET/CT in infectious and inflammatory diseases according to published meta-analyses" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G. Treglia" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1155/2019/3018349" "Revista" => array:5 [ "tituloSerie" => "Contrast Media Mol Imaging" "fecha" => "2019" "volumen" => "2019" "paginaInicial" => "3018349" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31427907" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0120" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic contribution of positron emission tomography with <span class="elsevierStyleSup">18</span>F-fluorodeoxyglucose for invasive fungal infections" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Hot" 1 => "C. Maunoury" 2 => "S. Poiree" 3 => "F. Lanternier" 4 => "J.P. Viard" 5 => "P. Loulergue" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1469-0691.2010.03301.x" "Revista" => array:6 [ "tituloSerie" => "Clin Microbiol Infect" "fecha" => "2011" "volumen" => "17" "paginaInicial" => "409" "paginaFinal" => "417" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20636432" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0125" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculosis: role of nuclear medicine and molecular imaging with potential impact of neutrophil-specific tracers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. More" 1 => "M.J. Marakalala" 2 => "M. Sathekge" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3389/fmed.2021.758636" "Revista" => array:5 [ "tituloSerie" => "Front Med (Lausanne)" "fecha" => "2021" "volumen" => "8" "paginaInicial" => "758636" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34957144" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0130" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A meta-analysis of fluorodeoxyglucose-positron emission tomography versus scintigraphy in the evaluation of suspected osteomyelitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G.L. Wang" 1 => "K. Zhao" 2 => "Z.F. Liu" 3 => "M.J. Dong" 4 => "S.Y. Yang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MNM.0b013e32834b455c" "Revista" => array:6 [ "tituloSerie" => "Nucl Med Commun" "fecha" => "2011" "volumen" => "32" "paginaInicial" => "1134" "paginaFinal" => "1142" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21934545" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0135" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spine infections: the role of fluorodeoxyglucose positron emission tomography (FDG PET) in the context of the actual diagnosis guideline" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Boriani" 1 => "E. Zamparini" 2 => "M. Albrizio" 3 => "F. Serani" 4 => "G. Ciani" 5 => "L. Marconi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2174/1573405617666210916121046" "Revista" => array:6 [ "tituloSerie" => "Curr Med Imaging" "fecha" => "2022" "volumen" => "18" "paginaInicial" => "216" "paginaFinal" => "230" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34530718" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0140" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of the diagnostic accuracy of diffusion-weighted and dynamic contrast-enhanced MRI with 18F-FDG PET/CT to differentiate osteomyelitis from Charcot neuro-osteoarthropathy in diabetic foot" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Diez" 1 => "D. Fuster" 2 => "L. Morata" 3 => "F. Torres" 4 => "R. Garcia" 5 => "D. Poggio" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ejrad.2020.109299" "Revista" => array:5 [ "tituloSerie" => "Eur J Radiol" "fecha" => "2020" "volumen" => "132" "paginaInicial" => "109299" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33032207" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0145" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic performance of FDG PET or PET/CT in prosthetic infection after arthroplasty: a meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H. Jin" 1 => "L. Yuan" 2 => "C. Li" 3 => "Y. Kan" 4 => "R. Hao" 5 => "J. Yang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Q J Nucl Med Mol Imaging" "fecha" => "2014" "volumen" => "58" "paginaInicial" => "85" "paginaFinal" => "93" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24469570" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0150" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A systematic review and meta-analysis of <span class="elsevierStyleSup">18</span>F-fluoro-d-deoxyglucose positron emission tomography interpretation methods in vascular graft and endograft infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.I. Reinders Folmer" 1 => "G.C.I. von Meijenfeldt" 2 => "R.S. Te Riet Ook Genaamd Scholten" 3 => "M.J. van der Laan" 4 => "A.W.J.M. Glaudemans" 5 => "R.H.J.A. Slart" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jvs.2020.05.065" "Revista" => array:6 [ "tituloSerie" => "J Vasc Surg" "fecha" => "2020" "volumen" => "72" "paginaInicial" => "2174" "paginaFinal" => "2185" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32645420" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0155" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Improving the diagnosis of infective endocarditis in prosthetic valves and intracardiac devices with <span class="elsevierStyleSup">18</span>F-fluordeoxyglucose positron emission tomography/computed tomography angiography: initial results at an infective endocarditis referral center" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.N. Pizzi" 1 => "A. Roque" 2 => "N. Fernández-Hidalgo" 3 => "H. Cuéllar-Calabria" 4 => "I. Ferreira-González" 5 => "M.T. Gonzàlez-Alujas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/CIRCULATIONAHA.115.015316" "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2015" "volumen" => "132" "paginaInicial" => "1113" "paginaFinal" => "1126" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26276890" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0160" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Habib" 1 => "P. Lancellotti" 2 => "M.J. Antunes" 3 => "M.G. Bongiorni" 4 => "J.P. Casalta" 5 => "F. Del Zotti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/eurheartj/ehv319" "Revista" => array:6 [ "tituloSerie" => "Eur Heart J" "fecha" => "2015" "volumen" => "36" "paginaInicial" => "3075" "paginaFinal" => "3128" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26320109" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0165" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Suanzes P, Willekens R, Puig-Asensio M, Pizzi MN, Roque A, Barios M, et al. Impact of <span class="elsevierStyleSup">18</span>F-FDG-PET/CT on the management of <span class="elsevierStyleItalic">Staphylococcus aureus</span> bacteraemia: A retrospective observational study, Enferm Infecc Microbiol Clin, <a target="_blank" href="doi:10.1016/j.eimc.2021.11.013">doi:10.1016/j.eimc.2021.11.013</a>." ] ] ] 13 => array:3 [ "identificador" => "bib0170" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Time to blood culture positivity: an independent predictor of infective endocarditis and mortality in patients with <span class="elsevierStyleItalic">Staphylococcus aureus</span> bacteraemia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Siméon" 1 => "V. Le Moing" 2 => "S. Tubiana" 3 => "X. Duval" 4 => "D. Fournier" 5 => "J.P. Lavigne" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.cmi.2018.07.015" "Revista" => array:6 [ "tituloSerie" => "Clin Microbiol Infect" "fecha" => "2019" "volumen" => "25" "paginaInicial" => "481" "paginaFinal" => "488" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30036664" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0175" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Elevated serum interleukin-10 at time of hospital admission is predictive of mortality in patients with <span class="elsevierStyleItalic">Staphylococcus aureus</span> bacteremia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W.E. Rose" 1 => "J.C. Eickhoff" 2 => "S.K. Shukla" 3 => "M. Pantrangi" 4 => "S. Rooijakkers" 5 => "S.E. Cosgrove" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/infdis/jis552" "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "2012" "volumen" => "206" "paginaInicial" => "1604" "paginaFinal" => "1611" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22966128" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0180" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prediction rules for ruling out endocarditis in patients with <span class="elsevierStyleItalic">Staphylococcus aureus</span> bacteremia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T.W. van der Vaart" 1 => "J.M. Prins" 2 => "R. Soetekouw" 3 => "G. van Twillert" 4 => "J. Veenstra" 5 => "B.L. Herpers" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/cid/ciab632" "Revista" => array:7 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2022" "volumen" => "74" "paginaInicial" => "1442" "paginaFinal" => "1449" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34272564" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0889852919300854" "estado" => "S300" "issn" => "08898529" ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0185" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Integration of FDG-PET/CT in the diagnostic workup for <span class="elsevierStyleItalic">Staphylococcus aureus</span> bacteremia: a prospective interventional matched-cohort study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Ghanem-Zoubi" 1 => "O. Kagna" 2 => "J. Abu-Elhija" 3 => "M. Mustafa-Hellou" 4 => "M. Qasum" 5 => "Z. Keidar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/cid/ciaa929" "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2021" "volumen" => "73" "paginaInicial" => "e3859" "paginaFinal" => "e3866" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32639560" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0190" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleSup">18</span>F-FDG-PET/CT in <span class="elsevierStyleItalic">Staphylococcus aureus</span> bacteremia: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.T.P. Buis" 1 => "E. Sieswerda" 2 => "I.J.E. Kouijzer" 3 => "W.Y. Huynh" 4 => "G.L. Burchell" 5 => "M.A.H. Berrevoets" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s12879-022-07273-x" "Revista" => array:5 [ "tituloSerie" => "BMC Infect Dis" "fecha" => "2022" "volumen" => "22" "paginaInicial" => "282" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35331165" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0195" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "18F-FDG PET/CT optimizes treatment in <span class="elsevierStyleItalic">Staphylococcus aureus</span> bacteremia and is associated with reduced mortality" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Berrevoets" 1 => "I. Kouijzer" 2 => "E. Aarntzen" 3 => "M. Janssen" 4 => "L. De Geus-Oei" 5 => "H. Wertheim" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2967/jnumed.117.191981" "Revista" => array:6 [ "tituloSerie" => "J Nucl Med" "fecha" => "2017" "volumen" => "58" "paginaInicial" => "1504" "paginaFinal" => "1510" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28336786" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0200" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "La bestia pop” [Canción]. En Gulp!" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "I. Solari" 1 => "S. Beilinson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Wormo" "fecha" => "1985" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/2529993X/0000004100000001/v4_202311091654/S2529993X22002593/v4_202311091654/en/main.assets" "Apartado" => array:4 [ "identificador" => "64518" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Editorial" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/2529993X/0000004100000001/v4_202311091654/S2529993X22002593/v4_202311091654/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529993X22002593?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 October | 5 | 2 | 7 |
| 2024 September | 18 | 6 | 24 |
| 2024 August | 13 | 5 | 18 |
| 2024 July | 10 | 4 | 14 |
| 2024 June | 8 | 3 | 11 |
| 2024 May | 18 | 3 | 21 |
| 2024 April | 11 | 6 | 17 |
| 2024 March | 11 | 5 | 16 |
| 2024 February | 9 | 3 | 12 |
| 2024 January | 9 | 6 | 15 |
| 2023 December | 4 | 3 | 7 |
| 2023 November | 13 | 2 | 15 |
| 2023 October | 15 | 11 | 26 |
| 2023 September | 9 | 4 | 13 |
| 2023 August | 17 | 7 | 24 |
| 2023 July | 3 | 77 | 80 |
Show all
