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Original article
Epidemiology of Aeromonas spp. isolated from stool in a tertiary hospital in Cantabria, Northern Spain, in the last five years
Epidemiología de Aeromonas spp. aisladas de heces en un hospital terciario en Cantabria, norte de España, en los últimos 5 años
Carlos Ruiz de Alegría-Puig
Corresponding author
carlosrdap@hotmail.com

Corresponding author.
, Marta Fernández-Martínez, Ana De Malet Pintos-Fonseca
Microbiology Service, University Hospital Marqués de Valdecilla-IDIVAL, Santander, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The genus <span class="elsevierStyleItalic">Aeromonas</span> belongs to the <span class="elsevierStyleItalic">Aeromonadaceae</span> family and comprises a group of Gram-negative bacteria widely distributed in aquatic environments&#44; but its great capacity for adaptation also makes <span class="elsevierStyleItalic">Aeromonas</span> species able to colonize terrestrial environments&#44; so these microorganisms can be identified from different sources&#44; such as soils&#44; plants&#44; fruits&#44; vegetables&#44; birds&#44; reptiles&#44; amphibians&#44; among others&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> The genus <span class="elsevierStyleItalic">Aeromonas</span> comprises of two different groups of bacteria&#46; One is non-motile psychrophilic <span class="elsevierStyleItalic">Aeromonas salmonicida</span> and the other group comprising of three mesophilic motile spp&#46; <span class="elsevierStyleItalic">Aeromonas hydrophila</span>&#44; <span class="elsevierStyleItalic">Aeromonas caviae</span>&#44; and <span class="elsevierStyleItalic">Aeromonas sobria</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">2</span></a> Some species of <span class="elsevierStyleItalic">Aeromonas</span> are known to be pathogenic in both mammals and reptiles or fish&#44; particularly in humans&#44; Aeromonads&#44; are known to cause gastroenteritis and extraintestinal diseases such as septicemia&#44; skin&#44; eye&#44; wound and respiratory tract infections&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a> It has not always been easy to identify <span class="elsevierStyleItalic">Aeromonas</span> spp&#46; by traditional biochemical tests in clinical microbiology laboratories&#46; Today&#44; thanks to the new technologies used such as mass spectrometry&#44; which is increasingly used because it is faster&#44; simpler and with high precision with respect to traditional methods&#44; make it easier identifying them&#46; Some <span class="elsevierStyleItalic">Aeromonas</span> species are found forming part of the human gastrointestinal microbiota&#44; varying the rates of frequency from 0&#37; to 4&#37; in persons with no disease to 0&#46;8&#8211;7&#46;4&#37; in persons with diarrheal illness&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a> The prevalence in case of diarrhea in pediatric age is around 4&#46;6&#37;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">5</span></a> and also it has been described as a co-pathogen at 1&#46;9&#8211;57&#46;7&#37; in pediatric age&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The objective of this study was to know the epidemiological distribution of <span class="elsevierStyleItalic">Aeromonas</span> spp&#46; in our health area&#44; to determine the most significant symptom associated with Aeromonas&#44; frequency of association as co-pathogen&#44; identification of existing species as well as age of distribution or existence of seasonal association in our environment&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><p id="par0015" class="elsevierStylePara elsevierViewall">Retrospective descriptive study&#44; through the laboratory information system &#40;SIL&#41;&#44; of isolates of <span class="elsevierStyleItalic">Aeromonas</span> spp&#46; in stool between 2016 and 2020 in the Microbiology Department of the University Hospital Marqu&#233;s de Valdecilla&#44; Santander&#44; that serves a total of 313&#46;040 census population&#46; The protocol for these isolates included inoculated on Yersinia Selective Agar &#40;CIN Agar&#59; BD&#44; Heidelberg&#44; Germany&#41; and incubated at 37<span class="elsevierStyleHsp" style=""></span>&#176;C for 24<span class="elsevierStyleHsp" style=""></span>h&#46; Identification was performed by MALDI-TOF system &#40;Vitek-MS&#174;&#44; BioMerieux&#41; and most of them were confirmed by multiplex PCR developed by Perssons S et al&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> The statistical analysis was performed by Fisher statistical test with SPSS program&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0020" class="elsevierStylePara elsevierViewall">A total of 366 isolates of <span class="elsevierStyleItalic">Aeromonas</span> spp&#46; were analyzed&#46; It was 1&#46;1&#37; of the total of coprocultures analyzed and 15&#46;8&#37; of all enteropathogens identified in the years under study&#44; behind <span class="elsevierStyleItalic">Campylobacter</span> spp&#46; &#40;57&#46;8&#37;&#41; and <span class="elsevierStyleItalic">Salmonella enterica</span> &#40;25&#46;2&#37;&#41;&#44; but at the same time far ahead of other genera such as <span class="elsevierStyleItalic">Yersinia enterocolitica</span> &#40;1&#46;3&#37;&#41; or <span class="elsevierStyleItalic">Shigella</span> spp&#46; &#40;0&#46;5&#37;&#41;&#46; <span class="elsevierStyleItalic">A&#46; caviae</span> was the most prevalent species &#40;78&#46;5&#37;&#41;&#44; at a large distance from other species such as <span class="elsevierStyleItalic">A&#46; sobria&#47;veronii</span> &#40;9&#46;0&#37;&#41; or <span class="elsevierStyleItalic">A&#46; hydrophila</span> &#40;2&#46;4&#37;&#41;&#46; Without taking into account the enteropathogenic <span class="elsevierStyleItalic">Escherichia coli</span> serotypes that are identified at the express request of the clinician&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">No significant differences were found in sex distribution &#40;190&#59; 52&#46;0&#37; women&#41; nor in the frequency of infection in adults &#40;&#62;16 years&#41; with respect to pediatric age &#40;185&#59; 50&#46;5&#37;&#41;&#44; with a mean age of infection of 34 years &#40;range 0&#8211;98 years&#41;&#46; Diarrhea was found as the most common referred symptom &#40;162&#59;44&#46;0&#37;&#41;&#44; followed by acute gastroenteritis &#40;78&#59; 21&#46;3&#37;&#41;&#46; A total of 58 co-infections were identified &#40;15&#46;93&#37;&#41;&#44; being significantly more frequent in pediatric ages &#40;49&#59;84&#46;5&#37;&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41; and mostly associated with <span class="elsevierStyleItalic">Campylobacter</span> spp&#46; &#40;75&#46;9&#37; of the total co-infections and 75&#46;5&#37; in pediatric age&#41;&#46; <span class="elsevierStyleItalic">A&#46; caviae</span> &#40;51&#44; 87&#46;9&#37;&#41; was the most frequently isolated species as a copathogen regardless of age&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Antimicrobial sensitivity to the most commonly used antibiotics showed good activity to cotrimoxazole &#40;92&#46;9&#37;&#41;&#44; ciprofloxacin &#40;86&#46;1&#37;&#41; and cefepime &#40;98&#46;9&#37;&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The 52&#46;0&#37; of the studied samples were requested from health centers&#44; followed by emergency service for both pediatric 12&#46;6&#37; and adult age 10&#46;9&#37;&#46; The most frequently observed symptom was diarrhea 44&#46;2&#37;&#44; being bloody in 4&#46;6&#37; of cases&#44; followed by acute gastroenteritis in 21&#46;3&#37;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In the cases accumulated by months&#44; there is a clear increase in the incidence in summer&#44; especially in the month of August &#40;15&#46;8&#37;&#41;&#44; being significant this increase for adults &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#41; and children &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41; &#40;see <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Aeromonas</span> spp&#46; ranks third in terms of incidence of enteropathogenic bacteria in our area of influence&#44; as opposed to other series in the 1990s&#44; possibly due to the fact that in those years it was not yet considered a primary pathogen&#46; But in more recent series this enteropathogen does not appear possibly because it is not included in the molecular syndromic panels of recent massive introduction in clinical diagnostic laboratories&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> It is true that its finding in association with another enteropathogen&#44;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">7</span></a> as well as its known role as part of the usual intestinal microbiota<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a> or doubts about its possible pathogenicity mechanism&#44;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">11</span></a> relegate it to the identification of classical enteropathogens&#46; Even more in case of isolation of <span class="elsevierStyleItalic">A&#46; caviae</span> in pediatric age where it is not given much attention&#44; although published series show that <span class="elsevierStyleItalic">A&#46; caviae</span> is the most frequently isolated species<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a> a fact that coincides with our population&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In the present study&#44; <span class="elsevierStyleItalic">Campylobacter</span> spp&#46; showed a significant association with <span class="elsevierStyleItalic">Aeromonas</span> spp&#46; particularly in the younger age group&#44; as other studies in our country&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a> Is reported <span class="elsevierStyleItalic">Aeromonas</span> spp&#46; as a part of a polymicrobial infection&#44; which raises the question of whether it is behaving as a nonpathogenic &#8220;co-traveler&#8221;&#44; perhaps acquired from the same source as the true pathogen&#44; or is interacting with other agents to cause disease&#46; The almost exclusive appearance of the species <span class="elsevierStyleItalic">A&#46; caviae</span> and its lower virulence can indicate its appearance in feces as a colonizer&#46; Pathogens commonly reported in literature to coexist with <span class="elsevierStyleItalic">Aeromonas</span> are rotavirus&#44; <span class="elsevierStyleItalic">Shigella</span>&#44; <span class="elsevierStyleItalic">Campylobacter</span>&#44; and <span class="elsevierStyleItalic">Escherichia coli</span> O157&#58;H7&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">12&#44;14</span></a> This feature in identifying <span class="elsevierStyleItalic">Aeromonas</span> can help the microbiologist and pediatrician be alert to a possible primary enteropathogen&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">But the pathogenicity is clear both by its association with diarrhea&#44; as in this and other works and by the identification of virulence genes especially in species such as <span class="elsevierStyleItalic">Aeromonas hydrophila</span> or <span class="elsevierStyleItalic">Aeromonas sobria</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">We can conclude that <span class="elsevierStyleItalic">Aeromonas</span> spp&#46; is an enteropathogen that appears very frequently in the feces of patients with digestive symptoms both in our health area and in other published case series&#46; Circumstance that should be taken into account when deciding to diagnose patients with gastrointestinal pathology with syndromic panels in which <span class="elsevierStyleItalic">Aeromonas</span> spp is not included&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The appearance of <span class="elsevierStyleItalic">Aeromonas</span> spp&#46; in feces of patients at an early age&#44; in many cases&#44; is associated with the appearance of a classic primary copathogen&#44; in our case <span class="elsevierStyleItalic">Campylobacter</span> spp&#46; This finding could alert in the active search by molecular techniques for primary pathogens if they are not isolated by stool culture&#44; especially in those cases that are associated with diarrhea&#44; bloody diarrhea or acute gastroenteritis&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Transparency declarations</span><p id="par0070" class="elsevierStylePara elsevierViewall">All authors have nothing to declare&#46; This study has not been financially supported by any Diagnostic&#47;Pharmaceutical company&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Ethical approval</span><p id="par0075" class="elsevierStylePara elsevierViewall">Not applicable&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Funding</span><p id="par0080" class="elsevierStylePara elsevierViewall">This study was supported by <span class="elsevierStyleGrantSponsor" id="gs1">Plan Nacional de I&#43;D&#43;i 2013&#8211;2016</span>&#44; <span class="elsevierStyleGrantSponsor" id="gs2">Instituto de Salud Carlos III</span>&#44; <span class="elsevierStyleGrantSponsor" id="gs3">Subdirecci&#243;n General de Redes y Centros de Investigaci&#243;n Cooperativa</span>&#44; <span class="elsevierStyleGrantSponsor" id="gs4">Ministerio de Econom&#237;a y Competitividad</span>&#44; <span class="elsevierStyleGrantSponsor" id="gs5">Spanish Network for Research in Infectious Diseases</span> &#40;<span class="elsevierStyleGrantNumber" refid="gs5">REIPI RD16&#47;0016&#47;0007</span>&#41;&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflict of interest</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The role of <span class="elsevierStyleItalic">Aeromonas</span> species in gastrointestinal disease is controversial&#46; The aim of this study was to know the epidemiological distribution of <span class="elsevierStyleItalic">Aeromonas</span> spp&#46; isolated from stool in our health area&#44; determine the existence of diarrhea as a significant symptom&#44; identification of existing species in our environment and association as co-pathogen&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">It was a retrospective descriptive study of isolates of <span class="elsevierStyleItalic">Aeromonas</span> spp&#46; in feces &#40;2016&#8211;2020&#41;&#46; The protocol for these isolates included coproculture&#44; identification by MALDI-TOF &#40;Vitek-MS&#174;&#44; BioMerieux&#41; and confirmation by multiplex PCR&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A total of 366 <span class="elsevierStyleItalic">Aeromonas</span> spp&#46; isolates were analyzed being <span class="elsevierStyleItalic">Aeromonas caviae</span> the most prevalent species &#40;289&#44; 78&#46;7&#37;&#41;&#46; A total of 58 &#40;15&#46;8&#37;&#41; co-infections were identified&#44; being more frequent in pediatric age &#40;49&#59;84&#46;5&#37;&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; and mostly associated with <span class="elsevierStyleItalic">Campylobacter</span> spp&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Discussion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Aeromonas</span> spp&#46; prove to be a gastrointestinal pathogen more frequently associated with co-infections in pediatric age&#44; evidencing its appearance especially with <span class="elsevierStyleItalic">Campylobacter</span> spp&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El papel de las especies de <span class="elsevierStyleItalic">Aeromonas</span> en la enfermedad gastrointestinal es muy controvertido&#46; El objetivo de este estudio fue conocer la distribuci&#243;n epidemiol&#243;gica de <span class="elsevierStyleItalic">Aeromonas</span> spp&#46; aislada de heces en nuestra &#225;rea de salud&#44; determinar la existencia de diarrea como s&#237;ntoma significativo&#44; la identificaci&#243;n de especies existentes en nuestro entorno y la asociaci&#243;n como copat&#243;geno&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se trata de un estudio descriptivo retrospectivo de aislados de <span class="elsevierStyleItalic">Aeromonas</span> spp&#46; en heces &#40;2016-2020&#41;&#46; El protocolo para estos aislamientos inclu&#237;a coprocultivo&#44; la identificaci&#243;n por MALDI-TOF &#40;VITEK&#174;MS&#44; bioM&#233;rieux&#41; y la confirmaci&#243;n por PCR multiplex&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se analizaron un total de 366 aislados de <span class="elsevierStyleItalic">Aeromonas</span> spp&#46;&#44; siendo <span class="elsevierStyleItalic">Aeromonas caviae</span> la especie m&#225;s prevalente &#40;289&#59; 78&#44;7&#37;&#41;&#46; Se identificaron un total de 58 &#40;15&#44;8&#37;&#41; coinfecciones&#44; siendo significativamente m&#225;s frecuentes en edades pedi&#225;tricas &#40;49&#59; 84&#44;5&#37;&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41; y asociadas principalmente con <span class="elsevierStyleItalic">Campylobacter</span> spp&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Discusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Aeromonas</span> spp&#46; resulta ser un pat&#243;geno gastrointestinal que se asocia con mayor frecuencia a coinfecciones en la edad pedi&#225;trica&#44; evidenciando su aparici&#243;n especialmente con <span class="elsevierStyleItalic">Campylobacter</span> spp&#46;</p></span>"
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                            0 => "R&#46;B&#46; Gon&#231;alves Pessoa"
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                            3 => "M&#46;T&#46; Dos Santos Correia"
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

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