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Anisocoria and optic neuritis associated with Mycoplasma pneumoniae infection
Anisocoria y neuritis óptica en infección por Mycoplasma pneumoniae
Diego Gayoso-Canteroa,
Corresponding author
gayosocan@gmail.com

Corresponding author.
, Claudia Sarró-Fuentesb, Manuel Barón-Rubioc, Juan Emilio Losa-Garcíaa
a Servicio de Medicina Interna, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain
b Servicio de Dermatología, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain
c Servicio de Neurología, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain
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the patient had not improved and attended Accident &#38; Emergency&#59; he had tachypnoea&#44; with a baseline saturation of 88&#37;&#44; which rose to 95&#37; with nasal cannula at 2 lpm&#44; HR 46 bpm&#44; blood pressure 124&#47;68 and rhonchi in the upper right lung field&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Tests revealed leucocytosis with neutrophilia&#44; coagulopathy &#40;INR 1&#46;3&#41; and C-reactive protein of 103<span class="elsevierStyleHsp" style=""></span>mg&#47;l&#44; and a repeat chest X-ray showed no changes&#46; Treatment was escalated to ceftriaxone 2<span class="elsevierStyleHsp" style=""></span>g&#47;24<span class="elsevierStyleHsp" style=""></span>h with levofloxacin 500<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h and the patient was admitted to internal medicine&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">On day three of admission he developed anisocoria&#44; with greater mydriasis in his left eye&#46; CT scan of the brain showed no acute intracranial findings&#46; Pilocarpine eye drop test showed involvement of the left third cranial nerve&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">CT angiogram of the head ruled out vascular injury and MRI ruled out cavernous sinus pathology&#44; showing right maxillary sinusitis and left ethmoid sinus retention cyst &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#44; lower&#41;&#46; After 24<span class="elsevierStyleHsp" style=""></span>h&#44; the anisocoria resolved spontaneously&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Multiplex PCR was carried out on nasopharyngeal exudate and sputum&#44; which was positive for <span class="elsevierStyleItalic">M&#46; pneumoniae</span> and negative for coronavirus&#44; MERS-CoV&#44; rhinovirus&#47;enterovirus&#44; influenza and parainfluenza virus&#44; metapneumovirus&#44; adenovirus and respiratory syncytial virus&#46; Serum was also positive for <span class="elsevierStyleItalic">M&#46; pneumoniae</span> IgM&#46; HIV&#44; syphilis and hepatotropic virus serologies were all negative&#46; Azithromycin 500<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h for seven days was prescribed&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Four days later&#44; the patient consulted once more due to loss of visual acuity in his left eye&#46; Visual field testing revealed a diffuse loss of sensitivity with a superior altitudinal visual field defect in the left eye and visual acuity of 0&#46;5&#46; Lumbar puncture ruled out infection of the central nervous system&#46; As parainfectious retrobulbar optic neuritis was suspected&#44; he was started on corticosteroid therapy and made a full recovery&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">At subsequent check-ups&#44; the electroencephalogram&#44; cervical spine magnetic resonance imaging and brain magnetic resonance angiography were normal&#44; and the follow-up lumbar puncture showed no oligoclonal bands&#46; Blood aquaporin 4 antibodies and myelin oligodendrocyte glycoprotein antibodies were negative&#44; but he had a mild sustained IgG2 deficiency&#46; After seven weeks&#44; he continued to be IgM positive&#44; with IgG seroconversion against <span class="elsevierStyleItalic">M&#46; pneumoniae</span> &#40;signal 1&#46;41&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The incidence of central nervous system complications due to <span class="elsevierStyleItalic">Mycoplasma</span> spp&#46; has not been established&#59; it ranges from 1&#37; to 7&#37; in hospitalised patients&#44; with the mortality rate as high as 10&#37;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46; Over half of cases are found in patients between 6 and 21 years of age<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#44; but it also occurs in adults&#46; Parainfectious neuritis usually occurs bilaterally and is more active in children<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#44; and up to 20&#37; may have no prior respiratory infection<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">There are several mechanisms involved in the neurological complications&#44; none of which is exclusive&#46; There may be direct cell damage following haematogenous spread of the microorganism reaching the central nervous system&#46; When the bacteria damages cells&#44; the innate immune response is activated&#44; attracting different cytokines such as IL 18&#44; which activates helper T cells 1 and 2&#44; or IL 8&#44; which attracts neutrophils&#46; It can be mediated by immune complexes due to antigenic elements&#44; which bind to the patient&#39;s macrophages and monocytes&#44; initiating immune reactions due to the antigenic similarities between <span class="elsevierStyleItalic">M&#46; pneumoniae</span> and brain parenchyma antigens<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46; Vascular damage is also possible<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The incidence of <span class="elsevierStyleItalic">Mycoplasma</span> spp&#46; infections is increasing in patients with hypogammaglobulinaemia&#44; which indicates compromise of humoral immunity in the pathogenesis of these cases<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#46; Antibodies inhibit the growth of <span class="elsevierStyleItalic">M&#46; pneumoniae in vitro</span>&#44; preventing proliferation on the surface of colonised mucosa<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#44; without affecting neutrophil opsonisation<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Our patient had optic neuritis as a rare complication in <span class="elsevierStyleItalic">M&#46; pneumoniae</span> infections&#46; It is likely that partial IgG2 deficiency facilitated infection and cell mimicry led to the neurological symptoms&#46; We need to be aware of the association between hypogammaglobulinaemia and the risk of <span class="elsevierStyleItalic">M&#46; pneumoniae</span> infection&#44; as these patients can suffer from more severe and prolonged illnesses and develop more complications<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&#46;</p></span>"
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