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Scientific letter
Molecular characterization of Staphylococcus aureus causing menstrual toxic shock syndrome in a young woman
Caracterización molecular de Staphylococccus aureus, agente causal del síndrome del shock tóxico menstrual en una mujer joven
Maria Font-Fonta, Alba Bellés-Bellésa,
Corresponding author
abelles.lleida.ics@gencat.cat

Corresponding author.
, Rosa Fernández-Fernándezb, Carmen Torresb
a Sección Microbiología Hospital Universitari Arnau de Vilanova, Lleida, Spain
b Área Bioquímica y Biología Molecular, Universidad de La Rioja, Logroño, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Toxic shock syndrome &#40;TSS&#41; is a rare life-threatening disease first described by Todd and Fishaut in 1978&#46; The most characteristic symptoms are fever&#44; rash&#44; hypotension&#44; desquamation and the involvement of multiple organ systems&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Menstrual TSS &#40;mTSS&#41; is defined when it appears from the beginning of the menstruation and up to four days after&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> mTSS incidence has been reported to be 0&#46;69 in 100&#44;000 menstruating women per year and has been associated with high morbidity and mortality rate in previously healthy women&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">mTSS is caused by superantigen-producing <span class="elsevierStyleItalic">Staphylococcus aureus</span> &#40;SA&#41; or group A <span class="elsevierStyleItalic">Streptococcus&#44;</span> and has been associated with the use of different vaginal devices as tampons or menstrual cups&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> SA superantigen&#44; named toxic shock syndrome toxin-1 &#40;TSST-1&#41;&#44; is encoded by <span class="elsevierStyleItalic">tst</span> gene and is responsible for mTSS by its ability to trigger excessive and non-conventional T-cell activation with consequent downstream activation of other cell types&#44; and cytokine&#47;chemokine release&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">We report a case of a 15-year-old menstruating woman who was hospitalized in the Intensive Care Unit &#40;ICU&#41; with suspicion of septic shock in the context of purulent vaginal discharge&#46; The presented symptoms were malaise&#44; fever &#40;38&#46;9<span class="elsevierStyleHsp" style=""></span>&#176;C&#41;&#44; sore throat&#44; diarrhoea&#44; rash and painful genital ulcers of 3 days of evolution&#46; Physical examination was remarkable for a low blood pressure &#40;80&#47;50<span class="elsevierStyleHsp" style=""></span>mmHg&#41;&#44; diffuse erythematous macular rash and conjunctival hyperaemia&#46; Laboratory assessments on admission revealed elevated inflammatory markers &#40;value obtained &#8211; reference range&#41; &#40;CRP 218<span class="elsevierStyleHsp" style=""></span>mg&#47;L &#8211; 0&#46;2&#8211;5<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#59; PCT 26&#46;65<span class="elsevierStyleHsp" style=""></span>ng&#47;mL &#8211; &#60;0&#46;05<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41;&#44; acute renal injury &#40;creatinine 3<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#8211; 0&#46;51&#8211;0&#46;95<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#44; anaemia &#40;haemoglobin 10&#46;5<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#41;&#44; thrombocytopenia &#40;101<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span><span class="elsevierStyleHsp" style=""></span>platelets&#47;L&#41; and associated coagulopathy &#40;D-dimers 6634<span class="elsevierStyleHsp" style=""></span>ng&#47;mL &#8211; 0&#8211;243<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41;&#46; Upon ICU admission&#44; several samples were sent to the laboratory for bacteriological study and SA was isolated from vaginal&#44; nasal&#44; rectal and axillary swabs&#44; pointing out the mTSS as the most probable diagnosis&#46; Blood cultures remained negative&#46; Antibiotic susceptibility testing was performed with Panel Type 33 of MicroScan WalkAway using the breakpoints recommended by The European Committee on Antimicrobial Susceptibility Testing &#40;<a href="http://www.eucast.org/">http&#58;&#47;&#47;www&#46;eucast&#46;org</a>&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The four SA strains showed the same resistance phenotype &#40;penicillin&#44; erythromycin and clindamycin inducible &#40;MLSBi&#41;&#41;&#59; they were sent to the University of La Rioja for detection of &#40;1&#41; virulence genes&#58; <span class="elsevierStyleItalic">tst</span> &#40;encoding TSST-1 toxin&#41;&#44; <span class="elsevierStyleItalic">pvl</span> &#40;encoding Panton-Valentine-Leucocidin&#41; and <span class="elsevierStyleItalic">sea</span>&#44; <span class="elsevierStyleItalic">seb</span> and <span class="elsevierStyleItalic">sec</span> &#40;encoding enterotoxins A&#44; B and C&#41;&#59; &#40;2&#41; antimicrobial resistance genes &#40;<span class="elsevierStyleItalic">blaZ</span> and <span class="elsevierStyleItalic">ermA&#47;ermB&#47;ermC&#47;ermT</span>&#41;&#59; &#40;3&#41; molecular typing &#40;<span class="elsevierStyleItalic">spa</span>-typing and multi-locus-sequence-typing&#41;&#59; &#40;4&#41; immune evasion cluster &#40;IEC&#41; system&#44; present in most human SA isolates &#40;the IEC system includes seven different types&#58; from A to E&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The four isolates were typed as MSSA-CC30-t012 and IEC-type A&#44; they carried the <span class="elsevierStyleItalic">tst</span> gene &#40;verified by PCR&#47;sequencing&#41; but not <span class="elsevierStyleItalic">pvl</span> and they carried the <span class="elsevierStyleItalic">blaZ</span> gene &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#59; they also carried the <span class="elsevierStyleItalic">sea</span> gene but not <span class="elsevierStyleItalic">seb</span> or <span class="elsevierStyleItalic">sec</span> genes&#46; The prevalence of CC30 SA has been considerably reported in several European countries<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#44;8</span></a>&#59; and a study performed in the UK revealed a strong association of the <span class="elsevierStyleItalic">tst</span>-positive CC30 SA lineage with mTSS and TSS cases&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">However&#44; mTSS primarily remains a clinical diagnosis&#44; and indeed&#44; the isolation of SA <span class="elsevierStyleItalic">tst</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">&#43;</span></span> is not required for diagnosis of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Moreover&#44; in Spain and other countries in Europe&#44; TSS is not a notifiable illness&#44; so the clinical&#44; microbiological&#44; and toxigenic features of TSS remain poorly described&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patient was empirically treated with cefotaxime and metronidazole&#46; Metronidazole was discontinued and clindamycin was added when SA was reported&#46; After antibiotic susceptibility testing&#44; treatment changed from cefotaxime to cloxacillin and&#44; since the patient was presenting a favourable evolution&#44; clindamycin was maintained&#46; The patient was discharged from ICU setting 2 days after admission&#44; and sent home on the 8th day of hospitalization&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">This case evidences the persistence of mTSS cases&#44; which may be fatal&#44; even leading to patient&#39;s death&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> Thanks to the early diagnosis and the prompt implementation of vital support and antibiotic treatment&#44; our patient had a good outcome&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conclusions</span><p id="par0045" class="elsevierStylePara elsevierViewall">Due to its rarity and initially unspecific symptoms&#44; patients with mTSS are at risk of misdiagnosis&#46; Even though molecular methods are not available in many laboratories&#44; its implementation should be considered since they represent a possibility for faster diagnostics&#44; and to obtain more information for the clinical and epidemiological surveillance of mTSS&#47;TSS-associated SA lineages&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Finance</span><p id="par0055" class="elsevierStylePara elsevierViewall">The experimental work performed in the University of La Rioja was financed by project of MCIN&#47;AEI&#47;10&#46;13039&#47;501100011033 of Spain&#46; R&#46; Fernandez-Fern&#225;ndez has a predoctoral contract from the Ministry of Spain &#40;FPU18&#47;05438&#41;&#46;</p></span></span>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Sample&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Molecular typing</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Antimicrobial resistance</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Virulence genes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">IEC-type&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">spa</span>-type&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">CC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Phenotype<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Genotype&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vaginal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">t012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CC30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PEN&#44; ERY&#44; CLI<span class="elsevierStyleSup">b</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">blaZ</span>&#44; <span class="elsevierStyleItalic">erm</span>&#40;A&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">tst&#44; <span class="elsevierStyleBold">sea</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nasal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">t012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CC30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PEN&#44; ERY&#44; CLI<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">blaZ</span>&#44; <span class="elsevierStyleItalic">erm</span>&#40;A&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">tst&#44; <span class="elsevierStyleBold">sea</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rectal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">t012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CC30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PEN&#44; ERY&#44; CLI<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">blaZ</span>&#44; <span class="elsevierStyleItalic">erm</span>&#40;A&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">tst&#44; <span class="elsevierStyleBold">sea</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Axillary&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">t012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CC30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PEN&#44; ERY&#44; CLI<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">blaZ</span>&#44; <span class="elsevierStyleItalic">erm</span>&#40;A&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">tst&#44; <span class="elsevierStyleBold">sea</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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              "identificador" => "tblfn0005"
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">PEN&#58; penicillin&#59; ERY&#58; erythromycin&#59; CLI&#58; clindamycin&#46;</p> <p class="elsevierStyleNotepara" id="npar0010"><span class="elsevierStyleSup">b</span>Inducible resistance&#46;</p>"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Characterization of the four <span class="elsevierStyleItalic">Staphylococcus aureus</span> isolates recovered from the patient with menstrual toxic shock syndrome&#46;</p>"
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    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Toxic-shock syndrome associated with phage-group-I staphylococci"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Todd"
                            1 => "M&#46; Fishaut"
                            2 => "F&#46; Kapral"
                            3 => "T&#46; Welch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1978"
                        "volumen" => "2"
                        "paginaInicial" => "1116"
                        "paginaFinal" => "1118"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2903328"
                            "web" => "Medline"
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            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Centers for Disease Control and Prevention&#46; Toxic shock syndrome &#40;other than streptococcal&#41; &#40;TSS&#41; 2011 case definition&#46; Available from&#58; <a target="_blank" href="http://www.cdc.gov/nndss/conditions/toxic-shock-syndrome-other-than-streptococcal/case-definition/2011/">http&#58;&#47;&#47;www&#46;cdc&#46;gov&#47;nndss&#47;conditions&#47;toxic-shock-syndrome-other-than-streptococcal&#47;case-definition&#47;2011&#47;</a>&#46;"
                ]
              ]
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            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Staphylococcal toxic shock syndrome 2000&#8211;2006&#58; epidemiology&#44; clinical features&#44; and molecular characteristics"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;S&#46; DeVries"
                            1 => "L&#46; Lesher"
                            2 => "P&#46;M&#46; Schlievert"
                            3 => "T&#46; Rogers"
                            4 => "L&#46;G&#46; Villaume"
                            5 => "R&#46; Danila"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "PLOS ONE"
                        "fecha" => "2011"
                        "volumen" => "6"
                        "paginaInicial" => "e22997"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Device-associated menstrual toxic shock syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;M&#46; Schlievert"
                            1 => "C&#46;C&#46; Davis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Clin Microbiol Rev"
                        "fecha" => "2020"
                        "volumen" => "33"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of vaginal microbial communities on colonization by <span class="elsevierStyleItalic">Staphylococcus aureus</span> with the gene for toxic shock syndrome toxin 1 &#40;TSST-1&#41;&#58; a case&#8211;control study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;D&#46; Pierson"
                            1 => "M&#46;A&#46; Hansmann"
                            2 => "C&#46;C&#46; Davis"
                            3 => "L&#46;J&#46; Forney"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/femspd/fty015"
                      "Revista" => array:5 [
                        "tituloSerie" => "Pathog Dis"
                        "fecha" => "2018"
                        "volumen" => "76"
                        "paginaInicial" => "fty015"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29762733"
                            "web" => "Medline"
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            5 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High prevalence of multidrug resistant <span class="elsevierStyleItalic">S&#46; aureus</span>-CC398 and frequent detection of enterotoxin genes among non-CC398 <span class="elsevierStyleItalic">S</span>&#46; <span class="elsevierStyleItalic">aureus</span> from pig-derived food in Spain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "O&#46;M&#46; Mama"
                            1 => "L&#46; Morales"
                            2 => "L&#46; Ruiz-Ripa"
                            3 => "M&#46; Zarazaga"
                            4 => "C&#46; Torres"
                          ]
                        ]
                      ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijfoodmicro.2020.108510"
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Food Microbiol"
                        "fecha" => "2020"
                        "volumen" => "320"
                        "paginaInicial" => "108510"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31986349"
                            "web" => "Medline"
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              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Population structure of methicillin-susceptible <span class="elsevierStyleItalic">Staphylococcus aureus</span> &#40;MSSA&#41; in Portugal over a 19-year period &#40;1992&#8211;2011&#41;"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Tavares"
                            1 => "N&#46;A&#46; Faria"
                            2 => "H&#46; de Lencastre"
                            3 => "M&#46; Miragaia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10096-013-1972-z"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Clin Microbiol Infect Dis"
                        "fecha" => "2014"
                        "volumen" => "33"
                        "paginaInicial" => "423"
                        "paginaFinal" => "432"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24057140"
                            "web" => "Medline"
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos