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The effectiveness of motor-cognitive dual-task training in reducing risk falls on elderly
Nahdiah Purnamasaria,
Corresponding author
purnamasarinahdiah@gmail.com

Corresponding author.
, Farahdina Bachtiarb, Arnis Puspitha R.c
a Department of Physiotherapy, Faculty of Nursing, Universitas Hasanuddin, Indonesia
b Department of Physiotherapy, Universitas Pembangunan Nasional Veteran Jakarta, Indonesia
c Department of Nursing, Faculty of Nursing, Universitas Hasanuddin, Indonesia
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">According to Indonesian Law No&#46; 13 of 1998 concerning Elderly Welfare&#44; elderly residents are residents aged 60 years or more&#46; Indonesia is a country with an old structure that is characterized by the number of elderly people in 2008&#44; 2009&#44; and 2012 which reached 7&#37; of the total population&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a> Based on the population census in 2010&#44; the number of elderly people in Indonesia is 18&#46;1 million &#40;7&#46;6&#37; of the total population&#41; and have an increasing trend since 2013&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">1&#44;2</span></a> In 2015&#44; the percentage of the elderly population in Indonesia is around 8&#46;5&#37; of the total population and it is estimated that by 2035 the percentage will reach 15&#46;8&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Based on Indonesian Law No&#46; 36 of 2009 concerning health&#44; healthcare efforts for the elderly must be aimed at maintaining a healthy and productive life both socially and economically&#46; Besides&#44; the government is obliged to guarantee the availability of health services and facilitate the elderly to be able to continue to live independently and productively&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">1&#44;2</span></a> In the elderly&#44; the aging process can cause various problems or setbacks in various aspects both physical&#44; biological&#44; psychological&#44; social&#44; spiritual and economic&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a> The aging process will be seen since the age of 45 years and problems arise at the age of 60 years&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">1&#44;3</span></a> Physiological processes in aging make individuals have a higher risk of falling due to the reduced nerve conduction velocity&#44; changed visual acuity&#44; decreased the speed of reaction to tasks&#44; sarcopenia&#44; etc&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">3&#44;4</span></a> Along with these normal changes&#44; the prevalence of mild cognitive impairment &#40;MCI&#41; also increases&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">According to Jamebozorgi et al&#46;&#44; falling is one of the leading causes of death and injury in the elderly population&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">5</span></a> The consequences of severe falls can result in decreased functional independence and quality of life&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">5&#44;6</span></a> The risk of falling increases with age which can be caused by many factors such as a decrease in balance control&#44; decrease in muscle strength&#44; changes in posture&#44; fat levels that accumulate in certain areas&#44; decreased proprioceptive&#44; and visual decline&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">7</span></a> Besides&#44; there is also a decline in cognitive function caused by hippocampal atrophy in the temporal part of the brain&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">8</span></a> Mild cognitive impairment is characterized by a decrease in one or some cognitive function including working memory&#44; attention&#44; and executive function of the brain&#44; but functions related to daily activities are still intact&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">8&#44;9</span></a> Research shows that strengthening executive brain function and improvement cognitive function is still very possible in the elderly&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">9</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Decreased balance and cognitive decline are interrelated and contribute to an increased risk of falling in the elderly&#46; Cognitive input for controlling posture depends on the complexity of a task and the ability of an individual&#39;s postural control system&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">9</span></a> The combination of postural and cognitive control exercises is also called cognitive-motor dual task&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">7&#8211;9</span></a> Park et al&#46; found that exercise generally reduces the risk of falls because it can increase muscle strength and improve balance and gait&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">10</span></a> However&#44; this intervention has little to do with its main effect on functional activities that require static and dynamic balance&#46; The addition of cognitive exercise can strengthen the ability to walk in the elderly who have neurological disorders by improving the ability and speed of turning around&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Increased ability to share attention and perform dual tasks enables the elderly to allocate sufficient attention to balance and gait and improve adaptability to challenging environments such as uneven roads&#44; which significantly reduces the risk of falls in the elderly&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">11</span></a> For healthy elderly&#44; motor tasks performed in the dual-task concept allow better functional capacity index compared to motor tasks performed alone&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">7&#44;8&#44;10</span></a> This is important because many daily activities involve the association of cognitive and motoric components&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">11</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">This study aimed to determine the effect of dual-task training on the risk of falling in the elderly&#44; especially the effect of providing dual-task training on the balance and ability to walk in the elderly&#46; It is expected that this research can be a reference exercise that can improve the independence of the elderly by improving the balance and walking pattern so that it can reduce the risk of falls&#46; Besides&#44; active lifestyle with a certain amount of exercise can maintain overall body and brain function because&#44; in addition to physical training&#44; it can improve the mental health of the elderly&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Method</span><p id="par0035" class="elsevierStylePara elsevierViewall">This study used a pre-experimental design with one group pre-test post-test design&#46; The study was conducted at the Batara Hati Mulia Foundation&#44; one of the integrated community services for the elderly in Gowa Regency&#44; South Sulawesi&#44; Indonesia from March to May 2019&#46; The dual-task motoric-cognitive exercise was carried out three times a week for four weeks&#46; Determination of subjects using several criteria&#58; aged 60&#8211;70 years&#44; no history of falls in the last 6 months&#44; can read writing and have good cognitive function &#40;MMSE<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>18&#41;&#44; no history of disorders&#47;neurological disorders that interfere with balance and walking pattern&#44; no history of impaired cognitive function&#44; and no history of joint injury that interfere with the balance and walking pattern&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The procedure of dual-task training used in this study was as follow&#58; Week 1&#58; walking practice as far as 3 meters&#44; combined with questions about self and subjects&#8217; family&#46; Week 2&#58; walking with a 3-meter diagonal pattern combined with a Stroop test&#59; Week 3&#58; runs a tandem as far as 3 meters combined with counting numbers&#44; mentioning the date&#44; month&#44; day&#44; backward&#59; Week 4&#58; runs tandem with diagonal patterns combined with telling stories about activities since morning&#46; This exercise is done at a dose of 5 repetitions&#44; frequency three times a week with a time of 15<span class="elsevierStyleHsp" style=""></span>min&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Initial data collection was carried out with the Berg Balance Scale measurement pre-test&#44; the Timed-Up-and-Go test&#44; and the Tinetti Balance Assessment Tool test&#46; The risk of falling of the elderly was evaluated after six times of exercise&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Furthermore&#44; the measurement of the final data for the three measuring instruments was carried out again after 12 times of exercises&#46; Data were analyzed using SPSS 23 for Windows program and presented in tables and narration&#46; Statistical tests for normally distributed data use the paired <span class="elsevierStyleItalic">T</span>-test&#44; and for the fall risk data&#44; a hypothesis test is performed using the Friedman and Post hoc Wilcoxon test&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="par0055" class="elsevierStylePara elsevierViewall">The number of respondents&#44; as seen in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> in 14 people with a mean age of 67&#46;86<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;447&#46; Based on gender&#44; it is seen that the majority of respondents are nine women &#40;64&#46;3&#37;&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">The pre-test results in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> show that in the mild risk group the category falls to 3 people &#40;21&#46;4&#37;&#41;&#44; the medium category amounts to 10 people &#40;71&#46;4&#37;&#41;&#44; and the high number is only one person &#40;7&#46;1&#37;&#41;&#46; The results of post-test 1 showed the category of mild fall increased to 10 people &#40;71&#46;4&#37;&#41;&#44; and the moderate category amounted to 4 people &#40;28&#46;4&#37;&#41;&#46; Then in post-test 2&#44; the results showed the category of mild fall increased to 13 people &#40;92&#46;9&#37;&#41;&#44; and the moderate category amounted to 1 person &#40;7&#46;1&#37;&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">The measurement of the risk of falling in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows that there were three respondents in the category of mild risk that did not change the category starting from the measurement of post-test one after six treatments until after giving treatment 12 times&#46; It shows that after giving six treatments there has been an increase in the category of risk of falling&#44; and after 12 treatments still an increase even though still with the same category&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">To see the effect of exercise on the risk of falling in the elderly&#44; the Friedman<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Post hoc Wilcoxon statistical test was used and the Asymp value was obtained&#46; Sig<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#44; which means there is a significant change in the risk of falling after giving 12 exercises with the most changes occurring in post-test 1 that is after 6 treatments &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;011&#41; and no significant changes &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;083&#41; between giving &#8722;6 times up to 12 &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">To support the analysis of falling risk&#44; an evaluation of the dynamic balance of the respondents was also carried out using the Berg Balance Test &#40;BBS&#41; and the Timed-Up-and-Go Test &#40;TUGT&#41; in <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#46; From the results obtained&#44; we can see an increase in the dynamic balance based on the two measuring instruments&#46; The elderly&#39;s balance level based on BBS increased from an average of 49&#46;50<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;74 to 53&#46;71<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;98 after 12 treatments&#46; The results of the TUGT show an increase in speed at completing assignments from an average of 16&#46;19<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;15<span class="elsevierStyleHsp" style=""></span>s to 14&#46;58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;28<span class="elsevierStyleHsp" style=""></span>s at the end of the study&#46; This change was statistically significant for BBS &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; while in TUGT although there was a descriptive increase&#44; it was not statistically significant &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;079&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Discussion</span><p id="par0080" class="elsevierStylePara elsevierViewall">Based on the fall risk analysis table&#44; there was a drastic increase in value from before the treatment was given until after six treatments or post-test 1&#46; This was caused by the adaptation after being given regular training so that there was an increase&#46; In the first treatment and the second treatment&#44; the results obtained did not increase so much because before the treatment was carried out until the first treatment there was a significant increase so that it was different from the second treatment was not too significant as for the increase in the optimization of the first treatment&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Most studies have shown decreased ability to walk in the elderly associated with changes in postural stability&#44; gait speed&#44; rhythm&#44; and stride length&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">4&#44;9&#44;10</span></a> The ability to divide one&#39;s attention between two or more concurrent tasks is an essential aspect of functional movement during ADL&#46; The functional capacity of the elderly is emphasized when performing several tasks simultaneously&#44; because of their limited capacity to perform tasks&#44; either because they need more significant resources of attention&#44; or because of limitations in their information processing capacity from elderly people&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">12</span></a> Besides&#44; some studies have included progressive resistance training with balance training&#44; stepping exercises&#44; and secondary motor exercises&#44; also showing positive effects on cognitive abilities&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">13</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Secondary tasks that require functional responses to verbal and audio cues &#40;for example shifting directions according to oral instructions&#41; or motor tasks that require divided attention &#40;e&#46;g&#46;&#44; throwing a ball while walking&#41; can increase focus and reduce the risk of falling of elderly people&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">12&#44;13</span></a> By providing regular training can increase muscle strength&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">6&#44;10</span></a> The muscle strength of the legs&#44; knees&#44; and hips must be adequate to be able to move the lower limbs to perform functional movements&#46; Muscle strength is directly related to the ability of muscles to resist the force of gravity and other external loads that continuously affect body position or are closely related to balance&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">3&#44;14</span></a> Decreased response to balance can increase the risk of falling so that the addition of progressive resistance training by combining balance training&#44; stepping&#44; and other motor training can prevent the risk of falling&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">6&#44;10&#44;14</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">The results of this study are in line with the research of Tait et al&#46;&#44; showing that simultaneous motor-cognitive training techniques can significantly reduce the risk of falls&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">13</span></a> This is because intensive physical exercise&#44; both in the long and short term&#44; will improve the performance of motor functions and cognitive&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">9&#44;11&#44;15</span></a> Doing physical and motor activities simultaneously can improve both functions&#44; rather than just doing physical exercise or cognitive exercise&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">11&#44;15</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">In dual-task administration&#44; it is not only cognitive that is trained but also motor function&#46; Exercises that are given continuously can train muscle strength&#44; and muscle flexibility so that the muscles in the lower extremities increase&#46; Several factors can reduce the risk of falling&#44; one of which is physical activity that is carried out routinely or regular physical exercise&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">10</span></a> Regular physical exercise can increase blood flow to the brain&#44; help the formation of new brain cells&#44; and prevent disconnection in brain cells&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">6&#44;10&#44;13</span></a> Physical activity can facilitate the metabolism of neurotransmitters&#44; produce trophic factors that stimulate the process of neurogenesis&#44; increase the stimulation of molecular activity&#44; and maintain brain plasticity&#46; This process is essential for inhibiting brain tissue hypertrophy that can cause neuronal degeneration which affects cognitive function&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">15&#44;16</span></a> Combining motor and cognitive activity has a synergistic effect that goes beyond the effects of providing motor and cognitive exercise separately&#46; The synergistic effect of motor training triggers neurophysiological mechanisms that increase neuroplasticity&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">11&#8211;13</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">This exercise is designed to strengthen the motor system and improve the sensory system in old age&#46; When they were first given training&#44; the respondents experienced an imbalance when walking and irregular rhythmic patterns due to the lack of familiarity of respondents doing two activities simultaneously&#46; This is because the brain is still processing to adapt every pattern designed during training&#46; When they have entered the repetition exercise&#44; the respondent starts to get used to the training pattern that is designed although the speed is slightly decreasing the level of focus and balance begins to increase&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">This study does not have a control group&#44; so the effectiveness of this exercise still needs to be tested&#46; Further research is needed by comparing this exercise with other balance exercises&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conclusion</span><p id="par0115" class="elsevierStylePara elsevierViewall">Dual-task exercise is effective in reducing the risk of falling by increasing the dynamic balance of the elderly&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conflict of interest</span><p id="par0120" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
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          "titulo" => "References"
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    "fechaRecibido" => "2019-05-29"
    "fechaAceptado" => "2019-07-15"
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            0 => "Dual-task training"
            1 => "Motoric"
            2 => "Cognitive"
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            4 => "Elderly"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The aging process causes a setback of various aspects of the body that makes the elderly vulnerable to fall&#46; The dual-task exercise amalgamates physical and cognitive training together and induces synergistic effects&#46; This study aims to determine the effect of dual-task training on the risk of falls on elderly&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The method used was pre-experimental design with 3 times a week intervention for 4 weeks&#46; Before and after treatment&#44; respondents measured the level of balance and risk of falling using the Berg Balance Scale &#40;BBS&#41;&#44; Timed-Up-and-Go test &#40;TUGT&#41;&#44; and Tinetti Balance Assessment Tool&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The results showed an increase in the balance after 12 times of exercises&#46; The risk of falls seems to decline after 12 treatments&#44; and the highest reduction occurred after the first 6 treatments&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">It can be concluded that dual-task motor-cognitive training is significantly influential in reducing risk falls on elderly&#46;</p></span>"
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                  \t\t\t\t">5&#46;447&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Male&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">35&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Pre-test&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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Original language: English
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