array:22 [ "pii" => "S0213616324000107" "issn" => "02136163" "doi" => "10.1016/j.ejpsy.2024.100260" "estado" => "S300" "fechaPublicacion" => "2024-07-01" "aid" => "100260" "copyright" => "Sociedad Española de Psiquiatría y Salud Mental" "copyrightAnyo" => "2024" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Eur J Psychiatry. 2024;38:" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "itemAnterior" => array:18 [ "pii" => "S0213616324000053" "issn" => "02136163" "doi" => "10.1016/j.ejpsy.2024.100254" "estado" => "S300" "fechaPublicacion" => "2024-07-01" "aid" => "100254" "copyright" => "The Authors" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Eur J Psychiatry. 2024;38:" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Short communication</span>" "titulo" => "Gender differences in the therapeutic response to lifestyle improvement-based interventions for treatment-resistant depression" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0001" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2132 "Ancho" => 3000 "Tamanyo" => 183304 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0001" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Estimated Marginal Means of BDI-II.</p> <p id="spara002" class="elsevierStyleSimplePara elsevierViewall">Note. * <span class="elsevierStyleItalic">p</span> < 0.05 between men and women. Statistics used: Repeated measures ANOVA adjusted by age and intervention group.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Alejandra Aguilar-Latorre, Margalida Gili, Capilla Navarro-Guzmán, Aurora Garcia, Aina M. Yáñez, Mauro Garcia-Toro" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Alejandra" "apellidos" => "Aguilar-Latorre" ] 1 => array:2 [ "nombre" => "Margalida" "apellidos" => "Gili" ] 2 => array:2 [ "nombre" => "Capilla" "apellidos" => "Navarro-Guzmán" ] 3 => array:2 [ "nombre" => "Aurora" "apellidos" => "Garcia" ] 4 => array:2 [ "nombre" => "Aina M." "apellidos" => "Yáñez" ] 5 => array:2 [ "nombre" => "Mauro" "apellidos" => "Garcia-Toro" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213616324000053?idApp=UINPBA00004N" "url" => "/02136163/0000003800000003/v1_202407151101/S0213616324000053/v1_202407151101/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letters to the editor</span>" "titulo" => "The new long-acting injectable for maintenance treatment of schizophrenia: What is the clinical value of aripiprazole 2-month ready-to-use 960 mg?" "tieneTextoCompleto" => true "saludo" => "To the Editor:" "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Cecilio Álamo, Ana Catalán, David Fraguas, Francisco Gotor, Javier Labad, Carlos Parro-Torres, Víctor Pérez, Pilar Sierra" "autores" => array:8 [ 0 => array:4 [ "nombre" => "Cecilio" "apellidos" => "Álamo" "email" => array:1 [ 0 => "Cecilio.alamo@uah.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0001" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0001" ] ] ] 1 => array:3 [ "nombre" => "Ana" "apellidos" => "Catalán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0002" ] ] ] 2 => array:3 [ "nombre" => "David" "apellidos" => "Fraguas" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0003" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0004" ] ] ] 3 => array:3 [ "nombre" => "Francisco" "apellidos" => "Gotor" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Javier" "apellidos" => "Labad" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0006" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "aff0007" ] ] ] 5 => array:3 [ "nombre" => "Carlos" "apellidos" => "Parro-Torres" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">h</span>" "identificador" => "aff0008" ] ] ] 6 => array:3 [ "nombre" => "Víctor" "apellidos" => "Pérez" "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">i</span>" "identificador" => "aff0009" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">j</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">k</span>" "identificador" => "aff0011" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">l</span>" "identificador" => "aff0012" ] ] ] 7 => array:3 [ "nombre" => "Pilar" "apellidos" => "Sierra" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">m</span>" "identificador" => "aff0013" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">n</span>" "identificador" => "aff0014" ] ] ] ] "afiliaciones" => array:14 [ 0 => array:3 [ "entidad" => "Department of Biomedical Sciences (Pharmacology Area), Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0001" ] 1 => array:3 [ "entidad" => "Mental Health Department, Basurto University Hospital. Biocruces Bizkaia Health Research Institute, Department of Neuroscience, Campus de Leioa, University of the Basque Country, Barakaldo, Bizkaia, Spain" "etiqueta" => "b" "identificador" => "aff0002" ] 2 => array:3 [ "entidad" => "Institute of Psychiatry and Mental Health, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), School of Medicine, Universidad Complutense, Madrid, Spain" "etiqueta" => "c" "identificador" => "aff0003" ] 3 => array:3 [ "entidad" => "Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain" "etiqueta" => "d" "identificador" => "aff0004" ] 4 => array:3 [ "entidad" => "Psychiatry Department, School of Medicine, University Hospital Virgen del Rocio, Seville, Spain" "etiqueta" => "e" "identificador" => "aff0005" ] 5 => array:3 [ "entidad" => "Department of Mental Health and Addictions, Consorci Sanitari del Maresme, Mataró, Spain" "etiqueta" => "f" "identificador" => "aff0006" ] 6 => array:3 [ "entidad" => "Institut d'Investigació i Innovació Sanitària Parc Tauli (I3PT), CIBERSAM, Sabadell, Spain" "etiqueta" => "g" "identificador" => "aff0007" ] 7 => array:3 [ "entidad" => "Institute of Psychiatry and Mental Health, Gregorio Marañón University General Hospital, Madrid, Spain" "etiqueta" => "h" "identificador" => "aff0008" ] 8 => array:3 [ "entidad" => "Department of Psychiatry and Forensic Medicine, Faculty of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain" "etiqueta" => "i" "identificador" => "aff0009" ] 9 => array:3 [ "entidad" => "Mental Health Research Group, Hospital del Mar Research Institute, Barcelona, Spain" "etiqueta" => "j" "identificador" => "aff0010" ] 10 => array:3 [ "entidad" => "Centre for Biomedical Research in Mental Health Network (CIBERSAM), Madrid, Spain" "etiqueta" => "k" "identificador" => "aff0011" ] 11 => array:3 [ "entidad" => "Institute of Neuropsychiatry and Addictions, Hospital del Mar, Barcelona, Spain" "etiqueta" => "l" "identificador" => "aff0012" ] 12 => array:3 [ "entidad" => "Department of Psychiatry and Clinical Psychology, La Fe University and Polytechnic Hospital, Valencia, Spain" "etiqueta" => "m" "identificador" => "aff0013" ] 13 => array:3 [ "entidad" => "Department of Medicine, University of Valencia, Valencia, Spain" "etiqueta" => "n" "identificador" => "aff0014" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0001" "etiqueta" => "⁎" "correspondencia" => "Corresponding author at: Department of Biomedical Sciences (Pharmacology Area), Faculty of Medicine and Health Sciences, University of Alcalá, Crta. de Madrid-Barcelona, Km. 33,600, 28871 Alcalá de Henares, Madrid, Spain." ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0002" class="elsevierStylePara elsevierViewall">At present, achieving functionality has become the therapeutic goal in most patients with schizophrenia, and several maintenance treatment options are available.<a class="elsevierStyleCrossRef" href="#bib0001"><span class="elsevierStyleSup">1</span></a> However, there are unmet needs that must be tackled, including poor treatment adherence or relapses.<a class="elsevierStyleCrossRef" href="#bib0002"><span class="elsevierStyleSup">2</span></a> Aripiprazole is a well-known molecule that has been effectively used in the treatment of schizophrenia since 2004.<a class="elsevierStyleCrossRef" href="#bib0002"><span class="elsevierStyleSup">2</span></a> Various oral presentations of the drug, together with 400 mg aripiprazole once-monthly (AOM) and 7.5 mg IM injectable formulations, have been available for some time. The results of the PK profile of a new, longer-acting injectable of 960 mg aripiprazole in a ready-to-use (RTU) formulation (Ari2MRTU960) for administration every 2 months (ClinicalTrials.gov identifier: NCT04030143) have recently been published.<a class="elsevierStyleCrossRef" href="#bib0003"><span class="elsevierStyleSup">3</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0004"><span class="elsevierStyleSup">4</span></a> As clinicians with experience in the management of people with schizophrenia, we have assessed the data of this pharmacokinetic (PK) bridging study and their applicability, in order to identify the potential benefits of this new formulation and aspects that should be addressed in the short-medium term. To this end, we completed a 40-item questionnaire as individual pre-work, and the aggregated answers were subsequently discussed in a scientific meeting.</p><p id="para0003" class="elsevierStylePara elsevierViewall">We believe that the basis of this pharmacokinetic bridging study, as well as several issues related to its design and outcomes, should be clarified to facilitate interpretation by clinicians. Firstly, a phase 3 study may be not required by regulatory agencies, as Ari2MRTU960 is the same molecule as AOM in a different formulation, and the latter has already undergone multiple phase 3 trials and real-life studies and shown good efficacy, effectiveness, and safety results in the post-marketing period.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">5</span></a> The aim, therefore, of the above-mentioned PK study was to compare the PK, safety, and tolerability of the new Ari2MRTU960 formulation versus AOM. Once-monthly IM aripiprazole has already shown consistent drug plasma concentrations above the reported threshold (Cmin ≥ 95 ng/mL) which are in turn associated with an almost 4.5-fold reduction in relapses.<a class="elsevierStyleCrossRef" href="#bib0004"><span class="elsevierStyleSup">4</span></a> With its comparable PK profile, the 2-monthly formulation was expected to do the same, so efficacy was also assessed as a secondary objective within the study. The ethnic composition of the study was different to that of our own setting in Spain, but this was not expected to necessarily interfere with the applicability of Ari2MRTU960 in clinical practice, as the study shows a PK, tolerability, safety, and efficacy profile consistent with that of AOM<a class="elsevierStyleCrossRef" href="#bib0003"><span class="elsevierStyleSup">3</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0004"><span class="elsevierStyleSup">4</span></a> (<a class="elsevierStyleCrossRef" href="#tbl0001">Table 1</a>). Secondary clinical outcomes assessed in the study showed that patients receiving Ari2MRTU960 remained clinically stable throughout the 32 weeks, and the experience and previous data supporting the clinical value of the molecule itself foster confidence in this formulation.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">5</span></a></p><elsevierMultimedia ident="tbl0001"></elsevierMultimedia><p id="para0004" class="elsevierStylePara elsevierViewall">We therefore believe that Ari2MRTU960 may provide relevant additional benefits in the landscape of maintenance schizophrenia management. It is the only extended-release D2 partial agonist antipsychotic to demonstrate sustained efficacy for 2 months with minimal fluctuation of drug plasma concentration levels and a comparable safety and efficacy profile to AOM.<a class="elsevierStyleCrossRef" href="#bib0003"><span class="elsevierStyleSup">3</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0004"><span class="elsevierStyleSup">4</span></a> We presume this will positively impact on treatment adherence, as has previously occurred with other antipsychotic drugs, because a lower administration frequency is more convenient for patients, and improved therapeutic adherence should in turn help prevent relapses. The reduced burden of such a treatment schedule may also offer potential advantages for healthcare professionals. A 2-month frequency may also be optimal in terms of patient visits because the drug administration and follow-up visit can occur at the same time, achieving regular follow-up while avoiding additional visits for the patient. Furthermore, since many patients might already be receiving treatment with the previous aripiprazole formulations, several treatment initiation options could facilitate initiation of Ari2MRTU960. This would optimize the therapeutic approach by permitting individualization based on each patient´s case or circumstances.</p><p id="para0005" class="elsevierStylePara elsevierViewall">In conclusion, Ari2MRTU960 may be an advance towards regaining functionality as a therapeutic objective with respect to the previously available options: patient stability can be more easily maintained, so any patient with schizophrenia who is stable and tolerates aripiprazole well can benefit from this new formulation. Persistence and therapeutic adherence studies with Ari2MRTU960 should be conducted in the near future.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2024-02-21" "fechaAceptado" => "2024-03-15" "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "tbl0001" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0001" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spara002" class="elsevierStyleSimplePara elsevierViewall">AE, adverse events; AUC, area under the curve; SD, standard deviation.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><a name="en0001"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0002"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">Ari2MRTU960</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0003"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">AOM400</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><a name="en0004"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="top">Molecule \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0005"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">aripiprazole \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0006"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">aripiprazole \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0007"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="top">Injection site \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0008"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">gluteal \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0009"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">gluteal or deltoid muscle \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0010"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="top">Plasma concentration on the last day of the dosing interval, ng/mL, mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0011"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">C<span class="elsevierStyleInf">56</span> = 250 (128) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0012"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">C<span class="elsevierStyleInf">28</span> = 257 (162) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0013"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="top">C<span class="elsevierStyleInf">max</span>, ng/mL, mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0014"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">342 (157) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0015"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">344 (212) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0016"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="top">AUC<span class="elsevierStyleInf">0–56</span>, day⋅ng/mL \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0017"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">14,700 (7460) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0018"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0019"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="top">AUC<span class="elsevierStyleInf">0–28</span>, day⋅ng/mL \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0020"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">7840 (5170) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0021"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">7190 (3470) Eighth dose \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0022"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="top">Discontinuation rate due to AE in the study NCT04030143 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0023"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">3.3 % (<span class="elsevierStyleItalic">n</span> = 3) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0024"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">7.5 % (<span class="elsevierStyleItalic">n</span> = 7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0025"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="top">AE during study NCT04030143 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0026"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">67.4 % (<span class="elsevierStyleItalic">n</span> = 62) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0027"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">64.5 % (<span class="elsevierStyleItalic">n</span> = 60) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3594641.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Comparison between 2-month ready-to-use aripiprazole 960 mg (Ari2MRTU960) and aripiprazole once-monthly 400 mg (AOM400).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec1" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0001" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patient functioning, life engagement, and treatment goals in schizophrenia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.U. 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Journal Information
Vol. 38. Issue 3.
(July - September 2024)
Vol. 38. Issue 3.
(July - September 2024)
Letters to the editor
The new long-acting injectable for maintenance treatment of schizophrenia: What is the clinical value of aripiprazole 2-month ready-to-use 960 mg?
Visits
86
Cecilio Álamoa,
, Ana Catalánb, David Fraguasc,d, Francisco Gotore, Javier Labadf,g, Carlos Parro-Torresh, Víctor Pérezi,j,k,l, Pilar Sierram,n
Corresponding author
Cecilio.alamo@uah.es
Corresponding author at: Department of Biomedical Sciences (Pharmacology Area), Faculty of Medicine and Health Sciences, University of Alcalá, Crta. de Madrid-Barcelona, Km. 33,600, 28871 Alcalá de Henares, Madrid, Spain.
Corresponding author at: Department of Biomedical Sciences (Pharmacology Area), Faculty of Medicine and Health Sciences, University of Alcalá, Crta. de Madrid-Barcelona, Km. 33,600, 28871 Alcalá de Henares, Madrid, Spain.
a Department of Biomedical Sciences (Pharmacology Area), Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain
b Mental Health Department, Basurto University Hospital. Biocruces Bizkaia Health Research Institute, Department of Neuroscience, Campus de Leioa, University of the Basque Country, Barakaldo, Bizkaia, Spain
c Institute of Psychiatry and Mental Health, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), School of Medicine, Universidad Complutense, Madrid, Spain
d Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain
e Psychiatry Department, School of Medicine, University Hospital Virgen del Rocio, Seville, Spain
f Department of Mental Health and Addictions, Consorci Sanitari del Maresme, Mataró, Spain
g Institut d'Investigació i Innovació Sanitària Parc Tauli (I3PT), CIBERSAM, Sabadell, Spain
h Institute of Psychiatry and Mental Health, Gregorio Marañón University General Hospital, Madrid, Spain
i Department of Psychiatry and Forensic Medicine, Faculty of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain
j Mental Health Research Group, Hospital del Mar Research Institute, Barcelona, Spain
k Centre for Biomedical Research in Mental Health Network (CIBERSAM), Madrid, Spain
l Institute of Neuropsychiatry and Addictions, Hospital del Mar, Barcelona, Spain
m Department of Psychiatry and Clinical Psychology, La Fe University and Polytechnic Hospital, Valencia, Spain
n Department of Medicine, University of Valencia, Valencia, Spain
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