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Vol. 35. Issue 1.
Pages 33-40 (January - March 2021)
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Vol. 35. Issue 1.
Pages 33-40 (January - March 2021)
Original article
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Trends in the cost and utilization of psychotropic medicines for major psychiatric disorders in Bulgaria from 2013 to 2017
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1397
K. Tachkova, D. Ignatovab, K. Mitova, M. Kamushevaa,
Corresponding author
maria.kamusheva@yahoo.com
mkamusheva@pharmfac.mu-sofia.bg

Corresponding author at: Department of Organization and Economics of Pharmacy, Faculty of Pharmacy, Medical University, Sofia, 2-Dunav Str., Sofia, 1000, Bulgaria.
, G. Petrovaa
a Department of Organization and Economics of Pharmacy, Faculty of Pharmacy, Medical University, Sofia, Bulgaria
b Department of Psychiatry and Medical Psychology, Faculty of Medicine, Medical University, Sofia, Bulgaria
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Table 1. Structure of the reimbursed mental disorders.
Table 2. Reimbursed pharmacotherapy cost.
Table 3. Utilisation of therapeutic groups in DDD/1000inh/day.
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Abstract
Background and objectives

Major psychiatric disorders require prolonged use of psychotropic medications and pose a significant economic burden. The purpose of the study is to examine the trend in outpatient utilization and public expenditures for reimbursed psychotropic medicines for major psychiatric disorders in Bulgaria from 2013 to 2017.

Methods

Data on the cost and utilization of reimbursed psychotropic medications for schizophrenia and affective disorders are collected retrospectively from the National Health Insurance Fund (NHIF) for the period 2013–2017. The diagnostic groups included in the analysis are based on ICD codes from F20.0 to F33.4. Psychotropic drugs are systematized according to ATC code and INN. Reimbursed pharmacotherapy costs are analyzed per year and diagnosis. Drug utilization is calculated for each year in defined daily doses per 1000 inhabitants per day (DDD/1000inh/day).

Results

The number of patients decreased from 62 500 to 54 000, or from 834 per 1 00 000 in 2013 to 733 per 1 00 000 in 2017, or with a 3.5% decrease per year. The highest number (28,674 in 2013; 26,235 in 2017) and with the highest relative share (46%–49%) were patients with paranoid schizophrenia. The reimbursed pharmacotherapy cost showed a decreasing tendency from 35 to 31 million BGN in 2013 and 2017, respectively. In total 31 INN of medicines for psychotic disorders therapy were reimbursed. The utilization of all ATC groups is decreasing from 28.04 to 17.38 DDD/1000inh/day.

Conclusions

The number of reimbursed patients with major psychiatric disorders, as well as the cost of pharmacotherapy and utilization of psychotropic medicines decreased in the period 2013–2017.

Keywords:
Psychiatric disorders
Medicines utilization
Reimbursed cost
DDD/1000inh/day
Full Text
Introduction

Major psychiatric disorders typically require prolonged use of psychotropic medications and pose a significant economic burden on societies.1 Schizophrenia and affective disorders are two of the major groups of mental disorders that have in common a chronic course, episodic nature, and remissions with varying degree of symptoms and disability.2,3 Historically dichotomized by Kraepelin, schizophrenia and affective disorders are differentiated most commonly by the prevalence of thought disturbances, disturbances of volition and first-rank symptoms in schizophrenia and predominance of mood symptoms in affective disorders.4 While depression is renowned to be the major cause of years lived in disability (YLD), the acute schizophrenic episode is the condition that has the highest disability weight (to be most closely to death) as measured by the Global Burden of Diseases.5,6

The discovery of the first-generation antipsychotics (typical antipsychotics) in the 1940s, followed by the discovery and introduction of atypical antipsychotics and antidepressants in the 1960s and 1970s has led to the possibility of deinstitutionalization of the severely mentally ill and treatment in the community.7,8 Since then, there has been a proliferation of psychotropic medications.9 Access to community-based mental health services and the affordability of psychotropic medication are now of utmost importance in the successful treatment of the mentally ill.10

Several pharmacoepidemiological studies explore the trends in the prescription and administration of psychotropic drugs.11 Report from the European Commission recommends monitoring and comparing the medicines available in the European Union, their prices, utilization, expenditure, and licensed clinical properties, as well as to compare national data with similar structure and content by using the defined daily doses and Anatomical Therapeutic Chemical classification (ATC)of medicines.12 The defined daily doses per 1000 inhabitants per day (DDD/1000inh/day) are widely used as a comparative measure of medicines utilization in different health care settings and across diseases.13

While expenditures for mental health in some countries increase steadily,14 in others they remain low.15 Underfunding of mental healthcare on behalf of financial institutions could be to the detriment of patients and their caregivers.16,17 Bulgaria lacks nationwide surveys on the pharmacotherapy cost and utilization of medicines for psychiatric disorders.

The purpose of the study is to analyze the trends in the public expenditures and utilization of medicines for two major psychiatric disorders – schizophrenia and affective disorders in outpatient settings in Bulgaria from 2013 to 2017.

Material and methods

Publicly available data from the National Health Insurance Fund (NHIF) was used to gather information on the number of reimbursed patients and medications used for major psychiatric disorders in outpatient settings for the period 2013–2017. The systematization of patients was based on the International Classification of Diseases (ICD) codes - diagnoses from F20.0 to F33.4 were included in the analysis. Absolute number, relative share, and changes per year and diagnosis were analyzed. All prescribed psychotropic medicines were systematized by ATC code and International Non-proprietary Name (INN). The reimbursed cost is analyzed per year and diagnosis. The cost is presented in the national currency (BGN) at the exchange rate of 1 BGN = 0.51 Euro. Medicines utilization was calculated for every year per ATC code and INN in defined daily doses per 1000 inhabitants per day (DDD/1000inh/day) by using the following formula:

ResultsReimbursed patients with psychiatric disorders in Bulgaria

The number of reimbursed patients with the selected psychiatric disorders decreased from 62 500 to 54 000 individuals with a tendency of linear decrease with approximately 2200 people per year (3.5%). The number of reimbursed patients with the investigated mental disorders was 834 per 100 000 of the population in 2013 decreasing to 733 per 100 000 in 2017. The tendency is outlined in Fig. 1.

Figure 1.

Changes in the total number of reimbursed patients with psychotic disorders during 2013–2017.

(0.07MB).

The highest number of reimbursed patients (28 674 in 2013; 26 235 in 2017), with the highest relative share (46%–49%, respectively), have paranoid schizophrenia. It is followed by major depressive disorder, a moderate episode that accounts for nearly 25% of the reimbursed patients. Depressive disorders together from F33.0 to F33.4 account for nearly 35% of all reimbursed patients with the selected mental disorders. Patients with bipolar disorders (F31.0 to F31.7) accounting for near 17.5% of all reimbursed patients in the investigated group. Data are summarized in Table 1.

Table 1.

Structure of the reimbursed mental disorders.

ICD code  Diagnosis  2013 (n)  2013 (%)  2014 (n)  2014 (%)  2015 (n)  2015 (%)  2016 (n)  2016 (%)  2017 (n)  2017 (%) 
F20.0  Paranoid schizophrenia  28 674  45.93  28 306  46.48  27 530  47.30  26 753  48.20  26 235  48.64 
F20.1  Disorganized schizophrenia  183  0.29  186  0.31  190  0.33  194  0.35  186  0.34 
F20.5  Residual schizophrenia  332  0.53  299  0.49  283  0.49  268  0.48  248  0.46 
F20.6  Simple schizophrenia  464  0.74  454  0.75  428  0.73  401  0.72  387  0.72 
F30.0  Hypomania  114  0.18  103  0.17  98  0.17  92  0.17  99  0.18 
F30.1  Manic episode without psychotic symptoms  46  0.07  43  0.07  39  0.07  35  0.06  41  0.08 
F31.0  Bipolar disorder, current episode hypomanic  1722  2.76  1588  2.61  1515  2.60  1442  2.60  1425  2.64 
F31.1  Bipolar disorder, current episode manic without psychotic features  1495  2.39  1409  2.31  1331  2.29  1252  2.26  1276  2.37 
F31.2  Bipolar disorder, current episode manic severe with psychotic features  612  0.98  580  0.95  550  0.94  520  0.94  523  0.97 
F31.3  Bipolar disorder, current episode depressed. mild or moderate severity  3170  5.08  3069  5.04  2873  4.94  2676  4.82  2551  4.73 
F31.4  Bipolar disorder, current episode depressed, severe, without psychotic features  399  0.64  377  0.62  348  0.60  320  0.58  296  0.55 
F31.5  Bipolar disorder, current episode depressed, severe, with psychotic features  142  0.23  122  0.20  104  0.18  86  0.15  75  0.14 
F31.6  Bipolar disorder, current episode mixed  2058  3.30  2077  3.41  1911  3.28  1745  3.14  1577  2.92 
F31.7  Bipolar disorder, currently in remission  1413  2.26  1381  2.27  1393  2.39  1406  2.53  1529  2.83 
F33.0  Major depressive disorder, recurrent, mild  3624  5.80  3421  5.62  3080  5.29  2739  4.93  2581  4.78 
F33.1  Major depressive disorder, recurrent, moderate  15 368  24.61  15 042  24.70  14 315  24.59  13 588  24.48  13 094  24.27 
F33.2  Major depressive disorder, recurrent severe without psychotic features  843  1.35  778  1.28  739  1.27  701  1.26  674  1.25 
F33.3  Major depressive disorder, recurrent, severe with psychotic symptoms  130  0.21  113  0.19  113  0.19  114  0.20  103  0.19 
F33.4  Major depressive disorder, recurrent, in remission  1647  2.64  1558  2.56  1368  2.35  1179  2.12  1044  1.94 
Cost analysis

For the observed period, the reimbursed cost of medicines also showed a decreasing tendency from 35 to 31 million BGN in 2013 and 2017, respectively. The cost of paranoid schizophrenia therapy is the leading one in terms of value and relative share. In 2013 it accounted for 29 million and decreased to 27 million in 2017, but its relative share as part of all expenditures showed an increase from 84% to 88%, respectively. The reimbursed cost of pharmacotherapy for bipolar disorders and depression accounted for nearly 8% for each disorder. The cost of pharmacotherapy for other disorders accounted for 5%–6% depending on the year of observation. Data are summarized in Table 2.

Table 2.

Reimbursed pharmacotherapy cost.

ICD code  Diagnosis  2013  2013 (%)  2014  2014 (%)  2015  2015 (%)  2016  2016 (%)  2017  2017 (%) 
    BGN    BGN    BGN    BGN    BGN   
F20.0  Paranoid schizophrenia  29 38 2264  84.00  28 20 1170  85.36  27 80 9805  85.96  27 41 8439  86.57  27 21 8776  87.54 
F20.1  Disorganized schizophrenia  1 67 167  0.48  1 54 635  0.47  1 68 503  0.52  1 82 371  0.58  1 86 461  0.60 
F20.5  Residual schizophrenia  2 00 756  0.57  2 06 714  0.63  2 22 755  0.69  2 38 795  0.75  2 21 011  0.71 
F20.6  Simple schizophrenia  2 91 118  0.83  2 77 347  0.84  2 74 972  0.85  2 72 597  0.86  2 51 605  0.81 
F30.0  Hypomania  20 622  0.06  14 698  0.04  14 714  0.05  14 730  0.05  16 268  0.05 
F30.1  Manic episode without psychotic sympt.  15 652  0.04  15 828  0.05  12 124  0.04  8419  0.03  10 975  0.04 
F31.0  Bipolar disorder, current episode hypomanic  8 21 163  2.35  6 67 345  2.02  5 76 579  1.78  4 85 814  1.53  4 21 872  1.36 
F31.1  Bipolar disorder, current episode manic without psychotic features  7 16 076  2.05  6 02 750  1.82  5 16 819  1.60  4 30 889  1.36  3 92 747  1.26 
F31.2  Bipolar disorder, current episode manic severe with psychotic features  3 26 119  0.93  2 62 519  0.79  2 31 831  0.72  2 01 143  0.64  1 71 126  0.55 
F31.3  Bipolar disorder, current episode depressed, mild or moderate severity  5 65 718  1.62  3 93 793  1.19  3 58 775  1.11  3 23 757  1.02  2 87 276  0.92 
F31.4  Bipolar disorder, current episode depressed, severe, without psychosis  76 131  0.22  51 961  0.16  46 987  0.15  42 014  0.13  36 582  0.12 
F31.5  Bipolar disorder, current episode depressed, severe, with psychotic features  36 447  0.10  20 730  0.06  17 366  0.05  14 003  0.04  11 448  0.04 
F31.6  Bipolar disorder, current episode mixed  5 15 450  1.47  4 14 207  1.25  3 61 566  1.12  3 08 925  0.98  2 89 595  0.93 
F31.7  Bipolar disorder, currently in remission  3 58 891  1.03  2 74 667  0.83  3 15 776  0.98  3 56 884  1.13  3 82 745  1.23 
F33.0  Major depressive disorder, recurrent, mild  2 32 939  0.67  2 29 132  0.69  2 07 792  0.64  1 86 452  0.59  1 62 986  0.52 
F33.1  Major depressive disorder, moderate  10 98 423  3.14  11 04 318  3.34  10 74 988  3.32  10 45 659  3.30  9 17 965  2.95 
F33.2  Major depressive disorder, recurrent severe without psychotic features  59 132  0.17  57 409  0.17  60 854  0.19  64 299  0.20  53 695  0.17 
F33.3  Major depressive disorder, recurrent, severe with psychotic symptoms  9593  0.03  8233  0.02  9651  0.03  11 069  0.03  9406  0.03 
F33.4  Major depressive disorder, in remission  83 610  0.24  78 714  0.24  71 495  0.22  64 276  0.20  51 681  0.17 
  Total (BGN)  3 49 77 265  100  3 30 36 167  100  3 23 53 351  100  3 16 70 535  100  3 10 94 219  100 
Medicines utilization analysis

In total 31 INN of medicines, recommended for treatment of the selected psychiatric disorders, were reimbursed during the period 2013–2017. Four INNs were reimbursed only during the first 3 years of the observed period (2013–2016), namely flupentixol, alprazolam, fluoxetine, and citalopram. The utilization of all ATC groups together is decreasing from 28.04 to 17.38 DDD/1000inh/day during 2013–2017 (Table 3).

Table 3.

Utilisation of therapeutic groups in DDD/1000inh/day.

ATC group  Therapeutic group  2013  2014  2015  2016  2017 
N04BD  Monoaminooxidase inhibitors  0.532  0.535  0.519  0.484  0.419 
N05AB  Phenothiazines  0.367  0.452  0.187  0.014  0.012 
N05AD  Butirophenones  0.149  0.172  0.187  0.021  0.206 
N05AE  Derivatives of indol  0.097  0.093  0.080  0.081  0.078 
N05AF  Derivatives of thioxanten  0.225  0.208  0.200  0.097  0.112 
N05AH  Diazepines. oxazapines and thiazapines  15.780  13.393  11.729  10.296  9.957 
N05AL  Benzamides  0.382  0.400  1.044  1.038  0.799 
N05AX  Other antipsychotics  8.779  6.251  4.708  2.377  4.730 
N05BA  Benzodiazepines  0.000  0.000  0.000     
N05BB  Derivatives of diphenilmetane  0.003  0.003  0.004  0.004  0.004 
N06AB  Selective serotonin reuptake inhibitors  1.173  1.023  0.963  0.729  0.761 
N06AX  Other antidepressants  0.554  0.498  0.467  0.399  0.301 
  Total  28.039  23.028  20.086  15.542  17.380 

Within the therapeutic groups, a lot of variations are observed. Diazepines (N05AH), comprising of olanzapine, clozapine, quetiapine, and asenapine were the most widely prescribed with their utilization decreasing from 15.7 to 10 DDD/1000inh/day during 2013–2018, respectively. The second therapeutic group in utilization is that of other antipsychotics which include risperidone, aripiprazole, and paliperidone. It also saw a steady decrease in prescribed doses from 8.77 to 3.58 DDD/1000inh/day during 2013−2018. The same tendency was also observed for selective serotonin reuptake inhibitors (fluoxetine, citalopram, paroxetine, sertraline, fluvoxamine, and escitalopram) with a decrease in utilization from 1.17 to 0.69 DDD71000inh/day for the period.

In terms of INNs, the highest was the utilization of olanzapine, however, it still decreased from 13.39 to 8.75 DDD/1000inh./day during 2013–2018 years. The second product was risperidone with an extremely sharp decrease in utilization from 7.7 to 0.28 DDD/1000inh/day. Only the utilization of aripiprazole saw an increase in prescribed doses from 0.692 to 2.65 DDD/1000inh/day. The utilization of olanzapine and risperidone exhibited a sharper decrease during the observed period. All other INNs have nearly performed at a stable and low utilization rate as shown in Fig. 2.

Figure 2.

Utilization in DDD/1000inh/day for selected chemical subgroup.

(0.18MB).
Discussion

The results of the study present an upsetting tendency of a decrease in the reimbursable expenditures for outpatient psychopharmacotherapy of the major types of psychiatric disorders in Bulgaria during 2013–2017. Zuvekas reported that due to rapid innovation, spending on psychotropic drugs almost tripled from $5.9 million to $14.7 million for the period 1996−2001.18 Moreover, retail sales for antidepressants grew faster than retail sales for any other therapeutic class from 2000 to 2001 in the UK.19 The use of psychotropic drugs increased with 4.7% from 1997 to 2000 for youths 17 years and younger in the USA.20 While in the majority of countries mental health expenditures increase18,20–22 and international studies have so far reported increases in health care spending with almost 58%,13 our study shows that the ambulatory cost had decreased in the 6-year observation period. This could be potentially detrimental to the care for severely mentally ill patients as recent Bulgarian studies report that the societal costs are five-to-six times higher than the healthcare cost23 and out-of-pocket costs of families are significant.17

Health care in Bulgaria is financed from obligatory and voluntary health insurance contributions and out-of-pocket payments.24 The patients’ access to reimbursed medicines paid by the public fund (National Health Insurance Fund) is ensured through a clearly defined procedure in the Law on the Medicinal Products in Human Medicine/2007, Health Law/2005 and Health Insurance Law/1999 and in the corresponding regulations. The first step of ensuring medicinal product access to the national market is obtaining the marketing authorization by the responsible drug agency following a particular procedure described in the Law on the Medicinal Products in Human Medicine/2007 or Regulation 726/2004. The procedure for price formation of every medicinal product is obligatory for the purposes of entering the national market. National Council on prices and reimbursement of medicinal products (MPs) (the Council) regulates the ceiling price of prescription medicinal products and registers the prices of over-the-counter drugs following the available regulations. The reimbursement process involves presenting evidences on efficacy, safety and pharmacoeconomic criteria. In a case of new INN, the Council should make an appraisal of Health Technology Assessment Report (HTA-report), submitted by MAH. Then the MAH should negotiate discounts with the NHIF and apply for pricing and reimbursement listing into the PDL. All procedures and deadlines are in accordance with Transparency Directive of EU. Marketing authorization holders are obliged to present evidence about the therapeutic effectiveness of medicinal products in real-life settings every three years.25 The drugs and diagnoses that are reimbursed for citizens with health insurance are included in a National Positive Drug List. The inclusion, as it is mentioned above, is based on the required legislative criteria of efficacy, safety data, and pharmacoeconomic considerations regarding cost-effectiveness and budget impact of the assessed therapy.26 Reimbursement rate is defined on the basis of pre-defined legislative criteria. It could be partial (up to 50% or 75%) or full (100%) as the reimbursement rate for inpatient treatment of obligatory health insured patients with psychotropic medicines is 100% and for outpatient – 50% or 100%.27

While the psychiatric inpatient care in Bulgaria is financed by the government regardless of patients’ health insurance status, outpatient psychiatric care is funded by the National Health Insurance Fund (NHIF). Only citizens with health insurance are privileged to take reimbursed medications, therefore the increased rates of unemployment and poor socio-economic status of the families of the severely mentally ill pose a high risk for the patients to remain without the health insurance and thus unable to take reimbursed medications.28,29 Another bureaucratic complication is that the diagnostic category schizoaffective disorders (F25 according to ICD-10) in Bulgaria is not included in the Positive Drug List, and therefore psychotropic medication prescribed for this diagnosis cannot be reimbursed by the NHIF. This could also be the reason for the overrepresentation of the diagnosis of paranoid schizophrenia, as seen in our results.

The prevalence of mental disorders and hospitalized morbidity in Bulgaria remains without significant change in the examined period.30 Therefore the possible reasons to explain the decrease in the number of reimbursed patients might be low adherence rates to outpatient treatment,31 possibly difficult access to mental health care10 or significant stigma of mental illness17 that could be preventing the use of reimbursed medicines in outpatient settings. Another possible explanation might be a decrease in the cost of psychopharmacotherapy related to the entrance of generics with a lower price that might make psychotropic medications more affordable to buy out-of-pocket. The influence of generics might be a possible reason for the reduction of the costs as it was demonstrated for cardiovascular medicines by Mitkova et al.32

Although new modern medicines have been introduced for the therapy of psychiatric disorders and most of them are included in the treatment practice of Bulgarian patients, still, prescribers rely on well-established molecules.33,34 Similar to other studies, we report a stable use of anxiolytics, while sedatives and typical antipsychotics decrease by 26.4% and 61.2%, respectively.13 The utilization of all ATC groups is decreasing from 28.04 to 17.38 DDD/1000inh/day for 5-year period in Bulgaria, which is similar with the observed trend for the overall utilization of antipsychotics in Serbia and Montenegro: from 45.1 DDD/1000 inhabitants/day in 2000 to 69.1 DDD/1000 inhabitants/day in 2004.13 It is worth mentioning that Lithium, a well-established drug for the treatment of bipolar disorder, is not included in the Positive Drug List and is not available for use in Bulgaria.35

The main limitation of the study that it is only summarizing the publicly available macro indicators for the utilization of psychotropic drugs for major psychiatric disorders at a reimbursed level. Also, thymostabilizing agents such as carbamazepine and valproic acid are not included in the analysis due to the lack of disaggregated data by diagnosis from the NHIF database. However, the study can elucidate the lack of sufficient publicly available data on the real dispensing strategies in the country, regardless of health insurance status. Lack of such data is detrimental to the development of effective strategies for mental health care. The hypotheses about the possible reasons for these results require further investigation and could be used as a base for further analysis.

As Soumerai et al. reported, the limits on coverage for the costs of prescription drugs can increase the use of acute mental health services among low-income patients with chronic mental illnesses and increase the treatment costs paid by public funds.36 Therefore, further more detailed studies focusing on analysis of the Bulgarian patients’ access to reimbursable psychotropic medicines and the related factors are required.

Conclusion

The number of reimbursed patients with major psychiatric disorders in Bulgaria, as well as the cost of pharmacotherapy and utilization of psychotropic medicines, decreases during 2013–2017. Further analysis of the possible reasons is required to facilitate better and effective mental health care strategies.

Conflict of interest

The authors have no conflict of interest.

Funding

This work was supported by the Bulgarian Ministry of Education and Science under the National Program for Research ‘Young Scientists and Postdoctoral Students’.

Ethical considerations

The work does not involve any human beings or animals.

References
[1]
A. Gustavsson, M. Svensson, F. Jacobi, C. Allgulander, J. Alonso, E. Beghi, et al.
Cost of disorders of the brain in Europe 2010.
Eur Neuropsychopharmacol, 21 (2011), pp. 718-779
[2]
W. Rössler, H. Joachim Salize, J. van Os, A. Riecher-Rössler.
Size of burden of schizophrenia and psychotic disorders.
Eur Neuropsychopharmacol, 15 (2005), pp. 399-409
[3]
WHO. Premature death among people with severe mental disorders. http://www.who.int/mental_health/management/info_sheet.pdf. [Accessed 27 October 2017].
[4]
N. Craddock, M.J. Owen.
The Kraepelinian dichotomy — going, going… but still not gone.
Br J Psychiatry, 196 (2010), pp. 92-95
[5]
A.J. Ferrari, S. Saha, J.J. McGrath, R. Norman, A. Baxter, T. Vos, et al.
Health states for schizophrenia and bipolar disorder within the Global Burden of Disease 2010 Study.
Popul Health Metr, 10 (2012), pp. 16
[6]
GBD 2015 DALYs and HALE Collaborators, NJ, M. Arora, R.M. Barber, et al.
Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.
Lancet (London, England), 388 (2016), pp. 1603-1658
[7]
H. Killaspy, M. King, C. Wright, S. White, P. McCrone, T. Kallert, et al.
Study protocol for the development of a European measure of best practice for people with long term mental health problems in institutional care (DEMoBinc).
BMC Psychiatry, 9 (2009), pp. 36
[8]
T.M. Hillhouse, J.H. Porter.
A brief history of the development of antidepressant drugs: From monoamines to glutamate.
Exp Clin Psychopharmacol, 23 (2015), pp. 1-21
[9]
A.M. Ponizovsky, E. Marom, M. Ben-Laish, I. Barash, A. Weizman, E. Schwartzberg.
Trends in the use of antipsychotics in the Israeli inpatient population, 2004-2013.
Isr J Health Policy Res, 5 (2016), pp. 16
[10]
C. Levin, D. Chisholm.
Cost-effectiveness and affordability of interventions, policies, and platforms for the prevention and treatment of mental, neurological, and substance use disorders.
The International Bank for Reconstruction and Development/The World Bank, (2016), http://dx.doi.org/10.1596/978-1-4648-0426-7_CH12
[11]
N. Divac, D.L. Toševski, D. Babić, D. Djurić, M. Prostran, R. Samardžić.
Trends in consumption of psychiatric drugs in Serbia and Montenegro 2000-2004.
Pharmacoepidemiol Drug Saf, 15 (2006), pp. 835-838
[12]
Addis A, Batel-Marques F, Carvajal-M Sainz A, Folino-Gallo P, Jansen P, Ronning M. et al. EURO-MED-STAT Working Group on Recommendations for National Registers of Medicinal Products with Validated ATC Codes and DDD Values The Library Of European Union Pharmaceutical Indicators Recommendations for National Registers of Medicinal Products with Validated ATC Codes and DDD Values.
[13]
C.P. Stephenson, E. Karanges, I.S. McGregor.
Trends in the utilisation of psychotropic medications in Australia from 2000 to 2011.
Aust N Z J Psychiatry, 47 (2013), pp. 74-87
[14]
Mental health statistics: prevalence, services and funding in England — House of Commons Library. https://commonslibrary.parliament.uk/research-briefings/sn06988/. [Accessed 3 May 2020].
[15]
C. Mihalopoulos, P.D. McGorry, R.C. Carter.
Is phase-specific, community-oriented treatment of early psychosis an economically viable method of improving outcome.
Acta Psychiatr Scand, 100 (1999), pp. 47-55
[16]
L. Flyckt, A. Löthman, L. Jörgensen, A. Rylander, T. Koernig.
Burden of informal care giving to patients with psychoses: a descriptive and methodological study.
Int J Soc Psychiatry, 59 (2013), pp. 137-146
[17]
D. Ignatova, M. Kamusheva, G. Petrova, G. Onchev.
Burden of informal care for individuals with schizophrenia and affective disorders prior to hospital admission.
Eur J Psychiatry, 33 (2018), pp. 54-62
[18]
S.H. Zuvekas.
Prescription drugs and the changing patterns of treatment for mental disorders, 1996-2001.
Health Aff (Millwood), 24 (2005), pp. 195-205
[19]
National institute for health care management research and educational foundation prescription drug expenditures in 2001: another year of escalating costs, (2002),
[20]
A. Martin, D. Leslie.
Trends in psychotropic medication costs for children and adolescents, 1997-2000.
Arch Pediatr Adolesc Med, 157 (2003), pp. 997-1004
[21]
K.G. Piparva, D.M. Parmar, A.P. Singh, M.V. Gajera, H.R. Trivedi.
Drug utilization study of psychotropic drugs in outdoor patients in a teaching hospital.
Indian J Psychol Med, 33 (2011), pp. 54-58
[22]
S. Ilyas, J. Moncrieff.
Trends in prescriptions and costs of drugs for mental disorders in England, 1998–2010.
Br J Psychiatry, 200 (2012), pp. 393-398
[23]
D. Ignatova, M. Kamusheva, G. Petrova, G. Onchev.
Costs and outcomes for individuals with psychosis prior to hospital admission and following discharge in Bulgaria.
Soc Psychiatry Psychiatr Epidemiol, 54 (2019), pp. 1353-1362
[24]
A. Dimova, M. Rohova, E. Atanasova, P. Kawalec, K. Czok.
Drug policy in Bulgaria.
Value Health Reg Issues, 13 (2017), pp. 50-54
[25]
M. Vassileva, M. Kamusheva, M. Manova, A. Savova, K. Tachkov, G. Petrova.
Historical overview of regulatory framework development on pricing and reimbursement of medicines in Bulgaria.
Expert Rev Pharmacoecon Outcomes Res, 19 (2019), pp. 733-742
[26]
National Council on Prices and Reimburcement of Medical Products.
Positive drug list. Bulgaria.
[27]
National Council on Prices and Reimbursement of Medicinal Products. Official web site. Electronic registries. Available at: https://portal.ncpr.bg/registers/pages/register/list-medicament.xhtml.
[28]
R.E. Gewurtz, C. Cott, B. Rush, B. Kirsh.
How is unemployment among people with mental illness conceptualized within social policy? A case study of the Ontario Disability Support Program.
Work, 51 (2015), pp. 121-133
[29]
T. Burns, S.J. White, J. Catty.
Individual placement and support in Europe: the EQOLISE trial.
Int Rev Psychiatry, 20 (2008), pp. 498-502
[30]
Ministry of Health NC for PH and A.
Hospitalized morbidity in the Repuclic of Bulgaria for the period 2000-2017.
[31]
I. Valkova Yalamova.
Post-discharge medication adherence in schizophrenia.
Arch Psychiatry Psychother, 4 (2015), pp. 39-47
[32]
Z. Mitkova, M. Manova, PG.
Impact of the generic competition on reference prices of cardiovascular medicines.
Pharmacia, 61 (2014), pp. 9-16
[33]
J.H. Krystal, M.W. State.
Psychiatric disorders: diagnosis to therapy.
[34]
WHO.
Pharmacological treatment of mental disorders in primary health care.
World Health Organization, (2009),
[35]
R. Machado-Vieira, H.K. Manji, C.A. Zarate.
The role of lithium in the treatment of bipolar disorder: convergent evidence for neurotrophic effects as a unifying hypothesis.
Bipolar Disord, 11 (2009), pp. 92-109
[36]
S.B. Soumerai, T.J. McLaughlin, D. Ross-Degnan, C.S. Casteris, P. Bollini.
Effects of a limiting Medicaid drug-reimbursement benefits on the use of psychotropic agents and acute mental health services by patients with schizophrenia.
N Engl J Med, 331 (1994), pp. 650-655
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos