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Serum levels of catecholamine metabolites and return to work in patients with major depression: a preliminary study
Reiji Yoshimura
Corresponding author
yoshi621@med.uoeh-u.ac.jp

Corresponding author.
, Naomichi Okamoto, Yuki Konishi, Atsuko Ikenouchi
Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 8078555, Japan
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This study included 27 patients who met the DSM-5 criteria for MD &#40;M&#47;F&#58; 12&#47;15&#44; age&#58; 29&#8211;60 years&#41;&#46; We evaluated the severity of depressive state using the Hamilton Rating Scale for Depression &#40;HAMD&#41; at T0 and T8 following treatment with antidepressants&#46; All patients achieved remission within week 12 &#40;T12&#41;&#46; The patients who succeeded in RTW within 6 months following remission were categorized as the succeeding group&#44; whereas the others were categorized as the failure group&#46; All blood samples were taken at 7&#58;00 am before breakfast &#40;at least 12&#8239;h following the last medication&#41; at T0 and T8 following treatment with antidepressants&#46; Fifteen milliliters of venous blood was drawn&#44; with the patient in the supine position&#44; after the patient had rested overnight&#46; The serum samples were quickly separated in a centrifuge &#40;2000&#8239;g&#44; 10&#8239;min&#44; 4&#8239;&#176;C&#41; and stored at &#8722;80&#8239;&#176;C until assay&#46; The serum levels of MHPG and HVA were measured by high-performance liquid chromatography according to previously reported methods&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The study protocol was approved by the Ethics Committee of the University of Occupational and Environmental Health&#44; Kitakyushu&#44; Japan &#40;approval number&#58; H25-13&#59; May 8&#44; 2013&#41; and was conducted while upholding its ethical standards&#46; All the participants of the study signed an informed consent document explaining the study protocol and the potential risks involved&#46; All patients were administered selective serotonin&#47;serotonin noradrenaline reuptake inhibitors&#44; and achieved remission within T12&#46; The HAMD at T0 was higher in the successful group &#40;22&#46;94 &#91;2&#46;58&#93;&#44; mean &#91;standard deviation&#93;&#41; than in the failure group &#40;19&#46;9 &#91;1&#46;91&#93;&#44; <span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239; 0&#46;003&#41;&#46; Logistic regression analysis was performed with RTW success or failure as the objective variable&#46; Sex&#44; age&#44; changes in serum HVA levels&#44; and serum MHPG levels were independent of RTW&#46; The preliminary results indicate that peripheral levels of catecholamine metabolites during the acute phase of MD did not predict the success or failure of RTW within six months following remission&#46; Further studies to analyze more metabolites or account for the relationship between the drugs used and their influence on noradrenaline and dopamine metabolites&#44; and to reconfirm the preliminary results are warranted &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Ethical considerations</span><p id="par0010" class="elsevierStylePara elsevierViewall">The study protocol was approved by the Ethics Committee of the University of Occupational and Environmental Health&#44; Kitakyushu&#44; Japan &#40;approval number&#58; H25-13&#59; May 8&#44; 2013&#41;&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interest</span><p id="par0015" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Funding sources</span><p id="par0020" class="elsevierStylePara elsevierViewall">This research did not receive any specific grant from funding agencies in the public&#44; commercial&#44; or not-for-profit sectors&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Author contributions</span><p id="par0025" class="elsevierStylePara elsevierViewall">RY&#44; NO&#44; YK&#44; and AI contributed to conception and design&#44; were involved in the clinical investigations&#44; and wrote the manuscript&#46; All authors have read and approved the final manuscript&#46;</p></span></span>"
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                      "doi" => "10.1016/j.tics.2016.04.002"
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                        "fecha" => "2016"
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                        0 => array:2 [
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                          "autores" => array:5 [
                            0 => "S&#46; Rupprechter"
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                            2 => "Q&#46;J&#46;M&#46; Huys"
                            3 => "J&#46;D&#46; Steele"
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Article information
ISSN: 02136163
Original language: English
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