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Supported by the Hospital General de Pachuca, Secretaría de Salud, Hidalgo, México. " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:3 [ "entidad" => "Departamento de Patología, Hospital General de Pachuca, Secretaría de Salud, Hidalgo, México. Supported by the Hospital General de Pachuca, Secretaría de Salud, Hidalgo, México. " "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] 2 => array:3 [ "entidad" => "Academia Mexicana de Cito-patología, México. Supported by the Hospital General de Pachuca, Secretaría de Salud, Hidalgo, México. " "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] 3 => array:3 [ "entidad" => "Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, DF. Supported by the Hospital General de Pachuca, Secretaría de Salud, Hidalgo, México. " "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "affd" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Valor del cepillado de canal endocervical remanente durante LLETZ como predictor de enfermedad residual" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "305v10n05-90089426fig1.jpg" "Alto" => 425 "Ancho" => 987 "Tamanyo" => 35991 ] ] "descripcion" => array:1 [ "en" => "Results in 62 second specimens with both positive endocervical margins and endocervical brushing." ] ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">The contributions of the authors were as follows: JO: conception, design, and supervision of the study; RM: general design, medical examination, manuscript preparation, and data interpretation; FJDB: Pathologist to study the biopsies; BS: contributed to the experimental design; MG: general design, statistical analysis, and manuscript preparation. All authors agreed on the final version of the manuscript. Authors had no conflict of interest. </span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">¿ INTRODUCTION </span></p><p class="elsevierStylePara">Electrical excision of cervical lesions was first used in the nineteenth century. Hunner (1906) was the first reporting the use of therapeutic electrocauterization.<span class="elsevierStyleSup">1</span> Rene Cartier in 1981 adapted a small loop electrode using low voltage and in 1989 Walter Prendiville for the first time introduced radio frequencies to perform the excision of the cervical transformation zone using a large loop (LLETZ).<span class="elsevierStyleSup">2,3</span> This technique has become widely used and offers the advantages of obtaining a large specimen for histopathological diagnosis, it is well tolerated by patients when performed under local anesthesia on an outpatient basis, has few complications and side effects, and has a relatively low cost;<span class="elsevierStyleSup">4</span> in addition, it allows to correlate colposcopic impression with the histology, and micro-invasion can be ruled-out.<span class="elsevierStyleSup">5</span> Also, fertility is preserved. Disadvantages include post-treatment cervical stenosis,<span class="elsevierStyleSup">6</span> infections, bleeding,<span class="elsevierStyleSup">7</span> and thermal damage of the margins that may preclude an adequate study of the margins.<span class="elsevierStyleSup">4</span></p><p class="elsevierStylePara"> LLETZ is an effective treatment of cervical intraepithelial neoplasia (CIN) and thus avoids the progression to invasive carcinoma. </p><p class="elsevierStylePara">The persistence or recurrence of CIN following LLETZ is related to several factors such as degree of the disease,<span class="elsevierStyleSup">8</span> positive endocervical curettage,9 diagnosis of positive margins of the specimen.<span class="elsevierStyleSup">9-11</span> Ghaem-Maghami demonstrated that after incomplete resection, the relative risk (RR) of having a recurrence of disease of any degree was 5.47 (confidence interval [CI] 95% 4.37-6.83).<span class="elsevierStyleSup">12</span> Tan et al. report that only positive margins after LLETZ are an independent risk factor (p <0.05, odds ratio [OR] = 4.20)<span class="elsevierStyleSup">13</span> and Livasy comments on the presence of involved endocervical glands as a factor.<span class="elsevierStyleSup">14</span></p><p class="elsevierStylePara"> Chien-Hsing points out the usefulness of clinical indicators such as positive endocervical margins, age over 50, and disease in multiple quadrants as having a positive predictive value of 40%, 31.4% and 21.9%, respectively.<span class="elsevierStyleSup">15</span> The management of patients with residual lesions post LLETZ is still controversial. Incomplete resection is ignored on many occasions when patients are followed. Follow-up is also done by cytology, a second loop excision, and even hysterectomy. There are no reports in the literature on endocervical brushing of the cervix immediately post LLETZ with histological study of the specimen <span class="elsevierStyleItalic">vs.</span> endocervical brushing in cases with positive margins as a predictor of residual disease. </p><p class="elsevierStylePara"><span class="elsevierStyleBold">¿ OBJECTIVES </span></p><p class="elsevierStylePara">To study the concordance of positive predictive value of endocervical brushing performed immediately following LLETZ and histological results of cervical cones with positive endocervical margins, as predictors of residual disease. </p><p class="elsevierStylePara"><span class="elsevierStyleBold">¿ METHODS </span></p><p class="elsevierStylePara">A prospective study including 1817 patients referred with abnormal cytology and treated by LEETZ was undertaken at the Colposcopy Clinic, General Hospital of Pachuca, Hidalgo, Mexico. </p><p class="elsevierStylePara">The Ethics and Research Committee from the same hospital approved the protocol; informed consent was obtained from all patients.</p><p class="elsevierStylePara">Demographic data included age, educational level, marital status; reproductive data included number of pregnancies and children, age at sexual debut, number of sexual partners, and method of contraception; clinical data included previous cytological results, index cytology, Reid index,<span class="elsevierStyleSup">16</span> and Campion's level.17 </p><p class="elsevierStylePara">These 1877 patients underwent endocervical brushing of the remaining endocervical canal immediately after removing the specimen; 344 patients had a high grade intraepithelial lesion on cytology, histology, and colposcopy. In 62 patients margins were positive on histology and the endocervical brushing was also positive. These 62 patients underwent a new treatment (LEETZ or hysterectomy) within 6 (± 2) months. </p><p class="elsevierStylePara"> All 1877 patients were referred to the Colposcopy Clinic due to an abnormal cytology. On the first visit, colposcopy was performed and recorded using the modified Reid Colposcopic Index. Colposcopy-directed biopsies were obtained and sent for histo-pathological studies. On a second visit, a LLETZ was performed under local anesthesia. Each specimen was marked at 12 o'clock and reported by a single Pathologist. A second expert pathologist reviewed all 62 cases blinded to the previous results. An excellent concordance between both pathologists was reported (kappa = 0.95). All margins were considered acceptable for evaluation. </p><p class="elsevierStylePara"> Statistical analysis was performed on SPSS for Windows (version 10.00; SPSS Inc. Chicago, Ill.). Continuous variables were expressed as means and standard deviation; dichotomy variables as frequencies and percentages. To study group comparisons student´s t test for independent samples . A significant value was expressed using a two-tail p value <0.05. </p><p class="elsevierStylePara"><span class="elsevierStyleBold">¿ RESULTS </span></p><p class="elsevierStylePara">Mean age of the 344 patients with cytological and histological diagnosis of high grade intraepithelial lesion was 42.2 ± 12.5 years (range 20 - 80). The 62 cases with both positive endocervical margins and a positive cytobrush of the remaining canal had a second treatment: 46 hysterectomies and 16 second LLETZ. Findings showed 54 patients (87%) had residual lesion on the second specimen and 8 (13%) had a negative specimen (p <0.05) (<span class="elsevierStyleBold">Figure 1</span>). </p><p class="elsevierStylePara"><img src="305v10n05-90089426fig1.jpg" alt="Figure 1. Results in 62 second specimens with both positive endocervical margins and endocervical brushing. "></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold"> Figure 1. </span>Results in 62 second specimens with both positive endocervical margins and endocervical brushing. </p><p class="elsevierStylePara">The length, height and width of the cone were significantly different in patients with residual disease when compared with those from patients with negative margins and negative endocervical brushing (<span class="elsevierStyleBold">Table 1</span>). </p><p class="elsevierStylePara"><img src="305v10n05-90089426fig2.jpg" alt="Table 1. Comparison of patients with negative margins and a positive histological report for residual lesion."></img></p><p class="elsevierStylePara">There were no significant differences in demographic data, reproductive history, and clinical data between the group of patients with residual disease and the one with both negative margins and endocervical brushing. </p><p class="elsevierStylePara"><span class="elsevierStyleBold">¿ DISCUSSION </span></p><p class="elsevierStylePara">When the presence of a positive endocervical cytobrush and endocervical margins positive in a cone (LLETZ) specimen were combined, second specimens with residual lesion were obtained in 87% of the cases, i.e., such rate of positive specimens in the future may be predicted (positive predictive value). Residual lesion was seen in 8% of the cases (from 1817 LLETZ specimens). No other studies comparing Mexican rates have been published; however, rates reported in the international literature are quite variable (14% - 31%).<span class="elsevierStyleSup">18-21</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">¿ CONCLUSIONS </span></p><p class="elsevierStylePara">The positive predictive value of cone specimens with positive endocervical margins and concomitantly positive endocervical cytobrush of the proximal cervix is 87%. This knowledge may in the future allow choosing with reasonable certainty patients requiring a second treatment, and offering better results in the treatment of residual disease when taking into account these elegibility factors. </p><p class="elsevierStylePara"><span class="elsevierStyleBold">¿ ACKNOWLEDGMENT </span></p><p class="elsevierStylePara">To Fernando Guijon, MD for his commentaries on the manuscript and help in the translation. </p><hr></hr><p class="elsevierStylePara"><span class="elsevierStyleItalic">Corresponding Author</span>: Jorge Ojeda-Ortiz. <br></br> Departamento de Colpos-Departamento de Colposcopia, Hospital General de Pachuca - Carretera Pachuca-Tulancingo S/N Colonia Ciudad de los niños. Pachuca, Hidalgo. 42070, México. <br></br> Phone and Fax (52) 77 1718 2500. <br></br><span class="elsevierStyleItalic">Email:</span><a href="mailto:jorgeojeda@hotmail.com" class="elsevierStyleCrossRefs">jorgeojeda@hotmail.com</a></p>" "pdfFichero" => "305v10n05a90089426pdf001.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec176281" "palabras" => array:1 [ 0 => "LLETZ, enfermedad residual, predictivo, margen endocervical, México" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec176282" "palabras" => array:1 [ 0 => "LLETZ, residual disease, predictive, endocervical margin, Mexico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "Objetivo: Hay varios factores que determinan la persistencia o recurrencia de la neoplasia intraepitelial cervical después de una escisión con asa grande de la zona de transformación (LLETZ). El presente estudio estima que el valor predictivo positivo del cepillado endocervical del canal cervical remanente inmediatamente después de retirar la muestra LLETZ, como elemento predictivo de enfermedad residual. Métodos: Estudio prospectivo, llevado a cabo desde enero de 1990 hasta diciembre de 2006, en el Hospital General de Pachuca, Hidalgo, México. LLETZ se realizó en 1817 pacientes con un concomitante cepillado cervical para estudio citológico. 344 pacientes tuvieron lesiones intraepiteliales de alto grado en la citología, histología y la colposcopia. En 62 pacientes con diagnóstico de lesiones intraepiteliales de alto grado tanto en LLETZ como en cytobrush, se realizó un segundo tratamiento en 6 ± 2 meses, ya fuese con LLETZ (16 pacientes) o histerectomía (54 pacientes). La evaluación histológica fue realizada por dos patólogos, cada uno desconocía el diagnóstico del otro patólogo (cegado). El análisis estadístico se realizó mediante t-test y prueba de ji cuadrada con el programa SPSS v10.0 (SPSS Inc., Chicago, IL). Resultados: Tras el segundo tratamiento de 62 pacientes, 87% (54 pacientes) tenían una lesión histológica probada residual y 13% (8 pacientes) no tenían enfermedad residual; estos resultados tuvieron significación estadística (p <0 05 conclusiones: cuando los márgenes endocervical y el cepillado cervical son positivos de forma concomitante existe un alto valor predictivo 87 tener la enfermedad residual según se muestra en segundo espécimen" ] "en" => array:1 [ "resumen" => "Objective: There are several factors which determine the persistence or recurrence of cervical intraepithelial neoplasia after a large-loop excision of the transformation zone (LLETZ). The current study estimates the positive predictive value of endocervical brushing of the remaining cervical canal immediately after removing the LLETZ specimen, as a predictive element of a residual disease. Methods: Prospective study carried out from January 1990 to December 2006, at General Hospital of Pachuca, Hidalgo, Mexico. LLETZ was performed in 1817 patients undergoing concomitant cervical brushing for cytological study; 344 patients had a high grade intraepithelial lesion on cytology, histology, and colposcopy. In 62 patients with diagnosis of high grade intraepithelial lesion in both LLETZ and cytobrush, a second treatment was performed within 6 ± 2 months either with LLETZ (16 patients) or hysterectomy (54 patients). Histological evaluation was performed by two pathologist, each blinded to the diagnosis of a pathologist. Statistical analyses were performed by t-test and2 test using SPSS v10.0 (SPSS Inc., Chicago, IL). Results: Following the second treatment performed in 62 patients, 87% (54 patients) had a histological proven residual lesion and 13% (8 patients) had no residual disease; these results had a statistical significance of p <0 05 conclusions: when endocervical margins and cervical brushing are concomitantly positive there is a high predictive value 87 of having residual disease as demonstrated in second specimen" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "305v10n05-90089426fig1.jpg" "Alto" => 425 "Ancho" => 987 "Tamanyo" => 35991 ] ] "descripcion" => array:1 [ "en" => "Results in 62 second specimens with both positive endocervical margins and endocervical brushing." ] ] 1 => array:8 [ "identificador" => "tbl1" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tablaImagen" => array:1 [ 0 => array:4 [ "imagenFichero" => "305v10n05-90089426fig2.jpg" "imagenAlto" => 591 "imagenAncho" => 1008 "imagenTamanyo" => 85134 ] ] ] ] ] "descripcion" => array:1 [ "en" => "Comparison of patients with negative margins and a positive histological report for residual lesion." ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:21 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Electrosurgery for HPV-related diseases of the lower genital tract." 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Original language: English
Year/Month | Html | Total | |
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2024 May | 20 | 8 | 28 |
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2024 February | 18 | 18 | 36 |
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2023 October | 18 | 6 | 24 |
2023 September | 26 | 6 | 32 |
2023 August | 26 | 4 | 30 |
2023 July | 30 | 11 | 41 |
2023 June | 18 | 6 | 24 |
2023 May | 26 | 5 | 31 |
2023 April | 21 | 8 | 29 |
2023 March | 15 | 1 | 16 |
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2022 October | 22 | 6 | 28 |
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2021 December | 29 | 14 | 43 |
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2020 December | 13 | 16 | 29 |
2020 November | 14 | 12 | 26 |
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2020 September | 10 | 9 | 19 |
2020 August | 14 | 9 | 23 |
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2020 June | 8 | 6 | 14 |
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2020 April | 13 | 7 | 20 |
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2019 December | 11 | 13 | 24 |
2019 November | 13 | 9 | 22 |
2019 October | 15 | 5 | 20 |
2019 September | 16 | 1 | 17 |
2019 August | 8 | 5 | 13 |
2019 July | 7 | 10 | 17 |
2019 June | 21 | 9 | 30 |
2019 May | 33 | 28 | 61 |
2019 April | 2 | 25 | 27 |
2019 March | 6 | 2 | 8 |
2019 February | 6 | 10 | 16 |
2019 January | 3 | 6 | 9 |
2018 December | 1 | 3 | 4 |
2018 November | 4 | 2 | 6 |
2018 October | 2 | 12 | 14 |
2018 September | 5 | 0 | 5 |
2018 August | 6 | 5 | 11 |
2018 July | 6 | 3 | 9 |
2018 June | 10 | 2 | 12 |
2018 May | 10 | 3 | 13 |
2018 April | 8 | 4 | 12 |
2018 March | 5 | 0 | 5 |
2018 February | 4 | 2 | 6 |
2018 January | 9 | 1 | 10 |
2017 December | 5 | 0 | 5 |
2017 November | 5 | 1 | 6 |
2017 October | 3 | 1 | 4 |
2017 September | 8 | 5 | 13 |
2017 August | 3 | 3 | 6 |
2017 July | 5 | 4 | 9 |
2017 June | 9 | 3 | 12 |
2017 May | 14 | 5 | 19 |
2017 April | 12 | 4 | 16 |
2017 March | 13 | 35 | 48 |
2017 February | 19 | 2 | 21 |
2017 January | 16 | 1 | 17 |
2016 December | 16 | 1 | 17 |
2016 November | 18 | 1 | 19 |
2016 October | 16 | 2 | 18 |
2016 September | 10 | 1 | 11 |
2016 August | 7 | 0 | 7 |
2016 July | 32 | 4 | 36 |
2016 June | 118 | 12 | 130 |
2016 May | 70 | 14 | 84 |
2016 April | 51 | 23 | 74 |
2016 March | 51 | 10 | 61 |
2016 February | 29 | 13 | 42 |
2016 January | 67 | 20 | 87 |
2015 December | 135 | 10 | 145 |
2015 November | 103 | 4 | 107 |
2015 October | 75 | 4 | 79 |
2015 September | 89 | 11 | 100 |
2015 August | 118 | 4 | 122 |
2015 July | 67 | 5 | 72 |
2015 June | 135 | 0 | 135 |
2015 May | 103 | 2 | 105 |
2015 April | 64 | 7 | 71 |
2015 March | 67 | 5 | 72 |
2015 February | 84 | 3 | 87 |
2015 January | 78 | 1 | 79 |
2014 December | 110 | 7 | 117 |
2014 November | 105 | 2 | 107 |
2014 October | 154 | 3 | 157 |
2014 September | 97 | 3 | 100 |
2014 August | 134 | 2 | 136 |
2014 July | 113 | 4 | 117 |
2014 June | 67 | 3 | 70 |
2014 May | 74 | 2 | 76 |
2014 April | 77 | 2 | 79 |
2014 March | 86 | 11 | 97 |
2014 February | 80 | 11 | 91 |
2014 January | 90 | 5 | 95 |
2013 December | 47 | 12 | 59 |
2013 November | 22 | 3 | 25 |
2013 October | 22 | 8 | 30 |
2013 September | 38 | 12 | 50 |
2013 August | 35 | 9 | 44 |
2013 July | 34 | 11 | 45 |
2013 June | 24 | 4 | 28 |
2013 May | 28 | 12 | 40 |
2013 April | 24 | 12 | 36 |
2013 March | 23 | 7 | 30 |
2013 February | 9 | 2 | 11 |
2013 January | 11 | 5 | 16 |
2012 December | 5 | 3 | 8 |
2012 November | 8 | 2 | 10 |
2012 October | 19 | 10 | 29 |
2012 September | 0 | 1 | 1 |
2011 August | 1084 | 0 | 1084 |