metricas
covid
Buscar en
Gastroenterología y Hepatología
Toda la web
Inicio Gastroenterología y Hepatología Epidemiología, diagnóstico, complicaciones y cirugía en la enfermedad inflama...
Journal Information
Vol. 35. Issue S1.
Jornada de Actualización en Gastroenterología Aplicada
Pages 51-56 (September 2012)
Share
Share
Download PDF
More article options
Vol. 35. Issue S1.
Jornada de Actualización en Gastroenterología Aplicada
Pages 51-56 (September 2012)
Full text access
Epidemiología, diagnóstico, complicaciones y cirugía en la enfermedad inflamatoria intestinal
Epidemiology, diagnosis, complications and surgery in inflammatory bowel disease
Visits
4005
Beatriz Sicilia
Corresponding author
bsicilia4@gmail.com

Correo electrónico.
Servicio de Aparato Digestivo, Hospital Universitario de Burgos (HUBU), Burgos, España
This item has received
Article information
Resumen

En esta reunión de la DDW 2012 (Digestive Disease Week 2012) celebrada en San Diego se han presentado múltiples trabajos en relación con la epidemiología de las enfermedades inflamatorias intestinales, algunos de ellos poblacionales, que nos aportan mayor información sobre factores de riesgo ya descritos en la bibliografía y, por otra parte, nos ayudan a eliminar algunos de ellos propuestos sin ninguna evidencia científica. Especial atención se ha prestado en esta reunión a los hallazgos, tanto en evolución natural como en cirugía, de los pacientes mayores de 65 años que claramente han de tratarse como un subgrupo de población “diferente” al de la población estándar de los ensayos clínicos de los que están excluidos. Otro apartado especialmente importante ha sido el de las complicaciones y manifestaciones extraintestinales con Clostridium difficile y la colangitis esclerosante primaria como principales protagonistas. Finalmente, y referentes al diagnóstico, la calprotectina se confirma como marcador imprescindible en diferentes escenarios, y nuevas técnicas de imagen como la cromoendoscopia virtual (i-scan) buscan su posición en el manejo de estos pacientes.

Palabras clave:
Enfermedad inflamatoria intestinal
Colitis ulcerosa
Enfermedad de Crohn
Epidemiología
Diagnóstico
Historia natural
Complicaciones
Cirugía
Abstract

In Digestive Disease Week 2012, held in San Diego, numerous studies were presented on the epidemiology of inflammatory bowel disease. Some of these studies were population-based, providing greater information on known risk factors and helping to eliminate proposed risk factors for which there is no known evidence. In this meeting, special attention was paid to the natural history of the disease as well as surgery in patients aged more than 65 years old who should clearly be treated as a separate subgroup from the standard population in clinical trials from which older individuals are excluded. Another especially important topic were extraintestinal complications and manifestations, with Clostridium difficile and primary sclerosing cholangitis as the main culprits. Finally, with reference to diagnosis, calprotectin was confirmed as an essential marker in distinct scenarios and new imaging techniques such as virtual chromoendoscopy (i-scan) will be important in the management of these patients, although their precise role remains to be defined.

Keywords:
Inflammatory bowel disease
Ulcerative colitis
Crohn's disease
Epidemiology
Diagnosis
Natural history
Complications
Surgery
Full text is only aviable in PDF
Bibliografía
[1.]
C. Saro, B. Sicilia.
Incidence of IBD; is still increasing?.
World J Gastroenter, 14 (2008), pp. 5491-5498
[2.]
J. Burisch, B. Xia, S. Cukovic-Cavka, J. Kaimakliotis, D. Duricova, O. Shonova, et al.
Is There an east-west gradient in the incidence of IBD in Europe? and further far east in China? first results from the Epicom Study.
Gastroenterology, 142 (2012), pp. S569-S570
[3.]
J.S. Siffledeen, K.M. Fleming, C. Crooks, T.R. Card.
Adult and pediatric IBD incidence in the UK: A large population-based study using the general practice research database.
Gastroenterology, 142 (2012), pp. S797
[4.]
N. Rossen, B.D. Van Rhijn, E.P. Karregat, K. Boonstra, P.J. Kingma, A.H. Naber, et al.
Epidemiology and characteristics of inflammatory bowel disease in a large population-based cohort in central Netherlands.
Gastroenterology, 142 (2012), pp. S793
[5.]
J. Zhao, S.C. Ng, J. Burisch, Y. Lei, J. Li, K. Zou, et al.
First prospective, population-based inflammatory bowel disease incidence study in China - the emergence of “western” disease.
Gastroenterology, 142 (2012), pp. S792
[6.]
R. Salas, O.O. Sepulveda, C. Cofre, P. Ibáñez, S.M. Bueno, A.M. Kalergis, et al.
Survival & cause-specific mortality of chilean inflammatory bowel disease patients.
Gastroenterology, 142 (2012), pp. S261
[7.]
C.P. Selinger, J.M. Andrews, O. Dent, R.W. Leong.
Survival over >20 years in a large Australian metropolitan cohort of inflammatory bowel disease patients: no excess overall mortality.
Gastroenterology, 142 (2012), pp. S252
[8.]
A. Peneau, J. Salleron, M. Fumery, G. Savoye, E. Lerebours, J.L. Dupas, et al.
Long-term outcome of paediatric-onset Crohn's disease: a population-based study.
Gastroenterology, 142 (2012), pp. S25
[9.]
C. Gower-Rousseau, G. Savoye, D. Turck, M. Fumery, J. Salleron, A. Peneau, et al.
Mortality and cancer in paediatric inflammatory bowel disease: a population-based study.
Gastroenterology, 142 (2012), pp. S661
[10.]
C. Castaño-Milla, M. Chaparro, J.P. Gisbert.
Has the risk of developing colorectal cancer in patients with ulcerative colitis been overstated? a meta-analysis.
Gastroenterology, 142 (2012), pp. S251
[11.]
A.N. Ananthakrishnan, H. Khallili, A. Pan, L.M. Higuchi, P.S. De Silva, J.M. Rochter, et al.
A prospective study of depressive symptoms and risk of Crohn's disease and ulcerative colitis.
Gastroenterology, 142 (2012), pp. S88
[12.]
H. Khallili, L.M. Higuchi, A.N. Ananthakrishnan, J.M. Richter, C.S. Fuchs, A.T. Chan.
Reproductive factors and risk of ulcerative colitis and Crohn's disease: results from two large prospective cohorts of US women.
Gastroenterology, 142 (2012), pp. S89
[13.]
H. Khallili, L.M. Higuchi, A.N. Ananthakrishnan, J.M. Richter, C.S. Fuchs, A.T. Chan.
Hormonal replacement therapy and risk of ulcerative colitis and Crohn's disease among postmenopausal women: results from a large prospective cohort of US women.
Gastroenterology, 142 (2012), pp. S88-S89
[14.]
F.D. Van Schaik, B. Oldenburg, A. Hart, P.D. Siersema, M.G. Van Oijen, H.B. Bueno-de Mesquita.
Serological markers can predict inflammatory bowel disease years before the diagnosis: results from a nested case-control study within a European cohort study.
Gastroenterology, 142 (2012), pp. S39
[15.]
P. Jantchou, F. Carbonnel, A. Hart, F. Clavel-Chapelon, M.C. Boutron-Ruault.
Dietary protein intake and risk of Crohn's disease: results of a prospective European cohort study.
Gastroenterology, 142 (2012), pp. S89
[16.]
J.B. Essers, S. Ripke, B. Neale, R.J. Xavier, M. Vu, M. Dubinsky, et al.
Genetics, serologies, and smoking predict highly morbid Crohn's disease in erroneously diagnosed UC patients.
Gastroenterology, 142 (2012), pp. S39-S40
[17.]
S.E. Plevy, T.P. Stockfish, S. Lockton, L.J. Croner, S. Singh, F. Princen.
Combined serologic, genetic, and inflammatory markers can accurately differentiate non-IBD, Crohn's disease, and ulcerative colitis patients.
Gastroenterology, 142 (2012), pp. S41
[18.]
S.Y. Shaw, J.F. Blanchard, C.N. Bernstein.
Early childhood immunizations are not associated with pediatric IBD: A population-based analysis.
Gastroenterology, 142 (2012), pp. S88
[19.]
A. Racine, A. Cuerq, A. Bijon, P. Ricordeau, H. Allemand, M.C. Boutron-Ruault, et al.
Isotretinoin use and risk of inflammatory bowel disease: a case control study from the French National Health Insurance System.
Gastroenterology, 142 (2012), pp. S88
[20.]
C. Charpentier, L. Dauchet, G. Savoye, M. Fumery, J. Salleron, V. Merle, et al.
Clinical and phenotypic characteristics of ulcerative colitis at diagnosis according to age: a population-based study.
Gastroenterology, 142 (2012), pp. S24-S25
[21.]
C. Charpentier, J. Salleron, G. Savoye, M. Fumery, L. Dauchet, J.L. Dupas, et al.
Clinical and phenotypic characteristics of Crohn's disease in elderly people: a population-based study.
Gastroenterology, 142 (2012), pp. S253
[22.]
F. Casals-Seoane, M. Chaparro, J.P. Gisbert.
The natural history of Crohn's disease: a long-term (> 10 years) follow-up study.
Gastroenterology, 142 (2012), pp. S254
[23.]
F. Casals-Seoane, M. Chaparro, J.P. Gisbert.
The natural history of Crohn's disease: impact of the introduction of thiopurines on its outcome.
Gastroenterology, 142 (2012), pp. S254
[24.]
D. Laharie, J. Filippi, X. Roblin, S. Nancey, J.B. Chevaux, X. Hebuterne, et al.
Impact of mucosal healing on long-term outcomes in ulcerative colitis treated with infliximab: a multicenter experience.
Gastroenterology, 142 (2012), pp. S363
[25.]
L.A. Feagins, S.D. Melton, R. Iqbal, K.B. Dunbar, S.J. Spechler.
Clinical Implications of Endoscopic and Histological Signs of Active Colitis in Patients With Ulcerative Colitis in Clinical Remission.
Gastroenterology, 142 (2012), pp. S655
[26.]
N. Inoue, K. Takabayashi, K. Matsuoka, T. Hisamatsu, T. Kanai, H. Ogata, et al.
Complete mucosal healing is associated with longterm remission in ulcerative colitis.
Gastroenterology, 142 (2012), pp. S383
[27.]
A. Schoepfer, C. Beglinger, A. Straumann, E. Safroneeva, Y. Romero, D. Armstrong.
Fecal calprotectin more accurately reflects endoscopic activity of ulcerative colitis than the lichtiger index CRP or blood leukocytes.
Gastroenterology, 142 (2012), pp. S114
[28.]
V. Aggarwal, A.S. Day, S.J. Connor, S.T. Leach, G.J. Brown, Singh., et al.
Multicenter capsule endoscopy study of small bowel Crohn's disease patients in clinical remission: long term follow up and correlation with faecal biomarkers and clinical outcome.
Gastroenterology, 142 (2012), pp. S169
[29.]
S. Nepal, R. Bahura, B. Shen, A. Atreja.
Development and validation of a nove enterography.based stricture severity score (SSS) to predicti the need of surgery in patinets with stricturing Crohn's disease.
Gastroenterology, 142 (2012), pp. S190-S191
[30.]
Bisschops R, Bisschops R, Bessissow T, Baert FJ, Ferrante M, Ballet V, Willekens H, et al. Chromo-endoscopy versus narrow band imaging in ulcerative colitis: a prospective randomized controlled trial. Gastrointestinal Endoscopy. 75 Suppl:AB148.
[31.]
Neumann H, Vieth M, Grauer M, Mudter J, Gunther G, Atreja R, et al. Virtual chromoendoscopy with i-scan for diagnosis of mucosal healing in patients with inflammatory bowel disease - a randomized double-blind controlled study. Gastrointestinal Endoscopy. 75 Suppl:AB147.
[32.]
P. Feuerstadt, D.R. Berg, S. Reddy, R. Das, O.C. Aroniadis, L.J. Brandt.
Biopsy-proven ulcerative colitis (UC) complicated by C. difficile infection (CDI) is associated with increased rates of colectomy.
Gastroenterology, 142 (2012), pp. S783
[33.]
A.N. Ananthakrishnan, R. Guzmán Pérez, V.S. Gainer, S.N. Murphy.
Predictors of severe Clostridium difficile infection in patients with inflammatory bowel disease.
Gastroenterology, 142 (2012), pp. S664-S665
[34.]
S. Khanna, E.V. Loftus, L. Baddour, D.S. Pardi.
Incidence and outcomes from Clostridium difficile infection in hospitalized adults with inflammatory bowel disease.
Gastroenterology, 142 (2012), pp. S112
[35.]
H.A. Horton, S. Dezfoli, D. Berel, J. Hirsch, S.R. Targan, A. Ippoliti, et al.
Patients with ulcerative colitis hospitalized with Clostridium difficile infection (CDI) should be treated with vancomycin regardless of CDI severity.
Gastroenterology, 142 (2012), pp. S123
[36.]
U. Navaneethan, P.G.K. Venkatesh, S. Mukewar, B. Lashner, F.H. Remzi, P.R. Kiran, et al.
Impact of ulcerative colitis on the long term outcome of patients with primary sclerosing cholangitis.
Gastroenterology, 142 (2012), pp. S8
[37.]
U. Navaneethan, S. Mukewar, P.G.K. Venkatesh, B. Lashner, F.H. Remzi, P.R. Kiran, et al.
Impact of Crohn's disease on the long term outcome of patients with primary sclerosing cholangitis.
Gastroenterology, 142 (2012), pp. S260-S261
[38.]
K. Jorgensen, L. Lindstrom, M. Cvancarova, E. Schrumpf, M.H. Vatn, K.M. Boberg.
Clinical course of inflammatory bowel disease in liver transplanted PSC patients: a Nordic multicenter study.
Gastroenterology, 142 (2012), pp. S7-S8
[39.]
A.D. Frolkis, J. Dykeman, M.E. Negron, J. De Bruyn, N. Jette, K.P. Rioux, et al.
Cumulative incidence of first intestinal surgery in adult and pediatric Crohn's disease: a systematic review and meta-analysis.
Gastroenterology, 142 (2012), pp. S790
[40.]
M.E. Negron, A.D. Frolkis, J. Dykeman, H. Barkema, K.P. Rioux, J. De Buck, et al.
Risk of surgery following diagnosis in adult and pediatric ulcerative colitis patients: a systematic review and meta-analysis.
Gastroenterology, 142 (2012), pp. S797
[41.]
P. Leonard, M. Yang, J. Chao, P. Mulani.
Complications associated with colectomy in patients with ulcerative colitis.
Gastroenterology, 142 (2012), pp. S401
[42.]
V. Pabby, S. Shah, A.S. Cheifetz, R. Burakoff, S. Friedman.
In vitro fertilization in patients with ulcerative colitis and ileal pouch anastomosis.
Gastroenterology, 142 (2012), pp. S68
[43.]
A. Cañas-Ventura, L. Márquez, J. Panes, E. Domenech, J.P. Gisbert, V. García-Sánchez, et al.
Risk of colectomy in patients with ulcerative colitis under thiopurine treatment Study of Prevalence and Predictive Factors. Eneida Project.
Gastroenterology, 142 (2012), pp. S384
[44.]
V. Pittet, G. Rogler, P.F. Michetti, N. Fournier, J.-P. Vader, A. Schoepfer, et al.
Medical treatments and risk factors for resection surgery in Crohn's disease: results from the Swiss IBD Cohort Study.
Gastroenterology, 142 (2012), pp. S569
[45.]
M. Juneja, M. Regueiro, M.A. Dunn, A. Barrie, D.G. Binion.
Surgical outcomes in geriatric ulcerative colitis: a tertiary referral center experience.
Gastroenterology, 142 (2012), pp. S257-S258
[46.]
M. Juneja, M. Regueiro, M.A. Dunn, A. Barrie, D.G. Binion.
Surgery in geriatric Crohn's disease patients requiring hospitalization.
Gastroenterology, 142 (2012), pp. S258
[47.]
M.C. Bautista, M.F. Otterson, Y. Zadvornova, D. Eastwood, A.S. Naik, D.J. Stein, et al.
Surgical outcomes in the elderly with inflammatory bowel disease.
Gastroenterology, 142 (2012), pp. S254-S255
[48.]
A. Armuzzi, C. Felice, M. Marzo, D. Pugliese, G. Andrisani, A. Papa, et al.
Prevention of postoperative recurrence with azathioprine or anti-tnf alpha in patients with crohn's disease: an open-label pilot study.
Gastroenterology, 142 (2012), pp. S780
[49.]
M. Aguas, G. Bastida, E. Cerrillo, B. Beltran, M. Iborra, F. Muñoz, et al.
Impact of adalimumab in the prevention of postoperative recurrences of Crohn's disease in high-risk patients.
Gastroenterology, 142 (2012), pp. S384
[50.]
Koriche D, Salleron J, Gower-Rousseau C, Cortot A, Colombel J-F, Zerbib P. Recurrence of Crohn's disease after definitive stoma: a retrospective study in 83 patients.
[51.]
T. Nuñes, M.J. Etchevers, O. Merino, S. Gallego, V. García-Sánchez, I. Marín Jiménez, et al.
High smoking cessation rate in crohns disease patients attending a multicenter anti-tobacco program: the TABACROHN Study.
Gastroenterology, 142 (2012), pp. S76
[52.]
J. Gisbert, J.R. Villagrasa, A. Rodríguez Nogueiras, M. Chaparro.
Efficacy of hepatitis B vaccination and re-vaccination and factors impacting on the response in inflammatory bowel disease patients.
Gastroenterology, 142 (2012), pp. S362
Copyright © 2012. Elsevier España, S.L.. Todos los derechos reservados
Download PDF
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos