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Inicio Gastroenterología y Hepatología Últimos avances en pancreatitis aguda
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Vol. 35. Issue S1.
Jornada de Actualización en Gastroenterología Aplicada
Pages 98-101 (September 2012)
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Vol. 35. Issue S1.
Jornada de Actualización en Gastroenterología Aplicada
Pages 98-101 (September 2012)
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Últimos avances en pancreatitis aguda
Latest advances in acute pancreatitis
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8257
Enrique de-Madaria
Unidad de Patología Pancreática, Hospital General Universitario de Alicante, Alicante, España
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Resumen

Las enfermedades cardiovasculares podrían ser un factor de riesgo para la pancreatitis aguda (PA), en concreto la hipertensión arterial y la cardiopatía isquémica. El tabaquismo se asocia a PA (odds ratio, 2,34), siendo la asociación menos marcada que con pancreatitis crónica. Además puede asociarse a peor pronóstico en la PA. El sistema pronóstico BISAP tiene una capacidad de predicción de mortalidad similar a APACHE II, siendo su cálculo mucho más sencillo. La resonancia magnética es una técnica de imagen segura (no se produce irradiación del paciente) y útil en el diagnóstico de complicaciones, en la predicción de gravedad y en la toma de decisiones clínicas. La trombosis venosa peripancreática es frecuente en la PA, y raramente se asocia a sangrado por varices gástricas o a isquemia mesentérica. El tratamiento de la necrosis pancreática organizada por drenaje endoscópico y percutáneo combinados es seguro y efectivo, permitiendo ahorrar la cirugía. La administración de fluidoterapia agresiva no parece mejorar la evolución de los pacientes con PA. La administración de nutrición enteral precoz en PA levemoderada disminuye el dolor abdominal y el riesgo de intolerancia a realimentación oral.

Palabras clave:
Pancreatitis aguda
Etiología
Pronóstico
Tratamiento
Diagnóstico
Abstract

Cardiovascular diseases could be a risk factor for acute pancreatitis (AP), specifically hypertension and ischemic heart disease. Smoking is associated with AP (OR 2.34), with the association being less marked than with chronic pancreatitis. Moreover, smoking may worsen the prognosis of AP. The bedside index for severity in AP (BISAP) prognostic system has a similar ability to predict mortality to the Acute Physiology and Chronic Health Evaluation II (APACHE II) index and is much simpler to calculate. Magnetic resonance imaging is a safe technique (it does not radiate the patient) and is useful in the diagnosis of complications, severity prediction and clinical decision making. Peripancreatic venous thrombosis is frequent in AP and is rarely associated with gastric variceal bleeding or mesenteric ischemia. The treatment of organized pancreatic necrosis by combined endoscopic and percutaneous drainage is safe and effective, avoiding the need for surgery. Aggressive fluid therapy does not seem to improve the outcome of patients with AP. The administration of early enteral nutrition in mild-moderate AP reduces abdominal pain and the risk of intolerance of oral refeeding.

Keywords:
Acute pancreatitis
Etiology
Prognosis
Treatment
Diagnosis
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Bibliografía
[1.]
M.J. Bruno, E.P. Dellinger, C.E. Forsmark, P. Layer, P. Levy, E. Maravi-Poma, et al.
Determinant-based classification of acute pancreatitis severity: an international multidisciplinary consultation.
Ann Surg, (2012),
[2.]
T.S. Bexelius, R. Ljung, F. Mattsson, J. Lagergren.
Cardiovascular disease and risk of acute pancreatitis in a population-based study.
Gastroenterology, 142 (2012), pp. S316
[3.]
E. Bjornsson, J.K. Nielsen.
Lifetime alcohol intake and pattern of alcohol consumption in patients with alcohol induced pancreatitis.
Gastroenterology, 142 (2012), pp. S316
[4.]
S. Janarthanan, D.G. Adler.
Smoking and its association to acute and chronic pancreatitis; a meta-analysis to establish overall risk.
Gastroenterology, 142 (2012), pp. S850
[5.]
W.C. Liao, H.H. Lin, H.Y. Chang.
Cigarette smoking, alcohol consumption, and the risk of pancreatitis: a population-based cohort study in Taiwan.
Gastroenterology, 142 (2012), pp. S54
[6.]
J.J. Easler, V. Muddana, V. Singh, D. Yadav, D.C. Whitcomb, G.I. Papachristou.
Cigarette smoking is a risk for persistent organ failure in patients with acute pancreatitis.
Gastroenterology, 142 (2012), pp. S319
[7.]
A. Thevenot, B. Bournet, P. Otal, A. Arlix, J. Moreau, J.R. Escourrou, et al.
Prospective comparative evaluation of the role of endoscopic ultrasound and magnetic resonance cholangiopancreatography for the diagnosis of idiopathic acute pancreatitis.
Gastroenterology, 142 (2012), pp. S851
[8.]
S. Appasani, R.B. Thandassery, I. Abujam, T.D. Yadav, K. Singh, R. Kochhar.
Myriads of markers and scoring systems for multiple events in acute pancreatitis: which do we mix and when do we match?.
Gastroenterology, 142 (2012), pp. S314
[9.]
V.K. Singh, B.U. Wu, T.L. Bollen, K. Repas, R. Maurer, R.S. Johannes, et al.
A prospective evaluation of the bedside index for severity in acute pancreatitis score in assessing mortality and intermediate markers of severity in acute pancreatitis.
Am J Gastroenterol, 104 (2009), pp. 966-971
[10.]
G.I. Papachristou, V. Muddana, D. Yadav, M. O’Connell, M.K. Sanders, A. Slivka, et al.
Comparison of BISAP, Ranson's, APACHE-II, and CTSI scores in predicting organ failure, complications, and mortality in acute pancreatitis.
Am J Gastroenterol, 105 (2010), pp. 435-441
[11.]
E. De-Madaria, J. Sánchez-Payá, B.U. Wu, G. Soler-Sala, I. López- Font, V.K. Singh, et al.
BISAP versus APACHE II for the prediction of mortality in acute pancreatitis: results of a cohort of patients and meta-analysis.
Gastroenterology, 142 (2012), pp. S847
[12.]
E.L. Bradley III.
A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis. Atlanta, Ga. September 11 through 13, 1992.
Arch Surg, 128 (1993), pp. 586-590
[13.]
R.B. Thandassery, T.D. Yadav, U. Dutta, S. Appasani, K. Singh, R. Kochhar.
Severity stratification in acute pancreatitis: prospective validation of a new four tier classification.
Gastroenterology, 142 (2012), pp. S315
[14.]
M. Arvanitakis, H. Rodrigues Duarte, S. El Bacha, A. Lemmers, E. Toussaint, P. Eisendrath, et al.
Diffusion-weighted magnetic resonance imaging and characterisation of pancreatic fluid collections: preliminary results.
Gastroenterology, 142 (2012), pp. S314-S315
[15.]
M. Kang, K. Rahul, D.K. Bhasin, R. Gupta, N. Kalra, A. Bhalla, et al.
Comparative performance of CT and MRI in prognostication of acute pancreatitis: correlation with clinical outcome.
Gastroenterology, 142 (2012), pp. S93
[16.]
S.R. Shroff, K. Bidari, M.P. Roth, L. Keefer, S. Komanduri.
The overutilization of abdominal computed tomography for the evaluation of acute pancreatitis.
Gastroenterology, 142 (2012), pp. S315
[17.]
A. Khaliq, R. Kashyap, M. Manrai, R. Kochhar, A. Bhattacharya, B.R. Mittal, et al.
Ammonia(NH3) –positron emission tomography– computed tomography (PETCT) in acute pancreatitis.
Gastroenterology, 142 (2012), pp. S63
[18.]
V. Muddana, J.J. Easler, A. Slivka, D.C. Whitcomb, G.I. Papachristou, D. Yadav.
Prevalence, risk factors and management of peripancreatic venous thrombosis (PPVT) in acute pancreatitis (AP).
Gastroenterology, 142 (2012), pp. S320
[19.]
A.S. Ross, S. Irani, S.I. Gan, M. Fotoohi, E. Hauptmann, J. Siegal, et al.
Combined endoscopic and perctaneous drainage of symptomatic walled-off pancreatic necrosis: long term follow-up of a large patient cohort.
Gastroenterology, 142 (2012), pp. S315-S316
[20.]
M.L. Cheatham, K. Safcsak.
Intraabdominal pressure: a revised method for measurement.
J Am Coll Surg, 186 (1998), pp. 368-369
[21.]
V. Bhandar, S. Budania, J. Jaipuria.
Intra-abdominal pressure in acute pancreatitis: canary in coal mine?; result after a rigorous validation protocol.
Gastroenterology, 142 (2012), pp. S1058
[22.]
B.U. Wu, J.Q. Hwang, T.H. Gardner, K. Repas, R. Delee, S. Yu, et al.
Lactated Ringer's solution reduces systemic inflammation compared with saline in patients with acute pancreatitis.
Clin Gastroenterol Hepatol, 9 (2011), pp. 710-717
[23.]
E.Q. Mao, Y.Q. Tang, J. Fei, S. Qin, J. Wu, L. Li, et al.
Fluid therapy for severe acute pancreatitis in acute response stage.
Chin Med J (Engl), 122 (2009), pp. 169-173
[24.]
E. De-Madaria, G. Soler-Sala, J. Sánchez-Paya, I. López-Font, J. Martínez, L. Gómez-Escolar, et al.
Influence of fluid therapy on the prognosis of acute pancreatitis: a prospective cohort study.
Am J Gastroenterol, 106 (2011), pp. 1843-1850
[25.]
M. Petrov, A. Phillips, J.A. Windsor.
Early nasogastric tube feeding versus nil-by-mouth in patients with mild and moderate acute pancreatitis: a randomized controlled trial.
Gastroenterology, 142 (2012), pp. S94
[26.]
R. Wang, F. Yang, H. Wu, Y.F. Wang, B. Hu, M.G. Zhang, et al.
Octreotide at high dose in the treatment of acute pancreatitis: a prospective randomized controlled trial.
Gastroenterology, 142 (2012), pp. S62
Copyright © 2012. Elsevier España, S.L.. Todos los derechos reservados
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