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Inicio Gastroenterología y Hepatología (English Edition) Diagnostic accuracy of multitarget stool DNA testing for colorectal cancer scree...
Journal Information
Vol. 45. Issue 10.
Pages 753-766 (December 2022)
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Vol. 45. Issue 10.
Pages 753-766 (December 2022)
Original article
Diagnostic accuracy of multitarget stool DNA testing for colorectal cancer screening: A systematic review and meta-analysis
Precisión diagnóstica de las pruebas de DNA en heces con objetivos múltiples para la detección del cáncer colorrectal: una revisión sistemática y un metaanálisis
Roya Dolatkhaha,
Corresponding author
royadolatkhah@yahoo.com

Corresponding authors.
, Saeed Dastgirib, Mohammad Asghari Jafarabadic,d,e, Hossein Mashhadi Abdolahif, Mohammad Hossein Somig,
Corresponding author
mhosseinsina@yahoo.com

Corresponding authors.
a Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
b Tabriz Health Services Management Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
c Cabrini Research, Cabrini Health, Australia
d School of Public Health and Preventative Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Australia
e Road and Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
f Tabriz Health Services Management Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
g Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Article information
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Abstract
Introduction

This study aimed to collect and summarize test data and conduct a meta-analysis, with respect to the Multitarget Stool DNA test sensitivity and specificity, compared to colonoscopy.

Material and methods

All manuscripts were screened for eligibility according to inclusion criteria. Participants were a normal population at an average risk of developing CRC. Intervention was Stool based and DNA panel tests compared with colonoscopy, and outcome was detection of CRC and any pre-cancerous lesions. Inter-study and inconsistency (using the I-squared test) were assessed.

Results

Meta-analyses of the Mt-sDNA test showed a combined sensitivity of 89%, 51%, and 76% for the detection of CRC, advanced adenoma (AA), and combined CRC and AA, respectively. The overall specificity was 91%, 89%, and 90% for the detection of CRC, AA, and combined CRC and AA, respectively.

Conclusion

Mt-sDNA had significantly acceptable diagnostic accuracy for CRC and AA diagnosis, but still has lower sensitivity and specificity than colonoscopy.

Keywords:
Colorectal cancer
Screening
Accuracy
Multitarget
Stool test
Resumen
Introducción

Este estudio tuvo como objetivo recopilar y resumir los datos de las pruebas y realizar un metaanálisis con respecto a la sensibilidad y especificidad de la prueba de DNA en heces multiobjetivo, en comparación con la colonoscopia.

Material y métodos

Todos los manuscritos fueron examinados para determinar su elegibilidad de acuerdo con los criterios de inclusión. Los participantes eran una población normal con un riesgo promedio de desarrollar CRC. La intervención se basó en heces y pruebas de panel de DNA en comparación con la colonoscopia, y el resultado fue la detección de CRC y cualquier lesión precancerosa. Se evaluaron la inconsistencia entre estudios y la inconsistencia (mediante la prueba de I cuadrado).

Resultados

Los metaanálisis de la prueba Mt-sDNA mostraron una sensibilidad combinada del 89%, 51% y 76% para la detección de CRC, adenoma avanzado (AA) y CRC y AA combinados, respectivamente. La especificidad general fue del 91%, 89% y 90% para la detección de CRC, AA y CRC y AA combinados, respectivamente.

Conclusión

Mt-sDNA tuvo una precisión diagnóstica significativamente aceptable para el diagnóstico de CRC y AA, pero aún tiene una sensibilidad y especificidad más bajas que la colonoscopia.

Palabras clave:
Cáncer colorrectal
Poner en pantalla
Exactitud
Multiobjetivo
Prueba de heces

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