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Gastrointestinal and hepatobiliary manifestations in patients with common variable immunodeficiency: In relation to three clinical cases
Manifestaciones gastrointestinales y hepatobiliares en pacientes con inmunodeficiencia común variable: a propósito de 3 casos clínicos
César Naveaa, Matías Echeverríab, César Romerob, Emily Osseb, Javier Brahma, Jaime Poniachika,
Corresponding author
jaime_poniachik@yahoo.es

Corresponding author.
a Sección de Gastroenterología, Hospital Clínico Universidad de Chile, Santiago, Chile
b Facultad de Medicina, Universidad de Chile, Santiago, Chile
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Common variable immunodeficiency &#40;CVID&#41; is a primary immune condition characterised by immunoglobulin deficiency&#46; This leads to recurrent infections and&#44; less commonly&#44; autoimmune or skin manifestations&#44; as well as a higher risk of cancer&#44; particularly gastrointestinal and haematological types&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> CVID affects one in 50&#44;000&#44; predominantly young people&#44; and has no relationship with gender or race&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Diagnosis is based on low IgG&#44; reduction of at least one of the IgM or IgA isotypes and meeting three criteria&#58; onset of immunodeficiency after the age of two&#59; absence of isohaemagglutinins and poor response to vaccines&#59; and exclusion of other causes of hypogammaglobulinaemia&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> CVID presents with gastrointestinal symptoms in up to 60&#37; of cases<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> and hepatic symptoms in 10&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">We present three cases of patients with CVID and gastrointestinal symptoms&#46; The first was a 46-year-old male who&#44; in the context of acute hepatitis&#44; had a liver biopsy which showed autoimmune hepatitis &#40;AIH&#41;&#46; He was managed with prednisone plus azathioprine with a good response&#46; Blood tests revealed low immunoglobulins&#44; but no previous recurrent infections&#46; During follow-up&#44; CVID was diagnosed&#46; He is managed with monthly immunoglobulin replacement with a good clinical response&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The next case is that of a 33-year-old male patient with a history of CVID and recurrent respiratory infections&#44; on therapy with monthly doses of immunoglobulin&#46; Blood tests over the last 12 months showed a progressive decrease in total proteins &#40;4&#46;6<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; and albumin &#40;2&#46;9<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;&#46; He had normal prealbumin&#44; no proteinuria&#44; negative anti-transglutaminase antibodies and no weight loss&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Upper endoscopy showed antrum erosions&#44; and colonoscopy resected colon polyps&#46; Biopsies of the small intestine showed chronic duodenitis with subtotal villous atrophy and colon polyps with high-grade dysplasia&#46; Nutrition was optimised without response&#44; and protein-losing enteropathy was suspected and confirmed with the measurement of &#945;1-antitrypsin in stools&#46; The patient responded well to treatment with corticosteroids&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The last case is that of a 21-year-old male with a history of CVID and cyclic neutropenia&#44; with recurrent infections&#44; who occasionally receives doses of immunoglobulins&#46; In the context of pruritus and abnormal liver function tests&#44; primary sclerosing cholangitis &#40;PSC&#41; was diagnosed by magnetic resonance cholangiography&#46; Secondary causes were ruled out and treatment was started with ursodeoxycholic acid&#44; with a good response&#46; The patient later presented with a six month history of intermittent diarrhoea with blood&#44; but no other symptoms&#46; Laboratory tests showed anaemia&#44; neutropenia and normal faecal calprotectin&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Colonoscopy showed non-specific proctitis and two sigmoid polyps&#44; which were resected&#46; Biopsies showed non-specific chronic colitis&#46; Immunoglobulins were prescribed monthly&#44; improving the diarrhoea&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">CVID is the most common primary immunodeficiency characterised by B cell dysfunction and low antibody production&#44; leading to a poor response to infections and vaccines&#46; In addition&#44; dysregulation of T cell function is described&#44; which determines some of the autoimmune manifestations&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The first case has AIH&#59; autoimmunity is common in CVID and autoimmune reactions have been described in the liver&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> The diagnosis is complex&#44; as IgG does not rise&#46; In this case the Hennes criteria were applied for diagnosis&#44; with the patient scoring a total of six points&#46; Patients with CVID have a higher incidence of liver granulomas&#44; nodular regenerative hyperplasia&#44; PSC&#44; primary biliary cholangitis and cryptogenic cirrhosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#8211;5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The second case had hypoalbuminaemia and mononuclear inflammatory infiltration of the duodenal mucosa&#46; In CVID&#44; lymphocytic infiltration in the gastrointestinal tract is common&#44;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> resembling an autoimmune enteropathy&#44; such as coeliac disease&#44; which causes malabsorption&#44; and this would explain the hypoalbuminaemia&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> In these cases&#44; anti-transglutaminase antibodies are negative and there is no response to a gluten-free diet&#59; selected cases respond to corticosteroids&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> The patient had several colon polyps&#46; The presence of colon polyps is similar to the general population and there is no increased risk of colon cancer&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The third patient presented with chronic diarrhoea and inflammatory involvement of the colorectal mucosa&#46; Inflammatory bowel disease is more common in patients with CVID&#44; but the detection of non-specific colitis is common and would explain the diarrhoea&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> Immunoglobulin replacement does not generally resolve these symptoms&#44; so corticosteroid therapy is required&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> He also has PSC&#44; which is more common in patients with CVID&#46; Other gastrointestinal tract disorders include opportunistic infections that would cause chronic diarrhoea and <span class="elsevierStyleItalic">Helicobacter pylori</span> infection&#44; associated with a 50-fold increase in the incidence of gastric cancer compared to the general population&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Last of all&#44; gastrointestinal and hepatobiliary manifestations are common in patients with CVID&#44; 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