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array:23 [ "pii" => "S244438242030002X" "issn" => "24443824" "doi" => "10.1016/j.gastre.2019.09.007" "estado" => "S300" "fechaPublicacion" => "2020-02-01" "aid" => "1447" "copyrightAnyo" => "2020" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Gastroenterol Hepatol. 2020;43:87-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:18 [ "pii" => "S0210570519302158" "issn" => "02105705" "doi" => "10.1016/j.gastrohep.2019.09.003" "estado" => "S300" "fechaPublicacion" => "2020-02-01" "aid" => "1447" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Gastroenterol Hepatol. 2020;43:87-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 72 "formatos" => array:2 [ "HTML" => 49 "PDF" => 23 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta científica</span>" "titulo" => "Tumor neuroendocrino de la vesícula biliar" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "87" "paginaFinal" => "88" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Neuroendocrine tumour of the gallbladder" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 393 "Ancho" => 1264 "Tamanyo" => 226251 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A) El tumor crece por debajo del epitelio de superficie formando pequeños nidos y trabéculas. Las células son de tamaño uniforme, con citoplasma ligeramente eosinófilo y núcleo ovoideo, sin atipia significativa (H&E). B) Tinción de inmunohistoquímica para cromogranina: se observa una positividad citoplasmática intensa en las células neoplásicas.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Joana Aylhin López Marcano, José Manuel Ramia Ángel, Roberto de la Plaza Llamas, Alba Manuel Vázquez, Raquel Latorre Fragua" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Joana Aylhin" "apellidos" => "López Marcano" ] 1 => array:2 [ "nombre" => "José Manuel" "apellidos" => "Ramia Ángel" ] 2 => array:2 [ "nombre" => "Roberto" "apellidos" => "de la Plaza Llamas" ] 3 => array:2 [ "nombre" => "Alba" "apellidos" => "Manuel Vázquez" ] 4 => array:2 [ "nombre" => "Raquel" "apellidos" => "Latorre Fragua" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S244438242030002X" "doi" => "10.1016/j.gastre.2019.09.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S244438242030002X?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570519302158?idApp=UINPBA00004N" "url" => "/02105705/0000004300000002/v2_202002170616/S0210570519302158/v2_202002170616/es/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S2444382420300018" "issn" => "24443824" "doi" => "10.1016/j.gastre.2019.09.006" "estado" => "S300" "fechaPublicacion" => "2020-02-01" "aid" => "1448" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Gastroenterol Hepatol. 2020;43:88-90" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>" "titulo" => "Endoscopic submucosal dissection for localised gastric amyloidosis mimicking malignancy" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "88" "paginaFinal" => "90" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Disección submucosa endoscópica para la amiloidosis localizada gástrica que simula una malignidad" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 753 "Ancho" => 1750 "Tamanyo" => 223882 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) EGD showed the flat depressed lesion in the stomach. (B) EUS revealed the first layer was thinned and the second layer was thickened. (C) NBI+ME showed the mucosal pit pattern and microvessels were obviously changed. (D) Apple green birefringence of amyloid deposition under polarized light. (E) Endoscopic submucosal dissection. (F,G,H) EGD revealed a scar formation and NBI+ME showed sparse glandular tube structure in 3 months and 1 years after surgery.</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">EGD, Esophagogastroduodenoscopy; EUS, Endoscopy ultrasound evaluation; NBI+ME, Narrow-band imaging with magnified endoscopy.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Tao Yang, Jia-Wei Lu, Li-Hong Teng, Jing-Jing Feng, Jia-Guo Wu, Wei-Li Liu" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Tao" "apellidos" => "Yang" ] 1 => array:2 [ "nombre" => "Jia-Wei" "apellidos" => "Lu" ] 2 => array:2 [ "nombre" => "Li-Hong" "apellidos" => "Teng" ] 3 => array:2 [ "nombre" => "Jing-Jing" "apellidos" => "Feng" ] 4 => array:2 [ "nombre" => "Jia-Guo" "apellidos" => "Wu" ] 5 => array:2 [ "nombre" => "Wei-Li" "apellidos" => "Liu" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S021057051930216X" "doi" => "10.1016/j.gastrohep.2019.09.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021057051930216X?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444382420300018?idApp=UINPBA00004N" "url" => "/24443824/0000004300000002/v1_202002111756/S2444382420300018/v1_202002111756/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2444382420300109" "issn" => "24443824" "doi" => "10.1016/j.gastre.2019.08.008" "estado" => "S300" "fechaPublicacion" => "2020-02-01" "aid" => "1453" "copyright" => "Elsevier España, S.L.U." 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The cells are of uniform size, with slightly eosinophilic cytoplasm and an ovoid nucleus, with no significant atypia (H&E). B) Immunohistochemical staining for chromogranin: intense cytoplasmic positivity is seen in the neoplastic cells.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Neuroendocrine tumours (NETs) are a heterogeneous group of neoplasms that originate from neuroendocrine system cells, primarily located in the gastrointestinal tract and the lung.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">NETs of the gall bladder (NET-GB) are very uncommon: they account for only 2.1% of all gall bladder tumours and are often an incidental finding during the histopathological examination of the gall bladder following a cholecystectomy.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">We present two cases of NET-GB and discuss the symptoms, diagnosis and treatment of these uncommon tumours.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Case 1: 51-year-old woman with a history of biliary colic. The ultrasound showed cholelithiasis; the blood tests showed no abnormal values. A scheduled laparoscopic cholecystectomy was performed and she was discharged after 24 h with no complications. The histological study showed low-grade 1.6 × 0.7 cm NET, G1, Ki67 1%, with positive chromogranin and cystic node with no signs of malignancy. The CT of the chest and abdomen showed no signs of distant metastases. The chromogranin A figure was <5 ng/ml. There were no signs of recurrence in the annual follow-up at three years with CT and chromogranin.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Case 2: 50-year-old male with a history of type 2 diabetes mellitus, hepatitis C virus infection and schizophrenia, in whom an ultrasound showed a large 1 cm polyp in the gall bladder; the blood tests showed no abnormal values. A scheduled laparoscopic cholecystectomy was performed and he was discharged after 24 h with no complications. The histopathological study showed low grade NET, G1, microcarcinoid, with polyp-like configuration, measuring 3.5 mm, limited to mucosa, Ki67 1.2%, with positive chromogranin and no involvement of the pericystic lymph node (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The CT of the chest and abdomen showed no signs of distant spread. The chromogranin A figure was 130 ng/ml. There were no signs of recurrence in the annual follow-up at two years with CT and chromogranin.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">NET-GB account for 0.5% of all NETs and are more common in women (68%). The age of onset varies from 26 to 79 years.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">There are two theories regarding the origin of NET-GB. One postulates that they could originate from multipotent stem cells, ectopic pancreatic tissue or nerve fibres located in the wall of the gallbladder, while the other proposes that they originate from neuroendocrine cells (enterochromaffin or Kulchitsky cells) in the intestinal or gastric metaplasia of the gallbladder epithelium, produced after chronic inflammation caused by cholelithiasis.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Non-functioning NETs are indolent, generally give rise to symptoms derived from the mass effect such as abdominal pain and jaundice. They tend to be diagnosed in advanced stages, with metastasis in approximately 40% of all cases.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Functioning NETs can cause a wide range of signs and symptoms due to hormonal hyperactivity. Carcinoid syndrome, characterised by flushing, hypotension, diarrhoea, wheezing and heart disease caused by serotonin, has been reported in less than 1% of cases of NET-GB.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">NET-GB is rarely diagnosed pre-operatively. By extrapolation of NETs of the digestive tract and pancreas, for NETs the cancer staging manual (version 3.2018) of the American Joint Committee on Cancer recommends CT or MRI and, as appropriate, images based on somatostatin receptors (preferably PET or scintigraphy), CT of the chest and serum chromogranin or 5-HIAA in urine.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In NET-GB, however, the diagnosis is usually incidental from the histopathological study and the immunohistochemical staining of a surgical specimen taken from a cholecystectomy scheduled due to cholelithiasis or cholecystitis, and only studied by abdominal ultrasound.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> These two cases were only identified in the histopathological study after cholecystectomies indicated for cholelithiasis. The histological diagnosis should include morphology (large versus small cells and differentiation), staining for chromogranin A and synaptophysin, Ki-67 and mitotic count. This facilitates their classification as: low grade, differentiated (G1, Ki-67 index <3%); intermediate grade, moderately differentiated (G2, Ki-67 index ≥3% and ≤20%); poorly differentiated high grade neoplasms (G3, Ki-67 index >20%), small or large cell.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The most commonly used serum marker is chromogranin A, secreted by neuronal and neuroendocrine cells. It can be elevated in patients with kidney or liver failure and in patients treated with proton pump inhibitors.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Chromogranin B, neuron-specific enolase and quantification of 5-HIAA in urine can also be useful.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> They should only be used to support the diagnosis and as indicators of tumour burden and response to treatment.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Resection is the primary treatment approach.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Cholecystectomy is usually sufficient if the cystic node is negative and there is a free margin; otherwise, the surgery should be extended<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and more intensive treatment considered, based on regional lymphadenectomy or IVb-V bisegmentectomy. Adjuvant therapy is recommended in patients with a Ki-67 value of >20–55%, which is more effective for the small cell subtype. Specific prognostic factors have not been identified in NET-GB, but the proliferative index, differentiation and tumour size are global prognostic factors.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,4</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">According to the NCCN Guidelines, serum chromogranin or 5-HIAA in urine should be analysed and a CT or MRI should be performed between three and 12 months post-resection and every 12–24 months.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The five-year survival rates for advanced disease are currently 77–95% when treated with primary tumour resection and adjuvant therapy. However, more aggressive subtypes have been reported, with a fast clinical course in which survival and prognosis are considerably worse.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">In conclusion, NET-GB are uncommon and generally non-functioning. They tend to be diagnosed in the histopathological study of the gallbladder after cholecystectomy due to cholelithiasis. The cystic node should be studied to decide whether to use the lymphadenectomy or IVb-V bisegmentectomy approach and adjuvant therapy should be considered based on the proliferative index.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: López Marcano JA, Ramia Ángel JM, de la Plaza Llamas R, Manuel Vázquez A, Latorre Fragua R. Tumor neuroendocrino de la vesícula biliar. Gastroenterol Hepatol. 2020;43:87–88.</p>" ] ] "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 557 "Ancho" => 1800 "Tamanyo" => 375205 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A) The tumour grows beneath the surface epithelium, forming small nests and trabeculae. The cells are of uniform size, with slightly eosinophilic cytoplasm and an ovoid nucleus, with no significant atypia (H&E). 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