metricas
covid
Buscar en
Gastroenterología y Hepatología (English Edition)
Toda la web
Inicio Gastroenterología y Hepatología (English Edition) Hepatic tuberculosis mimicking metastatic colorectal cancer
Journal Information

Statistics

Follow this link to access the full text of the article

Scientific letter
Hepatic tuberculosis mimicking metastatic colorectal cancer
Tuberculosis hepática simulando metástasis de cáncer colorrectal
Iván Carmelo Soto-Darias
Corresponding author
ivansd89@hotmail.com

Corresponding author.
, Alejandro Morales-Hernández, Ángel García-Romera, Alberto Bravo-Gutiérrez, Antonio Alarcó-Hernández
Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario de Canarias, San Cristóbal de la Laguna, Santa Cruz de Tenerife, Spain
Read
1312
Times
was read the article
175
Total PDF
1137
Total HTML
Share statistics
 array:23 [
  "pii" => "S2444382420300031"
  "issn" => "24443824"
  "doi" => "10.1016/j.gastre.2019.08.006"
  "estado" => "S300"
  "fechaPublicacion" => "2020-02-01"
  "aid" => "1451"
  "copyrightAnyo" => "2020"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Gastroenterol Hepatol. 2020;43:90-1"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "es" => array:18 [
      "pii" => "S0210570519302195"
      "issn" => "02105705"
      "doi" => "10.1016/j.gastrohep.2019.08.010"
      "estado" => "S300"
      "fechaPublicacion" => "2020-02-01"
      "aid" => "1451"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Gastroenterol Hepatol. 2020;43:90-1"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:2 [
        "total" => 99
        "formatos" => array:2 [
          "HTML" => 60
          "PDF" => 39
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fica</span>"
        "titulo" => "Tuberculosis hep&#225;tica simulando met&#225;stasis de c&#225;ncer colorrectal"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "90"
            "paginaFinal" => "91"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Hepatic tuberculosis mimicking metastatic colorectal cancer"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 638
                "Ancho" => 1750
                "Tamanyo" => 110071
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#41; En la TAC se observa una lesi&#243;n hipodensa en el l&#243;bulo hep&#225;tico derecho&#46; B&#41; Lesiones hiperintensas en T1 bilobares en la RMN&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Iv&#225;n Carmelo Soto-Darias, Alejandro Morales-Hern&#225;ndez, &#193;ngel Garc&#237;a-Romera, Alberto Bravo-Guti&#233;rrez, Antonio Alarc&#243;-Hern&#225;ndez"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "Iv&#225;n Carmelo"
                "apellidos" => "Soto-Darias"
              ]
              1 => array:2 [
                "nombre" => "Alejandro"
                "apellidos" => "Morales-Hern&#225;ndez"
              ]
              2 => array:2 [
                "nombre" => "&#193;ngel"
                "apellidos" => "Garc&#237;a-Romera"
              ]
              3 => array:2 [
                "nombre" => "Alberto"
                "apellidos" => "Bravo-Guti&#233;rrez"
              ]
              4 => array:2 [
                "nombre" => "Antonio"
                "apellidos" => "Alarc&#243;-Hern&#225;ndez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2444382420300031"
          "doi" => "10.1016/j.gastre.2019.08.006"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444382420300031?idApp=UINPBA00004N"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570519302195?idApp=UINPBA00004N"
      "url" => "/02105705/0000004300000002/v2_202002170616/S0210570519302195/v2_202002170616/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2444382420300043"
    "issn" => "24443824"
    "doi" => "10.1016/j.gastre.2019.09.008"
    "estado" => "S300"
    "fechaPublicacion" => "2020-02-01"
    "aid" => "1457"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46;"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Gastroenterol Hepatol. 2020;43:92-3"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>"
      "titulo" => "Massive proteinuria for minimal change nephropathy secondary to treatment with D-penicillamine in a patient with Wilson&#8217;s disease&#46; Case report"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "92"
          "paginaFinal" => "93"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Proteinuria masiva por nefropat&#237;a por cambios m&#237;nimos secundaria a tratamiento con D-penicilamina en un paciente con enfermedad de Wilson hep&#225;tica&#46; A prop&#243;sito de un caso"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Elena Borrego Garc&#237;a, Elena Hern&#225;ndez Garc&#237;a, Mercedes Caba Molina, Antonio Mar&#237;a Navas-Parejo Casado"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Elena"
              "apellidos" => "Borrego Garc&#237;a"
            ]
            1 => array:2 [
              "nombre" => "Elena"
              "apellidos" => "Hern&#225;ndez Garc&#237;a"
            ]
            2 => array:2 [
              "nombre" => "Mercedes"
              "apellidos" => "Caba Molina"
            ]
            3 => array:2 [
              "nombre" => "Antonio Mar&#237;a"
              "apellidos" => "Navas-Parejo Casado"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S021057051930250X"
        "doi" => "10.1016/j.gastrohep.2019.09.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021057051930250X?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444382420300043?idApp=UINPBA00004N"
    "url" => "/24443824/0000004300000002/v1_202002111756/S2444382420300043/v1_202002111756/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S2444382420300018"
    "issn" => "24443824"
    "doi" => "10.1016/j.gastre.2019.09.006"
    "estado" => "S300"
    "fechaPublicacion" => "2020-02-01"
    "aid" => "1448"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Gastroenterol Hepatol. 2020;43:88-90"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>"
      "titulo" => "Endoscopic submucosal dissection for localised gastric amyloidosis mimicking malignancy"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "88"
          "paginaFinal" => "90"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Disecci&#243;n submucosa endosc&#243;pica para la amiloidosis localizada g&#225;strica que simula una malignidad"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 753
              "Ancho" => 1750
              "Tamanyo" => 223882
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; EGD showed the flat depressed lesion in the stomach&#46; &#40;B&#41; EUS revealed the first layer was thinned and the second layer was thickened&#46; &#40;C&#41; NBI&#43;ME showed the mucosal pit pattern and microvessels were obviously changed&#46; &#40;D&#41; Apple green birefringence of amyloid deposition under polarized light&#46; &#40;E&#41; Endoscopic submucosal dissection&#46; &#40;F&#44;G&#44;H&#41; EGD revealed a scar formation and NBI&#43;ME showed sparse glandular tube structure in 3 months and 1 years after surgery&#46;</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">EGD&#44; Esophagogastroduodenoscopy&#59; EUS&#44; Endoscopy ultrasound evaluation&#59; NBI&#43;ME&#44; Narrow-band imaging with magnified endoscopy&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Tao Yang, Jia-Wei Lu, Li-Hong Teng, Jing-Jing Feng, Jia-Guo Wu, Wei-Li Liu"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Tao"
              "apellidos" => "Yang"
            ]
            1 => array:2 [
              "nombre" => "Jia-Wei"
              "apellidos" => "Lu"
            ]
            2 => array:2 [
              "nombre" => "Li-Hong"
              "apellidos" => "Teng"
            ]
            3 => array:2 [
              "nombre" => "Jing-Jing"
              "apellidos" => "Feng"
            ]
            4 => array:2 [
              "nombre" => "Jia-Guo"
              "apellidos" => "Wu"
            ]
            5 => array:2 [
              "nombre" => "Wei-Li"
              "apellidos" => "Liu"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S021057051930216X"
        "doi" => "10.1016/j.gastrohep.2019.09.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021057051930216X?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444382420300018?idApp=UINPBA00004N"
    "url" => "/24443824/0000004300000002/v1_202002111756/S2444382420300018/v1_202002111756/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>"
    "titulo" => "Hepatic tuberculosis mimicking metastatic colorectal cancer"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "90"
        "paginaFinal" => "91"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Iv&#225;n Carmelo Soto-Darias, Alejandro Morales-Hern&#225;ndez, &#193;ngel Garc&#237;a-Romera, Alberto Bravo-Guti&#233;rrez, Antonio Alarc&#243;-Hern&#225;ndez"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "Iv&#225;n Carmelo"
            "apellidos" => "Soto-Darias"
            "email" => array:1 [
              0 => "ivansd89@hotmail.com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "Alejandro"
            "apellidos" => "Morales-Hern&#225;ndez"
          ]
          2 => array:2 [
            "nombre" => "&#193;ngel"
            "apellidos" => "Garc&#237;a-Romera"
          ]
          3 => array:2 [
            "nombre" => "Alberto"
            "apellidos" => "Bravo-Guti&#233;rrez"
          ]
          4 => array:2 [
            "nombre" => "Antonio"
            "apellidos" => "Alarc&#243;-Hern&#225;ndez"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Cirug&#237;a General y del Aparato Digestivo&#44; Hospital Universitario de Canarias&#44; San Crist&#243;bal de la Laguna&#44; Santa Cruz de Tenerife&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Tuberculosis hepa&#769;tica simulando meta&#769;stasis de ca&#769;ncer colorrectal"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 638
            "Ancho" => 1749
            "Tamanyo" => 109991
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#41; The CT shows a hypodense lesion in the right lobe of the liver&#46; B&#41; Bilobar hyperintense lesions in T1 on the MRI&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Tuberculosis is an infectious disease caused by <span class="elsevierStyleItalic">Mycobacterium tuberculosis complex</span>&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> the target organs of which are the lungs&#46; It primarily affects the populations of developing areas&#44; causing 2&#44;000&#44;000 deaths per year&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Extrapulmonary tuberculosis is derived from the pulmonary disease and primarily affects immunosuppressed individuals&#44; particularly HIV patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a> The most commonly affected extrapulmonary tissues are the pleura&#44; the lymph nodes and the urinary system&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The rarity of liver involvement coupled with its nonspecific symptoms make it difficult to diagnose&#44; meaning that histological confirmation is often required&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2&#44;4</span></a> As in our case&#44; it can be confused with primary or metastatic liver tumours&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 69-year-old male with a history of smoking and alcoholism&#44; diabetes mellitus&#44; hypertension&#44; dyslipidaemia and a rectal adenocarcinoma in 2013 who received neoadjuvant chemotherapy and radiotherapy&#44; followed by surgery with a pathological finding of T3N0M0&#44; receiving adjuvant therapy with six cycles of Xeloda&#174;&#46; The patient subsequently remained free of clinical and radiological disease and&#44; at the fourth year of follow-up&#44; exhibited a hypodense low attenuation lesion on the CT scan &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41; in segment VI of the liver&#46; Given his oncological history&#44; liver metastasis of colorectal origin was the first possibility to be considered&#46; The study was extended with an abdominal ultrasound&#44; which revealed multiple nodular lesions measuring up to 2&#8239;cm in diameter&#44; and an MRI &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#44; which showed hyperintense&#44; non-calcified bilobar lesions in T1 Fat-Sat with contrast in arterial phase&#44; in segments II&#44; <span class="elsevierStyleSmallCaps">iv</span>A&#44; <span class="elsevierStyleSmallCaps">iv</span>B&#44; VIII and VI&#44; all suggestive of liver metastases&#44; and CEA at the upper limit of normal&#46; The case was submitted to the digestive tumour committee&#44; and it was decided to start systemic chemotherapy with six cycles of FOLFIRI plus cetuximab&#46; New CT and MRI scans at four months showed partial response to chemotherapy with a reduction in the size of the hepatic space-occupying lesions &#40;SOLs&#41;&#44; except for one in segment II and one in segment VI&#46; It was decided to perform rescue surgery on the liver&#44; finding five subcapsular lesions suggestive of subcentimetric metastases in segments <span class="elsevierStyleSmallCaps">iv</span>A&#44; <span class="elsevierStyleSmallCaps">iv</span>B&#44; V&#44; VI and VIII&#44; as well as two intraparenchymatous lesions in segments II and <span class="elsevierStyleSmallCaps">iv</span>B&#46; Metastasectomy of the subcapsular lesions was performed and microwaves were applied to the intraparenchymatous lesions&#46; The histological result of all the samples showed granulomatous nodular lesions centred by necrosis of a caseous appearance surrounded by epithelioid histiocytes&#44; some multinucleated giant cells and&#44; peripherally&#44; fibrosis with Ziehl-Neelsen staining&#59; no acid-alcohol-resistant bacilli were detected&#46; Neoplastic cells were not found in any of the samples&#46; The patient was assessed by the Infectious Diseases department and started treatment with isoniazid&#44; rifampicin and pyrazinamide for nine months with good drug tolerance&#46; At the end of treatment&#44; a CT scan and MRI showed complete resolution of the described lesions&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Hepatic tuberculosis is an uncommon form of tuberculosis&#44; accounting for 1&#37; of all cases of abdominal tuberculosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> It can present as disseminated tuberculosis with synchronous pulmonary involvement&#44; diffuse liver involvement without pulmonary disease&#44; or in the form of a solitary liver abscess or tuberculoma&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> The low incidence of primary hepatic tuberculosis is related to low oxygen levels in hepatocytes&#44; meaning that this tissue does not provide a favourable environment for <span class="elsevierStyleItalic">Mycobacterium tuberculosis&#46;</span><a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The first reference in the literature to hepatic tuberculosis was made by Bristowe in 1858&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> It can clinically manifest with nonspecific symptoms such as fever&#44; abdominal pain&#44; weight loss&#44; hepatomegaly or even abnormal liver function tests<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> or&#44; as in our patient&#44; an incidental finding in a histological study expected to show metastasis of colorectal origin&#46; Its diagnosis is complex and highly specific but it is uncommon to find Koch&#39;s bacillus in histological material&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Given the nonspecificity of the characteristics of imaging tests&#44; it can be mistaken radiologically for primary or secondary liver tumours&#44; as in our case&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;5</span></a> Once diagnosed&#44; the objective is to start tuberculosis treatment as soon as possible&#44; achieving resolution of the lesions in 6&#8211;12 months&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In conclusion&#44; although tuberculosis is now uncommon in our setting&#44; and extrapulmonary tuberculosis even more so&#44; it should be considered in the differential diagnosis of primary or secondary liver tumours in patients with a history of cancer&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0025" class="elsevierStylePara elsevierViewall">This study was conducted without a grant&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Funding"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Soto-Darias IC&#44; Morales-Hern&#225;ndez A&#44; Garc&#237;a-Romera &#193;&#44; Bravo-Guti&#233;rrez A&#44; Alarc&#243;-Hern&#225;ndez A&#46; Tuberculosis hepa&#769;tica simulando meta&#769;stasis de ca&#769;ncer colorrectal&#46; Gastroenterol Hepatol&#46; 2020&#59;43&#58;90&#8211;91&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 638
            "Ancho" => 1749
            "Tamanyo" => 109991
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#41; The CT shows a hypodense lesion in the right lobe of the liver&#46; B&#41; Bilobar hyperintense lesions in T1 on the MRI&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acerca de la tuberculosis extrapulmonar"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46; Chaves"
                            1 => "J&#46;F&#46; Buitrago"
                            2 => "A&#46; Due&#241;as"
                            3 => "J&#46;C&#46; Bejarano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.reper.2017.04.004"
                      "Revista" => array:5 [
                        "tituloSerie" => "Repert Med y Cirug&#237;a"
                        "fecha" => "2017"
                        "volumen" => "26"
                        "paginaInicial" => "90"
                        "paginaFinal" => "97"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hepatic tuberculoma simulating metastasis of gastric neuroendocrine carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;F&#46; Anduaga-Pe&#241;a"
                            1 => "J&#46;E&#46; Qui&#241;ones-Sampedro"
                            2 => "M&#46;J&#46; Iglesias-Iglesias"
                            3 => "M&#46;J&#46; Servide-Staffolani"
                            4 => "L&#46;M&#46; Gonz&#225;lez-Fern&#225;ndez"
                            5 => "M&#46;C&#46; Esteban-Velasco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.30944/20117582.76.3"
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Colomb Cir&#46;"
                        "fecha" => "2018"
                        "volumen" => "33"
                        "paginaInicial" => "307"
                        "paginaFinal" => "310"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extra-pulmonary tuberculosis&#58; a retrospective study of patients in Accra&#44; Ghana"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46;A&#46; Ohene"
                            1 => "M&#46;I&#46; Bakker"
                            2 => "J&#46; Ojo"
                            3 => "A&#46; Toonstra"
                            4 => "D&#46; Awudi"
                            5 => "P&#46; Klatser"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.7910/DVN/TA1OII/ZSVFGO"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS One"
                        "fecha" => "2019"
                        "volumen" => "14"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31891643"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0025775303739530"
                          "estado" => "S300"
                          "issn" => "00257753"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary hepatic tuberculosis masquerading as cholangiocarcinoma&#58; a clinical nugget"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "I&#46;A&#46; Shera"
                            1 => "M&#46;R&#46; Shawl"
                            2 => "P&#46; Rajan"
                            3 => "R&#46;C&#46; Soni"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5152/tjg.2018.18558"
                      "Revista" => array:5 [
                        "tituloSerie" => "Turkish J Gastroenterol"
                        "fecha" => "2019"
                        "volumen" => "30"
                        "paginaInicial" => "764"
                        "paginaFinal" => "766"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnosis of local hepatic tuberculosis through next-generation sequencing&#58; smarter&#44; faster and better"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;W&#46; Ai"
                            1 => "Y&#46; Li"
                            2 => "Q&#46; Cheng"
                            3 => "P&#46; Cui"
                            4 => "H&#46;L&#46; Wu"
                            5 => "B&#46; Xu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clinre.2018.04.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Res Hepatol Gastroenterol"
                        "fecha" => "2018"
                        "volumen" => "42"
                        "paginaInicial" => "178"
                        "paginaFinal" => "181"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29759945"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/24443824/0000004300000002/v1_202002111756/S2444382420300031/v1_202002111756/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "77930"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Scientific letter"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/24443824/0000004300000002/v1_202002111756/S2444382420300031/v1_202002111756/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444382420300031?idApp=UINPBA00004N"
]
Article information
ISSN: 24443824
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 4 0 4
2024 October 27 7 34
2024 September 40 17 57
2024 August 27 14 41
2024 July 17 3 20
2024 June 22 1 23
2024 May 30 2 32
2024 April 18 6 24
2024 March 37 8 45
2024 February 44 1 45
2024 January 31 3 34
2023 December 52 6 58
2023 November 44 6 50
2023 October 69 1 70
2023 September 38 1 39
2023 August 49 3 52
2023 July 35 7 42
2023 June 43 2 45
2023 May 105 2 107
2023 April 47 1 48
2023 March 51 4 55
2023 February 40 4 44
2023 January 23 3 26
2022 December 24 2 26
2022 November 26 6 32
2022 October 25 9 34
2022 September 52 5 57
2022 August 21 10 31
2022 July 13 10 23
2022 June 13 11 24
2022 May 14 6 20
2022 April 19 5 24
2022 March 15 6 21
2022 February 22 3 25
Show all

Follow this link to access the full text of the article

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos