Scientific letter
Perianal disease as the first manifestation in paediatric Crohn's disease
Enfermedad perianal como primera manifestación en la enfermedad de Crohn pediátrica
Albany María Sosa Solísa,
, Lusmey Fernández Antuñab, Yolanda Royo Cuadrac, Ester Castellarnau Figuerasd
Corresponding author
a Servicio de Pediatría, Hospital Universitario Joan XXIII, Tarragona, Spain
b Gastroenterología Pediátrica, Servicio de Pediatría, Hospital Universitario Joan XXIII, Tarragona, Spain
c Servicio de Cirugía Pediátrica, Hospital Universitario Joan XXIII, Tarragona, Spain
d Urgencias de Pediatría, Servicio de Pediatría, Hospital Universitario Joan XXIII, Tarragona, Spain
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"correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad perianal como primera manifestación en la enfermedad de Crohn pediátrica" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Paediatric Crohn's disease (CD) has a higher incidence of complications than Crohn's disease in adults. Perianal disease (PAD) is also a predictive factor of poor prognosis, justifying a more aggressive treatment.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Three cases of paediatric patients diagnosed with CD and PAD with a single manifestation at onset are reported, with the objective of describing their presentation, phenotypic findings and outcome.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Case 1: 12-year-old male with iron-deficiency anaemia. Presenting with deep anal fissure and associated rectal bleeding of 3 months’ evolution, with no improvement with topical treatments. Mother was affected by CD, associated with weight loss in recent months. Diarrhoea and fever were presented in the last week. The examination revealed perianal area with mucosal folds, two anal fissures, one with fistulous tracts and suppuration. Laboratory test results: iron deficiency anaemia, CRP 4.3<span class="elsevierStyleHsp" style=""></span>mg/dl, albumin normal, faecal calprotectin: 82<span class="elsevierStyleHsp" style=""></span>μg/g, infection screening negative. Upper gastrointestinal (GI) endoscopy: normal and ileocolonoscopy (IC) with biopsies of multiple segments, compatible with ileocolonic CD (A1b,L3,P,G-0 Paris classification). The pelvic MRI scan revealed a simple fistula and an abscess in the perianal region. wPCDAI: 60. Induction was started with adalimumab at a dose of 160, 80 and 40<span class="elsevierStyleHsp" style=""></span>mg/every 14 days of maintenance, and azathioprine and antibiotic therapy with metronidazole for 3 weeks, along with progressive clinical improvement. Patient readmitted after 1 month with erythema nodosum and fever without focal point and kidney failure during admission, suspending the azathioprine with resolution of the symptoms. Patient is currently undergoing treatment with adalimumab in monotherapy with good control.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Case 2: 8-year-old male attended for haematochezia associated with anal fissure with normal bowel movements of two years’ evolution. Since then stagnant weight-to-height ratio. On physical examination: deep anal fissure and sentinel polyp in anal margin. Laboratory tests revealed iron deficiency and hypogammaglobulinaemia, infection screening negative, faecal calprotectin 2758<span class="elsevierStyleHsp" style=""></span>μg/g. Upper GI endoscopy and IC with normal macroscopic appearance, the staggered biopsies confirming the presence of non-necrotising granulomatous inflammation suggesting the diagnosis of intestinal bowel disease (A1a,L3,P,G-1 Paris classification). An MRI scan was performed: fistulas and abscesses were ruled out. Bone mineral density (BMD) was determined, presenting a <span class="elsevierStyleItalic">Z</span>-score of −2.5 in total body. wPCDAI: 25. Treatment was started with infliximab at a 5<span class="elsevierStyleHsp" style=""></span>mg/kg/day/every 8 weeks and azathioprine up to 2.5<span class="elsevierStyleHsp" style=""></span>mg/kg/day. At 7 months, the patient presented perianal abscess that required surgical draining and antibiotic therapy for 21 days. The patient developed anti-infliximab antibodies with undetectable levels of the drug. It was therefore decided to change treatment to adalimumab 40<span class="elsevierStyleHsp" style=""></span>mg/every 14 days. Subsequently, scarring of the abscess and currently on intensified adalimumab every 7 days with good progress.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Case 3: 11-year-old male. Referred from paediatric surgical consultation for recurrent anal abscesses of 3 years’ evolution that had required surgical drainage. Patient is currently asymptomatic and with no perianal lesions. Laboratory tests revealed iron deficiency, ESR and CRP and infection screening negative. Faecal calprotectin: 1144<span class="elsevierStyleHsp" style=""></span>μg/g. Upper GI endoscopy and IC that revealed endoscopic lesions compatible with ileocolonic CD (A1b,L3,B1,G-0 Paris classification). Study completed with pelvic MRI which revealed left perianal fibrous tract, with no signs of acute activity. BMD was normal. Exclusive enteral nutrition (EEN) and maintenance treatment with azathioprine at 2<span class="elsevierStyleHsp" style=""></span>mg/kg/day were initiated. Induction was completed at 8 weeks with EEN. At 1 year of treatment, monotherapy with azathioprine was maintained at 2.5<span class="elsevierStyleHsp" style=""></span>mg/kg/day and with no new perianal lesions.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Perianal involvement is inflammation close to the anus and includes polyps, fissures, abscesses and/or stenosis.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Information is limited in the paediatric population with an incidence of PAD of between 13.6% and 62% and at diagnosis of CD, 15% had perianal lesions. Young age and severe intestinal involvement have been associated with its onset.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The clinical symptoms are diverse and the patient may even be asymptomatic. PAD may be the only manifestation of the CD and precede the intestinal symptomatology even by years.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Fistulising symptoms have been associated with a worse prognosis.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The objective of the treatment is to achieve the healing of the abscesses and total closure of the fistula. The arrival of anti-TNF drugs has meant a change in the treatment of these patients, biological therapy being recommended in induction and maintenance of the fistulising paediatric PAD, combined with surgery if necessary. Antibiotics are appropriate to support closure of the fistula.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In cases without fistulising involvement, it is not clear whether it would be advisable to start early biological therapy, but due to its association with fistulising disease it could be beneficial.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In children with recurrent perianal disease, CD should be ruled out as it is often the only manifestation. This would help the provision of early treatment and prevent complications.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Sosa Solís AM, Fernández Antuña L, Royo Cuadra Y, Castellarnau Figueras E. Enfermedad perianal como primera manifestación en la enfermedad de Crohn pediátrica. Gastroenterol Hepatol. 2020;43:256–257.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The characteristics and long-term outcomes of pediatric Crohn's disease patients with perianal disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Y. 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Moreno" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "editores" => "C.Sánchez, G.Álvarez, M.Tolín" "titulo" => "Manual práctico de enfermedad inflamatoria intestinal pediátrica" "paginaInicial" => "213" "paginaFinal" => "228" "serieFecha" => "2015" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Course and treatment of perianal disease in children newly diagnosed with Crohn's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.J. Keljo" 1 => "J. Markowitz" 2 => "C. Langton" 3 => "T. Lerer" 4 => "A. Bousvaros" 5 => "R. Carvalho" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ibd.20767" "Revista" => array:6 [ "tituloSerie" => "Inflamm Bowel Dis" "fecha" => "2009" "volumen" => "15" "paginaInicial" => "383" "paginaFinal" => "387" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19023863" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F.M. Ruemmele" 1 => "G. Veres" 2 => "K.L. Kolho" 3 => "A. Griffiths" 4 => "A. Levine" 5 => "J.C. Escher" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.crohns.2014.04.005" "Revista" => array:6 [ "tituloSerie" => "J Crohns Colitis" "fecha" => "2014" "volumen" => "8" "paginaInicial" => "1179" "paginaFinal" => "1207" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24909831" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack515668" "titulo" => "Acknowledgement" "texto" => "<p id="par0055" class="elsevierStylePara elsevierViewall">The institution that has provided us with the patients’ medical records is Hospital Universitario Joan XXIII, Tarragona, Spain.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/24443824/0000004300000005/v2_202102251017/S2444382420300766/v2_202102251017/en/main.assets" "Apartado" => array:4 [ "identificador" => "77930" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Scientific letter" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/24443824/0000004300000005/v2_202102251017/S2444382420300766/v2_202102251017/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444382420300766?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 3 | 9 |
| 2024 October | 42 | 2 | 44 |
| 2024 September | 51 | 5 | 56 |
| 2024 August | 53 | 5 | 58 |
| 2024 July | 48 | 5 | 53 |
| 2024 June | 36 | 5 | 41 |
| 2024 May | 54 | 4 | 58 |
| 2024 April | 51 | 5 | 56 |
| 2024 March | 33 | 3 | 36 |
| 2024 February | 59 | 5 | 64 |
| 2024 January | 52 | 5 | 57 |
| 2023 December | 61 | 4 | 65 |
| 2023 November | 62 | 13 | 75 |
| 2023 October | 76 | 5 | 81 |
| 2023 September | 60 | 3 | 63 |
| 2023 August | 41 | 1 | 42 |
| 2023 July | 39 | 4 | 43 |
| 2023 June | 38 | 6 | 44 |
| 2023 May | 51 | 1 | 52 |
| 2023 April | 50 | 1 | 51 |
| 2023 March | 47 | 6 | 53 |
| 2023 February | 24 | 2 | 26 |
| 2023 January | 29 | 10 | 39 |
| 2022 December | 13 | 3 | 16 |
| 2022 November | 21 | 8 | 29 |
| 2022 October | 15 | 12 | 27 |
| 2022 September | 9 | 9 | 18 |
| 2022 August | 21 | 16 | 37 |
| 2022 July | 9 | 7 | 16 |
| 2022 June | 16 | 5 | 21 |
| 2022 May | 26 | 19 | 45 |
| 2022 April | 1 | 0 | 1 |
| 2022 March | 1 | 0 | 1 |
| 2021 June | 1 | 2 | 3 |
| 2021 March | 1 | 0 | 1 |
| 2021 February | 0 | 1 | 1 |
| 2021 January | 0 | 2 | 2 |
| 2020 October | 0 | 1 | 1 |
| 2020 September | 3 | 0 | 3 |
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