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Rare cause of acute abdomen: Small bowel metastasis from lung cancer
Causa rara de abdomen agudo: metátasis intestinales de cáncer de pulmón
Maria Dolores Picardo Gomendioa,
Corresponding author
lolapicardo2@gmail.com

Corresponding author.
, Alba Manuel Vázqueza, Cristina Garcia Amadora, Yuri Rodrigues Figueirab, Antonio Candiab, Roberto de la Plaza Llamasa, José Manuel Ramia Ángelc
a Servicio de Cirugía y del Aparato Digestivo, Hospital General Universitario de Guadalajara, Guadalajara, Spain
b Servicio de Anatomía Patológica, Hospital General Universitario de Guadalajara, Guadalajara, Spain
c Hospital General Universitario de Alicante; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Lung cancer small bowel metastases are rare&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Their diagnosis is difficult&#44; as most of them are asymptomatic&#44; although they can sometimes cause symptoms related to complications&#46; In the presence of abdominal symptoms in patients with lung cancer&#44; we should suspect a lung cancer small bowel metastasis&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We describe 2 cases of patients with acute abdomen secondary to lung cancer small bowel metastasis&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case 1</span><p id="par0015" class="elsevierStylePara elsevierViewall">58-year-old male&#44; smoker&#44; who presented in the Emergency Room for a seizure&#46; Bilateral supratentorial masses consistent with brain metastases were observed on the brain computed tomography &#40;CT&#41;&#46; The chest-abdomen-pelvis CT revealed a pulmonary nodule in the left upper lobe infiltrating the pleura&#44; with mediastinal and intra-abdominal lymphadenopathy&#46; On&#176; day 7&#44; a CT scan was performed for abdominal pain&#44; which revealed pneumoperitoneum&#44; distension of the small bowel loops and free fluid &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; Urgent surgery was performed&#44; in which a perforated jejunal tumour and generalised peritonitis were observed&#46; Segmental resection and anastomosis were performed&#46; Subsequently&#44; CT-guided chest puncture histology revealed a lung adenocarcinoma&#46; The patient was discharged 8 days later without complications &#40;Clavien 0&#44; CCI&#58; 0&#41;&#46; The histological study of the small intestine showed a poorly differentiated adenocarcinoma consistent with pulmonary origin &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B and C&#41;&#46; The patient died 2 months after surgery due to tumour progression &#40;Clavien V&#44; CCI&#58; 100&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Case 2</span><p id="par0020" class="elsevierStylePara elsevierViewall">A 46-year-old woman&#44; on immunotherapy with nivolumab for undifferentiated stage IV carcinoma of unknown origin&#44; stable for one year&#46; She was hospitalised for general malaise and vomiting&#46; Intestinal obstruction secondary to jejunal invagination was observed on the abdominal CT &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>E&#8211;G&#41;&#46; The surgery confirmed invagination&#44; with a palpable and indurated lesion inside&#44; with no further findings&#59; segmental resection and anastomosis were performed&#46; The histological result was infiltration due to lung adenocarcinoma &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>H and I&#41;&#46; The patient presented with deep vein thrombosis and acute respiratory failure secondary to pleural effusion &#40;Clavien IIIb&#44; CCI&#58; 33&#46;5&#41;&#46; She was readmitted one month later for pleural effusion&#46; She received palliative treatment and subsequently died &#40;Clavien V&#44; CCI&#58; 100&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Approximately 50&#37; of lung cancer patients have metastases at diagnosis<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and the incidence of locoregional or distant recurrence after treatment is 50&#37; at 2 years&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Lung cancer can spread lymphatically or haematogenously&#59; the liver&#44; brain&#44; adrenal gland and bone are the most common locations&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;5</span></a> although dissemination patterns vary according to histological type&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Metastatic involvement in other locations is rare &#40;less than 5&#37;&#41;&#44; is more frequent in men and usually presents with multiple lesions&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> It usually appears in terminal patients with disseminated disease in several locations&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a> Of these lesions&#44; gastrointestinal lesions have an incidence of 0&#46;3&#37;&#8211;1&#46;7&#37;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#44; and are located&#44; in order of frequency&#44; in the oesophagus&#44; small intestine&#44; stomach and colon&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a> In the small intestine&#44; they predominantly affect the jejunum-ileum&#44; as in our patients&#44; and to a lesser extent the duodenum&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The clinical manifestations of lung cancer small bowel metastases are usually rare or confused with the gastrointestinal effects of chemotherapy&#46; In fact&#44; in <span class="elsevierStyleItalic">post mortem</span> studies&#44; their incidence increases to 4&#46;6&#37;&#8211;14&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In rare cases&#44; the first clinical manifestation of lung cancer is due to gastrointestinal metastatic involvement&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Symptomatic intestinal metastases due to complications such as upper gastrointestinal bleeding&#44; perforation or obstruction have been described&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a> Therefore&#44; in patients with acute abdomen and lung cancer&#44; they should be considered in the differential diagnoses&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The most appropriate treatment for intestinal metastases is under debate and is influenced by the clinical picture&#46; In the case of complications&#44; as in our patients&#44; the recommended treatment is surgery&#44; with segmental intestinal resection and anastomosis&#46; In the case of invagination&#44; previous disinvagination should be avoided due to the risk of neoplastic spread&#44; perforation and complications in the anastomosis caused by manipulation&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Gastrointestinal metastases in lung cancer worsen the prognosis and reduce survival&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The presence of intestinal perforation&#44; other extraintestinal metachronous metastases and age are factors that tend to indicate a poorer prognosis&#46; In these cases&#44; survival is usually a question of weeks or months&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Lung cancer small bowel metastases are rare and mostly asymptomatic&#46; Therefore&#44; a high degree of suspicion is required to make the right diagnosis&#46; Their appearance is associated with a worse prognosis and lower survival&#46;</p></span></span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">A</span>&#41; Case 1 abdominal CT axial slice&#58; pneumoperitoneum &#40;arrow&#41;&#46; <span class="elsevierStyleBold">B</span>&#41; Case 1 histology&#58; wall of the small intestine infiltrated by the tumour&#46; Infiltration from the peritoneal layer towards the mucosa&#44; in which small tumour nests&#44; ulceration and surface necrosis are observed&#46; <span class="elsevierStyleBold">C</span>&#41; Case 1 immunohistochemistry&#46; Positivity for cytokeratin 7 in the membrane and cytoplasm in the tumour&#46; <span class="elsevierStyleBold">D</span>&#41; Case 1 immunohistochemistry&#46; Positive TTF-1 in the infiltrating tumour&#46; <span class="elsevierStyleBold">E&#8211;G&#41;</span> Case 2 abdominal CT&#58; small intestine invagination &#40;arrow&#41;&#46; <span class="elsevierStyleBold">H&#41;</span> Case 2 histology&#58; panoramic view of the ulcerated intestinal wall infiltrated by adenocarcinoma throughout its thickness&#46; <span class="elsevierStyleBold">I</span>&#41; Case 2 histology&#58; sheet-like growth of the neoplasm&#44; forming solid nests&#44; cells with the presence of intracytoplasmic vacuoles and cell lumina&#46;</p>"
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