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Inicio Hipertensión y Riesgo Vascular ¿Existe respuesta diferente a los distintos inhibidores de PCSK9?
Journal Information
Vol. 37. Issue 1.
Pages 42-44 (January - March 2020)
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Vol. 37. Issue 1.
Pages 42-44 (January - March 2020)
Caso clínico
¿Existe respuesta diferente a los distintos inhibidores de PCSK9?
Are there different responses to different PCSK9 inhibitors?
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261
Á. Asenjo Motaa,
Corresponding author
angel.asenjo@hospitalreyjuancarlos.es

Autor para correspondencia.
, O. Caamaño Selmaa, R. Sánchez-Aquino Gonzálezb
a Medicina Interna, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid, España
b Cardiología, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid, España
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Resumen

Planteamos un paciente de 62 años que precisa tratamiento hipolipemiante con inhibidor de la proproteína convertasa subtilisina/kexina tipo9 (PCSK9) en el que empíricamente decidimos cambiar un fármaco a otro de los dos disponibles en la actualidad, obteniendo diferente respuesta. Nuestro objetivo es transmitir nuestra experiencia y reflexionar sobre una posible opción terapéutica en los pacientes en los que excepcionalmente esto pudiera ocurrir.

Palabras clave:
Hipercolesterolemia
Alirocumab
Evolocumab
Anticuerpos antifármaco
Abstract

The case is presented of a 62-year-old patient who required lipid-lowering therapy with proprotein convertase subtilisin/kexin type9 (PCSK9). It was empirically decided to change one drug to another of the two currently available, obtaining a different response. Our objective is to present our experience and to consider a possible therapeutic option in patients in whom, exceptionally, this could happen.

Keywords:
Hypercholesterolaemia
Alirocumab
Evolocumab
Anti-drug antibodies

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