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Vol. 15. Issue 4.
Pages 268-276 (December 2011)
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Vol. 15. Issue 4.
Pages 268-276 (December 2011)
Open Access
Prevalencia del virus papiloma humano y sus factores de riesgo en hombres: revisión sistemática
Prevalence of human papillomavirus virus and risk factors in men: a systematic review
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Jaiberth Cardona-Arias1,
Corresponding author
jaiberthcardona@gmail.com

Correspondencia: Jaiberth Cardona Arias. Escuela de Microbiología, Universidad de Antioquia, Calle 67 N° 53-108, Bloque 5, oficina 103, Medellín, Colombia. Teléfonos: 219-8486 y (312) 250-7090; fax: 219-5486.
, Jenniffer Puerta-Suárez2, Jenniffer Flórez-Duque2
1 Grupo de investigación Salud y Sostenibilidad, Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia
2 Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia
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Resumen
Introducción

El virus del papiloma humano (Human Papilloma Virus, HPV) es el causante de diversos cánceres del sistema genitourinario; se ha detectado en 97,4 % de los casos de cáncer de cuello uterino. No obstante su alta prevalencia, ha sido poco estudiado en hombres y las investigaciones realizadas presentan resultados divergentes.

Objetivo

Describir el comportamiento de la infección por HPV en hombres y sus factores de riesgo, a partir de la combinación de diversos estudios.

Materiales y métodos

Se trata de una revisión sistemática de la literatura científica con base en estudios publicados en español, inglés y portugués, en 10 bases de datos multidisciplinarias. Se incluyeron investigaciones realizadas en diferentes poblaciones, a partir de la implementación de un protocolo de búsqueda que incluyó criterios de inclusión y exclusión, aplicados por tres investigadores de forma independiente.

Resultados

Se incluyeron 17 artículos, los cuales correspondían a una población de 8.788 hombres universitarios o militares, con VIH u otra infección de transmisión sexual, y compañeros de mujeres con cáncer de cuello uterino o que estaban infectadas con HPV. La prevalencia global de la infección fue de 38 %, con un rango entre 9 y 84 %. Los principales factores de riesgo de la infección incluyeron aspectos sociodemográficos, clínicos y de comportamiento.

Conclusión

La disminución de la prevalencia de infección por HPV depende de la implementación de estrategias de intervención que incluyan hombres y cuyo eje sean los factores de riesgo y no los grupos de riesgo.

Palabras clave:
HPV
frecuencia
prevalencia
epidemiología
factor de riesgo
hombres
Abstract
Introduction

Human Papilloma Virus (HPV) is responsible for various cancers of the genitourinary tract, it has been detected in 97.4% of cases of cervical cancer, despite its high prevalence, it has not been studied in men and investigations inform divergent results.

Objective

To describe the prevalence of HPV infection in men and their risk factors, from the combination of several studies.

Materials and methods

Systematic review of the literature based on studies published in English, Spanish and Portuguese in 10 multidisciplinary databases. Research included different populations, using a search protocol that included inclusion and exclusion criteria applied independently by three researchers.

Results

We included 17 papers which correspond to a population of 8788 men, college students, military members, HIV infected or with other sexually transmitted infection and partners of women with cervical cancer or infected with HPV. The general prevalence of infection was 38%, ranging between 9% and 84%. The main risk factors for infection included sociodemographic, clinical and behavioral aspects.

Conclusion

The decreasing prevalence of HPV infection depends on the implementation of intervention strategies that include men and with axis in risk factors and not in risk groups.

Keywords:
HPV
frequency
prevalence
epidemiology
risk factor
men
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Referencias
[1.]
X. Wanga, J. Zhuang, K. Wu, K. Xub, M. Licd, Y. Lua.
Human semen: The biological basis of sexual behaviour to promote human papillomavirus infection and cervical cancer.
Med Hypotheses., 74 (2010), pp. 1015-1016
[2.]
F.X. Bosch, M.M. Manos, N. Muñoz, M. Sherman, A.M. Jansen, J. Peto, et al.
Prevalence of human papillomavirus in cervical cancer: A worldwide perspective.
J Natl Cancer Inst., 87 (1995), pp. 796-802
[3.]
World Health Organization.
Vacunas contra el virus del papiloma humano documento de posición de la OMS.
Weekly Epidemiological Record., 84 (2009), pp. 117-132
[4.]
World Health Organization.
Assessment and harmonization of laboratory diagnostic procedures related to human papillomavirus vaccine research and development.
Report of a technical meeting Heidelberg, (2001),
[5.]
Organización Panamericana de la Salud. Investigadores informan que mejoras en detección y tratamiento, junto con vacunas más asequibles, pueden evitar que las muertes por cáncer de cuello uterino se multipliquen por dos en Latinoamérica y el Caribe. México; 2008. Fecha de consulta: 14 de febrero de 2011. Disponible en: http://www.paho.org/spanish/dd/pin/ps080512.htm.
[6.]
S. Vaccarella, E. Lazcano-Ponce, J.A. Castro-Garduno, A. Cruz-Valdez, V. Díaz, R. Schiavon, et al.
Prevalence and determinants of human papillomavirus infection in men attending vasectomy clinics in Mexico.
Int J Cancer., 119 (2006), pp. 1934-1939
[7.]
X. Castellsagué, X. Bosch, N. Muñoz.
The male role in cervical cancer.
Salud Pública Mex., 45 (2003), pp. 345-353
[8.]
A.R. Giuliano, B. Lu, C.M. Nielson, R. Flores, M.R. Papenfuss, J.H. Lee, et al.
Age-specific prevalence, incidence, and duration of human papillomavirus infections in a cohort of 290 US men.
J Infect Dis., 198 (2008), pp. 827-835
[9.]
M. Sánchez, F. Uribe, C. Conde.
La infección por el virus del papiloma humano, un posible marcador biológico de comportamiento sexual en estudiantes universitarios.
Salud Pública Mex., 44 (2002), pp. 442-447
[10.]
L.V. Aguilar, E. Lezcano, S. Vacarella, A. Cruz, P. Hernández, J.S. Smith, et al.
Human papillomavirus in men: Comparison of different genital sites.
Sex Transm Infect., 82 (2006), pp. 31-33
[11.]
E. Lezcano, R. Herrero, N. Muñoz, M. Hernández, J. Salmerón, A. Leyva, et al.
High prevalence of human papillomavirus infection in Mexican males.
SexTransm Dis., 28 (2001), pp. 277-280
[12.]
P. Guzmán, C. Lli, P. Rifo, G. Briceño, J. Araya, M. Villaseca, et al.
Prevalencia de la infección genital por virus papiloma humano en hombres universitarios voluntarios de la IX región.
Chile. Rev Med Chile., 136 (2006), pp. 1381-1389
[13.]
S.M. Nicolau, C.G. Camargo, J.N. Stavale, A. Castelo, G.B. Dores, A. Lorincz, et al.
Human papillomavirus DNA detection in male sexual partners of women with genital human papillomavirus infection.
Urology., 65 (2005), pp. 251-255
[14.]
B. Auvert, J. Sobngwi-Tambekou, E. Cutler, M. Nieuwoudt, P. Lissouba, A. Puren, et al.
Effect of male circumcision on the prevalence of high-risk human papillomavirus in young men: Results of a randomized controlled trial conducted in Orange Farm.
South Africa. J Infect Dis., 199 (2009), pp. 14-19
[15.]
S.B. Baldwin, D.R. Wallace, M.R. Papenfuss, M. Abrahamsen, L.C. Vaught, J.R. Kornegay, et al.
Human papillomavirus infection in men attending a sexually transmitted disease clinic.
J Infect Dis., 187 (2003), pp. 1064-1070
[16.]
S.B. Baldwin, D.R. Wallace, M.R. Papenfuss, M. Abrahamsen, L.C. Vaught, A.R. Giuliano.
Condom use and other factors affecting penile human papillomavirus detection in men attending a sexually transmitted disease clinic.
Sex Transm Dis., 31 (2004), pp. 601-607
[17.]
M.C. Bleeker, J. Berkhof, C.J. Hogewoning, F.J. Voorhorst, A.J. van den Brule, T.M. Starink, et al.
HPV type concordance in sexual couples determines the effect of condoms on regression of flat penile lesions.
Br J Cancer., 92 (2005), pp. 1388-1392
[18.]
X. Castellsagué, F.X. Bosch, N. Muñoz, C.J. Meijer, K.V. Shah, S. de Sanjose, International Agency for Research on Cancer Multicenter Cervical Cancer Study Group, et al.
Male circumcision, penile human papillomavirus infection, and cervical cancer in female partners.
N Engl J Med., 346 (2002), pp. 1105-1112
[19.]
A.R. Giuliano, E. Lazcano, L.L. Villa, R. Flores, J. Salmeron, J.H. Lee, et al.
Circumcision and sexual behavior: Factors independently associated with human papillomavirus detection among men in the HIM study.
Int J Cancer., 124 (2009), pp. 1251-1257
[20.]
B.Y. Hernandez, L.R. Wilkens, X. Zhu, K. McDuffie, P. Thompson, Y.B. Shvetsov, et al.
Circumcision and human papillomavirus infection in men: A site-specific comparison.
J Infect Dis., 197 (2008), pp. 787-794
[21.]
S.K. Kjaer, C. Munk, J.F. Winther, H.O. Jorgensen, C.J. Meijer, A.J. van den Brule.
Acquisition and persistence of human papillomavirus infection in younger men: A prospective follow-up study among Danish soldiers.
Cancer Epidemiol Biomarkers Prev., 14 (2005), pp. 1528-1533
[22.]
M. Lajous, N. Mueller, A. Cruz-Valdez, L.V. Aguilar, S. Franceschi, M. Hernandez- Avila, et al.
Determinants of prevalence, acquisition, and persistence of human papillomavirus in healthy Mexican military men.
Cancer Epidemiol Biomarkers Prev., 14 (2005), pp. 1710-1716
[23.]
C.M. Nielson, R. Flores, R.B. Harris, M. Abrahamsen, M.R. Papenfuss, E.F. Dunne, et al.
Human papillomavirus prevalence and type distribution in male anogenital sites and semen.
Cancer Epidemiol Biomarkers Prev., 16 (2007), pp. 1107-1114
[24.]
A. Nyitray, C.M. Nielson, R.B. Harris, R. Flores, M. Abrahamsen, E.F. Dunne, et al.
Prevalence of and risk factors for anal human papillomavirus infection in heterosexual men.
J Infect Dis., 197 (2008), pp. 1676-1684
[25.]
G.S. Ogilvie, D.L. Taylor, M. Achen, D. Cook, M. Krajden.
Self-collection of genital human papillomavirus specimens in heterosexual men.
Sex Transm Infect., 85 (2009), pp. 221-225
[26.]
E.I. Svare, S.K. Kjaer, A.M. Worm, A. Osterlind, C.J. Meijer, A.J. van den Brule.
Risk factors for genital HPV DNA in men resemble those found in women: A study of male attendees at a Danish STD clinic.
Sex Transm Infect., 78 (2002), pp. 215-218
[27.]
X. Tang, A.E. Xu, X.P. Dong, X.K. Sun, H. Shen, J.F. Liu.
Epidemiological investigation of human papillomavirus infection in men attending a sexually transmitted disease clinic in Hangzhou area.
Biomed Environ Sci., 19 (2006), pp. 153-157
[28.]
S. Vaccarella, E. Lazcano-Ponce, J.A. Castro-Garduno, A. Cruz-Valdez, V. Diaz, R. Schiavon, et al.
Prevalence and determinants of human papillomavirus infection in men attending vasectomy clinics in Mexico.
Int J Cancer., 119 (2006), pp. 1934-1939
[29.]
C.M. Vajdic, M.T. van Leeuwen, F. Jin, G. Prestage, G. Medley, R.J. Hillman, et al.
Anal human papillomavirus genotype diversity and co-infection in a community-based simple of homosexual men.
Sex Transm Infect., 85 (2009), pp. 330-335
[30.]
E. Dunne, C. Nielson, K. Stone, L. Markowitz, A. Giuliano.
Prevalence of HPV Infection among men: A systematic review of the literature.
J Infect Dis., 194 (2006), pp. 1044-1057
[31.]
A. Gonçalves Ayres, S. Gulnar Azevedo.
Prevalência de infecção do colo do útero pelo HPV no Brasil: revisão sistemática.
Rev Saúde Pública., 44 (2010), pp. 963-974
[32.]
N.V. Revzina, R.J. Diclemente.
Prevalence and incidence of human papillomavirus infection in women in the USA: A systematic review.
Int J STD AIDS., 16 (2005), pp. 528-537
[33.]
P. Chin-Hong, M. Husnik, R. Cranston, G. Colfaz, S. Buchbinder, M. Costa.
Anal human papillomavirus infection is associated with HIV acquisition in men who have sex with men.
[34.]
S. Goldstone, J.M. Palefsky, A.R. Giuliano, E.D. Moreira Jr., C. Aranda, H. Jessen, et al.
Prevalence of and risk factors for human papillomavirus (HPV) infection among HIV-seronegative men who have sex with men.
J Infect Dis., 203 (2011), pp. 66-74
[35.]
M. Benevolo, M. Mottolese, F. Marandino, M. Carosi, M.G. Diodoro, S. Sentinelli, et al.
HPV prevalence among healthy Italian male sexual partners of women with cervical HPV infection.
J Med Virol., 80 (2008), pp. 1275-1281
[36.]
F. Venezuela, L.E. Kremer, X. Kiguen, C. Cuffini.
HPV detection and genotyping in males from the city of Córdoba.
Argentina. Rev Argent Microbiol., 42 (2010), pp. 184-188
[37.]
M. Heiligenberg, K.M. Michael, M.A. Kramer, M. Pawlita, M. Prins, R.A. Coutinho, et al.
Seroprevalence and determinants of eight high-risk human papillomavirus types in homosexual men, heterosexual men, and women: A population-based study in Amsterdam.
Sex Transm Dis., 37 (2010), pp. 672-680
[38.]
J.M. Palefsky, E.A. Holly, M.L. Ralston, N. Jay.
Prevalence and risk factors for human papillomavirus infection of the anal canal in human immunodeficiency virus (HIV) positive and HIV negative homosexual men.
J Infect Dis., 177 (1998), pp. 361-367
[39.]
P.A. Gilbert, N.T. Brewer, P.L. Reiter.
Association of human papillomavirus- related knowledge, attitudes, and beliefs with HIV status: A national study of gay men.
J Low Genit Tract Dis., 15 (2011), pp. 83-88
[40.]
J.R. Daling, M.M. Madeleine, L.G. Johnson, S.M. Schwartz, K.A. Shera, M.A. Wurscher, et al.
Penile cancer: Importance of circumcision, human papillomavirus and smoking in in situ and invasive disease.
Int J Cancer., 116 (2005), pp. 606-616
Copyright © 2011. Asociación Colombiana de Infectología (ACIN)
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