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Inicio Medicina Clínica Cancer associated autoantibodies in idiopathic inflammatory myopathies: A retros...
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Vol. 160. Issue 1.
Pages 10-16 (January 2023)
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Vol. 160. Issue 1.
Pages 10-16 (January 2023)
Original article
Cancer associated autoantibodies in idiopathic inflammatory myopathies: A retrospective cohort from a single center in China
Autoanticuerpos relacionados con el cáncer en miopatía inflamatoria idiopática: estudio retrospectivo de cohortes de un solo centro en China
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Yin Zhao, Haiyuan Su, Xiaoyang Yin, Hou Hou, Ying’ai Wang, Yong Xu, Xin Li, Nang Zhang, Wenwen Sun, Wei Wei
Corresponding author
tjweiwei2003@163.com

Corresponding author.
Department of Rheumatology and Immunology, Tianjin Medical University General Hospital, Tianjin 300020, China
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Abstract
Objectives

Idiopathic inflammatory myopathies (IIMs) are systemic, heterogeneous diseases, which mainly affect skeletal muscle. Myositis with cancer is often referred to as cancer-associated myositis (CAM), which is associated with poor prognosis. This study aimed to determine the cancer associated myositis-specific autoantibodies (MSAs) and to elucidate their associations with clinical features in Chinese patients with IIMs.

Methods

This retrospective study enrolled 312 patients with IIMs who were treated at Tianjin Medical University General Hospital, China, from January 2015 to December 2020. Clinical data were collected. Serum MSAs, including anti-Mi-2, anti-TIF1-γ, anti-NXP2, anti-SAE, anti-MDA5, anti-SRP, anti-Jo-1, anti-PL-7, anti-PL-12, anti-OJ, anti-EJ and anti-HMGCR antibodies were detected. Cancer-associated MSAs, their phenotypic and survival features were estimated through SPSS 20.0.

Results

The results revealed that anti-TIF1-γ antibody and anti-SAE antibody were cancer-associated autoantibodies with odds ratios (95% CI) of 8.70 (3.35–22.64) and 22.31 (4.32–115.05), respectively. Skin lesions, proximal weakness, dysphagia and dysarthria were observed more frequently in patients carrying anti-TIF1-γ antibody. By contrast, patients with anti-TIF1-γ antibody had a lower frequencies of fever, arthritis/arthralgia and interstitial lung disease (ILD). Anti-TIF1-γ antibody positive CAM comprised about half of CAM entities and had the characteristic of close temporal association with cancer detection/recurrence. Female-dominant, common reproductive system tumors were other clinical features of this subset. Besides, patients with anti-TIF1-γ antibody positive had significantly lower survival rates than the anti-TIF1-γ antibody negative group.

Conclusions

Anti-TIF1-γ antibody and anti-SAE antibody were cancer-associated autoantibodies. Anti-TIF1-γ antibody positive CAM was a subset that comprised about half of CAM entities and had the characteristic of poor prognosis.

Keywords:
Anti-TIF1-γ antibody
Idiopathic inflammatory myopathy
Cancer
Prognosis
Resumen
Objetivo

La miopatía inflamatoria idiopática (IIM, por sus siglas en inglés) es una enfermedad sistémica y heterogénea que afecta principalmente al músculo esquelético. La miositis asociada al cáncer se denomina a menudo miositis relacionada con el cáncer, y está relacionada con un mal pronóstico. El objetivo de este estudio fue identificar autoanticuerpos específicos de miositis relacionados con el cáncer en pacientes chinos, y dilucidar su correlación con las características clínicas.

Métodos

El estudio retrospectivo incluyó a 312 pacientes con IIM tratados en el hospital general de la Universidad Médica de Tianjin, China, de enero de 2015 a diciembre de 2020. Recoger datos clínicos. Se detectaron autoanticuerpos específicos de miositis sérica, incluyendo anti-Mi-2, anti-TIF1-γ, anti-NXP2, anti-SAE, anti-MDA5, anti-SRP, anti-Jo-1, anti-PL-7, anti-PL-12, anti-OJ, anti-EJ, anti-HMGCR. Los autoanticuerpos relacionados con el cáncer, sus fenotipos y sus características de supervivencia fueron evaluados por SPSS® 20.0.

Resultados

Los resultados mostraron que el anticuerpo anti-TIF1-γ y el anticuerpo anti-SAE eran autoanticuerpos relacionados con el cáncer con una relación de predominio (IC 95%) de 8,70 (3,35–22,64) y 22,31 (4,32–115,05), respectivamente. La frecuencia de lesiones cutáneas, debilidad proximal, disfagia y disartria fue mayor en los pacientes portadores de anticuerpos anti-TIF1-γ. En comparación, la incidencia de fiebre, artritis/artralgia y enfermedad pulmonar intersticial (ILD) en pacientes con anticuerpos anti-TIF1-γ fue menor. La miositis relacionada con el cáncer con anticuerpos anti-TIF1-γ positivos representa aproximadamente la mitad de la miositis relacionada con el cáncer y tiene características temporales estrechamente relacionadas con la detección/recidiva del cáncer. Los tumores del sistema reproductivo que predominan en las mujeres son otras características clínicas de este subgrupo. Además, la tasa de supervivencia de los pacientes con anticuerpos anti-TIF1-γ positivos fue significativamente menor que la del grupo anti-TIF1-γ negativo.

Conclusión

Los anticuerpos anti-TIF1-γ y anti-SAE son autoanticuerpos relacionados con el tumor. Los pacientes con anticuerpos anti-TIF1-γ positivos son un subgrupo, que representa aproximadamente la mitad de los pacientes con miositis relacionada con el cáncer, y tienen un mal pronóstico.

Palabras clave:
Anticuerpo anti-TIF1-γ
Miopatía inflamatoria idiopática
Cáncer
Pronóstico

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