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Journal Information
Vol. 161. Issue 5.
Pages 217-224 (September 2023)
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Vol. 161. Issue 5.
Pages 217-224 (September 2023)
Revisión
Gammapatía monoclonal de significado incierto
Monoclonal gammopathy of uncertain significance
Visits
448
Elena Alejo, Borja Puertas, María-Victoria Mateos
Corresponding author
mvmateos@usal.es

Autor para correspondencia.
Hospital Universitario de Salamanca/Instituto de Investigación Biomédica de Salamanca (IBSAL)/Centro Investigación del Cáncer-IBMCC (USAL-CSIC), Salamanca, España
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Tables (3)
Tabla 1. Criterios diagnósticos y riesgo de progresión de las GMSI (IMWG 2014)
Tabla 2. Índices pronósticos de GMSI
Tabla 3. Recomendaciones en el seguimiento de las GMSI
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Resumen

La gammapatía monoclonal de significado incierto es una neoplasia de células plasmáticas premaligna, con una elevada prevalencia en la población mayor de 50 años, y un riesgo anual de progresión del 1%. Numerosos estudios recientes han permitido un avance en la compresión de la patogenia de estos trastornos y su riesgo de progresión a otras enfermedades. Los pacientes requieren un seguimiento de por vida, siendo fundamental un enfoque multidisciplinar y adaptado al riesgo. En los últimos años, cada vez se reconocen más entidades asociadas a la presencia de una paraproteína, conocidas como gammapatías monoclonales de significado clínico.

Palabras clave:
Gammapatía monoclonal de significado incierto
Screening
Pronóstico
Abstract

Monoclonal gammopathy of uncertain significance is a premalignant plasma cell neoplasm with a high prevalence in the population over 50 years of age and an annual risk of progression of 1%. Multiple recent studies have led to advances in understanding both the pathogenesis of these disorders and their risk of progression to other diseases. Patients require lifelong follow-up, and a multidisciplinary and risk-adapted approach is essential. In recent years, an increasing number of entities associated with a paraprotein, known as clinically significant monoclonal gammopathies, have been recognized.

Keywords:
Monoclonal gammopathy of uncertain significance
Screening
Prognosis

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